ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	5.64200671
2	negative regulation of translation, ncRNA-mediated (GO:0040033)	5.64200671
3	regulation of translation, ncRNA-mediated (GO:0045974)	5.64200671
4	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	5.20660797
5	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	5.20660797
6	pyrimidine nucleobase catabolic process (GO:0006208)	5.02001190
7	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	4.97199880
8	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	4.97199880
9	facial nerve structural organization (GO:0021612)	4.56730213
10	proline transport (GO:0015824)	4.42796924
11	positive regulation of mRNA catabolic process (GO:0061014)	4.39604753
12	DNA double-strand break processing (GO:0000729)	4.18703275
13	nucleobase catabolic process (GO:0046113)	3.91097483
14	positive regulation of mRNA 3-end processing (GO:0031442)	3.82339932
15	cranial nerve structural organization (GO:0021604)	3.77227733
16	cellular response to interleukin-15 (GO:0071350)	3.69260068
17	regulation of synapse structural plasticity (GO:0051823)	3.67410643
18	positive regulation of amino acid transport (GO:0051957)	3.65276595
19	regulation of mRNA catabolic process (GO:0061013)	3.61893932
20	protein targeting to Golgi (GO:0000042)	3.58229157
21	establishment of protein localization to Golgi (GO:0072600)	3.56123419
22	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.48461986
23	positive regulation of mRNA processing (GO:0050685)	3.45084049
24	neurotransmitter-gated ion channel clustering (GO:0072578)	3.44686146
25	fatty acid elongation (GO:0030497)	3.43716742
26	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.41102343
27	response to pheromone (GO:0019236)	3.40237875
28	regulation of mRNA 3-end processing (GO:0031440)	3.36368165
29	positive regulation of mRNA metabolic process (GO:1903313)	3.35258527
30	neuron fate determination (GO:0048664)	3.32603888
31	heparin biosynthetic process (GO:0030210)	3.30399804
32	heparin metabolic process (GO:0030202)	3.30399804
33	cullin deneddylation (GO:0010388)	3.25848053
34	RNA destabilization (GO:0050779)	3.21502261
35	anatomical structure arrangement (GO:0048532)	3.18006233
36	mismatch repair (GO:0006298)	3.17504955
37	mannosylation (GO:0097502)	3.17038276
38	male meiosis (GO:0007140)	3.15557489
39	synapsis (GO:0007129)	3.12950432
40	retinal cone cell development (GO:0046549)	3.11959364
41	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.09485094
42	piRNA metabolic process (GO:0034587)	3.06830992
43	vocalization behavior (GO:0071625)	3.03054536
44	regulation of telomere maintenance (GO:0032204)	3.02564388
45	histone H2A acetylation (GO:0043968)	3.01837732
46	striatum development (GO:0021756)	3.01252208
47	protein K11-linked deubiquitination (GO:0035871)	3.00089394
48	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.99720384
49	platelet dense granule organization (GO:0060155)	2.99174674
50	behavioral response to ethanol (GO:0048149)	2.97861670
51	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.94548037
52	regulation of mitotic spindle checkpoint (GO:1903504)	2.94548037
53	regulation of DNA endoreduplication (GO:0032875)	2.93148578
54	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.92992315
55	neural tube formation (GO:0001841)	2.91966036
56	regulation of telomere maintenance via telomerase (GO:0032210)	2.91313990
57	protein deneddylation (GO:0000338)	2.91308450
58	resolution of meiotic recombination intermediates (GO:0000712)	2.88883415
59	DNA catabolic process, exonucleolytic (GO:0000738)	2.86295073
60	photoreceptor cell maintenance (GO:0045494)	2.85343485
61	negative regulation of mast cell activation (GO:0033004)	2.84716803
62	cilium morphogenesis (GO:0060271)	2.83204040
63	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.82628855
64	male meiosis I (GO:0007141)	2.80336789
65	DNA methylation involved in gamete generation (GO:0043046)	2.79871796
66	nonribosomal peptide biosynthetic process (GO:0019184)	2.79176806
67	axoneme assembly (GO:0035082)	2.78688966
68	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.76980037
69	regulation of collateral sprouting (GO:0048670)	2.75153541
70	tachykinin receptor signaling pathway (GO:0007217)	2.74547956
71	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.71993736
72	glutathione biosynthetic process (GO:0006750)	2.69979348
73	presynaptic membrane assembly (GO:0097105)	2.69248978
74	protein polyglutamylation (GO:0018095)	2.68917137
75	regulation of cilium movement (GO:0003352)	2.65779301
76	intra-Golgi vesicle-mediated transport (GO:0006891)	2.64958832
77	protein K11-linked ubiquitination (GO:0070979)	2.63040642
78	central nervous system neuron axonogenesis (GO:0021955)	2.62380768
79	histone mRNA catabolic process (GO:0071044)	2.61127582
80	response to interleukin-15 (GO:0070672)	2.59596156
81	protein localization to Golgi apparatus (GO:0034067)	2.58932914
82	tolerance induction (GO:0002507)	2.58265459
83	postreplication repair (GO:0006301)	2.57900846
84	negative regulation of telomere maintenance (GO:0032205)	2.57403048
85	protein K6-linked ubiquitination (GO:0085020)	2.56613575
86	eye photoreceptor cell development (GO:0042462)	2.55608210
87	regulation of fibroblast apoptotic process (GO:2000269)	2.54819120
88	central nervous system projection neuron axonogenesis (GO:0021952)	2.52873954
89	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.50404000
90	neuronal action potential propagation (GO:0019227)	2.50077409
91	detection of light stimulus involved in sensory perception (GO:0050962)	2.50047888
92	detection of light stimulus involved in visual perception (GO:0050908)	2.50047888
93	gamma-aminobutyric acid transport (GO:0015812)	2.49137917
94	transmission of nerve impulse (GO:0019226)	2.49065292
95	one-carbon compound transport (GO:0019755)	2.47994694
96	peristalsis (GO:0030432)	2.47746096
97	DNA replication-dependent nucleosome organization (GO:0034723)	2.47679000
98	DNA replication-dependent nucleosome assembly (GO:0006335)	2.47679000
99	photoreceptor cell development (GO:0042461)	2.46095316
100	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.45451943

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	4.09617712
2	TAF15_26573619_Chip-Seq_HEK293_Human	3.35291703
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.27724787
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.19616816
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.18114256
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.97500236
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.88047887
8	VDR_22108803_ChIP-Seq_LS180_Human	2.86675970
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.84058843
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.62978918
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.48979660
12	FUS_26573619_Chip-Seq_HEK293_Human	2.35833862
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.27838984
14	EWS_26573619_Chip-Seq_HEK293_Human	2.26390166
15	P300_19829295_ChIP-Seq_ESCs_Human	2.24562614
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.21246134
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.19840150
18	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.10174259
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.06231587
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.05087092
21	SMAD4_21799915_ChIP-Seq_A2780_Human	1.84118071
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.81059584
23	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.77564988
24	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.75338134
25	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.74827197
26	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.69405761
27	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.69253705
28	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.68976639
29	BCAT_22108803_ChIP-Seq_LS180_Human	1.66102090
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.65827655
31	STAT3_23295773_ChIP-Seq_U87_Human	1.62631426
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.61666643
33	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.61131946
34	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.58485092
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.58424489
36	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.58334283
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.57476992
38	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.56425720
39	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.55952705
40	RNF2_27304074_Chip-Seq_NSC_Mouse	1.55452095
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.55312305
42	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.53276115
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.52674742
44	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.52082051
45	AR_25329375_ChIP-Seq_VCAP_Human	1.47585332
46	TCF4_22108803_ChIP-Seq_LS180_Human	1.47166751
47	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.46762200
48	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.44795494
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.43513160
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.43513160
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.42017770
52	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.41366177
53	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.41136820
54	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.40732508
55	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.39753558
56	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.39076543
57	TCF4_23295773_ChIP-Seq_U87_Human	1.38015033
58	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.37312505
59	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.36624679
60	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36624679
61	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.36437073
62	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.33095226
63	VDR_23849224_ChIP-Seq_CD4+_Human	1.28221529
64	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.27947149
65	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.27312366
66	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.26690622
67	RUNX2_22187159_ChIP-Seq_PCA_Human	1.25736350
68	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.25438062
69	P53_22387025_ChIP-Seq_ESCs_Mouse	1.24215049
70	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.23975554
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23218295
72	P300_18555785_Chip-Seq_ESCs_Mouse	1.22431623
73	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22332352
74	MYC_18940864_ChIP-ChIP_HL60_Human	1.22150254
75	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.20577365
76	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.18187964
77	TP53_22573176_ChIP-Seq_HFKS_Human	1.17006934
78	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.16365480
79	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.14146675
80	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.09434980
81	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.08694566
82	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.08300389
83	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08011747
84	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.07978903
85	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06876699
86	IRF1_19129219_ChIP-ChIP_H3396_Human	1.05679901
87	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.04390313
88	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.04319735
89	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.03990997
90	JUN_21703547_ChIP-Seq_K562_Human	1.03421222
91	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.02975535
92	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.02329498
93	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.02305465
94	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01741554
95	KDM2B_26808549_Chip-Seq_REH_Human	1.01639102
96	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01590291
97	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01590291
98	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.01243856
99	SOX9_26525672_Chip-Seq_HEART_Mouse	1.00833571
100	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.99150625

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.93442157
2	MP0002102_abnormal_ear_morphology	4.69588507
3	MP0003880_abnormal_central_pattern	3.19408076
4	MP0002822_catalepsy	3.07943687
5	MP0008057_abnormal_DNA_replication	2.89598528
6	MP0000427_abnormal_hair_cycle	2.74095435
7	MP0002009_preneoplasia	2.73341460
8	MP0003787_abnormal_imprinting	2.55561012
9	MP0001486_abnormal_startle_reflex	2.54369728
10	MP0002736_abnormal_nociception_after	2.26416568
11	MP0001984_abnormal_olfaction	2.18633108
12	MP0005167_abnormal_blood-brain_barrier	2.14702467
13	MP0008058_abnormal_DNA_repair	2.13590334
14	MP0000372_irregular_coat_pigmentation	2.02597191
15	MP0001968_abnormal_touch/_nociception	1.95948712
16	MP0004924_abnormal_behavior	1.89749857
17	MP0005386_behavior/neurological_phenoty	1.89749857
18	MP0000015_abnormal_ear_pigmentation	1.89213833
19	MP0005551_abnormal_eye_electrophysiolog	1.72525388
20	MP0009745_abnormal_behavioral_response	1.69557115
21	MP0003121_genomic_imprinting	1.62119879
22	MP0001501_abnormal_sleep_pattern	1.56369532
23	MP0005253_abnormal_eye_physiology	1.52326255
24	MP0000465_gastrointestinal_hemorrhage	1.52240955
25	MP0000647_abnormal_sebaceous_gland	1.49819201
26	MP0002734_abnormal_mechanical_nocicepti	1.38701752
27	MP0002272_abnormal_nervous_system	1.36720014
28	MP0008875_abnormal_xenobiotic_pharmacok	1.36436946
29	MP0004215_abnormal_myocardial_fiber	1.34124185
30	MP0005083_abnormal_biliary_tract	1.32154309
31	MP0003635_abnormal_synaptic_transmissio	1.32115550
32	MP0009046_muscle_twitch	1.30981844
33	MP0004133_heterotaxia	1.29114316
34	MP0002095_abnormal_skin_pigmentation	1.28058250
35	MP0002557_abnormal_social/conspecific_i	1.26596099
36	MP0002233_abnormal_nose_morphology	1.22454931
37	MP0001529_abnormal_vocalization	1.21480167
38	MP0001929_abnormal_gametogenesis	1.21353607
39	MP0010094_abnormal_chromosome_stability	1.19769052
40	MP0004043_abnormal_pH_regulation	1.19458318
41	MP0001243_abnormal_dermal_layer	1.17152611
42	MP0002572_abnormal_emotion/affect_behav	1.17140148
43	MP0004270_analgesia	1.17069664
44	MP0001919_abnormal_reproductive_system	1.16006106
45	MP0000778_abnormal_nervous_system	1.15438638
46	MP0002063_abnormal_learning/memory/cond	1.15380925
47	MP0002210_abnormal_sex_determination	1.10586589
48	MP0002160_abnormal_reproductive_system	1.10275083
49	MP0002938_white_spotting	1.09853679
50	MP0006072_abnormal_retinal_apoptosis	1.09813196
51	MP0000569_abnormal_digit_pigmentation	1.09282783
52	MP0001764_abnormal_homeostasis	1.08602266
53	MP0002067_abnormal_sensory_capabilities	1.05834696
54	MP0008995_early_reproductive_senescence	1.04973015
55	MP0005075_abnormal_melanosome_morpholog	1.02853673
56	MP0002752_abnormal_somatic_nervous	1.02429504
57	MP0005389_reproductive_system_phenotype	1.00940961
58	MP0003943_abnormal_hepatobiliary_system	1.00846878
59	MP0003718_maternal_effect	0.99068033
60	MP0005423_abnormal_somatic_nervous	0.97469029
61	MP0001905_abnormal_dopamine_level	0.97311718
62	MP0003937_abnormal_limbs/digits/tail_de	0.96596998
63	MP0003567_abnormal_fetal_cardiomyocyte	0.96029077
64	MP0003698_abnormal_male_reproductive	0.95514524
65	MP0000653_abnormal_sex_gland	0.94680221
66	MP0003111_abnormal_nucleus_morphology	0.93420643
67	MP0001188_hyperpigmentation	0.93211146
68	MP0001177_atelectasis	0.93148415
69	MP0002735_abnormal_chemical_nociception	0.91563364
70	MP0002837_dystrophic_cardiac_calcinosis	0.91028322
71	MP0005394_taste/olfaction_phenotype	0.91014975
72	MP0005499_abnormal_olfactory_system	0.91014975
73	MP0002876_abnormal_thyroid_physiology	0.90840659
74	MP0002184_abnormal_innervation	0.90752438
75	MP0002064_seizures	0.90393170
76	MP0002254_reproductive_system_inflammat	0.89253013
77	MP0005248_abnormal_Harderian_gland	0.89069694
78	MP0005310_abnormal_salivary_gland	0.87981445
79	MP0001324_abnormal_eye_pigmentation	0.87102857
80	MP0001145_abnormal_male_reproductive	0.87084017
81	MP0005645_abnormal_hypothalamus_physiol	0.86975939
82	MP0003011_delayed_dark_adaptation	0.86541647
83	MP0002733_abnormal_thermal_nociception	0.84516976
84	MP0004381_abnormal_hair_follicle	0.82600777
85	MP0008872_abnormal_physiological_respon	0.82235931
86	MP0002882_abnormal_neuron_morphology	0.82200140
87	MP0008932_abnormal_embryonic_tissue	0.79925981
88	MP0003786_premature_aging	0.77390481
89	MP0009703_decreased_birth_body	0.76983235
90	MP0003119_abnormal_digestive_system	0.76638481
91	MP0006276_abnormal_autonomic_nervous	0.76445920
92	MP0001970_abnormal_pain_threshold	0.75264302
93	MP0001986_abnormal_taste_sensitivity	0.73919845
94	MP0005171_absent_coat_pigmentation	0.73538123
95	MP0000955_abnormal_spinal_cord	0.71928319
96	MP0000749_muscle_degeneration	0.71321812
97	MP0002066_abnormal_motor_capabilities/c	0.69945555
98	MP0002751_abnormal_autonomic_nervous	0.69468980
99	MP0003890_abnormal_embryonic-extraembry	0.68843495
100	MP0003633_abnormal_nervous_system	0.68319689

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Febrile seizures (HP:0002373)	4.28739692
2	Progressive inability to walk (HP:0002505)	3.58713665
3	Pendular nystagmus (HP:0012043)	3.57232333
4	Medial flaring of the eyebrow (HP:0010747)	3.50806012
5	Gait imbalance (HP:0002141)	3.34209443
6	Congenital primary aphakia (HP:0007707)	3.28628886
7	Stomach cancer (HP:0012126)	3.24704941
8	Horizontal nystagmus (HP:0000666)	3.21793924
9	Cerebellar dysplasia (HP:0007033)	3.16869618
10	Molar tooth sign on MRI (HP:0002419)	3.16265390
11	Abnormality of midbrain morphology (HP:0002418)	3.16265390
12	Type II lissencephaly (HP:0007260)	3.12202856
13	Nephronophthisis (HP:0000090)	3.07272045
14	Nephrogenic diabetes insipidus (HP:0009806)	3.04084959
15	Inability to walk (HP:0002540)	3.00047943
16	Colon cancer (HP:0003003)	2.84938606
17	Lissencephaly (HP:0001339)	2.77545197
18	Vaginal atresia (HP:0000148)	2.71046096
19	Absent speech (HP:0001344)	2.69544461
20	Genital tract atresia (HP:0001827)	2.69366502
21	Abnormality of the renal medulla (HP:0100957)	2.63208823
22	Amyotrophic lateral sclerosis (HP:0007354)	2.58958945
23	Volvulus (HP:0002580)	2.57068322
24	Methylmalonic acidemia (HP:0002912)	2.50743172
25	Pancreatic cysts (HP:0001737)	2.41846027
26	Abnormality of the astrocytes (HP:0100707)	2.41549435
27	Astrocytoma (HP:0009592)	2.41549435
28	Hyperventilation (HP:0002883)	2.39745094
29	Abnormality of the labia minora (HP:0012880)	2.36499035
30	Broad-based gait (HP:0002136)	2.33347654
31	Glioma (HP:0009733)	2.32976699
32	Atonic seizures (HP:0010819)	2.31105725
33	Prominent metopic ridge (HP:0005487)	2.28776968
34	Hypoplastic iliac wings (HP:0002866)	2.26826632
35	Abnormal protein N-linked glycosylation (HP:0012347)	2.24888388
36	Abnormal protein glycosylation (HP:0012346)	2.24888388
37	Abnormal glycosylation (HP:0012345)	2.24888388
38	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.24888388
39	Hypothermia (HP:0002045)	2.24133274
40	Abnormality of the renal cortex (HP:0011035)	2.23252078
41	Birth length less than 3rd percentile (HP:0003561)	2.22037886
42	Short middle phalanx of the 5th finger (HP:0004220)	2.19979150
43	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.19429300
44	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.19429300
45	Poor coordination (HP:0002370)	2.15793834
46	Type I transferrin isoform profile (HP:0003642)	2.15216937
47	Protruding tongue (HP:0010808)	2.13049193
48	B lymphocytopenia (HP:0010976)	2.12126290
49	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.10179468
50	Small hand (HP:0200055)	2.09313279
51	Hypoplasia of the pons (HP:0012110)	2.09016729
52	Pancreatic fibrosis (HP:0100732)	2.07613020
53	Retinal dysplasia (HP:0007973)	2.05770823
54	Abnormality of the metopic suture (HP:0005556)	2.05462491
55	Hypoplastic labia majora (HP:0000059)	2.05180162
56	Thyroiditis (HP:0100646)	2.02834892
57	Epidermoid cyst (HP:0200040)	2.01549374
58	Pachygyria (HP:0001302)	2.00570726
59	Drooling (HP:0002307)	1.99936307
60	Abnormality of the corticospinal tract (HP:0002492)	1.99795509
61	Astigmatism (HP:0000483)	1.99007592
62	Focal seizures (HP:0007359)	1.98266441
63	Abnormality of B cell number (HP:0010975)	1.96500902
64	Renal cortical cysts (HP:0000803)	1.95916833
65	Broad foot (HP:0001769)	1.95191764
66	Severe muscular hypotonia (HP:0006829)	1.95171764
67	Stomatitis (HP:0010280)	1.94038852
68	Polymicrogyria (HP:0002126)	1.93608092
69	Widely spaced teeth (HP:0000687)	1.91150578
70	Optic nerve hypoplasia (HP:0000609)	1.90805626
71	Abnormality of the lower motor neuron (HP:0002366)	1.89787276
72	Muscular hypotonia of the trunk (HP:0008936)	1.89446406
73	Shoulder girdle muscle weakness (HP:0003547)	1.88574280
74	Prominent nasal bridge (HP:0000426)	1.88420438
75	Hypoplastic female external genitalia (HP:0012815)	1.88307669
76	True hermaphroditism (HP:0010459)	1.87890754
77	Metaphyseal dysplasia (HP:0100255)	1.87625433
78	Impaired vibration sensation in the lower limbs (HP:0002166)	1.87094880
79	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.86917097
80	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.86502144
81	Bifid tongue (HP:0010297)	1.86149426
82	Neonatal respiratory distress (HP:0002643)	1.85217660
83	Abnormality of the pons (HP:0007361)	1.84735957
84	Gaze-evoked nystagmus (HP:0000640)	1.82574019
85	Labial hypoplasia (HP:0000066)	1.81706146
86	Abnormality of the labia majora (HP:0012881)	1.81053422
87	Hyperglycinemia (HP:0002154)	1.79984590
88	Rimmed vacuoles (HP:0003805)	1.79507873
89	Abolished electroretinogram (ERG) (HP:0000550)	1.79043744
90	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.78990465
91	Methylmalonic aciduria (HP:0012120)	1.78739614
92	Increased number of teeth (HP:0011069)	1.77517712
93	Excessive salivation (HP:0003781)	1.77240584
94	Tubulointerstitial nephritis (HP:0001970)	1.76820858
95	Severe combined immunodeficiency (HP:0004430)	1.75160839
96	IgG deficiency (HP:0004315)	1.74931157
97	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.72941034
98	Impaired social interactions (HP:0000735)	1.72782784
99	Abnormal social behavior (HP:0012433)	1.72782784
100	Hypsarrhythmia (HP:0002521)	1.72567376

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	3.72012777
2	FRK	3.55551227
3	MAP3K4	3.36555528
4	BCR	3.13007499
5	MAP4K2	3.04835631
6	TRIM28	2.99919612
7	MARK1	2.87211685
8	MAP2K7	2.33345886
9	ERBB3	2.28970221
10	NTRK3	2.26633712
11	GRK1	2.23473253
12	PNCK	2.19940826
13	TAOK3	2.16917472
14	WNK3	2.10048029
15	ADRBK2	2.07971405
16	MAPK13	2.07588868
17	TNIK	1.82618703
18	SIK3	1.77094684
19	MST4	1.69664695
20	MAP3K12	1.61111202
21	EPHA4	1.55737377
22	ACVR1B	1.54855393
23	PLK2	1.50774135
24	CSNK1G2	1.42594799
25	YES1	1.40065016
26	CSNK1A1L	1.38906888
27	CSNK1G3	1.36370336
28	BMPR1B	1.35504382
29	NUAK1	1.34450115
30	CSNK1G1	1.33149332
31	AKT3	1.32226767
32	DYRK2	1.28474229
33	PTK2B	1.26603736
34	FGR	1.22645699
35	MARK3	1.16772161
36	OXSR1	1.11872320
37	TSSK6	1.07550300
38	SRPK1	1.06757546
39	CLK1	1.06481144
40	ERBB4	1.05912174
41	SIK2	1.05838285
42	CAMKK2	1.00742473
43	EIF2AK3	0.96402079
44	ATR	0.87272011
45	PAK3	0.85774868
46	PLK4	0.83452803
47	MINK1	0.81969752
48	MAP2K4	0.79563877
49	PLK3	0.78125737
50	IRAK1	0.74016077
51	KSR1	0.72664107
52	DYRK3	0.71776183
53	BRAF	0.69751879
54	PDK2	0.67207646
55	MET	0.65708101
56	CDK5	0.64820279
57	MAP3K5	0.62899413
58	ATM	0.62507184
59	WEE1	0.59272036
60	MKNK2	0.59243970
61	CSF1R	0.57135633
62	CDC7	0.56535482
63	PRKCE	0.54420387
64	ZAK	0.53554793
65	TTK	0.51993097
66	EGFR	0.51933415
67	CAMK2A	0.51796219
68	BRSK2	0.47595519
69	CDK3	0.47196797
70	JAK1	0.46009180
71	INSRR	0.44371454
72	ROCK1	0.41922108
73	PLK1	0.41808390
74	CSNK1E	0.41530305
75	SGK2	0.39578727
76	STK39	0.37485673
77	IGF1R	0.37381897
78	CSNK1D	0.36559329
79	STK16	0.35818870
80	WNK4	0.35011834
81	PRKG1	0.34930555
82	RPS6KA4	0.34732662
83	PINK1	0.33166690
84	GRK5	0.32430382
85	PRKCG	0.32298949
86	BUB1	0.32157150
87	PIK3CA	0.31954266
88	CAMK2D	0.31615097
89	TNK2	0.31243173
90	NTRK2	0.27766462
91	TLK1	0.26701822
92	TEC	0.26645254
93	PRKACA	0.25012557
94	VRK1	0.24581634
95	GRK6	0.24397737
96	GSK3A	0.24019544
97	PRKCZ	0.23691407
98	FER	0.23671043
99	STK10	0.23096627
100	CHEK1	0.22772281

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.58690075
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.18500311
3	Nicotine addiction_Homo sapiens_hsa05033	3.13781567
4	RNA degradation_Homo sapiens_hsa03018	2.76188369
5	Taste transduction_Homo sapiens_hsa04742	2.71204807
6	Non-homologous end-joining_Homo sapiens_hsa03450	2.50226060
7	Steroid biosynthesis_Homo sapiens_hsa00100	2.44674804
8	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.18823299
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.17272803
10	Phototransduction_Homo sapiens_hsa04744	2.13397673
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.08158401
12	Fatty acid elongation_Homo sapiens_hsa00062	2.06829335
13	Homologous recombination_Homo sapiens_hsa03440	2.01918388
14	Butanoate metabolism_Homo sapiens_hsa00650	1.99605746
15	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.93135990
16	Proteasome_Homo sapiens_hsa03050	1.81356131
17	Propanoate metabolism_Homo sapiens_hsa00640	1.80296690
18	Basal transcription factors_Homo sapiens_hsa03022	1.78425313
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.63636464
20	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.56274470
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.55129333
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.54479138
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.51025173
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.38690494
25	RNA polymerase_Homo sapiens_hsa03020	1.37245078
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.34414338
27	Nucleotide excision repair_Homo sapiens_hsa03420	1.29098899
28	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.28044545
29	Fatty acid metabolism_Homo sapiens_hsa01212	1.26266223
30	Protein export_Homo sapiens_hsa03060	1.25931974
31	RNA transport_Homo sapiens_hsa03013	1.24634028
32	Morphine addiction_Homo sapiens_hsa05032	1.24563276
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.23918428
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.22224774
35	Dopaminergic synapse_Homo sapiens_hsa04728	1.21742102
36	GABAergic synapse_Homo sapiens_hsa04727	1.20736238
37	Selenocompound metabolism_Homo sapiens_hsa00450	1.17417780
38	Regulation of autophagy_Homo sapiens_hsa04140	1.10154030
39	Mismatch repair_Homo sapiens_hsa03430	1.08737235
40	Glutamatergic synapse_Homo sapiens_hsa04724	1.08702759
41	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.07675250
42	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.05805905
43	Circadian entrainment_Homo sapiens_hsa04713	1.05696739
44	Primary immunodeficiency_Homo sapiens_hsa05340	1.04285688
45	Olfactory transduction_Homo sapiens_hsa04740	1.02951302
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.02896151
47	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.93959384
48	Salivary secretion_Homo sapiens_hsa04970	0.93778908
49	mRNA surveillance pathway_Homo sapiens_hsa03015	0.93334304
50	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.91916010
51	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.91912251
52	Nitrogen metabolism_Homo sapiens_hsa00910	0.87695725
53	Oocyte meiosis_Homo sapiens_hsa04114	0.86370870
54	Glutathione metabolism_Homo sapiens_hsa00480	0.84320218
55	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.83080489
56	Cocaine addiction_Homo sapiens_hsa05030	0.82060545
57	DNA replication_Homo sapiens_hsa03030	0.78643226
58	Serotonergic synapse_Homo sapiens_hsa04726	0.77776831
59	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.75906506
60	Axon guidance_Homo sapiens_hsa04360	0.74488981
61	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.69218011
62	Pyruvate metabolism_Homo sapiens_hsa00620	0.68509097
63	Cell cycle_Homo sapiens_hsa04110	0.67875328
64	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.66481748
65	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.65790359
66	Collecting duct acid secretion_Homo sapiens_hsa04966	0.65069650
67	Amphetamine addiction_Homo sapiens_hsa05031	0.64577594
68	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.64394538
69	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.59272489
70	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.59137789
71	One carbon pool by folate_Homo sapiens_hsa00670	0.58875651
72	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.54949247
73	Base excision repair_Homo sapiens_hsa03410	0.54666410
74	Peroxisome_Homo sapiens_hsa04146	0.51749695
75	Lysine degradation_Homo sapiens_hsa00310	0.51273400
76	Purine metabolism_Homo sapiens_hsa00230	0.50014057
77	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.49444311
78	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.46792535
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.43115347
80	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.42320367
81	Caffeine metabolism_Homo sapiens_hsa00232	0.40098099
82	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.39290579
83	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.38900616
84	Gastric acid secretion_Homo sapiens_hsa04971	0.38642547
85	Fatty acid degradation_Homo sapiens_hsa00071	0.38424989
86	Pyrimidine metabolism_Homo sapiens_hsa00240	0.38274906
87	ABC transporters_Homo sapiens_hsa02010	0.38218510
88	Metabolic pathways_Homo sapiens_hsa01100	0.38120323
89	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.37805021
90	Chemical carcinogenesis_Homo sapiens_hsa05204	0.37716644
91	Long-term depression_Homo sapiens_hsa04730	0.37304806
92	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.36217574
93	Retinol metabolism_Homo sapiens_hsa00830	0.35671895
94	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.33087506
95	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.30857267
96	Legionellosis_Homo sapiens_hsa05134	0.29156162
97	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.28025244
98	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.27747158
99	p53 signaling pathway_Homo sapiens_hsa04115	0.27623494
100	cAMP signaling pathway_Homo sapiens_hsa04024	0.27171258

HIGD1AP16

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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