HIGD2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of the cytochrome c oxidase complex (complex IV), which is the terminal enzyme in the mitochondrial respiratory chain. The encoded protein is an inner mitochondrial membrane protein and is a functional ortholog of the yeast respiratory supercomplex factor 1 (Rcf1). In mouse, the orthologous protein enhances cell survival under conditions of hypoxia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.45613085
2energy coupled proton transport, down electrochemical gradient (GO:0015985)8.00800981
3ATP synthesis coupled proton transport (GO:0015986)8.00800981
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.81401534
5respiratory electron transport chain (GO:0022904)7.16587223
6electron transport chain (GO:0022900)7.00294173
7ribosomal small subunit assembly (GO:0000028)6.49251631
8translational elongation (GO:0006414)5.58967429
9protein neddylation (GO:0045116)5.12438363
10viral life cycle (GO:0019058)4.99010493
11chaperone-mediated protein transport (GO:0072321)4.96088660
12protein complex biogenesis (GO:0070271)4.85665817
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.80888655
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.80888655
15NADH dehydrogenase complex assembly (GO:0010257)4.80888655
16cellular protein complex disassembly (GO:0043624)4.78082963
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.66043573
18oxidative phosphorylation (GO:0006119)4.64271688
19ATP biosynthetic process (GO:0006754)4.60132043
20translational initiation (GO:0006413)4.58968088
21hydrogen ion transmembrane transport (GO:1902600)4.49996092
22translation (GO:0006412)4.40941972
23mitochondrial respiratory chain complex assembly (GO:0033108)4.38635731
24fatty acid elongation (GO:0030497)4.33577384
25ribosomal large subunit biogenesis (GO:0042273)4.28209229
26purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.23635841
27central nervous system myelination (GO:0022010)4.21916423
28axon ensheathment in central nervous system (GO:0032291)4.21916423
29purine nucleoside triphosphate biosynthetic process (GO:0009145)4.18428419
30proton transport (GO:0015992)4.05687359
31maturation of SSU-rRNA (GO:0030490)4.04264865
32hydrogen transport (GO:0006818)3.99925696
33protein targeting to membrane (GO:0006612)3.94701455
34pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.92241310
35protein complex disassembly (GO:0043241)3.91007429
36inner mitochondrial membrane organization (GO:0007007)3.79713215
37macromolecular complex disassembly (GO:0032984)3.72165182
38negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.65001689
39ribonucleoside triphosphate biosynthetic process (GO:0009201)3.64864672
40respiratory chain complex IV assembly (GO:0008535)3.59674889
41establishment of protein localization to mitochondrial membrane (GO:0090151)3.51478935
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.51008508
43positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.39478677
44cellular component biogenesis (GO:0044085)3.36318824
45nuclear-transcribed mRNA catabolic process (GO:0000956)3.32457294
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.31903495
47negative regulation of ligase activity (GO:0051352)3.31903495
48DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.31117552
49DNA deamination (GO:0045006)3.25817305
50rRNA modification (GO:0000154)3.25273379
51deoxyribonucleotide catabolic process (GO:0009264)3.24901001
52regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.21953974
53iron-sulfur cluster assembly (GO:0016226)3.20343208
54metallo-sulfur cluster assembly (GO:0031163)3.20343208
55RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.19993118
56tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.19993118
57deoxyribose phosphate catabolic process (GO:0046386)3.18402934
58intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.17049187
59signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.17049187
60regulation of oxidative phosphorylation (GO:0002082)3.16858433
61signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.16090233
62signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.16090233
63signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.16090233
64mRNA catabolic process (GO:0006402)3.14180680
65base-excision repair, AP site formation (GO:0006285)3.12614076
66purine nucleotide salvage (GO:0032261)3.10405830
67cytochrome complex assembly (GO:0017004)3.10366430
68energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.09364187
69ATP hydrolysis coupled proton transport (GO:0015991)3.09364187
70nucleoside triphosphate biosynthetic process (GO:0009142)3.09349166
71ribosomal small subunit biogenesis (GO:0042274)3.06729895
72pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.06632069
73pyrimidine nucleotide catabolic process (GO:0006244)3.06533303
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.06033144
75substantia nigra development (GO:0021762)3.05142886
76peptidyl-histidine modification (GO:0018202)3.04147525
77formation of translation preinitiation complex (GO:0001731)3.04093961
78mitochondrial transport (GO:0006839)3.03811336
79anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.02798235
80aerobic respiration (GO:0009060)3.02768472
81signal transduction involved in DNA damage checkpoint (GO:0072422)3.02151262
82signal transduction involved in DNA integrity checkpoint (GO:0072401)3.02151262
83cullin deneddylation (GO:0010388)3.01284276
84pseudouridine synthesis (GO:0001522)3.00244597
85ribonucleoprotein complex biogenesis (GO:0022613)2.98870814
86aldehyde catabolic process (GO:0046185)2.98730120
87guanosine-containing compound biosynthetic process (GO:1901070)2.97500683
88protein targeting to mitochondrion (GO:0006626)2.97093772
89signal transduction involved in cell cycle checkpoint (GO:0072395)2.96204960
90GTP biosynthetic process (GO:0006183)2.95899133
91antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.94063682
92cellular response to oxygen radical (GO:0071450)2.93440096
93removal of superoxide radicals (GO:0019430)2.93440096
94cellular response to superoxide (GO:0071451)2.93440096
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93002851
96establishment of protein localization to mitochondrion (GO:0072655)2.85861212
97regulation of mitochondrial translation (GO:0070129)2.83352947
98regulation of autophagic vacuole assembly (GO:2000785)2.82974559
99dopamine transport (GO:0015872)2.80657222
100proteasome assembly (GO:0043248)2.80576108
101intracellular protein transmembrane import (GO:0044743)2.79676905
102L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.77429876
103glutathione biosynthetic process (GO:0006750)2.76463255
104regulation of cellular respiration (GO:0043457)2.74516243
105generation of precursor metabolites and energy (GO:0006091)2.67719337
106protein localization to mitochondrion (GO:0070585)2.66438788
107sequestering of actin monomers (GO:0042989)2.65500120
108negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.65164083
109erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.64779466
110L-phenylalanine catabolic process (GO:0006559)2.64779466
111nonribosomal peptide biosynthetic process (GO:0019184)2.63856082
112cellular ketone body metabolic process (GO:0046950)2.62784925
113cholesterol biosynthetic process (GO:0006695)2.62475949
114viral transcription (GO:0019083)2.57303756
115dopamine biosynthetic process (GO:0042416)2.56362252
116purine nucleoside monophosphate biosynthetic process (GO:0009127)2.56236955
117purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.56236955
118tricarboxylic acid cycle (GO:0006099)2.54573742
119purine ribonucleoside biosynthetic process (GO:0046129)2.54294502
120purine nucleoside biosynthetic process (GO:0042451)2.54294502
121cotranslational protein targeting to membrane (GO:0006613)2.54054840
122protein targeting to ER (GO:0045047)2.53132328
123L-phenylalanine metabolic process (GO:0006558)2.52557222
124erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.52557222
125NADH metabolic process (GO:0006734)2.51898633
126GPI anchor biosynthetic process (GO:0006506)2.50156663
127negative regulation of protein localization to cell surface (GO:2000009)2.48866245
128protein localization to endoplasmic reticulum (GO:0070972)2.48773102
129cellular response to leptin stimulus (GO:0044320)2.47873999
130long-chain fatty acid biosynthetic process (GO:0042759)2.46038374
131regulation of vacuole organization (GO:0044088)2.45290286
132ubiquinone biosynthetic process (GO:0006744)2.44411121
133quinone biosynthetic process (GO:1901663)2.44411121
134glutathione metabolic process (GO:0006749)2.43069637
135regulation of dopamine metabolic process (GO:0042053)2.42987334
136regulation of catecholamine metabolic process (GO:0042069)2.42987334
137SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.42346919
138translational termination (GO:0006415)2.41877041
139mannosylation (GO:0097502)2.41019178
140establishment of protein localization to endoplasmic reticulum (GO:0072599)2.40983536
141regulation of cellular amino acid metabolic process (GO:0006521)2.39913391
142amyloid precursor protein metabolic process (GO:0042982)2.39717234
143cellular response to cadmium ion (GO:0071276)2.39397073
144positive regulation of cellular amine metabolic process (GO:0033240)2.36887001
145glutathione derivative metabolic process (GO:1901685)2.36871818
146glutathione derivative biosynthetic process (GO:1901687)2.36871818
147termination of RNA polymerase III transcription (GO:0006386)2.36379656
148transcription elongation from RNA polymerase III promoter (GO:0006385)2.36379656
149sterol biosynthetic process (GO:0016126)2.35142104
150L-methionine salvage (GO:0071267)2.34729260
151L-methionine biosynthetic process (GO:0071265)2.34729260
152amino acid salvage (GO:0043102)2.34729260
153ubiquinone metabolic process (GO:0006743)2.34439445

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.04251310
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.12584124
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.86057967
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.78841911
5EZH2_22144423_ChIP-Seq_EOC_Human2.69827233
6ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.64406223
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62030611
8PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.52352977
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.49250826
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.48652673
11* VDR_23849224_ChIP-Seq_CD4+_Human2.47541333
12VDR_22108803_ChIP-Seq_LS180_Human2.33112116
13FOXP3_21729870_ChIP-Seq_TREG_Human2.32699974
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.31840546
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.31627647
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.15115996
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14351371
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14070498
19* SRF_21415370_ChIP-Seq_HL-1_Mouse2.05338509
20CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.05249116
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04779566
22* XRN2_22483619_ChIP-Seq_HELA_Human2.04464199
23* EST1_17652178_ChIP-ChIP_JURKAT_Human2.04313754
24* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.99935538
25MYC_19079543_ChIP-ChIP_MESCs_Mouse1.98181719
26DCP1A_22483619_ChIP-Seq_HELA_Human1.90394965
27GABP_19822575_ChIP-Seq_HepG2_Human1.87859528
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84544680
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.81459057
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.81055851
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.80394287
32* ETS1_20019798_ChIP-Seq_JURKAT_Human1.78041474
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.76688369
34TTF2_22483619_ChIP-Seq_HELA_Human1.75273834
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73789938
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73105982
37ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.67704461
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66998179
39* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65366360
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64662008
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.64396264
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63636393
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62838852
44ELK1_19687146_ChIP-ChIP_HELA_Human1.62205197
45GBX2_23144817_ChIP-Seq_PC3_Human1.60156129
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.59936296
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.55877323
48BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.50972539
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.48643253
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44061642
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42944056
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42144704
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41725066
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40263282
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.39396930
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38384730
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36768991
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36737385
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36008495
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.35512387
61MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34119238
62TAF15_26573619_Chip-Seq_HEK293_Human1.34114508
63IRF8_22096565_ChIP-ChIP_GC-B_Human1.33707423
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33125804
65CTCF_18555785_ChIP-Seq_MESCs_Mouse1.30251012
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29616991
67RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29616991
68* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28261531
69EZH2_27294783_Chip-Seq_ESCs_Mouse1.24313130
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.23746732
71* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23343033
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22296175
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21449767
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21430810
75BCL6_27268052_Chip-Seq_Bcells_Human1.20386996
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17506682
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16785845
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16633814
79RAD21_21589869_ChIP-Seq_MESCs_Mouse1.16457951
80CTCF_26484167_Chip-Seq_Bcells_Mouse1.16243321
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15408316
82ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13210249
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13162340
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13151075
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12888108
86* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12696926
87IRF1_19129219_ChIP-ChIP_H3396_Human1.12271005
88MYC_18940864_ChIP-ChIP_HL60_Human1.12177624
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12098930
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12088005
91ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11566397
92ELF1_20517297_ChIP-Seq_JURKAT_Human1.11436498
93NANOG_20526341_ChIP-Seq_ESCs_Human1.10795256
94ELK1_22589737_ChIP-Seq_MCF10A_Human1.10743691
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.09898669
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08925854
97HTT_18923047_ChIP-ChIP_STHdh_Human1.08799877
98* TET1_21451524_ChIP-Seq_MESCs_Mouse1.08745761
99CIITA_25753668_ChIP-Seq_RAJI_Human1.08555755
100* SPI1_23547873_ChIP-Seq_NB4_Human1.07807500
101FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07777328
102PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06332940
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05852585
104CBX2_27304074_Chip-Seq_ESCs_Mouse1.05456551
105FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.04729946
106SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04413527
107CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04356128
108SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02375074
109NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02246981
110FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.01685270
111* REST_18959480_ChIP-ChIP_MESCs_Mouse1.01414754
112REST_21632747_ChIP-Seq_MESCs_Mouse1.01157460
113STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99404355
114RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98555812
115FOXP1_21924763_ChIP-Seq_HESCs_Human0.97833192
116IRF8_21731497_ChIP-ChIP_J774_Mouse0.97377287
117STAT1_20625510_ChIP-Seq_HELA_Human0.97274206
118EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96842636
119RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96711871
120PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.96638794
121E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96490199
122KDM5A_27292631_Chip-Seq_BREAST_Human0.95569344
123* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95542553
124CTCF_20526341_ChIP-Seq_ESCs_Human0.94838648
125VDR_21846776_ChIP-Seq_THP-1_Human0.94388122
126TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93819051
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93774725
128SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93574231
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93510254
130EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93052073
131SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91764624
132* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91591392
133ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91467549
134ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91080609
135BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.90998953
136E2F4_17652178_ChIP-ChIP_JURKAT_Human0.90547283
137POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.90284814
138CTCF_27219007_Chip-Seq_Bcells_Human0.89626930
139E2F1_20622854_ChIP-Seq_HELA_Human0.89231267
140EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.88551204
141BCOR_27268052_Chip-Seq_Bcells_Human0.88170442
142SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86792912
143PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86314127
144NCOR_22424771_ChIP-Seq_293T_Human0.83495309
145PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83350240
146YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83061596
147CTBP2_25329375_ChIP-Seq_LNCAP_Human0.82459550
148EOMES_21245162_ChIP-Seq_HESCs_Human0.82455916
149ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82372623
150GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81564122
151SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80878168
152YY1_22570637_ChIP-Seq_MALME-3M_Human0.80753172
153IKZF1_21737484_ChIP-ChIP_HCT116_Human0.80351824
154* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.80048168
155* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.79917354
156MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.79415960
157TAF2_19829295_ChIP-Seq_ESCs_Human0.79005664
158SA1_27219007_Chip-Seq_Bcells_Human0.77993414
159TAL1_26923725_Chip-Seq_HPCs_Mouse0.77553528
160NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.76762606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.88859352
2MP0001529_abnormal_vocalization3.20598895
3MP0002837_dystrophic_cardiac_calcinosis3.03505865
4MP0001905_abnormal_dopamine_level2.81275392
5MP0005671_abnormal_response_to2.74896920
6MP0009379_abnormal_foot_pigmentation2.58314820
7MP0003806_abnormal_nucleotide_metabolis2.48922432
8MP0009333_abnormal_splenocyte_physiolog2.42116817
9MP0002163_abnormal_gland_morphology2.39344224
10MP0006276_abnormal_autonomic_nervous2.19494649
11MP0006036_abnormal_mitochondrial_physio2.17011708
12MP0004142_abnormal_muscle_tone2.12755257
13MP0002822_catalepsy2.10677946
14MP0009785_altered_susceptibility_to2.10113095
15MP0003186_abnormal_redox_activity2.03865360
16MP0002148_abnormal_hypersensitivity_rea2.01040604
17MP0001835_abnormal_antigen_presentation1.99672562
18MP0005360_urolithiasis1.96567348
19MP0003329_amyloid_beta_deposits1.94273086
20MP0000920_abnormal_myelination1.93634153
21MP0002736_abnormal_nociception_after1.89259064
22MP0002277_abnormal_respiratory_mucosa1.84985910
23MP0002272_abnormal_nervous_system1.84806614
24MP0004043_abnormal_pH_regulation1.84480093
25MP0003646_muscle_fatigue1.83573642
26MP0006082_CNS_inflammation1.81073384
27MP0000749_muscle_degeneration1.80056657
28MP0003195_calcinosis1.77754049
29MP0008875_abnormal_xenobiotic_pharmacok1.77664395
30MP0003123_paternal_imprinting1.76841950
31MP0004270_analgesia1.74487803
32MP0001968_abnormal_touch/_nociception1.71784869
33MP0002064_seizures1.69567788
34MP0005075_abnormal_melanosome_morpholog1.68477542
35MP0009745_abnormal_behavioral_response1.67745539
36MP0005084_abnormal_gallbladder_morpholo1.67505953
37MP0002139_abnormal_hepatobiliary_system1.62192360
38MP0004036_abnormal_muscle_relaxation1.56126592
39MP0000751_myopathy1.54756588
40MP0005670_abnormal_white_adipose1.53465656
41MP0004885_abnormal_endolymph1.52253688
42MP0001984_abnormal_olfaction1.52234387
43MP0005025_abnormal_response_to1.50981508
44MP0005636_abnormal_mineral_homeostasis1.50922034
45MP0002735_abnormal_chemical_nociception1.48982774
46MP0009840_abnormal_foam_cell1.48682976
47MP0002733_abnormal_thermal_nociception1.48591829
48MP0005423_abnormal_somatic_nervous1.47767346
49MP0001970_abnormal_pain_threshold1.47588649
50MP0005332_abnormal_amino_acid1.47219530
51MP0005000_abnormal_immune_tolerance1.44753011
52MP0006035_abnormal_mitochondrial_morpho1.40130601
53MP0001873_stomach_inflammation1.39560002
54MP0001440_abnormal_grooming_behavior1.39345645
55MP0005085_abnormal_gallbladder_physiolo1.39083970
56MP0002734_abnormal_mechanical_nocicepti1.38872544
57MP0001800_abnormal_humoral_immune1.37302283
58MP0003011_delayed_dark_adaptation1.37229551
59MP0003786_premature_aging1.36987427
60MP0008058_abnormal_DNA_repair1.36834084
61MP0001486_abnormal_startle_reflex1.33923905
62MP0005058_abnormal_lysosome_morphology1.32684949
63MP0002638_abnormal_pupillary_reflex1.31352346
64MP0002572_abnormal_emotion/affect_behav1.30913768
65MP0001790_abnormal_immune_system1.30475501
66MP0005387_immune_system_phenotype1.30475501
67MP0003635_abnormal_synaptic_transmissio1.28499534
68MP0002723_abnormal_immune_serum1.28223128
69MP0005451_abnormal_body_composition1.25945293
70MP0004742_abnormal_vestibular_system1.25835046
71MP0009046_muscle_twitch1.25707692
72MP0002420_abnormal_adaptive_immunity1.23511312
73MP0000343_altered_response_to1.22647869
74MP0001853_heart_inflammation1.22453432
75MP0001819_abnormal_immune_cell1.22430178
76MP0004145_abnormal_muscle_electrophysio1.20182458
77MP0008995_early_reproductive_senescence1.19663908
78MP0002452_abnormal_antigen_presenting1.19653149
79MP0008469_abnormal_protein_level1.18917608
80MP0005584_abnormal_enzyme/coenzyme_acti1.17687556
81MP0004924_abnormal_behavior1.15529455
82MP0005386_behavior/neurological_phenoty1.15529455
83MP0001845_abnormal_inflammatory_respons1.14809232
84MP0003136_yellow_coat_color1.14411552
85MP0003693_abnormal_embryo_hatching1.13849263
86MP0003436_decreased_susceptibility_to1.13821419
87MP0008872_abnormal_physiological_respon1.13518554
88MP0003137_abnormal_impulse_conducting1.13354809
89MP0001485_abnormal_pinna_reflex1.13340243
90MP0005379_endocrine/exocrine_gland_phen1.12332451
91MP0004147_increased_porphyrin_level1.12065516
92MP0002229_neurodegeneration1.11110752
93MP0001501_abnormal_sleep_pattern1.10770945
94MP0005319_abnormal_enzyme/_coenzyme1.10462728
95MP0002132_abnormal_respiratory_system1.10440260
96MP0005551_abnormal_eye_electrophysiolog1.10040525
97MP0000685_abnormal_immune_system1.09649064
98MP0004957_abnormal_blastocyst_morpholog1.09347270
99MP0006072_abnormal_retinal_apoptosis1.09288972
100MP0005408_hypopigmentation1.06906602
101MP0005645_abnormal_hypothalamus_physiol1.06632270
102MP0002419_abnormal_innate_immunity1.06328541
103MP0005365_abnormal_bile_salt1.05193216
104MP0005646_abnormal_pituitary_gland1.05180109
105MP0004215_abnormal_myocardial_fiber1.04627821
106MP0002067_abnormal_sensory_capabilities1.03476653
107MP0001502_abnormal_circadian_rhythm1.03468948
108MP0005171_absent_coat_pigmentation1.02509410
109MP0010386_abnormal_urinary_bladder1.02154097
110MP0002063_abnormal_learning/memory/cond1.00361048
111MP0004019_abnormal_vitamin_homeostasis1.00281726
112MP0005330_cardiomyopathy1.00107070
113MP0005535_abnormal_body_temperature0.99219851
114MP0001963_abnormal_hearing_physiology0.99098726
115MP0002876_abnormal_thyroid_physiology0.99088186
116MP0005409_darkened_coat_color0.99014657
117MP0010155_abnormal_intestine_physiology0.98969646
118MP0009764_decreased_sensitivity_to0.98056288
119MP0001666_abnormal_nutrient_absorption0.98043242
120MP0002095_abnormal_skin_pigmentation0.96312055
121MP0002160_abnormal_reproductive_system0.94207548
122MP0003690_abnormal_glial_cell0.93161069
123MP0005389_reproductive_system_phenotype0.92559265
124MP0000716_abnormal_immune_system0.92474020
125MP0000230_abnormal_systemic_arterial0.92127545
126MP0001764_abnormal_homeostasis0.92072280
127MP0004381_abnormal_hair_follicle0.91494840
128MP0009643_abnormal_urine_homeostasis0.90664719
129MP0001727_abnormal_embryo_implantation0.90350671
130MP0003075_altered_response_to0.90239994
131MP0000372_irregular_coat_pigmentation0.89832219
132MP0001986_abnormal_taste_sensitivity0.89238889
133MP0001919_abnormal_reproductive_system0.88437923
134MP0005083_abnormal_biliary_tract0.88325447
135MP0001664_abnormal_digestion0.88023178
136MP0000750_abnormal_muscle_regeneration0.87125464
137MP0001765_abnormal_ion_homeostasis0.86856911
138MP0002066_abnormal_motor_capabilities/c0.85836452
139MP0002234_abnormal_pharynx_morphology0.85424699
140MP0005165_increased_susceptibility_to0.85264086
141MP0002972_abnormal_cardiac_muscle0.84611292
142MP0005620_abnormal_muscle_contractility0.84482778
143MP0005464_abnormal_platelet_physiology0.84333281
144MP0008789_abnormal_olfactory_epithelium0.83580142
145MP0000490_abnormal_crypts_of0.82577318
146MP0002332_abnormal_exercise_endurance0.82239773
147MP0003634_abnormal_glial_cell0.82234867
148MP0005166_decreased_susceptibility_to0.81908915
149MP0006292_abnormal_olfactory_placode0.81662149
150MP0000604_amyloidosis0.81297785
151MP0002429_abnormal_blood_cell0.79512120
152MP0005410_abnormal_fertilization0.79446769
153MP0003718_maternal_effect0.78847523
154MP0002398_abnormal_bone_marrow0.77978110
155MP0000026_abnormal_inner_ear0.77143203
156MP0000689_abnormal_spleen_morphology0.76919779
157MP0000566_synostosis0.76746730
158MP0001663_abnormal_digestive_system0.75790184
159MP0002653_abnormal_ependyma_morphology0.75122618
160MP0003866_abnormal_defecation0.73269429
161MP0003763_abnormal_thymus_physiology0.72257121
162MP0002722_abnormal_immune_system0.70974425

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.51648976
2Abnormal mitochondria in muscle tissue (HP:0008316)5.98450666
3Mitochondrial inheritance (HP:0001427)5.92811234
4Acute encephalopathy (HP:0006846)5.75393889
5Progressive macrocephaly (HP:0004481)5.29525030
6Hepatocellular necrosis (HP:0001404)5.27792373
7Increased CSF lactate (HP:0002490)5.08320675
8Hepatic necrosis (HP:0002605)4.83328552
9Increased hepatocellular lipid droplets (HP:0006565)4.66656140
10Lipid accumulation in hepatocytes (HP:0006561)4.45705164
11Renal Fanconi syndrome (HP:0001994)4.32697004
12Cerebral edema (HP:0002181)4.16216894
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.09473438
14Increased intramyocellular lipid droplets (HP:0012240)4.06604882
15Abnormality of glycolysis (HP:0004366)3.95316120
16Increased serum pyruvate (HP:0003542)3.95316120
17Respiratory failure (HP:0002878)3.77868479
18Increased muscle lipid content (HP:0009058)3.73687231
19Lactic acidosis (HP:0003128)3.61860135
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.61737470
213-Methylglutaconic aciduria (HP:0003535)3.58940325
22Leukodystrophy (HP:0002415)3.51556652
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.50547691
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.50547691
25Optic disc pallor (HP:0000543)3.48682331
26Exercise intolerance (HP:0003546)3.46807569
27Reticulocytopenia (HP:0001896)3.40827284
28Increased serum lactate (HP:0002151)3.20166878
29Neuroendocrine neoplasm (HP:0100634)3.16532619
30Pheochromocytoma (HP:0002666)3.11471556
31Exertional dyspnea (HP:0002875)3.07981823
32Abnormality of renal resorption (HP:0011038)3.04824843
33Myokymia (HP:0002411)3.00300933
34Abnormality of urine glucose concentration (HP:0011016)2.79686225
35Glycosuria (HP:0003076)2.79686225
36Respiratory difficulties (HP:0002880)2.77554696
37Hyperphosphaturia (HP:0003109)2.73997382
38Lethargy (HP:0001254)2.70545938
39Aplastic anemia (HP:0001915)2.64682828
40Elevated erythrocyte sedimentation rate (HP:0003565)2.51568202
41CNS demyelination (HP:0007305)2.45168598
42Parakeratosis (HP:0001036)2.42062112
43Pallor (HP:0000980)2.41955968
44Abnormality of aromatic amino acid family metabolism (HP:0004338)2.38909399
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.36670226
46Dicarboxylic aciduria (HP:0003215)2.36670226
47X-linked dominant inheritance (HP:0001423)2.35961985
48Abnormal urine phosphate concentration (HP:0012599)2.32925918
49Hypothermia (HP:0002045)2.31831360
50Neurofibrillary tangles (HP:0002185)2.29786106
51Testicular atrophy (HP:0000029)2.29102855
52Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.28824939
53Emotional lability (HP:0000712)2.28166783
54Methylmalonic aciduria (HP:0012120)2.27950363
55Type I transferrin isoform profile (HP:0003642)2.24512286
56Cerebral hemorrhage (HP:0001342)2.21285308
57Abnormality of fatty-acid metabolism (HP:0004359)2.20618292
58Sensory axonal neuropathy (HP:0003390)2.15535370
59Aplasia/Hypoplasia of the sacrum (HP:0008517)2.15487081
60Abnormal pupillary function (HP:0007686)2.13997168
61Cholecystitis (HP:0001082)2.10589006
62Abnormal gallbladder physiology (HP:0012438)2.10589006
63Abnormality of magnesium homeostasis (HP:0004921)2.08224654
64Nausea (HP:0002018)2.07958006
65Vomiting (HP:0002013)2.04376113
66Renal tubular dysfunction (HP:0000124)2.04077925
67Microvesicular hepatic steatosis (HP:0001414)2.03122915
68Congenital ichthyosiform erythroderma (HP:0007431)2.00916239
69Hyperventilation (HP:0002883)2.00804423
70Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.99451065
71Degeneration of the lateral corticospinal tracts (HP:0002314)1.99451065
72Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.98122885
73Hypomagnesemia (HP:0002917)1.96760016
74Pancytopenia (HP:0001876)1.95622909
75Abnormality of cells of the erythroid lineage (HP:0012130)1.95325048
76Nemaline bodies (HP:0003798)1.94304706
77Palpitations (HP:0001962)1.94251575
78Methylmalonic acidemia (HP:0002912)1.94191267
79Limb dystonia (HP:0002451)1.91856914
80Delayed CNS myelination (HP:0002188)1.88998922
81Muscle hypertrophy of the lower extremities (HP:0008968)1.88894898
82Muscle fiber inclusion bodies (HP:0100299)1.86665529
83Abnormal hemoglobin (HP:0011902)1.85619154
84Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85119827
85Exercise-induced myalgia (HP:0003738)1.83692858
86Cerebral palsy (HP:0100021)1.83622521
87Degeneration of anterior horn cells (HP:0002398)1.83069236
88Abnormality of the anterior horn cell (HP:0006802)1.83069236
89Increased circulating renin level (HP:0000848)1.82104723
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.81971408
91Abnormal protein N-linked glycosylation (HP:0012347)1.81971408
92Abnormal protein glycosylation (HP:0012346)1.81971408
93Abnormal glycosylation (HP:0012345)1.81971408
94Generalized aminoaciduria (HP:0002909)1.80704906
95Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.78072176
96Congenital, generalized hypertrichosis (HP:0004540)1.76709337
97Metabolic alkalosis (HP:0200114)1.76396350
98Abnormality of T cell physiology (HP:0011840)1.76020707
99Retinal dysplasia (HP:0007973)1.74605878
100Hypoplasia of the uterus (HP:0000013)1.73496478
101Amniotic constriction ring (HP:0009775)1.73087037
102Abnormality of placental membranes (HP:0011409)1.73087037
103Muscle fiber atrophy (HP:0100295)1.73059207
104Chronic obstructive pulmonary disease (HP:0006510)1.72480702
105Obstructive lung disease (HP:0006536)1.72480702
106Cerebral hypomyelination (HP:0006808)1.72033165
107Myopathic facies (HP:0002058)1.71835986
108Calf muscle hypertrophy (HP:0008981)1.71531002
109Abnormality of secondary sexual hair (HP:0009888)1.71390080
110Abnormality of the axillary hair (HP:0100134)1.71390080
111Aplasia/hypoplasia of the uterus (HP:0008684)1.70666738
112Ragged-red muscle fibers (HP:0003200)1.70254141
113Oral leukoplakia (HP:0002745)1.70016056
114Type 2 muscle fiber atrophy (HP:0003554)1.69912444
115Myotonia (HP:0002486)1.67063048
116Muscle fiber splitting (HP:0003555)1.66982063
117Rough bone trabeculation (HP:0100670)1.66439877
118Sudden death (HP:0001699)1.65255422
119Reduced antithrombin III activity (HP:0001976)1.64867282
120Macrocytic anemia (HP:0001972)1.64843381
121Petechiae (HP:0000967)1.64691995
122Paralysis (HP:0003470)1.64554051
123Abnormality of alanine metabolism (HP:0010916)1.64434037
124Hyperalaninemia (HP:0003348)1.64434037
125Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.64434037
126Abnormal number of erythroid precursors (HP:0012131)1.64325522
127Hypoplastic left heart (HP:0004383)1.63902818
128Microretrognathia (HP:0000308)1.63165737
129Muscle stiffness (HP:0003552)1.62945126
130Metabolic acidosis (HP:0001942)1.62779902
131Blindness (HP:0000618)1.62222201
132Hyperglycinemia (HP:0002154)1.61553142
133Cleft eyelid (HP:0000625)1.61402013
134Delusions (HP:0000746)1.60838043
135Vacuolated lymphocytes (HP:0001922)1.60658742
136Thrombocytosis (HP:0001894)1.59529456
137Stomatitis (HP:0010280)1.59020241
138Rhabdomyolysis (HP:0003201)1.58599049
139Cerebral inclusion bodies (HP:0100314)1.55836770
140Conjunctival hamartoma (HP:0100780)1.52652521
141Anxiety (HP:0000739)1.50560334
142Alkalosis (HP:0001948)1.50495131
143Spastic paraparesis (HP:0002313)1.49972666
144Myoglobinuria (HP:0002913)1.48875353
145Hypokalemic alkalosis (HP:0001949)1.48509103
146Abnormality of glycine metabolism (HP:0010895)1.48424500
147Abnormality of serine family amino acid metabolism (HP:0010894)1.48424500
148Hyperglycinuria (HP:0003108)1.47926754

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.61239286
2ARAF3.37760540
3STK393.35536682
4NME13.03346220
5OXSR12.85341787
6MAP3K122.67688853
7CASK2.66037581
8WNK42.64826057
9MYLK2.59821069
10STK162.48503713
11ZAK2.31276984
12MUSK2.25295474
13TLK12.22148128
14TAOK32.18349412
15NME22.14831434
16BCKDK2.10598946
17LIMK12.06532003
18GRK72.02500207
19MST42.01659446
20CDK191.87443575
21MAPKAPK51.87261520
22GRK51.86901561
23NEK11.82234673
24PIM21.65363372
25OBSCN1.65057314
26TESK21.58646829
27MAP4K21.58225417
28PHKG21.53822599
29PHKG11.53822599
30TNIK1.45459196
31ADRBK21.43232912
32PBK1.42844257
33MAP3K111.39681289
34DYRK21.39254017
35LRRK21.34161098
36MAP4K11.30795855
37CAMK2B1.30794889
38CAMK2D1.23089337
39NUAK11.22380401
40TXK1.21492393
41BRAF1.20541460
42TAF11.18134157
43TNK21.16668407
44CAMK2G1.10948065
45WNK31.08929628
46CAMK2A1.08464983
47ILK1.05698136
48BCR1.05121090
49CSNK1G31.04526430
50DAPK31.04446945
51PKN11.03688035
52TBK11.02770584
53TESK11.02112153
54BMPR20.97659908
55IKBKB0.95471226
56MAPK150.94000810
57VRK10.93480858
58MAP2K20.93277556
59UHMK10.93064328
60ADRBK10.91040098
61PNCK0.86696212
62ROCK20.86337511
63MAP2K70.84703273
64AURKA0.84336738
65EPHB20.83163862
66EIF2AK10.81592071
67ITK0.78945025
68KDR0.77569748
69ABL20.76780332
70MAPK130.75906787
71GRK60.74307494
72BMPR1B0.73907669
73PDK20.73228045
74TAOK20.73040665
75MAPKAPK30.72554829
76EPHA40.72059334
77PIK3CA0.71787348
78BUB10.69512607
79IRAK30.68847012
80LMTK20.68201905
81PTK2B0.67575509
82PRKCE0.65697801
83RPS6KA50.65255573
84DYRK30.63842473
85SRPK10.62569319
86TYK20.62494032
87PINK10.62239508
88NTRK10.61078663
89CSNK2A20.60682409
90SMG10.60617666
91PAK10.60278255
92BRSK10.60078902
93CSNK2A10.59486746
94PRKACA0.58718948
95BTK0.57715087
96PAK40.57365496
97FGR0.56957884
98CSNK1G20.56948401
99PLK20.56917130
100CDK140.56655079
101MARK10.56499446
102SIK30.56204581
103AURKB0.56001537
104FES0.55772387
105MOS0.54546594
106ZAP700.54270921
107CSNK1G10.53845268
108DAPK10.53267984
109CDK180.52914722
110CCNB10.52714588
111SGK2230.51897104
112SGK4940.51897104
113CDK150.51437791
114EIF2AK30.51386929
115CDK80.51038967
116PLK40.50975874
117LYN0.50866171
118MARK30.49407954
119PLK10.49372493
120PRKCG0.49149278
121TEC0.48933789
122CDK11A0.48818424
123CHEK20.48301057
124MAPK40.47929076
125TIE10.47737162
126CDK50.46810468
127SYK0.45557167
128INSRR0.45117794
129MAPK120.44652426
130CDC70.44345681
131DAPK20.43630534
132PASK0.43060766
133KSR20.42788993
134CAMK10.42737186
135PDK40.40747915
136PDK30.40747915
137PRKCQ0.40562406
138PLK30.40274844
139RAF10.39627814
140CSNK1A1L0.39358521
141NEK60.38732400
142PRPF4B0.37844147
143PRKG20.37346209
144PAK30.36449423
145PIM10.36180519
146TRIM280.35674942
147PIK3CG0.34598979
148GRK10.34459873
149MAP2K60.34233655
150CSF1R0.32417396
151CAMKK20.31740890
152PRKCD0.29551332
153RPS6KB20.29396607

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001906.09238084
2Parkinsons disease_Homo sapiens_hsa050125.08500504
3Alzheimers disease_Homo sapiens_hsa050103.88476826
4Huntingtons disease_Homo sapiens_hsa050163.37685271
5Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.26408735
6Cardiac muscle contraction_Homo sapiens_hsa042602.76180558
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.63796265
8Ribosome_Homo sapiens_hsa030102.58925172
9Fatty acid elongation_Homo sapiens_hsa000622.53208897
10Proteasome_Homo sapiens_hsa030502.34430327
11Collecting duct acid secretion_Homo sapiens_hsa049662.13360958
12Sulfur metabolism_Homo sapiens_hsa009202.11873433
13Protein export_Homo sapiens_hsa030602.04263615
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.03455423
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.84371160
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.64847885
17Pyruvate metabolism_Homo sapiens_hsa006201.62556535
18Propanoate metabolism_Homo sapiens_hsa006401.56785665
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51463282
20DNA replication_Homo sapiens_hsa030301.50065653
21Butanoate metabolism_Homo sapiens_hsa006501.48925024
22Mismatch repair_Homo sapiens_hsa034301.44532359
23Homologous recombination_Homo sapiens_hsa034401.44459504
24Asthma_Homo sapiens_hsa053101.43141217
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37111193
26Steroid biosynthesis_Homo sapiens_hsa001001.36677959
27RNA polymerase_Homo sapiens_hsa030201.36149337
28Base excision repair_Homo sapiens_hsa034101.35363613
29Graft-versus-host disease_Homo sapiens_hsa053321.34799681
30Primary immunodeficiency_Homo sapiens_hsa053401.30668211
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30494953
32Histidine metabolism_Homo sapiens_hsa003401.28294289
33Allograft rejection_Homo sapiens_hsa053301.25981159
34Vibrio cholerae infection_Homo sapiens_hsa051101.24733694
35Peroxisome_Homo sapiens_hsa041461.21757738
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21102926
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19500318
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19077340
39Autoimmune thyroid disease_Homo sapiens_hsa053201.15417084
40Tyrosine metabolism_Homo sapiens_hsa003501.12342928
41Glutathione metabolism_Homo sapiens_hsa004801.11641377
42Phenylalanine metabolism_Homo sapiens_hsa003601.08761167
43Spliceosome_Homo sapiens_hsa030401.05036175
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04772627
45Nucleotide excision repair_Homo sapiens_hsa034201.03301586
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02648855
47Synaptic vesicle cycle_Homo sapiens_hsa047211.01506488
48Carbon metabolism_Homo sapiens_hsa012001.01191897
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.99949237
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99705814
51Metabolic pathways_Homo sapiens_hsa011000.97593702
52Basal transcription factors_Homo sapiens_hsa030220.96358537
53Antigen processing and presentation_Homo sapiens_hsa046120.95430027
54Arginine and proline metabolism_Homo sapiens_hsa003300.95148558
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94191547
56Type I diabetes mellitus_Homo sapiens_hsa049400.91334986
57Ether lipid metabolism_Homo sapiens_hsa005650.90818401
58Chemical carcinogenesis_Homo sapiens_hsa052040.87298982
59Fatty acid metabolism_Homo sapiens_hsa012120.86689356
60Fatty acid degradation_Homo sapiens_hsa000710.86589161
61Linoleic acid metabolism_Homo sapiens_hsa005910.84127976
62RNA degradation_Homo sapiens_hsa030180.83615597
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78543131
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.73721182
65Folate biosynthesis_Homo sapiens_hsa007900.73526135
66Nicotine addiction_Homo sapiens_hsa050330.72674933
67Rheumatoid arthritis_Homo sapiens_hsa053230.72392651
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71538328
69Tryptophan metabolism_Homo sapiens_hsa003800.68994144
70Arachidonic acid metabolism_Homo sapiens_hsa005900.68584357
71Fanconi anemia pathway_Homo sapiens_hsa034600.67581586
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66785923
73beta-Alanine metabolism_Homo sapiens_hsa004100.63158659
74Serotonergic synapse_Homo sapiens_hsa047260.61535638
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.61339042
76GABAergic synapse_Homo sapiens_hsa047270.60306277
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60051005
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.59755403
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59473254
80One carbon pool by folate_Homo sapiens_hsa006700.58573587
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57669977
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55911337
83RNA transport_Homo sapiens_hsa030130.53895595
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50868398
85Pyrimidine metabolism_Homo sapiens_hsa002400.50309696
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50034978
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49123949
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.48453900
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48118944
90Phototransduction_Homo sapiens_hsa047440.47862081
91Systemic lupus erythematosus_Homo sapiens_hsa053220.47649613
92Fructose and mannose metabolism_Homo sapiens_hsa000510.47446721
93Caffeine metabolism_Homo sapiens_hsa002320.47366894
94Galactose metabolism_Homo sapiens_hsa000520.45398476
95Viral myocarditis_Homo sapiens_hsa054160.43464733
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42533575
97Biosynthesis of amino acids_Homo sapiens_hsa012300.42518960
98Staphylococcus aureus infection_Homo sapiens_hsa051500.42201956
99Mineral absorption_Homo sapiens_hsa049780.42189626
100Purine metabolism_Homo sapiens_hsa002300.41512201
101Epstein-Barr virus infection_Homo sapiens_hsa051690.38046854
102Hematopoietic cell lineage_Homo sapiens_hsa046400.37387156
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35789634
104Sulfur relay system_Homo sapiens_hsa041220.35280344
105Pentose phosphate pathway_Homo sapiens_hsa000300.35180875
106Phagosome_Homo sapiens_hsa041450.34866379
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33389069
108Taste transduction_Homo sapiens_hsa047420.33008931
109Fat digestion and absorption_Homo sapiens_hsa049750.32738397
110Sphingolipid metabolism_Homo sapiens_hsa006000.31849240
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31222922
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.30988939
113Regulation of autophagy_Homo sapiens_hsa041400.30726765
114Morphine addiction_Homo sapiens_hsa050320.30699334
115PPAR signaling pathway_Homo sapiens_hsa033200.29105661
116N-Glycan biosynthesis_Homo sapiens_hsa005100.28861953
117Retinol metabolism_Homo sapiens_hsa008300.27059346
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.26143913
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26110961
120Starch and sucrose metabolism_Homo sapiens_hsa005000.24202575
121Glutamatergic synapse_Homo sapiens_hsa047240.23933383
122Circadian entrainment_Homo sapiens_hsa047130.22006501
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.19424031
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19013417
125Cocaine addiction_Homo sapiens_hsa050300.18224748
126Vitamin digestion and absorption_Homo sapiens_hsa049770.17600854
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16211624
128Bile secretion_Homo sapiens_hsa049760.15866645
129Amphetamine addiction_Homo sapiens_hsa050310.15604390
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14881650
131Pancreatic secretion_Homo sapiens_hsa049720.14211344

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