HILS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is expressed in nuclei of late maturing spermatids. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.96644209
2plasma membrane fusion (GO:0045026)9.64737888
3response to pheromone (GO:0019236)9.55396823
4epithelial cilium movement (GO:0003351)9.49159880
5axonemal dynein complex assembly (GO:0070286)9.46608553
6motile cilium assembly (GO:0044458)9.32943198
7reproduction (GO:0000003)9.32163873
8regulation of cilium movement (GO:0003352)8.51669550
9cilium or flagellum-dependent cell motility (GO:0001539)7.69431513
10cilium movement (GO:0003341)7.65867881
11negative regulation of inclusion body assembly (GO:0090084)7.48996236
12sperm capacitation (GO:0048240)7.36767186
13single fertilization (GO:0007338)7.18851196
14synaptonemal complex organization (GO:0070193)7.18207570
15synaptonemal complex assembly (GO:0007130)7.14163711
16organic cation transport (GO:0015695)7.02085964
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.97902522
18male meiosis (GO:0007140)6.85616906
19* spermatogenesis (GO:0007283)6.85323025
20* male gamete generation (GO:0048232)6.82757506
21piRNA metabolic process (GO:0034587)6.48318474
22microtubule depolymerization (GO:0007019)6.42035346
23* gamete generation (GO:0007276)6.27018928
24regulation of inclusion body assembly (GO:0090083)6.25650296
25fertilization (GO:0009566)6.13927899
26rRNA methylation (GO:0031167)6.05967230
27phosphatidylethanolamine biosynthetic process (GO:0006646)5.91055241
28calcium ion-dependent exocytosis (GO:0017156)5.82558278
29spermatid nucleus differentiation (GO:0007289)5.80340385
30protein targeting to Golgi (GO:0000042)5.46414587
31phosphatidylethanolamine metabolic process (GO:0046337)5.45770129
32* cellular process involved in reproduction in multicellular organism (GO:0022412)5.31495903
33* germ cell development (GO:0007281)5.21467530
34establishment of protein localization to Golgi (GO:0072600)5.20775726
35cell recognition (GO:0008037)5.20621457
36microtubule severing (GO:0051013)5.11334930
37retrograde transport, vesicle recycling within Golgi (GO:0000301)5.10120304
38glycerol ether metabolic process (GO:0006662)5.09658255
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.05521221
40regulation of microtubule-based movement (GO:0060632)5.00856222
41centriole replication (GO:0007099)4.98495845
42ventricular system development (GO:0021591)4.95754406
43rRNA modification (GO:0000154)4.95342799
44cellular ketone body metabolic process (GO:0046950)4.93288576
45* multicellular organismal reproductive process (GO:0048609)4.91833259
46sexual reproduction (GO:0019953)4.91380783
47* chromosome condensation (GO:0030261)4.80430426
48chromosome organization involved in meiosis (GO:0070192)4.78966584
49ketone body metabolic process (GO:1902224)4.75156392
50positive regulation of Rab GTPase activity (GO:0032851)4.71804217
51regulation of Rab GTPase activity (GO:0032313)4.71804217
52* DNA packaging (GO:0006323)4.71701422
53ether metabolic process (GO:0018904)4.71000724
54seminiferous tubule development (GO:0072520)4.70336035
55single strand break repair (GO:0000012)4.56460684
56male meiosis I (GO:0007141)4.51795432
57coenzyme catabolic process (GO:0009109)4.27601589
58negative regulation of Rho protein signal transduction (GO:0035024)4.25086644
59DNA methylation involved in gamete generation (GO:0043046)4.22359310
60left/right pattern formation (GO:0060972)4.20953828
61sequestering of actin monomers (GO:0042989)4.16593049
62musculoskeletal movement (GO:0050881)4.14822116
63multicellular organismal movement (GO:0050879)4.14822116
64centriole assembly (GO:0098534)4.14321883
65chaperone-mediated protein complex assembly (GO:0051131)4.13989228
66meiotic nuclear division (GO:0007126)4.10517268
67regulation of transcription involved in cell fate commitment (GO:0060850)4.04465803
68protein localization to Golgi apparatus (GO:0034067)3.95283729
69* multicellular organismal development (GO:0007275)3.95084702
70cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.75293209
71protein polyglutamylation (GO:0018095)3.75126581
72melanin biosynthetic process (GO:0042438)3.65265541
73meiosis I (GO:0007127)3.58564437
74protein K11-linked deubiquitination (GO:0035871)3.57710997
75positive regulation of myotube differentiation (GO:0010831)3.54780452
76regulation of centriole replication (GO:0046599)3.54270039
77positive regulation of macrophage activation (GO:0043032)3.46413874
78regulation of spindle checkpoint (GO:0090231)3.45640749
79genitalia morphogenesis (GO:0035112)3.45446522
80muscle organ morphogenesis (GO:0048644)3.39654938
81amino-acid betaine transport (GO:0015838)3.31486748
82carnitine transport (GO:0015879)3.31486748
83interferon-gamma secretion (GO:0072643)3.30474758
84melanin metabolic process (GO:0006582)3.30283017
85protein refolding (GO:0042026)3.28334282
86microtubule polymerization or depolymerization (GO:0031109)3.27092908
87actin-myosin filament sliding (GO:0033275)3.25776046
88muscle filament sliding (GO:0030049)3.25776046
89regulation of somitogenesis (GO:0014807)3.22152219
90peptidyl-proline hydroxylation (GO:0019511)3.21453622
91nucleus organization (GO:0006997)3.20627787
92protein depolymerization (GO:0051261)3.18531837
93vesicle transport along microtubule (GO:0047496)3.16932408
94carnitine transmembrane transport (GO:1902603)3.15327969
95response to acidic pH (GO:0010447)3.14915883
96glycolytic process (GO:0006096)3.14027885
97meiotic cell cycle (GO:0051321)3.12259066
98positive regulation of skeletal muscle tissue development (GO:0048643)3.11306362
99cranial nerve morphogenesis (GO:0021602)3.09853071
100RNA localization (GO:0006403)3.09126178
101monoubiquitinated protein deubiquitination (GO:0035520)3.08803572
102polyamine biosynthetic process (GO:0006596)3.05161156
103RNA destabilization (GO:0050779)3.04735149
104myoblast fusion (GO:0007520)3.00438087
105protein localization to cilium (GO:0061512)3.00427021
106mitotic sister chromatid cohesion (GO:0007064)3.00154695
107glomerular visceral epithelial cell development (GO:0072015)2.98854003
108peptidyl-threonine dephosphorylation (GO:0035970)2.92260366
109regulation of ARF GTPase activity (GO:0032312)2.92012956
110secondary metabolite biosynthetic process (GO:0044550)2.91616708
111muscle cell fate commitment (GO:0042693)2.91577237
112alanine transport (GO:0032328)2.91490953
113negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.91440909
114histone H3-K9 demethylation (GO:0033169)2.90426322
115skeletal muscle contraction (GO:0003009)2.90282200
116cellular response to pH (GO:0071467)2.89719194
117metanephric mesenchyme development (GO:0072075)2.89476636
118nucleoside diphosphate phosphorylation (GO:0006165)2.86300052
119glomerular epithelial cell development (GO:0072310)2.84630862
120polyol catabolic process (GO:0046174)2.84319815
121cerebral cortex neuron differentiation (GO:0021895)2.80394755
122protein-DNA complex disassembly (GO:0032986)2.75656886
123nucleosome disassembly (GO:0006337)2.75656886
124regulation of T-helper 2 cell differentiation (GO:0045628)2.74737528
125synapsis (GO:0007129)2.73920813
126regulation of interleukin-13 production (GO:0032656)2.73125184
127alditol metabolic process (GO:0019400)2.72849062
128syncytium formation by plasma membrane fusion (GO:0000768)2.72159868
129meiotic cell cycle process (GO:1903046)2.69756091
130cilium organization (GO:0044782)2.67989929
131regulation of cilium assembly (GO:1902017)2.67702103
132cellular component assembly involved in morphogenesis (GO:0010927)2.62621234
133mitochondrion degradation (GO:0000422)2.57844218
134peptidyl-glutamic acid modification (GO:0018200)2.56932573
135microtubule-based movement (GO:0007018)2.56406751
136GTP biosynthetic process (GO:0006183)2.56313211
137cilium assembly (GO:0042384)2.56250863
138cilium morphogenesis (GO:0060271)2.55610345
139axoneme assembly (GO:0035082)2.47709072
140negative regulation of organelle assembly (GO:1902116)2.44618366
141intraciliary transport (GO:0042073)2.44145375
142membrane protein intracellular domain proteolysis (GO:0031293)2.42596915
143lactate metabolic process (GO:0006089)2.38856241
144sperm motility (GO:0030317)14.2613440
145cell wall macromolecule metabolic process (GO:0044036)14.1863698
146cell wall macromolecule catabolic process (GO:0016998)14.1863698
147acrosome reaction (GO:0007340)12.7368297
148fusion of sperm to egg plasma membrane (GO:0007342)12.6595593
149acrosome assembly (GO:0001675)12.1127372
150sperm-egg recognition (GO:0035036)11.9475128
151binding of sperm to zona pellucida (GO:0007339)10.9207695
152cell-cell recognition (GO:0009988)10.7041063
153multicellular organism reproduction (GO:0032504)10.5810189

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.12212270
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.03300161
3EZH2_22144423_ChIP-Seq_EOC_Human4.00238735
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.96580541
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.53289268
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.51025973
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.99097793
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.93213731
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.84057402
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.84033923
11VDR_22108803_ChIP-Seq_LS180_Human2.49995334
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.31624426
13* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.25394727
14ZNF274_21170338_ChIP-Seq_K562_Hela2.06009029
15EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.05707112
16DROSHA_22980978_ChIP-Seq_HELA_Human2.02459795
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94948351
18KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.88638482
19CTCF_27219007_Chip-Seq_Bcells_Human1.87832783
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.87193169
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85408218
22FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81889279
23ELK4_26923725_Chip-Seq_MESODERM_Mouse1.77793653
24* ERA_21632823_ChIP-Seq_H3396_Human1.71959495
25TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.70768381
26STAT1_17558387_ChIP-Seq_HELA_Human1.70546781
27RAC3_21632823_ChIP-Seq_H3396_Human1.68844397
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67531316
29MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.66663622
30GATA3_21867929_ChIP-Seq_CD8_Mouse1.66446333
31* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.62908729
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61154179
33NANOG_20526341_ChIP-Seq_ESCs_Human1.59168764
34GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.56559706
35SMC4_20622854_ChIP-Seq_HELA_Human1.56546453
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54846076
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54084221
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52179925
39ER_23166858_ChIP-Seq_MCF-7_Human1.51056741
40EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.50865261
41LXR_22292898_ChIP-Seq_THP-1_Human1.50362607
42FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.49688390
43E2F1_20622854_ChIP-Seq_HELA_Human1.49114957
44BCL6_27268052_Chip-Seq_Bcells_Human1.48698100
45AUTS2_25519132_ChIP-Seq_293T-REX_Human1.48513976
46MYC_19829295_ChIP-Seq_ESCs_Human1.48071737
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.46655281
48OCT4_20526341_ChIP-Seq_ESCs_Human1.45903920
49FUS_26573619_Chip-Seq_HEK293_Human1.45518958
50PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.45505119
51RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45275646
52WDR5_24793694_ChIP-Seq_LNCAP_Human1.44194879
53SMAD4_21741376_ChIP-Seq_EPCs_Human1.43958860
54TDRD3_21172665_ChIP-Seq_MCF-7_Human1.43853587
55P68_20966046_ChIP-Seq_HELA_Human1.42750832
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.41546052
57TAL1_26923725_Chip-Seq_HPCs_Mouse1.40632737
58CBP_20019798_ChIP-Seq_JUKART_Human1.40386846
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40386846
60LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.38585394
61* KDM2B_26808549_Chip-Seq_REH_Human1.38579477
62P53_21459846_ChIP-Seq_SAOS-2_Human1.37980279
63AR_21572438_ChIP-Seq_LNCaP_Human1.37856532
64* TP63_22573176_ChIP-Seq_HFKS_Human1.37763597
65TP53_18474530_ChIP-ChIP_U2OS_Human1.37415652
66KAP1_22055183_ChIP-Seq_ESCs_Mouse1.36602725
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36312493
68* TAF2_19829295_ChIP-Seq_ESCs_Human1.35857534
69SMAD3_21741376_ChIP-Seq_ESCs_Human1.35188388
70VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.34499523
71SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.33904843
72REST_21632747_ChIP-Seq_MESCs_Mouse1.32574804
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.32033649
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28325443
75AR_25329375_ChIP-Seq_VCAP_Human1.28286277
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28219999
77GATA3_21867929_ChIP-Seq_TH1_Mouse1.27973464
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27009589
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.26614767
80PHF8_20622854_ChIP-Seq_HELA_Human1.25471580
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.25175232
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24764678
83GF1_26923725_Chip-Seq_HPCs_Mouse1.24597019
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24583111
85SMAD4_21741376_ChIP-Seq_HESCs_Human1.24037829
86NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23189491
87SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.22512075
88CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22118790
89HNFA_21074721_ChIP-Seq_CACO-2_Human1.22073487
90CBX2_22325352_ChIP-Seq_293T-Rex_Human1.21550655
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21474962
92CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19965180
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.19336552
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18906347
95SPI1_26923725_Chip-Seq_HPCs_Mouse1.18778365
96CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.18246235
97SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18218827
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.16996347
99GATA3_21878914_ChIP-Seq_MCF-7_Human1.16742542
100* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.16191892
101RBPJ_21746931_ChIP-Seq_IB4_Human1.15032783
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14200716
103EZH2_27304074_Chip-Seq_ESCs_Mouse1.14070575
104TET1_21451524_ChIP-Seq_MESCs_Mouse1.14065924
105RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13925618
106SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13073491
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12295198
108RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12031780
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11671213
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11671213
111P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.11351248
112MYC_27129775_Chip-Seq_CORNEA_Mouse1.10510097
113P300_19829295_ChIP-Seq_ESCs_Human1.10361680
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10147056
115TBL1_22424771_ChIP-Seq_293T_Human1.09726967
116ESET_19884257_ChIP-Seq_ESCs_Mouse1.09198238
117RARA_24833708_ChIP-Seq_LIVER_Mouse1.09124468
118PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09017388
119ERG_20517297_ChIP-Seq_VCAP_Human1.08777083
120* SA1_27219007_Chip-Seq_Bcells_Human1.08570308
121RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08567272
122TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08017991
123ETV1_20927104_ChIP-Seq_GIST48_Human1.07033569
124KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06355849
125YY1_22570637_ChIP-Seq_MALME-3M_Human1.05426289
126SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05298405
127* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.05271553
128* CEBPB_22108803_ChIP-Seq_LS180_Human1.04591760
129PHF8_20622853_ChIP-Seq_HELA_Human1.03787969
130JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.03783460
131NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03674748
132SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03379682
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03255414
134CRX_20693478_ChIP-Seq_RETINA_Mouse1.03084669
135P300_27268052_Chip-Seq_Bcells_Human1.02650639
136PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02598157
137EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02240260
138JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01658683
139MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01502224
140SA1_27219007_Chip-Seq_ERYTHROID_Human1.01361108
141NANOG_18555785_Chip-Seq_ESCs_Mouse1.01001193
142PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00634401
143SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99793789
144RUNX1_27514584_Chip-Seq_MCF-7_Human0.99632915
145CSB_26484114_Chip-Seq_FIBROBLAST_Human0.98754501
146ELF1_20517297_ChIP-Seq_JURKAT_Human0.98073479
147SOX11_22085726_ChIP-Seq_ESNs_Mouse0.97589591
148RUNX_20019798_ChIP-Seq_JUKART_Human0.97257343
149CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97069019
150CTCF_20526341_ChIP-Seq_ESCs_Human0.96989702
151* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96910862
152SMAD4_21799915_ChIP-Seq_A2780_Human0.96153551
153OCT4_18555785_Chip-Seq_ESCs_Mouse0.95338973
154* LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94782426
155KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.94272171
156BCOR_27268052_Chip-Seq_Bcells_Human0.94257469
157SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92263441
158P53_22387025_ChIP-Seq_ESCs_Mouse0.92076063
159ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90136927
160CMYC_18555785_Chip-Seq_ESCs_Mouse0.88275626
161NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87374437
162SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87232614
163SOX9_26525672_Chip-Seq_HEART_Mouse0.87054671
164RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.86935732
165* FLI1_21867929_ChIP-Seq_CD8_Mouse0.86647643
166OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86588210
167NFYB_21822215_ChIP-Seq_K562_Human0.86441433

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.03469083
2MP0001929_abnormal_gametogenesis5.51500109
3MP0008877_abnormal_DNA_methylation3.72220374
4MP0002161_abnormal_fertility/fecundity3.27652283
5MP0002210_abnormal_sex_determination3.24963880
6MP0001348_abnormal_lacrimal_gland3.06689042
7MP0003136_yellow_coat_color3.03208618
8MP0005670_abnormal_white_adipose3.00749671
9MP0005171_absent_coat_pigmentation2.97152785
10MP0001145_abnormal_male_reproductive2.78602715
11MP0000653_abnormal_sex_gland2.40275750
12MP0000372_irregular_coat_pigmentation2.25652460
13MP0002653_abnormal_ependyma_morphology2.04632399
14MP0005408_hypopigmentation2.00149546
15MP0005410_abnormal_fertilization16.7980209
16MP0000678_abnormal_parathyroid_gland1.97476492
17MP0003646_muscle_fatigue1.87226377
18MP0000015_abnormal_ear_pigmentation1.76229222
19MP0002249_abnormal_larynx_morphology1.71401660
20MP0004233_abnormal_muscle_weight1.67287608
21MP0005423_abnormal_somatic_nervous1.64880127
22MP0005379_endocrine/exocrine_gland_phen1.58645255
23MP0002160_abnormal_reproductive_system1.50665003
24MP0005451_abnormal_body_composition1.48181603
25MP0000759_abnormal_skeletal_muscle1.44409836
26MP0002132_abnormal_respiratory_system1.43419217
27MP0001486_abnormal_startle_reflex1.36394445
28MP0001485_abnormal_pinna_reflex1.35181065
29MP0004484_altered_response_of1.28724625
30MP0005623_abnormal_meninges_morphology1.27696838
31MP0004859_abnormal_synaptic_plasticity1.22571773
32MP0002127_abnormal_cardiovascular_syste1.22306455
33MP0003718_maternal_effect1.20786658
34MP0004510_myositis1.18745471
35MP0005369_muscle_phenotype1.13917191
36MP0000733_abnormal_muscle_development1.13654392
37MP0005248_abnormal_Harderian_gland1.12543398
38MP0005620_abnormal_muscle_contractility1.10951134
39MP0000003_abnormal_adipose_tissue1.10473733
40MP0001765_abnormal_ion_homeostasis1.07292282
41MP0001984_abnormal_olfaction1.06672499
42MP0002822_catalepsy1.06052471
43MP0002282_abnormal_trachea_morphology1.04509261
44MP0004381_abnormal_hair_follicle1.03440575
45MP0002234_abnormal_pharynx_morphology1.01057890
46MP0002095_abnormal_skin_pigmentation0.96808070
47MP0002735_abnormal_chemical_nociception0.96029603
48MP0001963_abnormal_hearing_physiology0.95349283
49MP0000747_muscle_weakness0.94667625
50MP0000371_diluted_coat_color0.94387047
51MP0002067_abnormal_sensory_capabilities0.93283548
52MP0009053_abnormal_anal_canal0.93138450
53MP0002108_abnormal_muscle_morphology0.92026224
54MP0000026_abnormal_inner_ear0.90555088
55MP0009046_muscle_twitch0.81913731
56MP0005409_darkened_coat_color0.80325687
57MP0000955_abnormal_spinal_cord0.79498617
58MP0008058_abnormal_DNA_repair0.79231650
59MP0002332_abnormal_exercise_endurance0.76842033
60MP0002733_abnormal_thermal_nociception0.76824215
61MP0005174_abnormal_tail_pigmentation0.76045702
62MP0005647_abnormal_sex_gland0.75749747
63MP0004085_abnormal_heartbeat0.73260601
64MP0005075_abnormal_melanosome_morpholog0.73054759
65MP0001299_abnormal_eye_distance/0.72585274
66MP0005389_reproductive_system_phenotype0.72328978
67MP0003115_abnormal_respiratory_system0.70232714
68MP0000049_abnormal_middle_ear0.70132021
69MP0004036_abnormal_muscle_relaxation0.69860954
70MP0002272_abnormal_nervous_system0.65968105
71MP0003137_abnormal_impulse_conducting0.65650135
72MP0003011_delayed_dark_adaptation0.63557892
73MP0001879_abnormal_lymphatic_vessel0.62279401
74MP0005257_abnormal_intraocular_pressure0.61833371
75MP0002972_abnormal_cardiac_muscle0.60632835
76MP0005666_abnormal_adipose_tissue0.59936770
77MP0005636_abnormal_mineral_homeostasis0.59007458
78MP0000750_abnormal_muscle_regeneration0.58799548
79MP0002269_muscular_atrophy0.56805881
80MP0003329_amyloid_beta_deposits0.56663653
81MP0002734_abnormal_mechanical_nocicepti0.55937664
82MP0006036_abnormal_mitochondrial_physio0.55736595
83MP0000681_abnormal_thyroid_gland0.55319034
84MP0002572_abnormal_emotion/affect_behav0.55243378
85MP0001970_abnormal_pain_threshold0.54939304
86MP0005395_other_phenotype0.50862187
87MP0005330_cardiomyopathy0.49845719
88MP0001324_abnormal_eye_pigmentation0.48951027
89MP0008995_early_reproductive_senescence0.48760634
90MP0003635_abnormal_synaptic_transmissio0.48354429
91MP0005377_hearing/vestibular/ear_phenot0.47251500
92MP0003878_abnormal_ear_physiology0.47251500
93MP0002736_abnormal_nociception_after0.46338795
94MP0000358_abnormal_cell_content/0.45241336
95MP0001764_abnormal_homeostasis0.45024891
96MP0003699_abnormal_female_reproductive0.44123917
97MP0000534_abnormal_ureter_morphology0.42759305
98MP0001293_anophthalmia0.42590109
99MP0005397_hematopoietic_system_phenotyp0.40083062
100MP0001545_abnormal_hematopoietic_system0.40083062
101MP0004133_heterotaxia0.38942202
102MP0009278_abnormal_bone_marrow0.38933573
103MP0002928_abnormal_bile_duct0.38185199
104MP0005253_abnormal_eye_physiology0.35767188
105MP0009115_abnormal_fat_cell0.35639511
106MP0003950_abnormal_plasma_membrane0.34559859
107MP0005551_abnormal_eye_electrophysiolog0.33581018
108MP0010094_abnormal_chromosome_stability0.33020725
109MP0003633_abnormal_nervous_system0.32183002
110MP0004811_abnormal_neuron_physiology0.31888452
111MP0004145_abnormal_muscle_electrophysio0.31488962
112MP0000751_myopathy0.29909751
113MP0000569_abnormal_digit_pigmentation0.29507158
114MP0006035_abnormal_mitochondrial_morpho0.29069619
115MP0002971_abnormal_brown_adipose0.28576924
116MP0000604_amyloidosis0.28401463
117MP0003942_abnormal_urinary_system0.28233334
118MP0002139_abnormal_hepatobiliary_system0.27315724
119MP0005391_vision/eye_phenotype0.26056704
120MP0004084_abnormal_cardiac_muscle0.25603698
121MP0001730_embryonic_growth_arrest0.25567524
122MP0002169_no_abnormal_phenotype0.24780435
123MP0001968_abnormal_touch/_nociception0.24632514
124MP0002873_normal_phenotype0.24544698
125MP0003948_abnormal_gas_homeostasis0.24414628
126MP0003631_nervous_system_phenotype0.24254554
127MP0003861_abnormal_nervous_system0.23630198
128MP0002152_abnormal_brain_morphology0.21921775
129MP0003787_abnormal_imprinting0.21235104
130MP0004019_abnormal_vitamin_homeostasis0.20651326
131MP0001119_abnormal_female_reproductive0.20323065
132MP0003111_abnormal_nucleus_morphology0.19803098
133MP0003879_abnormal_hair_cell0.19358804
134MP0002295_abnormal_pulmonary_circulatio0.19337704
135MP0001849_ear_inflammation0.19067941
136MP0002106_abnormal_muscle_physiology0.18662019
137MP0004043_abnormal_pH_regulation0.18654925
138MP0004087_abnormal_muscle_fiber0.18244875
139MP0002909_abnormal_adrenal_gland0.18232525
140MP0005375_adipose_tissue_phenotype0.18226591
141MP0008875_abnormal_xenobiotic_pharmacok0.17732811
142MP0004270_analgesia0.17227738
143MP0004130_abnormal_muscle_cell0.16440973
144MP0000749_muscle_degeneration0.16293893
145MP0003959_abnormal_lean_body0.15717982
146MP0005319_abnormal_enzyme/_coenzyme0.15609917
147MP0008569_lethality_at_weaning0.15602458
148MP0000001_mammalian_phenotype0.14915984
149MP0008961_abnormal_basal_metabolism0.14690115
150MP0002102_abnormal_ear_morphology0.14408048
151MP0004742_abnormal_vestibular_system0.13859357
152MP0002229_neurodegeneration0.13777702
153MP0002837_dystrophic_cardiac_calcinosis0.13746971
154MP0001661_extended_life_span0.13709298
155MP0000313_abnormal_cell_death0.13436280
156MP0002693_abnormal_pancreas_physiology0.13424378
157MP0000462_abnormal_digestive_system0.13263507
158MP0002084_abnormal_developmental_patter0.12572018

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.33011391
2Abnormal respiratory motile cilium morphology (HP:0005938)9.08579012
3Abnormal respiratory epithelium morphology (HP:0012253)9.08579012
4Rhinitis (HP:0012384)7.48357888
5Chronic bronchitis (HP:0004469)7.46377316
6Abnormal ciliary motility (HP:0012262)7.22237355
7Infertility (HP:0000789)7.08942022
8Severe visual impairment (HP:0001141)6.89266568
9Nasal polyposis (HP:0100582)6.50739731
10Abnormality of the nasal mucosa (HP:0000433)5.35998854
11Male infertility (HP:0003251)4.93982185
12Muscle fiber inclusion bodies (HP:0100299)4.88859907
13Nemaline bodies (HP:0003798)4.82242065
14Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.78849912
15Bronchitis (HP:0012387)4.60746510
16Bronchiectasis (HP:0002110)4.40560339
17Nephronophthisis (HP:0000090)4.10220710
18Type 1 muscle fiber predominance (HP:0003803)4.03506078
19Attenuation of retinal blood vessels (HP:0007843)3.95698920
20Hyperkalemia (HP:0002153)3.95369971
21Bony spicule pigmentary retinopathy (HP:0007737)3.84659741
22Abnormal spermatogenesis (HP:0008669)3.80141660
23Muscle hypertrophy of the lower extremities (HP:0008968)3.58192655
24Hypoplastic ischia (HP:0003175)3.55108852
25Resting tremor (HP:0002322)3.52335249
26Abnormality of macular pigmentation (HP:0008002)3.48897108
27Recurrent otitis media (HP:0000403)3.28466409
28Abnormal rod and cone electroretinograms (HP:0008323)3.23960281
29Malignant hyperthermia (HP:0002047)3.19955821
30Ventricular tachycardia (HP:0004756)3.19370254
31Muscle fiber atrophy (HP:0100295)3.19314013
32Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.15720860
33Recurrent sinusitis (HP:0011108)3.14410240
34Abnormality of the ischium (HP:0003174)3.12016846
35Fetal akinesia sequence (HP:0001989)3.09683981
36Type 2 muscle fiber atrophy (HP:0003554)3.06931899
37Ulnar deviation of the wrist (HP:0003049)3.06853977
38Abnormality of the renal medulla (HP:0100957)3.03829306
39Distal arthrogryposis (HP:0005684)3.03664451
40Potter facies (HP:0002009)2.98241260
41Facial shape deformation (HP:0011334)2.98241260
42Popliteal pterygium (HP:0009756)2.97309418
43Calf muscle hypertrophy (HP:0008981)2.94745976
44Congenital sensorineural hearing impairment (HP:0008527)2.88211060
45Spastic paraparesis (HP:0002313)2.84207560
46Distal lower limb muscle weakness (HP:0009053)2.78658730
47Round ear (HP:0100830)2.76977645
48Weak cry (HP:0001612)2.76613350
49Cone-rod dystrophy (HP:0000548)2.76147762
50Abnormality of the left ventricular outflow tract (HP:0011103)2.72899821
51Subaortic stenosis (HP:0001682)2.72899821
52Recurrent bronchitis (HP:0002837)2.70325972
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.68615976
54Molar tooth sign on MRI (HP:0002419)2.67155922
55Abnormality of midbrain morphology (HP:0002418)2.67155922
56Tubular atrophy (HP:0000092)2.64997897
57Tubulointerstitial nephritis (HP:0001970)2.61512541
58Hyporeflexia of lower limbs (HP:0002600)2.60543263
59Enlarged epiphyses (HP:0010580)2.60132464
60Impulsivity (HP:0100710)2.57878761
61Aplasia/Hypoplasia of the earlobes (HP:0009906)2.51876011
62Abnormal gallbladder physiology (HP:0012438)2.51814261
63Cholecystitis (HP:0001082)2.51814261
64Muscle fiber splitting (HP:0003555)2.47200500
65Medial flaring of the eyebrow (HP:0010747)2.45967644
66Unilateral renal agenesis (HP:0000122)2.44217632
67Tubulointerstitial abnormality (HP:0001969)2.42637247
68Azoospermia (HP:0000027)2.42634912
69EMG: myopathic abnormalities (HP:0003458)2.38368470
70Chronic hepatic failure (HP:0100626)2.35241110
71Sudden death (HP:0001699)2.28468368
72Abnormality of potassium homeostasis (HP:0011042)2.27999289
73Dyschromatopsia (HP:0007641)2.26732362
74Hypoplastic heart (HP:0001961)2.20783729
75Abnormality of the aortic arch (HP:0012303)2.17528906
76Gowers sign (HP:0003391)2.14035136
77Gonadotropin excess (HP:0000837)2.12594925
78Postural instability (HP:0002172)2.11345230
79Tubulointerstitial fibrosis (HP:0005576)2.10763698
80Choroideremia (HP:0001139)2.10127383
81Centrally nucleated skeletal muscle fibers (HP:0003687)2.04447660
82Peripheral hypomyelination (HP:0007182)2.02887733
83Decreased central vision (HP:0007663)2.02106456
84Double outlet right ventricle (HP:0001719)2.01466899
85Congenital malformation of the right heart (HP:0011723)2.01466899
86Hypoalphalipoproteinemia (HP:0003233)2.01352703
87Bulbar palsy (HP:0001283)2.00912230
88Dynein arm defect of respiratory motile cilia (HP:0012255)13.1218539
89Absent/shortened dynein arms (HP:0200106)13.1218539
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1198675
91Amniotic constriction ring (HP:0009775)1.99635702
92Abnormality of placental membranes (HP:0011409)1.99635702
93Myotonia (HP:0002486)1.98845036
94Abnormality of the calf musculature (HP:0001430)1.97559508
95Progressive sensorineural hearing impairment (HP:0000408)1.96049479
96Truncal obesity (HP:0001956)1.95671316
97Calcaneovalgus deformity (HP:0001848)1.95347387
98Hypoplasia of the fovea (HP:0007750)1.95051053
99Aplasia/Hypoplasia of the fovea (HP:0008060)1.95051053
100Abnormality of the parathyroid morphology (HP:0011766)1.92344967
101Abnormality of the fovea (HP:0000493)1.91762285
102Myopathic facies (HP:0002058)1.91444522
103Aplasia/Hypoplasia of the macula (HP:0008059)1.90522808
104Atrial fibrillation (HP:0005110)1.89996461
105Polydipsia (HP:0001959)1.89453780
106Abnormal drinking behavior (HP:0030082)1.89453780
107Primary atrial arrhythmia (HP:0001692)1.87295452
108Generalized aminoaciduria (HP:0002909)1.86886915
109Spastic tetraparesis (HP:0001285)1.85425489
110Hemorrhage of the eye (HP:0011885)1.76570203
111Postaxial foot polydactyly (HP:0001830)1.74464321
112Stage 5 chronic kidney disease (HP:0003774)1.73444636
113Congenital hepatic fibrosis (HP:0002612)1.70408662
114Abnormality of renal excretion (HP:0011036)1.68983514
115Exercise-induced myalgia (HP:0003738)1.67791891
116Neurofibrillary tangles (HP:0002185)1.65562079
117Asymmetric septal hypertrophy (HP:0001670)1.63797289
118Hypoplasia of the capital femoral epiphysis (HP:0003090)1.63178192
119Decreased electroretinogram (ERG) amplitude (HP:0000654)1.62640198
120Abnormal biliary tract physiology (HP:0012439)1.62157369
121Bile duct proliferation (HP:0001408)1.62157369
122Heterotopia (HP:0002282)1.60230993
123Abnormality of the renal cortex (HP:0011035)1.57780408
124Aplasia/Hypoplasia of the lens (HP:0008063)1.56507067
125Bundle branch block (HP:0011710)1.53616001
126Myoglobinuria (HP:0002913)1.51472855
127Bell-shaped thorax (HP:0001591)1.51271690
128Oculomotor apraxia (HP:0000657)1.50326189
129Easy fatigability (HP:0003388)1.49352913
130Short ribs (HP:0000773)1.49307131
131Renal dysplasia (HP:0000110)1.46442415
132Abnormal urine output (HP:0012590)1.45016761
133Postaxial hand polydactyly (HP:0001162)1.40885091
134Abnormality of the neuromuscular junction (HP:0003398)1.39972242
135Fatigable weakness (HP:0003473)1.39972242
136Facial cleft (HP:0002006)1.38898246
137Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.35781330
138Exercise-induced muscle cramps (HP:0003710)1.35757591
139Abnormality of permanent molar morphology (HP:0011071)1.35203500
140Abnormality of the dental root (HP:0006486)1.35203500
141Taurodontia (HP:0000679)1.35203500
142Cerebellar dysplasia (HP:0007033)1.34716283
143Rhabdomyolysis (HP:0003201)1.34697018
144Abnormality of saccadic eye movements (HP:0000570)1.33935369
145Cerebral inclusion bodies (HP:0100314)1.33579797
146Chronic sinusitis (HP:0011109)1.32034185
147Cystic liver disease (HP:0006706)1.30525911
148Deformed sella turcica (HP:0002681)1.30404923
149Constricted visual fields (HP:0001133)1.30122252
150Fibular hypoplasia (HP:0003038)1.30072732
151Abnormality of dentin (HP:0010299)1.30049587
152Loss of speech (HP:0002371)1.30001479
153Sensory axonal neuropathy (HP:0003390)1.29020210
154Absent epiphyses (HP:0010577)1.27621780
155Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.27621780
156Abnormality of the dental pulp (HP:0006479)1.26690705
157Abnormality of molar (HP:0011077)1.24473910
158Abnormality of molar morphology (HP:0011070)1.24473910
159Hypercholesterolemia (HP:0003124)1.23553647
160Congenital primary aphakia (HP:0007707)1.23460123
161Gait imbalance (HP:0002141)1.23431158
162Pancreatic fibrosis (HP:0100732)1.22669348
163Generalized muscle weakness (HP:0003324)1.21947279
164Polyuria (HP:0000103)1.20948868
165Retinal dysplasia (HP:0007973)1.20551641
166Abnormality of the lower motor neuron (HP:0002366)1.18895371
167Abnormality of ocular smooth pursuit (HP:0000617)1.18101125
168Nephropathy (HP:0000112)1.17461670

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.91006944
2PDK47.91006944
3TESK16.90708330
4PRKD35.26294090
5PDK25.10906724
6ICK4.72070131
7DDR24.49387780
8MAP4K22.98501328
9PLK22.94182366
10INSRR2.90681432
11PIK3CG2.47718063
12BRD42.32294992
13PTK2B2.30328588
14WNK42.11259582
15STK382.08160309
16STK392.03736060
17PHKG21.84838384
18PHKG11.84838384
19NEK21.59431920
20DYRK1B1.58631826
21LATS21.45263234
22MAP3K91.44274490
23MST1R1.43818275
24UHMK11.43569947
25PNCK1.36107894
26PDK11.32496639
27KSR21.22124848
28MOS1.06956881
29CDK71.05012032
30DYRK30.92659020
31PDPK10.91149141
32DMPK0.86390483
33MARK10.84314321
34IRAK10.83486501
35TYRO30.82069780
36RIPK40.79617056
37ROCK10.78697147
38PRKAA20.78054196
39CAMK40.77993732
40MAPK150.77893598
41ARAF0.76185166
42SIK20.75250411
43MAP3K110.73125193
44EEF2K0.73071538
45WNK10.72921777
46CAMK10.72364596
47PASK0.70943917
48MAP3K20.70259536
49CDK120.67466559
50CCNB10.66920643
51PINK10.64867833
52STK30.58959140
53TESK20.58668494
54TTK0.58446039
55MUSK0.58244146
56RPS6KA20.58167310
57LMTK20.57355745
58CHEK20.56375135
59SGK4940.55979459
60SGK2230.55979459
61CAMKK20.55766549
62STK38L0.53257068
63IRAK20.53173848
64MAP2K60.50840376
65NTRK30.50473298
66MET0.49091085
67NME10.47659984
68MAPK100.44050175
69NTRK20.43479883
70SGK20.43284328
71MAP3K70.42868986
72CDK30.42865117
73MAP2K20.42845208
74MAP3K130.42485478
75PRKCG0.39020693
76PAK10.38259647
77MAP3K100.38101828
78MAP3K80.37940417
79SGK10.37527380
80SGK30.35912589
81CAMK2D0.35473881
82TNIK0.34948891
83CAMK2G0.34185472
84MAPK120.33179367
85BCKDK0.32945729
86LATS10.32794660
87CHEK10.31987976
88MAPK110.31652216
89MAPK10.31363488
90CAMK1G0.30920316
91MAPKAPK50.28483895
92BRSK20.26971277
93PAK20.26461958
94MARK20.26261406
95CAMKK10.25968777
96RPS6KL10.25384494
97RPS6KC10.25384494
98PRKACB0.23504973
99MAP2K10.23333005
100PAK40.23143224
101RPS6KA60.22916547
102ERBB30.22541814
103ATM0.21775308
104PRKCZ0.21303815
105MTOR0.21203484
106CAMK1D0.20538183
107AKT30.20294478
108PRKAA10.20062648
109ATR0.18464400
110ABL20.16929669
111PRKCQ0.16828318
112WEE10.16618449
113CDK150.16075890
114RPS6KB10.15587554
115PRKG20.14849477
116BRSK10.14733724
117CDK180.13362433
118NEK60.13157172
119CDK11A0.11934734
120RPS6KA10.10271065
121CSF1R0.08887476
122BRAF0.08660079
123CDK140.08354774
124PLK40.08342341
125STK100.07510694
126PLK10.07507046
127MARK30.07186877
128CSNK2A10.06355596
129STK110.05388405
130GSK3B0.05123424
131PRKCD0.05060510
132ZAP700.04716809
133CAMK2A0.04660460
134PRKACG0.03945961
135PKN10.03425024
136TRIB30.03338163
137PIM10.03305330
138PRKG10.03130506
139MAPK80.02440625
140OBSCN0.02356790
141PRKCA0.01136296
142CLK10.00995697
143PRKCB0.00991337
144TTN0.00604810
145CDK60.00587298
146MAP3K40.00502197
147MAP3K50.00298532
148CDK20.00252945
149PDGFRB0.00221323
150CSNK2A20.00174072
151CSNK1D-0.0363835
152PRKACA-0.0320853
153RPS6KA3-0.0320835
154MAP3K1-0.0224099
155CDC7-0.0211093
156PAK6-0.0186380
157EGFR-0.0184971
158AURKA-0.0019898
159CDK1-0.0007694

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.60832840
2Fatty acid biosynthesis_Homo sapiens_hsa000614.75551118
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.39575654
4Pyruvate metabolism_Homo sapiens_hsa006203.34561556
5Vitamin B6 metabolism_Homo sapiens_hsa007503.32649817
6Olfactory transduction_Homo sapiens_hsa047403.28654432
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.26879514
8Linoleic acid metabolism_Homo sapiens_hsa005913.18379080
9Butanoate metabolism_Homo sapiens_hsa006503.12531143
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.79875168
11Glucagon signaling pathway_Homo sapiens_hsa049222.59472733
12Propanoate metabolism_Homo sapiens_hsa006402.59206151
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.36901654
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.20757364
15Arginine and proline metabolism_Homo sapiens_hsa003302.18619100
16Basal transcription factors_Homo sapiens_hsa030222.15261543
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.06368872
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.97374951
19Glycerolipid metabolism_Homo sapiens_hsa005611.93876580
20Selenocompound metabolism_Homo sapiens_hsa004501.91380807
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.89657569
22PPAR signaling pathway_Homo sapiens_hsa033201.87205757
23Dilated cardiomyopathy_Homo sapiens_hsa054141.82408690
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.79767000
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.78058211
26Pentose phosphate pathway_Homo sapiens_hsa000301.72098445
27Fat digestion and absorption_Homo sapiens_hsa049751.68792456
28Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.65013947
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.64141770
30Fructose and mannose metabolism_Homo sapiens_hsa000511.57688548
31Amphetamine addiction_Homo sapiens_hsa050311.57534976
32Phenylalanine metabolism_Homo sapiens_hsa003601.55489502
33Oocyte meiosis_Homo sapiens_hsa041141.54837974
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52363807
35Fatty acid degradation_Homo sapiens_hsa000711.52275005
36Arginine biosynthesis_Homo sapiens_hsa002201.50245988
37Ether lipid metabolism_Homo sapiens_hsa005651.49084843
38Mineral absorption_Homo sapiens_hsa049781.49066181
39Fatty acid metabolism_Homo sapiens_hsa012121.49033249
40Cardiac muscle contraction_Homo sapiens_hsa042601.48939696
41Carbon metabolism_Homo sapiens_hsa012001.45376935
42Viral myocarditis_Homo sapiens_hsa054161.37648063
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.37227153
44Tyrosine metabolism_Homo sapiens_hsa003501.29112203
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.24719707
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23347972
47Circadian rhythm_Homo sapiens_hsa047101.23201359
48Dorso-ventral axis formation_Homo sapiens_hsa043201.18211319
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16910113
50Glutathione metabolism_Homo sapiens_hsa004801.10155495
51Renin secretion_Homo sapiens_hsa049241.08049313
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.06986207
53Oxytocin signaling pathway_Homo sapiens_hsa049211.05287377
54Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03039436
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02276151
56Allograft rejection_Homo sapiens_hsa053301.01243157
57Fanconi anemia pathway_Homo sapiens_hsa034601.00537617
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99825837
59Autoimmune thyroid disease_Homo sapiens_hsa053200.99475098
60Type I diabetes mellitus_Homo sapiens_hsa049400.97361524
61Type II diabetes mellitus_Homo sapiens_hsa049300.95633646
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95591160
63Collecting duct acid secretion_Homo sapiens_hsa049660.94817269
64Antigen processing and presentation_Homo sapiens_hsa046120.93831820
65Purine metabolism_Homo sapiens_hsa002300.92837352
66Tight junction_Homo sapiens_hsa045300.92823898
67Hedgehog signaling pathway_Homo sapiens_hsa043400.92317961
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.89892719
69Biosynthesis of amino acids_Homo sapiens_hsa012300.89512678
70Graft-versus-host disease_Homo sapiens_hsa053320.89510694
71Huntingtons disease_Homo sapiens_hsa050160.88436673
72Insulin secretion_Homo sapiens_hsa049110.88088465
73Systemic lupus erythematosus_Homo sapiens_hsa053220.87752772
74Arachidonic acid metabolism_Homo sapiens_hsa005900.85160661
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82673693
76Morphine addiction_Homo sapiens_hsa050320.82162445
77Phototransduction_Homo sapiens_hsa047440.81558349
78Chemical carcinogenesis_Homo sapiens_hsa052040.81138243
79mRNA surveillance pathway_Homo sapiens_hsa030150.78415042
80Long-term potentiation_Homo sapiens_hsa047200.78116689
81Renin-angiotensin system_Homo sapiens_hsa046140.76424974
82Bile secretion_Homo sapiens_hsa049760.75690775
83Thyroid hormone synthesis_Homo sapiens_hsa049180.75188146
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73162193
85Estrogen signaling pathway_Homo sapiens_hsa049150.72067118
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63906334
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63091208
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.60184271
89Pancreatic secretion_Homo sapiens_hsa049720.59892246
90MAPK signaling pathway_Homo sapiens_hsa040100.58461800
91RNA transport_Homo sapiens_hsa030130.58263763
92Nicotine addiction_Homo sapiens_hsa050330.57486244
93Glutamatergic synapse_Homo sapiens_hsa047240.56674763
94ECM-receptor interaction_Homo sapiens_hsa045120.56658564
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56386671
96Cholinergic synapse_Homo sapiens_hsa047250.55882023
97Insulin signaling pathway_Homo sapiens_hsa049100.55600776
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53870740
99Legionellosis_Homo sapiens_hsa051340.53024986
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52838412
101Salivary secretion_Homo sapiens_hsa049700.52372193
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.51881187
103Calcium signaling pathway_Homo sapiens_hsa040200.51585374
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51482263
105AMPK signaling pathway_Homo sapiens_hsa041520.50834486
106Melanogenesis_Homo sapiens_hsa049160.49496159
107Alcoholism_Homo sapiens_hsa050340.48020969
108Synaptic vesicle cycle_Homo sapiens_hsa047210.47630683
109Sulfur metabolism_Homo sapiens_hsa009200.47583774
110GABAergic synapse_Homo sapiens_hsa047270.46274795
111ABC transporters_Homo sapiens_hsa020100.45853316
112Endocytosis_Homo sapiens_hsa041440.45787214
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45276217
114Protein digestion and absorption_Homo sapiens_hsa049740.45032879
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44500090
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44092774
117Gastric acid secretion_Homo sapiens_hsa049710.43162968
118Focal adhesion_Homo sapiens_hsa045100.42883084
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.40967527
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40044957
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38265408
122Inositol phosphate metabolism_Homo sapiens_hsa005620.37526536
123Metabolic pathways_Homo sapiens_hsa011000.36676915
124VEGF signaling pathway_Homo sapiens_hsa043700.34827420
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33482267
126Serotonergic synapse_Homo sapiens_hsa047260.32762003
127cAMP signaling pathway_Homo sapiens_hsa040240.31567378
128Taste transduction_Homo sapiens_hsa047420.26832006
129Cocaine addiction_Homo sapiens_hsa050300.26729695
130Circadian entrainment_Homo sapiens_hsa047130.26605343
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20480683
132Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20108843
133Pyrimidine metabolism_Homo sapiens_hsa002400.17716235
134Salmonella infection_Homo sapiens_hsa051320.15457521
135HIF-1 signaling pathway_Homo sapiens_hsa040660.13204846
136Insulin resistance_Homo sapiens_hsa049310.11072838
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.10769447
138B cell receptor signaling pathway_Homo sapiens_hsa046620.10568199
139Viral carcinogenesis_Homo sapiens_hsa052030.10025432
140Wnt signaling pathway_Homo sapiens_hsa043100.08881017
141Basal cell carcinoma_Homo sapiens_hsa052170.05825883

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »