HINFP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor that interacts with methyl-CpG-binding protein-2 (MBD2), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.98244811
2negative regulation of cell killing (GO:0031342)5.78953888
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.78953888
4fucose catabolic process (GO:0019317)4.81554994
5L-fucose metabolic process (GO:0042354)4.81554994
6L-fucose catabolic process (GO:0042355)4.81554994
7nuclear pore complex assembly (GO:0051292)4.43036121
8nuclear pore organization (GO:0006999)4.39368995
9kynurenine metabolic process (GO:0070189)4.28868432
10purine nucleobase biosynthetic process (GO:0009113)4.26980417
11indolalkylamine metabolic process (GO:0006586)4.26287943
12tryptophan catabolic process (GO:0006569)4.20123800
13indole-containing compound catabolic process (GO:0042436)4.20123800
14indolalkylamine catabolic process (GO:0046218)4.20123800
15DNA deamination (GO:0045006)4.10367342
16regulation of spindle organization (GO:0090224)4.08398416
17mitotic metaphase plate congression (GO:0007080)3.93241403
18mitotic nuclear envelope disassembly (GO:0007077)3.90782931
19nucleobase biosynthetic process (GO:0046112)3.90747802
20negative regulation of telomere maintenance (GO:0032205)3.90312405
21tryptophan metabolic process (GO:0006568)3.84866264
22mitotic G1 DNA damage checkpoint (GO:0031571)3.81238257
23response to pheromone (GO:0019236)3.78607955
24piRNA metabolic process (GO:0034587)3.72577436
25DNA replication checkpoint (GO:0000076)3.72259208
26nuclear envelope disassembly (GO:0051081)3.69328990
27membrane disassembly (GO:0030397)3.69328990
28mitotic chromosome condensation (GO:0007076)3.63996809
29detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.57690830
30ribosome biogenesis (GO:0042254)3.53508151
31mitotic G1/S transition checkpoint (GO:0044819)3.51787381
32detection of light stimulus involved in sensory perception (GO:0050962)3.44351801
33detection of light stimulus involved in visual perception (GO:0050908)3.44351801
34protein localization to kinetochore (GO:0034501)3.41892582
35folic acid metabolic process (GO:0046655)3.41865601
36gamma-aminobutyric acid transport (GO:0015812)3.40856052
37sulfation (GO:0051923)3.39891296
38pore complex assembly (GO:0046931)3.37906480
39regulation of mitotic spindle organization (GO:0060236)3.28550426
40regulation of response to tumor cell (GO:0002834)3.28462210
41positive regulation of response to tumor cell (GO:0002836)3.28462210
42positive regulation of immune response to tumor cell (GO:0002839)3.28462210
43regulation of immune response to tumor cell (GO:0002837)3.28462210
44negative regulation of mast cell activation (GO:0033004)3.27194190
45formation of translation preinitiation complex (GO:0001731)3.24912534
46metaphase plate congression (GO:0051310)3.22764833
47DNA unwinding involved in DNA replication (GO:0006268)3.22407597
48indole-containing compound metabolic process (GO:0042430)3.19605539
49neural tube formation (GO:0001841)3.17772823
50DNA methylation involved in gamete generation (GO:0043046)3.17112443
51ribosome assembly (GO:0042255)3.14474282
52mitotic sister chromatid segregation (GO:0000070)3.12932575
53water-soluble vitamin biosynthetic process (GO:0042364)3.12449871
54respiratory chain complex IV assembly (GO:0008535)3.12041710
55mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.11960584
56mitochondrial respiratory chain complex I assembly (GO:0032981)3.11960584
57NADH dehydrogenase complex assembly (GO:0010257)3.11960584
58cellular ketone body metabolic process (GO:0046950)3.11209615
59G1 DNA damage checkpoint (GO:0044783)3.10798446
60regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.09057747
61* regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.06411420
62preassembly of GPI anchor in ER membrane (GO:0016254)3.01587480
63positive regulation of chromosome segregation (GO:0051984)3.00789720
64nuclear envelope organization (GO:0006998)3.00632328
65cellular response to interleukin-15 (GO:0071350)3.00092679
66cornea development in camera-type eye (GO:0061303)2.98736664
67regulation of response to interferon-gamma (GO:0060330)2.98555638
68sister chromatid segregation (GO:0000819)2.98040118
69DNA replication initiation (GO:0006270)2.96552675
70protein complex biogenesis (GO:0070271)2.96416912
71cellular biogenic amine catabolic process (GO:0042402)2.93570915
72amine catabolic process (GO:0009310)2.93570915
73regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.93502404
74reciprocal meiotic recombination (GO:0007131)2.93501476
75reciprocal DNA recombination (GO:0035825)2.93501476
76DNA replication-dependent nucleosome assembly (GO:0006335)2.91543572
77DNA replication-dependent nucleosome organization (GO:0034723)2.91543572
78protein localization to chromosome, centromeric region (GO:0071459)2.90508626
79regulation of hippo signaling (GO:0035330)2.90009678
80regulation of nuclear cell cycle DNA replication (GO:0033262)2.89630677
81DNA duplex unwinding (GO:0032508)2.88900969
82IMP biosynthetic process (GO:0006188)2.88292791
83histone-serine phosphorylation (GO:0035404)2.88186071
84regulation of translational termination (GO:0006449)2.87981308
85protein K6-linked ubiquitination (GO:0085020)2.87406536
86DNA geometric change (GO:0032392)2.86540154
87monoubiquitinated protein deubiquitination (GO:0035520)2.85384782
88negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.84232382
89male meiosis I (GO:0007141)2.82575706
90epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.82202979
91axoneme assembly (GO:0035082)2.81882913
92cytochrome complex assembly (GO:0017004)2.81320105
93protein polyglutamylation (GO:0018095)2.81203760
94regulation of telomere maintenance (GO:0032204)2.80987622
95kinetochore organization (GO:0051383)2.80856648
96rRNA catabolic process (GO:0016075)2.80693068
97ketone body metabolic process (GO:1902224)2.80685521
98regulation of translation in response to stress (GO:0043555)2.78439170
99protein K11-linked deubiquitination (GO:0035871)2.76975573
100regulation of RNA export from nucleus (GO:0046831)2.76601532
101negative regulation of translation, ncRNA-mediated (GO:0040033)2.76495704
102regulation of translation, ncRNA-mediated (GO:0045974)2.76495704
103negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.76495704
104replication fork processing (GO:0031297)2.74185386
105positive regulation of gamma-delta T cell activation (GO:0046645)2.74045826
106histone H2A acetylation (GO:0043968)2.73981319
107negative regulation of transcription regulatory region DNA binding (GO:2000678)2.73794958
108mitochondrial respiratory chain complex assembly (GO:0033108)2.73250863
109gene silencing by RNA (GO:0031047)2.72751601
110pre-miRNA processing (GO:0031054)2.72319980
111platelet dense granule organization (GO:0060155)2.72161979
112intestinal epithelial cell development (GO:0060576)2.71781554
113establishment of chromosome localization (GO:0051303)2.70518569
114maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.69997997
115regulation of action potential (GO:0098900)2.69929792
116oxidative demethylation (GO:0070989)2.69677008
117primary amino compound metabolic process (GO:1901160)2.68042298
118cellular response to ATP (GO:0071318)2.67944442
119neuronal action potential (GO:0019228)2.67485937
120regulation of gamma-delta T cell differentiation (GO:0045586)2.67026549
121reflex (GO:0060004)2.65606119
122spindle assembly involved in mitosis (GO:0090307)2.65513424
123kidney morphogenesis (GO:0060993)2.65478718
124histone mRNA catabolic process (GO:0071044)2.65245558
125NAD biosynthetic process (GO:0009435)2.64845229
126ribonucleoprotein complex biogenesis (GO:0022613)2.64805361
127DNA strand elongation involved in DNA replication (GO:0006271)2.64715195
128folic acid-containing compound biosynthetic process (GO:0009396)2.63425877
129male meiosis (GO:0007140)2.62543522
130behavioral response to ethanol (GO:0048149)2.62411828
131synapsis (GO:0007129)2.61559832
132response to interleukin-15 (GO:0070672)2.61442052
133regulation of posttranscriptional gene silencing (GO:0060147)2.59638485
134regulation of gene silencing by miRNA (GO:0060964)2.59638485
135regulation of gene silencing by RNA (GO:0060966)2.59638485
136recombinational repair (GO:0000725)2.59617675
137double-strand break repair via homologous recombination (GO:0000724)2.59018367
138mannosylation (GO:0097502)2.58652690
139negative regulation of translational initiation (GO:0045947)2.58352315
140response to UV-C (GO:0010225)2.57785093
141adaptation of signaling pathway (GO:0023058)2.57167705
142spindle checkpoint (GO:0031577)2.57144313
143ubiquinone biosynthetic process (GO:0006744)2.57050836
144regulation of chromosome segregation (GO:0051983)2.56402155
145fucosylation (GO:0036065)2.55988320
146kinetochore assembly (GO:0051382)2.55944931
147antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.54905123
148antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.54905123
149L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.54777182
150snRNA metabolic process (GO:0016073)2.53991713
151multicellular organism reproduction (GO:0032504)2.53780668
152transmission of nerve impulse (GO:0019226)2.53710995
153pseudouridine synthesis (GO:0001522)2.53291227
154mitotic spindle checkpoint (GO:0071174)2.52623253
155regulation of rhodopsin mediated signaling pathway (GO:0022400)2.52404205
156protein localization to cilium (GO:0061512)2.52142791
157nonmotile primary cilium assembly (GO:0035058)2.51703103
158DNA damage response, signal transduction resulting in transcription (GO:0042772)2.50991206
159positive regulation of mitotic sister chromatid separation (GO:1901970)2.50747718
160positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.50747718
161positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.50747718
162chromatin assembly or disassembly (GO:0006333)2.50569304
163serotonin metabolic process (GO:0042428)2.50127095
164negative regulation of synaptic transmission, GABAergic (GO:0032229)2.49802263
165photoreceptor cell maintenance (GO:0045494)2.49524459
166regulation of sister chromatid cohesion (GO:0007063)2.49295230
167DNA strand elongation (GO:0022616)2.49204419
168membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.48855492
169epithelial cilium movement (GO:0003351)2.48675846
170snRNA processing (GO:0016180)2.48628581
171positive regulation of T cell differentiation in thymus (GO:0033089)2.48602930
172rhodopsin mediated signaling pathway (GO:0016056)2.48265384
173auditory receptor cell stereocilium organization (GO:0060088)2.48146181
174photoreceptor cell development (GO:0042461)2.48061739
175regulation of centrosome cycle (GO:0046605)2.48000955
176regulation of type I interferon-mediated signaling pathway (GO:0060338)2.47888447
177meiotic chromosome segregation (GO:0045132)2.47685104
178negative regulation of histone methylation (GO:0031061)2.47305513
179DNA conformation change (GO:0071103)2.47135710
180mitotic spindle assembly checkpoint (GO:0007094)2.46022736
181RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.45888108
182negative regulation of chromosome segregation (GO:0051985)2.45628161
183positive regulation of protein import into nucleus, translocation (GO:0033160)2.44881879
184protein-cofactor linkage (GO:0018065)2.44259134
185spinal cord motor neuron differentiation (GO:0021522)2.44170197
186G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.44137912
187pyrimidine nucleobase catabolic process (GO:0006208)2.43457259
188negative regulation of cytosolic calcium ion concentration (GO:0051481)2.43378197
189anterograde synaptic vesicle transport (GO:0048490)2.42355444
190somatic diversification of immune receptors via somatic mutation (GO:0002566)2.42152733
191somatic hypermutation of immunoglobulin genes (GO:0016446)2.42152733
192synaptic transmission, cholinergic (GO:0007271)2.41260621
193retinal cone cell development (GO:0046549)2.41180758

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.93480699
2ZNF274_21170338_ChIP-Seq_K562_Hela4.45995613
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.19735274
4EZH2_22144423_ChIP-Seq_EOC_Human3.56677503
5VDR_22108803_ChIP-Seq_LS180_Human3.55597403
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.26961773
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14861031
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.09201215
9GBX2_23144817_ChIP-Seq_PC3_Human2.78831692
10MYC_22102868_ChIP-Seq_BL_Human2.78029157
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66828725
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.64234144
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.62288987
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58468910
15IGF1R_20145208_ChIP-Seq_DFB_Human2.40839099
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.40624623
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37200715
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13017300
19EWS_26573619_Chip-Seq_HEK293_Human2.10253935
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10062261
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08735561
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.03564615
23E2F1_21310950_ChIP-Seq_MCF-7_Human1.99189310
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.98898948
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97842904
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97009580
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.95686370
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.95379127
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94690559
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.93992394
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.93974019
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.93737095
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93361242
34CIITA_25753668_ChIP-Seq_RAJI_Human1.92978104
35FUS_26573619_Chip-Seq_HEK293_Human1.92850406
36VDR_23849224_ChIP-Seq_CD4+_Human1.89658156
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.89017626
38ER_23166858_ChIP-Seq_MCF-7_Human1.87685765
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.86757121
40P300_19829295_ChIP-Seq_ESCs_Human1.86470840
41XRN2_22483619_ChIP-Seq_HELA_Human1.85310745
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83413457
43TAF15_26573619_Chip-Seq_HEK293_Human1.82785114
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81604260
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80588447
46* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.80026381
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79052601
48IRF1_19129219_ChIP-ChIP_H3396_Human1.75044508
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.74145413
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72992131
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71412915
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.70635560
53AR_21909140_ChIP-Seq_LNCAP_Human1.64356835
54FOXP3_21729870_ChIP-Seq_TREG_Human1.64216210
55REST_21632747_ChIP-Seq_MESCs_Mouse1.63360442
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63311608
57KDM5A_27292631_Chip-Seq_BREAST_Human1.62036413
58BCAT_22108803_ChIP-Seq_LS180_Human1.61396794
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60781323
60TP53_22573176_ChIP-Seq_HFKS_Human1.60490242
61GABP_19822575_ChIP-Seq_HepG2_Human1.60348124
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58577022
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57711345
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57324499
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57307976
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56688578
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55559825
68VDR_21846776_ChIP-Seq_THP-1_Human1.55397407
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.54894175
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54395400
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54014692
72* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53025223
73IRF8_22096565_ChIP-ChIP_GC-B_Human1.52819088
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52067168
75STAT3_23295773_ChIP-Seq_U87_Human1.51739998
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50702867
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50575012
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48123221
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46869967
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44397468
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44397468
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44041851
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42844462
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.42683499
85TCF4_23295773_ChIP-Seq_U87_Human1.41753541
86* TFEB_21752829_ChIP-Seq_HELA_Human1.40663809
87STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.39270734
88IRF8_21731497_ChIP-ChIP_J774_Mouse1.38869310
89AR_25329375_ChIP-Seq_VCAP_Human1.36797537
90E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36443090
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36269853
92DCP1A_22483619_ChIP-Seq_HELA_Human1.36052868
93MYC_18940864_ChIP-ChIP_HL60_Human1.35616094
94MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35374223
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34946411
96SMAD4_21799915_ChIP-Seq_A2780_Human1.34941249
97CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33327362
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32817611
99CBP_20019798_ChIP-Seq_JUKART_Human1.32509293
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32509293
101AR_21572438_ChIP-Seq_LNCaP_Human1.32266849
102MAF_26560356_Chip-Seq_TH1_Human1.31073821
103ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30376230
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.29036126
105ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27733903
106GATA3_21878914_ChIP-Seq_MCF-7_Human1.27645925
107NANOG_19829295_ChIP-Seq_ESCs_Human1.27224261
108SOX2_19829295_ChIP-Seq_ESCs_Human1.27224261
109IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26616071
110FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26478580
111FOXA1_25329375_ChIP-Seq_VCAP_Human1.26478580
112ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25922049
113NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25685074
114MYB_26560356_Chip-Seq_TH1_Human1.25485910
115RNF2_27304074_Chip-Seq_NSC_Mouse1.25296719
116KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24380883
117MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23471671
118* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23278289
119SALL1_21062744_ChIP-ChIP_HESCs_Human1.23172119
120HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21599064
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21418472
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21258351
123TCF4_22108803_ChIP-Seq_LS180_Human1.21228970
124PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21111173
125SPI1_23547873_ChIP-Seq_NB4_Human1.19880953
126NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19782786
127NCOR_22424771_ChIP-Seq_293T_Human1.19713084
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19496263
129HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18894337
130UTX_26944678_Chip-Seq_JUKART_Human1.18816970
131ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18189411
132* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17504899
133THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17022965
134RUNX2_22187159_ChIP-Seq_PCA_Human1.16973139
135KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16754043
136HOXB7_26014856_ChIP-Seq_BT474_Human1.16573806
137MYB_26560356_Chip-Seq_TH2_Human1.16400546
138CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15916703
139SCL_19346495_ChIP-Seq_HPC-7_Human1.15653867
140PRDM14_20953172_ChIP-Seq_ESCs_Human1.14574965
141* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14194217
142KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13872718
143DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13871572
144FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13726989
145ERA_21632823_ChIP-Seq_H3396_Human1.12373674
146FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12218804
147FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.12033053
148* AR_20517297_ChIP-Seq_VCAP_Human1.11408930
149ELK1_19687146_ChIP-ChIP_HELA_Human1.10015129
150STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09862367
151SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09472575
152SMAD3_21741376_ChIP-Seq_EPCs_Human1.09105570
153TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09001540
154SMAD4_21741376_ChIP-Seq_EPCs_Human1.08976238
155* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08603383
156E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08035844
157TCF7_22412390_ChIP-Seq_EML_Mouse1.07863486
158SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07005288
159TTF2_22483619_ChIP-Seq_HELA_Human1.06968778
160STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06622409
161RUNX1_22412390_ChIP-Seq_EML_Mouse1.06127551
162DROSHA_22980978_ChIP-Seq_HELA_Human1.05545013
163NFE2_27457419_Chip-Seq_LIVER_Mouse1.05431765
164PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04221274
165TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03716255
166MAF_26560356_Chip-Seq_TH2_Human1.03066711
167MYC_19829295_ChIP-Seq_ESCs_Human1.03011631
168POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02671853
169YY1_21170310_ChIP-Seq_MESCs_Mouse1.02647573
170FLI1_21867929_ChIP-Seq_TH2_Mouse1.02351488
171* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00148224
172REST_18959480_ChIP-ChIP_MESCs_Mouse0.99917758
173EZH2_27294783_Chip-Seq_NPCs_Mouse0.97339366
174AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97111998
175FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96228148
176JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96196427
177KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95458636
178PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95440435
179* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94933795
180TAF2_19829295_ChIP-Seq_ESCs_Human0.94392129
181EZH2_27304074_Chip-Seq_ESCs_Mouse0.91901311
182* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91886165
183EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91553323
184OCT4_20526341_ChIP-Seq_ESCs_Human0.91482105
185NANOG_21062744_ChIP-ChIP_HESCs_Human0.90746092
186NANOG_20526341_ChIP-Seq_ESCs_Human0.89806146
187SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89220877
188POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89137206
189GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88512744
190CRX_20693478_ChIP-Seq_RETINA_Mouse0.88046065
191ELK3_25401928_ChIP-Seq_HUVEC_Human0.85037816
192NCOR1_26117541_ChIP-Seq_K562_Human0.84230065
193E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.83997232

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003693_abnormal_embryo_hatching4.25026938
2MP0003111_abnormal_nucleus_morphology3.59564562
3MP0003077_abnormal_cell_cycle3.44666412
4MP0010094_abnormal_chromosome_stability3.39885015
5MP0008057_abnormal_DNA_replication3.35771760
6MP0004957_abnormal_blastocyst_morpholog3.05497653
7MP0003646_muscle_fatigue2.61007323
8MP0002102_abnormal_ear_morphology2.58313752
9MP0009278_abnormal_bone_marrow2.51019881
10MP0001968_abnormal_touch/_nociception2.42917560
11MP0005551_abnormal_eye_electrophysiolog2.42246137
12MP0008058_abnormal_DNA_repair2.38668874
13MP0010307_abnormal_tumor_latency2.38256048
14MP0003195_calcinosis2.37113943
15MP0008007_abnormal_cellular_replicative2.33108686
16MP0010352_gastrointestinal_tract_polyps2.29180928
17MP0000569_abnormal_digit_pigmentation2.25549347
18MP0009333_abnormal_splenocyte_physiolog2.25121328
19MP0005397_hematopoietic_system_phenotyp2.13418055
20MP0001545_abnormal_hematopoietic_system2.13418055
21MP0008877_abnormal_DNA_methylation2.11350579
22MP0001730_embryonic_growth_arrest2.11224713
23MP0009745_abnormal_behavioral_response2.05497410
24MP0000350_abnormal_cell_proliferation2.04137177
25MP0002736_abnormal_nociception_after2.02886542
26MP0009046_muscle_twitch2.01144209
27MP0002396_abnormal_hematopoietic_system2.00406401
28MP0008872_abnormal_physiological_respon1.99383133
29MP0003763_abnormal_thymus_physiology1.97472027
30MP0002653_abnormal_ependyma_morphology1.96906272
31MP0004808_abnormal_hematopoietic_stem1.95910164
32MP0001986_abnormal_taste_sensitivity1.94631616
33MP0005076_abnormal_cell_differentiation1.88539549
34MP0002398_abnormal_bone_marrow1.86566394
35MP0003880_abnormal_central_pattern1.86044919
36MP0005646_abnormal_pituitary_gland1.84440694
37MP0005645_abnormal_hypothalamus_physiol1.83071296
38MP0009840_abnormal_foam_cell1.81691404
39MP0004043_abnormal_pH_regulation1.78299630
40MP0004142_abnormal_muscle_tone1.77851012
41MP0001501_abnormal_sleep_pattern1.74132311
42MP0002837_dystrophic_cardiac_calcinosis1.73316419
43MP0001800_abnormal_humoral_immune1.72709812
44MP0002638_abnormal_pupillary_reflex1.71532368
45MP0006276_abnormal_autonomic_nervous1.71292303
46MP0000689_abnormal_spleen_morphology1.69940658
47MP0005253_abnormal_eye_physiology1.68739802
48MP0002272_abnormal_nervous_system1.68079262
49MP0000427_abnormal_hair_cycle1.67749359
50MP0000703_abnormal_thymus_morphology1.66676214
51MP0008875_abnormal_xenobiotic_pharmacok1.66240668
52MP0004133_heterotaxia1.63949107
53MP0002735_abnormal_chemical_nociception1.63385301
54MP0001486_abnormal_startle_reflex1.63234026
55MP0001485_abnormal_pinna_reflex1.63035132
56MP0002722_abnormal_immune_system1.62778853
57MP0006072_abnormal_retinal_apoptosis1.58016652
58MP0003011_delayed_dark_adaptation1.55406808
59MP0000631_abnormal_neuroendocrine_gland1.55276566
60MP0002019_abnormal_tumor_incidence1.54231185
61MP0002876_abnormal_thyroid_physiology1.52896321
62MP0004264_abnormal_extraembryonic_tissu1.52523980
63MP0003705_abnormal_hypodermis_morpholog1.51205322
64MP0003656_abnormal_erythrocyte_physiolo1.49203671
65MP0002452_abnormal_antigen_presenting1.49142614
66MP0002064_seizures1.47718413
67MP0002160_abnormal_reproductive_system1.47054929
68MP0004147_increased_porphyrin_level1.45886789
69MP0003123_paternal_imprinting1.45591415
70MP0004885_abnormal_endolymph1.45067163
71MP0000372_irregular_coat_pigmentation1.44602619
72MP0000716_abnormal_immune_system1.44406770
73MP0005423_abnormal_somatic_nervous1.44094156
74* MP0005380_embryogenesis_phenotype1.43724659
75* MP0001672_abnormal_embryogenesis/_devel1.43724659
76MP0009785_altered_susceptibility_to1.43280877
77MP0004145_abnormal_muscle_electrophysio1.42977152
78MP0001819_abnormal_immune_cell1.41156526
79MP0002938_white_spotting1.40972518
80MP0002420_abnormal_adaptive_immunity1.40282654
81MP0002572_abnormal_emotion/affect_behav1.39472141
82MP0002723_abnormal_immune_serum1.38703467
83MP0002429_abnormal_blood_cell1.38235576
84MP0005671_abnormal_response_to1.38095065
85* MP0002080_prenatal_lethality1.37296892
86MP0003136_yellow_coat_color1.37291314
87MP0001697_abnormal_embryo_size1.36946215
88MP0003984_embryonic_growth_retardation1.35846266
89MP0002086_abnormal_extraembryonic_tissu1.34778442
90MP0002557_abnormal_social/conspecific_i1.34662522
91MP0002088_abnormal_embryonic_growth/wei1.33894115
92MP0000490_abnormal_crypts_of1.32304337
93MP0005174_abnormal_tail_pigmentation1.31980588
94MP0005389_reproductive_system_phenotype1.31845819
95MP0001970_abnormal_pain_threshold1.30414626
96MP0002733_abnormal_thermal_nociception1.29668972
97MP0000313_abnormal_cell_death1.28913956
98MP0004742_abnormal_vestibular_system1.23892413
99MP0001835_abnormal_antigen_presentation1.23675995
100MP0003635_abnormal_synaptic_transmissio1.22556211
101MP0000685_abnormal_immune_system1.21152151
102MP0003718_maternal_effect1.20623791
103MP0008932_abnormal_embryonic_tissue1.18783038
104MP0010155_abnormal_intestine_physiology1.16604340
105MP0002067_abnormal_sensory_capabilities1.14969661
106MP0005386_behavior/neurological_phenoty1.14086630
107MP0004924_abnormal_behavior1.14086630
108MP0002063_abnormal_learning/memory/cond1.12509399
109MP0004197_abnormal_fetal_growth/weight/1.12316908
110MP0004947_skin_inflammation1.11717163
111MP0002928_abnormal_bile_duct1.11552014
112MP0005621_abnormal_cell_physiology1.10641124
113MP0005000_abnormal_immune_tolerance1.09188730
114MP0008995_early_reproductive_senescence1.08992258
115MP0003448_altered_tumor_morphology1.08626622
116MP0002405_respiratory_system_inflammati1.08483585
117MP0002084_abnormal_developmental_patter1.08199526
118MP0001915_intracranial_hemorrhage1.08155197
119MP0002085_abnormal_embryonic_tissue1.08078644
120MP0000383_abnormal_hair_follicle1.08059957
121MP0002210_abnormal_sex_determination1.07370714
122MP0003566_abnormal_cell_adhesion1.06044373
123MP0001790_abnormal_immune_system1.04360379
124MP0005387_immune_system_phenotype1.04360379
125MP0002095_abnormal_skin_pigmentation1.04027714
126MP0001984_abnormal_olfaction1.02803270
127MP0002138_abnormal_hepatobiliary_system1.01523352
128MP0005195_abnormal_posterior_eye1.01258568
129MP0003786_premature_aging1.01071067
130MP0003698_abnormal_male_reproductive1.01008947
131MP0003787_abnormal_imprinting1.00412734
132MP0010386_abnormal_urinary_bladder1.00178367
133MP0000778_abnormal_nervous_system0.99991385
134MP0000858_altered_metastatic_potential0.99571583
135MP0005025_abnormal_response_to0.99112151
136MP0005075_abnormal_melanosome_morpholog0.98320872
137MP0000230_abnormal_systemic_arterial0.98080811
138MP0003436_decreased_susceptibility_to0.96385098
139MP0002752_abnormal_somatic_nervous0.95858497
140MP0003303_peritoneal_inflammation0.94787113
141MP0002734_abnormal_mechanical_nocicepti0.93693448
142MP0001145_abnormal_male_reproductive0.93684076
143MP0002163_abnormal_gland_morphology0.93623464
144MP0003567_abnormal_fetal_cardiomyocyte0.93095155
145MP0005410_abnormal_fertilization0.92113653
146MP0001963_abnormal_hearing_physiology0.92071382
147MP0002184_abnormal_innervation0.91666147
148MP0001529_abnormal_vocalization0.91645338
149MP0005384_cellular_phenotype0.91411214
150MP0008961_abnormal_basal_metabolism0.91411117
151MP0005464_abnormal_platelet_physiology0.90858577
152MP0003119_abnormal_digestive_system0.90388587
153MP0000026_abnormal_inner_ear0.88520685
154MP0000371_diluted_coat_color0.88305452
155MP0000598_abnormal_liver_morphology0.87493877
156MP0003300_gastrointestinal_ulcer0.87135394
157MP0005448_abnormal_energy_balance0.86576538
158MP0006292_abnormal_olfactory_placode0.86096752
159MP0003221_abnormal_cardiomyocyte_apopto0.85900480
160MP0002229_neurodegeneration0.85247798
161MP0006054_spinal_hemorrhage0.85135435
162MP0005084_abnormal_gallbladder_morpholo0.85018215
163MP0000538_abnormal_urinary_bladder0.83990810
164MP0002419_abnormal_innate_immunity0.83903475
165MP0003121_genomic_imprinting0.83484481
166MP0001853_heart_inflammation0.82986509
167MP0001845_abnormal_inflammatory_respons0.82911229
168MP0005023_abnormal_wound_healing0.82678743
169MP0000015_abnormal_ear_pigmentation0.81844792
170MP0008789_abnormal_olfactory_epithelium0.80639024
171MP0003890_abnormal_embryonic-extraembry0.79792396
172MP0005167_abnormal_blood-brain_barrier0.79683920
173MP0003866_abnormal_defecation0.79130673
174MP0001905_abnormal_dopamine_level0.78095233
175MP0000465_gastrointestinal_hemorrhage0.77969113
176MP0003878_abnormal_ear_physiology0.77671490
177MP0005377_hearing/vestibular/ear_phenot0.77671490
178MP0001919_abnormal_reproductive_system0.77630179
179MP0001324_abnormal_eye_pigmentation0.76340524
180MP0001502_abnormal_circadian_rhythm0.75923161
181MP0003137_abnormal_impulse_conducting0.75888654
182MP0005085_abnormal_gallbladder_physiolo0.75888447
183MP0000653_abnormal_sex_gland0.75775887
184MP0002882_abnormal_neuron_morphology0.75226130
185MP0001929_abnormal_gametogenesis0.74495566
186MP0005310_abnormal_salivary_gland0.74486660
187MP0003091_abnormal_cell_migration0.69370327
188MP0006082_CNS_inflammation0.69247049
189MP0002075_abnormal_coat/hair_pigmentati0.67181467
190MP0000733_abnormal_muscle_development0.66821959

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.56469200
2Molar tooth sign on MRI (HP:0002419)4.15875173
3Abnormality of midbrain morphology (HP:0002418)4.15875173
4Birth length less than 3rd percentile (HP:0003561)4.09750921
5T lymphocytopenia (HP:0005403)4.06887445
6Pancreatic fibrosis (HP:0100732)3.98601422
7Congenital stationary night blindness (HP:0007642)3.94506298
8Abnormality of T cell number (HP:0011839)3.92164260
9True hermaphroditism (HP:0010459)3.80989285
10Combined immunodeficiency (HP:0005387)3.64401570
11Severe combined immunodeficiency (HP:0004430)3.58657443
12Thyroiditis (HP:0100646)3.45991085
13Nephronophthisis (HP:0000090)3.43771267
14Autoimmune thrombocytopenia (HP:0001973)3.33246482
15Abnormality of the fingertips (HP:0001211)3.29295863
16Hyperventilation (HP:0002883)3.26272387
17Type II lissencephaly (HP:0007260)3.25646104
18Attenuation of retinal blood vessels (HP:0007843)3.24235220
19Abnormality of the renal cortex (HP:0011035)3.16561877
20Chronic hepatic failure (HP:0100626)3.08204658
21Pendular nystagmus (HP:0012043)3.04630503
22Abolished electroretinogram (ERG) (HP:0000550)3.01279222
23Abnormality of the renal medulla (HP:0100957)3.00304680
24Abnormality of the anterior horn cell (HP:0006802)2.99143415
25Degeneration of anterior horn cells (HP:0002398)2.99143415
26Breast hypoplasia (HP:0003187)2.96108090
27Cystic liver disease (HP:0006706)2.95881611
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.92680654
29Abnormality of alanine metabolism (HP:0010916)2.92680654
30Hyperalaninemia (HP:0003348)2.92680654
31Entropion (HP:0000621)2.82370893
32Abnormality of T cells (HP:0002843)2.76999050
33Patellar aplasia (HP:0006443)2.76404320
34Tubular atrophy (HP:0000092)2.71372657
35Facial hemangioma (HP:0000329)2.70273762
36Medial flaring of the eyebrow (HP:0010747)2.70019403
37Inability to walk (HP:0002540)2.68924068
38Pustule (HP:0200039)2.67697745
39Recurrent viral infections (HP:0004429)2.66614252
40Spinal muscular atrophy (HP:0007269)2.66604233
41Abnormality of eosinophils (HP:0001879)2.63816796
42Lissencephaly (HP:0001339)2.63529040
43Abnormal drinking behavior (HP:0030082)2.63474075
44Polydipsia (HP:0001959)2.63474075
45Genetic anticipation (HP:0003743)2.61199767
46Aplasia/Hypoplasia of the patella (HP:0006498)2.59148513
47Stomach cancer (HP:0012126)2.59008484
48Protruding tongue (HP:0010808)2.58544529
49Overlapping toe (HP:0001845)2.58159870
50Chromsome breakage (HP:0040012)2.55328687
51Absent rod-and cone-mediated responses on ERG (HP:0007688)2.52424217
52Gaze-evoked nystagmus (HP:0000640)2.47639453
53Sclerocornea (HP:0000647)2.47286469
54Broad-based gait (HP:0002136)2.46842798
55Abnormal rod and cone electroretinograms (HP:0008323)2.45668812
56Pelvic girdle muscle weakness (HP:0003749)2.45522687
57Clumsiness (HP:0002312)2.44543853
58Abnormality of chromosome stability (HP:0003220)2.44336493
59Basal cell carcinoma (HP:0002671)2.42317663
60Lymphoma (HP:0002665)2.42004112
61Leukocytosis (HP:0001974)2.41693580
62Chromosomal breakage induced by crosslinking agents (HP:0003221)2.41361189
63Decreased central vision (HP:0007663)2.40223654
64Progressive inability to walk (HP:0002505)2.39755226
65Myelodysplasia (HP:0002863)2.38909381
66Amaurosis fugax (HP:0100576)2.37204282
67Cerebellar dysplasia (HP:0007033)2.36417657
68Progressive cerebellar ataxia (HP:0002073)2.36276448
69Decreased circulating renin level (HP:0003351)2.36229734
70Increased IgM level (HP:0003496)2.35933809
71Anencephaly (HP:0002323)2.33571734
72Prominent nose (HP:0000448)2.31927213
73Ectopic kidney (HP:0000086)2.31351685
74Shoulder girdle muscle weakness (HP:0003547)2.30183917
75Increased corneal curvature (HP:0100692)2.29778508
76Keratoconus (HP:0000563)2.29778508
77IgA deficiency (HP:0002720)2.29147941
78Abnormal biliary tract physiology (HP:0012439)2.28791356
79Bile duct proliferation (HP:0001408)2.28791356
80Thrombocytosis (HP:0001894)2.26281421
81Bony spicule pigmentary retinopathy (HP:0007737)2.24809437
82Global brain atrophy (HP:0002283)2.23902466
83Concave nail (HP:0001598)2.23286138
84Cutaneous melanoma (HP:0012056)2.22513314
85Meckel diverticulum (HP:0002245)2.21979921
86Aplasia/Hypoplasia of the uvula (HP:0010293)2.21797489
87IgG deficiency (HP:0004315)2.17444515
88Decreased electroretinogram (ERG) amplitude (HP:0000654)2.16861925
89Osteolytic defects of the phalanges of the hand (HP:0009771)2.16762550
90Osteolytic defects of the hand bones (HP:0009699)2.16762550
91Premature graying of hair (HP:0002216)2.15319302
92Poikiloderma (HP:0001029)2.15240943
93Abnormality of cells of the lymphoid lineage (HP:0012140)2.14928195
94Carpal bone hypoplasia (HP:0001498)2.14834436
95High pitched voice (HP:0001620)2.14356377
96Lymphopenia (HP:0001888)2.12767881
97Febrile seizures (HP:0002373)2.12719114
98Gait imbalance (HP:0002141)2.12336754
99Squamous cell carcinoma (HP:0002860)2.11752458
100Dynein arm defect of respiratory motile cilia (HP:0012255)2.11686973
101Absent/shortened dynein arms (HP:0200106)2.11686973
102Congenital hepatic fibrosis (HP:0002612)2.11512998
103Chorioretinal atrophy (HP:0000533)2.10618791
104Retinal dysplasia (HP:0007973)2.09560569
105Absent speech (HP:0001344)2.08676936
106Furrowed tongue (HP:0000221)2.07191562
107Aplasia/Hypoplasia of the tongue (HP:0010295)2.06725387
108Recurrent fungal infections (HP:0002841)2.06632632
109Small epiphyses (HP:0010585)2.05631733
110Polyuria (HP:0000103)2.05071745
111Abnormality of the ileum (HP:0001549)2.04500568
112Atrophy/Degeneration involving motor neurons (HP:0007373)2.04457817
113Abnormality of the preputium (HP:0100587)2.03445787
114Multiple enchondromatosis (HP:0005701)2.03273982
115Bone marrow hypocellularity (HP:0005528)2.02946283
116Cafe-au-lait spot (HP:0000957)2.00874890
117Congenital primary aphakia (HP:0007707)2.00819734
118Prominent metopic ridge (HP:0005487)2.00204448
119IgM deficiency (HP:0002850)1.98619240
120Aplasia/Hypoplasia of the tibia (HP:0005772)1.98170037
121Nephrogenic diabetes insipidus (HP:0009806)1.97613257
122Renal cortical cysts (HP:0000803)1.97289961
123Abnormality of the carotid arteries (HP:0005344)1.97170884
124Periodontitis (HP:0000704)1.96385838
125Intestinal atresia (HP:0011100)1.95736024
126Abnormality of the pons (HP:0007361)1.95572900
127Heterotopia (HP:0002282)1.95515798
128Large for gestational age (HP:0001520)1.93957311
129Cheilitis (HP:0100825)1.93777474
130Pachygyria (HP:0001302)1.93443408
131Severe muscular hypotonia (HP:0006829)1.92225992
132Absent thumb (HP:0009777)1.91529435
133Abnormality of the vasculature of the conjunctiva (HP:0008054)1.89433198
134Male pseudohermaphroditism (HP:0000037)1.89320369
135Flat capital femoral epiphysis (HP:0003370)1.88592847
136Increased CSF lactate (HP:0002490)1.88435181
137Impulsivity (HP:0100710)1.88165850
138Ependymoma (HP:0002888)1.87711378
139Abnormality of DNA repair (HP:0003254)1.87650638
140Sparse lateral eyebrow (HP:0005338)1.87118735
141Cellular immunodeficiency (HP:0005374)1.85902415
142Aplastic anemia (HP:0001915)1.85773373
143Small hand (HP:0200055)1.85530304
144Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.85279061
145Short 4th metacarpal (HP:0010044)1.85279061
146Abnormality of the metopic suture (HP:0005556)1.85134851
147Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84273416
148Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84047801
149Fair hair (HP:0002286)1.83127741
150Acute myeloid leukemia (HP:0004808)1.82755238
151Conjunctival telangiectasia (HP:0000524)1.81131456
152Congenital, generalized hypertrichosis (HP:0004540)1.80859110
153Small intestinal stenosis (HP:0012848)1.79297728
154Duodenal stenosis (HP:0100867)1.79297728
155Chronic otitis media (HP:0000389)1.79225489
156Recurrent bronchitis (HP:0002837)1.79081019
157Focal seizures (HP:0007359)1.77341819
158Abnormality of the musculature of the pelvis (HP:0001469)1.77257400
159Abnormality of the hip-girdle musculature (HP:0001445)1.77257400
160Neoplasm of the oral cavity (HP:0100649)1.77178438
161Urethral obstruction (HP:0000796)1.77123643
162Colon cancer (HP:0003003)1.77074407
163Slender long bone (HP:0003100)1.76704738
164Methylmalonic acidemia (HP:0002912)1.76277812
165Abnormality of the labia minora (HP:0012880)1.76229654
166Hypoplasia of the fovea (HP:0007750)1.74836192
167Aplasia/Hypoplasia of the fovea (HP:0008060)1.74836192
168Delayed puberty (HP:0000823)1.74475854
169Dandy-Walker malformation (HP:0001305)1.73945825
170Mitochondrial inheritance (HP:0001427)1.73860031
171Genital tract atresia (HP:0001827)1.73733115
172Postaxial foot polydactyly (HP:0001830)1.73562260
173Deep philtrum (HP:0002002)1.72946806
174Long eyelashes (HP:0000527)1.72868719
175Vaginal atresia (HP:0000148)1.72664735
176Methylmalonic aciduria (HP:0012120)1.72550850
177Hemiparesis (HP:0001269)1.72546596
178Teleangiectasia of the skin (HP:0100585)1.72243983
179Rough bone trabeculation (HP:0100670)1.71842308
180Ketosis (HP:0001946)1.71464419
1813-Methylglutaconic aciduria (HP:0003535)1.70465186
182Deviation of the thumb (HP:0009603)1.69480944
183Cellulitis (HP:0100658)1.67638147
184Preaxial hand polydactyly (HP:0001177)1.67503796
185Optic nerve hypoplasia (HP:0000609)1.66324791
186Hypoplasia of the pons (HP:0012110)1.66245522
187Joint swelling (HP:0001386)1.65952906
188Oral leukoplakia (HP:0002745)1.65782731
189Proximal placement of thumb (HP:0009623)1.65582655
190Neoplasm of the pancreas (HP:0002894)1.65203113
191Tachypnea (HP:0002789)1.65130192
192Dialeptic seizures (HP:0011146)1.64749747
193Partial agenesis of the corpus callosum (HP:0001338)1.64729313
194Agitation (HP:0000713)1.64696979
195Poor coordination (HP:0002370)1.64436350

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.24668831
2BUB13.85224379
3BMPR1B3.77824182
4ADRBK23.15291463
5NEK23.10123829
6TLK12.99321142
7EEF2K2.83407745
8MAP4K12.76634192
9TRIB32.59342914
10MAP4K22.53491788
11GRK12.37759659
12WNK42.35332780
13EPHA32.31894383
14CDC72.27220564
15WNK32.27156589
16EIF2AK12.26901808
17INSRR2.25853425
18PLK42.24070377
19NUAK12.20092648
20PINK12.18344069
21MAPK132.07616672
22CDK121.98868335
23WEE11.93209903
24ACVR1B1.82242194
25MAP3K101.81715226
26SRPK11.75049710
27TSSK61.72164905
28STK101.72004555
29CASK1.69358048
30OXSR11.68436703
31IRAK31.65603941
32DAPK21.63134642
33JAK31.57073198
34FGFR41.54050225
35TTK1.48790094
36MAP3K41.48425144
37NME21.48340415
38PKN21.48093781
39STK41.47413915
40STK31.46439643
41TXK1.40197616
42CDK41.37997334
43PASK1.37943123
44BRSK21.36797739
45STK161.33853871
46STK391.32609663
47JAK11.32448897
48NLK1.32277270
49PLK11.31566111
50TAOK31.30986083
51RPS6KA41.28979519
52AURKB1.27467538
53ATR1.26196589
54MKNK21.26081579
55ADRBK11.25910649
56BRSK11.24359165
57IKBKB1.23666489
58MARK11.22257313
59CHEK11.21305465
60TYK21.17753776
61CHUK1.14491238
62ALK1.14122657
63ZAP701.11684950
64PIM11.11133585
65TGFBR11.10200039
66ERN11.09238097
67DYRK21.07948060
68CDK71.07763117
69MAP3K141.06597488
70SIK21.05886543
71MUSK1.04962085
72EIF2AK31.03361315
73NTRK31.02812217
74CDK61.01616340
75IKBKE0.97003694
76GRK60.95763273
77PRKCG0.95520295
78STK240.95089211
79TRIM280.94285652
80CHEK20.93569511
81TESK20.93440783
82MAP3K80.92172286
83PAK30.90626015
84MST40.90565180
85ITK0.89131434
86MAP2K70.88703862
87FLT30.88220751
88RPS6KB20.86206475
89BRD40.84847908
90PLK30.83897039
91MTOR0.79860905
92STK110.79664629
93BCKDK0.79583520
94TNIK0.79313741
95CDK20.79081399
96PIK3CA0.78991104
97MKNK10.78347024
98LATS10.75437348
99VRK20.75247467
100MAPKAPK50.75188013
101STK38L0.74291044
102ATM0.74138797
103LATS20.73339234
104MAPKAPK30.72779772
105PRKCE0.72510599
106MAP2K60.72471890
107CAMKK20.69103143
108TNK20.68959943
109MAPK110.67287069
110PTK2B0.67188454
111PKN10.65839936
112CSF1R0.65105573
113DYRK30.64179867
114LCK0.63636475
115PHKG10.63585130
116PHKG20.63585130
117NEK10.63313252
118SYK0.62658823
119PRKCQ0.62227421
120VRK10.62203012
121ZAK0.61527216
122NME10.60418640
123TEC0.58721704
124NEK60.58118764
125MAPK150.57117217
126CAMK10.56579069
127PRKCI0.55809558
128RPS6KA50.55574402
129HCK0.55312175
130BTK0.55014972
131MELK0.55009683
132KIT0.54134633
133FGFR20.53251158
134CAMK1D0.51796883
135NTRK20.51185010
136TBK10.50545471
137PDGFRB0.50152399
138FGFR30.50118136
139EPHA40.49769374
140CLK10.49278781
141EPHA20.48531958
142PDGFRA0.48451958
143TYRO30.48432717
144CDK10.47801480
145IRAK10.46269015
146TAOK10.45726404
147CAMK2A0.45673246
148PRKCZ0.45562286
149PLK20.44954674
150MAP2K30.43840275
151CSK0.43104368
152PNCK0.41955577
153TIE10.41894695
154PRKAA10.41323053
155PRKAA20.41083377
156PRKACA0.41082824
157CSNK1G20.40698398
158PAK20.39903244
159RPS6KA60.39073430
160CAMK1G0.38769540
161CSNK1G10.38080506
162EIF2AK20.37663116
163CCNB10.37543720
164AKT30.36436983
165CSNK1A1L0.36421029
166NEK90.36280948
167CSNK1A10.36257387
168CAMK40.36156220
169MAP3K70.36022757
170MAPK70.35748421
171PDK20.34610437
172LRRK20.33790433
173PRKCA0.33762427
174MAP2K10.33738965
175MARK30.33638849
176SGK20.33103781
177CSNK1D0.31807883

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.66421722
2DNA replication_Homo sapiens_hsa030302.99467916
3Phototransduction_Homo sapiens_hsa047442.88443463
4RNA transport_Homo sapiens_hsa030132.77617354
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.58571527
6Linoleic acid metabolism_Homo sapiens_hsa005912.56679370
7Primary immunodeficiency_Homo sapiens_hsa053402.50160944
8Cell cycle_Homo sapiens_hsa041102.48109896
9Mismatch repair_Homo sapiens_hsa034302.46484660
10Nicotine addiction_Homo sapiens_hsa050332.43784483
11Vitamin B6 metabolism_Homo sapiens_hsa007502.41423702
12Spliceosome_Homo sapiens_hsa030402.39321454
13Nitrogen metabolism_Homo sapiens_hsa009102.36557412
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.35925893
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.30973487
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.28762832
17Base excision repair_Homo sapiens_hsa034102.26307205
18RNA polymerase_Homo sapiens_hsa030202.18036848
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.15604840
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.12592529
21Butanoate metabolism_Homo sapiens_hsa006502.00554289
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.00021640
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.99693592
24p53 signaling pathway_Homo sapiens_hsa041151.95769981
25Nucleotide excision repair_Homo sapiens_hsa034201.93682337
26Tryptophan metabolism_Homo sapiens_hsa003801.89563799
27Caffeine metabolism_Homo sapiens_hsa002321.88101568
28Homologous recombination_Homo sapiens_hsa034401.87909040
29Ether lipid metabolism_Homo sapiens_hsa005651.87088951
30One carbon pool by folate_Homo sapiens_hsa006701.80775802
31Fanconi anemia pathway_Homo sapiens_hsa034601.80427312
32Oxidative phosphorylation_Homo sapiens_hsa001901.76600400
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.75934036
34RNA degradation_Homo sapiens_hsa030181.61133309
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60220894
36Herpes simplex infection_Homo sapiens_hsa051681.60049486
37mRNA surveillance pathway_Homo sapiens_hsa030151.58343931
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56945753
39Basal transcription factors_Homo sapiens_hsa030221.52178852
40Antigen processing and presentation_Homo sapiens_hsa046121.51932843
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51163299
42Taste transduction_Homo sapiens_hsa047421.47673437
43Morphine addiction_Homo sapiens_hsa050321.44840821
44Measles_Homo sapiens_hsa051621.42369238
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39266312
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.35272730
47Olfactory transduction_Homo sapiens_hsa047401.35085827
48Parkinsons disease_Homo sapiens_hsa050121.34119468
49ABC transporters_Homo sapiens_hsa020101.31489323
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.29487934
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29253292
52Epstein-Barr virus infection_Homo sapiens_hsa051691.26322188
53Viral carcinogenesis_Homo sapiens_hsa052031.24495173
54Pyrimidine metabolism_Homo sapiens_hsa002401.20527828
55Circadian entrainment_Homo sapiens_hsa047131.17377036
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16669015
57Folate biosynthesis_Homo sapiens_hsa007901.16091051
58Chronic myeloid leukemia_Homo sapiens_hsa052201.15665719
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.15245997
60Non-homologous end-joining_Homo sapiens_hsa034501.13833844
61Systemic lupus erythematosus_Homo sapiens_hsa053221.13323583
62B cell receptor signaling pathway_Homo sapiens_hsa046621.12359129
63Glutamatergic synapse_Homo sapiens_hsa047241.11711457
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10809526
65Steroid hormone biosynthesis_Homo sapiens_hsa001401.08239396
66Small cell lung cancer_Homo sapiens_hsa052221.06594565
67Apoptosis_Homo sapiens_hsa042101.06206255
68Propanoate metabolism_Homo sapiens_hsa006401.06147693
69Legionellosis_Homo sapiens_hsa051341.04184045
70Ribosome_Homo sapiens_hsa030101.03926686
71Asthma_Homo sapiens_hsa053101.02588038
72Serotonergic synapse_Homo sapiens_hsa047261.02323793
73Insulin secretion_Homo sapiens_hsa049111.01433209
74Proteasome_Homo sapiens_hsa030501.01128506
75Acute myeloid leukemia_Homo sapiens_hsa052211.00173366
76Influenza A_Homo sapiens_hsa051640.99933105
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99931650
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99227872
79GABAergic synapse_Homo sapiens_hsa047270.97849863
80Chemical carcinogenesis_Homo sapiens_hsa052040.97832381
81Selenocompound metabolism_Homo sapiens_hsa004500.96687876
82Peroxisome_Homo sapiens_hsa041460.96329650
83MicroRNAs in cancer_Homo sapiens_hsa052060.95038869
84Hepatitis B_Homo sapiens_hsa051610.94469806
85HTLV-I infection_Homo sapiens_hsa051660.93397762
86Huntingtons disease_Homo sapiens_hsa050160.92451840
87Leishmaniasis_Homo sapiens_hsa051400.91918522
88Glycerolipid metabolism_Homo sapiens_hsa005610.90666807
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90479752
90Lysine degradation_Homo sapiens_hsa003100.89696361
91T cell receptor signaling pathway_Homo sapiens_hsa046600.88825336
92Ovarian steroidogenesis_Homo sapiens_hsa049130.88669486
93Arachidonic acid metabolism_Homo sapiens_hsa005900.88376561
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.87542783
95Retinol metabolism_Homo sapiens_hsa008300.87387170
96Cardiac muscle contraction_Homo sapiens_hsa042600.87333207
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86997846
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85523143
99Calcium signaling pathway_Homo sapiens_hsa040200.84631981
100Allograft rejection_Homo sapiens_hsa053300.83334367
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.83184836
102Protein export_Homo sapiens_hsa030600.81644652
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79953250
104mTOR signaling pathway_Homo sapiens_hsa041500.79027906
105Alzheimers disease_Homo sapiens_hsa050100.78321186
106Notch signaling pathway_Homo sapiens_hsa043300.78030234
107Shigellosis_Homo sapiens_hsa051310.77577286
108Histidine metabolism_Homo sapiens_hsa003400.76775325
109Hematopoietic cell lineage_Homo sapiens_hsa046400.76586552
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76223443
111Thyroid cancer_Homo sapiens_hsa052160.75536235
112Graft-versus-host disease_Homo sapiens_hsa053320.75080978
113Salivary secretion_Homo sapiens_hsa049700.74197080
114Viral myocarditis_Homo sapiens_hsa054160.73685877
115Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72699307
116FoxO signaling pathway_Homo sapiens_hsa040680.71986768
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70701039
118Osteoclast differentiation_Homo sapiens_hsa043800.68178837
119Hepatitis C_Homo sapiens_hsa051600.67204345
120Non-small cell lung cancer_Homo sapiens_hsa052230.66588912
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66483622
122Biosynthesis of amino acids_Homo sapiens_hsa012300.65800043
123Long-term depression_Homo sapiens_hsa047300.65523511
124Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65042722
125Toxoplasmosis_Homo sapiens_hsa051450.63903463
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62126177
127Purine metabolism_Homo sapiens_hsa002300.61259078
128Collecting duct acid secretion_Homo sapiens_hsa049660.60767713
129beta-Alanine metabolism_Homo sapiens_hsa004100.60500648
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58796510
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58337811
132Pancreatic cancer_Homo sapiens_hsa052120.57673006
133Oocyte meiosis_Homo sapiens_hsa041140.57554764
134Fat digestion and absorption_Homo sapiens_hsa049750.56688072
135Dopaminergic synapse_Homo sapiens_hsa047280.56009454
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55407995
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54352459
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54205345
139Autoimmune thyroid disease_Homo sapiens_hsa053200.53555764
140Staphylococcus aureus infection_Homo sapiens_hsa051500.53383117
141TNF signaling pathway_Homo sapiens_hsa046680.53371837
142HIF-1 signaling pathway_Homo sapiens_hsa040660.52772288
143Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52563267
144Metabolic pathways_Homo sapiens_hsa011000.52415199
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.52372766
146Colorectal cancer_Homo sapiens_hsa052100.52257438
147Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51429125
148Sulfur metabolism_Homo sapiens_hsa009200.51388990
149Vitamin digestion and absorption_Homo sapiens_hsa049770.50429211
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.50170640
151Dorso-ventral axis formation_Homo sapiens_hsa043200.49934474
152Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49315344
153Cysteine and methionine metabolism_Homo sapiens_hsa002700.48063162
154Pentose phosphate pathway_Homo sapiens_hsa000300.47834750
155Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45047961
156Maturity onset diabetes of the young_Homo sapiens_hsa049500.44250084
157Cholinergic synapse_Homo sapiens_hsa047250.43696039
158Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42166635
159Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41315330
160Prolactin signaling pathway_Homo sapiens_hsa049170.40854509
161Regulation of autophagy_Homo sapiens_hsa041400.40589562
162Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40289104
163Neurotrophin signaling pathway_Homo sapiens_hsa047220.39526654
164Type I diabetes mellitus_Homo sapiens_hsa049400.38643061
165Inositol phosphate metabolism_Homo sapiens_hsa005620.37405823
166Mineral absorption_Homo sapiens_hsa049780.36892222
167Insulin resistance_Homo sapiens_hsa049310.36867361
168Prostate cancer_Homo sapiens_hsa052150.36283543
169Endometrial cancer_Homo sapiens_hsa052130.35499491
170cAMP signaling pathway_Homo sapiens_hsa040240.35136795
171Gastric acid secretion_Homo sapiens_hsa049710.34785161
172Oxytocin signaling pathway_Homo sapiens_hsa049210.34781464
173Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34359601
174Cocaine addiction_Homo sapiens_hsa050300.34317187
175Sulfur relay system_Homo sapiens_hsa041220.34080354
176Cyanoamino acid metabolism_Homo sapiens_hsa004600.33937117
177Fatty acid biosynthesis_Homo sapiens_hsa000610.33723205
178Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31623389

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