HIF1AN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)6.19965875
2muscle filament sliding (GO:0030049)6.14956821
3actin-myosin filament sliding (GO:0033275)6.14956821
4regulation of skeletal muscle contraction (GO:0014819)5.50872070
5sarcomere organization (GO:0045214)5.49916642
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.33264417
7carnitine shuttle (GO:0006853)5.13361361
8actin-mediated cell contraction (GO:0070252)4.95719991
9negative regulation of potassium ion transmembrane transport (GO:1901380)4.80087553
10sarcoplasmic reticulum calcium ion transport (GO:0070296)4.70897095
11myofibril assembly (GO:0030239)4.67472667
12cardiac myofibril assembly (GO:0055003)4.66205284
13fatty acid transmembrane transport (GO:1902001)4.54168800
14positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.48685533
15skeletal muscle contraction (GO:0003009)4.47274539
16histone H3-K36 demethylation (GO:0070544)4.38150186
17skeletal muscle adaptation (GO:0043501)4.25152217
18regulation of necroptotic process (GO:0060544)4.22397787
19actin filament-based movement (GO:0030048)4.18180683
20negative regulation of cell size (GO:0045792)4.10539847
21negative regulation of necroptotic process (GO:0060546)4.04908088
22striated muscle contraction (GO:0006941)3.97929995
23actomyosin structure organization (GO:0031032)3.94697326
242-oxoglutarate metabolic process (GO:0006103)3.90951767
25tricarboxylic acid cycle (GO:0006099)3.90056363
263-UTR-mediated mRNA stabilization (GO:0070935)3.85116949
27lysine catabolic process (GO:0006554)3.85073097
28lysine metabolic process (GO:0006553)3.85073097
29cardiac muscle contraction (GO:0060048)3.79277691
30carnitine transmembrane transport (GO:1902603)3.79067564
31regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.75982419
32positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.70035651
33regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.64964364
34peptidyl-lysine dimethylation (GO:0018027)3.61268683
35amino-acid betaine transport (GO:0015838)3.53962446
36carnitine transport (GO:0015879)3.53962446
37cardiac muscle cell development (GO:0055013)3.50129738
38pre-miRNA processing (GO:0031054)3.34514715
39regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.32672513
40regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.30912309
41cardiac cell development (GO:0055006)3.28343877
42nuclear pore complex assembly (GO:0051292)3.28277675
43muscle atrophy (GO:0014889)3.27953111
44creatine metabolic process (GO:0006600)3.27125167
45glycogen catabolic process (GO:0005980)3.26558377
46striated muscle adaptation (GO:0014888)3.24398338
47regulation of acyl-CoA biosynthetic process (GO:0050812)3.23364387
48regulation of histone H3-K27 methylation (GO:0061085)3.22019062
49negative regulation of cell killing (GO:0031342)3.19889391
50negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.19889391
51SMAD protein complex assembly (GO:0007183)3.15206260
52regulation of cofactor metabolic process (GO:0051193)3.12639100
53regulation of coenzyme metabolic process (GO:0051196)3.12639100
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.11466614
55striated muscle atrophy (GO:0014891)3.09648550
56glucan catabolic process (GO:0009251)3.09163663
57positive regulation of fatty acid beta-oxidation (GO:0032000)3.08069545
58response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.07636920
59regulation of fatty acid beta-oxidation (GO:0031998)3.07464952
60muscle contraction (GO:0006936)3.05742988
61ventricular cardiac muscle cell action potential (GO:0086005)3.02357822
62cardiac muscle hypertrophy (GO:0003300)3.00436975
63regulation of RNA export from nucleus (GO:0046831)3.00302617
64NLS-bearing protein import into nucleus (GO:0006607)2.97459658
65regulation of fatty acid oxidation (GO:0046320)2.97391449
66aspartate family amino acid catabolic process (GO:0009068)2.96533566
67striated muscle hypertrophy (GO:0014897)2.94000542
68regulation of gamma-delta T cell differentiation (GO:0045586)2.93524176
69focal adhesion assembly (GO:0048041)2.93264747
70cell-substrate adherens junction assembly (GO:0007045)2.93264747
71adherens junction assembly (GO:0034333)2.91053924
72positive regulation of myotube differentiation (GO:0010831)2.90319250
73NADH metabolic process (GO:0006734)2.89886270
74cellular response to virus (GO:0098586)2.89287557
75cell communication by electrical coupling (GO:0010644)2.88044088
76tricarboxylic acid metabolic process (GO:0072350)2.87340535
77regulation of relaxation of muscle (GO:1901077)2.87163353
78skeletal muscle fiber development (GO:0048741)2.86726327
79cellular polysaccharide catabolic process (GO:0044247)2.86643741
80regulation of NFAT protein import into nucleus (GO:0051532)2.86048814
81negative regulation of viral release from host cell (GO:1902187)2.85119521
82positive regulation of glycogen biosynthetic process (GO:0045725)2.84216419
83oxaloacetate metabolic process (GO:0006107)2.83357353
84negative regulation of necrotic cell death (GO:0060547)2.83159843
85regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.82004240
86nuclear pore organization (GO:0006999)2.80508321
87intracellular lipid transport (GO:0032365)2.77374085
88cellular hyperosmotic response (GO:0071474)2.76815651
89cell communication involved in cardiac conduction (GO:0086065)2.76737765
90fatty acid homeostasis (GO:0055089)2.75160217
91muscle system process (GO:0003012)2.75050050
92glycogen metabolic process (GO:0005977)2.73664097
93negative regulation of cardiac muscle tissue growth (GO:0055022)2.73355870
94negative regulation of heart growth (GO:0061117)2.73355870
95regulation of translational termination (GO:0006449)2.73321907
96negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.72604527
97negative regulation of translation, ncRNA-mediated (GO:0040033)2.72604527
98regulation of translation, ncRNA-mediated (GO:0045974)2.72604527
99regulation of p38MAPK cascade (GO:1900744)2.71505414
100cardiac muscle hypertrophy in response to stress (GO:0014898)2.71004101
101muscle hypertrophy in response to stress (GO:0003299)2.71004101
102cardiac muscle adaptation (GO:0014887)2.71004101
103polysaccharide catabolic process (GO:0000272)2.70162394
1044-hydroxyproline metabolic process (GO:0019471)2.69767355
105cellular glucan metabolic process (GO:0006073)2.69328100
106glucan metabolic process (GO:0044042)2.69328100
107interkinetic nuclear migration (GO:0022027)2.69072993
108mRNA stabilization (GO:0048255)2.67279807
109RNA stabilization (GO:0043489)2.67279807
110pyrimidine ribonucleoside catabolic process (GO:0046133)2.66669315
111macroautophagy (GO:0016236)2.65881669
112positive regulation of histone deacetylation (GO:0031065)2.64097433
113regulation of gamma-delta T cell activation (GO:0046643)2.62624463
114muscle fiber development (GO:0048747)2.62577677
115histone lysine demethylation (GO:0070076)2.61748405
116striated muscle cell development (GO:0055002)2.61559846
117mannose metabolic process (GO:0006013)2.61141371
118valine metabolic process (GO:0006573)2.60685333
119histone H3-K9 demethylation (GO:0033169)2.60262436
120regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.59558097
121regulation of sulfur metabolic process (GO:0042762)2.59491165
122regulation of cholesterol homeostasis (GO:2000188)2.58879969
123cytoplasmic mRNA processing body assembly (GO:0033962)2.58850653
124insulin-like growth factor receptor signaling pathway (GO:0048009)2.56923947
125glycogen biosynthetic process (GO:0005978)2.56898455
126glucan biosynthetic process (GO:0009250)2.56898455
127glycolytic process (GO:0006096)2.55261856
128cell-substrate junction assembly (GO:0007044)2.54797066
129dicarboxylic acid biosynthetic process (GO:0043650)2.54710620
130regulation of posttranscriptional gene silencing (GO:0060147)2.54541233
131regulation of gene silencing by miRNA (GO:0060964)2.54541233
132regulation of gene silencing by RNA (GO:0060966)2.54541233
133positive regulation of protein import into nucleus, translocation (GO:0033160)2.53617869
134regulation of hippo signaling (GO:0035330)2.50610322
135histone demethylation (GO:0016577)2.50448146
136regulation of necrotic cell death (GO:0010939)2.50174933
137negative regulation of myotube differentiation (GO:0010832)2.48943415
138phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.48410155
139snRNA processing (GO:0016180)2.45103331
140* regulation of myotube differentiation (GO:0010830)2.44516455
141positive regulation of gamma-delta T cell activation (GO:0046645)2.44465735
142regulation of nucleobase-containing compound transport (GO:0032239)2.44294013
143snRNA metabolic process (GO:0016073)2.42312757
144necroptotic process (GO:0070266)2.42163745
145negative thymic T cell selection (GO:0045060)2.40709229
146myoblast fusion (GO:0007520)2.38987527
147negative regulation of DNA repair (GO:0045738)2.38931724
148spliceosomal tri-snRNP complex assembly (GO:0000244)2.37679132
149heterochromatin organization (GO:0070828)2.33874806
150syncytium formation by plasma membrane fusion (GO:0000768)2.33199440
151intracellular estrogen receptor signaling pathway (GO:0030520)2.32229973
152hepatocyte apoptotic process (GO:0097284)2.31766112
153embryonic process involved in female pregnancy (GO:0060136)2.31277619
154positive regulation of gene expression, epigenetic (GO:0045815)2.29458863
155negative regulation of erythrocyte differentiation (GO:0045647)2.27771817
156antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.26957933
157regulation of alkaline phosphatase activity (GO:0010692)2.26824616
158adult heart development (GO:0007512)2.25912173
159monoubiquitinated protein deubiquitination (GO:0035520)2.25524673
160histone H4-K16 acetylation (GO:0043984)2.25073163
161peptidyl-threonine dephosphorylation (GO:0035970)2.23778680

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.69489617
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.39781290
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.06175085
4ZNF263_19887448_ChIP-Seq_K562_Human2.87495074
5MYC_22102868_ChIP-Seq_BL_Human2.68830040
6CLOCK_20551151_ChIP-Seq_293T_Human2.53310703
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.49706757
8KDM2B_26808549_Chip-Seq_DND41_Human2.46265732
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.44780820
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.42760105
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.42458074
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.39481891
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.27347794
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.22876916
15TBX20_22080862_ChIP-Seq_HEART_Mouse2.21262124
16TBX20_22328084_ChIP-Seq_HEART_Mouse2.21262124
17ZFP281_18757296_ChIP-ChIP_E14_Mouse2.15696200
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.13750273
19TCF7_22412390_ChIP-Seq_EML_Mouse2.12909187
20KDM2B_26808549_Chip-Seq_SUP-B15_Human2.12860045
21STAT6_21828071_ChIP-Seq_BEAS2B_Human2.12107817
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.05815476
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.01261814
24LXR_22158963_ChIP-Seq_LIVER_Mouse2.00549885
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.00094444
26* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.98045858
27KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.96246812
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95545421
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.93719289
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86745369
31LXR_22292898_ChIP-Seq_THP-1_Human1.86378682
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.77375685
33DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.75517577
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.74409833
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.73889855
36RACK7_27058665_Chip-Seq_MCF-7_Human1.71007515
37* ATF3_27146783_Chip-Seq_COLON_Human1.70637098
38KDM2B_26808549_Chip-Seq_K562_Human1.70393891
39P300_27058665_Chip-Seq_ZR-75-30cells_Human1.69940859
40CREB1_26743006_Chip-Seq_LNCaP_Human1.66444367
41CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.63177575
42MAF_26560356_Chip-Seq_TH2_Human1.61717828
43MYB_26560356_Chip-Seq_TH2_Human1.59446236
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59229040
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.58651659
46KDM2B_26808549_Chip-Seq_JURKAT_Human1.57656714
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56532019
48* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56274851
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55679009
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.55270686
51EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.54317036
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.53937932
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.53733647
54FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.51810624
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.51783338
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.50645258
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49435816
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48818900
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.48809805
60P68_20966046_ChIP-Seq_HELA_Human1.47252070
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47226844
62MYB_26560356_Chip-Seq_TH1_Human1.47157272
63RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46011927
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45347760
65VDR_24763502_ChIP-Seq_THP-1_Human1.44717025
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.44419960
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44098696
68E2F7_22180533_ChIP-Seq_HELA_Human1.44035438
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43818362
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41207337
71ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.40261564
72* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38638530
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33688535
74RUNX_20019798_ChIP-Seq_JUKART_Human1.30081321
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29670964
76SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28779731
77FOXA2_19822575_ChIP-Seq_HepG2_Human1.28196943
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27954163
79PKCTHETA_26484144_Chip-Seq_BREAST_Human1.27428966
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27045733
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26770782
82TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25559630
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24893776
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24779313
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22888545
86NCOR1_26117541_ChIP-Seq_K562_Human1.22693369
87GATA4_21415370_ChIP-Seq_HL-1_Mouse1.22180446
88VDR_21846776_ChIP-Seq_THP-1_Human1.21585372
89UTX_26944678_Chip-Seq_JUKART_Human1.21260610
90MAF_26560356_Chip-Seq_TH1_Human1.20898917
91TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.20536273
92ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20017272
93TFEB_21752829_ChIP-Seq_HELA_Human1.16342039
94SPI1_23127762_ChIP-Seq_K562_Human1.15775617
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14908097
96NOTCH1_21737748_ChIP-Seq_TLL_Human1.13584617
97PU_27001747_Chip-Seq_BMDM_Mouse1.13554000
98GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13501390
99EP300_21415370_ChIP-Seq_HL-1_Mouse1.13293678
100SCL_19346495_ChIP-Seq_HPC-7_Human1.13195741
101CIITA_25753668_ChIP-Seq_RAJI_Human1.12190300
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12040408
103* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11870223
104SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11609712
105CHD1_26751641_Chip-Seq_LNCaP_Human1.10637715
106FOXO3_23340844_ChIP-Seq_DLD1_Human1.10545242
107TP63_22573176_ChIP-Seq_HFKS_Human1.08779457
108GATA1_19941826_ChIP-Seq_K562_Human1.08642333
109GATA6_25053715_ChIP-Seq_YYC3_Human1.08155677
110CTCF_21964334_ChIP-Seq_BJAB-B_Human1.07926952
111RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07482123
112MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07302556
113SMC4_20622854_ChIP-Seq_HELA_Human1.07019235
114STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06844391
115E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06633209
116* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06541584
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04715334
118SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04624652
119SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04624652
120CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04182288
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03925477
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03740901
123GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.02586121
124DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01513964
125GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01167375
126SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01151691
127ISL1_27105846_Chip-Seq_CPCs_Mouse1.01123042
128GATA3_27048872_Chip-Seq_THYMUS_Human1.00964520
129SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00937226
130* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00853923
131DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00246640
132PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99945748
133TP53_22127205_ChIP-Seq_IMR90_Human0.98673830
134GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98181119
135HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.97135844
136CTCF_27219007_Chip-Seq_Bcells_Human0.96621686
137E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96031970
138TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95530453
139SPI1_23547873_ChIP-Seq_NB4_Human0.94379417
140KDM5A_27292631_Chip-Seq_BREAST_Human0.94329819
141UBF1/2_26484160_Chip-Seq_HMECs_Human0.94285195
142ELF1_20517297_ChIP-Seq_JURKAT_Human0.94001506
143CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93485774
144* CTCF_21964334_Chip-Seq_Bcells_Human0.93295886
145ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93019035
146KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92988880
147NANOG_21062744_ChIP-ChIP_HESCs_Human0.90318897

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy4.45252855
2MP0003646_muscle_fatigue4.25887342
3MP0002837_dystrophic_cardiac_calcinosis4.25563079
4MP0004145_abnormal_muscle_electrophysio3.78930747
5MP0000749_muscle_degeneration3.58835429
6MP0005451_abnormal_body_composition3.52937852
7MP0004084_abnormal_cardiac_muscle3.39620853
8MP0004036_abnormal_muscle_relaxation3.34277915
9MP0003705_abnormal_hypodermis_morpholog3.33032728
10MP0004130_abnormal_muscle_cell3.08021479
11MP0004087_abnormal_muscle_fiber2.98744364
12MP0000747_muscle_weakness2.97478389
13MP0002269_muscular_atrophy2.81261101
14MP0002106_abnormal_muscle_physiology2.69239816
15MP0004233_abnormal_muscle_weight2.61837575
16MP0000750_abnormal_muscle_regeneration2.55670584
17MP0001346_abnormal_lacrimal_gland2.50089452
18* MP0000759_abnormal_skeletal_muscle2.41089458
19MP0005330_cardiomyopathy2.31587322
20MP0004215_abnormal_myocardial_fiber2.24804480
21MP0005620_abnormal_muscle_contractility2.22770609
22MP0005369_muscle_phenotype2.14868392
23MP0004185_abnormal_adipocyte_glucose2.05959652
24MP0002009_preneoplasia2.05445197
25MP0008057_abnormal_DNA_replication2.02241953
26MP0010630_abnormal_cardiac_muscle1.98571711
27MP0002254_reproductive_system_inflammat1.95862843
28MP0000733_abnormal_muscle_development1.92263624
29MP0005666_abnormal_adipose_tissue1.88386987
30MP0005076_abnormal_cell_differentiation1.82243726
31MP0002396_abnormal_hematopoietic_system1.73718027
32MP0002972_abnormal_cardiac_muscle1.64260848
33MP0003221_abnormal_cardiomyocyte_apopto1.60862602
34MP0003763_abnormal_thymus_physiology1.59737792
35MP0010352_gastrointestinal_tract_polyps1.51863186
36MP0002234_abnormal_pharynx_morphology1.50699584
37MP0003191_abnormal_cellular_cholesterol1.48787777
38MP0004264_abnormal_extraembryonic_tissu1.47180355
39MP0005375_adipose_tissue_phenotype1.46158614
40MP0005385_cardiovascular_system_phenoty1.44450288
41MP0001544_abnormal_cardiovascular_syste1.44450288
42MP0008775_abnormal_heart_ventricle1.40010409
43MP0008260_abnormal_autophagy1.33196147
44MP0002139_abnormal_hepatobiliary_system1.32419921
45MP0004484_altered_response_of1.30315289
46MP0005187_abnormal_penis_morphology1.29543428
47MP0003137_abnormal_impulse_conducting1.28300791
48MP0003950_abnormal_plasma_membrane1.25904538
49MP0005083_abnormal_biliary_tract1.25253052
50MP0003111_abnormal_nucleus_morphology1.24834516
51MP0003436_decreased_susceptibility_to1.22279267
52MP0003656_abnormal_erythrocyte_physiolo1.22239841
53MP0001849_ear_inflammation1.22088884
54MP0006138_congestive_heart_failure1.21294574
55MP0005360_urolithiasis1.19155390
56MP0010234_abnormal_vibrissa_follicle1.18810393
57MP0003566_abnormal_cell_adhesion1.16148618
58MP0001661_extended_life_span1.14628509
59MP0005670_abnormal_white_adipose1.14496684
60MP0000003_abnormal_adipose_tissue1.14128765
61MP0003172_abnormal_lysosome_physiology1.13171058
62MP0002108_abnormal_muscle_morphology1.11004071
63MP0001851_eye_inflammation1.09619957
64MP0003283_abnormal_digestive_organ1.08194699
65* MP0008961_abnormal_basal_metabolism1.07613812
66MP0003300_gastrointestinal_ulcer1.07491659
67MP0000685_abnormal_immune_system1.07299550
68MP0009672_abnormal_birth_weight1.06875253
69MP0003091_abnormal_cell_migration1.06597613
70MP0003567_abnormal_fetal_cardiomyocyte1.06442852
71MP0000266_abnormal_heart_morphology1.06169164
72MP0004197_abnormal_fetal_growth/weight/1.05583277
73MP0009780_abnormal_chondrocyte_physiolo1.03385047
74MP0000013_abnormal_adipose_tissue1.00324250
75MP0000537_abnormal_urethra_morphology0.99086463
76MP0003252_abnormal_bile_duct0.98551917
77MP0004808_abnormal_hematopoietic_stem0.98176685
78MP0002332_abnormal_exercise_endurance0.97809020
79MP0002971_abnormal_brown_adipose0.97780821
80MP0002909_abnormal_adrenal_gland0.97386664
81MP0006036_abnormal_mitochondrial_physio0.96834766
82MP0001873_stomach_inflammation0.95541241
83MP0005085_abnormal_gallbladder_physiolo0.95033784
84MP0005365_abnormal_bile_salt0.94778111
85MP0001348_abnormal_lacrimal_gland0.94168041
86MP0002088_abnormal_embryonic_growth/wei0.93840236
87MP0003984_embryonic_growth_retardation0.93821461
88MP0001730_embryonic_growth_arrest0.92484474
89MP0004510_myositis0.92170347
90MP0000703_abnormal_thymus_morphology0.90711257
91MP0003806_abnormal_nucleotide_metabolis0.90140263
92MP0003077_abnormal_cell_cycle0.89340356
93MP0009840_abnormal_foam_cell0.86216702
94MP0005058_abnormal_lysosome_morphology0.84426306
95MP0000383_abnormal_hair_follicle0.82889942
96MP0005380_embryogenesis_phenotype0.82831081
97MP0001672_abnormal_embryogenesis/_devel0.82831081
98MP0005409_darkened_coat_color0.81006271
99MP0009278_abnormal_bone_marrow0.80843650
100MP0002127_abnormal_cardiovascular_syste0.80640687
101MP0005623_abnormal_meninges_morphology0.78944484
102MP0010307_abnormal_tumor_latency0.78617363
103MP0002398_abnormal_bone_marrow0.77932720
104MP0010094_abnormal_chromosome_stability0.77550359
105MP0009053_abnormal_anal_canal0.77416904
106MP0004947_skin_inflammation0.76923933
107MP0002166_altered_tumor_susceptibility0.75844290
108MP0001800_abnormal_humoral_immune0.75810873
109MP0010678_abnormal_skin_adnexa0.75154143
110* MP0004085_abnormal_heartbeat0.74956027
111MP0009384_cardiac_valve_regurgitation0.74595846
112MP0003183_abnormal_peptide_metabolism0.74197230
113MP0005248_abnormal_Harderian_gland0.74073357
114MP0003045_fibrosis0.73358686
115MP0003941_abnormal_skin_development0.72991118
116MP0000350_abnormal_cell_proliferation0.72820303
117MP0000767_abnormal_smooth_muscle0.72575230
118MP0002877_abnormal_melanocyte_morpholog0.72188505
119MP0003453_abnormal_keratinocyte_physiol0.71374096
120* MP0002078_abnormal_glucose_homeostasis0.71144343
121MP0000689_abnormal_spleen_morphology0.70916001
122MP0010368_abnormal_lymphatic_system0.70333080
123MP0002084_abnormal_developmental_patter0.70187694
124MP0001915_intracranial_hemorrhage0.69556867
125MP0002086_abnormal_extraembryonic_tissu0.69331531
126MP0000428_abnormal_craniofacial_morphol0.68761215
127* MP0000609_abnormal_liver_physiology0.68567410
128* MP0010329_abnormal_lipoprotein_level0.68034041
129MP0002128_abnormal_blood_circulation0.67504816
130MP0002925_abnormal_cardiovascular_devel0.67186490
131MP0003119_abnormal_digestive_system0.66463796
132MP0001697_abnormal_embryo_size0.64000653
133MP0002089_abnormal_postnatal_growth/wei0.60327426
134MP0001299_abnormal_eye_distance/0.60117168
135MP0005319_abnormal_enzyme/_coenzyme0.59995847
136MP0005266_abnormal_metabolism0.59962776
137MP0003115_abnormal_respiratory_system0.59376610
138MP0009703_decreased_birth_body0.57211004
139MP0002896_abnormal_bone_mineralization0.57201240
140MP0002080_prenatal_lethality0.55806846
141MP0003828_pulmonary_edema0.55232115
142MP0008770_decreased_survivor_rate0.54944421

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)6.37918883
2Exercise-induced muscle cramps (HP:0003710)6.12934295
3Muscle fiber inclusion bodies (HP:0100299)5.43219140
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.21607330
5Type 1 muscle fiber predominance (HP:0003803)5.09093042
6Hyporeflexia of lower limbs (HP:0002600)4.86732465
7Muscle hypertrophy of the lower extremities (HP:0008968)4.69789857
8Calf muscle hypertrophy (HP:0008981)4.67265867
9Difficulty running (HP:0009046)4.61326552
10Myoglobinuria (HP:0002913)4.56651139
11Nemaline bodies (HP:0003798)4.55940335
12Muscle fiber splitting (HP:0003555)4.42412961
13Increased connective tissue (HP:0009025)4.26753940
14Distal arthrogryposis (HP:0005684)4.25927173
15Sudden death (HP:0001699)4.10955126
16Myopathic facies (HP:0002058)3.99955721
17Ulnar deviation of the wrist (HP:0003049)3.80975625
18Round ear (HP:0100830)3.67147121
19Abnormality of the left ventricular outflow tract (HP:0011103)3.66130876
20Subaortic stenosis (HP:0001682)3.66130876
21EMG: myopathic abnormalities (HP:0003458)3.60821865
22Abnormality of the calf musculature (HP:0001430)3.60533086
23Difficulty climbing stairs (HP:0003551)3.60333787
24Rhabdomyolysis (HP:0003201)3.48617046
25Asymmetric septal hypertrophy (HP:0001670)3.29843560
26Myotonia (HP:0002486)3.22668769
27Ventricular tachycardia (HP:0004756)3.18368098
28Muscle stiffness (HP:0003552)3.07810982
29Abnormality of skeletal muscle fiber size (HP:0012084)2.99134382
30Increased variability in muscle fiber diameter (HP:0003557)2.93861742
31Bundle branch block (HP:0011710)2.91842399
32Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.90650600
33Increased neuronal autofluorescent lipopigment (HP:0002074)2.84802222
34Right ventricular cardiomyopathy (HP:0011663)2.79603670
35Frequent falls (HP:0002359)2.78652667
36Pelvic girdle muscle weakness (HP:0003749)2.76502245
37EMG: neuropathic changes (HP:0003445)2.72350718
38Absent phalangeal crease (HP:0006109)2.71361319
39Shoulder girdle muscle weakness (HP:0003547)2.69283334
40Calcaneovalgus deformity (HP:0001848)2.64881227
41Mildly elevated creatine phosphokinase (HP:0008180)2.57908827
42Increased cerebral lipofuscin (HP:0011813)2.57078354
43Abnormality of the fingertips (HP:0001211)2.53515459
44Abnormality of the hip-girdle musculature (HP:0001445)2.52979577
45Abnormality of the musculature of the pelvis (HP:0001469)2.52979577
46Limb-girdle muscle atrophy (HP:0003797)2.51318161
47Hypoplastic ischia (HP:0003175)2.45325335
48Areflexia of lower limbs (HP:0002522)2.44551235
49Rimmed vacuoles (HP:0003805)2.42203549
50Deformed tarsal bones (HP:0008119)2.37887337
51Limb-girdle muscle weakness (HP:0003325)2.35668977
52Neck muscle weakness (HP:0000467)2.30613961
53Proximal amyotrophy (HP:0007126)2.29261072
54Hyperacusis (HP:0010780)2.26921867
55Abnormality of the calcaneus (HP:0008364)2.26704604
56Atrioventricular block (HP:0001678)2.20984193
57Lipoatrophy (HP:0100578)2.20587177
58Scapular winging (HP:0003691)2.19753430
59Progressive external ophthalmoplegia (HP:0000590)2.17985550
60Abnormal finger flexion creases (HP:0006143)2.16754862
61Abnormality of the ischium (HP:0003174)2.15945758
62Rectal prolapse (HP:0002035)2.14331139
63Heart block (HP:0012722)2.14329422
64Dysmetric saccades (HP:0000641)2.10570568
65Fatigue (HP:0012378)2.09377314
66Malignant hyperthermia (HP:0002047)2.09331593
67Lower limb amyotrophy (HP:0007210)2.08744461
68Ventricular arrhythmia (HP:0004308)2.07952752
69Facial diplegia (HP:0001349)2.06192858
70Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.04506505
71Ventricular fibrillation (HP:0001663)2.02253358
72Atrial fibrillation (HP:0005110)2.02063990
73Clumsiness (HP:0002312)2.01774963
74Abnormal atrioventricular conduction (HP:0005150)2.01570244
75Flat acetabular roof (HP:0003180)2.00709836
76Abnormal delayed hypersensitivity skin test (HP:0002963)2.00364589
77Gout (HP:0001997)1.99733632
78Cerebral aneurysm (HP:0004944)1.95324947
79Dilated cardiomyopathy (HP:0001644)1.92504692
80Dislocated radial head (HP:0003083)1.92188964
81Distal lower limb amyotrophy (HP:0008944)1.91966534
82Easy fatigability (HP:0003388)1.91385845
83Broad metatarsal (HP:0001783)1.90527825
84Lymphangioma (HP:0100764)1.89529593
85Primary atrial arrhythmia (HP:0001692)1.89240781
86Achilles tendon contracture (HP:0001771)1.88280495
87Abnormality of the lower motor neuron (HP:0002366)1.86975826
88Distal lower limb muscle weakness (HP:0009053)1.86620177
89Spinal rigidity (HP:0003306)1.85136749
90Abnormality of the Achilles tendon (HP:0005109)1.84785068
91Hamartoma of the eye (HP:0010568)1.83730572
92Hyperglycemia (HP:0003074)1.83585115
93Centrally nucleated skeletal muscle fibers (HP:0003687)1.82815531
94Palpitations (HP:0001962)1.81658268
95Hyperkalemia (HP:0002153)1.80618823
96Distal upper limb amyotrophy (HP:0007149)1.80435631
97Upper limb amyotrophy (HP:0009129)1.80435631
98Elfin facies (HP:0004428)1.79802133
99Cholelithiasis (HP:0001081)1.77820916
100Supraventricular arrhythmia (HP:0005115)1.77499746
101Supraventricular tachycardia (HP:0004755)1.77305571
102Abnormality of the shoulder girdle musculature (HP:0001435)1.74947496
103Ketoacidosis (HP:0001993)1.74163306
104Cystic hygroma (HP:0000476)1.74025239
105Aortic aneurysm (HP:0004942)1.73893675
106Progressive muscle weakness (HP:0003323)1.73010631
107Heterotopia (HP:0002282)1.72639101
108Generalized muscle weakness (HP:0003324)1.71881916
109Syncope (HP:0001279)1.71737953
110Abnormality of the radial head (HP:0003995)1.71464824
111Muscular dystrophy (HP:0003560)1.71224572
112Metatarsus adductus (HP:0001840)1.70875968
113Slender build (HP:0001533)1.70778364
114Increased density of long bones (HP:0006392)1.70465440
115Ulnar deviation of finger (HP:0009465)1.70419744
116Ependymoma (HP:0002888)1.68864570
117Anal stenosis (HP:0002025)1.68613120
118Vertebral arch anomaly (HP:0008438)1.67676879
119Persistence of primary teeth (HP:0006335)1.64224485
120Nonprogressive disorder (HP:0003680)1.60630132
121Weak cry (HP:0001612)1.58683077
122Asymmetry of the thorax (HP:0001555)1.56715542
123Fetal akinesia sequence (HP:0001989)1.56155499
124Thin ribs (HP:0000883)1.54498009
125Trigonocephaly (HP:0000243)1.54114229
126Gowers sign (HP:0003391)1.53310241
127Stridor (HP:0010307)1.53105273
128Popliteal pterygium (HP:0009756)1.52637450
129Intestinal fistula (HP:0100819)1.51693831
130Bulbar palsy (HP:0001283)1.50470584
131Arterial tortuosity (HP:0005116)1.50378848
132Eczematoid dermatitis (HP:0000976)1.48694047
133Subacute progressive viral hepatitis (HP:0006572)1.47146541
134Syringomyelia (HP:0003396)1.44781609
135Spinal cord lesions (HP:0100561)1.44781609
136Urinary glycosaminoglycan excretion (HP:0003541)1.44094263
137Mucopolysacchariduria (HP:0008155)1.44094263
138Long clavicles (HP:0000890)1.43368979
139Aneurysm (HP:0002617)1.43305249
140Prominent nose (HP:0000448)1.42664040

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.83576409
2TRIB34.46174199
3OBSCN3.53262454
4PKN23.40132713
5PHKG12.91334322
6PHKG22.91334322
7NEK12.81467176
8SMG12.55931808
9EEF2K2.54454941
10MAP3K102.34100643
11CDK122.27462747
12PDK42.16916038
13PDK32.16916038
14PRPF4B1.99265303
15RIPK11.92937161
16LMTK21.77442272
17PTK61.75807954
18MAP2K31.69112949
19MAP3K71.68045399
20DMPK1.61825489
21PDGFRA1.58844266
22MELK1.52525539
23SIK11.50897246
24LATS11.38461488
25TAOK11.31047312
26MAP3K141.25323760
27CCNB11.24612381
28LATS21.19832946
29MTOR1.19650220
30ERN11.18201920
31BLK1.16970240
32AKT31.15450525
33ICK1.14021222
34FGFR41.12494561
35ZAP701.12099721
36KSR21.10168770
37MAP4K11.09826389
38BCKDK1.09490072
39NLK1.08592320
40BRD41.06745449
41PIK3CG1.05434893
42MAP2K41.00475601
43PRKD30.99471447
44CDK90.98783098
45CAMK1D0.97149015
46CAMK1G0.93997200
47MARK20.93821313
48MAP3K30.93096426
49ALK0.92062474
50PRKAA10.91340272
51PDK20.91296611
52RET0.89956958
53MKNK20.88302215
54NME10.87061107
55MAP3K90.86933626
56MUSK0.83589844
57MAP3K20.79009561
58TYK20.78062283
59GRK60.77759363
60HIPK20.77380786
61MAP2K20.77017846
62PAK60.75979158
63STK380.75059570
64FGFR10.74829118
65TRPM70.74581964
66NEK20.74421885
67MAPK120.74257105
68MAPKAPK30.73684094
69LRRK20.73523586
70CDK80.72605903
71CDK60.67972111
72PTK20.67865757
73STK240.67395100
74PDGFRB0.65298031
75EPHA20.65249125
76BMX0.63700692
77CDC42BPA0.63380047
78SIK30.63256925
79PAK30.62159201
80CDK40.61999264
81KSR10.61224121
82PRKD20.61055236
83RPS6KA60.61030686
84FGFR30.60932376
85TYRO30.60892467
86RPS6KL10.60234321
87RPS6KC10.60234321
88IRAK10.58923383
89HCK0.58672803
90MAPK70.57651303
91STK30.57313481
92PIK3CA0.56554807
93PRKAA20.55815415
94FES0.54640162
95MAPK110.53706674
96SGK30.53465668
97CDK70.53146222
98PRKD10.53140109
99PRKCH0.52719288
100EPHB10.51946610
101PAK40.51769014
102MAP3K40.50688358
103MAP3K50.50538197
104AKT20.49719280
105FGR0.49412232
106CAMK40.49277757
107CSK0.48381819
108TBK10.48270698
109FLT30.48183320
110RPS6KA20.47607359
111CSF1R0.47578157
112DAPK20.47039220
113IRAK30.46711592
114WNK10.45557266
115MAP3K60.44617994
116FER0.44443062
117RPS6KA10.43731272
118RPS6KB20.43673968
119SGK20.43492575
120CAMKK10.43400646
121JAK10.43108865
122ILK0.41672905
123MAP2K10.41004905
124PDPK10.40877244
125BTK0.40332699
126MAPKAPK20.40021029
127PAK20.39456746
128PINK10.39316855
129MAP3K10.37606990
130FGFR20.36582213
131FRK0.36373133
132JAK30.36044609
133EPHA30.35905554
134RPS6KB10.35877717
135STK110.35456763
136BMPR1B0.35211616
137SCYL20.34471743
138MAP3K80.34043942
139ROCK10.33985515
140SIK20.33798516
141DYRK1B0.33789733
142JAK20.33675718
143MAP3K110.33486590
144PDK10.33365251
145NEK90.33058710
146STK38L0.32131204
147RPS6KA30.31638882

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.77089918
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.42531033
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.39587025
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.31928953
5Dilated cardiomyopathy_Homo sapiens_hsa054142.25946219
6Fatty acid degradation_Homo sapiens_hsa000712.09487819
7Carbon metabolism_Homo sapiens_hsa012002.02383629
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.01475221
9Insulin resistance_Homo sapiens_hsa049311.94539047
10Other glycan degradation_Homo sapiens_hsa005111.93265570
11Propanoate metabolism_Homo sapiens_hsa006401.87999909
12Lysine degradation_Homo sapiens_hsa003101.85704252
13mTOR signaling pathway_Homo sapiens_hsa041501.78671705
14Insulin signaling pathway_Homo sapiens_hsa049101.70850988
15Glucagon signaling pathway_Homo sapiens_hsa049221.68911353
16Nitrogen metabolism_Homo sapiens_hsa009101.67729471
17Pancreatic cancer_Homo sapiens_hsa052121.65240611
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63874602
19Biosynthesis of amino acids_Homo sapiens_hsa012301.63580188
20Arginine biosynthesis_Homo sapiens_hsa002201.62879338
21Thyroid cancer_Homo sapiens_hsa052161.62338216
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.59322074
23Fatty acid metabolism_Homo sapiens_hsa012121.57344111
24Non-homologous end-joining_Homo sapiens_hsa034501.51275070
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.50351399
26AMPK signaling pathway_Homo sapiens_hsa041521.50219261
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.42705489
28B cell receptor signaling pathway_Homo sapiens_hsa046621.42533448
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42527475
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37628989
31Pyruvate metabolism_Homo sapiens_hsa006201.36328784
32Type II diabetes mellitus_Homo sapiens_hsa049301.35295275
33Starch and sucrose metabolism_Homo sapiens_hsa005001.33651850
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.31916298
35Viral myocarditis_Homo sapiens_hsa054161.28584786
36Longevity regulating pathway - mammal_Homo sapiens_hsa042111.28407574
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21374059
38Cardiac muscle contraction_Homo sapiens_hsa042601.21083835
39Prostate cancer_Homo sapiens_hsa052151.19752410
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.17841366
41PPAR signaling pathway_Homo sapiens_hsa033201.17580813
42T cell receptor signaling pathway_Homo sapiens_hsa046601.13431774
43mRNA surveillance pathway_Homo sapiens_hsa030151.08282718
44Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06998824
45Focal adhesion_Homo sapiens_hsa045101.06012543
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03094870
47Tryptophan metabolism_Homo sapiens_hsa003801.01920824
48Hepatitis B_Homo sapiens_hsa051611.00410831
49Hepatitis C_Homo sapiens_hsa051601.00281077
50Osteoclast differentiation_Homo sapiens_hsa043800.98579363
51Adherens junction_Homo sapiens_hsa045200.98039709
52Oxytocin signaling pathway_Homo sapiens_hsa049210.96955447
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96818462
54Chronic myeloid leukemia_Homo sapiens_hsa052200.96362694
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.96020576
56Choline metabolism in cancer_Homo sapiens_hsa052310.95822984
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95705503
58Inositol phosphate metabolism_Homo sapiens_hsa005620.95249924
59Herpes simplex infection_Homo sapiens_hsa051680.94582682
60Bile secretion_Homo sapiens_hsa049760.94251410
61TNF signaling pathway_Homo sapiens_hsa046680.94017939
62Platelet activation_Homo sapiens_hsa046110.93342855
63Measles_Homo sapiens_hsa051620.93314827
64Butanoate metabolism_Homo sapiens_hsa006500.91772002
65Dorso-ventral axis formation_Homo sapiens_hsa043200.87876739
66Selenocompound metabolism_Homo sapiens_hsa004500.87856307
67VEGF signaling pathway_Homo sapiens_hsa043700.86938518
68Proteoglycans in cancer_Homo sapiens_hsa052050.86361836
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85151728
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84474113
71Tight junction_Homo sapiens_hsa045300.84240025
72Apoptosis_Homo sapiens_hsa042100.83546250
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83161123
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82665322
75Endometrial cancer_Homo sapiens_hsa052130.82585639
76HIF-1 signaling pathway_Homo sapiens_hsa040660.81451201
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80323678
78ErbB signaling pathway_Homo sapiens_hsa040120.79987729
79Fructose and mannose metabolism_Homo sapiens_hsa000510.78655490
80Viral carcinogenesis_Homo sapiens_hsa052030.78302597
81Fat digestion and absorption_Homo sapiens_hsa049750.77405838
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.76205299
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74545646
84Non-small cell lung cancer_Homo sapiens_hsa052230.74311789
85Circadian rhythm_Homo sapiens_hsa047100.74210125
86FoxO signaling pathway_Homo sapiens_hsa040680.74182969
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73930123
88Influenza A_Homo sapiens_hsa051640.73523448
89Toxoplasmosis_Homo sapiens_hsa051450.72723407
90MAPK signaling pathway_Homo sapiens_hsa040100.70833952
91Fatty acid biosynthesis_Homo sapiens_hsa000610.69964372
92Renal cell carcinoma_Homo sapiens_hsa052110.69458412
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68773660
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67344551
95Galactose metabolism_Homo sapiens_hsa000520.66941580
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.64545642
97GnRH signaling pathway_Homo sapiens_hsa049120.64480132
98Glioma_Homo sapiens_hsa052140.64094220
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63839904
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.63702240
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.63455312
102Amoebiasis_Homo sapiens_hsa051460.62510309
103HTLV-I infection_Homo sapiens_hsa051660.61742519
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.61677057
105Pathways in cancer_Homo sapiens_hsa052000.58669709
106Small cell lung cancer_Homo sapiens_hsa052220.58287025
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58136252
108Estrogen signaling pathway_Homo sapiens_hsa049150.57608749
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57322325
110Endocytosis_Homo sapiens_hsa041440.57211420
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56715122
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.56579416
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55900175
114Primary immunodeficiency_Homo sapiens_hsa053400.55447357
115Prolactin signaling pathway_Homo sapiens_hsa049170.54741134
116Pentose phosphate pathway_Homo sapiens_hsa000300.53635841
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53492559
118ABC transporters_Homo sapiens_hsa020100.52859616
119Hippo signaling pathway_Homo sapiens_hsa043900.52413235
120Insulin secretion_Homo sapiens_hsa049110.52407902
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.52283721
122Legionellosis_Homo sapiens_hsa051340.52162997
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51345547
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50096101
125Notch signaling pathway_Homo sapiens_hsa043300.49947410
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49833383
127Chemokine signaling pathway_Homo sapiens_hsa040620.49298923
128Gastric acid secretion_Homo sapiens_hsa049710.48700912
129Lysosome_Homo sapiens_hsa041420.47864908
130p53 signaling pathway_Homo sapiens_hsa041150.46742814
131Glycerolipid metabolism_Homo sapiens_hsa005610.46497670
132MicroRNAs in cancer_Homo sapiens_hsa052060.45515722
133Bladder cancer_Homo sapiens_hsa052190.45371924
134Acute myeloid leukemia_Homo sapiens_hsa052210.44401999
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42397356
136ECM-receptor interaction_Homo sapiens_hsa045120.41072878
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.40853977
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.40851087
139Colorectal cancer_Homo sapiens_hsa052100.40784354
140Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40138972
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39953074
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39030920
143Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37847057
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36265690
145Basal cell carcinoma_Homo sapiens_hsa052170.36243297

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