HIGD1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.75225969
2ATP synthesis coupled proton transport (GO:0015986)8.25747689
3energy coupled proton transport, down electrochemical gradient (GO:0015985)8.25747689
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.99718346
5respiratory electron transport chain (GO:0022904)7.14518440
6electron transport chain (GO:0022900)6.98220815
7protein neddylation (GO:0045116)5.32065617
8chaperone-mediated protein transport (GO:0072321)5.21901110
9hydrogen ion transmembrane transport (GO:1902600)4.64549600
10ATP biosynthetic process (GO:0006754)4.58522658
11protein complex biogenesis (GO:0070271)4.55413990
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.48470727
13mitochondrial respiratory chain complex I assembly (GO:0032981)4.35617139
14NADH dehydrogenase complex assembly (GO:0010257)4.35617139
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.35617139
16dopamine transport (GO:0015872)4.33610143
17ATP hydrolysis coupled proton transport (GO:0015991)4.23709619
18energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.23709619
19purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.22147500
20purine nucleoside triphosphate biosynthetic process (GO:0009145)4.15857492
21proton transport (GO:0015992)4.11570654
22inner mitochondrial membrane organization (GO:0007007)4.09670919
23mitochondrial respiratory chain complex assembly (GO:0033108)4.06250050
24hydrogen transport (GO:0006818)4.03922276
25neuron cell-cell adhesion (GO:0007158)3.98681035
26oxidative phosphorylation (GO:0006119)3.90735873
27dopamine biosynthetic process (GO:0042416)3.83571255
28ribonucleoside triphosphate biosynthetic process (GO:0009201)3.60694689
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.58988355
30L-phenylalanine catabolic process (GO:0006559)3.58988355
31long-chain fatty acid biosynthetic process (GO:0042759)3.56444351
32L-methionine salvage (GO:0071267)3.52749066
33L-methionine biosynthetic process (GO:0071265)3.52749066
34amino acid salvage (GO:0043102)3.52749066
35synaptic vesicle exocytosis (GO:0016079)3.49005352
36fatty acid elongation (GO:0030497)3.47091741
37L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.46281028
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.45288266
39L-phenylalanine metabolic process (GO:0006558)3.45288266
40regulation of dopamine metabolic process (GO:0042053)3.28319585
41regulation of catecholamine metabolic process (GO:0042069)3.28319585
42regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.21849801
43DNA double-strand break processing (GO:0000729)3.21532033
44transferrin transport (GO:0033572)3.16081266
45presynaptic membrane assembly (GO:0097105)3.15525061
46glyoxylate metabolic process (GO:0046487)3.12187256
47nucleoside triphosphate biosynthetic process (GO:0009142)3.11772993
48cullin deneddylation (GO:0010388)3.10885100
49regulation of acyl-CoA biosynthetic process (GO:0050812)3.08893748
50regulation of cofactor metabolic process (GO:0051193)3.08707766
51regulation of coenzyme metabolic process (GO:0051196)3.08707766
52branched-chain amino acid catabolic process (GO:0009083)3.05650466
53vocalization behavior (GO:0071625)3.05481234
54water-soluble vitamin biosynthetic process (GO:0042364)3.05242697
55substantia nigra development (GO:0021762)3.05032156
56pteridine-containing compound biosynthetic process (GO:0042559)3.03343981
57synaptic transmission, dopaminergic (GO:0001963)3.03219773
58negative regulation of synaptic transmission, GABAergic (GO:0032229)3.02762857
59cellular glucuronidation (GO:0052695)3.02192476
60aerobic respiration (GO:0009060)2.98854405
61respiratory chain complex IV assembly (GO:0008535)2.98537985
62presynaptic membrane organization (GO:0097090)2.97427797
63behavioral response to cocaine (GO:0048148)2.97002260
64uronic acid metabolic process (GO:0006063)2.95751827
65glucuronate metabolic process (GO:0019585)2.95751827
66negative regulation of neurotransmitter transport (GO:0051589)2.95194974
67regulation of cellular amino acid metabolic process (GO:0006521)2.94946039
68GTP biosynthetic process (GO:0006183)2.94834449
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93679368
70negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.93045626
71aldehyde catabolic process (GO:0046185)2.92984359
72trivalent inorganic cation transport (GO:0072512)2.92446853
73ferric iron transport (GO:0015682)2.92446853
74protein targeting to mitochondrion (GO:0006626)2.92072037
75cholesterol biosynthetic process (GO:0006695)2.91831201
76regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.91538405
77establishment of protein localization to mitochondrion (GO:0072655)2.87858390
78positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87813338
79lactate metabolic process (GO:0006089)2.87291746
80regulation of sulfur metabolic process (GO:0042762)2.85831875
81catecholamine transport (GO:0051937)2.85704953
82gamma-aminobutyric acid signaling pathway (GO:0007214)2.84268128
83positive regulation of synapse assembly (GO:0051965)2.83545909
84ribosomal small subunit biogenesis (GO:0042274)2.83323416
85mitochondrial transport (GO:0006839)2.83137921
86cytochrome complex assembly (GO:0017004)2.81559361
87sterol biosynthetic process (GO:0016126)2.81202733
88protein localization to mitochondrion (GO:0070585)2.80691619
89peptidyl-cysteine modification (GO:0018198)2.78239632
90protein-cofactor linkage (GO:0018065)2.78013946
91proteasome assembly (GO:0043248)2.77359363
92regulation of mitochondrial translation (GO:0070129)2.77218776
93axon ensheathment in central nervous system (GO:0032291)2.75262848
94central nervous system myelination (GO:0022010)2.75262848
95positive regulation of mitochondrial fission (GO:0090141)2.73892091
96protein deneddylation (GO:0000338)2.73878243
97regulation of cell communication by electrical coupling (GO:0010649)2.72503822
98methionine biosynthetic process (GO:0009086)2.72222421
99neuronal action potential propagation (GO:0019227)2.70313397
100response to cocaine (GO:0042220)2.70225545
101anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.68566999
102phagosome maturation (GO:0090382)2.64566201
103regulation of glutamate secretion (GO:0014048)2.64412231
104aspartate family amino acid biosynthetic process (GO:0009067)2.63862318
105regulation of oxidative phosphorylation (GO:0002082)2.63813556
106protein localization to synapse (GO:0035418)2.62139436
107regulation of cellular respiration (GO:0043457)2.62095475
108generation of precursor metabolites and energy (GO:0006091)2.61780218
109negative regulation of ligase activity (GO:0051352)2.60407328
110negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.60407328
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.58769804
112neurotransmitter biosynthetic process (GO:0042136)2.58744471
113phenol-containing compound catabolic process (GO:0019336)2.58493814
114neurotransmitter uptake (GO:0001504)2.57841077
115xenobiotic catabolic process (GO:0042178)2.57819028
116ribosome assembly (GO:0042255)2.57412332
117positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.57238937
118tricarboxylic acid cycle (GO:0006099)2.55594481
119methionine metabolic process (GO:0006555)2.55533618
120alkaloid metabolic process (GO:0009820)2.55138831
121vascular smooth muscle contraction (GO:0014829)2.55074565
122short-term memory (GO:0007614)2.54242758
123regulation of protein kinase A signaling (GO:0010738)2.53810693
124calcium-mediated signaling using intracellular calcium source (GO:0035584)2.52086712
125cellular ketone body metabolic process (GO:0046950)2.51807550
126neurotransmitter catabolic process (GO:0042135)2.51379844
127catechol-containing compound biosynthetic process (GO:0009713)2.51326753
128catecholamine biosynthetic process (GO:0042423)2.51326753
129regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.50571021
130regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.50571021
131platelet dense granule organization (GO:0060155)2.50494476
132response to insecticide (GO:0017085)2.50486198
133mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.49307926
134NADH metabolic process (GO:0006734)2.49254626
135glutamate secretion (GO:0014047)2.49075125
136S-adenosylmethionine metabolic process (GO:0046500)2.48178317
137positive regulation of ligase activity (GO:0051351)2.48007564
138succinate metabolic process (GO:0006105)2.47100177
139neuron-neuron synaptic transmission (GO:0007270)2.46931946
140lipid particle organization (GO:0034389)2.46257348
141protein localization to cilium (GO:0061512)2.45507979
142ketone body metabolic process (GO:1902224)2.43893362
143purine nucleoside monophosphate biosynthetic process (GO:0009127)2.43809816
144purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.43809816
145regulation of voltage-gated calcium channel activity (GO:1901385)2.43621914
146oxaloacetate metabolic process (GO:0006107)2.41076101
147cellular respiration (GO:0045333)2.41043642
148response to nitrosative stress (GO:0051409)2.39298771
149regulation of short-term neuronal synaptic plasticity (GO:0048172)2.38502502
150DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.38246241
151signal peptide processing (GO:0006465)2.38067864
152positive regulation of action potential (GO:0045760)2.37735264
153CENP-A containing nucleosome assembly (GO:0034080)2.36045066
154sulfur amino acid biosynthetic process (GO:0000097)2.35595878
155C4-dicarboxylate transport (GO:0015740)2.35527779
156negative regulation of heart rate (GO:0010459)2.34261962
157branched-chain amino acid metabolic process (GO:0009081)2.33517603
158signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.32714325
159signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.32714325
160signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.32714325
161signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.31374588
162intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.31374588
163chromatin remodeling at centromere (GO:0031055)2.30049026
164regulation of cellular amine metabolic process (GO:0033238)2.29288189
165regulation of ubiquitin-protein transferase activity (GO:0051438)2.27878786
166fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.27353442
167polyketide metabolic process (GO:0030638)2.26474770
168doxorubicin metabolic process (GO:0044598)2.26474770
169daunorubicin metabolic process (GO:0044597)2.26474770
170artery smooth muscle contraction (GO:0014824)2.26057435
171nucleotide transmembrane transport (GO:1901679)2.24366198
172response to redox state (GO:0051775)2.23537087
173regulation of ligase activity (GO:0051340)2.21399775

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.80296031
2GBX2_23144817_ChIP-Seq_PC3_Human3.53876927
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.38119788
4TAF15_26573619_Chip-Seq_HEK293_Human3.01312919
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.67347813
6VDR_22108803_ChIP-Seq_LS180_Human2.56692701
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.53742670
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.49908178
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47548253
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.41532391
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.38248457
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.37858773
13ELK1_19687146_ChIP-ChIP_HELA_Human2.34499317
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28572810
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.23644825
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19031152
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.13922287
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06901285
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05295673
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04669975
21FUS_26573619_Chip-Seq_HEK293_Human2.02998367
22* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.02640296
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01922919
24CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00985899
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.00965103
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96963171
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.93596573
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.90355780
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.86295603
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81674188
31AR_21909140_ChIP-Seq_LNCAP_Human1.79717960
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78889248
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77306526
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77306526
35P300_19829295_ChIP-Seq_ESCs_Human1.74348049
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73072120
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.67738646
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67359187
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59432777
40REST_21632747_ChIP-Seq_MESCs_Mouse1.59270560
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58976243
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.58464904
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58458795
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.58138606
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56405939
46ER_23166858_ChIP-Seq_MCF-7_Human1.55911722
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.55343643
48HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.53958441
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53149017
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52482555
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51456416
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50495542
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.50061320
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.47358946
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45712327
56VDR_23849224_ChIP-Seq_CD4+_Human1.43985969
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42731955
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.42232811
59ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.41970755
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41765093
61FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.40337767
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38567261
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37575758
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.37017491
65REST_18959480_ChIP-ChIP_MESCs_Mouse1.34788980
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34608584
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.33890614
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.33863395
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.32528945
70JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32469826
71SMAD4_21799915_ChIP-Seq_A2780_Human1.32298514
72CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31055189
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29217458
74IGF1R_20145208_ChIP-Seq_DFB_Human1.29097767
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29047896
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26520476
77RNF2_27304074_Chip-Seq_NSC_Mouse1.25628910
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25380989
79DCP1A_22483619_ChIP-Seq_HELA_Human1.25071826
80JUN_21703547_ChIP-Seq_K562_Human1.23483350
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.23224287
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.22913578
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22317555
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21621777
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20715612
86RNF2_27304074_Chip-Seq_ESCs_Mouse1.18991240
87AR_21572438_ChIP-Seq_LNCaP_Human1.18747067
88CRX_20693478_ChIP-Seq_RETINA_Mouse1.16599228
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16131170
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15814162
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14793978
92KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13492504
93ETS1_20019798_ChIP-Seq_JURKAT_Human1.13184678
94MYC_18940864_ChIP-ChIP_HL60_Human1.12484103
95HTT_18923047_ChIP-ChIP_STHdh_Human1.10793947
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10652886
97* CDX2_22108803_ChIP-Seq_LS180_Human1.10598852
98STAT3_18555785_Chip-Seq_ESCs_Mouse1.10488389
99FOXP3_21729870_ChIP-Seq_TREG_Human1.10334974
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10285287
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09690172
102SOX2_18555785_Chip-Seq_ESCs_Mouse1.09129314
103MYC_18555785_ChIP-Seq_MESCs_Mouse1.08225392
104RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06360109
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05660826
106NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03932547
107EWS_26573619_Chip-Seq_HEK293_Human1.03327949
108CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02880344
109CMYC_18555785_Chip-Seq_ESCs_Mouse1.02861056
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02820347
111HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02623510
112NANOG_16153702_ChIP-ChIP_HESCs_Human1.02561016
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01773879
114SRF_21415370_ChIP-Seq_HL-1_Mouse1.01559489
115ZNF274_21170338_ChIP-Seq_K562_Hela1.00520008
116NANOG_18555785_Chip-Seq_ESCs_Mouse1.00394061
117E2F1_18555785_Chip-Seq_ESCs_Mouse1.00266998
118EOMES_21245162_ChIP-Seq_HESCs_Human1.00252731
119POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00136627
120TCF4_22108803_ChIP-Seq_LS180_Human0.99731906
121EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99467620
122SALL4_22934838_ChIP-ChIP_CD34+_Human0.99443823
123FOXA1_25329375_ChIP-Seq_VCAP_Human0.98948244
124FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98948244
125P300_18555785_Chip-Seq_ESCs_Mouse0.98479143
126AR_25329375_ChIP-Seq_VCAP_Human0.98248658
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.98101212
128CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97819296
129MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96684361
130ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96528299
131EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96494259
132TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96075843
133CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95964878
134NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95887540
135* IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95106852
136OCT4_18555785_Chip-Seq_ESCs_Mouse0.95040399
137SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.94938377
138SOX2_19829295_ChIP-Seq_ESCs_Human0.91712041
139NANOG_19829295_ChIP-Seq_ESCs_Human0.91712041
140THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91602805
141P53_22387025_ChIP-Seq_ESCs_Mouse0.91332191
142TAL1_26923725_Chip-Seq_HPCs_Mouse0.90139248
143TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89790113
144ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87786665
145SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87224622
146PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87198908
147RUNX2_22187159_ChIP-Seq_PCA_Human0.87108082
148ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.87066800
149BCAT_22108803_ChIP-Seq_LS180_Human0.87000212
150ELK1_22589737_ChIP-Seq_MCF10A_Human0.86541499
151ERG_21242973_ChIP-ChIP_JURKAT_Human0.86094407

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.26995815
2MP0001529_abnormal_vocalization3.88356746
3MP0002139_abnormal_hepatobiliary_system3.70928674
4MP0002822_catalepsy3.27862242
5MP0001905_abnormal_dopamine_level3.19190196
6MP0006276_abnormal_autonomic_nervous3.16392221
7MP0003195_calcinosis3.08618884
8MP0002736_abnormal_nociception_after2.76157632
9MP0001968_abnormal_touch/_nociception2.70737960
10MP0009046_muscle_twitch2.64839980
11MP0009745_abnormal_behavioral_response2.60430519
12MP0002837_dystrophic_cardiac_calcinosis2.54660150
13MP0002064_seizures2.51930194
14MP0003806_abnormal_nucleotide_metabolis2.48477255
15MP0003635_abnormal_synaptic_transmissio2.37557535
16MP0009379_abnormal_foot_pigmentation2.37031068
17MP0002272_abnormal_nervous_system2.28467656
18MP0010234_abnormal_vibrissa_follicle2.27795950
19MP0004147_increased_porphyrin_level2.22330895
20MP0005085_abnormal_gallbladder_physiolo2.22050216
21MP0004859_abnormal_synaptic_plasticity2.21609994
22MP0005365_abnormal_bile_salt2.19281547
23MP0009780_abnormal_chondrocyte_physiolo2.18332545
24MP0002734_abnormal_mechanical_nocicepti2.15125750
25MP0003646_muscle_fatigue2.05142329
26MP0001440_abnormal_grooming_behavior2.04475888
27MP0002572_abnormal_emotion/affect_behav2.02263617
28MP0003186_abnormal_redox_activity2.02097357
29MP0003890_abnormal_embryonic-extraembry1.99384987
30MP0005332_abnormal_amino_acid1.97756000
31MP0001486_abnormal_startle_reflex1.95710623
32MP0004142_abnormal_muscle_tone1.93364621
33MP0002063_abnormal_learning/memory/cond1.92518474
34MP0002735_abnormal_chemical_nociception1.90749840
35MP0006054_spinal_hemorrhage1.90673010
36MP0004270_analgesia1.89498065
37MP0001984_abnormal_olfaction1.88891058
38MP0001501_abnormal_sleep_pattern1.86675895
39MP0004924_abnormal_behavior1.77731019
40MP0005386_behavior/neurological_phenoty1.77731019
41MP0008875_abnormal_xenobiotic_pharmacok1.76824627
42MP0001188_hyperpigmentation1.76714779
43MP0003718_maternal_effect1.76122087
44MP0003941_abnormal_skin_development1.72994648
45MP0003011_delayed_dark_adaptation1.72638091
46MP0005423_abnormal_somatic_nervous1.68645473
47MP0002067_abnormal_sensory_capabilities1.67333930
48MP0001970_abnormal_pain_threshold1.66382204
49MP0005171_absent_coat_pigmentation1.65952850
50MP0008058_abnormal_DNA_repair1.65271546
51MP0000751_myopathy1.64015542
52MP0010329_abnormal_lipoprotein_level1.62059585
53MP0004957_abnormal_blastocyst_morpholog1.58692307
54MP0002733_abnormal_thermal_nociception1.56975556
55MP0003122_maternal_imprinting1.51893468
56MP0004215_abnormal_myocardial_fiber1.50769101
57MP0006036_abnormal_mitochondrial_physio1.49977684
58MP0002638_abnormal_pupillary_reflex1.46884030
59MP0008877_abnormal_DNA_methylation1.46862097
60MP0006035_abnormal_mitochondrial_morpho1.45150112
61MP0008789_abnormal_olfactory_epithelium1.42644649
62MP0003868_abnormal_feces_composition1.42248663
63MP0005636_abnormal_mineral_homeostasis1.40023363
64MP0004036_abnormal_muscle_relaxation1.39348207
65MP0005551_abnormal_eye_electrophysiolog1.38716341
66MP0005408_hypopigmentation1.37957230
67MP0002163_abnormal_gland_morphology1.37640192
68MP0002332_abnormal_exercise_endurance1.36371613
69MP0005394_taste/olfaction_phenotype1.35819853
70MP0005499_abnormal_olfactory_system1.35819853
71MP0004742_abnormal_vestibular_system1.35469084
72MP0002184_abnormal_innervation1.32537844
73MP0004019_abnormal_vitamin_homeostasis1.32461579
74MP0003136_yellow_coat_color1.31915601
75MP0005084_abnormal_gallbladder_morpholo1.30730813
76MP0008932_abnormal_embryonic_tissue1.30658323
77MP0004484_altered_response_of1.29752539
78MP0001764_abnormal_homeostasis1.27567820
79MP0010094_abnormal_chromosome_stability1.26258516
80MP0001666_abnormal_nutrient_absorption1.25697228
81MP0003879_abnormal_hair_cell1.21319064
82MP0008872_abnormal_physiological_respon1.20637395
83MP0000372_irregular_coat_pigmentation1.20120904
84MP0005187_abnormal_penis_morphology1.19117971
85MP0000778_abnormal_nervous_system1.18383160
86MP0000749_muscle_degeneration1.17290724
87MP0002557_abnormal_social/conspecific_i1.15711333
88MP0004084_abnormal_cardiac_muscle1.15455954
89MP0010386_abnormal_urinary_bladder1.15241343
90MP0002938_white_spotting1.14053041
91MP0005409_darkened_coat_color1.12956116
92MP0001664_abnormal_digestion1.07032050
93MP0002066_abnormal_motor_capabilities/c1.06011286
94MP0005248_abnormal_Harderian_gland1.05671373
95MP0001661_extended_life_span1.05219670
96MP0003137_abnormal_impulse_conducting1.04043959
97MP0003786_premature_aging1.03263990
98MP0003252_abnormal_bile_duct1.01684203
99MP0000647_abnormal_sebaceous_gland1.01199368
100MP0003950_abnormal_plasma_membrane1.00733619
101MP0001963_abnormal_hearing_physiology0.99924473
102MP0005379_endocrine/exocrine_gland_phen0.99285741
103MP0004085_abnormal_heartbeat0.98573771
104MP0000358_abnormal_cell_content/0.98467704
105MP0000920_abnormal_myelination0.98364338
106MP0002254_reproductive_system_inflammat0.98010122
107MP0002876_abnormal_thyroid_physiology0.96739975
108MP0002882_abnormal_neuron_morphology0.96408117
109MP0001756_abnormal_urination0.96158280
110MP0005646_abnormal_pituitary_gland0.96067990
111MP0001485_abnormal_pinna_reflex0.96009649
112MP0002090_abnormal_vision0.94932525
113MP0002751_abnormal_autonomic_nervous0.92968818
114MP0009697_abnormal_copulation0.91461042
115MP0003693_abnormal_embryo_hatching0.91417814
116MP0002229_neurodegeneration0.90989265
117MP0005360_urolithiasis0.90212771
118MP0008569_lethality_at_weaning0.89671735
119MP0001727_abnormal_embryo_implantation0.87979312
120MP0000026_abnormal_inner_ear0.87632433
121MP0002972_abnormal_cardiac_muscle0.86062929
122MP0002752_abnormal_somatic_nervous0.85794725
123MP0004145_abnormal_muscle_electrophysio0.83963292
124MP0003567_abnormal_fetal_cardiomyocyte0.83518878
125MP0005535_abnormal_body_temperature0.81356372
126MP0000013_abnormal_adipose_tissue0.80422790
127MP0004043_abnormal_pH_regulation0.80073789
128MP0004381_abnormal_hair_follicle0.79567069
129MP0005620_abnormal_muscle_contractility0.78541866
130MP0005645_abnormal_hypothalamus_physiol0.77803987
131MP0006072_abnormal_retinal_apoptosis0.77605063
132MP0002118_abnormal_lipid_homeostasis0.76554804
133MP0008004_abnormal_stomach_pH0.75703317
134MP0003121_genomic_imprinting0.73654127
135MP0001502_abnormal_circadian_rhythm0.73376655
136MP0005330_cardiomyopathy0.73224973
137MP0003329_amyloid_beta_deposits0.70550103
138MP0008775_abnormal_heart_ventricle0.70069758
139MP0000955_abnormal_spinal_cord0.69934968
140MP0002102_abnormal_ear_morphology0.69559853
141MP0000230_abnormal_systemic_arterial0.69244380
142MP0005410_abnormal_fertilization0.68371392
143MP0004133_heterotaxia0.67846023
144MP0000631_abnormal_neuroendocrine_gland0.67587127
145MP0002909_abnormal_adrenal_gland0.67337122
146MP0010352_gastrointestinal_tract_polyps0.66795979
147MP0003119_abnormal_digestive_system0.66732600
148MP0000538_abnormal_urinary_bladder0.65966032
149MP0005253_abnormal_eye_physiology0.64425679
150MP0000762_abnormal_tongue_morphology0.64134164
151MP0000639_abnormal_adrenal_gland0.63536316
152MP0003111_abnormal_nucleus_morphology0.61189030
153MP0005670_abnormal_white_adipose0.59418393
154MP0005395_other_phenotype0.58128747
155MP0001544_abnormal_cardiovascular_syste0.57381647

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.36845943
2Abnormal mitochondria in muscle tissue (HP:0008316)6.73202488
3Mitochondrial inheritance (HP:0001427)6.32402935
4Progressive macrocephaly (HP:0004481)6.31896126
5Acute encephalopathy (HP:0006846)5.94624315
6Increased CSF lactate (HP:0002490)5.36411042
7Hepatocellular necrosis (HP:0001404)5.26739819
8Increased hepatocellular lipid droplets (HP:0006565)4.70530992
9Hepatic necrosis (HP:0002605)4.38462209
10Abnormality of glycolysis (HP:0004366)4.38171879
11Increased serum pyruvate (HP:0003542)4.38171879
12Lipid accumulation in hepatocytes (HP:0006561)4.15164773
13Cerebral edema (HP:0002181)4.09874992
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.08649388
15Focal motor seizures (HP:0011153)4.02695925
16Renal Fanconi syndrome (HP:0001994)4.02508743
17Optic disc pallor (HP:0000543)4.00992356
18Abnormality of aromatic amino acid family metabolism (HP:0004338)3.96012285
19Respiratory failure (HP:0002878)3.75744522
20Leukodystrophy (HP:0002415)3.73197137
21Exercise intolerance (HP:0003546)3.67066941
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.65184532
23Increased intramyocellular lipid droplets (HP:0012240)3.65136864
24Limb dystonia (HP:0002451)3.47339615
25Lactic acidosis (HP:0003128)3.46428827
26Pheochromocytoma (HP:0002666)3.40986114
27Myokymia (HP:0002411)3.31211156
28Hypoglycemic coma (HP:0001325)3.29198365
29Neuroendocrine neoplasm (HP:0100634)3.28772232
30Hyperglycinemia (HP:0002154)3.23914494
313-Methylglutaconic aciduria (HP:0003535)3.22142551
32Decreased activity of mitochondrial respiratory chain (HP:0008972)3.17871376
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.17871376
34Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.17851484
35Increased serum lactate (HP:0002151)3.13843917
36Increased muscle lipid content (HP:0009058)3.03627487
37Hypobetalipoproteinemia (HP:0003563)3.00410327
38Parakeratosis (HP:0001036)3.00347988
39Atonic seizures (HP:0010819)2.82066607
40Hypothermia (HP:0002045)2.77575075
41Abnormality of serum amino acid levels (HP:0003112)2.75389535
42Generalized aminoaciduria (HP:0002909)2.73332950
43Abnormality of serine family amino acid metabolism (HP:0010894)2.72761863
44Abnormality of glycine metabolism (HP:0010895)2.72761863
45Exertional dyspnea (HP:0002875)2.72376888
46Hyperglycinuria (HP:0003108)2.68912897
47X-linked dominant inheritance (HP:0001423)2.67754544
48Sensory axonal neuropathy (HP:0003390)2.63271266
49Respiratory difficulties (HP:0002880)2.62005085
50Intrahepatic cholestasis (HP:0001406)2.61528772
51Abnormality of methionine metabolism (HP:0010901)2.58146472
52Epileptic encephalopathy (HP:0200134)2.57154727
53Abnormality of renal resorption (HP:0011038)2.53059407
54Absence seizures (HP:0002121)2.45189965
55Abnormality of alanine metabolism (HP:0010916)2.43844748
56Hyperalaninemia (HP:0003348)2.43844748
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43844748
58Abnormal pupillary function (HP:0007686)2.43748322
59Neoplasm of the adrenal gland (HP:0100631)2.42873606
60Abnormality of vitamin B metabolism (HP:0004340)2.42759557
61Renal cortical cysts (HP:0000803)2.41993216
62Emotional lability (HP:0000712)2.41611371
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.41225892
64Abnormality of the anterior horn cell (HP:0006802)2.37854505
65Degeneration of anterior horn cells (HP:0002398)2.37854505
66Proximal tubulopathy (HP:0000114)2.36687208
67Irregular epiphyses (HP:0010582)2.30664065
68Abnormality of vitamin metabolism (HP:0100508)2.30234755
69Hyperventilation (HP:0002883)2.29976033
70Dialeptic seizures (HP:0011146)2.29076780
71Cholecystitis (HP:0001082)2.26930676
72Abnormal gallbladder physiology (HP:0012438)2.26930676
73Congenital ichthyosiform erythroderma (HP:0007431)2.24821631
74Prolonged partial thromboplastin time (HP:0003645)2.23810958
75CNS demyelination (HP:0007305)2.22070143
76Focal seizures (HP:0007359)2.19125413
77Abnormality of the labia minora (HP:0012880)2.17079915
78Hypoglycemic seizures (HP:0002173)2.12204803
79Medial flaring of the eyebrow (HP:0010747)2.11777637
80Gait imbalance (HP:0002141)2.09681529
81Hyperinsulinemic hypoglycemia (HP:0000825)2.03484804
82Intestinal atresia (HP:0011100)2.02751888
83Hyperphosphaturia (HP:0003109)2.01709954
84Muscle hypertrophy of the lower extremities (HP:0008968)2.01428840
85Abnormal hair whorl (HP:0010721)2.00829409
86Congenital primary aphakia (HP:0007707)2.00061535
87Hypoplasia of the fovea (HP:0007750)1.98601470
88Aplasia/Hypoplasia of the fovea (HP:0008060)1.98601470
89Hyperammonemia (HP:0001987)1.97410648
90Congenital malformation of the right heart (HP:0011723)1.97084186
91Double outlet right ventricle (HP:0001719)1.97084186
92Lethargy (HP:0001254)1.96516361
93Exercise-induced muscle cramps (HP:0003710)1.95691634
94Vaginal atresia (HP:0000148)1.95645603
95Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.94638672
96Degeneration of the lateral corticospinal tracts (HP:0002314)1.94638672
97Febrile seizures (HP:0002373)1.94598373
98Nausea (HP:0002018)1.94387499
99Cerebral hemorrhage (HP:0001342)1.93637487
100Sensorimotor neuropathy (HP:0007141)1.93375807
101Genital tract atresia (HP:0001827)1.92483225
102Conjunctival hamartoma (HP:0100780)1.92362182
103Visual hallucinations (HP:0002367)1.92285896
104Hypolipoproteinemia (HP:0010981)1.91976442
105Abnormality of placental membranes (HP:0011409)1.91613114
106Amniotic constriction ring (HP:0009775)1.91613114
107Epidermoid cyst (HP:0200040)1.91285053
108Poor suck (HP:0002033)1.89420050
109Progressive cerebellar ataxia (HP:0002073)1.88600217
110Pancreatic islet-cell hyperplasia (HP:0004510)1.88033741
111Abnormality of the fovea (HP:0000493)1.86537999
112Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.85220055
113Delusions (HP:0000746)1.84872296
114Generalized tonic-clonic seizures (HP:0002069)1.83171674
115Abnormality of the vitamin B12 metabolism (HP:0004341)1.82639882
116Acanthocytosis (HP:0001927)1.82517193
117Nephrogenic diabetes insipidus (HP:0009806)1.81770035
118Methylmalonic acidemia (HP:0002912)1.80769041
119Delayed gross motor development (HP:0002194)1.80322472
120Broad-based gait (HP:0002136)1.79229161
121Abnormality of cells of the erythroid lineage (HP:0012130)1.77435840
122Calf muscle hypertrophy (HP:0008981)1.76279704
123Abnormality of urine glucose concentration (HP:0011016)1.76174294
124Glycosuria (HP:0003076)1.76174294
125Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76151247
126Abnormal protein N-linked glycosylation (HP:0012347)1.76151247
127Abnormal protein glycosylation (HP:0012346)1.76151247
128Abnormal glycosylation (HP:0012345)1.76151247
129Hyperglycemia (HP:0003074)1.75895770
130Sudden death (HP:0001699)1.74562974
131Symptomatic seizures (HP:0011145)1.74271902
132Dicarboxylic aciduria (HP:0003215)1.73745250
133Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73745250
134Fat malabsorption (HP:0002630)1.73519482
135Metabolic acidosis (HP:0001942)1.72788087
136Anxiety (HP:0000739)1.71173729
137Postnatal microcephaly (HP:0005484)1.71014602
138Progressive inability to walk (HP:0002505)1.70902338
139Abnormality of monocarboxylic acid metabolism (HP:0010996)1.70290901
140Esotropia (HP:0000565)1.69327845
141Steatorrhea (HP:0002570)1.68993528
142Palpitations (HP:0001962)1.68728967
143Polyphagia (HP:0002591)1.64578745
144Blindness (HP:0000618)1.64469722
145Abnormality of fatty-acid metabolism (HP:0004359)1.63143122
146Abnormal gallbladder morphology (HP:0012437)1.62043304
147Abnormal urine phosphate concentration (HP:0012599)1.60644483
148Hypoplastic left heart (HP:0004383)1.58967824
149Myotonia (HP:0002486)1.58510907
150Methylmalonic aciduria (HP:0012120)1.56489042
151Abnormality of the calf musculature (HP:0001430)1.55719739
152Short tibia (HP:0005736)1.52689514
153Gliosis (HP:0002171)1.51472816
154Aplasia/Hypoplasia of the tibia (HP:0005772)1.51043742
155Progressive external ophthalmoplegia (HP:0000590)1.49448326
156Cerebral hypomyelination (HP:0006808)1.49239796
157Diminished movement (HP:0002374)1.49171821

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.06101316
2CASK4.05353139
3NEK13.26383086
4TRIM282.93350181
5NME12.93295535
6EIF2AK32.65140141
7STK392.50338018
8MAP2K72.28589497
9MYLK2.19762998
10ERBB32.12679068
11OXSR12.09778305
12GRK52.03935702
13ARAF2.01879605
14LIMK11.96471966
15PBK1.94660815
16MST41.94306403
17GRK71.94107319
18MAP3K41.90665700
19PLK21.89548957
20CDK191.89056181
21PLK31.88936443
22STK161.84325094
23MAP4K21.78935015
24FRK1.77278573
25PNCK1.72229965
26MAPKAPK51.66645716
27BCR1.62353622
28ACVR1B1.62148582
29SRPK11.60511494
30MKNK21.60292927
31WNK41.55199813
32EPHA41.55154180
33TNIK1.53684795
34NTRK31.48541783
35OBSCN1.46180713
36ADRBK21.44445451
37TTK1.42103684
38PLK41.39794526
39NUAK11.33298901
40BRSK21.32523827
41BRAF1.25635976
42CAMK2B1.23786928
43MUSK1.23360489
44CAMK2A1.23028962
45CAMK2D1.22269673
46MKNK11.21257975
47MAP2K41.21018465
48NME21.20717956
49MINK11.20653385
50ZAK1.20002419
51WEE11.19945349
52FER1.17137261
53MARK11.16584719
54CSNK1A1L1.11285597
55PINK11.09622605
56MST1R1.08479319
57CSNK1G31.06188896
58GRK11.06066921
59BMPR21.05456279
60TLK11.05363410
61PRPF4B1.02365927
62PIK3CA1.02285568
63PDK30.97764141
64PDK40.97764141
65LMTK20.95399091
66PLK10.94491652
67FGR0.92066300
68CAMK2G0.91907729
69PTK2B0.90873899
70STK240.90611713
71ADRBK10.90111001
72BMPR1B0.88783168
73WNK30.88717481
74VRK20.87457236
75PHKG20.87077310
76PHKG10.87077310
77TSSK60.86221363
78PRKCE0.86157978
79ROCK20.84835258
80DAPK30.83436163
81PRKCG0.80692775
82CDK140.79931616
83CSNK1G20.79211798
84MAPK130.78876735
85PAK40.78469112
86RIPK40.78066370
87STK30.78028661
88BRSK10.77847043
89UHMK10.77081132
90PDK20.76746969
91DYRK20.76488770
92PKN10.75284842
93EIF2AK20.73529524
94CDK180.73522589
95CDK50.73494488
96AKT30.71723342
97BUB10.71662632
98CDK150.68507310
99PIM20.67604403
100TESK10.63035050
101EIF2AK10.63025593
102CDK11A0.62487118
103ERBB40.61150889
104PRKACA0.59158822
105MAP3K90.58569184
106PAK30.58281948
107INSRR0.57770685
108ABL20.57291738
109NTRK20.56862882
110SIK30.56440632
111CSNK1G10.53357765
112BCKDK0.52785957
113CDK80.52483584
114CDK30.51773358
115CCNB10.50330873
116VRK10.49945353
117FGFR10.48512524
118NTRK10.48495574
119PRKCI0.48172666
120DAPK10.46705875
121ROCK10.46663061
122DAPK20.45923243
123EPHB20.45851166
124MAP3K110.44469735
125STK38L0.42701497
126DYRK1A0.42384489
127CSNK1E0.40218473
128PAK60.39829073
129IRAK20.39673931
130NEK60.38429351
131TAF10.38421192
132ILK0.37155832
133CDC70.36773756
134CSNK2A10.36198647
135SGK4940.35964105
136SGK2230.35964105
137PRKG10.35447269
138CSNK1A10.35346677
139SCYL20.34852320
140FGFR20.32933547
141STK40.32615867
142MAP3K50.30915447

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001906.46294839
2Parkinsons disease_Homo sapiens_hsa050125.41055427
3Alzheimers disease_Homo sapiens_hsa050104.14339626
4Huntingtons disease_Homo sapiens_hsa050163.69705060
5Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.23202888
6Cardiac muscle contraction_Homo sapiens_hsa042603.02688009
7Collecting duct acid secretion_Homo sapiens_hsa049662.77887476
8Proteasome_Homo sapiens_hsa030502.55315596
9Ribosome_Homo sapiens_hsa030102.49720261
10Nicotine addiction_Homo sapiens_hsa050332.26118132
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19864067
12Synaptic vesicle cycle_Homo sapiens_hsa047212.18494766
13Vitamin B6 metabolism_Homo sapiens_hsa007502.10219816
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.88766052
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.83294817
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.80007717
17Fatty acid elongation_Homo sapiens_hsa000621.79858023
18Vibrio cholerae infection_Homo sapiens_hsa051101.78483627
19Sulfur metabolism_Homo sapiens_hsa009201.74083390
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.71436255
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.61498470
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59422803
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.59032860
24Fatty acid degradation_Homo sapiens_hsa000711.52770125
25Folate biosynthesis_Homo sapiens_hsa007901.50690312
26Caffeine metabolism_Homo sapiens_hsa002321.50663523
27Protein export_Homo sapiens_hsa030601.50455198
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.49935228
29RNA polymerase_Homo sapiens_hsa030201.42388930
30Fatty acid metabolism_Homo sapiens_hsa012121.42137778
31Peroxisome_Homo sapiens_hsa041461.40218719
32Arginine biosynthesis_Homo sapiens_hsa002201.38852597
33Nitrogen metabolism_Homo sapiens_hsa009101.36278054
34Retinol metabolism_Homo sapiens_hsa008301.34442087
35GABAergic synapse_Homo sapiens_hsa047271.32027044
36Mismatch repair_Homo sapiens_hsa034301.31107526
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30580241
38Serotonergic synapse_Homo sapiens_hsa047261.29632536
39Pyruvate metabolism_Homo sapiens_hsa006201.28976855
40Rheumatoid arthritis_Homo sapiens_hsa053231.16911350
41One carbon pool by folate_Homo sapiens_hsa006701.14809682
42Non-homologous end-joining_Homo sapiens_hsa034501.11863295
43Tryptophan metabolism_Homo sapiens_hsa003801.09859300
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08782851
45Morphine addiction_Homo sapiens_hsa050321.08544368
46beta-Alanine metabolism_Homo sapiens_hsa004101.07882782
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06218363
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03611353
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02085900
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01658506
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.00126895
52Tyrosine metabolism_Homo sapiens_hsa003500.99313848
53Amphetamine addiction_Homo sapiens_hsa050310.99000088
54Fat digestion and absorption_Homo sapiens_hsa049750.98071585
55Dopaminergic synapse_Homo sapiens_hsa047280.97464803
56Biosynthesis of amino acids_Homo sapiens_hsa012300.96529183
57Circadian entrainment_Homo sapiens_hsa047130.95634161
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.93491462
59Steroid biosynthesis_Homo sapiens_hsa001000.91392466
60Taste transduction_Homo sapiens_hsa047420.90509243
61Butanoate metabolism_Homo sapiens_hsa006500.89863819
62Glutamatergic synapse_Homo sapiens_hsa047240.89349788
63Phenylalanine metabolism_Homo sapiens_hsa003600.86767970
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86180629
65Long-term depression_Homo sapiens_hsa047300.85618686
66Phototransduction_Homo sapiens_hsa047440.85535964
67Propanoate metabolism_Homo sapiens_hsa006400.83605579
68Olfactory transduction_Homo sapiens_hsa047400.81867149
69Cocaine addiction_Homo sapiens_hsa050300.80679429
70Salivary secretion_Homo sapiens_hsa049700.76031154
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.75124763
72Metabolic pathways_Homo sapiens_hsa011000.74196828
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72500715
74PPAR signaling pathway_Homo sapiens_hsa033200.70866520
75Homologous recombination_Homo sapiens_hsa034400.70859996
76Selenocompound metabolism_Homo sapiens_hsa004500.69986007
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68482939
78Calcium signaling pathway_Homo sapiens_hsa040200.67363708
79Carbon metabolism_Homo sapiens_hsa012000.67169638
80Ether lipid metabolism_Homo sapiens_hsa005650.67106508
81Starch and sucrose metabolism_Homo sapiens_hsa005000.65723596
82Phagosome_Homo sapiens_hsa041450.65530526
83Long-term potentiation_Homo sapiens_hsa047200.63532167
84Renin secretion_Homo sapiens_hsa049240.62563387
85Cholinergic synapse_Homo sapiens_hsa047250.62028254
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61887899
87Circadian rhythm_Homo sapiens_hsa047100.61170759
88Oocyte meiosis_Homo sapiens_hsa041140.59994265
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59023153
90Nucleotide excision repair_Homo sapiens_hsa034200.56171424
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56030303
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55738602
93RNA degradation_Homo sapiens_hsa030180.54898773
94Complement and coagulation cascades_Homo sapiens_hsa046100.54859780
95RNA transport_Homo sapiens_hsa030130.51045356
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48667752
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48252937
98DNA replication_Homo sapiens_hsa030300.46850728
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45106508
100Axon guidance_Homo sapiens_hsa043600.44898294
101Fanconi anemia pathway_Homo sapiens_hsa034600.43509650
102Sphingolipid metabolism_Homo sapiens_hsa006000.43473699
103Gastric acid secretion_Homo sapiens_hsa049710.43343350
104Linoleic acid metabolism_Homo sapiens_hsa005910.43245038
105Arachidonic acid metabolism_Homo sapiens_hsa005900.42005471
106Oxytocin signaling pathway_Homo sapiens_hsa049210.40438140
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39175709
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.38621150
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38540316
110Gap junction_Homo sapiens_hsa045400.38375196
111Bile secretion_Homo sapiens_hsa049760.38082338
112Insulin secretion_Homo sapiens_hsa049110.37982293
113Histidine metabolism_Homo sapiens_hsa003400.37485112
114Pyrimidine metabolism_Homo sapiens_hsa002400.35320984
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35279716
116Dilated cardiomyopathy_Homo sapiens_hsa054140.35115352
117Purine metabolism_Homo sapiens_hsa002300.34064889
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33960281
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33586895
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32953795
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32676217
122Type I diabetes mellitus_Homo sapiens_hsa049400.32462581
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32024733
124Glutathione metabolism_Homo sapiens_hsa004800.31387630
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30684065
126Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30171784
127N-Glycan biosynthesis_Homo sapiens_hsa005100.29802136
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29672477
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.28720379
130Regulation of autophagy_Homo sapiens_hsa041400.28373281
131Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28357962
132Mineral absorption_Homo sapiens_hsa049780.27952356
133Fructose and mannose metabolism_Homo sapiens_hsa000510.25393920
134Alcoholism_Homo sapiens_hsa050340.24137936
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24051993
136Basal transcription factors_Homo sapiens_hsa030220.22100318
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20509983
138GnRH signaling pathway_Homo sapiens_hsa049120.20180904
139Arginine and proline metabolism_Homo sapiens_hsa003300.19682008
140Autoimmune thyroid disease_Homo sapiens_hsa053200.19000281
141African trypanosomiasis_Homo sapiens_hsa051430.18833062
142Pancreatic secretion_Homo sapiens_hsa049720.18531960
143Chemical carcinogenesis_Homo sapiens_hsa052040.18242940
144Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.16421662
145Graft-versus-host disease_Homo sapiens_hsa053320.13915119
146Melanogenesis_Homo sapiens_hsa049160.12704183

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