HIGD1AP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of activation of Janus kinase activity (GO:0010533)9.13463498
2growth hormone receptor signaling pathway (GO:0060396)6.69867150
3maturation of SSU-rRNA (GO:0030490)6.64485542
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.99658051
5ATP synthesis coupled proton transport (GO:0015986)5.99658051
6chaperone-mediated protein transport (GO:0072321)5.98856903
7cellular response to growth hormone stimulus (GO:0071378)5.94358542
8viral transcription (GO:0019083)5.40374513
9ribosomal small subunit assembly (GO:0000028)5.19066474
10positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)5.11993573
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.10098374
12hypothalamus development (GO:0021854)5.09217481
13translational termination (GO:0006415)5.03729964
14cell proliferation in forebrain (GO:0021846)4.79374526
15embryonic retina morphogenesis in camera-type eye (GO:0060059)4.66437666
16regulation of odontogenesis of dentin-containing tooth (GO:0042487)4.46766566
17sequestering of actin monomers (GO:0042989)4.41417201
18positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.39521341
19regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.36914219
20regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.36914219
21translational elongation (GO:0006414)4.36224126
22positive regulation of T cell apoptotic process (GO:0070234)4.25731761
23T-helper 1 type immune response (GO:0042088)4.25413005
24dendritic spine morphogenesis (GO:0060997)4.24435048
25endoderm formation (GO:0001706)4.16627640
26cotranslational protein targeting to membrane (GO:0006613)4.12993679
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.12531032
28viral life cycle (GO:0019058)4.12456962
29protein targeting to ER (GO:0045047)4.09688487
30regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)4.04506520
31L-serine metabolic process (GO:0006563)3.95089114
32establishment of protein localization to endoplasmic reticulum (GO:0072599)3.92170744
33protein neddylation (GO:0045116)3.89003567
34pyrimidine ribonucleoside catabolic process (GO:0046133)3.84814913
35cellular protein complex disassembly (GO:0043624)3.79527796
36protein localization to endoplasmic reticulum (GO:0070972)3.75060293
37DNA deamination (GO:0045006)3.71446500
38nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.69139286
39ribosomal small subunit biogenesis (GO:0042274)3.63037980
40kinetochore assembly (GO:0051382)3.61103257
41positive regulation of respiratory burst (GO:0060267)3.60513888
42head development (GO:0060322)3.59563146
43somite development (GO:0061053)3.59533619
44GTP biosynthetic process (GO:0006183)3.57530385
45cerebral cortex neuron differentiation (GO:0021895)3.57066174
46regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.54503042
47regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.49716352
48thalamus development (GO:0021794)3.47907891
49kinetochore organization (GO:0051383)3.47858921
50respiratory electron transport chain (GO:0022904)3.46506344
51electron transport chain (GO:0022900)3.42524586
52mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.41312451
53purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.35220385
54behavioral response to nicotine (GO:0035095)3.34677954
55regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.32112941
56ATP biosynthetic process (GO:0006754)3.28175122
57positive regulation of lymphocyte apoptotic process (GO:0070230)3.26327710
58purine nucleoside triphosphate biosynthetic process (GO:0009145)3.26041242
59regulation of neurotransmitter uptake (GO:0051580)3.24914856
60protein complex disassembly (GO:0043241)3.24182801
61regulation of posttranscriptional gene silencing (GO:0060147)3.21602963
62regulation of gene silencing by miRNA (GO:0060964)3.21602963
63regulation of gene silencing by RNA (GO:0060966)3.21602963
64auditory behavior (GO:0031223)3.19246167
65dentate gyrus development (GO:0021542)3.13724279
66positive regulation of receptor internalization (GO:0002092)3.13334617
67pattern specification involved in kidney development (GO:0061004)3.12939588
68establishment of protein localization to mitochondrial membrane (GO:0090151)3.07202315
69transmission of nerve impulse (GO:0019226)3.04758947
70mechanosensory behavior (GO:0007638)3.02698804
71response to growth hormone (GO:0060416)3.02465050
72macromolecular complex disassembly (GO:0032984)3.01246751
73telencephalon development (GO:0021537)3.00339856
74neuronal stem cell maintenance (GO:0097150)2.98511407
75UTP biosynthetic process (GO:0006228)2.98176317
76negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.97282868
77translational initiation (GO:0006413)2.96653585
78response to xenobiotic stimulus (GO:0009410)2.93622922
79negative regulation of cytosolic calcium ion concentration (GO:0051481)2.89952223
80regulation of somitogenesis (GO:0014807)2.89423738
81hydrogen ion transmembrane transport (GO:1902600)2.88229819
82anatomical structure maturation (GO:0071695)2.86251393
83protein targeting to membrane (GO:0006612)2.85291606
84guanosine-containing compound biosynthetic process (GO:1901070)2.78947549
85detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.77917169
86ribonucleoside triphosphate biosynthetic process (GO:0009201)2.77390469
87cornea development in camera-type eye (GO:0061303)2.75606521
88urate metabolic process (GO:0046415)2.72341423
89protein deneddylation (GO:0000338)2.70573291
90UTP metabolic process (GO:0046051)2.70268157
91killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.68701924
92disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.68701924
93response to host immune response (GO:0052572)2.67292861
94response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.67292861
95positive regulation by symbiont of host defense response (GO:0052509)2.67078681
96modulation by symbiont of host defense response (GO:0052031)2.67078681
97modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.67078681
98modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.67078681
99positive regulation by organism of defense response of other organism involved in symbiotic interact2.67078681
100modulation by symbiont of host immune response (GO:0052553)2.67078681

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.70014015
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.10133799
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.44485178
4EED_16625203_ChIP-ChIP_MESCs_Mouse2.68650849
5RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.59333947
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.49413322
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.47396336
8PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.44579346
9POU5F1_16153702_ChIP-ChIP_HESCs_Human2.33852762
10SRY_22984422_ChIP-ChIP_TESTIS_Rat2.28270671
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.22465392
12EZH2_27294783_Chip-Seq_ESCs_Mouse2.20612694
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.20382679
14KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.13222342
15SOX2_16153702_ChIP-ChIP_HESCs_Human2.09286311
16SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01292843
17MYC_18940864_ChIP-ChIP_HL60_Human2.00652763
18JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99720777
19TP53_20018659_ChIP-ChIP_R1E_Mouse1.93217859
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91187321
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.85767563
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75426605
23RNF2_27304074_Chip-Seq_NSC_Mouse1.75071324
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74771836
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.71172978
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.62942544
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.61647562
28SOX2_18555785_ChIP-Seq_MESCs_Mouse1.61614617
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58199307
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58199307
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57578261
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56847834
33GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.56544606
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56363272
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.55577684
36BCL6_27268052_Chip-Seq_Bcells_Human1.55457231
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50617467
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.43058884
39CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42565566
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40140034
41ELK1_19687146_ChIP-ChIP_HELA_Human1.39822343
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38312626
43IRF1_19129219_ChIP-ChIP_H3396_Human1.32228721
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31445391
45STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.30042707
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24417969
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24388179
48RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.24048051
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.22929373
50VDR_22108803_ChIP-Seq_LS180_Human1.20418880
51NANOG_16153702_ChIP-ChIP_HESCs_Human1.17541745
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.16325712
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16273405
54EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16114775
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.14924991
56VDR_23849224_ChIP-Seq_CD4+_Human1.14828314
57REST_21632747_ChIP-Seq_MESCs_Mouse1.12858868
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12542564
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11925413
60CTCF_27219007_Chip-Seq_Bcells_Human1.11078447
61TDRD3_21172665_ChIP-Seq_MCF-7_Human1.11040675
62E2F4_17652178_ChIP-ChIP_JURKAT_Human1.10608932
63AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07434623
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06928639
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06198325
66SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04735738
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.02923896
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02371366
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.02371366
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01913859
71XRN2_22483619_ChIP-Seq_HELA_Human1.01571281
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.00840756
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99758485
74YY1_22570637_ChIP-Seq_MALME-3M_Human0.99004069
75GATA3_21878914_ChIP-Seq_MCF-7_Human0.96759270
76STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.93542930
77CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91653753
78ERA_21632823_ChIP-Seq_H3396_Human0.91439295
79TP53_22573176_ChIP-Seq_HFKS_Human0.91203331
80P68_20966046_ChIP-Seq_HELA_Human0.90762819
81SOX2_22085726_ChIP-Seq_NPCs_Mouse0.90594429
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89912582
83CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88861027
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88850524
85HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.88517663
86E2F1_17053090_ChIP-ChIP_MCF-7_Human0.87308487
87TTF2_22483619_ChIP-Seq_HELA_Human0.85766622
88TP53_22127205_ChIP-Seq_IMR90_Human0.85376681
89WDR5_24793694_ChIP-Seq_LNCAP_Human0.85089864
90SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84907988
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.84489521
92AR_21572438_ChIP-Seq_LNCaP_Human0.83917319
93SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.83805224
94HTT_18923047_ChIP-ChIP_STHdh_Human0.83712171
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83639861
96EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83468922
97LXR_22292898_ChIP-Seq_THP-1_Human0.83386825
98ELK4_26923725_Chip-Seq_MESODERM_Mouse0.82305321
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81988495
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.81465542

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode6.91351859
2MP0009379_abnormal_foot_pigmentation5.63363449
3MP0000778_abnormal_nervous_system2.77840138
4MP0002163_abnormal_gland_morphology2.70700690
5MP0003283_abnormal_digestive_organ2.70556944
6MP0001529_abnormal_vocalization2.67235129
7MP0003011_delayed_dark_adaptation2.62763162
8MP0000631_abnormal_neuroendocrine_gland2.50189399
9MP0005645_abnormal_hypothalamus_physiol2.45817986
10MP0000049_abnormal_middle_ear2.34976779
11MP0001293_anophthalmia2.21179007
12MP0004885_abnormal_endolymph2.18629277
13MP0003879_abnormal_hair_cell2.14496913
14MP0002638_abnormal_pupillary_reflex2.06422098
15MP0006072_abnormal_retinal_apoptosis1.98056103
16MP0001286_abnormal_eye_development1.90146281
17MP0001905_abnormal_dopamine_level1.72343608
18MP0009046_muscle_twitch1.72236691
19MP0004147_increased_porphyrin_level1.70613361
20MP0002822_catalepsy1.69200169
21MP0002653_abnormal_ependyma_morphology1.66061184
22MP0000678_abnormal_parathyroid_gland1.63927265
23MP0000026_abnormal_inner_ear1.58975480
24MP0005671_abnormal_response_to1.57295283
25MP0005379_endocrine/exocrine_gland_phen1.54392492
26MP0001485_abnormal_pinna_reflex1.50632358
27MP0002282_abnormal_trachea_morphology1.42058104
28MP0003136_yellow_coat_color1.41233409
29MP0004142_abnormal_muscle_tone1.39081898
30MP0005646_abnormal_pituitary_gland1.36463032
31MP0002184_abnormal_innervation1.33609433
32MP0003938_abnormal_ear_development1.31258841
33MP0008789_abnormal_olfactory_epithelium1.31110137
34MP0002160_abnormal_reproductive_system1.29284723
35MP0002557_abnormal_social/conspecific_i1.27836284
36MP0001963_abnormal_hearing_physiology1.26450864
37MP0006276_abnormal_autonomic_nervous1.26361735
38MP0000566_synostosis1.25339187
39MP0002249_abnormal_larynx_morphology1.21326690
40MP0009053_abnormal_anal_canal1.20490671
41MP0005195_abnormal_posterior_eye1.18328000
42MP0002752_abnormal_somatic_nervous1.17973630
43MP0002928_abnormal_bile_duct1.17274794
44MP0000955_abnormal_spinal_cord1.16395043
45MP0005499_abnormal_olfactory_system1.15608880
46MP0005394_taste/olfaction_phenotype1.15608880
47MP0005386_behavior/neurological_phenoty1.14928431
48MP0004924_abnormal_behavior1.14928431
49MP0005423_abnormal_somatic_nervous1.13563516
50MP0001502_abnormal_circadian_rhythm1.10030799
51MP0002095_abnormal_skin_pigmentation1.09016040
52MP0005084_abnormal_gallbladder_morpholo1.08528676
53MP0002272_abnormal_nervous_system1.05732699
54MP0005083_abnormal_biliary_tract1.04374812
55MP0005451_abnormal_body_composition1.03455679
56MP0004130_abnormal_muscle_cell1.01582796
57MP0003787_abnormal_imprinting1.01473799
58MP0005253_abnormal_eye_physiology1.01378006
59MP0002234_abnormal_pharynx_morphology0.97751535
60MP0003942_abnormal_urinary_system0.96870926
61MP0000428_abnormal_craniofacial_morphol0.95720994
62MP0009745_abnormal_behavioral_response0.94078953
63MP0003880_abnormal_central_pattern0.92840494
64MP0000613_abnormal_salivary_gland0.91820612
65MP0005389_reproductive_system_phenotype0.90651811
66MP0005391_vision/eye_phenotype0.85289370
67MP0001542_abnormal_bone_strength0.84905989
68MP0004742_abnormal_vestibular_system0.84523138
69MP0002723_abnormal_immune_serum0.82815927
70MP0002063_abnormal_learning/memory/cond0.82349600
71MP0002132_abnormal_respiratory_system0.81859971
72MP0002697_abnormal_eye_size0.81329085
73MP0003755_abnormal_palate_morphology0.80848704
74MP0003635_abnormal_synaptic_transmissio0.77020158
75MP0008995_early_reproductive_senescence0.75700905
76MP0009250_abnormal_appendicular_skeleto0.75450847
77MP0002116_abnormal_craniofacial_bone0.74578015
78MP0005551_abnormal_eye_electrophysiolog0.73762679
79MP0002882_abnormal_neuron_morphology0.72225877
80MP0003195_calcinosis0.71894054
81MP0001727_abnormal_embryo_implantation0.71837999
82MP0003937_abnormal_limbs/digits/tail_de0.71822329
83MP0002152_abnormal_brain_morphology0.71385289
84MP0002876_abnormal_thyroid_physiology0.70699377
85MP0001800_abnormal_humoral_immune0.68991429
86MP0008872_abnormal_physiological_respon0.68036656
87MP0003122_maternal_imprinting0.65823255
88MP0002210_abnormal_sex_determination0.65668244
89MP0008875_abnormal_xenobiotic_pharmacok0.65593490
90MP0006036_abnormal_mitochondrial_physio0.65116791
91MP0005448_abnormal_energy_balance0.64943419
92MP0002136_abnormal_kidney_physiology0.64848330
93MP0002138_abnormal_hepatobiliary_system0.64839455
94MP0003123_paternal_imprinting0.64672728
95MP0001188_hyperpigmentation0.64625439
96MP0006035_abnormal_mitochondrial_morpho0.64009270
97MP0002233_abnormal_nose_morphology0.63582497
98MP0001324_abnormal_eye_pigmentation0.63470621
99MP0003861_abnormal_nervous_system0.62023426
100MP0002909_abnormal_adrenal_gland0.61617589

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)5.25016449
2Reticulocytopenia (HP:0001896)5.17832305
33-Methylglutaconic aciduria (HP:0003535)4.17988930
4Acute necrotizing encephalopathy (HP:0006965)4.01652270
5Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.94497037
6Growth hormone deficiency (HP:0000824)3.80531306
7Abnormal mitochondria in muscle tissue (HP:0008316)3.79052706
8Anophthalmia (HP:0000528)3.60848676
9Papilledema (HP:0001085)3.46822992
10Mitochondrial inheritance (HP:0001427)3.38178282
11Progressive macrocephaly (HP:0004481)3.37711546
12Optic nerve hypoplasia (HP:0000609)3.25832248
13Macrocytic anemia (HP:0001972)3.16027268
14Shawl scrotum (HP:0000049)3.06897133
15Hepatocellular necrosis (HP:0001404)3.04566357
16Deep palmar crease (HP:0006191)3.02381071
17Absent septum pellucidum (HP:0001331)3.01461988
18Morphological abnormality of the middle ear (HP:0008609)2.95446852
19Abnormality of the nasal septum (HP:0000419)2.89949441
20Acute encephalopathy (HP:0006846)2.89592013
21Lipid accumulation in hepatocytes (HP:0006561)2.82562148
22Lissencephaly (HP:0001339)2.81826887
23Sclerocornea (HP:0000647)2.76634100
24Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.69582799
25Increased CSF lactate (HP:0002490)2.66572546
26Pancreatic fibrosis (HP:0100732)2.62425781
27Partial agenesis of the corpus callosum (HP:0001338)2.54926996
28Pallor (HP:0000980)2.54138415
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.45092624
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.42018853
31Maternal diabetes (HP:0009800)2.41407904
32Absent thumb (HP:0009777)2.39874094
33Increased hepatocellular lipid droplets (HP:0006565)2.37315740
34Pancreatic cysts (HP:0001737)2.37086040
35Abnormality of the septum pellucidum (HP:0007375)2.34986858
36Colon cancer (HP:0003003)2.33444558
37Increased intramyocellular lipid droplets (HP:0012240)2.33378807
38Cortical visual impairment (HP:0100704)2.30910594
39Gastrointestinal stroma tumor (HP:0100723)2.30037210
40Morphological abnormality of the inner ear (HP:0011390)2.27305737
41Rhabdomyosarcoma (HP:0002859)2.26264157
42Increased muscle lipid content (HP:0009058)2.25574322
43Congenital stationary night blindness (HP:0007642)2.23720037
44Aplasia/Hypoplasia of the spleen (HP:0010451)2.23600633
45Abnormality of cells of the erythroid lineage (HP:0012130)2.23146338
46Hepatic necrosis (HP:0002605)2.22589251
47Abnormality of purine metabolism (HP:0004352)2.21142545
48Type II lissencephaly (HP:0007260)2.18529343
49Abnormality of the proximal phalanges of the hand (HP:0009834)2.17409200
50Bilateral microphthalmos (HP:0007633)2.16420290
51Hypoplasia of the uterus (HP:0000013)2.15388164
52Enlarged kidneys (HP:0000105)2.14625840
53Abnormality of the prostate (HP:0008775)2.14061649
54Symphalangism affecting the phalanges of the hand (HP:0009773)2.13839089
55Cerebral edema (HP:0002181)2.12809197
56Agitation (HP:0000713)2.09877977
57Humeroradial synostosis (HP:0003041)2.09480703
58Synostosis involving the elbow (HP:0003938)2.09480703
59Long nose (HP:0003189)2.02846124
60Irregular vertebral endplates (HP:0003301)1.99551518
61Breast hypoplasia (HP:0003187)1.99277457
62Aplasia/Hypoplasia of the nipples (HP:0006709)1.97208096
63Aplasia/Hypoplasia of the patella (HP:0006498)1.95816473
64Pendular nystagmus (HP:0012043)1.93797370
65True hermaphroditism (HP:0010459)1.91687940
66Severe short stature (HP:0003510)1.89461763
67Abnormality of the vertebral endplates (HP:0005106)1.89303542
68Thyroid-stimulating hormone excess (HP:0002925)1.88648747
69Abnormal rod and cone electroretinograms (HP:0008323)1.88541537
70Abnormal pancreas size (HP:0012094)1.87032240
71Hypoplasia of the brainstem (HP:0002365)1.83393546
72Aplasia/Hypoplasia of the brainstem (HP:0007362)1.83393546
73Optic disc pallor (HP:0000543)1.82616650
74Anterior segment dysgenesis (HP:0007700)1.82017871
75Hypoplastic pelvis (HP:0008839)1.80650238
76Aplasia/hypoplasia of the uterus (HP:0008684)1.79475240
77Midline defect of the nose (HP:0004122)1.79407520
78Trigonocephaly (HP:0000243)1.78824097
79Abnormal number of erythroid precursors (HP:0012131)1.78733321
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.77826488
81Hepatoblastoma (HP:0002884)1.76876189
82Stenosis of the external auditory canal (HP:0000402)1.76642108
83Turricephaly (HP:0000262)1.74513856
84Testicular atrophy (HP:0000029)1.73818375
85Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.72921715
86Neoplasm of striated muscle (HP:0009728)1.72772916
87Palpebral edema (HP:0100540)1.72710625
88Patellar aplasia (HP:0006443)1.70463697
89Asplenia (HP:0001746)1.69938932
90Abnormality of the phalanges of the 5th finger (HP:0004213)1.68661379
91Microvesicular hepatic steatosis (HP:0001414)1.68344088
92Dandy-Walker malformation (HP:0001305)1.67350449
93Lymphopenia (HP:0001888)1.65004948
94Oligodactyly (hands) (HP:0001180)1.64883343
95Increased serum lactate (HP:0002151)1.64555241
96Pachygyria (HP:0001302)1.64124694
97Abnormality of nucleobase metabolism (HP:0010932)1.63170803
98Flat capital femoral epiphysis (HP:0003370)1.62646445
99Synostosis of carpal bones (HP:0005048)1.62269814
100Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.62085578

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.70822644
2VRK13.72495921
3VRK23.46487311
4SMG13.20368750
5TLK13.07270045
6ZAK2.95460185
7SIK22.89407775
8CDK192.57195539
9BLK2.51115028
10MAP3K112.32768786
11CDC72.25826788
12DYRK1B2.15151714
13NTRK22.04801542
14OXSR12.00119577
15MAP4K11.86059452
16PIK3CG1.64628047
17WNK41.50558631
18IRAK41.46524930
19MAP4K21.46148322
20RPS6KA51.43017415
21FRK1.40569459
22ERBB21.31087847
23UHMK11.29869739
24AURKA1.28631551
25PLK21.24737449
26CAMK11.23016465
27BRAF1.22525744
28STK161.22049243
29CHEK21.16454264
30EPHA41.14822194
31TAF11.12987246
32STK41.12601115
33RPS6KA41.11550567
34DAPK31.09655564
35GRK11.07131941
36ARAF1.06646054
37PKN11.05065460
38ADRBK20.96914857
39AURKB0.90321554
40CAMKK20.88654004
41PLK30.87537405
42TEC0.86110572
43PRKCZ0.86056959
44STK110.85212075
45CAMK40.85074014
46CASK0.82541861
47MARK20.82509085
48MAP3K90.81497539
49WNK30.78936516
50INSRR0.78785845
51GRK60.77780542
52SYK0.77170578
53BTK0.71273760
54MOS0.69595150
55CDK140.69317793
56RPS6KA60.68062697
57MARK10.66984397
58PIK3CA0.65954898
59RPS6KA20.65177753
60PRKCQ0.64547339
61NUAK10.64520703
62PAK30.64427513
63PRKD20.64335503
64RPS6KC10.62568638
65RPS6KL10.62568638
66JAK30.62389904
67CDK150.61927355
68PIM10.61860887
69SGK20.61166545
70DYRK20.58862944
71MAPK150.54859496
72ITK0.53281437
73NME10.53242560
74INSR0.52033185
75CDK180.51231858
76CSNK2A20.50883059
77MAPK130.48986143
78IKBKB0.48269853
79STK390.47606009
80CDK11A0.46746495
81MAPKAPK50.46161298
82HIPK20.45658456
83BRSK20.43550727
84MAP3K10.43449726
85PAK10.43012274
86PRKCD0.42553687
87NTRK10.41302621
88MAP2K20.40741784
89PAK60.40538304
90BCKDK0.39185258
91PRKACA0.38210719
92CSK0.37356472
93LCK0.36576157
94NEK10.35743157
95KIT0.34775001
96MATK0.34304173
97LYN0.33027676
98SGK2230.32209978
99SGK4940.32209978
100WNK10.31869796

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.63408995
2Oxidative phosphorylation_Homo sapiens_hsa001904.49113677
3Parkinsons disease_Homo sapiens_hsa050124.04310326
4Systemic lupus erythematosus_Homo sapiens_hsa053223.82992725
5Cardiac muscle contraction_Homo sapiens_hsa042603.33058429
6Sulfur relay system_Homo sapiens_hsa041222.75001291
7Alcoholism_Homo sapiens_hsa050342.73275725
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.70808145
9Alzheimers disease_Homo sapiens_hsa050102.49095426
10Sulfur metabolism_Homo sapiens_hsa009202.39715819
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.32839665
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.25487485
13Huntingtons disease_Homo sapiens_hsa050162.18148624
14Caffeine metabolism_Homo sapiens_hsa002322.10957837
15Primary immunodeficiency_Homo sapiens_hsa053401.83781290
16Dorso-ventral axis formation_Homo sapiens_hsa043201.78798529
17Homologous recombination_Homo sapiens_hsa034401.74549689
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.62119146
19Proteasome_Homo sapiens_hsa030501.61831889
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54386293
21Folate biosynthesis_Homo sapiens_hsa007901.39504906
22Butanoate metabolism_Homo sapiens_hsa006501.26138842
23Carbohydrate digestion and absorption_Homo sapiens_hsa049731.17502722
24Fanconi anemia pathway_Homo sapiens_hsa034601.17169627
25Asthma_Homo sapiens_hsa053101.14661343
26Allograft rejection_Homo sapiens_hsa053301.11920939
27Autoimmune thyroid disease_Homo sapiens_hsa053201.10554466
28Graft-versus-host disease_Homo sapiens_hsa053321.05395441
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.02175155
30Mismatch repair_Homo sapiens_hsa034300.95391800
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94932611
32Type I diabetes mellitus_Homo sapiens_hsa049400.93168878
33One carbon pool by folate_Homo sapiens_hsa006700.92588964
34Phototransduction_Homo sapiens_hsa047440.92552544
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91494201
36Rheumatoid arthritis_Homo sapiens_hsa053230.86882892
37Primary bile acid biosynthesis_Homo sapiens_hsa001200.86126072
38Collecting duct acid secretion_Homo sapiens_hsa049660.84834115
39Cocaine addiction_Homo sapiens_hsa050300.83618620
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83515412
41Steroid hormone biosynthesis_Homo sapiens_hsa001400.82869940
42Basal cell carcinoma_Homo sapiens_hsa052170.80319223
43Selenocompound metabolism_Homo sapiens_hsa004500.77360794
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76439626
45Antigen processing and presentation_Homo sapiens_hsa046120.75838401
46Salivary secretion_Homo sapiens_hsa049700.75137171
47Phagosome_Homo sapiens_hsa041450.73166075
48Retinol metabolism_Homo sapiens_hsa008300.70357165
49p53 signaling pathway_Homo sapiens_hsa041150.66897337
50Insulin secretion_Homo sapiens_hsa049110.65502137
51Linoleic acid metabolism_Homo sapiens_hsa005910.61869050
52Nitrogen metabolism_Homo sapiens_hsa009100.61392588
53Gastric acid secretion_Homo sapiens_hsa049710.61127173
54Hematopoietic cell lineage_Homo sapiens_hsa046400.60039630
55Axon guidance_Homo sapiens_hsa043600.56262394
56Protein export_Homo sapiens_hsa030600.53770058
57Morphine addiction_Homo sapiens_hsa050320.53522358
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50665005
59Staphylococcus aureus infection_Homo sapiens_hsa051500.50066018
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49129960
61Chemical carcinogenesis_Homo sapiens_hsa052040.45806798
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45721711
63Purine metabolism_Homo sapiens_hsa002300.45484879
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44217250
65Basal transcription factors_Homo sapiens_hsa030220.43246473
66Hedgehog signaling pathway_Homo sapiens_hsa043400.43002551
67Bile secretion_Homo sapiens_hsa049760.41802562
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40549804
69Peroxisome_Homo sapiens_hsa041460.38318136
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37965190
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37647287
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37544493
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.36588585
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36440332
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36135021
76Metabolic pathways_Homo sapiens_hsa011000.35561133
77Leishmaniasis_Homo sapiens_hsa051400.35298706
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35139318
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34885327
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34424689
81Tryptophan metabolism_Homo sapiens_hsa003800.33939455
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33621041
83Olfactory transduction_Homo sapiens_hsa047400.32371504
84Oxytocin signaling pathway_Homo sapiens_hsa049210.31723375
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31642481
86cAMP signaling pathway_Homo sapiens_hsa040240.31599261
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.31128251
88Melanoma_Homo sapiens_hsa052180.30592817
89Pyrimidine metabolism_Homo sapiens_hsa002400.29837316
90Starch and sucrose metabolism_Homo sapiens_hsa005000.29293766
91Circadian entrainment_Homo sapiens_hsa047130.29152358
92Melanogenesis_Homo sapiens_hsa049160.28257996
93Spliceosome_Homo sapiens_hsa030400.27008091
94Notch signaling pathway_Homo sapiens_hsa043300.25552226
95Epstein-Barr virus infection_Homo sapiens_hsa051690.24755844
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24517331
97Gap junction_Homo sapiens_hsa045400.24477864
98Regulation of autophagy_Homo sapiens_hsa041400.22683584
99Viral carcinogenesis_Homo sapiens_hsa052030.21798572
100Cholinergic synapse_Homo sapiens_hsa047250.21593624

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