ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	8.40356624
2	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	8.40356624
3	homocysteine metabolic process (GO:0050667)	5.75566430
4	sulfur amino acid catabolic process (GO:0000098)	5.48416074
5	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.04331871
6	NADH dehydrogenase complex assembly (GO:0010257)	5.04331871
7	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.04331871
8	L-serine metabolic process (GO:0006563)	4.78457588
9	adenosine metabolic process (GO:0046085)	4.57861178
10	folic acid-containing compound biosynthetic process (GO:0009396)	4.56766895
11	serine family amino acid catabolic process (GO:0009071)	4.48711408
12	regulation of plasminogen activation (GO:0010755)	4.44713643
13	protein complex biogenesis (GO:0070271)	4.33541420
14	pseudouridine synthesis (GO:0001522)	4.27804210
15	behavioral response to nicotine (GO:0035095)	4.24472957
16	cysteine metabolic process (GO:0006534)	4.12902019
17	ribosomal small subunit assembly (GO:0000028)	4.09004680
18	mitochondrial respiratory chain complex assembly (GO:0033108)	3.88576660
19	ATP synthesis coupled proton transport (GO:0015986)	3.83990408
20	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.83990408
21	purine nucleotide salvage (GO:0032261)	3.76047567
22	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.70646153
23	primary amino compound metabolic process (GO:1901160)	3.67078181
24	chaperone-mediated protein transport (GO:0072321)	3.57769114
25	protein-cofactor linkage (GO:0018065)	3.57371068
26	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.51130643
27	phosphate ion homeostasis (GO:0055062)	3.50519523
28	trivalent inorganic anion homeostasis (GO:0072506)	3.50519523
29	organic cation transport (GO:0015695)	3.47211261
30	glyoxylate metabolic process (GO:0046487)	3.45315225
31	serine family amino acid biosynthetic process (GO:0009070)	3.45287953
32	cochlea development (GO:0090102)	3.44697820
33	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.39449576
34	rRNA modification (GO:0000154)	3.38685759
35	GTP biosynthetic process (GO:0006183)	3.36606241
36	negative regulation of DNA biosynthetic process (GO:2000279)	3.36290701
37	pteridine-containing compound biosynthetic process (GO:0042559)	3.35313471
38	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.34253595
39	white fat cell differentiation (GO:0050872)	3.33827253
40	microtubule nucleation (GO:0007020)	3.31402533
41	mitochondrial RNA metabolic process (GO:0000959)	3.31106154
42	tetrahydrofolate metabolic process (GO:0046653)	3.30284231
43	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.25483124
44	norepinephrine metabolic process (GO:0042415)	3.18446456
45	negative regulation of Ras GTPase activity (GO:0034261)	3.18185221
46	maturation of 5.8S rRNA (GO:0000460)	3.17995001
47	nucleotide salvage (GO:0043173)	3.17514265
48	tRNA processing (GO:0008033)	3.16686103
49	protein localization to cilium (GO:0061512)	3.13703015
50	base-excision repair, AP site formation (GO:0006285)	3.07403951
51	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.04181528
52	respiratory electron transport chain (GO:0022904)	3.01929314
53	inner mitochondrial membrane organization (GO:0007007)	3.01806304
54	pyrimidine nucleotide catabolic process (GO:0006244)	3.01374973
55	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.00763529
56	negative regulation of telomere maintenance (GO:0032205)	2.99579111
57	isoprenoid biosynthetic process (GO:0008299)	2.98122995
58	electron transport chain (GO:0022900)	2.97154265
59	preassembly of GPI anchor in ER membrane (GO:0016254)	2.94353727
60	tRNA modification (GO:0006400)	2.91769987
61	GMP metabolic process (GO:0046037)	2.91201926
62	respiratory chain complex IV assembly (GO:0008535)	2.89969600
63	platelet dense granule organization (GO:0060155)	2.89255496
64	viral transcription (GO:0019083)	2.86820905
65	water-soluble vitamin biosynthetic process (GO:0042364)	2.84644725
66	rRNA methylation (GO:0031167)	2.84310399
67	alternative mRNA splicing, via spliceosome (GO:0000380)	2.83786923
68	UTP biosynthetic process (GO:0006228)	2.82770437
69	protein deneddylation (GO:0000338)	2.82321363
70	cellular component biogenesis (GO:0044085)	2.80218458
71	kynurenine metabolic process (GO:0070189)	2.80185246
72	cullin deneddylation (GO:0010388)	2.78398902
73	positive regulation of mitochondrial fission (GO:0090141)	2.77106036
74	protein polyglutamylation (GO:0018095)	2.76419922
75	translational termination (GO:0006415)	2.75128725
76	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.74278526
77	ATP hydrolysis coupled proton transport (GO:0015991)	2.74278526
78	heart contraction (GO:0060047)	2.74014101
79	heart process (GO:0003015)	2.74014101
80	UTP metabolic process (GO:0046051)	2.73245177
81	phosphatidylglycerol biosynthetic process (GO:0006655)	2.70784522
82	folic acid-containing compound metabolic process (GO:0006760)	2.69660779
83	behavioral defense response (GO:0002209)	2.69637209
84	behavioral fear response (GO:0001662)	2.69637209
85	sulfur amino acid biosynthetic process (GO:0000097)	2.67649073
86	serine family amino acid metabolic process (GO:0009069)	2.66243986
87	cellular modified amino acid catabolic process (GO:0042219)	2.64519964
88	response to gravity (GO:0009629)	2.64078039
89	guanosine-containing compound biosynthetic process (GO:1901070)	2.63242730
90	protein targeting to mitochondrion (GO:0006626)	2.63211600
91	CTP biosynthetic process (GO:0006241)	2.61204258
92	CTP metabolic process (GO:0046036)	2.61204258
93	regulation of telomerase activity (GO:0051972)	2.60958089
94	arginine metabolic process (GO:0006525)	2.60839563
95	alkaloid metabolic process (GO:0009820)	2.58323317
96	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.56582131
97	inner ear receptor cell development (GO:0060119)	2.54938056
98	pyrimidine nucleobase catabolic process (GO:0006208)	2.54735455
99	proteasome assembly (GO:0043248)	2.54500088
100	proline transport (GO:0015824)	2.54173054

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.45551269
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.68877626
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.46376113
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.09937450
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.87702038
6	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.85075718
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.84931382
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.75191606
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.61076950
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.58634261
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.54213569
12	VDR_22108803_ChIP-Seq_LS180_Human	2.32983784
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.26061658
14	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.12537730
15	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.04801777
16	TP53_22573176_ChIP-Seq_HFKS_Human	1.91546779
17	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.73285482
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.70319154
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.63561718
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.61032368
21	GABP_19822575_ChIP-Seq_HepG2_Human	1.56871259
22	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.52304619
23	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.51328455
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.49129845
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.47141696
26	STAT1_20625510_ChIP-Seq_HELA_Human	1.44183193
27	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.44138160
28	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44108099
29	NCOR_22424771_ChIP-Seq_293T_Human	1.43165010
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.42179877
31	EWS_26573619_Chip-Seq_HEK293_Human	1.39431971
32	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.38344368
33	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.38313074
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.36279840
35	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.31436596
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.29660162
37	REST_21632747_ChIP-Seq_MESCs_Mouse	1.26224849
38	TAF2_19829295_ChIP-Seq_ESCs_Human	1.26073065
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.25531202
40	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25469035
41	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.21267728
42	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.21242530
43	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.20971969
44	BCAT_22108803_ChIP-Seq_LS180_Human	1.20807917
45	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.20297782
46	ELK1_19687146_ChIP-ChIP_HELA_Human	1.18922008
47	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.17879442
48	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.17514610
49	GBX2_23144817_ChIP-Seq_PC3_Human	1.17417728
50	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.16890106
51	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.16767907
52	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.15886538
53	MYC_18940864_ChIP-ChIP_HL60_Human	1.14785008
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.14780215
55	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.12029702
56	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.11564692
57	FUS_26573619_Chip-Seq_HEK293_Human	1.11213813
58	CIITA_25753668_ChIP-Seq_RAJI_Human	1.10389665
59	P300_19829295_ChIP-Seq_ESCs_Human	1.09579584
60	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.09119169
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.08884438
62	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08780367
63	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.07164360
64	ER_23166858_ChIP-Seq_MCF-7_Human	1.07094280
65	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.06836797
66	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.06822636
67	ERA_21632823_ChIP-Seq_H3396_Human	1.04850562
68	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.04744618
69	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02401071
70	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.01957618
71	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.01697342
72	CDX2_22108803_ChIP-Seq_LS180_Human	1.00330844
73	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.00311414
74	XRN2_22483619_ChIP-Seq_HELA_Human	0.99929597
75	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.99016431
76	RUNX2_22187159_ChIP-Seq_PCA_Human	0.98663701
77	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.97791309
78	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.97736244
79	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.94392495
80	TTF2_22483619_ChIP-Seq_HELA_Human	0.94340334
81	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.94250309
82	AR_20517297_ChIP-Seq_VCAP_Human	0.93810228
83	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.93580849
84	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.91964221
85	MYC_19829295_ChIP-Seq_ESCs_Human	0.91927219
86	NANOG_20526341_ChIP-Seq_ESCs_Human	0.91225049
87	TAF15_26573619_Chip-Seq_HEK293_Human	0.90599709
88	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.90333832
89	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.88989389
90	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.88508858
91	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.88142983
92	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.88142983
93	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.88110433
94	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.87957282
95	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.87779874
96	TCF4_22108803_ChIP-Seq_LS180_Human	0.87271723
97	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.87222334
98	CEBPB_22108803_ChIP-Seq_LS180_Human	0.86030925
99	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.85524248
100	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.84700772

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002138_abnormal_hepatobiliary_system	5.81808143
2	MP0005360_urolithiasis	3.35380726
3	MP0001968_abnormal_touch/_nociception	2.99624165
4	MP0002736_abnormal_nociception_after	2.88119617
5	MP0005646_abnormal_pituitary_gland	2.80750541
6	MP0004145_abnormal_muscle_electrophysio	2.33672283
7	MP0002938_white_spotting	2.32070728
8	MP0003186_abnormal_redox_activity	2.29469470
9	MP0004885_abnormal_endolymph	2.27365201
10	MP0003122_maternal_imprinting	2.16470988
11	MP0005551_abnormal_eye_electrophysiolog	2.09258911
12	MP0004147_increased_porphyrin_level	2.08892121
13	MP0008872_abnormal_physiological_respon	2.07004014
14	MP0002837_dystrophic_cardiac_calcinosis	2.05174787
15	MP0008995_early_reproductive_senescence	1.99069033
16	MP0005167_abnormal_blood-brain_barrier	1.98422834
17	MP0002139_abnormal_hepatobiliary_system	1.95443715
18	MP0008875_abnormal_xenobiotic_pharmacok	1.94316900
19	MP0003121_genomic_imprinting	1.93806733
20	MP0005670_abnormal_white_adipose	1.91240975
21	MP0002653_abnormal_ependyma_morphology	1.87639805
22	MP0003183_abnormal_peptide_metabolism	1.85743318
23	MP0003806_abnormal_nucleotide_metabolis	1.84674843
24	MP0002638_abnormal_pupillary_reflex	1.80680060
25	MP0002102_abnormal_ear_morphology	1.80082743
26	MP0006292_abnormal_olfactory_placode	1.61867903
27	MP0001661_extended_life_span	1.60998751
28	MP0005645_abnormal_hypothalamus_physiol	1.59176111
29	MP0005085_abnormal_gallbladder_physiolo	1.49998158
30	MP0003786_premature_aging	1.49157125
31	MP0004043_abnormal_pH_regulation	1.44686714
32	MP0003878_abnormal_ear_physiology	1.40854449
33	MP0005377_hearing/vestibular/ear_phenot	1.40854449
34	MP0004142_abnormal_muscle_tone	1.38368153
35	MP0006276_abnormal_autonomic_nervous	1.37857527
36	MP0000013_abnormal_adipose_tissue	1.34946231
37	MP0005332_abnormal_amino_acid	1.34809129
38	MP0002095_abnormal_skin_pigmentation	1.34211714
39	MP0009745_abnormal_behavioral_response	1.31356571
40	MP0002272_abnormal_nervous_system	1.27342065
41	MP0009379_abnormal_foot_pigmentation	1.26332270
42	MP0009046_muscle_twitch	1.24713338
43	MP0003123_paternal_imprinting	1.22341828
44	MP0001764_abnormal_homeostasis	1.20822805
45	MP0003880_abnormal_central_pattern	1.19812216
46	MP0005084_abnormal_gallbladder_morpholo	1.19590449
47	MP0002184_abnormal_innervation	1.19190177
48	MP0001486_abnormal_startle_reflex	1.18239877
49	MP0001440_abnormal_grooming_behavior	1.17455823
50	MP0002735_abnormal_chemical_nociception	1.17141814
51	MP0001905_abnormal_dopamine_level	1.15962401
52	MP0002733_abnormal_thermal_nociception	1.15685322
53	MP0005253_abnormal_eye_physiology	1.13001767
54	MP0000516_abnormal_urinary_system	1.11898181
55	MP0005367_renal/urinary_system_phenotyp	1.11898181
56	MP0004133_heterotaxia	1.11802526
57	MP0002734_abnormal_mechanical_nocicepti	1.11593178
58	MP0000372_irregular_coat_pigmentation	1.08823762
59	MP0002572_abnormal_emotion/affect_behav	1.07793551
60	MP0005365_abnormal_bile_salt	1.07743185
61	MP0005220_abnormal_exocrine_pancreas	1.07639233
62	MP0003787_abnormal_imprinting	1.05918385
63	MP0003195_calcinosis	1.05762291
64	MP0000647_abnormal_sebaceous_gland	1.05733353
65	MP0006072_abnormal_retinal_apoptosis	1.04038282
66	MP0002160_abnormal_reproductive_system	1.03414003
67	MP0005195_abnormal_posterior_eye	1.00396308
68	MP0001986_abnormal_taste_sensitivity	0.98795573
69	MP0008058_abnormal_DNA_repair	0.96313453
70	MP0002063_abnormal_learning/memory/cond	0.95337489
71	MP0001944_abnormal_pancreas_morphology	0.94876495
72	MP0001970_abnormal_pain_threshold	0.94151172
73	MP0003011_delayed_dark_adaptation	0.93544416
74	MP0000750_abnormal_muscle_regeneration	0.91493442
75	MP0000026_abnormal_inner_ear	0.87873050
76	MP0010368_abnormal_lymphatic_system	0.87609896
77	MP0008789_abnormal_olfactory_epithelium	0.87326127
78	MP0005423_abnormal_somatic_nervous	0.87250464
79	MP0002928_abnormal_bile_duct	0.86924124
80	MP0009697_abnormal_copulation	0.85533435
81	MP0002752_abnormal_somatic_nervous	0.84674282
82	MP0003252_abnormal_bile_duct	0.84338489
83	MP0002557_abnormal_social/conspecific_i	0.83869805
84	MP0005394_taste/olfaction_phenotype	0.83438940
85	MP0005499_abnormal_olfactory_system	0.83438940
86	MP0000631_abnormal_neuroendocrine_gland	0.83397919
87	MP0002229_neurodegeneration	0.82724642
88	MP0006036_abnormal_mitochondrial_physio	0.80590630
89	MP0003635_abnormal_synaptic_transmissio	0.80164652
90	MP0002069_abnormal_eating/drinking_beha	0.79187392
91	MP0003646_muscle_fatigue	0.78390361
92	MP0005389_reproductive_system_phenotype	0.75920753
93	MP0000778_abnormal_nervous_system	0.74919868
94	MP0000613_abnormal_salivary_gland	0.74423591
95	MP0002067_abnormal_sensory_capabilities	0.73495985
96	MP0001963_abnormal_hearing_physiology	0.72840903
97	MP0000955_abnormal_spinal_cord	0.70386174
98	MP0004019_abnormal_vitamin_homeostasis	0.69937518
99	MP0001919_abnormal_reproductive_system	0.69543603
100	MP0004185_abnormal_adipocyte_glucose	0.69298604

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	5.41134916
2	Abnormality of alanine metabolism (HP:0010916)	5.41134916
3	Hyperalaninemia (HP:0003348)	5.41134916
4	Pancreatic fibrosis (HP:0100732)	4.06451371
5	Acute necrotizing encephalopathy (HP:0006965)	3.96949810
6	Constricted visual fields (HP:0001133)	3.62965525
7	Abnormality of midbrain morphology (HP:0002418)	3.51590331
8	Molar tooth sign on MRI (HP:0002419)	3.51590331
9	Mitochondrial inheritance (HP:0001427)	3.45211737
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.45032179
11	Acute encephalopathy (HP:0006846)	3.41769453
12	True hermaphroditism (HP:0010459)	3.39085945
13	Progressive macrocephaly (HP:0004481)	3.36727229
14	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.22372375
15	Pancreatic cysts (HP:0001737)	3.18027647
16	Congenital stationary night blindness (HP:0007642)	3.14286172
17	Elevated erythrocyte sedimentation rate (HP:0003565)	3.06775128
18	Increased CSF lactate (HP:0002490)	3.05218201
19	Generalized aminoaciduria (HP:0002909)	3.01020559
20	Renal Fanconi syndrome (HP:0001994)	3.00863265
21	Congenital sensorineural hearing impairment (HP:0008527)	2.98836189
22	Increased hepatocellular lipid droplets (HP:0006565)	2.93926775
23	Cerebral edema (HP:0002181)	2.92565055
24	Pendular nystagmus (HP:0012043)	2.86872863
25	Bile duct proliferation (HP:0001408)	2.86237555
26	Abnormal biliary tract physiology (HP:0012439)	2.86237555
27	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.84723332
28	Chronic hepatic failure (HP:0100626)	2.80831285
29	Hyperphosphaturia (HP:0003109)	2.80261889
30	Hepatocellular necrosis (HP:0001404)	2.79746466
31	Hepatic necrosis (HP:0002605)	2.73399450
32	Cystic liver disease (HP:0006706)	2.69251803
33	Action tremor (HP:0002345)	2.69048375
34	Congenital, generalized hypertrichosis (HP:0004540)	2.66352549
35	Conjugated hyperbilirubinemia (HP:0002908)	2.62624365
36	Prostate neoplasm (HP:0100787)	2.61596378
37	Oligomenorrhea (HP:0000876)	2.58220961
38	Nephronophthisis (HP:0000090)	2.53624496
39	Reticulocytopenia (HP:0001896)	2.52525921
40	Lipid accumulation in hepatocytes (HP:0006561)	2.50754004
41	Glycosuria (HP:0003076)	2.49270823
42	Abnormality of urine glucose concentration (HP:0011016)	2.49270823
43	Lactic acidosis (HP:0003128)	2.46769257
44	Abnormality of serum amino acid levels (HP:0003112)	2.41611239
45	Abnormality of the labia minora (HP:0012880)	2.41539526
46	Myokymia (HP:0002411)	2.40561735
47	Pigmentary retinal degeneration (HP:0001146)	2.39919222
48	Keratoconus (HP:0000563)	2.39874130
49	Increased corneal curvature (HP:0100692)	2.39874130
50	Anencephaly (HP:0002323)	2.39625432
51	Proximal tubulopathy (HP:0000114)	2.37942526
52	Abnormality of cells of the erythroid lineage (HP:0012130)	2.30449063
53	Dry hair (HP:0011359)	2.27913462
54	Hyperglycinemia (HP:0002154)	2.26926063
55	Tubulointerstitial nephritis (HP:0001970)	2.25522895
56	Abnormal respiratory epithelium morphology (HP:0012253)	2.23777508
57	Abnormal respiratory motile cilium morphology (HP:0005938)	2.23777508
58	Increased serum lactate (HP:0002151)	2.20775883
59	Abnormality of the renal medulla (HP:0100957)	2.10975493
60	Esophageal varix (HP:0002040)	2.10130230
61	Congenital hepatic fibrosis (HP:0002612)	2.08745926
62	Abnormality of homocysteine metabolism (HP:0010919)	2.07063495
63	Homocystinuria (HP:0002156)	2.07063495
64	Medial flaring of the eyebrow (HP:0010747)	2.06801321
65	Decreased muscle mass (HP:0003199)	2.06677768
66	Sclerocornea (HP:0000647)	2.05589921
67	Abnormal urine phosphate concentration (HP:0012599)	2.05021706
68	Fair hair (HP:0002286)	2.01047165
69	Colon cancer (HP:0003003)	2.00425553
70	Abnormal rod and cone electroretinograms (HP:0008323)	1.99065621
71	Spontaneous hematomas (HP:0007420)	1.99006994
72	Abolished electroretinogram (ERG) (HP:0000550)	1.97157854
73	Lethargy (HP:0001254)	1.96665924
74	Increased intramyocellular lipid droplets (HP:0012240)	1.95850480
75	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.95793054
76	Progressive cerebellar ataxia (HP:0002073)	1.95583164
77	Optic disc pallor (HP:0000543)	1.92977666
78	Abnormality of renal resorption (HP:0011038)	1.91314698
79	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.90596031
80	Polydipsia (HP:0001959)	1.90115377
81	Abnormal drinking behavior (HP:0030082)	1.90115377
82	Optic nerve coloboma (HP:0000588)	1.89748173
83	Dyskinesia (HP:0100660)	1.87745422
84	Maternal diabetes (HP:0009800)	1.86922041
85	Abnormality of DNA repair (HP:0003254)	1.85953882
86	Reduced antithrombin III activity (HP:0001976)	1.83209943
87	Metabolic acidosis (HP:0001942)	1.83142597
88	Abnormal number of erythroid precursors (HP:0012131)	1.82963395
89	Male pseudohermaphroditism (HP:0000037)	1.81061167
90	Increased serum pyruvate (HP:0003542)	1.80964111
91	Ulnar claw (HP:0001178)	1.80361053
92	Poor speech (HP:0002465)	1.77809993
93	Small hand (HP:0200055)	1.77018256
94	Nephrogenic diabetes insipidus (HP:0009806)	1.76340754
95	Methylmalonic acidemia (HP:0002912)	1.76012558
96	Oral leukoplakia (HP:0002745)	1.75976907
97	Hypokinesia (HP:0002375)	1.73732135
98	Ketosis (HP:0001946)	1.72150203
99	Gait imbalance (HP:0002141)	1.71725145
100	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.71187883

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.92375011
2	TIE1	3.34509725
3	NTRK3	3.26439225
4	FRK	2.87066179
5	VRK2	2.63882714
6	DYRK2	2.52757567
7	BCKDK	2.48038072
8	TLK1	2.48028869
9	EIF2AK1	2.31473442
10	GRK1	2.12794525
11	NUAK1	1.97500896
12	TAF1	1.96076504
13	PHKG1	1.91998576
14	PHKG2	1.91998576
15	WNK4	1.75753253
16	SGK223	1.53983645
17	SGK494	1.53983645
18	ADRBK2	1.51891533
19	NTRK2	1.40761905
20	MAPK13	1.39827712
21	CDK9	1.38884906
22	ACVR1B	1.38421024
23	PRKD3	1.38069224
24	VRK1	1.33517490
25	MARK1	1.28846247
26	CSNK1G3	1.25433319
27	CDK19	1.23535103
28	PRKCG	1.17195497
29	PAK3	1.14815220
30	PIK3CA	1.12230036
31	PLK2	1.12127292
32	OXSR1	1.11342220
33	PDK2	1.10086228
34	ZAK	1.06585835
35	ADRBK1	1.04439318
36	SGK2	1.01626432
37	WNK3	1.01076908
38	CSNK1A1L	1.00820431
39	BMPR1B	1.00651952
40	MAP3K3	0.98841112
41	CCNB1	0.95346595
42	CSNK1G2	0.95304431
43	CSNK1G1	0.90642916
44	EPHB2	0.90055458
45	STK39	0.88907098
46	INSRR	0.88599674
47	RPS6KB2	0.87987999
48	PINK1	0.86612893
49	PRKCE	0.86515456
50	PRKCI	0.81475977
51	MAP2K3	0.79966518
52	GRK5	0.79962209
53	LIMK1	0.79883168
54	CSNK1A1	0.77293207
55	BCR	0.70587488
56	EPHA4	0.70092724
57	PRKCQ	0.68996078
58	MINK1	0.68644138
59	CAMK2D	0.67435502
60	CDC7	0.67233936
61	DYRK3	0.66136450
62	JAK3	0.65086894
63	FGR	0.64675172
64	SIK2	0.63736152
65	CAMK1	0.62986778
66	NME2	0.61594757
67	PRKACA	0.60615669
68	MAP3K11	0.59977999
69	PLK3	0.59836232
70	DYRK1A	0.57937595
71	ATR	0.57864723
72	MAPKAPK5	0.56134267
73	NME1	0.55417421
74	PRKCD	0.53920887
75	LRRK2	0.53904937
76	AURKA	0.53438040
77	PRKCA	0.53197680
78	CAMKK2	0.51871537
79	PRKCZ	0.49711213
80	CDK14	0.49190229
81	DMPK	0.48903214
82	CSNK2A2	0.48537317
83	SGK1	0.48344089
84	ERN1	0.48086018
85	DAPK2	0.47138163
86	MAP2K1	0.45932121
87	BRAF	0.43708457
88	DAPK3	0.42829252
89	CAMK2A	0.42406418
90	CSNK2A1	0.41366927
91	BRD4	0.40667996
92	CDK11A	0.40648177
93	ILK	0.39350731
94	DAPK1	0.39126143
95	PRKCH	0.37676175
96	RAF1	0.36616912
97	ARAF	0.35801222
98	CDK15	0.35368122
99	CLK1	0.34110817
100	RPS6KB1	0.33178375

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.45538901
2	One carbon pool by folate_Homo sapiens_hsa00670	3.08077772
3	Sulfur metabolism_Homo sapiens_hsa00920	2.79177946
4	Ribosome_Homo sapiens_hsa03010	2.68313963
5	Parkinsons disease_Homo sapiens_hsa05012	2.51683257
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.45767349
7	Proteasome_Homo sapiens_hsa03050	2.45556676
8	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.31238919
9	Sulfur relay system_Homo sapiens_hsa04122	2.13199715
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.11638784
11	Arginine biosynthesis_Homo sapiens_hsa00220	1.96457556
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.96267491
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.95969065
14	Steroid biosynthesis_Homo sapiens_hsa00100	1.92373821
15	Huntingtons disease_Homo sapiens_hsa05016	1.88654567
16	Collecting duct acid secretion_Homo sapiens_hsa04966	1.87108718
17	Protein export_Homo sapiens_hsa03060	1.83567178
18	Alzheimers disease_Homo sapiens_hsa05010	1.81336049
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.73732595
20	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.70066516
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.64499644
22	RNA polymerase_Homo sapiens_hsa03020	1.63975784
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.58774151
24	Butanoate metabolism_Homo sapiens_hsa00650	1.57581330
25	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.56169139
26	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.52510276
27	Peroxisome_Homo sapiens_hsa04146	1.40595150
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.39706826
29	Phototransduction_Homo sapiens_hsa04744	1.38807681
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.38352463
31	Morphine addiction_Homo sapiens_hsa05032	1.34388834
32	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.28503488
33	Basal transcription factors_Homo sapiens_hsa03022	1.26158343
34	Retinol metabolism_Homo sapiens_hsa00830	1.26001887
35	Propanoate metabolism_Homo sapiens_hsa00640	1.23325735
36	Base excision repair_Homo sapiens_hsa03410	1.23046762
37	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.20181151
38	Nicotine addiction_Homo sapiens_hsa05033	1.19868181
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.19340129
40	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.15857503
41	Ether lipid metabolism_Homo sapiens_hsa00565	1.10832270
42	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.06698080
43	GABAergic synapse_Homo sapiens_hsa04727	1.05805460
44	Cardiac muscle contraction_Homo sapiens_hsa04260	1.05394012
45	Selenocompound metabolism_Homo sapiens_hsa00450	1.03593100
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.00001406
47	Pyrimidine metabolism_Homo sapiens_hsa00240	0.99713191
48	Pyruvate metabolism_Homo sapiens_hsa00620	0.97677809
49	Asthma_Homo sapiens_hsa05310	0.97536834
50	RNA degradation_Homo sapiens_hsa03018	0.96889299
51	Metabolic pathways_Homo sapiens_hsa01100	0.95102187
52	Folate biosynthesis_Homo sapiens_hsa00790	0.94212576
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.91582502
54	Tryptophan metabolism_Homo sapiens_hsa00380	0.91449732
55	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.88041836
56	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.85308320
57	Fat digestion and absorption_Homo sapiens_hsa04975	0.83936878
58	Purine metabolism_Homo sapiens_hsa00230	0.82926271
59	Arginine and proline metabolism_Homo sapiens_hsa00330	0.81306508
60	Glutamatergic synapse_Homo sapiens_hsa04724	0.80882085
61	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.76419042
62	Homologous recombination_Homo sapiens_hsa03440	0.73471904
63	Serotonergic synapse_Homo sapiens_hsa04726	0.72957260
64	Circadian entrainment_Homo sapiens_hsa04713	0.71287334
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.71206983
66	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.70298600
67	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.68875758
68	Fatty acid degradation_Homo sapiens_hsa00071	0.68611699
69	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.66135544
70	Fanconi anemia pathway_Homo sapiens_hsa03460	0.65945299
71	Fatty acid metabolism_Homo sapiens_hsa01212	0.65006264
72	Rheumatoid arthritis_Homo sapiens_hsa05323	0.64425849
73	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.64399787
74	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.63658987
75	Olfactory transduction_Homo sapiens_hsa04740	0.63555592
76	Taste transduction_Homo sapiens_hsa04742	0.62982200
77	Regulation of autophagy_Homo sapiens_hsa04140	0.61555771
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.61159572
79	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.60779379
80	Dopaminergic synapse_Homo sapiens_hsa04728	0.59505727
81	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.59176215
82	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.57720867
83	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.55081600
84	Type I diabetes mellitus_Homo sapiens_hsa04940	0.53355955
85	Glutathione metabolism_Homo sapiens_hsa00480	0.52920433
86	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.51788079
87	Spliceosome_Homo sapiens_hsa03040	0.51168041
88	Carbon metabolism_Homo sapiens_hsa01200	0.50435439
89	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.49819736
90	Mismatch repair_Homo sapiens_hsa03430	0.48116632
91	Phenylalanine metabolism_Homo sapiens_hsa00360	0.45514380
92	Tyrosine metabolism_Homo sapiens_hsa00350	0.44544251
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43444353
94	RNA transport_Homo sapiens_hsa03013	0.41711675
95	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.41654547
96	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40899362
97	Allograft rejection_Homo sapiens_hsa05330	0.40880091
98	Graft-versus-host disease_Homo sapiens_hsa05332	0.40613695
99	Vibrio cholerae infection_Homo sapiens_hsa05110	0.38604515
100	Insulin secretion_Homo sapiens_hsa04911	0.36696602

HINT1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »