HINT1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)6.66780552
2muscle atrophy (GO:0014889)6.22082075
3peroxisome fission (GO:0016559)5.87386181
4tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.85322672
5RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.85322672
6alternative mRNA splicing, via spliceosome (GO:0000380)5.79524660
7homocysteine metabolic process (GO:0050667)5.53525091
8skeletal muscle adaptation (GO:0043501)5.47660901
9striated muscle atrophy (GO:0014891)5.42360304
10regulation of plasminogen activation (GO:0010755)5.35962581
11positive regulation of mitochondrial fission (GO:0090141)4.93207614
12white fat cell differentiation (GO:0050872)4.71985035
13folic acid-containing compound biosynthetic process (GO:0009396)4.67416745
14purine nucleotide salvage (GO:0032261)4.63301718
15sulfur amino acid catabolic process (GO:0000098)4.57574493
16serine family amino acid catabolic process (GO:0009071)4.35944660
17microtubule nucleation (GO:0007020)4.29747376
18cysteine metabolic process (GO:0006534)4.29480960
19adaptation of signaling pathway (GO:0023058)4.25561302
20negative regulation of DNA biosynthetic process (GO:2000279)4.20871323
21mitochondrial fragmentation involved in apoptotic process (GO:0043653)4.18854250
22pteridine-containing compound biosynthetic process (GO:0042559)4.18063243
23negative regulation of keratinocyte proliferation (GO:0010839)4.10224780
24regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.09442189
25response to gravity (GO:0009629)4.07915515
26regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.07020658
27secondary heart field specification (GO:0003139)4.01498794
28heart field specification (GO:0003128)4.01498794
29labyrinthine layer blood vessel development (GO:0060716)3.95554768
30adenosine metabolic process (GO:0046085)3.90623066
31platelet dense granule organization (GO:0060155)3.88033439
32L-serine metabolic process (GO:0006563)3.86706924
33skeletal muscle tissue regeneration (GO:0043403)3.83649181
34cell wall macromolecule catabolic process (GO:0016998)3.69852023
35cartilage morphogenesis (GO:0060536)3.67030706
36ventricular trabecula myocardium morphogenesis (GO:0003222)3.63238766
37nucleoside transmembrane transport (GO:1901642)3.58207570
38negative regulation of muscle hypertrophy (GO:0014741)3.44674780
39prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.37809158
40single strand break repair (GO:0000012)3.34931948
41DNA replication-independent nucleosome assembly (GO:0006336)3.34863169
42DNA replication-independent nucleosome organization (GO:0034724)3.34863169
43protein K6-linked ubiquitination (GO:0085020)3.34688522
44chromatin remodeling at centromere (GO:0031055)3.32006983
45epithelial cell fate commitment (GO:0072148)3.31565279
46negative regulation of telomerase activity (GO:0051974)3.31312003
47regulation of mitochondrial fission (GO:0090140)3.31073040
48folic acid-containing compound metabolic process (GO:0006760)3.30693785
49mitochondrial RNA metabolic process (GO:0000959)3.30137547
50cochlea development (GO:0090102)3.28230942
51replication fork processing (GO:0031297)3.23279521
52positive regulation of endothelial cell differentiation (GO:0045603)3.21426144
53pteridine-containing compound metabolic process (GO:0042558)3.21154562
54tetrahydrofolate metabolic process (GO:0046653)3.20389066
55CENP-A containing nucleosome assembly (GO:0034080)3.14524779
56maturation of SSU-rRNA (GO:0030490)3.12072056
57outer ear morphogenesis (GO:0042473)3.11360688
58response to muscle activity (GO:0014850)3.10211697
59phosphatidylglycerol biosynthetic process (GO:0006655)3.09552481
60maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.09195644
61cell wall macromolecule metabolic process (GO:0044036)3.08227849
62IMP biosynthetic process (GO:0006188)3.04573417
63regulation of keratinocyte proliferation (GO:0010837)2.98879360
64inner ear receptor cell development (GO:0060119)2.98589512
65regulation of gonadotropin secretion (GO:0032276)2.98241016
66folic acid transport (GO:0015884)2.95701125
67specification of organ identity (GO:0010092)2.94925846
68histone exchange (GO:0043486)2.94319278
69galactose metabolic process (GO:0006012)2.93372558
70mitochondrial respiratory chain complex I assembly (GO:0032981)2.90997680
71NADH dehydrogenase complex assembly (GO:0010257)2.90997680
72mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.90997680
73protein complex biogenesis (GO:0070271)2.90903899
74serine family amino acid biosynthetic process (GO:0009070)2.90369328
75keratinocyte development (GO:0003334)2.88294973
76energy homeostasis (GO:0097009)2.85979391
77protein-cofactor linkage (GO:0018065)2.85908539
78mRNA splice site selection (GO:0006376)2.84633623
79muscle filament sliding (GO:0030049)2.83784698
80actin-myosin filament sliding (GO:0033275)2.83784698
81heart trabecula morphogenesis (GO:0061384)2.80297234
82pseudouridine synthesis (GO:0001522)2.78473555
83regulation of timing of cell differentiation (GO:0048505)2.77269797
84kynurenine metabolic process (GO:0070189)2.77099208
85negative regulation of Ras GTPase activity (GO:0034261)2.77006717
86peptidyl-arginine N-methylation (GO:0035246)2.75438039
87peptidyl-arginine methylation (GO:0018216)2.75438039
88primary amino compound metabolic process (GO:1901160)2.75270911
89regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.73151051
90protein-chromophore linkage (GO:0018298)2.71111206
91regulation of spindle organization (GO:0090224)2.67479395
92response to folic acid (GO:0051593)2.67156196
93mitochondrion morphogenesis (GO:0070584)2.61885013
94rRNA methylation (GO:0031167)2.61507784
95regulation of mitochondrial translation (GO:0070129)2.57950111
96photoreceptor cell differentiation (GO:0046530)2.57755237
97eye photoreceptor cell differentiation (GO:0001754)2.57755237
98indole-containing compound catabolic process (GO:0042436)2.57710182
99indolalkylamine catabolic process (GO:0046218)2.57710182
100tryptophan catabolic process (GO:0006569)2.57710182

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.01212682
2VDR_22108803_ChIP-Seq_LS180_Human5.09805667
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.57130607
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.23956430
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.73242250
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.52893774
7CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.47313972
8EZH2_22144423_ChIP-Seq_EOC_Human2.39011994
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.33756541
10GBX2_23144817_ChIP-Seq_PC3_Human2.30861220
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.18007910
12FUS_26573619_Chip-Seq_HEK293_Human2.14829591
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14745523
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10152313
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.04415002
16TP53_22573176_ChIP-Seq_HFKS_Human1.85877659
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81828680
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.81577715
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80615995
20POU5F1_16153702_ChIP-ChIP_HESCs_Human1.78856452
21TAF15_26573619_Chip-Seq_HEK293_Human1.78329080
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75228841
23FOXM1_23109430_ChIP-Seq_U2OS_Human1.75068545
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73222644
25RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.72167789
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71599413
27BCAT_22108803_ChIP-Seq_LS180_Human1.68460071
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.64292855
29P300_19829295_ChIP-Seq_ESCs_Human1.63411828
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62898595
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62238843
32MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.60041647
33ELK1_19687146_ChIP-ChIP_HELA_Human1.48514613
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48315538
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45386341
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43926151
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41673362
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38599806
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36849964
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36407905
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35887876
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33079815
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.32925606
44ZNF274_21170338_ChIP-Seq_K562_Hela1.32914536
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30179992
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.28654056
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25460693
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.22049731
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21835618
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20609352
51AR_21572438_ChIP-Seq_LNCaP_Human1.19482614
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17936919
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17881283
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17718154
55RUNX2_22187159_ChIP-Seq_PCA_Human1.17663213
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15649903
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15359663
58STAT3_23295773_ChIP-Seq_U87_Human1.14278806
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11980513
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11589923
61RXR_22108803_ChIP-Seq_LS180_Human1.10992404
62NANOG_19829295_ChIP-Seq_ESCs_Human1.08941039
63SOX2_19829295_ChIP-Seq_ESCs_Human1.08941039
64E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08774556
65EWS_26573619_Chip-Seq_HEK293_Human1.08089896
66NCOR_22424771_ChIP-Seq_293T_Human1.07297827
67EED_16625203_ChIP-ChIP_MESCs_Mouse1.06086067
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05283202
69KDM2B_26808549_Chip-Seq_REH_Human1.04268602
70SMAD4_21799915_ChIP-Seq_A2780_Human1.03020840
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.02770489
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01126294
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00324244
74EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97951626
75RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97951626
76SOX9_26525672_Chip-Seq_HEART_Mouse0.97328985
77SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97182935
78EZH2_27294783_Chip-Seq_NPCs_Mouse0.97009386
79TCF4_22108803_ChIP-Seq_LS180_Human0.96577539
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95599583
81AR_25329375_ChIP-Seq_VCAP_Human0.95244828
82KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95007425
83NANOG_18555785_Chip-Seq_ESCs_Mouse0.94384266
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92662998
85LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92489047
86RNF2_27304074_Chip-Seq_NSC_Mouse0.91703960
87CDX2_22108803_ChIP-Seq_LS180_Human0.90977672
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90955492
89AR_21909140_ChIP-Seq_LNCAP_Human0.90250830
90TP53_18474530_ChIP-ChIP_U2OS_Human0.89436629
91SOX2_16153702_ChIP-ChIP_HESCs_Human0.89431607
92SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88959022
93STAT1_20625510_ChIP-Seq_HELA_Human0.88288279
94PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87916394
95ETS1_20019798_ChIP-Seq_JURKAT_Human0.87520829
96PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87502703
97E2F1_21310950_ChIP-Seq_MCF-7_Human0.87295130
98ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86059701
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84810658
100MYC_18555785_ChIP-Seq_MESCs_Mouse0.84687673

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.14066022
2MP0000569_abnormal_digit_pigmentation4.11869668
3MP0005646_abnormal_pituitary_gland4.02213815
4MP0004885_abnormal_endolymph3.35933958
5MP0002938_white_spotting2.96400446
6MP0002736_abnormal_nociception_after2.64041732
7MP0005670_abnormal_white_adipose2.56114543
8MP0003705_abnormal_hypodermis_morpholog2.40416468
9MP0002396_abnormal_hematopoietic_system2.39045028
10MP0003880_abnormal_central_pattern2.29386064
11MP0002095_abnormal_skin_pigmentation2.04652563
12MP0004036_abnormal_muscle_relaxation1.98438795
13MP0000371_diluted_coat_color1.98136299
14MP0005174_abnormal_tail_pigmentation1.93612266
15MP0000534_abnormal_ureter_morphology1.89238091
16MP0001968_abnormal_touch/_nociception1.87941131
17MP0004084_abnormal_cardiac_muscle1.85374179
18MP0000516_abnormal_urinary_system1.83343031
19MP0005367_renal/urinary_system_phenotyp1.83343031
20MP0000631_abnormal_neuroendocrine_gland1.68140418
21MP0002735_abnormal_chemical_nociception1.66730725
22MP0009053_abnormal_anal_canal1.64882273
23MP0003941_abnormal_skin_development1.63478434
24MP0003183_abnormal_peptide_metabolism1.62990435
25MP0005551_abnormal_eye_electrophysiolog1.61257469
26MP0008995_early_reproductive_senescence1.60606006
27MP0005360_urolithiasis1.58738849
28MP0001485_abnormal_pinna_reflex1.50874579
29MP0008775_abnormal_heart_ventricle1.48579632
30MP0003942_abnormal_urinary_system1.48166650
31MP0003890_abnormal_embryonic-extraembry1.47329798
32MP0003786_premature_aging1.44386403
33MP0006072_abnormal_retinal_apoptosis1.44054499
34MP0000013_abnormal_adipose_tissue1.42887298
35MP0005083_abnormal_biliary_tract1.42681726
36MP0003787_abnormal_imprinting1.42350133
37MP0003693_abnormal_embryo_hatching1.41052920
38MP0004147_increased_porphyrin_level1.38736094
39MP0004145_abnormal_muscle_electrophysio1.32993713
40MP0001486_abnormal_startle_reflex1.30206015
41MP0000747_muscle_weakness1.29164743
42MP0003111_abnormal_nucleus_morphology1.28985667
43MP0009780_abnormal_chondrocyte_physiolo1.28604563
44MP0008058_abnormal_DNA_repair1.22725499
45MP0010094_abnormal_chromosome_stability1.22067639
46MP0000049_abnormal_middle_ear1.19677457
47MP0000372_irregular_coat_pigmentation1.16953604
48MP0002269_muscular_atrophy1.13825459
49MP0000647_abnormal_sebaceous_gland1.09826196
50MP0000566_synostosis1.09019861
51MP0005423_abnormal_somatic_nervous1.08510388
52MP0005645_abnormal_hypothalamus_physiol1.08130699
53MP0002075_abnormal_coat/hair_pigmentati1.06319731
54MP0005076_abnormal_cell_differentiation1.05499768
55MP0002108_abnormal_muscle_morphology1.04873388
56MP0002069_abnormal_eating/drinking_beha1.03295224
57MP0001764_abnormal_homeostasis1.03261431
58MP0004215_abnormal_myocardial_fiber1.02588552
59MP0002089_abnormal_postnatal_growth/wei1.02076113
60MP0005248_abnormal_Harderian_gland0.99248348
61MP0010307_abnormal_tumor_latency0.95668911
62MP0000733_abnormal_muscle_development0.95471688
63MP0002751_abnormal_autonomic_nervous0.95390408
64MP0001661_extended_life_span0.94774096
65MP0000759_abnormal_skeletal_muscle0.93677199
66MP0002168_other_aberrant_phenotype0.92936676
67MP0005187_abnormal_penis_morphology0.92725061
68MP0002210_abnormal_sex_determination0.92557356
69MP0001849_ear_inflammation0.92389015
70MP0002160_abnormal_reproductive_system0.91907830
71MP0003755_abnormal_palate_morphology0.91384598
72MP0005253_abnormal_eye_physiology0.90882081
73MP0008872_abnormal_physiological_respon0.90797741
74MP0009250_abnormal_appendicular_skeleto0.90107587
75MP0000749_muscle_degeneration0.88580393
76MP0004133_heterotaxia0.87460036
77MP0003937_abnormal_limbs/digits/tail_de0.86960933
78MP0003943_abnormal_hepatobiliary_system0.86170966
79MP0001963_abnormal_hearing_physiology0.84787357
80MP0000653_abnormal_sex_gland0.84296413
81MP0005395_other_phenotype0.82013758
82MP0003718_maternal_effect0.80029130
83MP0005332_abnormal_amino_acid0.79070189
84MP0001727_abnormal_embryo_implantation0.76592025
85MP0008789_abnormal_olfactory_epithelium0.75772054
86MP0006292_abnormal_olfactory_placode0.73668486
87MP0003567_abnormal_fetal_cardiomyocyte0.73347868
88MP0000750_abnormal_muscle_regeneration0.73227004
89MP0001145_abnormal_male_reproductive0.73044347
90MP0003045_fibrosis0.71883454
91MP0005195_abnormal_posterior_eye0.71038289
92MP0001984_abnormal_olfaction0.69191249
93MP0000026_abnormal_inner_ear0.69133791
94MP0001186_pigmentation_phenotype0.67658810
95MP0005389_reproductive_system_phenotype0.65599458
96MP0009745_abnormal_behavioral_response0.65060427
97MP0002697_abnormal_eye_size0.63474418
98MP0005220_abnormal_exocrine_pancreas0.62487351
99MP0003121_genomic_imprinting0.62416371
100MP0001905_abnormal_dopamine_level0.62126785

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)5.80408743
2Hyperalaninemia (HP:0003348)5.80408743
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.80408743
4Abnormal hair whorl (HP:0010721)4.98080761
5Rectovaginal fistula (HP:0000143)4.83377027
6Rectal fistula (HP:0100590)4.83377027
7Septate vagina (HP:0001153)4.20376176
8Intestinal fistula (HP:0100819)4.17506174
9Congenital sensorineural hearing impairment (HP:0008527)3.99375880
10Esophageal varix (HP:0002040)3.97443140
11Vaginal fistula (HP:0004320)3.94694245
12Patchy hypopigmentation of hair (HP:0011365)3.90184962
13Abnormality of the fetal cardiovascular system (HP:0010948)3.88379417
14Abnormal umbilical cord blood vessels (HP:0011403)3.88379417
15Single umbilical artery (HP:0001195)3.88379417
16White forelock (HP:0002211)3.82257400
17Hyperlipoproteinemia (HP:0010980)3.78463793
18Constricted visual fields (HP:0001133)3.74640825
19Birth length less than 3rd percentile (HP:0003561)3.38589246
20Pigmentary retinal degeneration (HP:0001146)3.26727364
21Aplasia cutis congenita (HP:0001057)3.21799995
22Intestinal atresia (HP:0011100)3.20334916
23Skull defect (HP:0001362)3.10868584
24Palpebral edema (HP:0100540)3.02970340
25Abnormality of serum amino acid levels (HP:0003112)3.00630030
26Homocystinuria (HP:0002156)2.93296916
27Abnormality of homocysteine metabolism (HP:0010919)2.93296916
28Action tremor (HP:0002345)2.79525097
29Clitoromegaly (HP:0000057)2.68439856
30Midline defect of the nose (HP:0004122)2.67416142
31Anteriorly placed anus (HP:0001545)2.63056956
32Horizontal nystagmus (HP:0000666)2.58211293
33Megalencephaly (HP:0001355)2.57293332
34Absent phalangeal crease (HP:0006109)2.52094795
35Decreased electroretinogram (ERG) amplitude (HP:0000654)2.46242948
36Hyperglycinemia (HP:0002154)2.43314273
37Progressive cerebellar ataxia (HP:0002073)2.41141725
38Fair hair (HP:0002286)2.40952836
39Postural tremor (HP:0002174)2.38998734
403-Methylglutaconic aciduria (HP:0003535)2.37706131
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.34948972
42Ectopic anus (HP:0004397)2.30682834
43Gastrointestinal atresia (HP:0002589)2.29257500
44Abnormality of the nasolacrimal system (HP:0000614)2.26700710
45Pendular nystagmus (HP:0012043)2.23871063
46Generalized aminoaciduria (HP:0002909)2.22467490
47True hermaphroditism (HP:0010459)2.21134581
48Hypochromic microcytic anemia (HP:0004840)2.16075814
49Hypoproteinemia (HP:0003075)2.15974360
50Abnormal lung lobation (HP:0002101)2.15042357
51Chronic hepatic failure (HP:0100626)2.13053239
52Abnormal finger flexion creases (HP:0006143)2.10827448
53Round ear (HP:0100830)2.10666970
54Hyperventilation (HP:0002883)2.07151613
55Anal atresia (HP:0002023)2.05978194
56Chorioretinal atrophy (HP:0000533)2.05741483
57Anencephaly (HP:0002323)2.03802856
58Volvulus (HP:0002580)2.03768880
59Methylmalonic acidemia (HP:0002912)2.02264049
60Shawl scrotum (HP:0000049)2.01364723
61Cavernous hemangioma (HP:0001048)1.97023259
62Abnormality of sulfur amino acid metabolism (HP:0004339)1.96497574
63Abnormality of the phalanges of the hallux (HP:0010057)1.94955509
64Abnormality of the umbilical cord (HP:0010881)1.94376814
65Cortical visual impairment (HP:0100704)1.93656679
66Renal hypoplasia (HP:0000089)1.93358698
67Portal hypertension (HP:0001409)1.92982016
68Cutaneous finger syndactyly (HP:0010554)1.92163574
69Ectopic kidney (HP:0000086)1.91967742
70Myopathic facies (HP:0002058)1.88998640
71Glioma (HP:0009733)1.87666024
72Urethral obstruction (HP:0000796)1.84023613
73Occipital encephalocele (HP:0002085)1.84002890
74Vaginal atresia (HP:0000148)1.83562466
75Spontaneous hematomas (HP:0007420)1.81557481
76Renal dysplasia (HP:0000110)1.80718369
77Decreased subcutaneous fat (HP:0001002)1.80505984
78Genital tract atresia (HP:0001827)1.79953729
79Astrocytoma (HP:0009592)1.77417212
80Abnormality of the astrocytes (HP:0100707)1.77417212
81Abnormality of macular pigmentation (HP:0008002)1.77344149
82Toxemia of pregnancy (HP:0100603)1.74981095
83Abnormality of the clitoris (HP:0000056)1.73714484
84Pancreatic fibrosis (HP:0100732)1.73701216
85Abnormality of the hepatic vasculature (HP:0006707)1.73297866
86Methylmalonic aciduria (HP:0012120)1.72973302
87Esophageal atresia (HP:0002032)1.68638781
88Abnormality of the parathyroid morphology (HP:0011766)1.68100480
89Distal arthrogryposis (HP:0005684)1.67650258
90Medial flaring of the eyebrow (HP:0010747)1.64973478
91Cutaneous syndactyly (HP:0012725)1.64746356
92Nephronophthisis (HP:0000090)1.64544368
93Myocardial infarction (HP:0001658)1.63240956
94Generalized hypopigmentation of hair (HP:0011358)1.62225796
95Increased corneal curvature (HP:0100692)1.61850084
96Keratoconus (HP:0000563)1.61850084
97Bilateral microphthalmos (HP:0007633)1.61716588
98Rhabdomyosarcoma (HP:0002859)1.61504350
99Exocrine pancreatic insufficiency (HP:0001738)1.59702299
100Broad distal phalanx of finger (HP:0009836)1.59619549

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.28729353
2CCNB13.19816560
3PKN12.82738742
4FRK2.78186773
5EPHA32.74568378
6MAPK132.69007776
7BRSK22.59953192
8PHKG12.48054108
9PHKG22.48054108
10PIK3CA2.31021105
11JAK31.86224091
12SRPK11.83961787
13NTRK21.77848228
14OBSCN1.69358357
15TEC1.68190860
16RPS6KB21.58898825
17FGFR21.58271801
18STK241.56389031
19PAK31.53142717
20FER1.48629195
21MAP4K21.48572235
22FGR1.45905293
23PBK1.45696106
24MAP3K31.44613002
25BRSK11.29824278
26CDK91.29322168
27PLK31.26545964
28TTK1.25303248
29MST41.24154404
30SGK2231.22212215
31SGK4941.22212215
32NEK61.20818803
33DYRK21.15061981
34BCR1.13398641
35CAMK11.13237128
36GRK11.10552898
37CAMKK21.10133952
38MAP2K31.10081122
39NUAK11.08248218
40TIE11.05998306
41CHEK21.03592478
42SGK21.01738874
43VRK11.00914105
44CASK1.00836143
45IRAK10.99802868
46FGFR10.99462817
47OXSR10.95914781
48CAMK2G0.93737526
49DYRK30.93337934
50STK30.90993218
51PLK40.90506173
52CSNK1G10.88042751
53AURKA0.86596905
54LMTK20.86106769
55INSRR0.85299982
56PLK10.84562100
57PRKCI0.84339685
58ERBB20.84018239
59RPS6KB10.82774379
60DYRK1B0.80911649
61STK160.77007082
62ITK0.76893127
63TYRO30.75070304
64MKNK20.74480763
65MARK30.72939711
66TLK10.72798540
67FGFR30.67434472
68ADRBK10.64344408
69EPHB20.63418781
70WNK30.61640367
71ACVR1B0.58235311
72PRKCE0.57060015
73CDK30.55171461
74CDK50.53771886
75IRAK20.52538842
76CSNK1A10.51682038
77VRK20.51045198
78PTK60.50649421
79PRKCG0.48556882
80STK390.48293584
81ATR0.48267659
82CAMK2D0.45311367
83MAPK80.45178152
84CDK10.41913641
85EGFR0.41754531
86ATM0.41353469
87PRKACA0.41292225
88CAMK2B0.41277316
89PIK3CG0.39637543
90MAP2K70.38775641
91TESK20.38145125
92GSK3B0.37624840
93WNK40.36463476
94MINK10.35661411
95NTRK30.34575696
96ILK0.33701586
97STK40.33390807
98CDK70.33105296
99CSNK2A10.32947404
100WEE10.32452744

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006704.19188640
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.30341178
3Proteasome_Homo sapiens_hsa030502.69621186
4Arginine biosynthesis_Homo sapiens_hsa002202.64446542
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.60034384
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50655048
7Regulation of autophagy_Homo sapiens_hsa041402.38351081
8RNA polymerase_Homo sapiens_hsa030202.17373150
9Collecting duct acid secretion_Homo sapiens_hsa049662.04409584
10Oxidative phosphorylation_Homo sapiens_hsa001902.02456106
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98429447
12Folate biosynthesis_Homo sapiens_hsa007901.95937444
13Homologous recombination_Homo sapiens_hsa034401.86533969
14Cysteine and methionine metabolism_Homo sapiens_hsa002701.85093621
15Fanconi anemia pathway_Homo sapiens_hsa034601.84315679
16Ribosome_Homo sapiens_hsa030101.74703098
17Nicotine addiction_Homo sapiens_hsa050331.68511134
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67945314
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.67428068
20Morphine addiction_Homo sapiens_hsa050321.66080384
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.57326279
22Spliceosome_Homo sapiens_hsa030401.54152194
23Basal transcription factors_Homo sapiens_hsa030221.52350689
24Caffeine metabolism_Homo sapiens_hsa002321.50887022
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49457395
26RNA degradation_Homo sapiens_hsa030181.46789583
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44063416
28Selenocompound metabolism_Homo sapiens_hsa004501.40275193
29Vitamin digestion and absorption_Homo sapiens_hsa049771.39583911
30Sulfur relay system_Homo sapiens_hsa041221.39173056
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36756286
32Ether lipid metabolism_Homo sapiens_hsa005651.33656319
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32810038
34Sulfur metabolism_Homo sapiens_hsa009201.25909590
35Nitrogen metabolism_Homo sapiens_hsa009101.24607975
36Parkinsons disease_Homo sapiens_hsa050121.19655220
37GABAergic synapse_Homo sapiens_hsa047271.18261363
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.14312934
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10077946
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09155365
41Arginine and proline metabolism_Homo sapiens_hsa003301.03710166
42mRNA surveillance pathway_Homo sapiens_hsa030151.00461200
43RNA transport_Homo sapiens_hsa030130.99370172
44Phototransduction_Homo sapiens_hsa047440.98259297
45Circadian entrainment_Homo sapiens_hsa047130.98059811
46Biosynthesis of amino acids_Homo sapiens_hsa012300.97996836
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97413239
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96175200
49Retinol metabolism_Homo sapiens_hsa008300.94552191
50Purine metabolism_Homo sapiens_hsa002300.93604638
51Peroxisome_Homo sapiens_hsa041460.93430515
52Serotonergic synapse_Homo sapiens_hsa047260.89188448
53Olfactory transduction_Homo sapiens_hsa047400.87656678
54Huntingtons disease_Homo sapiens_hsa050160.87605328
55Tight junction_Homo sapiens_hsa045300.87169032
56Lysine degradation_Homo sapiens_hsa003100.85309744
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82979984
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81301190
59Cell cycle_Homo sapiens_hsa041100.80683924
60Tryptophan metabolism_Homo sapiens_hsa003800.76455229
61Oocyte meiosis_Homo sapiens_hsa041140.75373996
62Alzheimers disease_Homo sapiens_hsa050100.75230819
63Pyrimidine metabolism_Homo sapiens_hsa002400.73231205
64Cardiac muscle contraction_Homo sapiens_hsa042600.72525876
65ABC transporters_Homo sapiens_hsa020100.68759891
66Taste transduction_Homo sapiens_hsa047420.68701702
67Metabolic pathways_Homo sapiens_hsa011000.67356762
68Basal cell carcinoma_Homo sapiens_hsa052170.67038871
69Base excision repair_Homo sapiens_hsa034100.66823652
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66455263
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65966830
72Glutamatergic synapse_Homo sapiens_hsa047240.65485958
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64938427
74Dopaminergic synapse_Homo sapiens_hsa047280.63454746
75Linoleic acid metabolism_Homo sapiens_hsa005910.61651971
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61365089
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60274358
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59987169
79Glutathione metabolism_Homo sapiens_hsa004800.56191002
80Vibrio cholerae infection_Homo sapiens_hsa051100.56070477
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55193384
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54478903
83Galactose metabolism_Homo sapiens_hsa000520.52617848
84Protein export_Homo sapiens_hsa030600.52082765
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50887941
86Propanoate metabolism_Homo sapiens_hsa006400.50652603
87Calcium signaling pathway_Homo sapiens_hsa040200.50303628
88Cholinergic synapse_Homo sapiens_hsa047250.48449486
89Alcoholism_Homo sapiens_hsa050340.46147511
90Chemical carcinogenesis_Homo sapiens_hsa052040.44664672
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44346840
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42879616
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41166825
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41050088
95Mismatch repair_Homo sapiens_hsa034300.41010465
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40759181
97Hippo signaling pathway_Homo sapiens_hsa043900.40435990
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39399754
99Carbon metabolism_Homo sapiens_hsa012000.35549335
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35530735

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