HIBADH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The encoded protein plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.77164092
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.77164092
3L-phenylalanine metabolic process (GO:0006558)6.65864945
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.65864945
5aromatic amino acid family catabolic process (GO:0009074)6.14008625
6glyoxylate metabolic process (GO:0046487)5.78898028
7lysine catabolic process (GO:0006554)5.75205594
8lysine metabolic process (GO:0006553)5.75205594
9sulfur amino acid catabolic process (GO:0000098)5.60623545
10cysteine metabolic process (GO:0006534)5.59051023
11tryptophan catabolic process (GO:0006569)5.56714406
12indole-containing compound catabolic process (GO:0042436)5.56714406
13indolalkylamine catabolic process (GO:0046218)5.56714406
14kynurenine metabolic process (GO:0070189)5.43925090
15alpha-linolenic acid metabolic process (GO:0036109)5.28780697
16tryptophan metabolic process (GO:0006568)5.24040095
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.17852484
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.15593306
19bile acid biosynthetic process (GO:0006699)5.06791084
20NADH metabolic process (GO:0006734)4.91914933
21amino-acid betaine metabolic process (GO:0006577)4.90845376
22serine family amino acid catabolic process (GO:0009071)4.90374249
23cellular modified amino acid catabolic process (GO:0042219)4.72356858
24homocysteine metabolic process (GO:0050667)4.69651641
25coenzyme catabolic process (GO:0009109)4.67387085
26urea cycle (GO:0000050)4.61665288
27urea metabolic process (GO:0019627)4.61665288
282-oxoglutarate metabolic process (GO:0006103)4.54735176
29fatty acid beta-oxidation (GO:0006635)4.54669671
30short-chain fatty acid metabolic process (GO:0046459)4.51189921
31aromatic amino acid family metabolic process (GO:0009072)4.49864278
32* alpha-amino acid catabolic process (GO:1901606)4.46875639
33tricarboxylic acid cycle (GO:0006099)4.42377394
34* valine metabolic process (GO:0006573)4.42092009
35complement activation, alternative pathway (GO:0006957)4.40536938
36cellular ketone body metabolic process (GO:0046950)4.35805122
37acetyl-CoA metabolic process (GO:0006084)4.35229983
38* cellular amino acid catabolic process (GO:0009063)4.34927029
39fatty acid oxidation (GO:0019395)4.33025824
40ethanol oxidation (GO:0006069)4.31326310
41regulation of triglyceride catabolic process (GO:0010896)4.29651493
42nitrogen cycle metabolic process (GO:0071941)4.28892675
43aspartate family amino acid catabolic process (GO:0009068)4.26640086
44lipid oxidation (GO:0034440)4.25327993
45bile acid metabolic process (GO:0008206)4.25236148
46protein carboxylation (GO:0018214)4.24469398
47peptidyl-glutamic acid carboxylation (GO:0017187)4.24469398
48negative regulation of fibrinolysis (GO:0051918)4.22453967
49high-density lipoprotein particle remodeling (GO:0034375)4.17210459
50fatty acid catabolic process (GO:0009062)4.16546808
51regulation of protein activation cascade (GO:2000257)4.16074212
52serine family amino acid metabolic process (GO:0009069)4.15365307
53daunorubicin metabolic process (GO:0044597)4.13481741
54polyketide metabolic process (GO:0030638)4.13481741
55doxorubicin metabolic process (GO:0044598)4.13481741
56carnitine metabolic process (GO:0009437)4.11752664
57* branched-chain amino acid catabolic process (GO:0009083)4.11703296
58biotin metabolic process (GO:0006768)4.10253084
59drug transmembrane transport (GO:0006855)4.09882288
60COPI coating of Golgi vesicle (GO:0048205)4.09408797
61Golgi transport vesicle coating (GO:0048200)4.09408797
62tyrosine metabolic process (GO:0006570)4.08602195
63* branched-chain amino acid metabolic process (GO:0009081)4.08559807
64monocarboxylic acid catabolic process (GO:0072329)4.03086907
65* carboxylic acid catabolic process (GO:0046395)4.01862670
66* organic acid catabolic process (GO:0016054)4.01862670
67glycine metabolic process (GO:0006544)4.01088719
68acylglycerol homeostasis (GO:0055090)4.00300779
69triglyceride homeostasis (GO:0070328)4.00300779
70urate metabolic process (GO:0046415)3.98414023
71regulation of fibrinolysis (GO:0051917)3.98138375
72oxaloacetate metabolic process (GO:0006107)3.97708555
73glutamate metabolic process (GO:0006536)3.96546984
74regulation of complement activation (GO:0030449)3.92196356
75indolalkylamine metabolic process (GO:0006586)3.90796435
76drug catabolic process (GO:0042737)3.85919367
77serine family amino acid biosynthetic process (GO:0009070)3.84198473
78aminoglycoside antibiotic metabolic process (GO:0030647)3.82898500
79benzene-containing compound metabolic process (GO:0042537)3.79442216
80cellular biogenic amine catabolic process (GO:0042402)3.78695545
81amine catabolic process (GO:0009310)3.78695545
82plasma lipoprotein particle clearance (GO:0034381)3.77352556
83ketone body metabolic process (GO:1902224)3.76764031
84epoxygenase P450 pathway (GO:0019373)3.73968505
85tricarboxylic acid metabolic process (GO:0072350)3.73393042
86protein-lipid complex remodeling (GO:0034368)3.73390291
87macromolecular complex remodeling (GO:0034367)3.73390291
88plasma lipoprotein particle remodeling (GO:0034369)3.73390291
89dicarboxylic acid biosynthetic process (GO:0043650)3.73272461
90regulation of cholesterol esterification (GO:0010872)3.71503553
91negative regulation of sterol transport (GO:0032372)3.67232770
92negative regulation of cholesterol transport (GO:0032375)3.67232770
93cellular glucuronidation (GO:0052695)3.66731053
94reverse cholesterol transport (GO:0043691)3.66443449
95drug metabolic process (GO:0017144)3.62330065
96fatty acid transmembrane transport (GO:1902001)3.60115989
97ethanol metabolic process (GO:0006067)3.55810022
98cofactor catabolic process (GO:0051187)3.54625808
99positive regulation of fatty acid beta-oxidation (GO:0032000)3.49033336
100flavonoid metabolic process (GO:0009812)3.45419914
101primary alcohol catabolic process (GO:0034310)3.44549496
102bile acid and bile salt transport (GO:0015721)3.42972683
103exogenous drug catabolic process (GO:0042738)3.42726914
104aldehyde catabolic process (GO:0046185)3.41567466
105* small molecule catabolic process (GO:0044282)3.40802302
106drug transport (GO:0015893)3.40654785
107regulation of cholesterol homeostasis (GO:2000188)3.39441768
108regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.39418900
109positive regulation of lipid catabolic process (GO:0050996)3.37431359
110gluconeogenesis (GO:0006094)3.37062059
111phospholipid efflux (GO:0033700)3.36028057
112response to mercury ion (GO:0046689)3.35561781
113regulation of cholesterol metabolic process (GO:0090181)3.34520531
114actin-myosin filament sliding (GO:0033275)3.19956010
115muscle filament sliding (GO:0030049)3.19956010
116omega-hydroxylase P450 pathway (GO:0097267)3.19522312
117hexose biosynthetic process (GO:0019319)3.13576973
118protein retention in ER lumen (GO:0006621)3.13499775
119regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.12673413
120protein maturation by protein folding (GO:0022417)3.11266065
121fibrinolysis (GO:0042730)3.09734861
122maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.05879751
123glycogen catabolic process (GO:0005980)3.04819854
124monosaccharide biosynthetic process (GO:0046364)3.02435625
125positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.01845473
126fructose metabolic process (GO:0006000)2.99209394
127succinate metabolic process (GO:0006105)2.92073247
128proline biosynthetic process (GO:0006561)2.90347824
1294-hydroxyproline metabolic process (GO:0019471)2.89639494
130fatty acid homeostasis (GO:0055089)2.85132952
131creatine metabolic process (GO:0006600)2.81526079
132actin-mediated cell contraction (GO:0070252)2.80555327
133glycoside metabolic process (GO:0016137)2.79475397
134glucan catabolic process (GO:0009251)2.78323387
135regulation of plasminogen activation (GO:0010755)2.78094021
136xenobiotic catabolic process (GO:0042178)2.68611748
137primary alcohol metabolic process (GO:0034308)2.67588579
138galactose catabolic process (GO:0019388)2.62494845
139COPII vesicle coating (GO:0048208)2.62107035
140negative regulation of protein activation cascade (GO:2000258)2.61224737
141glucuronate metabolic process (GO:0019585)2.61050303
142uronic acid metabolic process (GO:0006063)2.61050303
143cellular polysaccharide catabolic process (GO:0044247)2.59422687
144proline metabolic process (GO:0006560)2.58597457
145desmosome organization (GO:0002934)2.58270420
146membrane budding (GO:0006900)2.57723463
147positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.56028906
148proteasome assembly (GO:0043248)2.54299915
149cellular aldehyde metabolic process (GO:0006081)2.53311117
150phenylpropanoid metabolic process (GO:0009698)2.51892126
151AMP metabolic process (GO:0046033)2.50254447
152negative regulation of lipase activity (GO:0060192)2.50210367
153quinone metabolic process (GO:1901661)2.49194037
154retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.45816637
155triglyceride catabolic process (GO:0019433)2.45370000
156dicarboxylic acid metabolic process (GO:0043648)2.43813242
157glucan biosynthetic process (GO:0009250)2.43684530
158glycogen biosynthetic process (GO:0005978)2.43684530

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.52170216
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.17555805
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.57781614
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.77526241
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.60984300
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.63978625
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.23393719
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.71298524
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.36671925
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.34726915
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.99292044
12* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.74833027
13AR_21909140_ChIP-Seq_LNCAP_Human2.44017263
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.28767591
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.10688065
16GATA1_22025678_ChIP-Seq_K562_Human2.09134433
17* PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.04596173
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.01639523
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.5080729
20CLOCK_20551151_ChIP-Seq_293T_Human1.97848271
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.87675842
22* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.80970973
23E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77734489
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.77318910
25* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.76630015
26TP63_17297297_ChIP-ChIP_HaCaT_Human1.75156088
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71220748
28* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71083620
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.66296448
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.64601899
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.62402789
32* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61114781
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.60936567
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52924731
35NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.51472577
36E2F7_22180533_ChIP-Seq_HELA_Human1.46082244
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45637942
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.42020930
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40948524
40GATA4_21415370_ChIP-Seq_HL-1_Mouse1.40434486
41* FOXA2_19822575_ChIP-Seq_HepG2_Human1.37411324
42NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.36624194
43TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34708865
44DCP1A_22483619_ChIP-Seq_HELA_Human1.34060203
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33145181
46* HNF4A_19822575_ChIP-Seq_HepG2_Human1.32650499
47* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31440528
48HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29609290
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29274612
50RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28968985
51SOX17_20123909_ChIP-Seq_XEN_Mouse1.28182824
52EOMES_21245162_ChIP-Seq_HESCs_Human1.27844069
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27215184
54ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.27116733
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27049000
56SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27049000
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23670864
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22136588
59SOX2_20726797_ChIP-Seq_SW620_Human1.21146526
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19739416
61ATF3_27146783_Chip-Seq_COLON_Human1.18185220
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.17738268
63RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17373496
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15503638
65TBX5_21415370_ChIP-Seq_HL-1_Mouse1.14713353
66TFEB_21752829_ChIP-Seq_HELA_Human1.14655935
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12474973
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11755591
69FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11404088
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08971388
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07981989
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07363788
73ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05694103
74EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05373958
75NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05066534
76* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03352398
77IRF8_22096565_ChIP-ChIP_GC-B_Human1.02671469
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.02134764
79MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01009231
80* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00814173
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00317680
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98669040
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98635968
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97490044
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97319568
86CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95889502
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95533341
88GATA4_25053715_ChIP-Seq_YYC3_Human0.95469424
89ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94740316
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92980366
91TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.92644292
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86935702
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83367711
94ESR1_21235772_ChIP-Seq_MCF-7_Human0.82668268
95ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82578673
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82033331
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.81800114
98HTT_18923047_ChIP-ChIP_STHdh_Human0.81687889
99ZNF263_19887448_ChIP-Seq_K562_Human0.80958469
100* IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.80899231
101LXR_22292898_ChIP-Seq_THP-1_Human0.80447691
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79829214
103TBX20_22328084_ChIP-Seq_HEART_Mouse0.75653875
104TBX20_22080862_ChIP-Seq_HEART_Mouse0.75653875
105FOXO3_23340844_ChIP-Seq_DLD1_Human0.75476215
106CDX2_20551321_ChIP-Seq_CACO-2_Human0.74451044
107AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72162369
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70662258
109AUTS2_25519132_ChIP-Seq_293T-REX_Human0.70368531
110BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69368855
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69130545
112KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.68798209
113KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.68798209
114KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.68798209
115RACK7_27058665_Chip-Seq_MCF-7_Human0.67964188
116NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.67761296
117RARA_24833708_ChIP-Seq_LIVER_Mouse0.66930375
118TCF3_18692474_ChIP-Seq_MEFs_Mouse0.65506086
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65080633
120GATA6_25053715_ChIP-Seq_YYC3_Human0.64245053
121ESET_19884257_ChIP-Seq_ESCs_Mouse0.64070492
122* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.62774912
123RARB_24833708_ChIP-Seq_LIVER_Mouse0.62409275
124GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.60433810
125CEBPB_22108803_ChIP-Seq_LS180_Human0.60425219
126NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.60241096
127ESR1_20079471_ChIP-ChIP_T-47D_Human0.60133303
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.59909004
129CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.59724778
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.59146175
131SALL4_18804426_ChIP-ChIP_XEN_Mouse0.59013656
132SOX2_18692474_ChIP-Seq_MEFs_Mouse0.58158543
133BCOR_27268052_Chip-Seq_Bcells_Human0.58114882
134AR_20517297_ChIP-Seq_VCAP_Human0.57853387
135PPAR_26484153_Chip-Seq_NCI-H1993_Human0.55976393
136CTCF_21964334_Chip-Seq_Bcells_Human0.55888105
137HIF1A_21447827_ChIP-Seq_MCF-7_Human0.55400877
138GATA3_24758297_ChIP-Seq_MCF-7_Human0.55269801
139RAD21_21589869_ChIP-Seq_MESCs_Mouse0.55038766
140PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.53737432
141Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.53597092
142TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.53438784
143GATA1_19941827_ChIP-Seq_MEL_Mouse0.53001625
144FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52276445
145SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.51851342
146OCT4_18692474_ChIP-Seq_MEFs_Mouse0.51648316
147SCL_19346495_ChIP-Seq_HPC-7_Human0.51541055
148GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.51374769
149CSB_26484114_Chip-Seq_FIBROBLAST_Human0.50439578
150SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.50393377
151IRF1_19129219_ChIP-ChIP_H3396_Human0.49090507
152P68_20966046_ChIP-Seq_HELA_Human0.47547578
153ERG_20517297_ChIP-Seq_VCAP_Human0.47534844
154EGR1_19032775_ChIP-ChIP_M12_Human0.47490257
155GATA1_19941826_ChIP-Seq_K562_Human0.47324189
156TET1_21451524_ChIP-Seq_MESCs_Mouse0.46827556

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.27937481
2MP0005360_urolithiasis7.00001890
3MP0005365_abnormal_bile_salt5.53159426
4MP0005085_abnormal_gallbladder_physiolo5.42767459
5MP0008875_abnormal_xenobiotic_pharmacok4.51021117
6MP0003806_abnormal_nucleotide_metabolis4.08165260
7MP0003252_abnormal_bile_duct3.41201358
8MP0000751_myopathy3.24254805
9MP0010329_abnormal_lipoprotein_level3.22421582
10MP0005332_abnormal_amino_acid3.14402650
11MP0003195_calcinosis2.84422947
12MP0009840_abnormal_foam_cell2.62434906
13MP0004272_abnormal_basement_membrane2.56286007
14MP0008438_abnormal_cutaneous_collagen2.53010642
15MP0005083_abnormal_biliary_tract2.47163689
16MP0003950_abnormal_plasma_membrane2.39509374
17MP0001666_abnormal_nutrient_absorption2.28372483
18MP0004019_abnormal_vitamin_homeostasis2.24671753
19MP0003191_abnormal_cellular_cholesterol2.18957407
20MP0009780_abnormal_chondrocyte_physiolo2.17312771
21MP0004233_abnormal_muscle_weight2.14199532
22MP0002118_abnormal_lipid_homeostasis2.11099569
23MP0000609_abnormal_liver_physiology2.09674712
24MP0005319_abnormal_enzyme/_coenzyme2.02630772
25MP0002138_abnormal_hepatobiliary_system1.95684112
26MP0005670_abnormal_white_adipose1.91581645
27MP0003011_delayed_dark_adaptation1.80848063
28MP0009643_abnormal_urine_homeostasis1.79737197
29MP0005584_abnormal_enzyme/coenzyme_acti1.78422796
30MP0002877_abnormal_melanocyte_morpholog1.77363382
31MP0003186_abnormal_redox_activity1.74549357
32MP0006036_abnormal_mitochondrial_physio1.74207302
33MP0010234_abnormal_vibrissa_follicle1.72369017
34MP0000759_abnormal_skeletal_muscle1.64487621
35MP0001881_abnormal_mammary_gland1.63248602
36MP0003941_abnormal_skin_development1.63100170
37MP0004130_abnormal_muscle_cell1.60125822
38MP0004043_abnormal_pH_regulation1.58117624
39MP0002837_dystrophic_cardiac_calcinosis1.53212097
40MP0002254_reproductive_system_inflammat1.52020540
41MP0001764_abnormal_homeostasis1.50675141
42MP0000750_abnormal_muscle_regeneration1.49940017
43MP0003705_abnormal_hypodermis_morpholog1.49434416
44MP0003566_abnormal_cell_adhesion1.42930417
45MP0000013_abnormal_adipose_tissue1.42890581
46MP0003868_abnormal_feces_composition1.40726082
47MP0005666_abnormal_adipose_tissue1.37983586
48MP0010352_gastrointestinal_tract_polyps1.34899848
49MP0004145_abnormal_muscle_electrophysio1.33211335
50MP0000003_abnormal_adipose_tissue1.30502854
51MP0010030_abnormal_orbit_morphology1.30400649
52MP0005257_abnormal_intraocular_pressure1.24983707
53MP0005451_abnormal_body_composition1.22791475
54MP0006035_abnormal_mitochondrial_morpho1.22670463
55MP0005636_abnormal_mineral_homeostasis1.22192404
56MP0002108_abnormal_muscle_morphology1.19785506
57MP0002106_abnormal_muscle_physiology1.18224136
58MP0000598_abnormal_liver_morphology1.16104340
59MP0002971_abnormal_brown_adipose1.15835782
60MP0005369_muscle_phenotype1.13855676
61MP0000733_abnormal_muscle_development1.11511683
62MP0005023_abnormal_wound_healing1.07799372
63MP0001756_abnormal_urination1.04138839
64MP0003656_abnormal_erythrocyte_physiolo1.03158697
65MP0003646_muscle_fatigue1.02003779
66MP0005266_abnormal_metabolism1.01872972
67MP0002078_abnormal_glucose_homeostasis1.00890602
68MP0005647_abnormal_sex_gland1.00082091
69MP0005535_abnormal_body_temperature0.95097867
70MP0002060_abnormal_skin_morphology0.93543698
71MP0009764_decreased_sensitivity_to0.92497322
72MP0005330_cardiomyopathy0.92401407
73MP0002896_abnormal_bone_mineralization0.91040062
74MP0009763_increased_sensitivity_to0.89541002
75MP0004264_abnormal_extraembryonic_tissu0.89412350
76MP0010368_abnormal_lymphatic_system0.89094494
77MP0004185_abnormal_adipocyte_glucose0.88524547
78MP0005334_abnormal_fat_pad0.87761624
79MP0005376_homeostasis/metabolism_phenot0.87598277
80MP0000627_abnormal_mammary_gland0.86361776
81MP0009642_abnormal_blood_homeostasis0.85403500
82MP0009697_abnormal_copulation0.83007481
83MP0001661_extended_life_span0.82555050
84MP0002136_abnormal_kidney_physiology0.82136627
85MP0008469_abnormal_protein_level0.81727831
86MP0002332_abnormal_exercise_endurance0.81458643
87MP0005503_abnormal_tendon_morphology0.80496489
88MP0005275_abnormal_skin_tensile0.79097835
89MP0002970_abnormal_white_adipose0.78460088
90MP0002269_muscular_atrophy0.76316745
91MP0005171_absent_coat_pigmentation0.75094432
92MP0004858_abnormal_nervous_system0.74437479
93MP0008961_abnormal_basal_metabolism0.73941433
94MP0000762_abnormal_tongue_morphology0.73708067
95MP0002876_abnormal_thyroid_physiology0.73526321
96MP0009115_abnormal_fat_cell0.73281757
97MP0005623_abnormal_meninges_morphology0.72124230
98MP0001915_intracranial_hemorrhage0.71157725
99MP0005375_adipose_tissue_phenotype0.69505589
100MP0001765_abnormal_ion_homeostasis0.69368072
101MP0000467_abnormal_esophagus_morphology0.68529377
102MP0005084_abnormal_gallbladder_morpholo0.66726787
103MP0001727_abnormal_embryo_implantation0.66500234
104MP0003718_maternal_effect0.65591194
105MP0001243_abnormal_dermal_layer0.65380045
106MP0009765_abnormal_xenobiotic_induced0.65137345
107MP0000604_amyloidosis0.65038755
108MP0005197_abnormal_uvea_morphology0.63461892
109MP0008775_abnormal_heart_ventricle0.61909386
110MP0004036_abnormal_muscle_relaxation0.61317836
111MP0005448_abnormal_energy_balance0.60828923
112MP0000230_abnormal_systemic_arterial0.60544977
113MP0005220_abnormal_exocrine_pancreas0.60472471
114MP0004084_abnormal_cardiac_muscle0.57852079
115MP0001853_heart_inflammation0.52866401
116MP0000749_muscle_degeneration0.52354159
117MP0003221_abnormal_cardiomyocyte_apopto0.51310888
118MP0004215_abnormal_myocardial_fiber0.50352137
119MP0003953_abnormal_hormone_level0.49530107
120MP0004087_abnormal_muscle_fiber0.48735433
121MP0003690_abnormal_glial_cell0.47156698
122MP0005385_cardiovascular_system_phenoty0.46996689
123MP0001544_abnormal_cardiovascular_syste0.46996689
124MP0003959_abnormal_lean_body0.46698313
125MP0003724_increased_susceptibility_to0.46246785
126MP0005075_abnormal_melanosome_morpholog0.46113937
127MP0005408_hypopigmentation0.44961619
128MP0005058_abnormal_lysosome_morphology0.44099583
129MP0010630_abnormal_cardiac_muscle0.42818454
130MP0004782_abnormal_surfactant_physiolog0.41980836
131MP0005452_abnormal_adipose_tissue0.41836124
132MP0000747_muscle_weakness0.40412850
133MP0002928_abnormal_bile_duct0.40389318
134MP0003638_abnormal_response/metabolism_0.40296177
135MP0006138_congestive_heart_failure0.40146945
136MP0005165_increased_susceptibility_to0.39175538
137MP0002796_impaired_skin_barrier0.38795268
138MP0002972_abnormal_cardiac_muscle0.38668188
139MP0005620_abnormal_muscle_contractility0.37595484

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.16101724
2Intrahepatic cholestasis (HP:0001406)5.71101478
3Hyperglycinuria (HP:0003108)5.36689451
4Deep venous thrombosis (HP:0002625)5.31719937
5Xanthomatosis (HP:0000991)5.30535134
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.02896575
7Hyperammonemia (HP:0001987)4.96163913
8Ketosis (HP:0001946)4.95694492
9Abnormality of glycine metabolism (HP:0010895)4.88347281
10Abnormality of serine family amino acid metabolism (HP:0010894)4.88347281
11Nemaline bodies (HP:0003798)4.76039841
12Exercise-induced myalgia (HP:0003738)4.65309086
13Muscle fiber inclusion bodies (HP:0100299)4.54982916
14Hyperglycinemia (HP:0002154)4.53449456
15Hypoglycemic coma (HP:0001325)4.52917104
16Exercise-induced muscle cramps (HP:0003710)4.50337604
17Hyperlipoproteinemia (HP:0010980)4.48793003
18Prolonged partial thromboplastin time (HP:0003645)4.48352638
19Hypobetalipoproteinemia (HP:0003563)4.46434292
20Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.46037927
21Ketoacidosis (HP:0001993)4.36771617
22Abnormality of fatty-acid metabolism (HP:0004359)4.29501065
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.16083690
24Complement deficiency (HP:0004431)4.04957391
25Gout (HP:0001997)3.95684025
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.87606340
27Hypolipoproteinemia (HP:0010981)3.75226935
28Abnormality of sulfur amino acid metabolism (HP:0004339)3.68560957
29Dicarboxylic aciduria (HP:0003215)3.68412489
30Abnormality of dicarboxylic acid metabolism (HP:0010995)3.68412489
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.67487722
32Hypoalphalipoproteinemia (HP:0003233)3.64231796
33Type 1 muscle fiber predominance (HP:0003803)3.62721378
34Epidermoid cyst (HP:0200040)3.57093084
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.52864116
36Abnormality of the intrinsic pathway (HP:0010989)3.48491392
37Joint hemorrhage (HP:0005261)3.44528619
38Distal lower limb muscle weakness (HP:0009053)3.36619741
39Abnormality of purine metabolism (HP:0004352)3.36466606
40Abnormality of methionine metabolism (HP:0010901)3.35389509
41Vertebral compression fractures (HP:0002953)3.30083269
42Metabolic acidosis (HP:0001942)3.28699519
43Delayed CNS myelination (HP:0002188)3.26042762
44Abnormality of the common coagulation pathway (HP:0010990)3.20419665
45Generalized aminoaciduria (HP:0002909)3.19997180
46Protrusio acetabuli (HP:0003179)3.17914277
47Abnormality of nucleobase metabolism (HP:0010932)3.17705390
48Abnormality of serum amino acid levels (HP:0003112)3.17459581
49Fat malabsorption (HP:0002630)3.14937539
50Lethargy (HP:0001254)3.08643079
51Proximal tubulopathy (HP:0000114)3.03680246
52Asymmetric septal hypertrophy (HP:0001670)3.01301889
53Neck muscle weakness (HP:0000467)2.96779874
54Hypercholesterolemia (HP:0003124)2.94051949
55Increased purine levels (HP:0004368)2.89492419
56Hyperuricemia (HP:0002149)2.89492419
57Premature rupture of membranes (HP:0001788)2.88790711
58Abnormality of complement system (HP:0005339)2.87056769
59Hypochromic microcytic anemia (HP:0004840)2.85074930
60Cerebral edema (HP:0002181)2.85053865
61Hyperbilirubinemia (HP:0002904)2.85027367
62Hyperinsulinemic hypoglycemia (HP:0000825)2.81680852
63Myoglobinuria (HP:0002913)2.80296744
64Abnormality of pyrimidine metabolism (HP:0004353)2.80182958
65Skin nodule (HP:0200036)2.78532448
66Muscle stiffness (HP:0003552)2.78274533
67EMG: myopathic abnormalities (HP:0003458)2.76268848
68Vomiting (HP:0002013)2.70352480
69Ragged-red muscle fibers (HP:0003200)2.62507797
70Increased connective tissue (HP:0009025)2.62109330
71Muscle hypertrophy of the lower extremities (HP:0008968)2.60844615
72Abnormality of the calf musculature (HP:0001430)2.60119900
73Hepatocellular carcinoma (HP:0001402)2.58182359
74Centrally nucleated skeletal muscle fibers (HP:0003687)2.56861340
75Hyporeflexia of lower limbs (HP:0002600)2.55486419
76Abnormal cartilage morphology (HP:0002763)2.54430104
77Calf muscle hypertrophy (HP:0008981)2.52886927
78Hypoglycemic seizures (HP:0002173)2.51859003
79Malnutrition (HP:0004395)2.50085108
80Myopathic facies (HP:0002058)2.48969598
81Conjugated hyperbilirubinemia (HP:0002908)2.44938549
82Steatorrhea (HP:0002570)2.38240070
83Sudden death (HP:0001699)2.35578742
84Irritability (HP:0000737)2.35278608
85Myocardial infarction (HP:0001658)2.34675581
86Abnormality of skeletal muscle fiber size (HP:0012084)2.33992116
87Vascular calcification (HP:0004934)2.33557393
88Reduced subcutaneous adipose tissue (HP:0003758)2.32790593
89Late onset (HP:0003584)2.32309809
90Abnormality of proline metabolism (HP:0010907)2.32157641
91Hydroxyprolinuria (HP:0003080)2.32157641
92Right ventricular cardiomyopathy (HP:0011663)2.32128734
93Mitral stenosis (HP:0001718)2.31228428
94Cholecystitis (HP:0001082)2.24506010
95Abnormality of urine glucose concentration (HP:0011016)2.24427536
96Glycosuria (HP:0003076)2.24427536
97Alkalosis (HP:0001948)2.23857762
98Nausea (HP:0002018)2.23543910
99Pancreatitis (HP:0001733)2.23218851
100Dilated cardiomyopathy (HP:0001644)2.21079199
101Neonatal onset (HP:0003623)2.19065534
102Reduced antithrombin III activity (HP:0001976)2.18500815
103Spastic diplegia (HP:0001264)2.16908781
104Enlarged kidneys (HP:0000105)2.13970827
105Rhabdomyolysis (HP:0003201)2.13632402
106Multiple enchondromatosis (HP:0005701)2.12710375
107Hepatic necrosis (HP:0002605)2.11832929
108Cholelithiasis (HP:0001081)2.11000217
109Abnormality of the Achilles tendon (HP:0005109)2.10749990
110Ulnar deviation of the wrist (HP:0003049)2.09670843
111Abnormal gallbladder morphology (HP:0012437)2.08495228
112Increased muscle lipid content (HP:0009058)2.06256055
113Cardiovascular calcification (HP:0011915)2.05825477
114Increased variability in muscle fiber diameter (HP:0003557)2.04512973
115Lipoatrophy (HP:0100578)2.03728602
116Mildly elevated creatine phosphokinase (HP:0008180)2.03171457
117Osteolytic defects of the hand bones (HP:0009699)2.01027482
118Osteolytic defects of the phalanges of the hand (HP:0009771)2.01027482
119Sensorimotor neuropathy (HP:0007141)2.00338850
120Ventricular tachycardia (HP:0004756)1.99473598
121Systemic lupus erythematosus (HP:0002725)1.97323865
122Renal cortical cysts (HP:0000803)1.95083519
123Abnormality of glycolysis (HP:0004366)1.94127290
124Increased serum pyruvate (HP:0003542)1.94127290
125Abnormal enzyme/coenzyme activity (HP:0012379)1.92590614
126Hypokinesia (HP:0002375)1.92426993
127Distal arthrogryposis (HP:0005684)1.91993079
128Round ear (HP:0100830)1.91870917
129Progressive muscle weakness (HP:0003323)1.91354816
130Brushfield spots (HP:0001088)1.90184041
131Subaortic stenosis (HP:0001682)1.89594410
132Abnormality of the left ventricular outflow tract (HP:0011103)1.89594410
133Spinal rigidity (HP:0003306)1.89244201
134Back pain (HP:0003418)1.88920746
135Hypertriglyceridemia (HP:0002155)1.88729232
136Breech presentation (HP:0001623)1.87718955
137Short nail (HP:0001799)1.87640246
138Rickets (HP:0002748)1.87541921
139Acute encephalopathy (HP:0006846)1.87017464
140Limb-girdle muscle atrophy (HP:0003797)1.86954045
141Vascular tortuosity (HP:0004948)1.86410726
142Bundle branch block (HP:0011710)1.85365162
143Esophageal varix (HP:0002040)1.84850384
144Generalized amyotrophy (HP:0003700)1.84459394
145Abnormality of transition element cation homeostasis (HP:0011030)1.84225914
146Abnormal delivery (HP:0001787)1.82076528
147Abnormality of iron homeostasis (HP:0011031)1.81821565
148Achilles tendon contracture (HP:0001771)1.80897154
149Methylmalonic aciduria (HP:0012120)1.80799942
150Elevated hepatic transaminases (HP:0002910)1.80689604
151Spontaneous abortion (HP:0005268)1.77695723
152Symptomatic seizures (HP:0011145)1.76948964
153Muscle fiber splitting (HP:0003555)1.76618457
154Popliteal pterygium (HP:0009756)1.76593511
155Arterial tortuosity (HP:0005116)1.76127012
156Abnormal gallbladder physiology (HP:0012438)1.75867149
157Rimmed vacuoles (HP:0003805)1.72431679

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.24347971
2ERN14.92080196
3SIK13.23438767
4EPHA23.02480251
5TESK12.76845058
6PBK2.75847961
7MAP3K122.71448511
8SCYL22.64820264
9FGFR42.62260796
10TRIB32.60159769
11PDK32.46331656
12PDK42.46331656
13LIMK12.41674732
14PKN22.39354636
15INSRR2.33035472
16EIF2AK12.06066652
17FLT32.03617557
18WNK41.94959704
19PAK41.93876099
20GRK61.92187886
21TGFBR21.81735848
22MST1R1.66894136
23WNK31.62428138
24CDK121.58701973
25PINK11.57412441
26MAPK111.53725574
27MAP2K41.46866035
28ARAF1.42378298
29MUSK1.40525019
30CSF1R1.36678062
31NEK11.36568995
32ERBB41.36238755
33PDK21.35956548
34VRK21.34798872
35MAP3K71.33963705
36LATS21.30282294
37NME11.28977491
38TAOK31.28770812
39EIF2AK31.27584601
40TIE11.26224184
41MAP2K31.25915209
42PIK3CG1.23022883
43STK38L1.18441697
44MAP3K21.18290733
45GRK11.18124807
46PRKAA21.14729246
47GRK51.10105898
48MAPK71.08796737
49KDR1.08766704
50EEF2K1.08162326
51DMPK1.06121997
52MAPK121.04539405
53TYK21.03755918
54BUB11.00133856
55TESK20.98185431
56OBSCN0.96938332
57JAK20.96159177
58MYLK0.95330783
59OXSR10.94659452
60TTN0.93571915
61RPS6KB20.92720749
62CAMK2G0.92363878
63ILK0.91527389
64LMTK20.91181897
65MAP3K100.90107477
66NEK90.89285215
67FER0.89141603
68PIM20.88143006
69CAMK1D0.87577580
70LATS10.86582708
71PRKAA10.83334035
72ABL20.80512126
73GRK70.80476619
74ICK0.80193057
75DDR20.80025556
76STK160.79367628
77MATK0.79200581
78MAP2K60.78993754
79FGFR30.77552753
80CDK80.74815582
81MAPK40.73160108
82MAP3K30.71788360
83ADRBK20.71598283
84RIPK10.71137049
85PTK60.70546809
86PHKG10.69279290
87PHKG20.69279290
88CAMK2D0.68740024
89CAMK40.68521813
90MST40.67697005
91WNK10.65711575
92MET0.64477243
93TRPM70.64442057
94KSR20.64161902
95PRKACG0.63859306
96RAF10.63275440
97STK100.62021906
98NME20.60110640
99PRKG20.58469859
100TBK10.57232875
101CSK0.56755762
102MAP4K20.56604659
103PDK10.56338196
104NTRK10.54764514
105GSK3A0.53189795
106ERBB30.52802633
107PDPK10.52745330
108MAPKAPK30.52425214
109SRPK10.51436950
110MAPKAPK50.50082458
111JAK10.49197649
112BRSK10.48558220
113IGF1R0.47571536
114EPHB10.47485417
115PAK20.47310967
116CDK70.45926760
117ERBB20.45716136
118DYRK1B0.45329988
119AURKB0.44392762
120PTK20.44203203
121FRK0.43549957
122LRRK20.42870333
123AKT20.42822644
124CCNB10.41338778
125MOS0.41070148
126SMG10.41059444
127DAPK10.40727664
128CDK40.40616460
129WEE10.40265953
130PAK30.39633547
131MTOR0.39144674
132PIK3CA0.37426869
133DAPK30.36887331
134MAP3K50.36452058
135CDK60.36243311
136SGK30.36234681
137KIT0.35760265
138BRSK20.35593462
139MAP3K80.35173829
140STK380.34833012
141PAK10.34793507
142MAP3K110.34476780
143JAK30.34116382
144IRAK30.31948954
145STK30.30267532
146PDGFRA0.29990769
147TTK0.29866272
148TAOK20.29273216
149MAP2K10.28862067
150PRKCZ0.28419994
151ROCK20.27898849
152ZAP700.27845360
153STK390.27009362
154PLK10.26350482
155AKT30.26186146
156CAMK2B0.25607483

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.61069044
2* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.06913704
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.03621009
4Nitrogen metabolism_Homo sapiens_hsa009103.01980076
5Fatty acid degradation_Homo sapiens_hsa000713.01885565
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.99567237
7Propanoate metabolism_Homo sapiens_hsa006402.87141635
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.86153252
9Tryptophan metabolism_Homo sapiens_hsa003802.73091065
10Arginine biosynthesis_Homo sapiens_hsa002202.55892756
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.43439178
12Butanoate metabolism_Homo sapiens_hsa006502.43295043
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.41354389
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.33117771
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.31952539
16Fatty acid metabolism_Homo sapiens_hsa012122.30653703
17Peroxisome_Homo sapiens_hsa041462.21078248
18PPAR signaling pathway_Homo sapiens_hsa033202.09592564
19Complement and coagulation cascades_Homo sapiens_hsa046102.03823021
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.94371583
21beta-Alanine metabolism_Homo sapiens_hsa004101.93203107
22Pyruvate metabolism_Homo sapiens_hsa006201.83301050
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.77002028
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75447513
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.74445673
26Carbon metabolism_Homo sapiens_hsa012001.72619762
27Chemical carcinogenesis_Homo sapiens_hsa052041.65808700
28Proteasome_Homo sapiens_hsa030501.59143012
29Fatty acid elongation_Homo sapiens_hsa000621.55855477
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55266386
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53699864
32Histidine metabolism_Homo sapiens_hsa003401.53413526
33Caffeine metabolism_Homo sapiens_hsa002321.50962929
34Selenocompound metabolism_Homo sapiens_hsa004501.47361892
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.47080115
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.45570261
37Biosynthesis of amino acids_Homo sapiens_hsa012301.39633301
38Phenylalanine metabolism_Homo sapiens_hsa003601.38780881
39Sulfur metabolism_Homo sapiens_hsa009201.37453881
40Retinol metabolism_Homo sapiens_hsa008301.36080031
41Starch and sucrose metabolism_Homo sapiens_hsa005001.33697040
42Bile secretion_Homo sapiens_hsa049761.33394454
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27127801
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.24183425
45Tyrosine metabolism_Homo sapiens_hsa003501.24058654
46Folate biosynthesis_Homo sapiens_hsa007901.23763873
47Vitamin B6 metabolism_Homo sapiens_hsa007501.17376155
48Staphylococcus aureus infection_Homo sapiens_hsa051501.15190466
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15041590
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.13467709
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06644293
52Fat digestion and absorption_Homo sapiens_hsa049751.04705479
53Arginine and proline metabolism_Homo sapiens_hsa003301.01581323
54Glycerolipid metabolism_Homo sapiens_hsa005610.98281532
55ABC transporters_Homo sapiens_hsa020100.96618926
56Lysine degradation_Homo sapiens_hsa003100.93904270
57Sulfur relay system_Homo sapiens_hsa041220.93833358
58Vitamin digestion and absorption_Homo sapiens_hsa049770.85398290
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82245885
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.81136875
61Pentose phosphate pathway_Homo sapiens_hsa000300.80889275
62Glutathione metabolism_Homo sapiens_hsa004800.77080094
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75738007
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75432127
65Fatty acid biosynthesis_Homo sapiens_hsa000610.74488860
66Fructose and mannose metabolism_Homo sapiens_hsa000510.71755089
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66952106
68Steroid biosynthesis_Homo sapiens_hsa001000.66813101
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63587071
70One carbon pool by folate_Homo sapiens_hsa006700.60217087
71N-Glycan biosynthesis_Homo sapiens_hsa005100.58788161
72Galactose metabolism_Homo sapiens_hsa000520.56795235
73* Metabolic pathways_Homo sapiens_hsa011000.55498068
74Mismatch repair_Homo sapiens_hsa034300.54086052
75Dilated cardiomyopathy_Homo sapiens_hsa054140.49586713
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49084726
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.43149878
78DNA replication_Homo sapiens_hsa030300.42820108
79Nucleotide excision repair_Homo sapiens_hsa034200.41597859
80Insulin resistance_Homo sapiens_hsa049310.39964467
81Pyrimidine metabolism_Homo sapiens_hsa002400.39865173
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39551485
83Huntingtons disease_Homo sapiens_hsa050160.35720309
84ECM-receptor interaction_Homo sapiens_hsa045120.33061197
85Base excision repair_Homo sapiens_hsa034100.31721584
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31289836
87Thyroid cancer_Homo sapiens_hsa052160.30238204
88Linoleic acid metabolism_Homo sapiens_hsa005910.28716911
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28631844
90Vibrio cholerae infection_Homo sapiens_hsa051100.26782354
91AMPK signaling pathway_Homo sapiens_hsa041520.23491802
92Sphingolipid metabolism_Homo sapiens_hsa006000.23113067
93Circadian rhythm_Homo sapiens_hsa047100.22524058
94Focal adhesion_Homo sapiens_hsa045100.22406592
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.19553576
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19171519
97Glucagon signaling pathway_Homo sapiens_hsa049220.17614723
98Arachidonic acid metabolism_Homo sapiens_hsa005900.13012586
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.06164599
100Oxidative phosphorylation_Homo sapiens_hsa001900.05604826
101Prion diseases_Homo sapiens_hsa050200.04428712
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.03735823
103Parkinsons disease_Homo sapiens_hsa050120.03694328
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.03191005
105Other glycan degradation_Homo sapiens_hsa005110.01664664
106Insulin signaling pathway_Homo sapiens_hsa049100.00896694
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.00800295
108Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1840775
109Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1634751
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.1606288
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1487014
112Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1426862
113Cardiac muscle contraction_Homo sapiens_hsa04260-0.1349757
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1110247
115Alzheimers disease_Homo sapiens_hsa05010-0.0978787
116Regulation of autophagy_Homo sapiens_hsa04140-0.0874400
117Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0548187
118Renin-angiotensin system_Homo sapiens_hsa04614-0.0193653
119Protein digestion and absorption_Homo sapiens_hsa04974-0.0077659

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