HIGD1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)8.94715456
2diacylglycerol metabolic process (GO:0046339)8.54560579
3behavioral response to nicotine (GO:0035095)8.41856137
4dopaminergic neuron differentiation (GO:0071542)8.35425739
5cellular response to prostaglandin stimulus (GO:0071379)8.22935674
6body morphogenesis (GO:0010171)7.83038510
7ganglion development (GO:0061548)7.47851432
8enteric nervous system development (GO:0048484)7.06351873
9post-embryonic morphogenesis (GO:0009886)6.73604677
10cellular response to zinc ion (GO:0071294)6.58057280
11cell migration in hindbrain (GO:0021535)6.55930763
12positive regulation of cAMP-mediated signaling (GO:0043950)6.35860918
13regulation of respiratory gaseous exchange (GO:0043576)6.27656427
14adrenergic receptor signaling pathway (GO:0071875)6.21324667
15cAMP biosynthetic process (GO:0006171)6.08972502
16response to prostaglandin E (GO:0034695)6.08184365
17negative regulation of multicellular organism growth (GO:0040015)6.03554824
18ectodermal placode formation (GO:0060788)5.81379269
19norepinephrine metabolic process (GO:0042415)5.75172511
20regulation of non-canonical Wnt signaling pathway (GO:2000050)5.65275135
21regulation of respiratory gaseous exchange by neurological system process (GO:0002087)5.43099215
22surfactant homeostasis (GO:0043129)5.21794232
23alkaloid metabolic process (GO:0009820)5.17445217
24dopamine biosynthetic process (GO:0042416)4.92567586
25synaptic transmission, cholinergic (GO:0007271)4.84757060
26primary amino compound metabolic process (GO:1901160)4.73849634
27regulation of cardioblast proliferation (GO:0003264)4.57671696
28regulation of secondary heart field cardioblast proliferation (GO:0003266)4.57671696
29response to prostaglandin (GO:0034694)4.56312758
30activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)4.51936571
31cellular response to catecholamine stimulus (GO:0071870)4.51440110
32cellular response to monoamine stimulus (GO:0071868)4.51440110
33neuronal action potential propagation (GO:0019227)4.44096680
34protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)4.43950272
35regulation of respiratory system process (GO:0044065)4.42628200
36cellular response to BMP stimulus (GO:0071773)4.25841539
37response to BMP (GO:0071772)4.25841539
38negative regulation of calcium ion transport into cytosol (GO:0010523)4.21635017
39negative regulation of cytosolic calcium ion concentration (GO:0051481)4.12327247
40negative regulation of cell cycle arrest (GO:0071157)4.10333659
41catechol-containing compound biosynthetic process (GO:0009713)4.07397163
42catecholamine biosynthetic process (GO:0042423)4.07397163
43chemical homeostasis within a tissue (GO:0048875)3.99085763
44dopamine receptor signaling pathway (GO:0007212)3.98537876
45cellular response to glucagon stimulus (GO:0071377)3.98304026
46calcium-mediated signaling using intracellular calcium source (GO:0035584)3.98160149
47regulation of axon regeneration (GO:0048679)3.89452740
48regulation of neuron projection regeneration (GO:0070570)3.89452740
49negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.83534839
50response to catecholamine (GO:0071869)3.79071383
51response to monoamine (GO:0071867)3.79071383
52positive regulation of cell cycle G2/M phase transition (GO:1902751)3.77797607
53positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.77797607
54coronary vasculature morphogenesis (GO:0060977)3.70419452
55cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.70006348
56neural crest cell migration (GO:0001755)3.69138867
57organic cation transport (GO:0015695)3.64095516
58positive regulation of osteoclast differentiation (GO:0045672)3.56957367
59activation of adenylate cyclase activity (GO:0007190)3.51515563
60neuromuscular synaptic transmission (GO:0007274)3.49538447
61genetic imprinting (GO:0071514)3.47687497
62protein maturation by protein folding (GO:0022417)3.43564695
63regulation of cAMP-mediated signaling (GO:0043949)3.41211922
64sarcoplasmic reticulum calcium ion transport (GO:0070296)3.38956034
65regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.38818314
66negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.38199691
67tongue development (GO:0043586)3.30583680
68cellular response to fatty acid (GO:0071398)3.28336828
69positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.25630976
70cell communication by electrical coupling (GO:0010644)3.15510687
71phenol-containing compound catabolic process (GO:0019336)3.14621950
72negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.13381850
73cyclic purine nucleotide metabolic process (GO:0052652)3.10966264
74positive regulation of adenylate cyclase activity (GO:0045762)3.08824122
75cAMP metabolic process (GO:0046058)3.07706637
76tyrosine metabolic process (GO:0006570)3.05027755
77peripheral nervous system neuron development (GO:0048935)3.03984000
78response to glucagon (GO:0033762)3.01762242
79catecholamine transport (GO:0051937)3.01719704
80catecholamine metabolic process (GO:0006584)3.01079314
81catechol-containing compound metabolic process (GO:0009712)3.01079314
82cellular response to ketone (GO:1901655)3.00438858
83dopamine metabolic process (GO:0042417)2.96879423
84cyclic nucleotide biosynthetic process (GO:0009190)2.93496193
85toxin metabolic process (GO:0009404)2.93200493
86SMAD protein complex assembly (GO:0007183)2.92731280
87cellular zinc ion homeostasis (GO:0006882)2.90579398
88polyamine biosynthetic process (GO:0006596)2.82654034
89replacement ossification (GO:0036075)2.81741197
90endochondral ossification (GO:0001958)2.81741197
91cell differentiation in hindbrain (GO:0021533)2.80473590
92regulation of neurotransmitter secretion (GO:0046928)2.78827374
93apoptotic process involved in morphogenesis (GO:0060561)2.78413315
94positive regulation of transcription regulatory region DNA binding (GO:2000679)2.75186738
95regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.74027781
96regulation of synaptic vesicle exocytosis (GO:2000300)2.72978392
97bone development (GO:0060348)2.72307968
98water transport (GO:0006833)2.70591691
99sympathetic nervous system development (GO:0048485)11.0430120
100response to parathyroid hormone (GO:0071107)10.6891786

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.57723988
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.53468426
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.30804824
4SUZ12_18692474_ChIP-Seq_MEFs_Mouse3.22926704
5ZNF263_19887448_ChIP-Seq_K562_Human3.12893878
6EZH2_18974828_ChIP-Seq_MESCs_Mouse3.09850882
7RNF2_18974828_ChIP-Seq_MESCs_Mouse3.09850882
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.96435376
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.89252688
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86544033
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.83669366
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.80810812
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.80204297
14ERG_21242973_ChIP-ChIP_JURKAT_Human2.59337762
15NR3C1_23031785_ChIP-Seq_PC12_Mouse2.56508978
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.53850288
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45121954
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.43418706
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.41063974
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.34143943
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.30985916
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.30449931
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.28934256
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.26190910
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.23700350
26EZH2_22144423_ChIP-Seq_EOC_Human2.21639530
27VDR_22108803_ChIP-Seq_LS180_Human2.12849785
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09550873
29TRIM28_21343339_ChIP-Seq_HEK293_Human2.03610221
30KDM2B_26808549_Chip-Seq_K562_Human1.94895165
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.94727505
32ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.92844279
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.85834495
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80648642
35LXR_22292898_ChIP-Seq_THP-1_Human1.72095156
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.64950927
37BCAT_22108803_ChIP-Seq_LS180_Human1.62328706
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58970143
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.58724012
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58259072
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.56286916
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54527525
43GATA1_19941826_ChIP-Seq_K562_Human1.53680143
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44928177
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41664820
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41635155
47* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.41600600
48RING1B_27294783_Chip-Seq_NPCs_Mouse1.35309022
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33456696
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.32639287
51RUNX_20019798_ChIP-Seq_JUKART_Human1.27872446
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26018394
53CLOCK_20551151_ChIP-Seq_293T_Human1.25638157
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24948925
55RXR_22158963_ChIP-Seq_LIVER_Mouse1.20888429
56HTT_18923047_ChIP-ChIP_STHdh_Human1.20731560
57TP53_20018659_ChIP-ChIP_R1E_Mouse1.20054146
58OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19174091
59PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16571631
60CTCF_20526341_ChIP-Seq_ESCs_Human1.15221410
61EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09723770
62HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09314719
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09228081
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08468314
65STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.06793687
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.03914837
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.01866948
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01281272
69REST_21632747_ChIP-Seq_MESCs_Mouse1.00372370
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.00361952
71KDM2B_26808549_Chip-Seq_DND41_Human0.99158513
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97624255
73STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95495812
74* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92919158
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92583162
76KDM2B_26808549_Chip-Seq_JURKAT_Human0.91955774
77SOX2_20726797_ChIP-Seq_SW620_Human0.91426108
78TP53_18474530_ChIP-ChIP_U2OS_Human0.87831832
79TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87688567
80YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87189375
81TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87113579
82ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86673140
83IKZF1_21737484_ChIP-ChIP_HCT116_Human0.86548278
84SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86311644
85PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.86178189
86EP300_21415370_ChIP-Seq_HL-1_Mouse0.85916933
87TET1_21490601_ChIP-Seq_MESCs_Mouse0.85278003
88* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.84266496
89P300_19829295_ChIP-Seq_ESCs_Human0.83889894
90SOX2_21211035_ChIP-Seq_LN229_Gbm0.83472837
91MYC_19915707_ChIP-ChIP_AK7_Human0.83208379
92TET1_21451524_ChIP-Seq_MESCs_Mouse0.82860685
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81603326
94PIAS1_25552417_ChIP-Seq_VCAP_Human0.80635738
95GBX2_23144817_ChIP-Seq_PC3_Human0.78663795
96ESR2_21235772_ChIP-Seq_MCF-7_Human0.77608446
97RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77128202
98LXR_22158963_ChIP-Seq_LIVER_Mouse0.76434345
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76412835
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.75960537

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex7.69736996
2MP0003787_abnormal_imprinting7.00465781
3MP0003123_paternal_imprinting6.83077855
4MP0005645_abnormal_hypothalamus_physiol5.25619663
5MP0003122_maternal_imprinting5.21523122
6MP0010386_abnormal_urinary_bladder4.85782262
7MP0008877_abnormal_DNA_methylation4.46635605
8MP0004130_abnormal_muscle_cell2.71051164
9MP0002822_catalepsy2.64576649
10MP0000003_abnormal_adipose_tissue2.38907943
11MP0003121_genomic_imprinting2.13454545
12MP0002751_abnormal_autonomic_nervous2.09465694
13MP0004043_abnormal_pH_regulation2.01808415
14MP0002909_abnormal_adrenal_gland1.98977875
15MP0009046_muscle_twitch1.78566768
16MP0005647_abnormal_sex_gland1.68015208
17MP0000538_abnormal_urinary_bladder1.66936758
18MP0003959_abnormal_lean_body1.66713883
19MP0001727_abnormal_embryo_implantation1.57402689
20MP0001270_distended_abdomen1.52377966
21MP0009745_abnormal_behavioral_response1.46711824
22MP0005085_abnormal_gallbladder_physiolo1.45264123
23MP0003195_calcinosis1.41244426
24MP0005623_abnormal_meninges_morphology1.41169644
25MP0005167_abnormal_blood-brain_barrier1.32249951
26MP0000230_abnormal_systemic_arterial1.31576141
27MP0001765_abnormal_ion_homeostasis1.27244516
28MP0002127_abnormal_cardiovascular_syste1.25826856
29MP0003638_abnormal_response/metabolism_1.24179065
30MP0003635_abnormal_synaptic_transmissio1.22596172
31MP0000751_myopathy1.20137166
32MP0004859_abnormal_synaptic_plasticity1.15500925
33MP0005375_adipose_tissue_phenotype1.13631919
34MP0005197_abnormal_uvea_morphology1.10726482
35MP0005584_abnormal_enzyme/coenzyme_acti1.07534618
36MP0003942_abnormal_urinary_system1.07103623
37MP0002009_preneoplasia1.01455832
38MP0004270_analgesia0.98394213
39MP0001905_abnormal_dopamine_level0.97819099
40MP0005360_urolithiasis0.96333012
41MP0001756_abnormal_urination0.95923723
42MP0009840_abnormal_foam_cell0.92846323
43MP0006138_congestive_heart_failure0.92776656
44MP0009672_abnormal_birth_weight0.91785573
45MP0002064_seizures0.89959555
46MP0001968_abnormal_touch/_nociception0.89283829
47MP0004858_abnormal_nervous_system0.86853876
48MP0005319_abnormal_enzyme/_coenzyme0.85697749
49MP0009703_decreased_birth_body0.84654102
50MP0002971_abnormal_brown_adipose0.83182693
51MP0006276_abnormal_autonomic_nervous0.83006504
52MP0002063_abnormal_learning/memory/cond0.80944652
53MP0002139_abnormal_hepatobiliary_system0.80285404
54MP0005636_abnormal_mineral_homeostasis0.77921578
55MP0002272_abnormal_nervous_system0.77100911
56MP0002572_abnormal_emotion/affect_behav0.76633816
57MP0004085_abnormal_heartbeat0.75786808
58MP0000749_muscle_degeneration0.72163252
59MP0003631_nervous_system_phenotype0.72036739
60MP0002733_abnormal_thermal_nociception0.70588511
61MP0003633_abnormal_nervous_system0.68904558
62MP0003948_abnormal_gas_homeostasis0.68569023
63MP0003632_abnormal_nervous_system0.67614861
64MP0003252_abnormal_bile_duct0.65905948
65MP0003567_abnormal_fetal_cardiomyocyte0.65762283
66MP0003953_abnormal_hormone_level0.65664406
67MP0002067_abnormal_sensory_capabilities0.65381076
68MP0009643_abnormal_urine_homeostasis0.64911773
69MP0002163_abnormal_gland_morphology0.61837577
70MP0001943_abnormal_respiration0.61800049
71MP0001177_atelectasis0.60784610
72MP0000762_abnormal_tongue_morphology0.60545002
73MP0000631_abnormal_neuroendocrine_gland0.59326720
74MP0000249_abnormal_blood_vessel0.56246214
75MP0001970_abnormal_pain_threshold0.56051070
76MP0008872_abnormal_physiological_respon0.55109296
77MP0005083_abnormal_biliary_tract0.54241859
78MP0002060_abnormal_skin_morphology0.54162453
79MP0004885_abnormal_endolymph0.53367447
80MP0002069_abnormal_eating/drinking_beha0.52412876
81MP0003279_aneurysm0.52365616
82MP0005365_abnormal_bile_salt0.51059711
83MP0002138_abnormal_hepatobiliary_system0.50867919
84MP0002066_abnormal_motor_capabilities/c0.49128596
85MP0000955_abnormal_spinal_cord0.48792024
86MP0002078_abnormal_glucose_homeostasis0.47816537
87MP0010329_abnormal_lipoprotein_level0.47793182
88MP0004134_abnormal_chest_morphology0.47228986
89MP0010770_preweaning_lethality0.46097121
90MP0002082_postnatal_lethality0.46097121
91MP0002152_abnormal_brain_morphology0.45906490
92MP0001440_abnormal_grooming_behavior0.45609772
93MP0004811_abnormal_neuron_physiology0.45211854
94MP0009115_abnormal_fat_cell0.44508026
95MP0008874_decreased_physiological_sensi0.44142289
96MP0005464_abnormal_platelet_physiology0.43490857
97MP0001529_abnormal_vocalization0.42179369
98MP0005334_abnormal_fat_pad0.41908554
99MP0002734_abnormal_mechanical_nocicepti0.41523260
100MP0008770_decreased_survivor_rate0.40958858

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)9.02451621
2Enlarged penis (HP:0000040)8.60404803
3Menstrual irregularities (HP:0000858)8.12258608
4Agitation (HP:0000713)7.07917070
5Hyperthyroidism (HP:0000836)6.75757974
6Macroorchidism (HP:0000053)6.42104627
7Steatorrhea (HP:0002570)6.21503690
8Growth hormone excess (HP:0000845)6.07157577
9Rhinitis (HP:0012384)6.06095144
10Hypercortisolism (HP:0001578)5.44252616
11Hyperphosphatemia (HP:0002905)5.23248681
12Fat malabsorption (HP:0002630)5.08766101
13Testicular neoplasm (HP:0010788)5.03725779
14Restlessness (HP:0000711)4.96096308
15Hyperparathyroidism (HP:0000843)4.80986448
16Cranial hyperostosis (HP:0004437)4.79653407
17Abnormality of calcium-phosphate metabolism (HP:0100530)4.74771052
18Striae distensae (HP:0001065)4.71757616
19Abnormality of aromatic amino acid family metabolism (HP:0004338)4.18228335
20Hypothermia (HP:0002045)4.11190810
21Exotropia (HP:0000577)4.00550489
22Amblyopia (HP:0000646)3.82702833
23Hypoventilation (HP:0002791)3.79711352
24Thickened calvaria (HP:0002684)3.62525452
25Basal ganglia calcification (HP:0002135)3.60972636
26Adrenal overactivity (HP:0002717)3.40504897
27Pathologic fracture (HP:0002756)3.29598680
28Decreased circulating renin level (HP:0003351)3.21841261
29Polycythemia (HP:0001901)2.95609771
30Goiter (HP:0000853)2.94482737
31Limb dystonia (HP:0002451)2.89792004
32Hyperactive renin-angiotensin system (HP:0000841)2.85035281
33Anxiety (HP:0000739)2.72381807
34Hypophosphatemia (HP:0002148)2.67410718
35Depression (HP:0000716)2.65929356
36Truncal obesity (HP:0001956)2.61254048
37Osteopenia (HP:0000938)2.60736397
38Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.50000519
39Myokymia (HP:0002411)2.49530080
40External ophthalmoplegia (HP:0000544)2.48542439
41Hyperpituitarism (HP:0010514)2.43631470
42Short metatarsal (HP:0010743)2.43467856
43Hypokalemic alkalosis (HP:0001949)2.43350150
44Craniofacial hyperostosis (HP:0004493)2.40362281
45Intestinal polyposis (HP:0200008)2.39796433
46Limb hypertonia (HP:0002509)2.36768806
47Lack of skin elasticity (HP:0100679)2.30628232
48Generalized hyperpigmentation (HP:0007440)2.29808915
49Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.23482453
50Neuroblastoma (HP:0003006)2.23482453
51Primitive neuroectodermal tumor (HP:0030065)2.23482453
52Neuroblastic tumors (HP:0004376)2.23482453
53Psychosis (HP:0000709)2.21412701
54Intestinal polyp (HP:0005266)2.17362800
55Aplasia/Hypoplasia of metatarsal bones (HP:0001964)2.15018507
56Alkalosis (HP:0001948)2.14470140
57Hypotension (HP:0002615)2.08088366
58Poor suck (HP:0002033)2.05112560
59Orthostatic hypotension (HP:0001278)2.04492200
60Malnutrition (HP:0004395)10.6536012
61Bone pain (HP:0002653)1.98107111
62Precocious puberty (HP:0000826)1.95935584
63Hypocalcemia (HP:0002901)1.86796958
64Hypoplasia of dental enamel (HP:0006297)1.86734581
65Neoplasm of the thyroid gland (HP:0100031)1.82655393
66Hypokinesia (HP:0002375)1.81330657
67Spastic diplegia (HP:0001264)1.79735924
68Neonatal hypoglycemia (HP:0001998)1.78181481
69Conjugated hyperbilirubinemia (HP:0002908)1.76440991
70Left ventricular hypertrophy (HP:0001712)1.76229115
71Exercise-induced myalgia (HP:0003738)1.75268495
72Abnormality of the basal ganglia (HP:0002134)1.74959418
73Global brain atrophy (HP:0002283)1.72047731
74Abnormality of renin-angiotensin system (HP:0000847)1.71331473
75Methylmalonic acidemia (HP:0002912)1.70890430
76Generalized tonic-clonic seizures (HP:0002069)1.67902017
77Osteoarthritis (HP:0002758)1.67552630
78Episodic fever (HP:0001954)1.66116471
79Renal salt wasting (HP:0000127)1.61259694
80Abnormality of homocysteine metabolism (HP:0010919)1.60829277
81Homocystinuria (HP:0002156)1.60829277
82Supranuclear gaze palsy (HP:0000605)1.55844398
83Skin rash (HP:0000988)1.55452495
84Retinal dysplasia (HP:0007973)1.54965667
85Asthma (HP:0002099)1.53335560
86Abnormality of chloride homeostasis (HP:0011422)1.51804366
87Hyperventilation (HP:0002883)1.50256458
88Abnormal autonomic nervous system physiology (HP:0012332)1.46847711
89Abnormal pupillary function (HP:0007686)1.46152912
90Abnormality of monocarboxylic acid metabolism (HP:0010996)1.40938778
91Abnormal gallbladder physiology (HP:0012438)1.39187196
92Cholecystitis (HP:0001082)1.39187196
93Fragile skin (HP:0001030)1.38971557
94Round face (HP:0000311)1.38782200
95Hyperkalemia (HP:0002153)1.38369032
96Methylmalonic aciduria (HP:0012120)1.37942428
97Torticollis (HP:0000473)1.37108502
98Hyperaldosteronism (HP:0000859)1.36757178
99Metabolic alkalosis (HP:0200114)1.35992914
100Limb-girdle muscle atrophy (HP:0003797)1.32275978

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B4.46344652
2NTRK33.75839636
3BUB13.67929077
4CSNK1G33.22769340
5CSNK1G22.99598613
6DYRK32.76736828
7TGFBR12.75310285
8NTRK12.58222013
9CSNK1G12.56424977
10MAPKAPK52.44351254
11PDGFRA2.43689411
12CDK82.36426530
13TRIB32.07888980
14UHMK12.01719098
15SGK4941.98180344
16SGK2231.98180344
17NLK1.94104734
18EPHB21.80831761
19PHKG21.79700493
20PHKG11.79700493
21GRK71.75564165
22CSNK1A1L1.73511039
23DDR21.69740867
24PAK61.68701601
25LMTK21.66520414
26DAPK21.65204061
27TESK11.59651834
28GRK11.59566706
29IRAK21.42979936
30PAK31.31181362
31PDPK11.29148288
32PLK21.23601207
33PRKCG1.19057872
34RIPK41.13707204
35MINK11.13241746
36MATK1.10701391
37PRPF4B1.05325243
38EPHA41.00372380
39LIMK10.99182996
40ADRBK10.93001447
41MAP3K20.92635601
42GRK50.91852230
43CAMK2G0.89119756
44MAP2K10.86252517
45WNK40.83119372
46MAP3K40.77693173
47PDGFRB0.76868701
48FER0.76650967
49CDK150.76632359
50MAP3K30.76563717
51MET0.75571832
52CDK180.75553299
53KSR20.73172331
54TYRO30.71884650
55OXSR10.71195584
56GSK3A0.69859958
57HIPK20.68118008
58NTRK20.68069662
59CDK140.66093493
60CDK11A0.64668946
61PRKD10.64241104
62ILK0.62446071
63PRKCQ0.60023041
64PRKCZ0.58274217
65SGK30.57604525
66PTK2B0.56248187
67CDK50.54845585
68IRAK10.54279750
69DYRK20.51872674
70MAPK40.51718405
71PRKG20.51124827
72CAMK2B0.50574727
73LATS20.48748828
74ALK0.48561100
75ERN10.47909923
76FES0.47795654
77RPS6KA40.45599013
78AKT30.44102015
79CAMK2A0.44078816
80RPS6KA50.42573197
81CSNK1A10.40730458
82PRKCE0.38839709
83PRKACA0.38561926
84CAMK2D0.36343961
85ERBB30.34684705
86MARK10.33609891
87MST1R0.33574066
88CSNK1E0.33486016
89PAK10.32971821
90STK390.31836319
91PRKCB0.31357774
92PRKCD0.29910674
93EPHB10.29403666
94PTK60.27614727
95FLT30.27195648
96IGF1R0.26732532
97CAMK10.26715770
98SGK20.25990718
99FYN0.24810073
100MAP2K20.24476046

Predicted pathways (KEGG)

RankGene SetZ-score
1Cocaine addiction_Homo sapiens_hsa050303.21236177
2Vibrio cholerae infection_Homo sapiens_hsa051103.12795760
3Oxidative phosphorylation_Homo sapiens_hsa001903.01852943
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.87586043
5Parkinsons disease_Homo sapiens_hsa050122.71208474
6Glycerolipid metabolism_Homo sapiens_hsa005612.66252202
7Amphetamine addiction_Homo sapiens_hsa050312.60026205
8Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.46899044
9Synaptic vesicle cycle_Homo sapiens_hsa047212.25187078
10Renin secretion_Homo sapiens_hsa049242.24266431
11Bile secretion_Homo sapiens_hsa049762.16785710
12Alzheimers disease_Homo sapiens_hsa050102.04206136
13Cardiac muscle contraction_Homo sapiens_hsa042601.87669981
14Phospholipase D signaling pathway_Homo sapiens_hsa040721.86693688
15Collecting duct acid secretion_Homo sapiens_hsa049661.82242795
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80460481
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.77614260
18Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.75263521
19Long-term depression_Homo sapiens_hsa047301.73932593
20Dopaminergic synapse_Homo sapiens_hsa047281.73868167
21Ovarian steroidogenesis_Homo sapiens_hsa049131.71690741
22Circadian entrainment_Homo sapiens_hsa047131.69163786
23Serotonergic synapse_Homo sapiens_hsa047261.67434007
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.55099186
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52931093
26Choline metabolism in cancer_Homo sapiens_hsa052311.52672454
27Salivary secretion_Homo sapiens_hsa049701.46211720
28Insulin secretion_Homo sapiens_hsa049111.43239019
29Huntingtons disease_Homo sapiens_hsa050161.41144080
30Tyrosine metabolism_Homo sapiens_hsa003501.41022280
31Morphine addiction_Homo sapiens_hsa050321.40160033
32Cholinergic synapse_Homo sapiens_hsa047251.38696384
33Glycerophospholipid metabolism_Homo sapiens_hsa005641.36738974
34Sulfur relay system_Homo sapiens_hsa041221.35701276
35Thyroid hormone synthesis_Homo sapiens_hsa049181.33494796
36Gap junction_Homo sapiens_hsa045401.31992809
37Folate biosynthesis_Homo sapiens_hsa007901.29320914
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.26439207
39Gastric acid secretion_Homo sapiens_hsa049711.26322752
40Glutamatergic synapse_Homo sapiens_hsa047241.21616499
41GnRH signaling pathway_Homo sapiens_hsa049121.14218639
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13948489
43Phenylalanine metabolism_Homo sapiens_hsa003601.09769134
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07311453
45Estrogen signaling pathway_Homo sapiens_hsa049151.06845687
46Dilated cardiomyopathy_Homo sapiens_hsa054141.03670218
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00828760
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00041429
49Melanogenesis_Homo sapiens_hsa049160.97931527
50Alcoholism_Homo sapiens_hsa050340.94416070
51Arginine and proline metabolism_Homo sapiens_hsa003300.94190527
52Butanoate metabolism_Homo sapiens_hsa006500.93754786
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.93661978
54Nitrogen metabolism_Homo sapiens_hsa009100.91873052
55Tryptophan metabolism_Homo sapiens_hsa003800.84352662
56Amoebiasis_Homo sapiens_hsa051460.81780189
57Pancreatic secretion_Homo sapiens_hsa049720.81460215
58Histidine metabolism_Homo sapiens_hsa003400.81429385
59GABAergic synapse_Homo sapiens_hsa047270.78698017
60Oxytocin signaling pathway_Homo sapiens_hsa049210.71799533
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68897380
62Glucagon signaling pathway_Homo sapiens_hsa049220.65145017
63Platelet activation_Homo sapiens_hsa046110.59297341
64Taste transduction_Homo sapiens_hsa047420.58837605
65Sulfur metabolism_Homo sapiens_hsa009200.58009417
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57302306
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57227592
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56648820
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55632934
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55582409
71Phagosome_Homo sapiens_hsa041450.53917382
72cAMP signaling pathway_Homo sapiens_hsa040240.53188640
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50524897
74Calcium signaling pathway_Homo sapiens_hsa040200.48920768
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48809022
76Rheumatoid arthritis_Homo sapiens_hsa053230.46144763
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44902911
78Arginine biosynthesis_Homo sapiens_hsa002200.42957626
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40011325
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39787153
81Propanoate metabolism_Homo sapiens_hsa006400.38065303
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37792289
83Long-term potentiation_Homo sapiens_hsa047200.37392191
84Prion diseases_Homo sapiens_hsa050200.36420442
85Lysosome_Homo sapiens_hsa041420.35587968
86PPAR signaling pathway_Homo sapiens_hsa033200.34413573
87Thyroid cancer_Homo sapiens_hsa052160.30784802
88Olfactory transduction_Homo sapiens_hsa047400.29715069
89Peroxisome_Homo sapiens_hsa041460.27255302
90Metabolic pathways_Homo sapiens_hsa011000.24533727
91Nicotine addiction_Homo sapiens_hsa050330.23908662
92Renal cell carcinoma_Homo sapiens_hsa052110.23724261
93Steroid biosynthesis_Homo sapiens_hsa001000.23703967
94Biosynthesis of amino acids_Homo sapiens_hsa012300.22421006
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20666858
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.19694397
97Rap1 signaling pathway_Homo sapiens_hsa040150.18749379
98Fatty acid metabolism_Homo sapiens_hsa012120.18447945
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.17320651
100Dorso-ventral axis formation_Homo sapiens_hsa043200.17165120

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