HIGD1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the hypoxia inducible gene 1 (HIG1) domain family. The encoded protein is localized to the cell membrane and has been linked to tumorigenesis and the progression of pituitary adenomas. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endocardial cushion morphogenesis (GO:0003203)7.78918401
2lymph vessel development (GO:0001945)7.43993890
3epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)7.42104639
4positive regulation of endothelial cell apoptotic process (GO:2000353)7.27637173
5coronary vasculature morphogenesis (GO:0060977)7.19599647
6positive regulation of inositol phosphate biosynthetic process (GO:0060732)7.03358195
7positive regulation of uterine smooth muscle contraction (GO:0070474)6.89854604
8gamma-aminobutyric acid transport (GO:0015812)6.84315066
9ventricular trabecula myocardium morphogenesis (GO:0003222)6.73791625
10negative regulation of cardiac muscle cell apoptotic process (GO:0010667)6.70562716
11relaxation of smooth muscle (GO:0044557)6.62350800
12Notch signaling involved in heart development (GO:0061314)6.59124040
13endothelium development (GO:0003158)6.13207091
14cardiac right ventricle morphogenesis (GO:0003215)6.12070407
15negative regulation of homotypic cell-cell adhesion (GO:0034111)6.08857077
16mesenchyme morphogenesis (GO:0072132)5.85368559
17positive regulation of neurotransmitter secretion (GO:0001956)5.83664721
18heart valve formation (GO:0003188)5.71594625
19regulation of inositol phosphate biosynthetic process (GO:0010919)5.65071485
20heart trabecula morphogenesis (GO:0061384)5.64977690
21negative regulation of cytosolic calcium ion concentration (GO:0051481)5.58659155
22cell migration involved in heart development (GO:0060973)5.50053837
23regulation of uterine smooth muscle contraction (GO:0070472)5.46457843
24cardiac left ventricle morphogenesis (GO:0003214)5.44630267
25regulation of vasculogenesis (GO:2001212)5.39069100
26negative regulation of smooth muscle cell differentiation (GO:0051151)5.30548343
27mesenchymal cell development (GO:0014031)5.30448364
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.27609769
29positive regulation of catenin import into nucleus (GO:0035413)5.23478972
30kidney mesenchyme development (GO:0072074)5.03887762
31glomerular filtration (GO:0003094)4.98104087
32trabecula morphogenesis (GO:0061383)4.78035891
33positive regulation of heart rate (GO:0010460)4.76805481
34glomerulus development (GO:0032835)4.73559033
35cochlea development (GO:0090102)4.72695076
36histamine secretion (GO:0001821)4.63975952
37cGMP biosynthetic process (GO:0006182)4.45131003
38heart trabecula formation (GO:0060347)4.44085736
39endothelial cell differentiation (GO:0045446)4.43808220
40stem cell development (GO:0048864)4.43574686
41positive regulation of odontogenesis (GO:0042482)4.40386294
42corticosteroid receptor signaling pathway (GO:0031958)4.39878082
43renal filtration (GO:0097205)4.38658041
44enteric nervous system development (GO:0048484)4.35167471
45ventricular septum morphogenesis (GO:0060412)4.34726476
46negative regulation of muscle contraction (GO:0045932)4.28611272
47aorta morphogenesis (GO:0035909)4.27256750
48sulfation (GO:0051923)4.25827460
49smooth muscle cell differentiation (GO:0051145)4.24290142
50positive regulation of neurotransmitter transport (GO:0051590)4.21662894
51relaxation of muscle (GO:0090075)4.19810302
52negative regulation of platelet activation (GO:0010544)4.17260479
53ATP synthesis coupled proton transport (GO:0015986)4.13154527
54energy coupled proton transport, down electrochemical gradient (GO:0015985)4.13154527
55tonic smooth muscle contraction (GO:0014820)4.11979852
56atrioventricular valve morphogenesis (GO:0003181)4.11042235
57positive regulation of amino acid transport (GO:0051957)4.10128790
58embryonic camera-type eye morphogenesis (GO:0048596)4.08128814
59negative regulation of striated muscle cell apoptotic process (GO:0010664)4.07408038
60cardiac muscle hypertrophy in response to stress (GO:0014898)4.00993937
61muscle hypertrophy in response to stress (GO:0003299)4.00993937
62cardiac muscle adaptation (GO:0014887)4.00993937
63head development (GO:0060322)3.98872277
64regulation of cardiac muscle cell apoptotic process (GO:0010665)3.95322758
65regulation of platelet aggregation (GO:0090330)3.94794712
66atrial septum morphogenesis (GO:0060413)3.94001285
67cell proliferation involved in metanephros development (GO:0072203)3.91950742
68ventricular cardiac muscle cell development (GO:0055015)3.89995627
69positive regulation of cardiac muscle tissue growth (GO:0055023)3.89742466
70cGMP-mediated signaling (GO:0019934)3.84674838
71regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.82684566
72metanephric mesenchyme development (GO:0072075)3.81467918
73cGMP metabolic process (GO:0046068)3.81134390
74dermatan sulfate biosynthetic process (GO:0030208)3.79267997
75negative regulation of transcription regulatory region DNA binding (GO:2000678)3.78406874
76negative regulation of vascular permeability (GO:0043116)3.73271629
77histamine transport (GO:0051608)3.71504215
78cardiac epithelial to mesenchymal transition (GO:0060317)3.71122684
79vascular endothelial growth factor signaling pathway (GO:0038084)3.70189637
80outflow tract morphogenesis (GO:0003151)3.69474470
81positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.65040638
82neural crest cell development (GO:0014032)3.59526933
83positive regulation of vascular permeability (GO:0043117)3.57002767
84positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.55432638
85negative regulation of smooth muscle contraction (GO:0045986)3.55216447
86positive regulation of cGMP biosynthetic process (GO:0030828)3.55207677
87positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.54794060
88somite development (GO:0061053)3.52233011
89cardiac ventricle morphogenesis (GO:0003208)3.51996530
90potassium ion import (GO:0010107)3.51511530
91positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.50424821
92positive regulation of heart contraction (GO:0045823)3.49860330
93positive regulation of heart growth (GO:0060421)3.49650800
94establishment of tissue polarity (GO:0007164)3.48484416
95establishment of planar polarity (GO:0001736)3.48484416
96purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.45883562
973-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.45883562
98positive regulation of smooth muscle cell migration (GO:0014911)3.45294564
99gap junction assembly (GO:0016264)3.45017962
100cell adhesion mediated by integrin (GO:0033627)3.41209659
101sodium ion export (GO:0071436)3.40274009
102regulation of endothelial cell chemotaxis (GO:2001026)3.39546193
103positive regulation of muscle hypertrophy (GO:0014742)3.39500614
104positive regulation of cardiac muscle hypertrophy (GO:0010613)3.39500614
105embryonic heart tube development (GO:0035050)3.37569732
106regulation of cilium movement (GO:0003352)3.35719475
107dermatan sulfate metabolic process (GO:0030205)3.34386022
108positive regulation of cardiac muscle tissue development (GO:0055025)3.33968992
109regulation of cGMP biosynthetic process (GO:0030826)3.33388231
110cardiac chamber morphogenesis (GO:0003206)3.32865080
111muscle cell proliferation (GO:0033002)3.31218561
112cell proliferation involved in kidney development (GO:0072111)3.29659998
113positive regulation of ERBB signaling pathway (GO:1901186)3.27400307
114artery smooth muscle contraction (GO:0014824)3.24984763
115establishment of protein localization to mitochondrial membrane (GO:0090151)3.24921573
116negative regulation of androgen receptor signaling pathway (GO:0060766)3.24415706
117positive regulation of cGMP metabolic process (GO:0030825)3.24408225
118relaxation of cardiac muscle (GO:0055119)3.23233943
119vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.22869188
120sodium-independent organic anion transport (GO:0043252)3.21947191
121positive regulation of cardiac muscle cell differentiation (GO:2000727)3.21645509
122labyrinthine layer blood vessel development (GO:0060716)3.21088333
123lymphangiogenesis (GO:0001946)3.20946104
124cardiac muscle hypertrophy (GO:0003300)3.20892649
125vasodilation (GO:0042311)3.19805354
126negative regulation of axon extension involved in axon guidance (GO:0048843)3.19540988
127cell surface receptor signaling pathway involved in heart development (GO:0061311)3.18815880
128artery morphogenesis (GO:0048844)3.17291718
129cyclic nucleotide metabolic process (GO:0009187)3.16506854
130positive regulation of cardiac muscle cell proliferation (GO:0060045)3.14061750
131regulation of cardiac muscle cell contraction (GO:0086004)3.10286151
132regulation of smooth muscle cell differentiation (GO:0051150)3.09401116
133phosphorelay signal transduction system (GO:0000160)3.09129267
134spinal cord development (GO:0021510)3.07198960
135heart valve morphogenesis (GO:0003179)3.07196666
136atrial cardiac muscle cell action potential (GO:0086014)3.02026923
137regulation of striated muscle cell apoptotic process (GO:0010662)3.01090196
138negative regulation of cell cycle arrest (GO:0071157)3.01075138
139cAMP catabolic process (GO:0006198)3.01063711
140striated muscle hypertrophy (GO:0014897)3.00805130
141cyclic nucleotide catabolic process (GO:0009214)3.00733037
142nephron epithelium development (GO:0072009)2.96739359
143negative regulation of Notch signaling pathway (GO:0045746)2.96619100
144negative regulation of muscle cell apoptotic process (GO:0010656)2.95752106
145embryonic digestive tract development (GO:0048566)2.95312920
146regulation of endothelial cell apoptotic process (GO:2000351)2.94232621
147trabecula formation (GO:0060343)2.93824966
148cyclic nucleotide biosynthetic process (GO:0009190)2.93549299
149positive regulation of actin filament depolymerization (GO:0030836)2.90603920
150regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)2.90269870
151vasculogenesis (GO:0001570)2.89854096
152notochord development (GO:0030903)2.89850958
153patterning of blood vessels (GO:0001569)2.87541628
154regulation of cGMP metabolic process (GO:0030823)2.87207963
155positive regulation of alcohol biosynthetic process (GO:1902932)2.86828051
156positive regulation of smooth muscle contraction (GO:0045987)2.83138189
157cochlea morphogenesis (GO:0090103)2.83113061
158cellular extravasation (GO:0045123)2.82815168
159membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.82020402
160cellular potassium ion homeostasis (GO:0030007)2.80268703
161cell morphogenesis involved in neuron differentiation (GO:0048667)2.79658752
162positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.79626341
163cyclic purine nucleotide metabolic process (GO:0052652)2.79030938
164positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)2.78899512
165peptidyl-tyrosine autophosphorylation (GO:0038083)2.77770688
166vascular smooth muscle contraction (GO:0014829)2.76126198
167peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.76093036
168cardiac muscle tissue development (GO:0048738)2.75275867
169dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.70964270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.65068461
2EED_16625203_ChIP-ChIP_MESCs_Mouse3.16194670
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07079521
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.06170696
5SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.83403193
6EZH2_22144423_ChIP-Seq_EOC_Human2.81585825
7SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.75026861
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70620263
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68187358
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.54917464
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.52092908
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40063627
13TAF15_26573619_Chip-Seq_HEK293_Human2.39975821
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37900111
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.37577146
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.34854662
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.34854662
18GBX2_23144817_ChIP-Seq_PC3_Human2.30870515
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29366701
20PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.26628481
21RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.17073577
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12577919
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07784364
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04075867
25CBX2_27304074_Chip-Seq_ESCs_Mouse2.02791527
26EWS_26573619_Chip-Seq_HEK293_Human1.96705286
27IGF1R_20145208_ChIP-Seq_DFB_Human1.94404132
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.91471698
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90977753
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.87786310
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86783480
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86579859
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.84821787
34ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.78540105
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.72758983
36EP300_21415370_ChIP-Seq_HL-1_Mouse1.64422257
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62514286
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60991556
39AR_21572438_ChIP-Seq_LNCaP_Human1.56244568
40FUS_26573619_Chip-Seq_HEK293_Human1.52379958
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51753285
42BCAT_22108803_ChIP-Seq_LS180_Human1.50951967
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50227319
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49546307
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48785000
46CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48729603
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.46955565
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46215906
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41734447
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.40616262
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.40568376
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37533545
53ER_23166858_ChIP-Seq_MCF-7_Human1.35309089
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.35217870
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34823400
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34614849
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34547582
58VDR_22108803_ChIP-Seq_LS180_Human1.34439167
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.30572168
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.30366296
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29899354
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.28351191
63AHR_22903824_ChIP-Seq_MCF-7_Human1.26060446
64ZNF274_21170338_ChIP-Seq_K562_Hela1.25981559
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25235478
66DROSHA_22980978_ChIP-Seq_HELA_Human1.24351546
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.22568305
68NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22022503
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22022503
70TP53_16413492_ChIP-PET_HCT116_Human1.21795396
71CJUN_26792858_Chip-Seq_BT549_Human1.21505960
72TP53_18474530_ChIP-ChIP_U2OS_Human1.21473679
73RNF2_27304074_Chip-Seq_NSC_Mouse1.20865981
74SMAD4_21799915_ChIP-Seq_A2780_Human1.18692463
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17135441
76P300_19829295_ChIP-Seq_ESCs_Human1.17111060
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16258847
78TP63_17297297_ChIP-ChIP_HaCaT_Human1.14036006
79EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13119035
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11652530
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.10386960
82P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10288338
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09210416
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09066819
85TP53_20018659_ChIP-ChIP_R1E_Mouse1.08710665
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08584999
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08069513
88TCF4_18268006_ChIP-ChIP_LS174T_Human1.07786037
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07023124
90KDM2B_26808549_Chip-Seq_REH_Human1.06911983
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04326069
92CBP_20019798_ChIP-Seq_JUKART_Human1.04326069
93ISL1_27105846_Chip-Seq_CPCs_Mouse1.04015531
94STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01409544
95ESR1_21235772_ChIP-Seq_MCF-7_Human1.01189154
96CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00817691
97SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99249354
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98723284
99WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98473891
100ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97559657
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97480771
102ESR1_20079471_ChIP-ChIP_T-47D_Human0.97467436
103POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97098852
104AR_25329375_ChIP-Seq_VCAP_Human0.97069123
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95915042
106TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95558476
107RXR_22108803_ChIP-Seq_LS180_Human0.95364378
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95323407
109IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94944801
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94370825
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94069856
112FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93994650
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93111560
114TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91267458
115RUNX2_22187159_ChIP-Seq_PCA_Human0.90964141
116MYC_27129775_Chip-Seq_CORNEA_Mouse0.89451554
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89114118
118TBL1_22424771_ChIP-Seq_293T_Human0.88060214
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87868993
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87594069
121SMAD4_21741376_ChIP-Seq_EPCs_Human0.87532421
122TBX3_20139965_ChIP-Seq_ESCs_Mouse0.87401647
123KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86515946
124SMAD3_21741376_ChIP-Seq_HESCs_Human0.86460104
125KLF4_19829295_ChIP-Seq_ESCs_Human0.86026475
126FLI1_21867929_ChIP-Seq_TH2_Mouse0.85386463
127TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85286911
128LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84870839
129SOX2_21211035_ChIP-Seq_LN229_Gbm0.83436369
130LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81806087
131REST_21632747_ChIP-Seq_MESCs_Mouse0.81124565

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009384_cardiac_valve_regurgitation7.43412706
2MP0002009_preneoplasia4.91402813
3MP0001879_abnormal_lymphatic_vessel4.23983640
4MP0005623_abnormal_meninges_morphology4.09507197
5MP0004272_abnormal_basement_membrane3.60317862
6MP0001986_abnormal_taste_sensitivity3.44614861
7MP0005167_abnormal_blood-brain_barrier3.36350284
8MP0010368_abnormal_lymphatic_system3.10278468
9MP0002127_abnormal_cardiovascular_syste2.97825362
10MP0004215_abnormal_myocardial_fiber2.84315125
11MP0000516_abnormal_urinary_system2.73180693
12MP0005367_renal/urinary_system_phenotyp2.73180693
13MP0005084_abnormal_gallbladder_morpholo2.65709187
14MP0006138_congestive_heart_failure2.37095112
15MP0003950_abnormal_plasma_membrane2.28350528
16MP0001485_abnormal_pinna_reflex2.18145399
17MP0003283_abnormal_digestive_organ2.14648606
18MP0003279_aneurysm2.13736366
19MP0004085_abnormal_heartbeat2.12902518
20MP0005330_cardiomyopathy2.11364217
21MP0004484_altered_response_of2.09833010
22MP0001346_abnormal_lacrimal_gland2.05081886
23MP0005620_abnormal_muscle_contractility1.98192368
24MP0002972_abnormal_cardiac_muscle1.95511383
25MP0002938_white_spotting1.93700482
26MP0003880_abnormal_central_pattern1.89606033
27MP0004147_increased_porphyrin_level1.85750574
28MP0002166_altered_tumor_susceptibility1.85362642
29MP0000534_abnormal_ureter_morphology1.79235559
30MP0005165_increased_susceptibility_to1.76704414
31MP0009379_abnormal_foot_pigmentation1.73266229
32MP0004130_abnormal_muscle_cell1.72649177
33MP0000462_abnormal_digestive_system1.71932880
34MP0008569_lethality_at_weaning1.69742308
35MP0000767_abnormal_smooth_muscle1.69158821
36MP0003119_abnormal_digestive_system1.68963003
37MP0003136_yellow_coat_color1.67962766
38MP0009053_abnormal_anal_canal1.67706001
39MP0000762_abnormal_tongue_morphology1.66270027
40MP0005164_abnormal_response_to1.61967662
41MP0005595_abnormal_vascular_smooth1.56987357
42MP0004742_abnormal_vestibular_system1.50285839
43MP0003828_pulmonary_edema1.46741245
44MP0001664_abnormal_digestion1.44461605
45MP0000537_abnormal_urethra_morphology1.42979335
46MP0004883_abnormal_blood_vessel1.41139505
47MP0001270_distended_abdomen1.39354156
48MP0004036_abnormal_muscle_relaxation1.35702639
49MP0004084_abnormal_cardiac_muscle1.35204495
50MP0002909_abnormal_adrenal_gland1.35027939
51MP0002295_abnormal_pulmonary_circulatio1.35015537
52MP0010630_abnormal_cardiac_muscle1.34884960
53MP0003011_delayed_dark_adaptation1.32646411
54MP0001968_abnormal_touch/_nociception1.30821371
55MP0000538_abnormal_urinary_bladder1.30134193
56MP0000751_myopathy1.23638570
57MP0002332_abnormal_exercise_endurance1.22952019
58MP0000249_abnormal_blood_vessel1.22853820
59MP0002282_abnormal_trachea_morphology1.22166752
60MP0003724_increased_susceptibility_to1.22122140
61MP0003635_abnormal_synaptic_transmissio1.20038920
62MP0005174_abnormal_tail_pigmentation1.18795099
63MP0004133_heterotaxia1.17953201
64MP0001544_abnormal_cardiovascular_syste1.17411471
65MP0005385_cardiovascular_system_phenoty1.17411471
66MP0003137_abnormal_impulse_conducting1.16480241
67MP0009250_abnormal_appendicular_skeleto1.15911312
68MP0002733_abnormal_thermal_nociception1.13561894
69MP0002928_abnormal_bile_duct1.12703328
70MP0001970_abnormal_pain_threshold1.11940699
71MP0002396_abnormal_hematopoietic_system1.10102626
72MP0001324_abnormal_eye_pigmentation1.08816446
73MP0002006_tumorigenesis1.08543203
74MP0005423_abnormal_somatic_nervous1.08422711
75MP0002108_abnormal_muscle_morphology1.08205023
76MP0002822_catalepsy1.06721055
77MP0000230_abnormal_systemic_arterial1.02511689
78MP0005645_abnormal_hypothalamus_physiol1.02298156
79MP0004145_abnormal_muscle_electrophysio1.01642675
80MP0005503_abnormal_tendon_morphology1.00114666
81MP0006054_spinal_hemorrhage0.98352030
82MP0004885_abnormal_endolymph0.97847504
83MP0002925_abnormal_cardiovascular_devel0.96057756
84MP0000470_abnormal_stomach_morphology0.94645684
85MP0003941_abnormal_skin_development0.94036228
86MP0000749_muscle_degeneration0.93541820
87MP0002128_abnormal_blood_circulation0.93430321
88MP0002735_abnormal_chemical_nociception0.93113763
89MP0001614_abnormal_blood_vessel0.92746550
90MP0005408_hypopigmentation0.92189893
91MP0001486_abnormal_startle_reflex0.90142797
92MP0009745_abnormal_behavioral_response0.89840016
93MP0000026_abnormal_inner_ear0.89060005
94MP0002160_abnormal_reproductive_system0.88253534
95MP0008775_abnormal_heart_ventricle0.88087973
96MP0002933_joint_inflammation0.87530163
97MP0002249_abnormal_larynx_morphology0.86322355
98MP0005187_abnormal_penis_morphology0.86077785
99MP0000163_abnormal_cartilage_morphology0.84266238
100MP0003755_abnormal_palate_morphology0.82840626
101MP0009697_abnormal_copulation0.82359412
102MP0003195_calcinosis0.82222623
103MP0003633_abnormal_nervous_system0.82119848
104MP0002064_seizures0.81733589
105MP0002572_abnormal_emotion/affect_behav0.80545476
106MP0000343_altered_response_to0.79947866
107MP0005551_abnormal_eye_electrophysiolog0.79747143
108MP0003935_abnormal_craniofacial_develop0.77562815
109MP0002837_dystrophic_cardiac_calcinosis0.76845002
110MP0003075_altered_response_to0.75860497
111MP0000631_abnormal_neuroendocrine_gland0.75531643
112MP0003942_abnormal_urinary_system0.75103832
113MP0004270_analgesia0.74294763
114MP0005195_abnormal_posterior_eye0.74096016
115MP0004087_abnormal_muscle_fiber0.73791488
116MP0003045_fibrosis0.73323861
117MP0001502_abnormal_circadian_rhythm0.73128697
118MP0001851_eye_inflammation0.71652432
119MP0008961_abnormal_basal_metabolism0.71559621
120MP0003122_maternal_imprinting0.71441035
121MP0002272_abnormal_nervous_system0.71132919
122MP0001661_extended_life_span0.69837119
123MP0006276_abnormal_autonomic_nervous0.69427222
124MP0001440_abnormal_grooming_behavior0.68690560
125MP0004859_abnormal_synaptic_plasticity0.68649620
126MP0003091_abnormal_cell_migration0.67469041
127MP0002090_abnormal_vision0.66812716
128MP0003300_gastrointestinal_ulcer0.66803078
129MP0000778_abnormal_nervous_system0.65885218
130MP0000920_abnormal_myelination0.65248247
131MP0009780_abnormal_chondrocyte_physiolo0.64775080
132MP0003631_nervous_system_phenotype0.64726304
133MP0000049_abnormal_middle_ear0.64609126
134MP0003638_abnormal_response/metabolism_0.63139015
135MP0003787_abnormal_imprinting0.62791927
136MP0002063_abnormal_learning/memory/cond0.62520787
137MP0001905_abnormal_dopamine_level0.61886185
138MP0005253_abnormal_eye_physiology0.61092927
139MP0002736_abnormal_nociception_after0.60695508
140MP0005388_respiratory_system_phenotype0.60573979
141MP0002133_abnormal_respiratory_system0.60573979
142MP0006072_abnormal_retinal_apoptosis0.58912464
143MP0002734_abnormal_mechanical_nocicepti0.57822396
144MP0002254_reproductive_system_inflammat0.56208480
145MP0005171_absent_coat_pigmentation0.56190966
146MP0000266_abnormal_heart_morphology0.55591329

Predicted human phenotypes

RankGene SetZ-score
1Short hallux (HP:0010109)6.47247658
2Aplasia/Hypoplasia of the hallux (HP:0008362)5.95049229
3Axonal loss (HP:0003447)5.79407538
4Posterior subcapsular cataract (HP:0007787)5.19546712
5Ulnar claw (HP:0001178)4.39455951
6Congenital, generalized hypertrichosis (HP:0004540)4.39278261
7Depressed nasal tip (HP:0000437)4.08399280
8Pulmonary artery stenosis (HP:0004415)4.07771918
9Nausea (HP:0002018)3.95796279
10Focal segmental glomerulosclerosis (HP:0000097)3.85993624
11Hemiparesis (HP:0001269)3.82743499
12Hydroureter (HP:0000072)3.78542898
13Spastic tetraparesis (HP:0001285)3.73941290
14Metaphyseal dysplasia (HP:0100255)3.69397353
15Spontaneous abortion (HP:0005268)3.68339257
16Atonic seizures (HP:0010819)3.52501996
17Polycythemia (HP:0001901)3.52202946
18Aortic aneurysm (HP:0004942)3.46997803
19Absent hand (HP:0004050)3.44342144
20Mesangial abnormality (HP:0001966)3.43895051
21Midline defect of the nose (HP:0004122)3.43581840
22Absent toe (HP:0010760)3.33778153
23Calf muscle hypertrophy (HP:0008981)3.30759507
24Opisthotonus (HP:0002179)3.30588730
25Aortic dissection (HP:0002647)3.28214507
26Abnormality of binocular vision (HP:0011514)3.26064889
27Diplopia (HP:0000651)3.26064889
28Hypoplasia of the iris (HP:0007676)3.26020175
29Anencephaly (HP:0002323)3.18693427
30Cerebral hemorrhage (HP:0001342)3.14925458
31Hypoplastic ischia (HP:0003175)3.13557913
32Broad metatarsal (HP:0001783)3.08552193
33Adactyly (HP:0009776)3.03847981
34Venous insufficiency (HP:0005293)3.03553066
35Subcapsular cataract (HP:0000523)3.03278838
36Muscle hypertrophy of the lower extremities (HP:0008968)3.01798318
37Amelogenesis imperfecta (HP:0000705)3.01777903
38Subacute progressive viral hepatitis (HP:0006572)2.99731777
39Abnormality of the ischium (HP:0003174)2.96329866
40Stenosis of the external auditory canal (HP:0000402)2.91564867
41Polyuria (HP:0000103)2.90872865
42Focal seizures (HP:0007359)2.88097511
43Accelerated skeletal maturation (HP:0005616)2.86652775
44Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.86024748
45True hermaphroditism (HP:0010459)2.84879429
46Scotoma (HP:0000575)2.83143414
47Hyperventilation (HP:0002883)2.79919736
48Abnormality of the pubic bones (HP:0003172)2.75471972
49Basal ganglia calcification (HP:0002135)2.75461793
50Ventricular tachycardia (HP:0004756)2.74853111
51Intestinal atresia (HP:0011100)2.73378217
52Glomerulosclerosis (HP:0000096)2.72315041
53Retinal dysplasia (HP:0007973)2.70326274
54Prominent supraorbital ridges (HP:0000336)2.69476074
55Exercise-induced muscle cramps (HP:0003710)2.67646831
56Preaxial foot polydactyly (HP:0001841)2.65089975
57Aplasia/Hypoplasia involving the musculature (HP:0001460)2.58125393
58Chorioretinal atrophy (HP:0000533)2.56564059
59Hypoglycemic coma (HP:0001325)2.55925382
60Abnormal drinking behavior (HP:0030082)2.52287676
61Polydipsia (HP:0001959)2.52287676
62Hyperinsulinemic hypoglycemia (HP:0000825)2.50322351
63Abnormality of the calf musculature (HP:0001430)2.49993124
64Abnormal urine output (HP:0012590)2.49701224
65Epileptic encephalopathy (HP:0200134)2.48670232
66Bone cyst (HP:0012062)2.43236504
67Confusion (HP:0001289)2.42594054
68Aplasia cutis congenita (HP:0001057)2.42568508
69Abnormality of Sharpey fibers (HP:0100685)2.40515614
70Pancreatic islet-cell hyperplasia (HP:0004510)2.38685180
71Chondrocalcinosis (HP:0000934)2.36372039
72Dysdiadochokinesis (HP:0002075)2.36189128
73Focal motor seizures (HP:0011153)2.35398106
74Esophageal varix (HP:0002040)2.34262013
75Large for gestational age (HP:0001520)2.32241645
76Abnormality of cells of the erythroid lineage (HP:0012130)2.30915749
77Abnormality of the left ventricular outflow tract (HP:0011103)2.29523210
78Subaortic stenosis (HP:0001682)2.29523210
79Anterior segment dysgenesis (HP:0007700)2.29358279
80Abnormality of the vitreous humor (HP:0004327)2.29029530
81Venous abnormality (HP:0002624)2.28937601
82Hypoplastic left heart (HP:0004383)2.27938426
83Abnormality of the phalanges of the 2nd finger (HP:0009541)2.24692898
84Hypoplastic nipples (HP:0002557)2.24305756
85Stage 5 chronic kidney disease (HP:0003774)2.23871725
86Hypoglycemic seizures (HP:0002173)2.22616407
87Hemiplegia (HP:0002301)2.21000918
88Pancreatic fibrosis (HP:0100732)2.19874915
89Generalized tonic-clonic seizures (HP:0002069)2.17110793
90Abnormality of the vertebral endplates (HP:0005106)2.16616658
91Arterial tortuosity (HP:0005116)2.14564499
92Spastic paraparesis (HP:0002313)2.13771492
93Abnormality of the columella (HP:0009929)2.13344498
94Conjugated hyperbilirubinemia (HP:0002908)2.11315678
95Segmental peripheral demyelination/remyelination (HP:0003481)2.11110494
96Peripheral hypomyelination (HP:0007182)2.09998956
97Overgrowth (HP:0001548)2.09847032
98Vascular calcification (HP:0004934)2.08832674
99Sudden death (HP:0001699)2.08431088
100Abnormal number of erythroid precursors (HP:0012131)2.08272524
101Hypercortisolism (HP:0001578)2.08079622
102Furrowed tongue (HP:0000221)2.07375437
103Abnormality of renal excretion (HP:0011036)2.03848142
104Abnormality of secondary sexual hair (HP:0009888)2.00509847
105Abnormality of the axillary hair (HP:0100134)2.00509847
106Polar cataract (HP:0010696)1.99537073
107Atrial fibrillation (HP:0005110)1.97430352
108Muscle stiffness (HP:0003552)1.96440574
109Abnormal hemoglobin (HP:0011902)1.96274429
110Multiple lipomas (HP:0001012)1.95879318
111Limb dystonia (HP:0002451)1.95694141
112Lower limb hyperreflexia (HP:0002395)1.95259716
113Gastrointestinal atresia (HP:0002589)1.94723322
114Severe Myopia (HP:0011003)1.93216920
115Viral hepatitis (HP:0006562)1.92818393
116Bilateral microphthalmos (HP:0007633)1.92548017
117Back pain (HP:0003418)1.91762499
118Hyperlipoproteinemia (HP:0010980)1.91480990
119Vascular tortuosity (HP:0004948)1.90945081
120Decreased circulating renin level (HP:0003351)1.90453353
121Migraine (HP:0002076)1.90232076
122Low anterior hairline (HP:0000294)1.90045541
123Gingival overgrowth (HP:0000212)1.89888848
124Bicuspid aortic valve (HP:0001647)1.89702058
125Exertional dyspnea (HP:0002875)1.89183487
126Synostosis involving the elbow (HP:0003938)1.89029646
127Humeroradial synostosis (HP:0003041)1.89029646
128Abnormality of dentin (HP:0010299)1.88566841
129Supraventricular arrhythmia (HP:0005115)1.88469032
130Ectopia lentis (HP:0001083)1.87800330
131Diastasis recti (HP:0001540)1.86018997
132Short distal phalanx of finger (HP:0009882)1.85702618
133Hypercalcemia (HP:0003072)1.85019581
134Molar tooth sign on MRI (HP:0002419)1.84872022
135Abnormality of midbrain morphology (HP:0002418)1.84872022
136Primary atrial arrhythmia (HP:0001692)1.84868519
137Aplasia of the musculature (HP:0100854)1.83841393
138Benign neoplasm of the central nervous system (HP:0100835)1.83217556
139Neurofibrillary tangles (HP:0002185)1.81334714
140Abnormality of calcium-phosphate metabolism (HP:0100530)1.81333913
141Abnormality of the right ventricle (HP:0001707)1.80909969
142Myelomeningocele (HP:0002475)1.78756739
143Cardiovascular calcification (HP:0011915)1.78666047
144Abnormality of the sella turcica (HP:0002679)1.78478874
145Abnormality of sulfur amino acid metabolism (HP:0004339)1.77987998
146Epidermoid cyst (HP:0200040)1.77750058
147Sensory axonal neuropathy (HP:0003390)1.77738777
148Peripheral demyelination (HP:0011096)1.77510440
149Vertebral arch anomaly (HP:0008438)1.77233232
150Amblyopia (HP:0000646)1.76281925
151Trigonocephaly (HP:0000243)1.76097450
152Aplasia/Hypoplasia of the sacrum (HP:0008517)1.75914726
153Skull defect (HP:0001362)1.75905458
154Agitation (HP:0000713)1.75452186
155Supraventricular tachycardia (HP:0004755)1.75065665
156Constricted visual fields (HP:0001133)1.74480218
157Abnormality of the anterior chamber (HP:0000593)1.73711872
158Hypoplastic heart (HP:0001961)1.73063726
159Broad nasal tip (HP:0000455)1.72683884
160Male infertility (HP:0003251)1.72146825
161Portal hypertension (HP:0001409)1.71561857
162Dialeptic seizures (HP:0011146)1.71381999
163Concave nail (HP:0001598)1.71289416
164Scanning speech (HP:0002168)1.70939516
165Bundle branch block (HP:0011710)1.70790035
166Pulmonary hypertension (HP:0002092)1.70779421
167Palpebral edema (HP:0100540)1.69409596
168Paralysis (HP:0003470)1.69094854
169Absence seizures (HP:0002121)1.68372861
170Short tibia (HP:0005736)1.68045717
171Cerebral aneurysm (HP:0004944)1.67684134
172Annular pancreas (HP:0001734)1.67488406

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK7.29184853
2MYLK6.75196253
3WEE14.90718725
4MAP3K104.63618418
5MST44.07373369
6NUAK13.97401835
7TIE13.23569879
8TSSK62.74450716
9AKT32.72453409
10PAK22.62078506
11DMPK2.59736217
12VRK12.14718344
13KDR2.11279866
14PAK32.09723534
15PTK2B2.00759768
16STK392.00730819
17ZAK1.87565816
18FRK1.77681981
19VRK21.75799576
20MARK21.68994018
21EPHA41.64903581
22PDGFRA1.58036800
23DAPK31.44177869
24MAP3K121.41909264
25ADRBK11.38179796
26RAF11.36880478
27MAP3K21.36084524
28GRK11.34021382
29MAPK151.31437571
30INSRR1.31055394
31PRKD11.26364670
32TAOK11.25007598
33CDC42BPA1.24965211
34NTRK31.17837353
35CASK1.17101838
36PRKCE1.16145251
37MAPKAPK51.15352091
38EPHB21.13982144
39FES1.13272632
40TGFBR21.10835472
41NTRK21.08693962
42TAF11.06256867
43OXSR11.02466575
44KIT1.01713945
45ROCK10.95201350
46PRKAA20.95145973
47ABL20.93696832
48PRKG20.93621048
49PDK20.93418368
50MAPK130.92670525
51FGR0.91401596
52DYRK1B0.87866131
53ITK0.87793636
54MAPK120.87086344
55IRAK20.86628268
56FGFR20.84892238
57CAMK10.84510393
58DAPK20.82796653
59YES10.79989156
60MAP2K10.79415731
61IRAK40.78869355
62CDK30.78241344
63TNIK0.77948349
64ADRBK20.76601141
65IRAK10.76433554
66CAMK2A0.75422637
67OBSCN0.74878811
68PIM20.74307539
69WNK40.73054383
70TTN0.70115261
71MAPK70.69343141
72RET0.69130486
73PRKCG0.67787996
74INSR0.67603478
75MET0.66700585
76PRKCQ0.65498731
77DYRK30.64782758
78BCR0.64436469
79CSK0.64114376
80GRK50.63866674
81PAK60.62864565
82TGFBR10.62287508
83CDK120.61211217
84PRKG10.59462832
85MARK10.58344188
86IKBKE0.57233072
87PHKG10.56672628
88PHKG20.56672628
89MAP2K20.56116346
90PRKACA0.56011791
91PDGFRB0.54691287
92MAP2K40.54526104
93GSK3A0.54210947
94ILK0.53470217
95PTK20.50496766
96CDK50.49686109
97RPS6KA50.49612108
98TEC0.48905400
99IGF1R0.47459569
100PRKACB0.47233627
101ROCK20.47199120
102MINK10.46820807
103PRKCA0.46499310
104CDK60.46364987
105PRKCH0.45812670
106NLK0.45458038
107STK110.45220545
108CAMK2G0.44907082
109PASK0.44836635
110PIK3CG0.44741802
111STK380.44004733
112TLK10.43743374
113MAPK40.43536542
114UHMK10.42790386
115FYN0.42773090
116ERBB40.42414959
117RPS6KA60.42349450
118BMPR20.42058922
119CAMK2D0.41419869
120CAMK1G0.40971408
121PKN10.40405774
122PBK0.39948559
123PLK20.39328351
124MUSK0.38363903
125RPS6KA30.37593826
126TBK10.37150160
127KSR20.36793946
128DDR20.36493657
129SRC0.36312919
130CAMK2B0.35969192
131CDK80.35859120
132CDC70.35727045
133DYRK1A0.35718761
134NEK20.35388516
135BRSK20.35322521
136STK240.34809525
137RIPK40.34582311
138LYN0.34105073
139CAMK1D0.33874507
140NTRK10.33234446
141MAP3K30.28670818
142NME10.28504607
143RPS6KC10.27002830
144RPS6KL10.27002830
145MKNK20.26308789
146RPS6KA10.23789070

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041224.19933419
2Folate biosynthesis_Homo sapiens_hsa007903.04421679
3Renin secretion_Homo sapiens_hsa049242.74536316
4Vascular smooth muscle contraction_Homo sapiens_hsa042702.51720456
5Ribosome_Homo sapiens_hsa030102.40723416
6Dilated cardiomyopathy_Homo sapiens_hsa054142.36961689
7Morphine addiction_Homo sapiens_hsa050322.20613644
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.14307197
9GABAergic synapse_Homo sapiens_hsa047272.13283522
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.08550985
11cGMP-PKG signaling pathway_Homo sapiens_hsa040222.01854062
12Cardiac muscle contraction_Homo sapiens_hsa042602.00898173
13Circadian entrainment_Homo sapiens_hsa047131.93700642
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.85652737
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.80675493
16ECM-receptor interaction_Homo sapiens_hsa045121.79627949
17Salivary secretion_Homo sapiens_hsa049701.78377534
18Oxytocin signaling pathway_Homo sapiens_hsa049211.76951817
19Glutamatergic synapse_Homo sapiens_hsa047241.74580445
20Focal adhesion_Homo sapiens_hsa045101.73436402
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.63455068
22Serotonergic synapse_Homo sapiens_hsa047261.63291903
23cAMP signaling pathway_Homo sapiens_hsa040241.62261157
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.56852251
25Gap junction_Homo sapiens_hsa045401.53428769
26Bile secretion_Homo sapiens_hsa049761.51005032
27Nicotine addiction_Homo sapiens_hsa050331.44810911
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42731504
29Calcium signaling pathway_Homo sapiens_hsa040201.41681106
30Linoleic acid metabolism_Homo sapiens_hsa005911.41155930
31Phototransduction_Homo sapiens_hsa047441.40679029
32Oxidative phosphorylation_Homo sapiens_hsa001901.39881027
33Estrogen signaling pathway_Homo sapiens_hsa049151.34988897
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34601455
35Axon guidance_Homo sapiens_hsa043601.32672966
36Alzheimers disease_Homo sapiens_hsa050101.26131745
37Insulin secretion_Homo sapiens_hsa049111.23895390
38Adherens junction_Homo sapiens_hsa045201.21688080
39Cholinergic synapse_Homo sapiens_hsa047251.19873011
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18896080
41Rap1 signaling pathway_Homo sapiens_hsa040151.17602784
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.17209623
43Gastric acid secretion_Homo sapiens_hsa049711.16315632
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.12867958
45Notch signaling pathway_Homo sapiens_hsa043301.12748077
46Ras signaling pathway_Homo sapiens_hsa040141.10659368
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09419172
48Collecting duct acid secretion_Homo sapiens_hsa049661.09275338
49Long-term depression_Homo sapiens_hsa047301.06891994
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.06237746
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.02924271
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02651489
53Nitrogen metabolism_Homo sapiens_hsa009101.01684547
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01171104
55Phospholipase D signaling pathway_Homo sapiens_hsa040721.00279296
56Complement and coagulation cascades_Homo sapiens_hsa046100.99587611
57Platelet activation_Homo sapiens_hsa046110.99518532
58Parkinsons disease_Homo sapiens_hsa050120.99197072
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98407954
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98018472
61Dorso-ventral axis formation_Homo sapiens_hsa043200.96080222
62Melanogenesis_Homo sapiens_hsa049160.95478302
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94257179
64Long-term potentiation_Homo sapiens_hsa047200.93644405
65Protein digestion and absorption_Homo sapiens_hsa049740.93279807
66Taste transduction_Homo sapiens_hsa047420.93185989
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92950334
68Ovarian steroidogenesis_Homo sapiens_hsa049130.91765331
69Dopaminergic synapse_Homo sapiens_hsa047280.91641211
70Amphetamine addiction_Homo sapiens_hsa050310.90741215
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89932153
72ABC transporters_Homo sapiens_hsa020100.87567562
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87247855
74Renal cell carcinoma_Homo sapiens_hsa052110.87115242
75Rheumatoid arthritis_Homo sapiens_hsa053230.80304469
76Thyroid hormone synthesis_Homo sapiens_hsa049180.80054404
77Tight junction_Homo sapiens_hsa045300.78942066
78Selenocompound metabolism_Homo sapiens_hsa004500.78801924
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78333149
80Proteoglycans in cancer_Homo sapiens_hsa052050.77563877
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75289402
82Amoebiasis_Homo sapiens_hsa051460.74321734
83African trypanosomiasis_Homo sapiens_hsa051430.73317507
84Choline metabolism in cancer_Homo sapiens_hsa052310.72360552
85Tryptophan metabolism_Homo sapiens_hsa003800.71820496
86MAPK signaling pathway_Homo sapiens_hsa040100.71792612
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.70882823
88Mineral absorption_Homo sapiens_hsa049780.70623413
89Pancreatic secretion_Homo sapiens_hsa049720.69622846
90Arginine biosynthesis_Homo sapiens_hsa002200.68875585
91Huntingtons disease_Homo sapiens_hsa050160.68650850
92Basal cell carcinoma_Homo sapiens_hsa052170.68335929
93Sulfur metabolism_Homo sapiens_hsa009200.66824637
94Chemical carcinogenesis_Homo sapiens_hsa052040.66191263
95Fatty acid biosynthesis_Homo sapiens_hsa000610.64863170
96Inositol phosphate metabolism_Homo sapiens_hsa005620.64416743
97TGF-beta signaling pathway_Homo sapiens_hsa043500.63449700
98Purine metabolism_Homo sapiens_hsa002300.62639795
99GnRH signaling pathway_Homo sapiens_hsa049120.62582089
100Melanoma_Homo sapiens_hsa052180.62427848
101Small cell lung cancer_Homo sapiens_hsa052220.62338643
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59248090
103Phenylalanine metabolism_Homo sapiens_hsa003600.58519446
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57911738
105Cocaine addiction_Homo sapiens_hsa050300.57689530
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57608248
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57522733
108Pathways in cancer_Homo sapiens_hsa052000.56095343
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55622745
110Histidine metabolism_Homo sapiens_hsa003400.54870546
111Caffeine metabolism_Homo sapiens_hsa002320.53799306
112Arachidonic acid metabolism_Homo sapiens_hsa005900.51766303
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49619708
114Arginine and proline metabolism_Homo sapiens_hsa003300.47221863
115Wnt signaling pathway_Homo sapiens_hsa043100.46474042
116Ether lipid metabolism_Homo sapiens_hsa005650.45560107
117VEGF signaling pathway_Homo sapiens_hsa043700.42282084
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42078943
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41346070
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41275212
121HIF-1 signaling pathway_Homo sapiens_hsa040660.40957420
122Vitamin digestion and absorption_Homo sapiens_hsa049770.39835333
123Glutathione metabolism_Homo sapiens_hsa004800.39780333
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38943540
125Hippo signaling pathway_Homo sapiens_hsa043900.37754958
126Prion diseases_Homo sapiens_hsa050200.36834353
127Olfactory transduction_Homo sapiens_hsa047400.36166516
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30470552
129Fanconi anemia pathway_Homo sapiens_hsa034600.29738883
130Butanoate metabolism_Homo sapiens_hsa006500.23697276

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