HIBCH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the enzyme responsible for hydrolysis of both HIBYL-CoA and beta-hydroxypropionyl-CoA. Mutations in this gene have been associated with 3-hyroxyisobutyryl-CoA hydrolase deficiency. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.28489849
2L-phenylalanine catabolic process (GO:0006559)6.28489849
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.09149152
4L-phenylalanine metabolic process (GO:0006558)6.09149152
5aromatic amino acid family catabolic process (GO:0009074)5.60875262
6alpha-linolenic acid metabolic process (GO:0036109)5.27406677
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.24954302
8lysine catabolic process (GO:0006554)5.17534349
9lysine metabolic process (GO:0006553)5.17534349
10glyoxylate metabolic process (GO:0046487)5.08958781
11indolalkylamine catabolic process (GO:0046218)5.03592485
12tryptophan catabolic process (GO:0006569)5.03592485
13indole-containing compound catabolic process (GO:0042436)5.03592485
14fatty acid beta-oxidation (GO:0006635)5.00110142
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.98680843
16bile acid biosynthetic process (GO:0006699)4.94143892
17tryptophan metabolic process (GO:0006568)4.88107853
18* valine metabolic process (GO:0006573)4.88028858
19regulation of triglyceride catabolic process (GO:0010896)4.87337257
20kynurenine metabolic process (GO:0070189)4.84978951
21cysteine metabolic process (GO:0006534)4.81887088
22sulfur amino acid catabolic process (GO:0000098)4.77012199
23complement activation, alternative pathway (GO:0006957)4.68081711
24amino-acid betaine metabolic process (GO:0006577)4.67753089
25* branched-chain amino acid catabolic process (GO:0009083)4.67042742
26fatty acid oxidation (GO:0019395)4.66512292
27lipid oxidation (GO:0034440)4.60070329
28fatty acid catabolic process (GO:0009062)4.59319004
29regulation of sequestering of triglyceride (GO:0010889)4.55134759
30acetyl-CoA metabolic process (GO:0006084)4.54396103
31short-chain fatty acid metabolic process (GO:0046459)4.44281174
32urea metabolic process (GO:0019627)4.37142112
33urea cycle (GO:0000050)4.37142112
34serine family amino acid catabolic process (GO:0009071)4.35615267
35biotin metabolic process (GO:0006768)4.35445315
36homocysteine metabolic process (GO:0050667)4.33109088
37positive regulation of fatty acid beta-oxidation (GO:0032000)4.32001383
38DNA double-strand break processing (GO:0000729)4.31455616
39* branched-chain amino acid metabolic process (GO:0009081)4.31284117
40monocarboxylic acid catabolic process (GO:0072329)4.27441714
41fatty acid transmembrane transport (GO:1902001)4.25767280
42* alpha-amino acid catabolic process (GO:1901606)4.23742589
432-oxoglutarate metabolic process (GO:0006103)4.21557840
44ethanol oxidation (GO:0006069)4.20548216
45aromatic amino acid family metabolic process (GO:0009072)4.19051142
46bile acid metabolic process (GO:0008206)4.17430119
47triglyceride homeostasis (GO:0070328)4.16550056
48acylglycerol homeostasis (GO:0055090)4.16550056
49regulation of protein activation cascade (GO:2000257)4.15599622
50high-density lipoprotein particle remodeling (GO:0034375)4.13383957
51cellular ketone body metabolic process (GO:0046950)4.11983819
52tyrosine metabolic process (GO:0006570)4.08484701
53nitrogen cycle metabolic process (GO:0071941)4.04703716
54carnitine metabolic process (GO:0009437)4.04341263
55positive regulation of fatty acid oxidation (GO:0046321)4.02563072
56* cellular amino acid catabolic process (GO:0009063)4.02120468
57protein carboxylation (GO:0018214)4.00614787
58peptidyl-glutamic acid carboxylation (GO:0017187)4.00614787
59negative regulation of fibrinolysis (GO:0051918)3.98721300
60* carboxylic acid catabolic process (GO:0046395)3.97768955
61* organic acid catabolic process (GO:0016054)3.97768955
62coenzyme catabolic process (GO:0009109)3.96506234
63carnitine shuttle (GO:0006853)3.94097577
64plasma lipoprotein particle clearance (GO:0034381)3.93925207
65regulation of complement activation (GO:0030449)3.92929392
66regulation of fibrinolysis (GO:0051917)3.91087199
67positive regulation of lipid catabolic process (GO:0050996)3.84391530
68water-soluble vitamin biosynthetic process (GO:0042364)3.84325412
69protein-lipid complex remodeling (GO:0034368)3.83199614
70macromolecular complex remodeling (GO:0034367)3.83199614
71plasma lipoprotein particle remodeling (GO:0034369)3.83199614
72respiratory chain complex IV assembly (GO:0008535)3.81949286
73aspartate family amino acid catabolic process (GO:0009068)3.80137279
74cullin deneddylation (GO:0010388)3.80022826
75indolalkylamine metabolic process (GO:0006586)3.76432330
76cellular biogenic amine catabolic process (GO:0042402)3.76340201
77amine catabolic process (GO:0009310)3.76340201
78chromatin remodeling at centromere (GO:0031055)3.73827650
79proteasome assembly (GO:0043248)3.72314146
80reverse cholesterol transport (GO:0043691)3.65424721
81serine family amino acid metabolic process (GO:0009069)3.64548144
82CENP-A containing nucleosome assembly (GO:0034080)3.62701475
83protein neddylation (GO:0045116)3.62517993
84regulation of cholesterol esterification (GO:0010872)3.62133918
85cellular glucuronidation (GO:0052695)3.61639409
86triglyceride catabolic process (GO:0019433)3.57001781
87thioester metabolic process (GO:0035383)3.54232643
88acyl-CoA metabolic process (GO:0006637)3.54232643
89glycine metabolic process (GO:0006544)3.54014548
90ketone body metabolic process (GO:1902224)3.53341116
91cellular modified amino acid catabolic process (GO:0042219)3.53060511
92benzene-containing compound metabolic process (GO:0042537)3.52501753
93regulation of cholesterol metabolic process (GO:0090181)3.51213169
94regulation of fatty acid oxidation (GO:0046320)3.51043474
95replication fork processing (GO:0031297)3.50728443
96protein deneddylation (GO:0000338)3.48338826
97serine family amino acid biosynthetic process (GO:0009070)3.47680891
98thioester biosynthetic process (GO:0035384)3.45851663
99acyl-CoA biosynthetic process (GO:0071616)3.45851663
100acylglycerol catabolic process (GO:0046464)3.44463211
101neutral lipid catabolic process (GO:0046461)3.44463211
102imidazole-containing compound metabolic process (GO:0052803)3.43149375
103regulation of fatty acid beta-oxidation (GO:0031998)3.42835163
104tricarboxylic acid cycle (GO:0006099)3.41384407
105negative regulation of lipase activity (GO:0060192)3.41346230
106tricarboxylic acid metabolic process (GO:0072350)3.39363121
107phospholipid homeostasis (GO:0055091)3.37689467
108bile acid and bile salt transport (GO:0015721)3.37219878
109cytochrome complex assembly (GO:0017004)3.36360448
110phospholipid efflux (GO:0033700)3.35054171
111* small molecule catabolic process (GO:0044282)3.34322156
112protein complex biogenesis (GO:0070271)3.25578197
113establishment of protein localization to mitochondrial membrane (GO:0090151)3.24377907
114negative regulation of DNA-dependent DNA replication (GO:2000104)3.20260211
115exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19210940
116nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.18380918
117histone exchange (GO:0043486)3.18239024
118purine nucleobase biosynthetic process (GO:0009113)3.17460699
119intraciliary transport (GO:0042073)3.16495109
120signal peptide processing (GO:0006465)3.16375468
121mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.15638523
122mitochondrial respiratory chain complex assembly (GO:0033108)3.13773919
123histone H2A acetylation (GO:0043968)3.11909264
124tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.09149940
125RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.09149940
126mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04213249
127mitochondrial respiratory chain complex I assembly (GO:0032981)3.04213249
128NADH dehydrogenase complex assembly (GO:0010257)3.04213249
129mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.01860482
130L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.01079012
131platelet dense granule organization (GO:0060155)2.97352307
132regulation of mitotic spindle checkpoint (GO:1903504)2.97000196
133regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.97000196
134aldehyde catabolic process (GO:0046185)2.92076091
135L-methionine salvage (GO:0071267)2.91916823
136L-methionine biosynthetic process (GO:0071265)2.91916823
137amino acid salvage (GO:0043102)2.91916823
138lactate metabolic process (GO:0006089)2.91017099
139centriole replication (GO:0007099)2.89306883
140resolution of meiotic recombination intermediates (GO:0000712)2.88212823
141maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.84692673
142metaphase plate congression (GO:0051310)2.82456266
143kinetochore assembly (GO:0051382)2.80732416
144mitotic metaphase plate congression (GO:0007080)2.79082570
145nucleobase biosynthetic process (GO:0046112)2.78688997
146rRNA modification (GO:0000154)2.78130622
147response to pheromone (GO:0019236)2.76121743
148chaperone-mediated protein transport (GO:0072321)2.75347576
149negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.74423225
150recombinational repair (GO:0000725)2.73926336
151regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.73693427
152DNA damage response, detection of DNA damage (GO:0042769)2.72886443
153double-strand break repair via homologous recombination (GO:0000724)2.72502708
154kinetochore organization (GO:0051383)2.70561871
155DNA replication-independent nucleosome assembly (GO:0006336)2.70140318
156DNA replication-independent nucleosome organization (GO:0034724)2.70140318
157transcription elongation from RNA polymerase III promoter (GO:0006385)2.69152385
158termination of RNA polymerase III transcription (GO:0006386)2.69152385
159histone mRNA metabolic process (GO:0008334)2.64932380
160double-strand break repair via nonhomologous end joining (GO:0006303)2.64748865
161non-recombinational repair (GO:0000726)2.64748865
162peptidyl-histidine modification (GO:0018202)2.62797625
163DNA catabolic process, exonucleolytic (GO:0000738)2.62739186
164positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.62292335
165nonmotile primary cilium assembly (GO:0035058)2.59735870
166IMP biosynthetic process (GO:0006188)2.59104908
167regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.58119312
168synapsis (GO:0007129)2.55497877
169ATP synthesis coupled proton transport (GO:0015986)2.54451649
170energy coupled proton transport, down electrochemical gradient (GO:0015985)2.54451649
171anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.53994393
172protein K6-linked ubiquitination (GO:0085020)2.53338391
173somatic diversification of immune receptors via somatic mutation (GO:0002566)2.52744532
174somatic hypermutation of immunoglobulin genes (GO:0016446)2.52744532
175regulation of mitochondrial translation (GO:0070129)2.52458528
176spindle checkpoint (GO:0031577)2.51511764
177regulation of cellular amino acid metabolic process (GO:0006521)2.49690566
178somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.49139496
179isotype switching (GO:0045190)2.49139496
180somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.49139496
181regulation of nuclear cell cycle DNA replication (GO:0033262)2.48964580
182DNA replication checkpoint (GO:0000076)2.48789306
183negative regulation of DNA recombination (GO:0045910)2.48215569
184L-serine metabolic process (GO:0006563)2.47376647
185protein prenylation (GO:0018342)2.46629096
186prenylation (GO:0097354)2.46629096
187DNA ligation (GO:0006266)2.45978037
188detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.45509861
189postreplication repair (GO:0006301)2.44965476
190RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.43758008
191IMP metabolic process (GO:0046040)2.41423869
192mitotic spindle checkpoint (GO:0071174)2.40859834
193respiratory electron transport chain (GO:0022904)2.40621535
194pseudouridine synthesis (GO:0001522)2.40573988

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.58476529
2* RXR_22158963_ChIP-Seq_LIVER_Mouse7.22408721
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.21488010
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.10449677
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.57111622
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.72573710
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.52753632
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.16700251
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.83377977
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.35248943
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.05806512
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.80531209
13ZNF274_21170338_ChIP-Seq_K562_Hela2.68718463
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.63571630
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47737088
16IGF1R_20145208_ChIP-Seq_DFB_Human2.45694664
17FUS_26573619_Chip-Seq_HEK293_Human2.38060807
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36644199
19GATA1_22025678_ChIP-Seq_K562_Human2.36632259
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.36378460
21ELK1_19687146_ChIP-ChIP_HELA_Human2.33691280
22VDR_22108803_ChIP-Seq_LS180_Human2.30654545
23* FLI1_27457419_Chip-Seq_LIVER_Mouse2.29555369
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.28565864
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.24293480
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23723382
27EWS_26573619_Chip-Seq_HEK293_Human2.23422711
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16292736
29CLOCK_20551151_ChIP-Seq_293T_Human2.01480262
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.3801778
31GBX2_23144817_ChIP-Seq_PC3_Human1.99616394
32P300_19829295_ChIP-Seq_ESCs_Human1.95105185
33TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.94482496
34* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84958550
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83906528
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82985251
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75759040
38* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.74630443
39VDR_23849224_ChIP-Seq_CD4+_Human1.73926206
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72307120
41E2F7_22180533_ChIP-Seq_HELA_Human1.65887229
42* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.64939556
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62385576
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58315326
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54965966
46* EZH2_27294783_Chip-Seq_NPCs_Mouse1.52985215
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49935138
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48638699
49ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.48271200
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45858189
51* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45594014
52HTT_18923047_ChIP-ChIP_STHdh_Human1.45015692
53ER_23166858_ChIP-Seq_MCF-7_Human1.43462249
54FOXP3_21729870_ChIP-Seq_TREG_Human1.43462200
55MYC_18940864_ChIP-ChIP_HL60_Human1.42526975
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.41327927
57* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37594951
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37571387
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.33606328
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33301043
61CBP_20019798_ChIP-Seq_JUKART_Human1.33301043
62* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33075386
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30005596
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26598839
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26592960
66NANOG_19829295_ChIP-Seq_ESCs_Human1.23518170
67SOX2_19829295_ChIP-Seq_ESCs_Human1.23518170
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23243374
69SMAD4_21799915_ChIP-Seq_A2780_Human1.23221338
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.23201856
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.22306339
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21703714
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20478905
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19911424
75* HNF4A_19822575_ChIP-Seq_HepG2_Human1.18859002
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18559662
77* NANOG_18555785_Chip-Seq_ESCs_Mouse1.16999556
78E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16788336
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16460630
80* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16345902
81* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13670207
82FOXA2_19822575_ChIP-Seq_HepG2_Human1.13358560
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13032029
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12486454
85MYC_18555785_ChIP-Seq_MESCs_Mouse1.12305867
86* TCF4_22108803_ChIP-Seq_LS180_Human1.11892232
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.11493190
88ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11183841
89* P53_22387025_ChIP-Seq_ESCs_Mouse1.10352281
90* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10295242
91PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.09731899
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08968897
93* P300_18555785_Chip-Seq_ESCs_Mouse1.08389268
94* STAT3_23295773_ChIP-Seq_U87_Human1.08240953
95FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08230127
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07677579
97AR_25329375_ChIP-Seq_VCAP_Human1.06880343
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06218305
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05151736
100* TCF4_23295773_ChIP-Seq_U87_Human1.03034872
101TP53_22573176_ChIP-Seq_HFKS_Human1.02750644
102FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02341485
103RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01333981
104* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01308231
105* STAT3_18555785_Chip-Seq_ESCs_Mouse1.00963202
106FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00057562
107FOXA1_25329375_ChIP-Seq_VCAP_Human0.99916233
108FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99916233
109* E2F1_18555785_Chip-Seq_ESCs_Mouse0.99018924
110ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98091727
111NANOG_16153702_ChIP-ChIP_HESCs_Human0.98033619
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97920647
113IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96017988
114PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94278542
115KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.93477489
116* AR_20517297_ChIP-Seq_VCAP_Human0.92626642
117RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91149929
118CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89442733
119AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88528482
120RXRA_24833708_ChIP-Seq_LIVER_Mouse0.84103003
121SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79177156
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75383391
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75383391
124KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75149824
125SOX2_27498859_Chip-Seq_STOMACH_Mouse0.73216022
126ESR1_20079471_ChIP-ChIP_T-47D_Human0.72825759
127* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.72691207
128GATA4_25053715_ChIP-Seq_YYC3_Human0.72575476
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.72360405
130* CEBPB_22108803_ChIP-Seq_LS180_Human0.71870812
131Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70347549
132ERG_20517297_ChIP-Seq_VCAP_Human0.69994388
133LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.69889170
134IRF1_19129219_ChIP-ChIP_H3396_Human0.68107365
135PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.64831055
136BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.63047206
137SALL4_18804426_ChIP-ChIP_XEN_Mouse0.62897066
138PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.62759966
139AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.62618968
140BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61906693
141STAT3_1855785_ChIP-Seq_MESCs_Mouse0.61513931
142SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.61119280
143ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.60755986
144PPAR_26484153_Chip-Seq_NCI-H1993_Human0.59476173
145EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.58156908
146BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.58006917
147TAF15_26573619_Chip-Seq_HEK293_Human0.57954721
148TBX20_22080862_ChIP-Seq_HEART_Mouse0.57765264
149TBX20_22328084_ChIP-Seq_HEART_Mouse0.57765264
150GATA4_21415370_ChIP-Seq_HL-1_Mouse0.57713511
151FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.57383408
152TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.56445163
153FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.54197180
154RAD21_21589869_ChIP-Seq_MESCs_Mouse0.53640940
155SCL_19346495_ChIP-Seq_HPC-7_Human0.53182595
156THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.53108293
157NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.51671243
158CBP_21632823_ChIP-Seq_H3396_Human0.51028335
159ZNF263_19887448_ChIP-Seq_K562_Human0.50884045
160JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.50830419
161NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.50424378
162* STAT1_17558387_ChIP-Seq_HELA_Human0.49506256
163TAF2_19829295_ChIP-Seq_ESCs_Human0.49370026
164* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.49293178
165EGR1_19032775_ChIP-ChIP_M12_Human0.47200941
166SALL4_22934838_ChIP-ChIP_CD34+_Human0.46771038
167* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.46416016
168* CRX_20693478_ChIP-Seq_RETINA_Mouse0.45689141
169* FOXA1_25552417_ChIP-Seq_VCAP_Human0.45550113
170* BCAT_22108803_ChIP-Seq_LS180_Human0.45378470
171RARA_24833708_ChIP-Seq_LIVER_Mouse0.45033412
172RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.44529944
173GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.44512038
174* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.44125916
175* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.43903327
176PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42624167
177* ESET_19884257_ChIP-Seq_ESCs_Mouse0.42399137
178* NFE2_27457419_Chip-Seq_LIVER_Mouse0.42329823
179* CDX2_22108803_ChIP-Seq_LS180_Human0.42200074
180RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.41585458
181* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.41227912
182FOXH1_21741376_ChIP-Seq_EPCs_Human0.41139476
183SOX2_22085726_ChIP-Seq_NPCs_Mouse0.41135967

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.84628056
2MP0005360_urolithiasis6.33951776
3MP0005365_abnormal_bile_salt5.65750959
4MP0005085_abnormal_gallbladder_physiolo5.39805829
5MP0003806_abnormal_nucleotide_metabolis4.26395811
6MP0008875_abnormal_xenobiotic_pharmacok4.25586715
7MP0010329_abnormal_lipoprotein_level3.52153296
8MP0005670_abnormal_white_adipose3.30419527
9MP0003252_abnormal_bile_duct2.97971404
10MP0005332_abnormal_amino_acid2.89107186
11MP0008058_abnormal_DNA_repair2.83927730
12MP0006292_abnormal_olfactory_placode2.71115442
13MP0010094_abnormal_chromosome_stability2.55754416
14MP0008877_abnormal_DNA_methylation2.55061124
15MP0004130_abnormal_muscle_cell2.45788527
16MP0003195_calcinosis2.41430399
17MP0005083_abnormal_biliary_tract2.36126906
18MP0001666_abnormal_nutrient_absorption2.33873416
19MP0003191_abnormal_cellular_cholesterol2.33766468
20MP0003718_maternal_effect2.32137934
21MP0002118_abnormal_lipid_homeostasis2.31515638
22MP0002938_white_spotting2.22280914
23MP0001529_abnormal_vocalization2.15489603
24MP0002102_abnormal_ear_morphology2.15382039
25MP0009840_abnormal_foam_cell2.14503360
26MP0005666_abnormal_adipose_tissue2.10158001
27MP0002837_dystrophic_cardiac_calcinosis2.08363685
28MP0000609_abnormal_liver_physiology2.08122432
29MP0003693_abnormal_embryo_hatching2.03042816
30MP0003186_abnormal_redox_activity2.02948595
31MP0009697_abnormal_copulation1.98926547
32MP0008057_abnormal_DNA_replication1.96400908
33MP0006072_abnormal_retinal_apoptosis1.96175351
34MP0008789_abnormal_olfactory_epithelium1.93599734
35MP0005319_abnormal_enzyme/_coenzyme1.93153325
36MP0000372_irregular_coat_pigmentation1.90645912
37MP0006036_abnormal_mitochondrial_physio1.89931130
38MP0004019_abnormal_vitamin_homeostasis1.89384001
39MP0001764_abnormal_homeostasis1.88868777
40MP0000569_abnormal_digit_pigmentation1.83628120
41MP0005584_abnormal_enzyme/coenzyme_acti1.79671944
42MP0003941_abnormal_skin_development1.77112625
43MP0001293_anophthalmia1.71503665
44MP0003136_yellow_coat_color1.70232948
45MP0003880_abnormal_central_pattern1.69016233
46MP0003868_abnormal_feces_composition1.66829735
47MP0001984_abnormal_olfaction1.61058281
48MP0005551_abnormal_eye_electrophysiolog1.59855720
49MP0005253_abnormal_eye_physiology1.59794067
50MP0003890_abnormal_embryonic-extraembry1.59599501
51MP0004957_abnormal_blastocyst_morpholog1.58823718
52MP0002971_abnormal_brown_adipose1.58140545
53MP0006054_spinal_hemorrhage1.51852795
54MP0004185_abnormal_adipocyte_glucose1.45756260
55MP0009643_abnormal_urine_homeostasis1.42817880
56MP0000516_abnormal_urinary_system1.42145838
57MP0005367_renal/urinary_system_phenotyp1.42145838
58MP0001661_extended_life_span1.37513222
59MP0002876_abnormal_thyroid_physiology1.36948808
60MP0005535_abnormal_body_temperature1.36345054
61MP0003121_genomic_imprinting1.36072340
62MP0003567_abnormal_fetal_cardiomyocyte1.33126405
63MP0001485_abnormal_pinna_reflex1.31925795
64MP0002736_abnormal_nociception_after1.29991325
65MP0003646_muscle_fatigue1.29514273
66MP0008932_abnormal_embryonic_tissue1.29179216
67MP0005075_abnormal_melanosome_morpholog1.29017435
68MP0003077_abnormal_cell_cycle1.27564473
69MP0005334_abnormal_fat_pad1.26995100
70MP0003111_abnormal_nucleus_morphology1.24535300
71MP0003656_abnormal_erythrocyte_physiolo1.20864865
72MP0003011_delayed_dark_adaptation1.20274858
73MP0003787_abnormal_imprinting1.18591731
74MP0005499_abnormal_olfactory_system1.17824884
75MP0005394_taste/olfaction_phenotype1.17824884
76MP0005451_abnormal_body_composition1.16578759
77MP0005375_adipose_tissue_phenotype1.15356868
78MP0006035_abnormal_mitochondrial_morpho1.14374356
79MP0003122_maternal_imprinting1.14053560
80MP0002078_abnormal_glucose_homeostasis1.11836065
81MP0005395_other_phenotype1.11108424
82MP0002233_abnormal_nose_morphology1.10058414
83MP0002638_abnormal_pupillary_reflex1.10034429
84MP0002138_abnormal_hepatobiliary_system1.09779092
85MP0002090_abnormal_vision1.09054620
86MP0000647_abnormal_sebaceous_gland1.08670964
87MP0000598_abnormal_liver_morphology1.07358944
88MP0005171_absent_coat_pigmentation1.06966529
89MP0005647_abnormal_sex_gland1.05684480
90MP0003724_increased_susceptibility_to1.05157137
91MP0004147_increased_porphyrin_level1.04714566
92MP0003786_premature_aging1.04084964
93MP0000427_abnormal_hair_cycle1.02309480
94MP0000631_abnormal_neuroendocrine_gland1.02089370
95MP0009763_increased_sensitivity_to1.01278631
96MP0006276_abnormal_autonomic_nervous0.98594894
97MP0002095_abnormal_skin_pigmentation0.98099179
98MP0009764_decreased_sensitivity_to0.97811134
99MP0005330_cardiomyopathy0.97259130
100MP0005174_abnormal_tail_pigmentation0.97111760
101MP0001324_abnormal_eye_pigmentation0.97065482
102MP0001929_abnormal_gametogenesis0.95877633
103MP0009115_abnormal_fat_cell0.95856682
104MP0005266_abnormal_metabolism0.95496859
105MP0005084_abnormal_gallbladder_morpholo0.94752189
106MP0003937_abnormal_limbs/digits/tail_de0.92772680
107MP0005376_homeostasis/metabolism_phenot0.91571559
108MP0005636_abnormal_mineral_homeostasis0.91482347
109MP0002970_abnormal_white_adipose0.91188411
110MP0001486_abnormal_startle_reflex0.90159788
111MP0002751_abnormal_autonomic_nervous0.89354050
112MP0004133_heterotaxia0.89321995
113MP0004142_abnormal_muscle_tone0.88936389
114MP0009642_abnormal_blood_homeostasis0.87355341
115MP0002234_abnormal_pharynx_morphology0.86581662
116MP0008469_abnormal_protein_level0.86041746
117MP0005448_abnormal_energy_balance0.84695373
118MP0000653_abnormal_sex_gland0.84402812
119MP0005379_endocrine/exocrine_gland_phen0.83478541
120MP0002282_abnormal_trachea_morphology0.82901473
121MP0005248_abnormal_Harderian_gland0.82014613
122MP0000383_abnormal_hair_follicle0.81822465
123MP0001756_abnormal_urination0.81751296
124MP0001286_abnormal_eye_development0.81234306
125MP0008007_abnormal_cellular_replicative0.81086920
126MP0005391_vision/eye_phenotype0.79509438
127MP0003690_abnormal_glial_cell0.78903801
128MP0003698_abnormal_male_reproductive0.78558236
129MP0002210_abnormal_sex_determination0.78351539
130MP0001853_heart_inflammation0.77647509
131MP0010368_abnormal_lymphatic_system0.76744861
132MP0005410_abnormal_fertilization0.76247151
133MP0005646_abnormal_pituitary_gland0.75238987
134MP0005645_abnormal_hypothalamus_physiol0.74760283
135MP0009046_muscle_twitch0.74726510
136MP0008775_abnormal_heart_ventricle0.74229906
137MP0009765_abnormal_xenobiotic_induced0.72905389
138MP0000230_abnormal_systemic_arterial0.71740372
139MP0003221_abnormal_cardiomyocyte_apopto0.71530594
140MP0004215_abnormal_myocardial_fiber0.68200081
141MP0004043_abnormal_pH_regulation0.67800924
142MP0005408_hypopigmentation0.67277210
143MP0001544_abnormal_cardiovascular_syste0.67190533
144MP0005385_cardiovascular_system_phenoty0.67190533
145MP0003953_abnormal_hormone_level0.63445800
146MP0008438_abnormal_cutaneous_collagen0.62913029
147MP0006138_congestive_heart_failure0.61197245
148MP0005220_abnormal_exocrine_pancreas0.61140056
149MP0003959_abnormal_lean_body0.60592619
150MP0004036_abnormal_muscle_relaxation0.59886806
151MP0004782_abnormal_surfactant_physiolog0.58725462
152MP0002254_reproductive_system_inflammat0.57582150
153MP0005452_abnormal_adipose_tissue0.56994801
154MP0003705_abnormal_hypodermis_morpholog0.54049977
155MP0002332_abnormal_exercise_endurance0.52841451
156MP0002972_abnormal_cardiac_muscle0.52468603
157MP0002269_muscular_atrophy0.50392333
158MP0002136_abnormal_kidney_physiology0.48877416
159MP0005620_abnormal_muscle_contractility0.48677073
160MP0000343_altered_response_to0.47854106
161MP0004084_abnormal_cardiac_muscle0.47735812
162MP0000749_muscle_degeneration0.47224664
163MP0001881_abnormal_mammary_gland0.45737707
164MP0004087_abnormal_muscle_fiber0.44571782
165MP0000604_amyloidosis0.43372230
166MP0000003_abnormal_adipose_tissue0.39950842
167MP0002132_abnormal_respiratory_system0.39691479
168MP0002060_abnormal_skin_morphology0.39545136
169MP0010630_abnormal_cardiac_muscle0.39324880
170MP0008872_abnormal_physiological_respon0.37220219
171MP0000013_abnormal_adipose_tissue0.35423368
172MP0005595_abnormal_vascular_smooth0.34987017

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.84927355
2Intrahepatic cholestasis (HP:0001406)5.33415922
3Hyperglycinuria (HP:0003108)5.30190459
4Hypoglycemic coma (HP:0001325)5.00164558
5Abnormality of fatty-acid metabolism (HP:0004359)4.95719981
6Abnormality of glycine metabolism (HP:0010895)4.93217457
7Abnormality of serine family amino acid metabolism (HP:0010894)4.93217457
8Hyperammonemia (HP:0001987)4.92920409
9Deep venous thrombosis (HP:0002625)4.92309096
10Xanthomatosis (HP:0000991)4.91433374
11Prolonged partial thromboplastin time (HP:0003645)4.76590858
12Hyperlipoproteinemia (HP:0010980)4.75850769
13Abnormality of monocarboxylic acid metabolism (HP:0010996)4.64247259
14Hyperglycinemia (HP:0002154)4.62330112
15Ketosis (HP:0001946)4.56821715
16Hypobetalipoproteinemia (HP:0003563)4.47698103
17Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.33806968
18Dicarboxylic aciduria (HP:0003215)4.29198831
19Abnormality of dicarboxylic acid metabolism (HP:0010995)4.29198831
20Complement deficiency (HP:0004431)4.25777177
21Hypolipoproteinemia (HP:0010981)3.91420230
22Ketoacidosis (HP:0001993)3.90814599
23Hypoalphalipoproteinemia (HP:0003233)3.86613325
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.81263271
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.73769794
26Epidermoid cyst (HP:0200040)3.73654996
27Generalized aminoaciduria (HP:0002909)3.63752250
28Abnormality of methionine metabolism (HP:0010901)3.62138327
29Abnormality of serum amino acid levels (HP:0003112)3.60018808
30Cerebral edema (HP:0002181)3.58428918
31Abnormality of glutamine family amino acid metabolism (HP:0010902)3.54242192
32Joint hemorrhage (HP:0005261)3.40690225
33Lethargy (HP:0001254)3.38126604
34Abnormality of sulfur amino acid metabolism (HP:0004339)3.35309081
35True hermaphroditism (HP:0010459)3.31156944
36Hepatic necrosis (HP:0002605)3.26051423
37Fat malabsorption (HP:0002630)3.24408478
38Metabolic acidosis (HP:0001942)3.20884356
39Colon cancer (HP:0003003)3.20124703
40Renal cortical cysts (HP:0000803)3.16840470
41Pancreatic cysts (HP:0001737)3.16511268
42Abnormality of the common coagulation pathway (HP:0010990)3.13280856
43Mitochondrial inheritance (HP:0001427)3.05860172
44Abnormality of the intrinsic pathway (HP:0010989)3.05760399
45Myoglobinuria (HP:0002913)3.01743504
46Medial flaring of the eyebrow (HP:0010747)2.99942204
47Abnormality of complement system (HP:0005339)2.98768990
48Pancreatic fibrosis (HP:0100732)2.97255286
49Hypercholesterolemia (HP:0003124)2.96256257
50Nausea (HP:0002018)2.93503101
51Abnormality of the labia minora (HP:0012880)2.86811759
52Increased hepatocellular lipid droplets (HP:0006565)2.86737447
53Proximal tubulopathy (HP:0000114)2.86086360
54Acute encephalopathy (HP:0006846)2.84513211
55Hyperbilirubinemia (HP:0002904)2.82692808
56Delayed CNS myelination (HP:0002188)2.79524877
57Abnormality of pyrimidine metabolism (HP:0004353)2.75634364
58Vomiting (HP:0002013)2.73921223
59Rhabdomyolysis (HP:0003201)2.72918362
60Molar tooth sign on MRI (HP:0002419)2.72158086
61Abnormality of midbrain morphology (HP:0002418)2.72158086
62Conjugated hyperbilirubinemia (HP:0002908)2.70819513
63Abnormality of nucleobase metabolism (HP:0010932)2.70125054
64Increased muscle lipid content (HP:0009058)2.68460106
65Abnormality of purine metabolism (HP:0004352)2.67370399
66Steatorrhea (HP:0002570)2.63900388
67Methylmalonic aciduria (HP:0012120)2.62773393
68Congenital primary aphakia (HP:0007707)2.59030855
69Intestinal atresia (HP:0011100)2.57586462
70Hypertriglyceridemia (HP:0002155)2.56820017
71Nephronophthisis (HP:0000090)2.56728252
72Hypoglycemic seizures (HP:0002173)2.52943145
73Gait imbalance (HP:0002141)2.48547184
74Pancreatitis (HP:0001733)2.44914530
75Abnormality of glycolysis (HP:0004366)2.44115203
76Increased serum pyruvate (HP:0003542)2.44115203
77Nephrogenic diabetes insipidus (HP:0009806)2.40877341
78Skin nodule (HP:0200036)2.31975949
79Lactic acidosis (HP:0003128)2.31642272
80Methylmalonic acidemia (HP:0002912)2.31469748
81Hepatocellular necrosis (HP:0001404)2.30413266
82Abnormality of chromosome stability (HP:0003220)2.29695918
83Brushfield spots (HP:0001088)2.28173357
84Genital tract atresia (HP:0001827)2.27992086
85Myocardial infarction (HP:0001658)2.27384756
86Volvulus (HP:0002580)2.26695053
87Abnormality of proline metabolism (HP:0010907)2.26309773
88Hydroxyprolinuria (HP:0003080)2.26309773
89Abnormality of urine glucose concentration (HP:0011016)2.25661443
90Glycosuria (HP:0003076)2.25661443
91Abnormality of vitamin B metabolism (HP:0004340)2.24565127
92Hypothermia (HP:0002045)2.24419366
93Aplasia/Hypoplasia of the uvula (HP:0010293)2.22239715
94Vaginal atresia (HP:0000148)2.21667383
95Meckel diverticulum (HP:0002245)2.20735640
96Degeneration of anterior horn cells (HP:0002398)2.19902739
97Abnormality of the anterior horn cell (HP:0006802)2.19902739
98Abnormal mitochondria in muscle tissue (HP:0008316)2.19380624
99Hyperinsulinemic hypoglycemia (HP:0000825)2.17893901
100Abnormality of the renal medulla (HP:0100957)2.17560020
101Renal Fanconi syndrome (HP:0001994)2.17022017
102Abnormality of the vitamin B12 metabolism (HP:0004341)2.16643809
103Elevated hepatic transaminases (HP:0002910)2.16519849
104Acute hepatic failure (HP:0006554)2.15630348
105Gout (HP:0001997)2.15262243
106Hepatocellular carcinoma (HP:0001402)2.14918418
107Abnormality of the ileum (HP:0001549)2.14429176
108Acute necrotizing encephalopathy (HP:0006965)2.12345962
1093-Methylglutaconic aciduria (HP:0003535)2.11586562
110Aplasia/Hypoplasia of the tongue (HP:0010295)2.11247134
111Pancreatic islet-cell hyperplasia (HP:0004510)2.10371199
112Increased serum lactate (HP:0002151)2.10055363
113Oligomenorrhea (HP:0000876)2.09574007
114Tubulointerstitial nephritis (HP:0001970)2.07790921
115Abnormality of the renal cortex (HP:0011035)2.04269450
116Abolished electroretinogram (ERG) (HP:0000550)2.03489947
117Abnormal lung lobation (HP:0002101)2.03260095
118Opisthotonus (HP:0002179)2.02813445
119Abnormality of alanine metabolism (HP:0010916)2.02664771
120Hyperalaninemia (HP:0003348)2.02664771
121Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02664771
122Hyperglycemia (HP:0003074)2.02049193
123Hyperuricemia (HP:0002149)1.99418228
124Increased purine levels (HP:0004368)1.99418228
125Abnormal gallbladder morphology (HP:0012437)1.98935925
126Cholelithiasis (HP:0001081)1.97485794
127Increased CSF lactate (HP:0002490)1.96232409
128Type I transferrin isoform profile (HP:0003642)1.95258221
129Irritability (HP:0000737)1.94647947
130Respiratory distress (HP:0002098)1.94471768
131Postaxial foot polydactyly (HP:0001830)1.93783220
132Lipid accumulation in hepatocytes (HP:0006561)1.93589898
133Abnormal cartilage morphology (HP:0002763)1.92548995
134Enlarged kidneys (HP:0000105)1.92455545
135Sensorimotor neuropathy (HP:0007141)1.91014855
136Vascular calcification (HP:0004934)1.90895470
137Supernumerary spleens (HP:0009799)1.90433068
138Bile duct proliferation (HP:0001408)1.90103299
139Abnormal biliary tract physiology (HP:0012439)1.90103299
140Male pseudohermaphroditism (HP:0000037)1.89326417
141Respiratory failure (HP:0002878)1.89154033
142Progressive macrocephaly (HP:0004481)1.87950623
143Spontaneous abortion (HP:0005268)1.86348469
144Late onset (HP:0003584)1.85932386
145Neoplasm of the adrenal gland (HP:0100631)1.85712797
146Aplasia/Hypoplasia of the tibia (HP:0005772)1.85108559
147Abnormality of the duodenum (HP:0002246)1.85001137
148Median cleft lip (HP:0000161)1.84845212
149Poor coordination (HP:0002370)1.84743841
150Sloping forehead (HP:0000340)1.82979853
151Postaxial hand polydactyly (HP:0001162)1.80530099
152Chromsome breakage (HP:0040012)1.78428784
153Chronic hepatic failure (HP:0100626)1.77710958
154Cystic liver disease (HP:0006706)1.77574487
155Congenital hepatic fibrosis (HP:0002612)1.77226185
156Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77019830
157Abnormal protein N-linked glycosylation (HP:0012347)1.77019830
158Abnormal protein glycosylation (HP:0012346)1.77019830
159Abnormal glycosylation (HP:0012345)1.77019830
160CNS demyelination (HP:0007305)1.76707572
161Leukodystrophy (HP:0002415)1.75844741
162Oculomotor apraxia (HP:0000657)1.74754702
163Sclerocornea (HP:0000647)1.72926088
164Septo-optic dysplasia (HP:0100842)1.72722607
165Anencephaly (HP:0002323)1.72410619
166Bifid tongue (HP:0010297)1.69253783
167Abnormality of the preputium (HP:0100587)1.68502966
168Small intestinal stenosis (HP:0012848)1.68235638

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.67099691
2INSRR3.23651305
3SIK13.18153385
4PDK33.07114561
5PDK43.07114561
6WNK32.96770136
7TRIM282.87278439
8ERN12.50371462
9MAP4K22.49820436
10MST42.48464303
11TNIK2.46682814
12FGFR42.41881885
13TIE12.31080034
14NEK12.24784616
15FLT32.21578696
16FRK2.20259549
17VRK22.16633233
18BUB12.12066020
19MKNK22.08381631
20TRIB32.07990148
21BCR2.02739284
22PINK11.99464702
23PDK21.98493579
24NEK91.97384671
25MKNK11.96184128
26PBK1.94664235
27PIK3CG1.92880942
28PLK31.88579762
29CAMK1D1.85108370
30SRPK11.84859053
31OBSCN1.73564781
32TTK1.69850373
33PKN21.68544196
34WEE11.65967914
35PRKAA21.60810216
36PLK41.54567845
37VRK11.53766147
38TAOK31.53236283
39MAPK131.52322002
40IRAK31.46950996
41CDC71.46302403
42PIK3CA1.46277609
43TEC1.45198536
44NME21.43837204
45STK38L1.40685898
46MAPK111.38489559
47PLK21.33272689
48TSSK61.31781908
49FGFR21.31022167
50MYLK1.30808155
51PNCK1.26832937
52STK161.20840761
53CSNK1G11.18750170
54PLK11.17027099
55OXSR11.15972511
56ERBB31.12503564
57CCNB11.11938107
58STK391.08230635
59ZAK1.07237159
60MAP3K41.05601312
61MAP3K121.05543915
62MST1R1.05049264
63ABL21.00296412
64ERBB40.99623537
65TAOK20.98411550
66CASK0.97922786
67ACVR1B0.94224436
68CSNK1G30.93982338
69TYK20.93823484
70MAP2K30.92131667
71CSNK1G20.91957700
72KDR0.91109388
73EIF2AK30.90463270
74PHKG10.85526052
75PHKG20.85526052
76LMTK20.83883488
77BMPR1B0.83653859
78PRKAA10.82015810
79FGFR30.81781811
80MAP2K40.80246954
81TAF10.79631865
82NME10.79548604
83MAPK40.79293337
84CSNK1A1L0.77712007
85JAK10.77295374
86EPHA40.76534478
87MAPK120.75532474
88STK30.74698801
89MAP3K140.74141069
90CAMK1G0.73897936
91JAK20.72946827
92ATR0.69255401
93TGFBR20.68880095
94PRKCE0.67956371
95SGK20.67407974
96PRKACG0.66796591
97MAP3K70.65478047
98SGK30.65442173
99MAP3K30.65415816
100DYRK20.64387833
101EIF2AK20.63117899
102CDK90.63058462
103TTN0.62965305
104ATM0.62754020
105PAK30.62449813
106STK240.58227506
107TRPM70.57064101
108IGF1R0.56886054
109AURKB0.56097700
110MAP2K60.55994155
111FER0.53901349
112TBK10.53746985
113CDK80.53368742
114PRKCG0.52800271
115AKT30.52349115
116IRAK10.51737712
117GRK70.51692463
118RPS6KB10.51475409
119TNK20.50544405
120EIF2AK10.50394942
121CDK60.49761615
122PRKD30.49176115
123KIT0.49073309
124IRAK40.47176038
125CAMK2G0.46207995
126MINK10.45935268
127MAP2K70.45520865
128CSF1R0.45508930
129PDPK10.45499868
130PKN10.45051979
131TGFBR10.42141321
132CSNK1A10.41463405
133MAPK70.41007521
134FGFR10.40515417
135SGK2230.39912337
136SGK4940.39912337
137NUAK10.39535150
138CSNK2A10.39236311
139ADRBK20.38826363
140CHEK20.38594062
141MAP3K50.37908055
142BRSK10.37433472
143DYRK30.36391629
144IRAK20.36348539
145GSK3A0.35378694
146EPHA30.35339800
147CSNK2A20.35039648
148PDK10.34698593
149CHEK10.34321091
150CDK30.33600366
151MAP2K10.33264053
152CAMK2A0.32103914
153ADRBK10.32071231
154PRKACA0.31937104
155BRSK20.31866096
156CDK40.31782380
157MAPKAPK50.31717192
158GRK10.31651196
159PASK0.31431760
160BTK0.30455865
161PRKACB0.30302815
162WNK40.30075364
163PRKDC0.30053407
164PRKCQ0.29884218
165MUSK0.29808090
166CSNK1E0.29713423
167LATS10.29541990
168NLK0.28243237
169PTK60.28093869

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.51244208
2* Propanoate metabolism_Homo sapiens_hsa006403.27262189
3* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.19924907
4Fatty acid degradation_Homo sapiens_hsa000713.18929925
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.83143510
6Fatty acid metabolism_Homo sapiens_hsa012122.59420252
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55347362
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.53767077
9Nitrogen metabolism_Homo sapiens_hsa009102.52813586
10Tryptophan metabolism_Homo sapiens_hsa003802.50976719
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.41902403
12Non-homologous end-joining_Homo sapiens_hsa034502.38606746
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.36793970
14PPAR signaling pathway_Homo sapiens_hsa033202.36482603
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.35496286
16Peroxisome_Homo sapiens_hsa041462.33038397
17Arginine biosynthesis_Homo sapiens_hsa002202.24547065
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.23285581
19Butanoate metabolism_Homo sapiens_hsa006502.21682640
20Mismatch repair_Homo sapiens_hsa034302.19551315
21Homologous recombination_Homo sapiens_hsa034402.05351000
22Caffeine metabolism_Homo sapiens_hsa002321.99823885
23Complement and coagulation cascades_Homo sapiens_hsa046101.97448957
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.97176864
25Pyruvate metabolism_Homo sapiens_hsa006201.95990791
26Fatty acid elongation_Homo sapiens_hsa000621.95956164
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92053067
28* beta-Alanine metabolism_Homo sapiens_hsa004101.90561685
29RNA polymerase_Homo sapiens_hsa030201.89125098
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.86650328
31Fanconi anemia pathway_Homo sapiens_hsa034601.76883714
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70455945
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70155106
34* Carbon metabolism_Homo sapiens_hsa012001.69713649
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67385391
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.67269245
37Chemical carcinogenesis_Homo sapiens_hsa052041.66642357
38Basal transcription factors_Homo sapiens_hsa030221.60038814
39Histidine metabolism_Homo sapiens_hsa003401.57257612
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.56930218
41Sulfur metabolism_Homo sapiens_hsa009201.56337972
42DNA replication_Homo sapiens_hsa030301.55450568
43Phenylalanine metabolism_Homo sapiens_hsa003601.50647619
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.46511944
45Retinol metabolism_Homo sapiens_hsa008301.39174909
46RNA degradation_Homo sapiens_hsa030181.36971190
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36597208
48Tyrosine metabolism_Homo sapiens_hsa003501.35598141
49Folate biosynthesis_Homo sapiens_hsa007901.34587020
50Starch and sucrose metabolism_Homo sapiens_hsa005001.32630913
51Nucleotide excision repair_Homo sapiens_hsa034201.29527766
52Selenocompound metabolism_Homo sapiens_hsa004501.26831338
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25437197
54Fatty acid biosynthesis_Homo sapiens_hsa000611.23318163
55Biosynthesis of amino acids_Homo sapiens_hsa012301.21899765
56Staphylococcus aureus infection_Homo sapiens_hsa051501.20425103
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.16122349
58Fat digestion and absorption_Homo sapiens_hsa049751.15392325
59Vitamin B6 metabolism_Homo sapiens_hsa007501.04862037
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04033400
61Base excision repair_Homo sapiens_hsa034101.02717767
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02374416
63Phototransduction_Homo sapiens_hsa047441.00402013
64Glycerolipid metabolism_Homo sapiens_hsa005611.00211941
65RNA transport_Homo sapiens_hsa030130.98495185
66Arginine and proline metabolism_Homo sapiens_hsa003300.94181016
67ABC transporters_Homo sapiens_hsa020100.94135316
68Bile secretion_Homo sapiens_hsa049760.91787041
69Sulfur relay system_Homo sapiens_hsa041220.90231026
70Steroid biosynthesis_Homo sapiens_hsa001000.87401718
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85579439
72Ribosome_Homo sapiens_hsa030100.85021765
73Spliceosome_Homo sapiens_hsa030400.84971684
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83898534
75Vitamin digestion and absorption_Homo sapiens_hsa049770.82343004
76Glutathione metabolism_Homo sapiens_hsa004800.80272642
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78607423
78Pentose phosphate pathway_Homo sapiens_hsa000300.75475950
79Lysine degradation_Homo sapiens_hsa003100.74307229
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73138407
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70066483
82Cell cycle_Homo sapiens_hsa041100.67148784
83* Metabolic pathways_Homo sapiens_hsa011000.65773167
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.62199266
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.61960267
86One carbon pool by folate_Homo sapiens_hsa006700.58846475
87Oxidative phosphorylation_Homo sapiens_hsa001900.58602832
88Oocyte meiosis_Homo sapiens_hsa041140.57206696
89Ether lipid metabolism_Homo sapiens_hsa005650.54166119
90Parkinsons disease_Homo sapiens_hsa050120.53820725
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.49545867
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41000202
93p53 signaling pathway_Homo sapiens_hsa041150.40019923
94Fructose and mannose metabolism_Homo sapiens_hsa000510.38203248
95Galactose metabolism_Homo sapiens_hsa000520.37740998
96Circadian rhythm_Homo sapiens_hsa047100.35652892
97Insulin resistance_Homo sapiens_hsa049310.34578068
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33459690
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32436954
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30703718
101Alzheimers disease_Homo sapiens_hsa050100.28306452
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26301070
103AMPK signaling pathway_Homo sapiens_hsa041520.23839102
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.21502432
105Linoleic acid metabolism_Homo sapiens_hsa005910.19968743
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.19736549
107Huntingtons disease_Homo sapiens_hsa050160.18591259
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17940509
109Glucagon signaling pathway_Homo sapiens_hsa049220.17670421
110Arachidonic acid metabolism_Homo sapiens_hsa005900.11017793
111Protein export_Homo sapiens_hsa030600.08090799
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.04815476
113Regulation of autophagy_Homo sapiens_hsa041400.04015028
114Insulin signaling pathway_Homo sapiens_hsa049100.03378369
115Pyrimidine metabolism_Homo sapiens_hsa002400.00398396
116Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1918835
117Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.1888408
118Protein digestion and absorption_Homo sapiens_hsa04974-0.1798904
119Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1715112
120Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1481308
121Proteasome_Homo sapiens_hsa03050-0.1398484
122Purine metabolism_Homo sapiens_hsa00230-0.1364618
123Renin-angiotensin system_Homo sapiens_hsa04614-0.0996740
124Cardiac muscle contraction_Homo sapiens_hsa04260-0.0935831
125Prion diseases_Homo sapiens_hsa05020-0.0549472

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »