ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mast cell activation (GO:0045576)	4.83702506
2	sequestering of actin monomers (GO:0042989)	4.61260827
3	ribosomal small subunit assembly (GO:0000028)	4.59814814
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.33274356
5	ATP synthesis coupled proton transport (GO:0015986)	4.33274356
6	respiratory chain complex IV assembly (GO:0008535)	4.33242312
7	DNA deamination (GO:0045006)	4.25011537
8	NIK/NF-kappaB signaling (GO:0038061)	4.21900966
9	regulation of female receptivity (GO:0045924)	4.21235315
10	mast cell degranulation (GO:0043303)	4.19984691
11	mast cell activation involved in immune response (GO:0002279)	4.19984691
12	protein neddylation (GO:0045116)	4.01004963
13	cullin deneddylation (GO:0010388)	3.96654447
14	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.93220478
15	axoneme assembly (GO:0035082)	3.82435241
16	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.73035752
17	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.65141708
18	platelet dense granule organization (GO:0060155)	3.63194562
19	sleep (GO:0030431)	3.60316680
20	dopamine transport (GO:0015872)	3.54837119
21	GPI anchor metabolic process (GO:0006505)	3.52975536
22	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	3.40943264
23	female mating behavior (GO:0060180)	3.40809009
24	regulation of hypersensitivity (GO:0002883)	3.39237054
25	organic cation transport (GO:0015695)	3.38699077
26	GPI anchor biosynthetic process (GO:0006506)	3.36777351
27	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.32261865
28	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.31111634
29	actin nucleation (GO:0045010)	3.28123309
30	synaptic transmission, dopaminergic (GO:0001963)	3.27629238
31	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	3.27544908
32	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.25497056
33	T-helper cell differentiation (GO:0042093)	3.19962407
34	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	3.19962407
35	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	3.19960766
36	cytochrome complex assembly (GO:0017004)	3.19292488
37	protein deneddylation (GO:0000338)	3.18201593
38	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	3.12070458
39	regulation of memory T cell differentiation (GO:0043380)	3.07103691
40	regulation of activation of Janus kinase activity (GO:0010533)	3.06875008
41	positive regulation of interleukin-17 production (GO:0032740)	3.05578451
42	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.04847651
43	cytidine catabolic process (GO:0006216)	3.04378596
44	cytidine deamination (GO:0009972)	3.04378596
45	cytidine metabolic process (GO:0046087)	3.04378596
46	positive regulation of T-helper 1 type immune response (GO:0002827)	3.04152230
47	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.99515754
48	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.99515754
49	NADH dehydrogenase complex assembly (GO:0010257)	2.99515754
50	regulation of triglyceride catabolic process (GO:0010896)	2.99360402
51	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.98548190
52	protein complex biogenesis (GO:0070271)	2.97047393
53	positive regulation of protein homodimerization activity (GO:0090073)	2.96664530
54	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.96513704
55	termination of RNA polymerase III transcription (GO:0006386)	2.96513704
56	T cell receptor signaling pathway (GO:0050852)	2.92283432
57	respiratory electron transport chain (GO:0022904)	2.90770051
58	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.89223523
59	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.88239317
60	electron transport chain (GO:0022900)	2.87867926
61	alpha-beta T cell differentiation involved in immune response (GO:0002293)	2.86418564
62	alpha-beta T cell activation involved in immune response (GO:0002287)	2.86418564
63	T cell differentiation involved in immune response (GO:0002292)	2.86418564
64	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.85098561
65	neutrophil activation involved in immune response (GO:0002283)	2.83858954
66	negative regulation of mast cell activation (GO:0033004)	2.82621377
67	neutrophil activation (GO:0042119)	2.80081221
68	T cell costimulation (GO:0031295)	2.79615028
69	regulation of interleukin-8 secretion (GO:2000482)	2.77742012
70	regulation of T cell mediated cytotoxicity (GO:0001914)	2.77328775
71	response to gravity (GO:0009629)	2.76689634
72	positive regulation of interleukin-4 production (GO:0032753)	2.76374515
73	lymphocyte costimulation (GO:0031294)	2.76308139
74	regulation of protein glycosylation (GO:0060049)	2.71827153
75	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.71164731
76	I-kappaB phosphorylation (GO:0007252)	2.70511283
77	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.70307806
78	RNA destabilization (GO:0050779)	2.69830208
79	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	2.67598735
80	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	2.67598735
81	mitochondrial respiratory chain complex assembly (GO:0033108)	2.66264332
82	hydrogen ion transmembrane transport (GO:1902600)	2.62498865
83	negative regulation of nitric-oxide synthase activity (GO:0051001)	2.61102528
84	positive regulation of prostaglandin secretion (GO:0032308)	2.59629550
85	response to pheromone (GO:0019236)	2.58989924
86	glycolipid biosynthetic process (GO:0009247)	2.57525890
87	negative regulation of chemokine production (GO:0032682)	2.56670484
88	positive regulation of osteoclast differentiation (GO:0045672)	2.55150614
89	rhodopsin mediated signaling pathway (GO:0016056)	2.55041627
90	deoxyribonucleotide catabolic process (GO:0009264)	2.54400044
91	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	2.54293673
92	immunoglobulin mediated immune response (GO:0016064)	2.52411033
93	proton transport (GO:0015992)	2.52266737
94	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.49759514
95	regulation of isotype switching to IgG isotypes (GO:0048302)	2.49308246
96	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.48409237
97	deoxyribose phosphate catabolic process (GO:0046386)	2.45358530
98	regulation of cellular extravasation (GO:0002691)	2.45162627
99	negative regulation of T cell apoptotic process (GO:0070233)	2.45049964
100	hydrogen transport (GO:0006818)	2.44285839

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	6.84212389
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.06876054
3	VDR_22108803_ChIP-Seq_LS180_Human	4.02999024
4	EZH2_22144423_ChIP-Seq_EOC_Human	4.01235435
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.11900567
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.98518908
7	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.57686361
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.53223555
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.40136554
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.31013971
11	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.29219422
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.09823342
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.00904966
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.96627555
15	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.85109465
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.78179027
17	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.76567938
18	TP53_22573176_ChIP-Seq_HFKS_Human	1.66986880
19	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.63963530
20	GATA3_26560356_Chip-Seq_TH2_Human	1.59580750
21	SCL_19346495_ChIP-Seq_HPC-7_Human	1.58286867
22	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.56239678
23	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.55507658
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.55467513
25	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.52343787
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.50398370
27	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.47653436
28	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.47419260
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.45968089
30	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.44590912
31	AR_20517297_ChIP-Seq_VCAP_Human	1.39002520
32	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.38787752
33	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.36327143
34	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36216747
35	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36216747
36	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.36207427
37	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.35927841
38	MYC_18940864_ChIP-ChIP_HL60_Human	1.35239124
39	TAF2_19829295_ChIP-Seq_ESCs_Human	1.35080285
40	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.34812962
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.34137442
42	HTT_18923047_ChIP-ChIP_STHdh_Human	1.33083316
43	EGR1_19032775_ChIP-ChIP_M12_Human	1.32290395
44	ERG_20517297_ChIP-Seq_VCAP_Human	1.27311133
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.26880385
46	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26202044
47	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26202044
48	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.25918318
49	FOXP3_21729870_ChIP-Seq_TREG_Human	1.24201314
50	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.24088067
51	CIITA_25753668_ChIP-Seq_RAJI_Human	1.20590457
52	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.20400457
53	NANOG_20526341_ChIP-Seq_ESCs_Human	1.20353698
54	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.15962497
55	NCOR_22424771_ChIP-Seq_293T_Human	1.15658100
56	MYB_26560356_Chip-Seq_TH2_Human	1.15098639
57	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.14785286
58	FUS_26573619_Chip-Seq_HEK293_Human	1.14551963
59	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.14310514
60	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.12619182
61	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.09012130
62	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.08799315
63	EWS_26573619_Chip-Seq_HEK293_Human	1.08717080
64	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08643219
65	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.06860273
66	RNF2_27304074_Chip-Seq_NSC_Mouse	1.06580513
67	GATA3_27048872_Chip-Seq_THYMUS_Human	1.06426715
68	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.06017101
69	P300_19829295_ChIP-Seq_ESCs_Human	1.05969614
70	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.03721427
71	BCAT_22108803_ChIP-Seq_LS180_Human	1.02193157
72	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.01763195
73	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00662193
74	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00081481
75	RBPJ_21746931_ChIP-Seq_IB4_Human	0.99721106
76	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.98332001
77	GATA3_26560356_Chip-Seq_TH1_Human	0.98148784
78	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.98102201
79	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.95044829
80	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.94952391
81	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.94810549
82	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.94319257
83	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.93818704
84	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.93796717
85	ER_23166858_ChIP-Seq_MCF-7_Human	0.93194110
86	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.92540934
87	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.92269978
88	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.91917557
89	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.91917557
90	HOXB7_26014856_ChIP-Seq_BT474_Human	0.91462232
91	BCL6_27268052_Chip-Seq_Bcells_Human	0.90862148
92	RUNX_20019798_ChIP-Seq_JUKART_Human	0.90776848
93	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.89593613
94	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.87707200
95	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.87156263
96	ETV1_20927104_ChIP-Seq_GIST48_Human	0.87113158
97	ERA_21632823_ChIP-Seq_H3396_Human	0.86895408
98	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.86380592
99	P300_27268052_Chip-Seq_Bcells_Human	0.85188999
100	RXR_22108803_ChIP-Seq_LS180_Human	0.83949512

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002009_preneoplasia	4.77289474
2	MP0005671_abnormal_response_to	3.08425643
3	MP0002166_altered_tumor_susceptibility	2.97467578
4	MP0003724_increased_susceptibility_to	2.78499853
5	MP0002006_tumorigenesis	2.43536458
6	MP0004147_increased_porphyrin_level	2.38739156
7	MP0006072_abnormal_retinal_apoptosis	2.28428154
8	MP0009333_abnormal_splenocyte_physiolog	2.20173385
9	MP0001968_abnormal_touch/_nociception	2.11207031
10	MP0002736_abnormal_nociception_after	2.06968555
11	MP0003638_abnormal_response/metabolism_	2.05568634
12	MP0001835_abnormal_antigen_presentation	1.99495575
13	MP0002933_joint_inflammation	1.83892596
14	MP0005000_abnormal_immune_tolerance	1.78497974
15	MP0009785_altered_susceptibility_to	1.77549282
16	MP0001919_abnormal_reproductive_system	1.74040872
17	MP0008875_abnormal_xenobiotic_pharmacok	1.70613785
18	MP0002163_abnormal_gland_morphology	1.63286097
19	MP0002837_dystrophic_cardiac_calcinosis	1.63128798
20	MP0001986_abnormal_taste_sensitivity	1.62810756
21	MP0001879_abnormal_lymphatic_vessel	1.61486724
22	MP0009379_abnormal_foot_pigmentation	1.59357125
23	MP0006036_abnormal_mitochondrial_physio	1.54965885
24	MP0003436_decreased_susceptibility_to	1.52449719
25	MP0003787_abnormal_imprinting	1.52012909
26	MP0002102_abnormal_ear_morphology	1.50934995
27	MP0005551_abnormal_eye_electrophysiolog	1.50872755
28	MP0008872_abnormal_physiological_respon	1.48872768
29	MP0005253_abnormal_eye_physiology	1.47837472
30	MP0001661_extended_life_span	1.43433832
31	MP0009764_decreased_sensitivity_to	1.41163832
32	MP0001905_abnormal_dopamine_level	1.40537638
33	MP0002148_abnormal_hypersensitivity_rea	1.40363170
34	MP0002723_abnormal_immune_serum	1.39037572
35	MP0008995_early_reproductive_senescence	1.36110526
36	MP0003718_maternal_effect	1.35605009
37	MP0001800_abnormal_humoral_immune	1.33432132
38	MP0005389_reproductive_system_phenotype	1.33412019
39	MP0006276_abnormal_autonomic_nervous	1.33000424
40	MP0000647_abnormal_sebaceous_gland	1.31939556
41	MP0002822_catalepsy	1.29616109
42	MP0000427_abnormal_hair_cycle	1.26148523
43	MP0008877_abnormal_DNA_methylation	1.25800814
44	MP0003950_abnormal_plasma_membrane	1.22965237
45	MP0001819_abnormal_immune_cell	1.21853955
46	MP0005365_abnormal_bile_salt	1.20461916
47	MP0002557_abnormal_social/conspecific_i	1.20325150
48	MP0002420_abnormal_adaptive_immunity	1.19365407
49	MP0004019_abnormal_vitamin_homeostasis	1.18555942
50	MP0004885_abnormal_endolymph	1.13180721
51	MP0005084_abnormal_gallbladder_morpholo	1.10890260
52	MP0004142_abnormal_muscle_tone	1.10710889
53	MP0002452_abnormal_antigen_presenting	1.10008311
54	MP0002095_abnormal_skin_pigmentation	1.06992909
55	MP0003656_abnormal_erythrocyte_physiolo	1.06967507
56	MP0001542_abnormal_bone_strength	1.06470549
57	MP0001765_abnormal_ion_homeostasis	1.02916642
58	MP0005025_abnormal_response_to	1.02486961
59	MP0002876_abnormal_thyroid_physiology	1.01998746
60	MP0002272_abnormal_nervous_system	1.00861405
61	MP0005646_abnormal_pituitary_gland	1.00557294
62	MP0000230_abnormal_systemic_arterial	0.99887316
63	MP0002638_abnormal_pupillary_reflex	0.98400295
64	MP0009745_abnormal_behavioral_response	0.97107540
65	MP0004484_altered_response_of	0.96809612
66	MP0005645_abnormal_hypothalamus_physiol	0.96237084
67	MP0001845_abnormal_inflammatory_respons	0.95944931
68	MP0001502_abnormal_circadian_rhythm	0.95921562
69	MP0001501_abnormal_sleep_pattern	0.91121347
70	MP0002572_abnormal_emotion/affect_behav	0.90959558
71	MP0009643_abnormal_urine_homeostasis	0.89845022
72	MP0010155_abnormal_intestine_physiology	0.86938430
73	MP0009046_muscle_twitch	0.86718609
74	MP0001970_abnormal_pain_threshold	0.86567972
75	MP0008775_abnormal_heart_ventricle	0.85965602
76	MP0004145_abnormal_muscle_electrophysio	0.85607020
77	MP0001756_abnormal_urination	0.84189043
78	MP0006292_abnormal_olfactory_placode	0.84003941
79	MP0001119_abnormal_female_reproductive	0.83762942
80	MP0003763_abnormal_thymus_physiology	0.82116849
81	MP0009765_abnormal_xenobiotic_induced	0.82046383
82	MP0003866_abnormal_defecation	0.81750014
83	MP0000465_gastrointestinal_hemorrhage	0.81689189
84	MP0000716_abnormal_immune_system	0.81215410
85	MP0008770_decreased_survivor_rate	0.80207276
86	MP0001984_abnormal_olfaction	0.79220750
87	MP0000689_abnormal_spleen_morphology	0.77854774
88	MP0002398_abnormal_bone_marrow	0.76432783
89	MP0005367_renal/urinary_system_phenotyp	0.75990416
90	MP0000516_abnormal_urinary_system	0.75990416
91	MP0000538_abnormal_urinary_bladder	0.75942128
92	MP0008789_abnormal_olfactory_epithelium	0.75333681
93	MP0002160_abnormal_reproductive_system	0.74921146
94	MP0000383_abnormal_hair_follicle	0.73922315
95	MP0001533_abnormal_skeleton_physiology	0.72987657
96	MP0008469_abnormal_protein_level	0.72693934
97	MP0002419_abnormal_innate_immunity	0.71719768
98	MP0009763_increased_sensitivity_to	0.68345863
99	MP0008004_abnormal_stomach_pH	0.68157148
100	MP0004924_abnormal_behavior	0.66353559

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hepatocellular necrosis (HP:0001404)	4.16349823
2	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.95111131
3	Stomach cancer (HP:0012126)	3.59790056
4	Mitochondrial inheritance (HP:0001427)	3.51130118
5	True hermaphroditism (HP:0010459)	3.47843125
6	Pancreatic cysts (HP:0001737)	3.44107858
7	Amyotrophic lateral sclerosis (HP:0007354)	3.42315954
8	Hepatic necrosis (HP:0002605)	3.40738884
9	Acute necrotizing encephalopathy (HP:0006965)	3.38595430
10	Aplastic anemia (HP:0001915)	3.21832368
11	Hypoproteinemia (HP:0003075)	3.21201835
12	Type 2 muscle fiber atrophy (HP:0003554)	3.15615288
13	Abnormality of the prostate (HP:0008775)	3.11590165
14	Progressive macrocephaly (HP:0004481)	2.98530262
15	Constricted visual fields (HP:0001133)	2.95778335
16	Attenuation of retinal blood vessels (HP:0007843)	2.93397015
17	Abnormal mitochondria in muscle tissue (HP:0008316)	2.89803750
18	Abolished electroretinogram (ERG) (HP:0000550)	2.84908149
19	Acute encephalopathy (HP:0006846)	2.84149515
20	Pancreatic fibrosis (HP:0100732)	2.83167306
21	Abnormal biliary tract physiology (HP:0012439)	2.80728831
22	Bile duct proliferation (HP:0001408)	2.80728831
23	Hypoplasia of the uterus (HP:0000013)	2.79758663
24	Increased CSF lactate (HP:0002490)	2.79212214
25	3-Methylglutaconic aciduria (HP:0003535)	2.76759750
26	Clubbing of toes (HP:0100760)	2.72366763
27	Muscle fiber atrophy (HP:0100295)	2.70397408
28	Optic disc pallor (HP:0000543)	2.56792961
29	Hypothermia (HP:0002045)	2.50855183
30	Aplasia/hypoplasia of the uterus (HP:0008684)	2.47858176
31	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.42731426
32	Abnormality of eosinophils (HP:0001879)	2.35456893
33	Congenital stationary night blindness (HP:0007642)	2.34898790
34	Eosinophilia (HP:0001880)	2.33992557
35	Hypokalemic alkalosis (HP:0001949)	2.33063990
36	Chromsome breakage (HP:0040012)	2.31283771
37	Polyphagia (HP:0002591)	2.29576521
38	Metabolic alkalosis (HP:0200114)	2.29426231
39	Alveolar cell carcinoma (HP:0006519)	2.22341351
40	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.22305637
41	Polyuria (HP:0000103)	2.21446992
42	Male pseudohermaphroditism (HP:0000037)	2.15364688
43	Abnormality of the corticospinal tract (HP:0002492)	2.15216231
44	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.14915023
45	Dyschromatopsia (HP:0007641)	2.14377802
46	Abnormality of male internal genitalia (HP:0000022)	2.14223605
47	Ulnar deviation of the wrist (HP:0003049)	2.07813445
48	Abnormality of B cell number (HP:0010975)	2.06805109
49	Increased serum lactate (HP:0002151)	2.06744533
50	Meckel diverticulum (HP:0002245)	2.06497546
51	IgG deficiency (HP:0004315)	2.06454035
52	Thyroid-stimulating hormone excess (HP:0002925)	2.01964420
53	Abnormality of the ileum (HP:0001549)	2.00668514
54	Progressive microcephaly (HP:0000253)	1.99047184
55	Severe combined immunodeficiency (HP:0004430)	1.98832522
56	Widely patent fontanelles and sutures (HP:0004492)	1.97723301
57	Thyroiditis (HP:0100646)	1.96011264
58	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	1.94830456
59	Generalized aminoaciduria (HP:0002909)	1.94079560
60	Abnormality of T cell number (HP:0011839)	1.92971867
61	Panhypogammaglobulinemia (HP:0003139)	1.92642880
62	Agitation (HP:0000713)	1.91344800
63	Nemaline bodies (HP:0003798)	1.89857539
64	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.89778532
65	Prostate neoplasm (HP:0100787)	1.89719668
66	Abnormality of the lower motor neuron (HP:0002366)	1.89605551
67	Weak cry (HP:0001612)	1.89481006
68	Cystic liver disease (HP:0006706)	1.89082761
69	Broad-based gait (HP:0002136)	1.88946618
70	Congenital, generalized hypertrichosis (HP:0004540)	1.88677555
71	Pendular nystagmus (HP:0012043)	1.87489008
72	Hyperlipoproteinemia (HP:0010980)	1.86788252
73	Lactic acidosis (HP:0003128)	1.84516131
74	Abnormality of the labia minora (HP:0012880)	1.82827438
75	Cerebral edema (HP:0002181)	1.81613120
76	Lissencephaly (HP:0001339)	1.81339802
77	Abnormality of the renal cortex (HP:0011035)	1.80869125
78	Abnormal urine output (HP:0012590)	1.78356073
79	Calf muscle hypertrophy (HP:0008981)	1.78297944
80	Neoplasm of the tracheobronchial system (HP:0100552)	1.78033869
81	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.77465203
82	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.77465203
83	Abnormality of the preputium (HP:0100587)	1.77453810
84	Muscle fiber inclusion bodies (HP:0100299)	1.77135652
85	Oral leukoplakia (HP:0002745)	1.76654627
86	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.76209067
87	Bony spicule pigmentary retinopathy (HP:0007737)	1.76067714
88	Popliteal pterygium (HP:0009756)	1.75658575
89	Respiratory failure (HP:0002878)	1.74974101
90	Elevated erythrocyte sedimentation rate (HP:0003565)	1.74839124
91	Abnormal drinking behavior (HP:0030082)	1.74146449
92	Polydipsia (HP:0001959)	1.74146449
93	Myotonia (HP:0002486)	1.73246479
94	IgM deficiency (HP:0002850)	1.72235418
95	Pancytopenia (HP:0001876)	1.71462843
96	Poor head control (HP:0002421)	1.71214943
97	Leukodystrophy (HP:0002415)	1.70469617
98	Abnormality of chromosome stability (HP:0003220)	1.68751231
99	Keratoconjunctivitis sicca (HP:0001097)	1.68249458
100	Granulocytopenia (HP:0001913)	1.68200436

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	4.95427243
2	CDK19	4.58697619
3	MAP3K12	3.08334180
4	KDR	2.71103026
5	NUAK1	2.68691854
6	LIMK1	2.46729232
7	TESK2	2.34842770
8	SIK3	2.30347285
9	IKBKE	2.16901247
10	BMPR2	2.14296052
11	MYLK	2.06491697
12	CAMKK2	2.04821608
13	ZAK	2.04503273
14	MAP4K1	1.94873723
15	ERBB3	1.84885781
16	BMPR1B	1.73883447
17	TAOK3	1.68550968
18	OXSR1	1.66783602
19	STK39	1.64043603
20	MAPK13	1.61828580
21	FRK	1.49435586
22	MAP2K2	1.42171986
23	ADRBK2	1.39442301
24	PIK3CG	1.34551507
25	GRK6	1.28723808
26	NEK1	1.26265000
27	WNK4	1.25207096
28	MAP3K14	1.24344545
29	IKBKB	1.24006994
30	TRPM7	1.23781812
31	ILK	1.14933210
32	PRKCQ	1.02748772
33	TESK1	1.02396143
34	TIE1	1.00221749
35	SIK2	0.99630747
36	GRK1	0.92109473
37	RIPK4	0.91826183
38	TLK1	0.91169944
39	LCK	0.90832936
40	BRSK2	0.87504390
41	RPS6KA4	0.85720841
42	CCNB1	0.85359743
43	MAP3K13	0.81534322
44	WNK3	0.81459593
45	MARK1	0.80899170
46	MAP4K2	0.80855406
47	TXK	0.79400155
48	MARK3	0.79355473
49	DAPK3	0.79232958
50	SYK	0.78643581
51	TRIM28	0.77566085
52	CSF1R	0.75693567
53	MINK1	0.70579788
54	PHKG1	0.70414155
55	PHKG2	0.70414155
56	OBSCN	0.69519424
57	PRKG1	0.69299079
58	MKNK2	0.67954468
59	LYN	0.67622189
60	PRKD3	0.67347307
61	CSNK1G2	0.66316214
62	ROCK1	0.65041554
63	CSNK1G3	0.64950466
64	GRK7	0.62257361
65	CAMKK1	0.61545142
66	DYRK2	0.59083473
67	PRKCG	0.56449866
68	CSNK1A1L	0.56294912
69	CSNK1G1	0.56151743
70	PRKCE	0.55059101
71	DAPK1	0.54836829
72	BCR	0.53736433
73	CSNK1D	0.53541861
74	MAPK7	0.52539948
75	INSRR	0.51941035
76	ITK	0.49154133
77	BRSK1	0.48184116
78	CDK8	0.48136311
79	WNK1	0.47681280
80	BTK	0.46561477
81	STK11	0.45666986
82	PRKACA	0.44441994
83	PLK2	0.44363907
84	TEC	0.44210068
85	PRKCA	0.41670208
86	GRK5	0.41148088
87	DYRK1A	0.38611724
88	PASK	0.38231029
89	RPS6KA2	0.38004506
90	AURKB	0.36986002
91	IRAK1	0.36918210
92	KIT	0.36512099
93	EGFR	0.36362661
94	BCKDK	0.35628324
95	ZAP70	0.33246260
96	PRKAA2	0.32841756
97	CAMK2D	0.32661629
98	CDK4	0.31830239
99	CHUK	0.30667798
100	FES	0.30385021

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.03224214
2	Allograft rejection_Homo sapiens_hsa05330	3.48677720
3	Graft-versus-host disease_Homo sapiens_hsa05332	3.39755631
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.27249216
5	Oxidative phosphorylation_Homo sapiens_hsa00190	3.17417629
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.03624831
7	Type I diabetes mellitus_Homo sapiens_hsa04940	2.99948269
8	Parkinsons disease_Homo sapiens_hsa05012	2.88841513
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.81233353
10	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.40821607
11	Proteasome_Homo sapiens_hsa03050	2.23659990
12	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.15982833
13	Phototransduction_Homo sapiens_hsa04744	2.07266195
14	Rheumatoid arthritis_Homo sapiens_hsa05323	1.91542387
15	Viral myocarditis_Homo sapiens_hsa05416	1.87296950
16	Primary immunodeficiency_Homo sapiens_hsa05340	1.74346897
17	Ribosome_Homo sapiens_hsa03010	1.73565201
18	Antigen processing and presentation_Homo sapiens_hsa04612	1.67233214
19	Alzheimers disease_Homo sapiens_hsa05010	1.58668383
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.55199189
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.55086344
22	Collecting duct acid secretion_Homo sapiens_hsa04966	1.55008525
23	RNA polymerase_Homo sapiens_hsa03020	1.53614934
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.53249174
25	One carbon pool by folate_Homo sapiens_hsa00670	1.45912185
26	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.45300198
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.41831000
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.36249132
29	Leishmaniasis_Homo sapiens_hsa05140	1.29292488
30	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.28055361
31	Huntingtons disease_Homo sapiens_hsa05016	1.27056243
32	Olfactory transduction_Homo sapiens_hsa04740	1.17848829
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.16966436
34	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.15483141
35	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.14885517
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.11471000
37	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.10254427
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.02807745
39	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.02423393
40	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.01460209
41	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.99172056
42	Folate biosynthesis_Homo sapiens_hsa00790	0.98486095
43	Sulfur relay system_Homo sapiens_hsa04122	0.92122696
44	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.91379854
45	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.86465464
46	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.83718272
47	Ether lipid metabolism_Homo sapiens_hsa00565	0.83450494
48	Morphine addiction_Homo sapiens_hsa05032	0.83132133
49	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.80204031
50	Homologous recombination_Homo sapiens_hsa03440	0.74037944
51	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.72539006
52	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.70551512
53	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.67179185
54	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.62656806
55	Glutathione metabolism_Homo sapiens_hsa00480	0.59098826
56	Protein export_Homo sapiens_hsa03060	0.56642470
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55426941
58	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.55117525
59	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.53348935
60	Herpes simplex infection_Homo sapiens_hsa05168	0.52630561
61	Circadian entrainment_Homo sapiens_hsa04713	0.52524659
62	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.50913271
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50270555
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.49935231
65	Salivary secretion_Homo sapiens_hsa04970	0.46736281
66	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.46493964
67	Amphetamine addiction_Homo sapiens_hsa05031	0.46465798
68	Retinol metabolism_Homo sapiens_hsa00830	0.46023161
69	Non-homologous end-joining_Homo sapiens_hsa03450	0.45777280
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44765328
71	Mismatch repair_Homo sapiens_hsa03430	0.42666933
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.41936546
73	Basal transcription factors_Homo sapiens_hsa03022	0.40398878
74	Shigellosis_Homo sapiens_hsa05131	0.39373442
75	Legionellosis_Homo sapiens_hsa05134	0.39176781
76	Regulation of autophagy_Homo sapiens_hsa04140	0.38285835
77	Propanoate metabolism_Homo sapiens_hsa00640	0.38232100
78	Nicotine addiction_Homo sapiens_hsa05033	0.35630153
79	Circadian rhythm_Homo sapiens_hsa04710	0.32666161
80	Tryptophan metabolism_Homo sapiens_hsa00380	0.31764494
81	Tuberculosis_Homo sapiens_hsa05152	0.30565542
82	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.29461815
83	Caffeine metabolism_Homo sapiens_hsa00232	0.29045253
84	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.28855466
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.28330765
86	Gastric acid secretion_Homo sapiens_hsa04971	0.28024011
87	Purine metabolism_Homo sapiens_hsa00230	0.27421805
88	Butanoate metabolism_Homo sapiens_hsa00650	0.27377273
89	Phagosome_Homo sapiens_hsa04145	0.26531177
90	RNA degradation_Homo sapiens_hsa03018	0.26518577
91	Fat digestion and absorption_Homo sapiens_hsa04975	0.26250925
92	Metabolic pathways_Homo sapiens_hsa01100	0.24865894
93	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.24769283
94	Vibrio cholerae infection_Homo sapiens_hsa05110	0.24216550
95	Renin secretion_Homo sapiens_hsa04924	0.23904767
96	Taste transduction_Homo sapiens_hsa04742	0.20639653
97	Influenza A_Homo sapiens_hsa05164	0.19703612
98	Malaria_Homo sapiens_hsa05144	0.19556255
99	GABAergic synapse_Homo sapiens_hsa04727	0.19294778
100	Salmonella infection_Homo sapiens_hsa05132	0.18864473

HIGD1AP14

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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