HINT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine metabolic process (GO:0006558)6.53207323
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.53207323
3deoxyribonucleoside monophosphate metabolic process (GO:0009162)6.51285557
4L-phenylalanine catabolic process (GO:0006559)6.46248171
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.46248171
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.99490171
7aromatic amino acid family catabolic process (GO:0009074)5.75248818
8ATP synthesis coupled proton transport (GO:0015986)5.61263457
9energy coupled proton transport, down electrochemical gradient (GO:0015985)5.61263457
10glyoxylate metabolic process (GO:0046487)5.57452626
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.35564130
12respiratory electron transport chain (GO:0022904)5.17578349
13indole-containing compound catabolic process (GO:0042436)5.17261162
14indolalkylamine catabolic process (GO:0046218)5.17261162
15tryptophan catabolic process (GO:0006569)5.17261162
16electron transport chain (GO:0022900)5.07492749
17cysteine metabolic process (GO:0006534)5.01811008
18pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.00406088
19kynurenine metabolic process (GO:0070189)4.95654295
20lysine catabolic process (GO:0006554)4.95389144
21lysine metabolic process (GO:0006553)4.95389144
22sulfur amino acid catabolic process (GO:0000098)4.94836308
23protein complex biogenesis (GO:0070271)4.94172904
24chaperone-mediated protein transport (GO:0072321)4.92073341
25tryptophan metabolic process (GO:0006568)4.87700755
26triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.82017159
27bile acid biosynthetic process (GO:0006699)4.74676247
28establishment of protein localization to mitochondrial membrane (GO:0090151)4.67499816
29regulation of mitochondrial translation (GO:0070129)4.59239860
30serine family amino acid catabolic process (GO:0009071)4.52974663
31mitochondrial respiratory chain complex assembly (GO:0033108)4.47973472
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.46421692
33cellular ketone body metabolic process (GO:0046950)4.45951491
34amino-acid betaine metabolic process (GO:0006577)4.38979879
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.35034731
36mitochondrial respiratory chain complex I assembly (GO:0032981)4.35034731
37NADH dehydrogenase complex assembly (GO:0010257)4.35034731
38aromatic amino acid family metabolic process (GO:0009072)4.32158263
39deoxyribonucleotide catabolic process (GO:0009264)4.29472438
40deoxyribonucleoside triphosphate metabolic process (GO:0009200)4.29337147
41ribosomal small subunit biogenesis (GO:0042274)4.24614146
42short-chain fatty acid metabolic process (GO:0046459)4.24443014
43alpha-linolenic acid metabolic process (GO:0036109)4.22610054
44pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.17120359
45alpha-amino acid catabolic process (GO:1901606)4.15954732
46valine metabolic process (GO:0006573)4.15266435
47proteasome assembly (GO:0043248)4.14376214
48homocysteine metabolic process (GO:0050667)4.13031208
49fatty acid beta-oxidation (GO:0006635)4.12886419
50pyrimidine nucleotide catabolic process (GO:0006244)4.12097215
51urea metabolic process (GO:0019627)4.09637472
52urea cycle (GO:0000050)4.09637472
53protein maturation by protein folding (GO:0022417)4.09341319
54regulation of triglyceride catabolic process (GO:0010896)4.08875104
55branched-chain amino acid catabolic process (GO:0009083)4.05025698
56aldehyde catabolic process (GO:0046185)4.04062209
57deoxyribose phosphate catabolic process (GO:0046386)4.03970623
58high-density lipoprotein particle remodeling (GO:0034375)4.00010444
59cellular amino acid catabolic process (GO:0009063)3.97735330
602-deoxyribonucleotide biosynthetic process (GO:0009265)3.97276776
61deoxyribose phosphate biosynthetic process (GO:0046385)3.97276776
62ethanol oxidation (GO:0006069)3.94944066
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.94624740
642-oxoglutarate metabolic process (GO:0006103)3.93548062
65ribosomal small subunit assembly (GO:0000028)3.93008072
66bile acid metabolic process (GO:0008206)3.91959913
67fatty acid oxidation (GO:0019395)3.91829589
68nitrogen cycle metabolic process (GO:0071941)3.91429911
69regulation of cellular amino acid metabolic process (GO:0006521)3.90148753
70serine family amino acid metabolic process (GO:0009069)3.87897246
71branched-chain amino acid metabolic process (GO:0009081)3.87093391
72negative regulation of fibrinolysis (GO:0051918)3.85998442
73complement activation, alternative pathway (GO:0006957)3.85995181
74fatty acid catabolic process (GO:0009062)3.85387332
75ketone body metabolic process (GO:1902224)3.85219706
76lipid oxidation (GO:0034440)3.83638675
77purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.83032505
78purine deoxyribonucleotide catabolic process (GO:0009155)3.82507138
79urate metabolic process (GO:0046415)3.82281544
80drug transmembrane transport (GO:0006855)3.82101886
81regulation of protein activation cascade (GO:2000257)3.80780076
82DNA deamination (GO:0045006)3.80491727
83glycine metabolic process (GO:0006544)3.80265294
84monocarboxylic acid catabolic process (GO:0072329)3.78493828
85cytochrome complex assembly (GO:0017004)3.78455297
86coenzyme catabolic process (GO:0009109)3.78438069
87organic acid catabolic process (GO:0016054)3.76770379
88carboxylic acid catabolic process (GO:0046395)3.76770379
89protein carboxylation (GO:0018214)3.76753465
90peptidyl-glutamic acid carboxylation (GO:0017187)3.76753465
91viral transcription (GO:0019083)3.75442862
92tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.73145216
93RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.73145216
94tyrosine metabolic process (GO:0006570)3.71618949
95aspartate family amino acid catabolic process (GO:0009068)3.70698871
96regulation of cholesterol esterification (GO:0010872)3.70639805
97regulation of fibrinolysis (GO:0051917)3.70012562
98GDP-mannose metabolic process (GO:0019673)3.68559369
99carnitine metabolic process (GO:0009437)3.67393571
100acylglycerol homeostasis (GO:0055090)3.67315940
101triglyceride homeostasis (GO:0070328)3.67315940
102indolalkylamine metabolic process (GO:0006586)3.66366029
1032-deoxyribonucleotide metabolic process (GO:0009394)3.66249848
104protein targeting to mitochondrion (GO:0006626)3.66163160
105negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.65619293
106negative regulation of ligase activity (GO:0051352)3.65619293
107amine catabolic process (GO:0009310)3.65451286
108cellular biogenic amine catabolic process (GO:0042402)3.65451286
109base-excision repair, AP site formation (GO:0006285)3.65291347
110cellular modified amino acid catabolic process (GO:0042219)3.65279882
111acetyl-CoA metabolic process (GO:0006084)3.64502850
112serine family amino acid biosynthetic process (GO:0009070)3.64275047
113DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.63068405
114positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.61063042
115translational termination (GO:0006415)3.60983870
116benzene-containing compound metabolic process (GO:0042537)3.60655774
117negative regulation of sterol transport (GO:0032372)3.60396290
118negative regulation of cholesterol transport (GO:0032375)3.60396290
119regulation of complement activation (GO:0030449)3.57867443
120respiratory chain complex IV assembly (GO:0008535)3.56633679
121SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.56427636
122intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.51783345
123signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.51783345
124maturation of SSU-rRNA (GO:0030490)3.51121686
125cotranslational protein targeting to membrane (GO:0006613)3.50337790
126ATP biosynthetic process (GO:0006754)3.50034523
127deoxyribose phosphate metabolic process (GO:0019692)3.50028209
128protein targeting to ER (GO:0045047)3.49519627
129iron-sulfur cluster assembly (GO:0016226)3.48883207
130metallo-sulfur cluster assembly (GO:0031163)3.48883207
131signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.48139571
132signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.48139571
133signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.48139571
134protein-lipid complex remodeling (GO:0034368)3.47410793
135macromolecular complex remodeling (GO:0034367)3.47410793
136plasma lipoprotein particle remodeling (GO:0034369)3.47410793
137establishment of protein localization to mitochondrion (GO:0072655)3.47024182
138cellular glucuronidation (GO:0052695)3.46206063
139regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.46135095
140protein neddylation (GO:0045116)3.43276128
141protein localization to endoplasmic reticulum (GO:0070972)3.42600074
142drug transport (GO:0015893)3.42249115
143reverse cholesterol transport (GO:0043691)3.42225015
144signal transduction involved in DNA integrity checkpoint (GO:0072401)3.41233640
145signal transduction involved in DNA damage checkpoint (GO:0072422)3.41233640
146translational elongation (GO:0006414)3.38988215
147glutamate metabolic process (GO:0006536)3.38752400
148signal transduction involved in cell cycle checkpoint (GO:0072395)3.38160376
149flavonoid metabolic process (GO:0009812)3.37051825
150response to mercury ion (GO:0046689)3.35202469
151oxidative phosphorylation (GO:0006119)3.34165866
152imidazole-containing compound metabolic process (GO:0052803)3.34165724
153NAD biosynthetic process (GO:0009435)3.33420132
154purine nucleoside triphosphate biosynthetic process (GO:0009145)3.32452865
155cofactor catabolic process (GO:0051187)3.32419704
156protein localization to mitochondrion (GO:0070585)3.31950646
157purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.30446729
158establishment of protein localization to endoplasmic reticulum (GO:0072599)3.29699526
159nicotinamide nucleotide biosynthetic process (GO:0019359)3.29379874
160pyridine nucleotide biosynthetic process (GO:0019363)3.29379874
161response to nitrosative stress (GO:0051409)3.29362150
162drug catabolic process (GO:0042737)3.29234814
163phospholipid efflux (GO:0033700)3.29219765
164arginine metabolic process (GO:0006525)3.27970328
165blood coagulation, intrinsic pathway (GO:0007597)3.26582411
166purine deoxyribonucleotide metabolic process (GO:0009151)3.24917558
167plasma lipoprotein particle clearance (GO:0034381)3.23520486
168tricarboxylic acid metabolic process (GO:0072350)3.23360155
169anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.22914332
170oxaloacetate metabolic process (GO:0006107)3.22803268
171deoxyribonucleotide metabolic process (GO:0009262)3.22565762
172glucuronate metabolic process (GO:0019585)3.22543780
173uronic acid metabolic process (GO:0006063)3.22543780
174small molecule catabolic process (GO:0044282)3.22008728
175hydrogen ion transmembrane transport (GO:1902600)3.20171912
176aerobic respiration (GO:0009060)3.20053911
177antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.17015367
178translation (GO:0006412)3.16737458
179positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.15265404
180negative regulation of B cell apoptotic process (GO:0002903)3.14708451
181mitochondrial transport (GO:0006839)3.13576605
182transcription elongation from RNA polymerase III promoter (GO:0006385)3.13147106
183termination of RNA polymerase III transcription (GO:0006386)3.13147106
184pseudouridine synthesis (GO:0001522)3.08570953
185positive regulation of ligase activity (GO:0051351)3.06214056
186cellular component biogenesis (GO:0044085)3.05122572
187purine nucleotide salvage (GO:0032261)3.04135197
188viral life cycle (GO:0019058)3.01189077
189ribonucleoside triphosphate biosynthetic process (GO:0009201)2.99081905
190regulation of cellular amine metabolic process (GO:0033238)2.95622251
191telomere maintenance via semi-conservative replication (GO:0032201)2.95461513
192antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.94171753
193deoxyribonucleotide biosynthetic process (GO:0009263)2.87441992
194proton transport (GO:0015992)2.83666066
195guanosine-containing compound biosynthetic process (GO:1901070)2.82824654
196ubiquinone biosynthetic process (GO:0006744)2.81883416
197mannosylation (GO:0097502)2.81584546
198cellular protein complex disassembly (GO:0043624)2.80643976
199negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.80035341

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.08153549
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.15157369
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.86728032
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.39676695
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.00226718
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.43486680
7LXR_22158963_ChIP-Seq_LIVER_Mouse4.37131641
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.67355561
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.48514017
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.77766690
11E2F7_22180533_ChIP-Seq_HELA_Human2.64992454
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.41950395
13THAP11_20581084_ChIP-Seq_MESCs_Mouse2.40364698
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.36294336
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.19898120
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.97209272
17* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91943123
18ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.90575672
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.85547189
20SRF_21415370_ChIP-Seq_HL-1_Mouse1.83102900
21GATA1_22025678_ChIP-Seq_K562_Human1.82221298
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75607408
23MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72510173
24* GABP_17652178_ChIP-ChIP_JURKAT_Human1.64556440
25CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.63411618
26TTF2_22483619_ChIP-Seq_HELA_Human1.62777424
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.60275034
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59399494
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54704355
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51473197
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.47594649
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.47421329
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46961388
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46676101
35TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.45980583
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.43518765
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42356417
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.41395962
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.39623075
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39383683
41CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39098618
42KDM5A_27292631_Chip-Seq_BREAST_Human1.36438561
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.35778389
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.34365294
45ELF1_20517297_ChIP-Seq_JURKAT_Human1.33968038
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33508694
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32435707
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30780094
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29603795
50DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29048238
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27006076
52ELK1_19687146_ChIP-ChIP_HELA_Human1.26078268
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25451330
54FOXP1_21924763_ChIP-Seq_HESCs_Human1.25061566
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24242436
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23745773
57CIITA_25753668_ChIP-Seq_RAJI_Human1.22755499
58SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19348231
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18454882
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18003826
61NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15888061
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15292410
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13076916
64SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12192368
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11793687
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11554584
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10609506
68ZNF263_19887448_ChIP-Seq_K562_Human1.10078081
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09959521
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09301540
71DCP1A_22483619_ChIP-Seq_HELA_Human1.09016263
72P68_20966046_ChIP-Seq_HELA_Human1.08026171
73VDR_21846776_ChIP-Seq_THP-1_Human1.07327874
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06455614
75RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05648376
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05420709
77YY1_22570637_ChIP-Seq_MALME-3M_Human1.04720864
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04551814
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04274114
80CLOCK_20551151_ChIP-Seq_293T_Human1.03849729
81RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03416577
82MYC_18940864_ChIP-ChIP_HL60_Human1.03342143
83PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01691451
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00916140
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00440682
86MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99554364
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99308431
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98988732
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98936726
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97428560
91E2F1_20622854_ChIP-Seq_HELA_Human0.95879432
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93222009
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92653558
94SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92244656
95GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92047382
96TET1_21451524_ChIP-Seq_MESCs_Mouse0.91907320
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91800568
98TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91178643
99PHF8_20622854_ChIP-Seq_HELA_Human0.90860830
100MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90760383
101IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.89814700
102ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89444235
103PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89407803
104HNF4A_19822575_ChIP-Seq_HepG2_Human0.88650224
105BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.88051904
106* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87900080
107P300_27268052_Chip-Seq_Bcells_Human0.87344319
108FOXP3_21729870_ChIP-Seq_TREG_Human0.87045608
109GABP_19822575_ChIP-Seq_HepG2_Human0.86605215
110KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86233428
111XRN2_22483619_ChIP-Seq_HELA_Human0.86153257
112HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.86031931
113* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.84694084
114HTT_18923047_ChIP-ChIP_STHdh_Human0.84194819
115YY1_21170310_ChIP-Seq_MESCs_Mouse0.83752664
116VDR_23849224_ChIP-Seq_CD4+_Human0.82444318
117AR_20517297_ChIP-Seq_VCAP_Human0.81453920
118SCL_19346495_ChIP-Seq_HPC-7_Human0.80669794
119HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80083022
120SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79375794
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78710659
122CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.78073550
123RAD21_21589869_ChIP-Seq_MESCs_Mouse0.77550349
124CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77312648
125* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.76891532
126* BCL6_27268052_Chip-Seq_Bcells_Human0.76068244
127CTCF_26484167_Chip-Seq_Bcells_Mouse0.74938687
128LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.74442450
129RARB_24833708_ChIP-Seq_LIVER_Mouse0.74161615
130POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.73890080
131RARA_24833708_ChIP-Seq_LIVER_Mouse0.73089546
132GATA4_25053715_ChIP-Seq_YYC3_Human0.73060259
133NELFA_20434984_ChIP-Seq_ESCs_Mouse0.72417002
134PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72008535
135* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.71740323
136* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.70137528
137BCOR_27268052_Chip-Seq_Bcells_Human0.69873864
138TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.67974710
139HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.67723833
140KAP1_22055183_ChIP-Seq_ESCs_Mouse0.67220460
141LXR_22292898_ChIP-Seq_THP-1_Human0.66713301
142SOX2_18692474_ChIP-Seq_MEFs_Mouse0.66624174
143SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.65172622
144GATA2_22383799_ChIP-Seq_G1ME_Mouse0.63949414

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.09630600
2MP0005360_urolithiasis6.70650608
3MP0005085_abnormal_gallbladder_physiolo5.33837511
4MP0005365_abnormal_bile_salt5.22231314
5MP0008875_abnormal_xenobiotic_pharmacok4.48684556
6MP0003806_abnormal_nucleotide_metabolis4.37532073
7MP0003195_calcinosis3.24877892
8MP0005332_abnormal_amino_acid3.13801627
9MP0003252_abnormal_bile_duct3.07925093
10MP0010329_abnormal_lipoprotein_level3.00266229
11MP0000372_irregular_coat_pigmentation2.89016224
12MP0009840_abnormal_foam_cell2.84796403
13MP0005083_abnormal_biliary_tract2.59696116
14MP0001666_abnormal_nutrient_absorption2.42268080
15MP0003186_abnormal_redox_activity2.40489781
16MP0004019_abnormal_vitamin_homeostasis2.40359247
17MP0008058_abnormal_DNA_repair2.23886250
18MP0006036_abnormal_mitochondrial_physio2.15113890
19MP0003786_premature_aging2.14282352
20MP0001764_abnormal_homeostasis2.12110049
21MP0005319_abnormal_enzyme/_coenzyme2.06572090
22MP0002653_abnormal_ependyma_morphology2.04100681
23MP0003693_abnormal_embryo_hatching2.01679659
24MP0003191_abnormal_cellular_cholesterol1.99205038
25MP0002138_abnormal_hepatobiliary_system1.97535089
26MP0002163_abnormal_gland_morphology1.92791124
27MP0002118_abnormal_lipid_homeostasis1.91724350
28MP0009643_abnormal_urine_homeostasis1.90686496
29MP0000609_abnormal_liver_physiology1.88431807
30MP0001905_abnormal_dopamine_level1.79916561
31MP0002234_abnormal_pharynx_morphology1.79895050
32MP0005584_abnormal_enzyme/coenzyme_acti1.79764145
33MP0010094_abnormal_chromosome_stability1.70373567
34MP0005645_abnormal_hypothalamus_physiol1.68685305
35MP0008932_abnormal_embryonic_tissue1.64400072
36MP0008789_abnormal_olfactory_epithelium1.62678031
37MP0009697_abnormal_copulation1.61838573
38MP0003868_abnormal_feces_composition1.59281290
39MP0004957_abnormal_blastocyst_morpholog1.57108722
40MP0001727_abnormal_embryo_implantation1.57002215
41MP0005636_abnormal_mineral_homeostasis1.56828711
42MP0006072_abnormal_retinal_apoptosis1.55954463
43MP0005670_abnormal_white_adipose1.55609930
44MP0003011_delayed_dark_adaptation1.55460581
45MP0005379_endocrine/exocrine_gland_phen1.51498158
46MP0002837_dystrophic_cardiac_calcinosis1.49215477
47MP0009333_abnormal_splenocyte_physiolog1.47546526
48MP0002822_catalepsy1.46716548
49MP0010030_abnormal_orbit_morphology1.45590344
50MP0000358_abnormal_cell_content/1.44544498
51MP0005671_abnormal_response_to1.39412762
52MP0001529_abnormal_vocalization1.39306032
53MP0006292_abnormal_olfactory_placode1.31929316
54MP0003646_muscle_fatigue1.30782257
55MP0005451_abnormal_body_composition1.26179506
56MP0006035_abnormal_mitochondrial_morpho1.25629938
57MP0001919_abnormal_reproductive_system1.23749448
58MP0003656_abnormal_erythrocyte_physiolo1.23623969
59MP0005084_abnormal_gallbladder_morpholo1.23423115
60MP0004043_abnormal_pH_regulation1.19903794
61MP0002638_abnormal_pupillary_reflex1.19671250
62MP0003111_abnormal_nucleus_morphology1.19126139
63MP0000598_abnormal_liver_morphology1.15320902
64MP0001756_abnormal_urination1.13975375
65MP0005389_reproductive_system_phenotype1.12604105
66MP0002148_abnormal_hypersensitivity_rea1.12079051
67MP0003077_abnormal_cell_cycle1.10917658
68MP0008469_abnormal_protein_level1.10238639
69MP0009379_abnormal_foot_pigmentation1.09974561
70MP0004130_abnormal_muscle_cell1.06219213
71MP0008995_early_reproductive_senescence1.05975472
72MP0009764_decreased_sensitivity_to1.05949816
73MP0003724_increased_susceptibility_to1.04015037
74MP0005646_abnormal_pituitary_gland1.01513155
75MP0004145_abnormal_muscle_electrophysio1.01337254
76MP0004142_abnormal_muscle_tone0.99853757
77MP0005266_abnormal_metabolism0.99853511
78MP0005410_abnormal_fertilization0.99813294
79MP0003075_altered_response_to0.99236193
80MP0003123_paternal_imprinting0.99160281
81MP0002876_abnormal_thyroid_physiology0.99105189
82MP0009642_abnormal_blood_homeostasis0.98776721
83MP0009763_increased_sensitivity_to0.97294445
84MP0008007_abnormal_cellular_replicative0.96980894
85MP0005376_homeostasis/metabolism_phenot0.96325437
86MP0005330_cardiomyopathy0.96040507
87MP0002160_abnormal_reproductive_system0.94926201
88MP0002277_abnormal_respiratory_mucosa0.94098930
89MP0005535_abnormal_body_temperature0.90648663
90MP0005647_abnormal_sex_gland0.88391979
91MP0002078_abnormal_glucose_homeostasis0.87768558
92MP0001984_abnormal_olfaction0.87745007
93MP0005408_hypopigmentation0.87461816
94MP0003137_abnormal_impulse_conducting0.86294809
95MP0005499_abnormal_olfactory_system0.85986316
96MP0005394_taste/olfaction_phenotype0.85986316
97MP0002136_abnormal_kidney_physiology0.83727970
98MP0004147_increased_porphyrin_level0.81972630
99MP0005220_abnormal_exocrine_pancreas0.81892951
100MP0002210_abnormal_sex_determination0.80990247
101MP0002090_abnormal_vision0.79953607
102MP0002019_abnormal_tumor_incidence0.79837714
103MP0005253_abnormal_eye_physiology0.79500901
104MP0010368_abnormal_lymphatic_system0.79449639
105MP0005075_abnormal_melanosome_morpholog0.79215347
106MP0000639_abnormal_adrenal_gland0.79094712
107MP0001835_abnormal_antigen_presentation0.78846799
108MP0001145_abnormal_male_reproductive0.76373368
109MP0005666_abnormal_adipose_tissue0.75660694
110MP0000230_abnormal_systemic_arterial0.75488791
111MP0001765_abnormal_ion_homeostasis0.74782639
112MP0005058_abnormal_lysosome_morphology0.74684055
113MP0009765_abnormal_xenobiotic_induced0.74032833
114MP0002971_abnormal_brown_adipose0.73750472
115MP0001853_heart_inflammation0.73616968
116MP0000750_abnormal_muscle_regeneration0.73491783
117MP0001929_abnormal_gametogenesis0.72954969
118MP0000653_abnormal_sex_gland0.72532810
119MP0001881_abnormal_mammary_gland0.72507516
120MP0002938_white_spotting0.69513202
121MP0005334_abnormal_fat_pad0.69374273
122MP0003638_abnormal_response/metabolism_0.69250002
123MP0000749_muscle_degeneration0.63574574
124MP0005464_abnormal_platelet_physiology0.62151716
125MP0009785_altered_susceptibility_to0.59185333
126MP0004782_abnormal_surfactant_physiolog0.59009382
127MP0004084_abnormal_cardiac_muscle0.55205797
128MP0004215_abnormal_myocardial_fiber0.55197616
129MP0004036_abnormal_muscle_relaxation0.55190029
130MP0003221_abnormal_cardiomyocyte_apopto0.54578834
131MP0000343_altered_response_to0.54202169
132MP0002132_abnormal_respiratory_system0.53852733
133MP0003718_maternal_effect0.52539979
134MP0003953_abnormal_hormone_level0.51738512
135MP0002928_abnormal_bile_duct0.49853813
136MP0001661_extended_life_span0.49759432
137MP0005165_increased_susceptibility_to0.48563932
138MP0001845_abnormal_inflammatory_respons0.47809383
139MP0002269_muscular_atrophy0.47715226
140MP0005385_cardiovascular_system_phenoty0.46645048
141MP0001544_abnormal_cardiovascular_syste0.46645048
142MP0003436_decreased_susceptibility_to0.46238041
143MP0008872_abnormal_physiological_respon0.45632608
144MP0003959_abnormal_lean_body0.44462608
145MP0008873_increased_physiological_sensi0.43591727
146MP0002970_abnormal_white_adipose0.43145733
147MP0005448_abnormal_energy_balance0.42623851
148MP0000604_amyloidosis0.41696680
149MP0008775_abnormal_heart_ventricle0.41205959
150MP0005166_decreased_susceptibility_to0.40141285
151MP0002135_abnormal_kidney_morphology0.38176388
152MP0005025_abnormal_response_to0.37667667
153MP0005395_other_phenotype0.37054577
154MP0002332_abnormal_exercise_endurance0.35675700
155MP0002254_reproductive_system_inflammat0.35665252

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.17033849
2Intrahepatic cholestasis (HP:0001406)4.87798501
3Abnormality of monocarboxylic acid metabolism (HP:0010996)4.56778465
4Xanthomatosis (HP:0000991)4.44833707
5Hyperglycinuria (HP:0003108)4.42556434
6Hyperammonemia (HP:0001987)4.42031875
7Abnormality of fatty-acid metabolism (HP:0004359)4.39099773
8Hypoglycemic coma (HP:0001325)4.32023912
9Ketosis (HP:0001946)4.30809730
10Prolonged partial thromboplastin time (HP:0003645)4.28518180
11Deep venous thrombosis (HP:0002625)4.26090958
12Hypobetalipoproteinemia (HP:0003563)4.12659982
13Hyperlipoproteinemia (HP:0010980)4.06450214
14Generalized aminoaciduria (HP:0002909)4.03741027
15Abnormality of glycine metabolism (HP:0010895)3.99381009
16Abnormality of serine family amino acid metabolism (HP:0010894)3.99381009
17Hepatic necrosis (HP:0002605)3.88181526
18Abnormality of dicarboxylic acid metabolism (HP:0010995)3.87449955
19Dicarboxylic aciduria (HP:0003215)3.87449955
20Hyperglycinemia (HP:0002154)3.85858824
21Ketoacidosis (HP:0001993)3.80261685
22Cerebral edema (HP:0002181)3.68651048
23Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.67552971
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.61155381
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.44852812
26Acute encephalopathy (HP:0006846)3.43904487
27Lethargy (HP:0001254)3.37541886
28Delayed CNS myelination (HP:0002188)3.25086981
29Hepatocellular necrosis (HP:0001404)3.23425912
30Increased muscle lipid content (HP:0009058)3.21554259
31Proximal tubulopathy (HP:0000114)3.21043685
32Hypolipoproteinemia (HP:0010981)3.20471643
33Metabolic acidosis (HP:0001942)3.19662410
34Type I transferrin isoform profile (HP:0003642)3.16648022
35Joint hemorrhage (HP:0005261)3.10891969
36Abnormality of sulfur amino acid metabolism (HP:0004339)3.09296011
37Abnormality of serum amino acid levels (HP:0003112)3.06659603
38Complement deficiency (HP:0004431)3.06595551
39Glycosuria (HP:0003076)3.04260290
40Abnormality of urine glucose concentration (HP:0011016)3.04260290
41Abnormality of methionine metabolism (HP:0010901)3.03939860
42Abnormal mitochondria in muscle tissue (HP:0008316)3.02164581
43Gout (HP:0001997)3.01287790
44Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.99474473
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.95436947
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.95436947
47Hyperbilirubinemia (HP:0002904)2.94552762
48Increased intramyocellular lipid droplets (HP:0012240)2.90994740
49Acute necrotizing encephalopathy (HP:0006965)2.89845764
50Hypoalphalipoproteinemia (HP:0003233)2.88944483
51Lactic acidosis (HP:0003128)2.88039430
52Mitochondrial inheritance (HP:0001427)2.87733391
53Abnormality of the intrinsic pathway (HP:0010989)2.86139921
54Vomiting (HP:0002013)2.82002605
55Fat malabsorption (HP:0002630)2.81563627
56Abnormality of the common coagulation pathway (HP:0010990)2.80407818
57Exertional dyspnea (HP:0002875)2.77090327
58Lipid accumulation in hepatocytes (HP:0006561)2.74920068
59Increased CSF lactate (HP:0002490)2.72960065
60Abnormality of purine metabolism (HP:0004352)2.72671300
61Abnormality of nucleobase metabolism (HP:0010932)2.72590312
62Abnormality of pyrimidine metabolism (HP:0004353)2.72428335
63Nausea (HP:0002018)2.70616543
64Epidermoid cyst (HP:0200040)2.69871617
65Cerebral palsy (HP:0100021)2.67637048
66Abnormal protein glycosylation (HP:0012346)2.66766261
67Abnormal glycosylation (HP:0012345)2.66766261
68Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.66766261
69Abnormal protein N-linked glycosylation (HP:0012347)2.66766261
70Reticulocytopenia (HP:0001896)2.58340568
71Aplasia/Hypoplasia of the sacrum (HP:0008517)2.49225726
72Leukodystrophy (HP:0002415)2.46793468
73Progressive microcephaly (HP:0000253)2.45362227
74Optic disc pallor (HP:0000543)2.43566650
75Renal cortical cysts (HP:0000803)2.43348682
76Abnormality of cells of the erythroid lineage (HP:0012130)2.43178110
77Late onset (HP:0003584)2.43034740
78Increased serum lactate (HP:0002151)2.37227695
79Microretrognathia (HP:0000308)2.36699642
80Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.35017879
81Ragged-red muscle fibers (HP:0003200)2.34150378
82Aplastic anemia (HP:0001915)2.33566630
83Abnormality of renal resorption (HP:0011038)2.33299319
84Alkalosis (HP:0001948)2.32862227
85Respiratory difficulties (HP:0002880)2.32134845
86Myoglobinuria (HP:0002913)2.30251130
87Methylmalonic aciduria (HP:0012120)2.29903423
88Progressive macrocephaly (HP:0004481)2.28525757
89Conjugated hyperbilirubinemia (HP:0002908)2.27293599
90Macrocytic anemia (HP:0001972)2.27286664
91Hypercholesterolemia (HP:0003124)2.25649906
92Reduced antithrombin III activity (HP:0001976)2.24816258
93Emotional lability (HP:0000712)2.24058289
94Microvesicular hepatic steatosis (HP:0001414)2.23802396
95Hyperphosphaturia (HP:0003109)2.23466779
963-Methylglutaconic aciduria (HP:0003535)2.22414138
97Increased hepatocellular lipid droplets (HP:0006565)2.22207042
98Steatorrhea (HP:0002570)2.21846488
99Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.21146741
100Renal Fanconi syndrome (HP:0001994)2.20401753
101Increased purine levels (HP:0004368)2.20203328
102Hyperuricemia (HP:0002149)2.20203328
103Abnormal number of erythroid precursors (HP:0012131)2.18300985
104Abnormality of complement system (HP:0005339)2.18036442
105Pancreatitis (HP:0001733)2.18034088
106Pancytopenia (HP:0001876)2.13590975
107Rhabdomyolysis (HP:0003201)2.09600024
108Brushfield spots (HP:0001088)2.07719380
109Respiratory failure (HP:0002878)2.03336584
110Irritability (HP:0000737)2.03096454
111Vascular calcification (HP:0004934)2.02795204
112Hypoglycemic seizures (HP:0002173)2.02534122
113Opisthotonus (HP:0002179)2.01794398
114CNS demyelination (HP:0007305)1.99748540
115Testicular atrophy (HP:0000029)1.99331228
116Hyperthyroidism (HP:0000836)1.99065094
117Abnormality of glycolysis (HP:0004366)1.98878164
118Increased serum pyruvate (HP:0003542)1.98878164
119Muscle fiber atrophy (HP:0100295)1.98533697
120Neonatal onset (HP:0003623)1.97938545
121Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97201495
122Gliosis (HP:0002171)1.94634786
123Hepatocellular carcinoma (HP:0001402)1.93432432
124Palpitations (HP:0001962)1.92264734
125Spontaneous abortion (HP:0005268)1.90606789
126Elevated hepatic transaminases (HP:0002910)1.90467795
127Exercise intolerance (HP:0003546)1.90218703
128Hydroxyprolinuria (HP:0003080)1.89799511
129Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87124887
130Prolonged neonatal jaundice (HP:0006579)1.86227757
131X-linked dominant inheritance (HP:0001423)1.84314280
132Hypokinesia (HP:0002375)1.84226643
133Petechiae (HP:0000967)1.82320593
134Abnormality of the anterior horn cell (HP:0006802)1.80193991
135Degeneration of anterior horn cells (HP:0002398)1.80193991
136Congenital malformation of the right heart (HP:0011723)1.78335304
137Double outlet right ventricle (HP:0001719)1.78335304
138Multiple enchondromatosis (HP:0005701)1.77044797
139Progressive muscle weakness (HP:0003323)1.74729534
140Cleft eyelid (HP:0000625)1.70165003
141Type 2 muscle fiber atrophy (HP:0003554)1.67577197
142Medial flaring of the eyebrow (HP:0010747)1.65573485
143Hypertensive crisis (HP:0100735)1.64763430
144Agammaglobulinemia (HP:0004432)1.64732207
145Obstructive lung disease (HP:0006536)1.63360273
146Chronic obstructive pulmonary disease (HP:0006510)1.63360273
147Abnormal urine phosphate concentration (HP:0012599)1.62285557
148Absent thumb (HP:0009777)1.61010747
149Acute hepatic failure (HP:0006554)1.60908765
150Abnormal pupillary function (HP:0007686)1.60196288

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.35984446
2VRK26.59381331
3NME23.46619952
4TESK13.21683414
5ERN13.10257745
6BUB12.70352185
7STK162.67626640
8FLT32.64402288
9MYLK2.55990135
10LIMK12.28677668
11KDR2.25156515
12SCYL22.15914768
13FGFR42.06779007
14SIK11.99891614
15PINK11.96625670
16MUSK1.86888911
17WNK41.76705495
18DAPK11.74495793
19PKN21.73047769
20TIE11.70974931
21CSNK1G31.63548180
22CDC71.62730229
23WNK31.60733366
24TAF11.59704679
25TAOK31.57198100
26IRAK31.55113365
27MAP4K21.54348825
28SMG11.52828972
29INSRR1.50037450
30STK38L1.48888112
31ARAF1.48812484
32MST1R1.48384021
33ABL21.42402983
34MAP3K111.42220314
35NUAK11.40667047
36TYK21.36249652
37MAPK151.31160671
38PIK3CG1.31087902
39MAP2K61.28140344
40CSNK1A1L1.26001895
41TBK11.24923305
42AURKA1.23011986
43TRIB31.21592343
44MAP2K31.20209122
45TEC1.17774274
46CSNK1G21.17712795
47MST41.17417629
48CSNK1G11.16582198
49MAPK111.12859439
50SRPK11.12453041
51EIF2AK31.11844711
52TLK11.10528779
53NEK91.08923748
54DYRK21.06348854
55PRKG21.06068379
56KIT1.05978465
57EIF2AK11.02320054
58CDK81.00540252
59VRK10.98510020
60OBSCN0.98253832
61TGFBR20.97974033
62MAPKAPK30.97531046
63CCNB10.92195504
64DYRK30.90456193
65PDK40.90121796
66PDK30.90121796
67MAP3K120.89622607
68MAP2K20.87679468
69MAP3K70.87146004
70BTK0.86515719
71NEK10.86005355
72RPS6KA50.85446133
73MAP2K70.84038669
74MAPKAPK50.83339561
75PRKAA20.82805525
76GRK50.82673832
77MAPK40.81739524
78PLK10.80866864
79ZAP700.80658064
80PIM20.80530016
81NME10.80083132
82WEE10.77175308
83MAP4K10.76973877
84MAP3K30.75239986
85LMTK20.73221318
86LRRK20.72920918
87ILK0.72113010
88OXSR10.71736387
89MAP2K40.71712768
90JAK20.70725619
91AURKB0.69583909
92PIK3CA0.69345178
93IKBKE0.67845905
94IRAK10.66657150
95ATR0.66601636
96GRK10.66400494
97PBK0.63719759
98PHKG10.61449444
99PHKG20.61449444
100BRSK10.61181598
101PRKD30.60693524
102TGFBR10.59969090
103CAMK2G0.57810139
104CHEK20.56527863
105CSNK2A20.56324176
106ERBB40.54307323
107IRAK40.54049284
108CDK70.54019787
109ZAK0.53606145
110BRAF0.53361773
111TRIM280.53186734
112DYRK1B0.53158931
113PAK10.53100080
114GRK60.53024901
115RPS6KA40.52177217
116TAOK20.51423864
117PLK40.50707710
118CAMKK20.49356786
119MAPK120.48991025
120PRKCI0.48720548
121DAPK30.48583269
122RPS6KB20.47792827
123IKBKB0.46669763
124PLK30.44405838
125CDK190.43878502
126NLK0.43837711
127PRKACG0.43738000
128BLK0.42400733
129TNK20.39974665
130PRKAA10.39816220
131CAMK2D0.38812458
132CAMK10.37411781
133CSNK2A10.37341180
134ADRBK20.36390869
135EIF2AK20.36389343
136TESK20.36284559
137TTN0.35133776
138AKT20.34532942
139CDK40.34501556
140PRKCD0.34173481
141MATK0.33910399
142TNIK0.33790816
143CSF1R0.33753274
144IRAK20.32547583
145CDK140.32519460
146PDK20.32178604
147PTK60.31708614
148PRKCQ0.30563058
149PIM10.29333516
150PAK40.28769858
151CSNK1A10.27855100
152PRKCZ0.27647282
153SYK0.25252452
154CDK11A0.24420930
155BMPR1B0.23867805

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.46856442
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.94480690
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.87721741
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.77395717
5Fatty acid degradation_Homo sapiens_hsa000712.76657075
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.64797201
7Propanoate metabolism_Homo sapiens_hsa006402.61997567
8Tryptophan metabolism_Homo sapiens_hsa003802.40707831
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.33657094
10Arginine biosynthesis_Homo sapiens_hsa002202.29619588
11Peroxisome_Homo sapiens_hsa041462.28761332
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.27906079
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.26099062
14Butanoate metabolism_Homo sapiens_hsa006502.21501915
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.18730889
16Nitrogen metabolism_Homo sapiens_hsa009102.17363918
17Mismatch repair_Homo sapiens_hsa034302.15128548
18Base excision repair_Homo sapiens_hsa034102.12598646
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.96221044
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93117709
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90509746
22Fatty acid metabolism_Homo sapiens_hsa012121.89183888
23Homologous recombination_Homo sapiens_hsa034401.87553860
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.85402535
25Complement and coagulation cascades_Homo sapiens_hsa046101.84039743
26Pyruvate metabolism_Homo sapiens_hsa006201.80886307
27Folate biosynthesis_Homo sapiens_hsa007901.75008533
28Sulfur metabolism_Homo sapiens_hsa009201.73132998
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.70697268
30beta-Alanine metabolism_Homo sapiens_hsa004101.70233137
31PPAR signaling pathway_Homo sapiens_hsa033201.70134191
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.69393965
33Chemical carcinogenesis_Homo sapiens_hsa052041.69087886
34Carbon metabolism_Homo sapiens_hsa012001.66045907
35Oxidative phosphorylation_Homo sapiens_hsa001901.59525251
36Fatty acid elongation_Homo sapiens_hsa000621.57690663
37Histidine metabolism_Homo sapiens_hsa003401.56591618
38Selenocompound metabolism_Homo sapiens_hsa004501.50519449
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49271001
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.45446213
41Parkinsons disease_Homo sapiens_hsa050121.44736126
42Sulfur relay system_Homo sapiens_hsa041221.42007922
43Nucleotide excision repair_Homo sapiens_hsa034201.39994940
44Caffeine metabolism_Homo sapiens_hsa002321.39169989
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.38233595
46Phenylalanine metabolism_Homo sapiens_hsa003601.37491915
47Retinol metabolism_Homo sapiens_hsa008301.35161471
48Fanconi anemia pathway_Homo sapiens_hsa034601.32243651
49Biosynthesis of amino acids_Homo sapiens_hsa012301.30411613
50Starch and sucrose metabolism_Homo sapiens_hsa005001.26342562
51Tyrosine metabolism_Homo sapiens_hsa003501.23098490
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21149390
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19356934
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18567561
55Primary immunodeficiency_Homo sapiens_hsa053401.17644180
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15583119
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14709778
58Ribosome_Homo sapiens_hsa030101.13797921
59Cyanoamino acid metabolism_Homo sapiens_hsa004601.10439416
60Maturity onset diabetes of the young_Homo sapiens_hsa049501.06712171
61Arginine and proline metabolism_Homo sapiens_hsa003301.06068233
62Staphylococcus aureus infection_Homo sapiens_hsa051501.05271951
63Spliceosome_Homo sapiens_hsa030401.03369482
64Glutathione metabolism_Homo sapiens_hsa004801.02383714
65Bile secretion_Homo sapiens_hsa049761.01330167
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98639117
67Fat digestion and absorption_Homo sapiens_hsa049750.98469781
68Pentose phosphate pathway_Homo sapiens_hsa000300.87263093
69Alzheimers disease_Homo sapiens_hsa050100.86776605
70ABC transporters_Homo sapiens_hsa020100.85302099
71Asthma_Homo sapiens_hsa053100.83816137
72Huntingtons disease_Homo sapiens_hsa050160.82539683
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80209792
74Metabolic pathways_Homo sapiens_hsa011000.79586411
75Vitamin digestion and absorption_Homo sapiens_hsa049770.78670532
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78335800
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73884717
78Fructose and mannose metabolism_Homo sapiens_hsa000510.73744896
79Systemic lupus erythematosus_Homo sapiens_hsa053220.70950464
80Galactose metabolism_Homo sapiens_hsa000520.67481010
81Glycerolipid metabolism_Homo sapiens_hsa005610.66211844
82Autoimmune thyroid disease_Homo sapiens_hsa053200.64217130
83RNA degradation_Homo sapiens_hsa030180.64043333
84One carbon pool by folate_Homo sapiens_hsa006700.63065688
85Type I diabetes mellitus_Homo sapiens_hsa049400.62701261
86Proteasome_Homo sapiens_hsa030500.62158326
87Allograft rejection_Homo sapiens_hsa053300.61874707
88Graft-versus-host disease_Homo sapiens_hsa053320.58378919
89Protein export_Homo sapiens_hsa030600.57379740
90RNA transport_Homo sapiens_hsa030130.55777846
91Collecting duct acid secretion_Homo sapiens_hsa049660.55107754
92Antigen processing and presentation_Homo sapiens_hsa046120.54172814
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.50676895
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49485646
95Pyrimidine metabolism_Homo sapiens_hsa002400.49340421
96Steroid biosynthesis_Homo sapiens_hsa001000.48988360
97Lysine degradation_Homo sapiens_hsa003100.46837573
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43711806
99Non-homologous end-joining_Homo sapiens_hsa034500.41695786
100Cardiac muscle contraction_Homo sapiens_hsa042600.35350693
101Vibrio cholerae infection_Homo sapiens_hsa051100.34910923
102Vitamin B6 metabolism_Homo sapiens_hsa007500.33925805
103Phototransduction_Homo sapiens_hsa047440.31371965
104Rheumatoid arthritis_Homo sapiens_hsa053230.29467728
105Arachidonic acid metabolism_Homo sapiens_hsa005900.23679240
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22948488
107Linoleic acid metabolism_Homo sapiens_hsa005910.21280748
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.17351648
109Other glycan degradation_Homo sapiens_hsa005110.14462005
110Insulin resistance_Homo sapiens_hsa049310.11522009
111Fatty acid biosynthesis_Homo sapiens_hsa000610.09358642
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07942952
113RNA polymerase_Homo sapiens_hsa030200.07278660
114Purine metabolism_Homo sapiens_hsa002300.06312997
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.04433182
116DNA replication_Homo sapiens_hsa030300.02077980
117N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0629207
118AMPK signaling pathway_Homo sapiens_hsa04152-0.0541739
119Glucagon signaling pathway_Homo sapiens_hsa04922-0.0324467
120Prion diseases_Homo sapiens_hsa05020-0.0323661
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0305661
122Regulation of autophagy_Homo sapiens_hsa04140-0.0228945
123Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0206984
124Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0010869

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