HIKESHI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition of heat shock-induced nuclear accumulation of Hsp70s, indicating a role for this gene in regulation of Hsp70 nuclear import during heat shock stress. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.42452972
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.35129594
3ATP synthesis coupled proton transport (GO:0015986)6.35129594
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.65017988
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.45608571
6chaperone-mediated protein transport (GO:0072321)5.38842297
7respiratory electron transport chain (GO:0022904)5.30095839
8electron transport chain (GO:0022900)5.19532828
9proteasome assembly (GO:0043248)4.95663131
10protein complex biogenesis (GO:0070271)4.93944933
11protein neddylation (GO:0045116)4.85981809
12viral transcription (GO:0019083)4.82748213
13mitochondrial respiratory chain complex assembly (GO:0033108)4.79281800
14ribosomal small subunit assembly (GO:0000028)4.77266802
15translational termination (GO:0006415)4.77015747
16mitochondrial respiratory chain complex I assembly (GO:0032981)4.74013487
17NADH dehydrogenase complex assembly (GO:0010257)4.74013487
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.74013487
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.54868682
20cotranslational protein targeting to membrane (GO:0006613)4.53063691
21protein targeting to ER (GO:0045047)4.44890427
22establishment of protein localization to endoplasmic reticulum (GO:0072599)4.28434849
23protein localization to endoplasmic reticulum (GO:0070972)4.21973653
24termination of RNA polymerase III transcription (GO:0006386)4.21189808
25transcription elongation from RNA polymerase III promoter (GO:0006385)4.21189808
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.15166828
27ribosomal large subunit biogenesis (GO:0042273)4.06702656
28translational elongation (GO:0006414)4.04290025
29respiratory chain complex IV assembly (GO:0008535)4.03410587
30regulation of mitochondrial translation (GO:0070129)3.95174816
31nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.94151952
32ribosomal small subunit biogenesis (GO:0042274)3.88197518
33exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.87910123
34translation (GO:0006412)3.85681998
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.80527951
36positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.80405803
37maturation of SSU-rRNA (GO:0030490)3.78688947
38translational initiation (GO:0006413)3.76953088
39negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.75348320
40negative regulation of ligase activity (GO:0051352)3.75348320
41cullin deneddylation (GO:0010388)3.75178993
42chromatin remodeling at centromere (GO:0031055)3.71020075
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.70968837
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.70968837
45cytochrome complex assembly (GO:0017004)3.69438840
46cellular protein complex disassembly (GO:0043624)3.67131850
47CENP-A containing nucleosome assembly (GO:0034080)3.66547840
48establishment of integrated proviral latency (GO:0075713)3.65663250
49viral life cycle (GO:0019058)3.64991622
50anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.59030479
51regulation of cellular amino acid metabolic process (GO:0006521)3.56116078
52nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.55508375
53protein-cofactor linkage (GO:0018065)3.54702471
54DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.50378864
55protein targeting to mitochondrion (GO:0006626)3.49913361
56ATP biosynthetic process (GO:0006754)3.47193569
57signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.44753908
58signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.44753908
59signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.44753908
60hydrogen ion transmembrane transport (GO:1902600)3.43214510
61rRNA modification (GO:0000154)3.42662938
62signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.41257549
63intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.41257549
64protein deneddylation (GO:0000338)3.40418855
65sequestering of actin monomers (GO:0042989)3.37424344
66DNA damage response, detection of DNA damage (GO:0042769)3.36549916
67spliceosomal snRNP assembly (GO:0000387)3.35887422
68inner mitochondrial membrane organization (GO:0007007)3.35720789
69protein localization to mitochondrion (GO:0070585)3.34218815
70establishment of protein localization to mitochondrion (GO:0072655)3.33788436
71oxidative phosphorylation (GO:0006119)3.31977624
72purine nucleoside triphosphate biosynthetic process (GO:0009145)3.31062589
73signal transduction involved in DNA damage checkpoint (GO:0072422)3.29812949
74signal transduction involved in DNA integrity checkpoint (GO:0072401)3.29812949
75cellular component biogenesis (GO:0044085)3.28588565
76signal transduction involved in cell cycle checkpoint (GO:0072395)3.28417682
77purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.27726197
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.22337334
79platelet dense granule organization (GO:0060155)3.17374375
80intracellular protein transmembrane import (GO:0044743)3.13381749
81proton transport (GO:0015992)3.09542533
82protein complex disassembly (GO:0043241)3.09035614
83positive regulation of ligase activity (GO:0051351)3.05117089
84establishment of viral latency (GO:0019043)3.03677717
85hydrogen transport (GO:0006818)3.03229915
86macromolecular complex disassembly (GO:0032984)3.02581559
87histone exchange (GO:0043486)3.00616962
88kinetochore assembly (GO:0051382)3.00030921
89DNA double-strand break processing (GO:0000729)2.98504571
90ribonucleoside triphosphate biosynthetic process (GO:0009201)2.96075417
91pseudouridine synthesis (GO:0001522)2.95339315
92protein targeting to membrane (GO:0006612)2.93729120
93nuclear-transcribed mRNA catabolic process (GO:0000956)2.93420892
94mitochondrial transport (GO:0006839)2.93003227
95water-soluble vitamin biosynthetic process (GO:0042364)2.92257415
96peptidyl-histidine modification (GO:0018202)2.91982498
97DNA replication checkpoint (GO:0000076)2.91254877
98regulation of mitotic spindle checkpoint (GO:1903504)2.90734581
99regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.90734581
100purine nucleobase biosynthetic process (GO:0009113)2.90334287

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.14188723
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.81524874
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.53946450
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.11522020
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.38654378
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.32514533
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.27732880
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.20202159
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.14189465
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.06541805
11ELK1_19687146_ChIP-ChIP_HELA_Human2.94207467
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.69734584
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69174994
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62666780
15VDR_23849224_ChIP-Seq_CD4+_Human2.62032916
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47547352
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34971662
18FOXP3_21729870_ChIP-Seq_TREG_Human2.30911551
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.27114106
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.14640539
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12464371
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.11463664
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.05028722
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.03627647
25THAP11_20581084_ChIP-Seq_MESCs_Mouse1.98750572
26DCP1A_22483619_ChIP-Seq_HELA_Human1.94081237
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.92581628
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.90844430
29ZNF274_21170338_ChIP-Seq_K562_Hela1.89357785
30TTF2_22483619_ChIP-Seq_HELA_Human1.87867182
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86143527
32MYC_18940864_ChIP-ChIP_HL60_Human1.81611029
33EWS_26573619_Chip-Seq_HEK293_Human1.80921150
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79555588
35VDR_22108803_ChIP-Seq_LS180_Human1.78502556
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.77692619
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73866690
38XRN2_22483619_ChIP-Seq_HELA_Human1.73353905
39FUS_26573619_Chip-Seq_HEK293_Human1.72845151
40E2F7_22180533_ChIP-Seq_HELA_Human1.72201904
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70135601
42GABP_19822575_ChIP-Seq_HepG2_Human1.62954286
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61492904
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.56464314
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55243652
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54951413
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.52266006
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48319660
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44231881
50ELK1_22589737_ChIP-Seq_MCF10A_Human1.34236225
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.32056488
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31070175
53SOX2_16153702_ChIP-ChIP_HESCs_Human1.29358255
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28930873
55IGF1R_20145208_ChIP-Seq_DFB_Human1.27920369
56TAF15_26573619_Chip-Seq_HEK293_Human1.26137870
57ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.25764115
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25424339
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24446258
60NANOG_16153702_ChIP-ChIP_HESCs_Human1.18478373
61IRF1_19129219_ChIP-ChIP_H3396_Human1.18323842
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17509974
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14298674
64P300_19829295_ChIP-Seq_ESCs_Human1.14165779
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13216245
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12278969
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.11999240
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07105904
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06979388
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06358844
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05742528
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.04176680
73TP53_22573176_ChIP-Seq_HFKS_Human1.03789099
74MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03305935
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01460584
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00397872
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99512718
78CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98677969
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91399298
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91149095
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90411658
82CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88442485
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87762131
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.85439272
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84414894
86NANOG_19829295_ChIP-Seq_ESCs_Human0.83643581
87SOX2_19829295_ChIP-Seq_ESCs_Human0.83643581
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83186255
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81302651
90NANOG_18555785_ChIP-Seq_MESCs_Mouse0.80082484
91KDM5A_27292631_Chip-Seq_BREAST_Human0.76285264
92FOXA1_27270436_Chip-Seq_PROSTATE_Human0.75527003
93FOXA1_25329375_ChIP-Seq_VCAP_Human0.75527003
94HTT_18923047_ChIP-ChIP_STHdh_Human0.73903427
95AR_20517297_ChIP-Seq_VCAP_Human0.73843644
96FOXM1_23109430_ChIP-Seq_U2OS_Human0.73359843
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.72934337
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.72680312
99KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.72452664
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.72320092

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.43257904
2MP0006292_abnormal_olfactory_placode3.21941550
3MP0008058_abnormal_DNA_repair3.09400181
4MP0001529_abnormal_vocalization2.69591808
5MP0006072_abnormal_retinal_apoptosis2.56114075
6MP0003806_abnormal_nucleotide_metabolis2.38044709
7MP0002102_abnormal_ear_morphology2.35350500
8MP0002938_white_spotting2.32140801
9MP0003186_abnormal_redox_activity2.23403158
10MP0008877_abnormal_DNA_methylation2.20548513
11MP0003693_abnormal_embryo_hatching2.18030098
12MP0003880_abnormal_central_pattern2.16312756
13MP0010094_abnormal_chromosome_stability2.15416547
14MP0004957_abnormal_blastocyst_morpholog2.14088931
15MP0003136_yellow_coat_color2.13914266
16MP0003011_delayed_dark_adaptation2.06041274
17MP0006036_abnormal_mitochondrial_physio2.04785716
18MP0003718_maternal_effect2.03362088
19MP0009697_abnormal_copulation2.01482879
20MP0002638_abnormal_pupillary_reflex1.90518741
21MP0001293_anophthalmia1.89511273
22MP0000372_irregular_coat_pigmentation1.86427826
23MP0002736_abnormal_nociception_after1.85179229
24MP0004142_abnormal_muscle_tone1.83797108
25MP0005084_abnormal_gallbladder_morpholo1.75453273
26MP0006035_abnormal_mitochondrial_morpho1.73746333
27MP0008789_abnormal_olfactory_epithelium1.65807046
28MP0003077_abnormal_cell_cycle1.64258457
29MP0006276_abnormal_autonomic_nervous1.60026486
30MP0005253_abnormal_eye_physiology1.57845172
31MP0002837_dystrophic_cardiac_calcinosis1.56345221
32MP0008932_abnormal_embryonic_tissue1.56204970
33MP0003121_genomic_imprinting1.54865608
34MP0004133_heterotaxia1.52246568
35MP0001984_abnormal_olfaction1.49345623
36MP0010030_abnormal_orbit_morphology1.48813649
37MP0003786_premature_aging1.47661328
38MP0002234_abnormal_pharynx_morphology1.45836412
39MP0003941_abnormal_skin_development1.45199471
40MP0003111_abnormal_nucleus_morphology1.40605112
41MP0005551_abnormal_eye_electrophysiolog1.39453947
42MP0008995_early_reproductive_senescence1.33219093
43MP0002277_abnormal_respiratory_mucosa1.32428843
44MP0002163_abnormal_gland_morphology1.31726180
45MP0003787_abnormal_imprinting1.25114263
46MP0003567_abnormal_fetal_cardiomyocyte1.23446759
47MP0003890_abnormal_embryonic-extraembry1.23013549
48MP0001968_abnormal_touch/_nociception1.23013415
49MP0000631_abnormal_neuroendocrine_gland1.20424785
50MP0001764_abnormal_homeostasis1.19799314
51MP0008007_abnormal_cellular_replicative1.19767494
52MP0001905_abnormal_dopamine_level1.19314508
53MP0009046_muscle_twitch1.17615756
54MP0000049_abnormal_middle_ear1.15298243
55MP0002653_abnormal_ependyma_morphology1.14839174
56MP0005394_taste/olfaction_phenotype1.13679304
57MP0005499_abnormal_olfactory_system1.13679304
58MP0004147_increased_porphyrin_level1.13131976
59MP0010386_abnormal_urinary_bladder1.11873189
60MP0002160_abnormal_reproductive_system1.10382933
61MP0001485_abnormal_pinna_reflex1.07906163
62MP0002751_abnormal_autonomic_nervous1.07325172
63MP0003937_abnormal_limbs/digits/tail_de1.06998012
64MP0003123_paternal_imprinting1.06398556
65MP0008872_abnormal_physiological_respon1.05812295
66MP0003315_abnormal_perineum_morphology1.05425781
67MP0004215_abnormal_myocardial_fiber1.05424332
68MP0003122_maternal_imprinting1.04888367
69MP0002272_abnormal_nervous_system1.03784362
70MP0002233_abnormal_nose_morphology1.03153619
71MP0003195_calcinosis1.02665949
72MP0002210_abnormal_sex_determination1.00779396
73MP0009745_abnormal_behavioral_response0.97900687
74MP0001286_abnormal_eye_development0.97412694
75MP0002282_abnormal_trachea_morphology0.95337117
76MP0003119_abnormal_digestive_system0.94935122
77MP0005389_reproductive_system_phenotype0.94699930
78MP0001188_hyperpigmentation0.93811151
79MP0003938_abnormal_ear_development0.92349123
80MP0005391_vision/eye_phenotype0.92149447
81MP0005379_endocrine/exocrine_gland_phen0.89214288
82MP0002095_abnormal_skin_pigmentation0.89107922
83MP0001145_abnormal_male_reproductive0.83463320
84MP0000653_abnormal_sex_gland0.82939773
85MP0001929_abnormal_gametogenesis0.82935565
86MP0005195_abnormal_posterior_eye0.81902575
87MP0004145_abnormal_muscle_electrophysio0.81716809
88MP0004742_abnormal_vestibular_system0.80232375
89MP0001486_abnormal_startle_reflex0.79993288
90MP0002822_catalepsy0.79846291
91MP0003283_abnormal_digestive_organ0.79803991
92MP0002752_abnormal_somatic_nervous0.79312831
93MP0005645_abnormal_hypothalamus_physiol0.78878620
94MP0000778_abnormal_nervous_system0.78799206
95MP0003646_muscle_fatigue0.78487754
96MP0005646_abnormal_pituitary_gland0.73066474
97MP0000026_abnormal_inner_ear0.72967926
98MP0000647_abnormal_sebaceous_gland0.72792215
99MP0000358_abnormal_cell_content/0.72681696
100MP0003137_abnormal_impulse_conducting0.71073329

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.67897272
2Abnormal mitochondria in muscle tissue (HP:0008316)5.13574488
3Mitochondrial inheritance (HP:0001427)5.12870980
4Acute encephalopathy (HP:0006846)4.91023411
5Increased hepatocellular lipid droplets (HP:0006565)4.74759633
6Progressive macrocephaly (HP:0004481)4.74632216
7Increased CSF lactate (HP:0002490)4.62819709
8Hepatocellular necrosis (HP:0001404)4.47083278
9Lipid accumulation in hepatocytes (HP:0006561)4.28801270
10Hepatic necrosis (HP:0002605)4.08245896
11Renal Fanconi syndrome (HP:0001994)3.86998745
12Cerebral edema (HP:0002181)3.70861088
13Abnormal number of erythroid precursors (HP:0012131)3.51721547
14Abnormality of cells of the erythroid lineage (HP:0012130)3.46740640
153-Methylglutaconic aciduria (HP:0003535)3.46190411
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.43850275
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.43850275
18Increased intramyocellular lipid droplets (HP:0012240)3.28791242
19Macrocytic anemia (HP:0001972)3.17268408
20Reticulocytopenia (HP:0001896)3.06664933
21Exertional dyspnea (HP:0002875)3.04142778
22Lactic acidosis (HP:0003128)3.03333032
23Increased serum lactate (HP:0002151)3.01100057
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.96173102
25Colon cancer (HP:0003003)2.84136117
26Respiratory failure (HP:0002878)2.84129392
27Optic disc pallor (HP:0000543)2.75308139
28Congenital, generalized hypertrichosis (HP:0004540)2.74990842
29Leukodystrophy (HP:0002415)2.74435624
30Exercise intolerance (HP:0003546)2.73578675
31Methylmalonic acidemia (HP:0002912)2.72680358
32Pancreatic cysts (HP:0001737)2.69601535
33Increased muscle lipid content (HP:0009058)2.63319549
34Abnormality of the labia minora (HP:0012880)2.60419788
35Pancreatic fibrosis (HP:0100732)2.55084220
36Respiratory difficulties (HP:0002880)2.53384105
37Type I transferrin isoform profile (HP:0003642)2.53365567
38Molar tooth sign on MRI (HP:0002419)2.52554659
39Abnormality of midbrain morphology (HP:0002418)2.52554659
40Aplastic anemia (HP:0001915)2.52496971
41Medial flaring of the eyebrow (HP:0010747)2.49017436
42Abnormality of renal resorption (HP:0011038)2.46051217
43True hermaphroditism (HP:0010459)2.40907209
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.34009786
45Methylmalonic aciduria (HP:0012120)2.29755063
46Septo-optic dysplasia (HP:0100842)2.29369204
47Lethargy (HP:0001254)2.24344524
48Nephronophthisis (HP:0000090)2.18096612
49Abnormality of alanine metabolism (HP:0010916)2.18038226
50Hyperalaninemia (HP:0003348)2.18038226
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18038226
52CNS demyelination (HP:0007305)2.17298602
53Increased serum pyruvate (HP:0003542)2.16992007
54Pallor (HP:0000980)2.16253594
55Hyperglycinemia (HP:0002154)2.08915768
56Glycosuria (HP:0003076)2.03634667
57Abnormality of urine glucose concentration (HP:0011016)2.03634667
58Abnormality of serum amino acid levels (HP:0003112)2.03449566
59X-linked dominant inheritance (HP:0001423)2.03278748
60Stenosis of the external auditory canal (HP:0000402)1.99790843
61Oral leukoplakia (HP:0002745)1.99495366
62Congenital primary aphakia (HP:0007707)1.98797271
63Meckel diverticulum (HP:0002245)1.98593391
64Abnormality of methionine metabolism (HP:0010901)1.96776734
65Gait imbalance (HP:0002141)1.95285295
66Generalized aminoaciduria (HP:0002909)1.94665269
67Abnormality of the ileum (HP:0001549)1.92441791
68Sclerocornea (HP:0000647)1.92005030
69Abnormality of the anterior horn cell (HP:0006802)1.91539442
70Degeneration of anterior horn cells (HP:0002398)1.91539442
71Abnormal protein glycosylation (HP:0012346)1.90854281
72Abnormal glycosylation (HP:0012345)1.90854281
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90854281
74Abnormal protein N-linked glycosylation (HP:0012347)1.90854281
75Aplasia/Hypoplasia of the uvula (HP:0010293)1.89786203
76Nephrogenic diabetes insipidus (HP:0009806)1.88706574
77Hyperphosphaturia (HP:0003109)1.87779177
78Abnormal lung lobation (HP:0002101)1.84396704
79Triphalangeal thumb (HP:0001199)1.81454193
80Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81406486
81Reduced antithrombin III activity (HP:0001976)1.78502585
82Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77299734
83Abnormality of the renal medulla (HP:0100957)1.76925865
84Hypothermia (HP:0002045)1.76461537
85Microvesicular hepatic steatosis (HP:0001414)1.76455776
86Abnormality of glycolysis (HP:0004366)1.76038811
87Absent septum pellucidum (HP:0001331)1.73312478
88Genital tract atresia (HP:0001827)1.73046122
89Myokymia (HP:0002411)1.72578692
90Amniotic constriction ring (HP:0009775)1.70416739
91Abnormality of placental membranes (HP:0011409)1.70416739
92Vaginal atresia (HP:0000148)1.70299178
93Volvulus (HP:0002580)1.69621638
94Poor suck (HP:0002033)1.69364170
95Supernumerary spleens (HP:0009799)1.69125686
96Emotional lability (HP:0000712)1.69124945
97Pancytopenia (HP:0001876)1.67744801
98Bilateral microphthalmos (HP:0007633)1.64468403
99Aplasia/Hypoplasia of the tongue (HP:0010295)1.64408701
100Anencephaly (HP:0002323)1.63169474

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.21119372
2STK163.63117002
3BUB13.17735350
4ZAK2.77158544
5SRPK12.63795137
6VRK12.60577824
7MAP4K22.54784910
8MAP3K122.46916622
9CDC72.43789444
10MST42.31217362
11PBK2.21785474
12NME12.16598367
13NUAK12.08257781
14WNK31.99959630
15PLK41.89462810
16BMPR1B1.71401290
17PLK31.69762154
18NEK11.69684811
19DYRK21.68539501
20EIF2AK31.61057979
21BCKDK1.53996696
22TNIK1.51322903
23TRIM281.49603237
24TLK11.49463716
25EIF2AK11.41032665
26TAF11.39013669
27MKNK11.31863906
28ADRBK21.26488684
29CDK191.23529449
30TTK1.21990723
31WEE11.18755822
32GRK11.17969647
33MKNK21.14644452
34PDK21.13594099
35TSSK61.13546574
36MAP2K71.12332603
37MAP3K41.10043031
38INSRR1.09710039
39PLK11.09411805
40NME21.08080271
41CSNK1G31.00515923
42LIMK10.99957176
43CSNK1G10.97042383
44DYRK30.96202619
45CASK0.94758302
46OXSR10.94429921
47CSNK1G20.93989968
48PASK0.93380340
49BCR0.92710728
50MAPK130.89898216
51BRSK20.88329988
52AURKB0.87853131
53PINK10.87007085
54ERBB30.86604138
55PLK20.77798755
56FRK0.76417019
57CSNK1A1L0.72960201
58CCNB10.71984428
59TAOK30.70384925
60PRKCG0.68229266
61CHEK20.65427593
62AURKA0.65161392
63ATR0.64991388
64CDK80.63737849
65MYLK0.63497851
66OBSCN0.62845446
67STK38L0.62742408
68RPS6KA50.61824831
69CSNK2A10.61472298
70CSNK2A20.60697993
71TIE10.55705124
72WNK40.54645635
73MAPKAPK50.54218422
74PHKG10.53561980
75PHKG20.53561980
76PNCK0.53191636
77EPHA40.51762125
78ACVR1B0.50409837
79MINK10.50219899
80TGFBR10.49302215
81PRKCE0.49257592
82ILK0.48632540
83MARK10.48136994
84BRSK10.47270617
85EIF2AK20.45594492
86KDR0.45527910
87DAPK30.44793466
88ABL20.41612127
89MUSK0.41536177
90TESK20.41398171
91ATM0.41339529
92CDK30.41233860
93RPS6KA40.37897042
94STK40.37568654
95DAPK10.35980316
96EPHB20.35108000
97PAK30.33717013
98GRK70.33689606
99CSNK1E0.33572682
100CSNK1A10.33488825

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.65783563
2Ribosome_Homo sapiens_hsa030104.56804418
3Proteasome_Homo sapiens_hsa030504.33995637
4Parkinsons disease_Homo sapiens_hsa050124.02093944
5Protein export_Homo sapiens_hsa030603.25284435
6RNA polymerase_Homo sapiens_hsa030203.01098700
7Huntingtons disease_Homo sapiens_hsa050162.82809265
8Alzheimers disease_Homo sapiens_hsa050102.68091559
9Mismatch repair_Homo sapiens_hsa034302.60791668
10Homologous recombination_Homo sapiens_hsa034402.36365128
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.26268388
12DNA replication_Homo sapiens_hsa030302.23913908
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.16343973
14Spliceosome_Homo sapiens_hsa030401.96889574
15Cardiac muscle contraction_Homo sapiens_hsa042601.95515385
16Nucleotide excision repair_Homo sapiens_hsa034201.78313880
17Basal transcription factors_Homo sapiens_hsa030221.76848220
18Base excision repair_Homo sapiens_hsa034101.63003774
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60425961
20RNA degradation_Homo sapiens_hsa030181.59769204
21Pyrimidine metabolism_Homo sapiens_hsa002401.57630023
22Fanconi anemia pathway_Homo sapiens_hsa034601.55104444
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53194211
24Non-homologous end-joining_Homo sapiens_hsa034501.44719423
25RNA transport_Homo sapiens_hsa030131.39832868
26Propanoate metabolism_Homo sapiens_hsa006401.33940027
27One carbon pool by folate_Homo sapiens_hsa006701.33344237
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30483354
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30133065
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29210357
31Purine metabolism_Homo sapiens_hsa002301.20218165
32Folate biosynthesis_Homo sapiens_hsa007901.19658886
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17486152
34Pyruvate metabolism_Homo sapiens_hsa006201.15067885
35Fatty acid elongation_Homo sapiens_hsa000621.13317491
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08517366
37Glutathione metabolism_Homo sapiens_hsa004800.93447499
38Steroid biosynthesis_Homo sapiens_hsa001000.92416857
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.90027788
40Collecting duct acid secretion_Homo sapiens_hsa049660.88085323
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86906782
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85890524
43Butanoate metabolism_Homo sapiens_hsa006500.84882511
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82737605
45Phototransduction_Homo sapiens_hsa047440.82122833
46Cell cycle_Homo sapiens_hsa041100.81476890
47Metabolic pathways_Homo sapiens_hsa011000.80558247
48Peroxisome_Homo sapiens_hsa041460.78220916
49Selenocompound metabolism_Homo sapiens_hsa004500.70581255
50Tryptophan metabolism_Homo sapiens_hsa003800.70252001
51Nicotine addiction_Homo sapiens_hsa050330.64651623
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61818827
53Sulfur relay system_Homo sapiens_hsa041220.59620131
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58080482
55Regulation of autophagy_Homo sapiens_hsa041400.57860798
56Sulfur metabolism_Homo sapiens_hsa009200.57734559
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54206167
58Carbon metabolism_Homo sapiens_hsa012000.51053242
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50816600
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50424081
61Nitrogen metabolism_Homo sapiens_hsa009100.50150837
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49685048
63Chemical carcinogenesis_Homo sapiens_hsa052040.49460809
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49064426
65Systemic lupus erythematosus_Homo sapiens_hsa053220.48577592
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47787962
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.46888057
68Oocyte meiosis_Homo sapiens_hsa041140.43114711
69Fatty acid degradation_Homo sapiens_hsa000710.40652518
70beta-Alanine metabolism_Homo sapiens_hsa004100.38723343
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.36325181
72mRNA surveillance pathway_Homo sapiens_hsa030150.36317216
73Biosynthesis of amino acids_Homo sapiens_hsa012300.35857615
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34082417
75p53 signaling pathway_Homo sapiens_hsa041150.33958305
76Retinol metabolism_Homo sapiens_hsa008300.33178896
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33138042
78Asthma_Homo sapiens_hsa053100.32928312
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.32485566
80Linoleic acid metabolism_Homo sapiens_hsa005910.30920919
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30429163
82N-Glycan biosynthesis_Homo sapiens_hsa005100.29864953
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29657920
84Caffeine metabolism_Homo sapiens_hsa002320.28853434
85Vitamin digestion and absorption_Homo sapiens_hsa049770.28185126
86Epstein-Barr virus infection_Homo sapiens_hsa051690.28177928
87Fatty acid metabolism_Homo sapiens_hsa012120.27331586
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27264963
89Basal cell carcinoma_Homo sapiens_hsa052170.26319071
90Arginine and proline metabolism_Homo sapiens_hsa003300.26205444
91Hedgehog signaling pathway_Homo sapiens_hsa043400.24793285
92Alcoholism_Homo sapiens_hsa050340.24020765
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.21488614
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.20900605
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20181438
96Olfactory transduction_Homo sapiens_hsa047400.19686848
97Tyrosine metabolism_Homo sapiens_hsa003500.18875142
98Arachidonic acid metabolism_Homo sapiens_hsa005900.17413495
99Rheumatoid arthritis_Homo sapiens_hsa053230.16991879
100Taste transduction_Homo sapiens_hsa047420.16287463

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