HINT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histidine triad proteins, such as HINT3, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of somitogenesis (GO:0014807)7.84247515
2leukotriene biosynthetic process (GO:0019370)7.57934256
3sulfation (GO:0051923)6.40653327
4regulation of DNA damage checkpoint (GO:2000001)6.24256331
5replicative senescence (GO:0090399)5.36266593
6positive regulation of fatty acid beta-oxidation (GO:0032000)5.36135729
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.33013520
8L-phenylalanine catabolic process (GO:0006559)5.33013520
9viral mRNA export from host cell nucleus (GO:0046784)5.21379113
10L-phenylalanine metabolic process (GO:0006558)5.14751325
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.14751325
12leukotriene metabolic process (GO:0006691)5.06242304
13protein prenylation (GO:0018342)4.76871929
14prenylation (GO:0097354)4.76871929
15positive regulation of fatty acid oxidation (GO:0046321)4.74870641
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.55245488
17plasma membrane repair (GO:0001778)4.40665636
18fatty acid elongation (GO:0030497)4.33266859
19aromatic amino acid family catabolic process (GO:0009074)4.31921716
20negative regulation of systemic arterial blood pressure (GO:0003085)4.25019189
21positive regulation of RNA splicing (GO:0033120)4.19848540
22tooth mineralization (GO:0034505)4.16245684
23respiratory electron transport chain (GO:0022904)4.15931245
24purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.11190788
253-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.11190788
26activation of protein kinase A activity (GO:0034199)4.08482375
27electron transport chain (GO:0022900)4.04428004
28cholesterol biosynthetic process (GO:0006695)3.96918642
29cerebellar Purkinje cell differentiation (GO:0021702)3.94741989
30mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.92828873
31cellular ketone body metabolic process (GO:0046950)3.89806825
32peristalsis (GO:0030432)3.89214483
33sulfur amino acid catabolic process (GO:0000098)3.83956304
34ATP synthesis coupled proton transport (GO:0015986)3.83623838
35energy coupled proton transport, down electrochemical gradient (GO:0015985)3.83623838
36regulation of cell proliferation involved in kidney development (GO:1901722)3.83606101
37bundle of His cell to Purkinje myocyte communication (GO:0086069)3.82478399
38icosanoid biosynthetic process (GO:0046456)3.76238697
39fatty acid derivative biosynthetic process (GO:1901570)3.76238697
40regulation of fatty acid beta-oxidation (GO:0031998)3.75796117
41cell proliferation in forebrain (GO:0021846)3.72110868
42positive regulation of cardiac muscle cell differentiation (GO:2000727)3.71167297
43aldehyde catabolic process (GO:0046185)3.69860423
44cardiac muscle adaptation (GO:0014887)3.69635199
45cardiac muscle hypertrophy in response to stress (GO:0014898)3.69635199
46muscle hypertrophy in response to stress (GO:0003299)3.69635199
47glyoxylate metabolic process (GO:0046487)3.68338495
48detection of molecule of bacterial origin (GO:0032490)3.68043869
49positive regulation by symbiont of host defense response (GO:0052509)3.66894887
50modulation by symbiont of host defense response (GO:0052031)3.66894887
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.66894887
52modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.66894887
53positive regulation by organism of defense response of other organism involved in symbiotic interact3.66894887
54modulation by symbiont of host immune response (GO:0052553)3.66894887
55positive regulation of cAMP-mediated signaling (GO:0043950)3.63240254
56response to UV-C (GO:0010225)3.57865624
57microglial cell activation (GO:0001774)3.56282740
58sterol biosynthetic process (GO:0016126)3.53713826
59response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.53682511
60short-chain fatty acid metabolic process (GO:0046459)3.48589630
61regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.46264254
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.44952892
63positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.44929137
64heme transport (GO:0015886)3.44917362
65bile acid biosynthetic process (GO:0006699)3.43588901
66tryptophan catabolic process (GO:0006569)3.40100935
67indole-containing compound catabolic process (GO:0042436)3.40100935
68indolalkylamine catabolic process (GO:0046218)3.40100935
69cardiac muscle hypertrophy (GO:0003300)3.40013732
70cellular response to ATP (GO:0071318)3.38917489
71regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.36912707
72ketone body metabolic process (GO:1902224)3.36477633
73pharyngeal system development (GO:0060037)3.36400423
74response to inactivity (GO:0014854)3.35847769
75striated muscle adaptation (GO:0014888)3.34607467
76cysteine metabolic process (GO:0006534)3.33288048
77negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.33040724
78fatty acid beta-oxidation (GO:0006635)3.32634749
79hematopoietic stem cell proliferation (GO:0071425)3.31599905
80alpha-linolenic acid metabolic process (GO:0036109)3.31572880
81positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.31490921
82acetyl-CoA metabolic process (GO:0006084)3.30816046
83triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.30640510
84adult heart development (GO:0007512)3.29388910
85carbohydrate phosphorylation (GO:0046835)3.28270582
86regulation of skeletal muscle contraction (GO:0014819)3.27873987
87aromatic amino acid family metabolic process (GO:0009072)3.26880636
88regulation of triglyceride catabolic process (GO:0010896)3.26467335
89adrenergic receptor signaling pathway (GO:0071875)3.25499587
90fatty acid catabolic process (GO:0009062)3.25218924
91cofactor catabolic process (GO:0051187)3.24662793
92tryptophan metabolic process (GO:0006568)3.24361742
93unsaturated fatty acid biosynthetic process (GO:0006636)3.23824177
94otic vesicle formation (GO:0030916)3.22909956
95fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.21932380
96post-anal tail morphogenesis (GO:0036342)3.21900607
97striated muscle hypertrophy (GO:0014897)3.21415648
98epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.21235106
99positive regulation of digestive system process (GO:0060456)3.18818737
100coenzyme catabolic process (GO:0009109)3.17189266
101kynurenine metabolic process (GO:0070189)3.15536895
102behavioral response to nicotine (GO:0035095)3.14944511
103thioester metabolic process (GO:0035383)3.14735628
104acyl-CoA metabolic process (GO:0006637)3.14735628
105fatty acid oxidation (GO:0019395)3.14222421
106regulation of cholesterol esterification (GO:0010872)3.13408454
107lipid oxidation (GO:0034440)3.11114306
108bile acid metabolic process (GO:0008206)3.11069039
109negative regulation of multicellular organism growth (GO:0040015)3.10074061
110bile acid and bile salt transport (GO:0015721)3.08942656
111labyrinthine layer development (GO:0060711)3.07357745
112very long-chain fatty acid metabolic process (GO:0000038)3.07035865
113regulation of glomerulus development (GO:0090192)3.06857960
114oxidative phosphorylation (GO:0006119)3.06466651
115positive regulation of fatty acid metabolic process (GO:0045923)3.06410806
116monocarboxylic acid catabolic process (GO:0072329)3.04187124
117tyrosine metabolic process (GO:0006570)3.03983472
118branched-chain amino acid catabolic process (GO:0009083)3.02293583
119thioester biosynthetic process (GO:0035384)2.99844832
120acyl-CoA biosynthetic process (GO:0071616)2.99844832
121glucuronate metabolic process (GO:0019585)2.99831648
122uronic acid metabolic process (GO:0006063)2.99831648
123low-density lipoprotein particle remodeling (GO:0034374)2.99527290
124regulation of phospholipid biosynthetic process (GO:0071071)2.98004165
125musculoskeletal movement (GO:0050881)2.97369102
126multicellular organismal movement (GO:0050879)2.97369102
127creatine metabolic process (GO:0006600)2.96797288
128negative regulation of peptidyl-lysine acetylation (GO:2000757)2.95298124
129regulation of cholesterol metabolic process (GO:0090181)2.95024828
130fatty-acyl-CoA biosynthetic process (GO:0046949)2.94692056
131regulation of DNA endoreduplication (GO:0032875)2.94614402
132fatty-acyl-CoA metabolic process (GO:0035337)2.94608595
133histone-serine phosphorylation (GO:0035404)2.92465062
134cAMP biosynthetic process (GO:0006171)2.89837731
135muscle hypertrophy (GO:0014896)2.89453264
136flavonoid metabolic process (GO:0009812)2.88986677
137long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.87825608
138striated muscle atrophy (GO:0014891)2.86359791
139ethanol oxidation (GO:0006069)2.86315400
140organic acid catabolic process (GO:0016054)2.86251162
141carboxylic acid catabolic process (GO:0046395)2.86251162
142cellular glucuronidation (GO:0052695)2.85919190
143protein-lipid complex remodeling (GO:0034368)2.85862454
144macromolecular complex remodeling (GO:0034367)2.85862454
145plasma lipoprotein particle remodeling (GO:0034369)2.85862454
146molting cycle (GO:0042303)2.84429915
147hair cycle (GO:0042633)2.84429915
148alkaloid metabolic process (GO:0009820)2.82543912
149regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.81986987
150protein carboxylation (GO:0018214)2.81504643
151peptidyl-glutamic acid carboxylation (GO:0017187)2.81504643
152regulation of actin filament-based movement (GO:1903115)2.80293612
153positive regulation of systemic arterial blood pressure (GO:0003084)2.79651289
154alpha-amino acid catabolic process (GO:1901606)2.78972621
155regulation of sequestering of triglyceride (GO:0010889)2.78748786
156high-density lipoprotein particle remodeling (GO:0034375)2.78707307
157cellular biogenic amine catabolic process (GO:0042402)2.78519861
158amine catabolic process (GO:0009310)2.78519861
159glutathione derivative biosynthetic process (GO:1901687)2.78200523
160glutathione derivative metabolic process (GO:1901685)2.78200523
161ethanol metabolic process (GO:0006067)2.77718941
162release of cytochrome c from mitochondria (GO:0001836)2.77407053
163regulation of cardiac muscle cell contraction (GO:0086004)2.76278342
164positive regulation of prostaglandin secretion (GO:0032308)2.75793070
165pyrimidine-containing compound transmembrane transport (GO:0072531)2.75036347
166regulation of fatty acid oxidation (GO:0046320)2.74990195
167glutathione metabolic process (GO:0006749)2.74707103
168cellular amino acid catabolic process (GO:0009063)2.74669444
169positive regulation of cellular amine metabolic process (GO:0033240)2.73955543
170plasma lipoprotein particle clearance (GO:0034381)2.73822563
171positive regulation of lipoprotein lipase activity (GO:0051006)2.73359784
172positive regulation of triglyceride lipase activity (GO:0061365)2.73359784
173branched-chain amino acid metabolic process (GO:0009081)2.73093862
174regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.73015770
175signal peptide processing (GO:0006465)2.72985218
176positive regulation of cardiac muscle hypertrophy (GO:0010613)2.72162045
177positive regulation of muscle hypertrophy (GO:0014742)2.72162045
178homocysteine metabolic process (GO:0050667)2.71943304
179drug transmembrane transport (GO:0006855)2.71201957
180interkinetic nuclear migration (GO:0022027)2.70825795
181triglyceride homeostasis (GO:0070328)2.70326595
182acylglycerol homeostasis (GO:0055090)2.70326595
183cell differentiation in hindbrain (GO:0021533)2.69242672
184serine family amino acid catabolic process (GO:0009071)2.67326643
185amino-acid betaine metabolic process (GO:0006577)2.67184638
186positive regulation of gluconeogenesis (GO:0045722)2.66909509
187dorsal/ventral axis specification (GO:0009950)2.66299601
188membrane protein ectodomain proteolysis (GO:0006509)2.64202590
189phospholipid efflux (GO:0033700)2.63475216
190negative regulation of muscle contraction (GO:0045932)2.61402301
191positive regulation of myoblast differentiation (GO:0045663)2.60600833
192nitrogen cycle metabolic process (GO:0071941)2.60558789
193steroid biosynthetic process (GO:0006694)2.60095529
194urea cycle (GO:0000050)2.59749482
195urea metabolic process (GO:0019627)2.59749482
196ATP biosynthetic process (GO:0006754)2.59227775

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human7.71979822
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.90771958
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.21145020
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.66910632
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.35746874
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.35645783
7PPARA_22158963_ChIP-Seq_LIVER_Mouse4.22542306
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.98932501
9EZH2_22144423_ChIP-Seq_EOC_Human3.59548060
10LXR_22158963_ChIP-Seq_LIVER_Mouse3.56407807
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.15133604
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.05485703
13TP53_16413492_ChIP-PET_HCT116_Human2.91060511
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.88455003
15RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.62219392
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60512160
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.53676324
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.47805777
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.45218302
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.44622580
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.43770092
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34976365
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.24222000
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21631589
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16973184
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.14189929
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.13999432
28GABP_17652178_ChIP-ChIP_JURKAT_Human2.13188536
29HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.12112950
30AR_21572438_ChIP-Seq_LNCaP_Human2.07788536
31GBX2_23144817_ChIP-Seq_PC3_Human2.04423402
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.04196983
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.90790021
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89985501
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.87453799
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86819865
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85839551
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.85749867
39IGF1R_20145208_ChIP-Seq_DFB_Human1.84410946
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75989019
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.72134070
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.69926197
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.66766906
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.66766906
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.63664222
46PKCTHETA_26484144_Chip-Seq_BREAST_Human1.63414245
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.61978487
48* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.61845079
49* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55484385
50AHR_22903824_ChIP-Seq_MCF-7_Human1.55214949
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54975207
52ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.52552419
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.50929795
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50679245
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49936853
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.48175572
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46953401
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.46512293
59PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.46017857
60STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.45166593
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41265345
62SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40813612
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40805990
64IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38961192
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38406599
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38163999
67LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37205350
68SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35621648
69DROSHA_22980978_ChIP-Seq_HELA_Human1.33670273
70SCL_19346495_ChIP-Seq_HPC-7_Human1.32046302
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.31211695
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.30240054
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28194777
74TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28162892
75SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27313893
76SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26805425
77GATA1_22025678_ChIP-Seq_K562_Human1.24757997
78EST1_17652178_ChIP-ChIP_JURKAT_Human1.23604254
79MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23553079
80* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22235791
81GATA4_25053715_ChIP-Seq_YYC3_Human1.19607379
82TP53_20018659_ChIP-ChIP_R1E_Mouse1.18084184
83TP63_17297297_ChIP-ChIP_HaCaT_Human1.16199891
84RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16063154
85TDRD3_21172665_ChIP-Seq_MCF-7_Human1.15771510
86GF1_26923725_Chip-Seq_HPCs_Mouse1.15615035
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14041349
88VDR_22108803_ChIP-Seq_LS180_Human1.12695602
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12397523
90VDR_21846776_ChIP-Seq_THP-1_Human1.12116866
91HTT_18923047_ChIP-ChIP_STHdh_Human1.11931899
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10383006
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09383643
94* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05387603
95* SOX2_20726797_ChIP-Seq_SW620_Human1.04769496
96GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02584331
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02479567
98SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02277868
99GATA1_19941826_ChIP-Seq_K562_Human1.01420578
100* ETS1_20019798_ChIP-Seq_JURKAT_Human1.00991150
101* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00166649
102SMAD3_21741376_ChIP-Seq_EPCs_Human0.99333411
103GF1B_26923725_Chip-Seq_HPCs_Mouse0.99009965
104MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.98825749
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98711229
106RING1B_27294783_Chip-Seq_ESCs_Mouse0.97350474
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97011825
108SMAD4_21741376_ChIP-Seq_EPCs_Human0.96672771
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95810227
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95573022
111CBP_20019798_ChIP-Seq_JUKART_Human0.95552100
112IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95552100
113TP53_18474530_ChIP-ChIP_U2OS_Human0.95524404
114EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95143606
115TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.94751964
116RUNX_20019798_ChIP-Seq_JUKART_Human0.94546082
117Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93119560
118POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92868698
119RING1B_27294783_Chip-Seq_NPCs_Mouse0.91509509
120KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91465668
121KAP1_22055183_ChIP-Seq_ESCs_Mouse0.90769925
122* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89183759
123SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.89114867
124GATA2_19941826_ChIP-Seq_K562_Human0.88445104
125* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88293730
126* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88293730
127BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87983981
128EGR1_19032775_ChIP-ChIP_M12_Human0.87808332
129* ELK1_22589737_ChIP-Seq_MCF10A_Human0.87665613
130NANOG_20526341_ChIP-Seq_ESCs_Human0.87047211
131FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86939632
132NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.86253536
133VDR_24763502_ChIP-Seq_THP-1_Human0.85639963
134RNF2_27304074_Chip-Seq_NSC_Mouse0.84903421
135CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84881287
136E2F1_18555785_ChIP-Seq_MESCs_Mouse0.84544937
137KDM2B_26808549_Chip-Seq_REH_Human0.84465944
138STAT4_19710469_ChIP-ChIP_TH1__Mouse0.84446387
139FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84085784
140FOXO3_23340844_ChIP-Seq_DLD1_Human0.82679432
141FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.81743239
142BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81451766
143RAD21_21589869_ChIP-Seq_MESCs_Mouse0.81145811
144FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.80559216
145STAT3_23295773_ChIP-Seq_U87_Human0.80258128
146SMAD3_21741376_ChIP-Seq_HESCs_Human0.80015008
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79809427
148RUNX1_27514584_Chip-Seq_MCF-7_Human0.79423843
149IRF1_19129219_ChIP-ChIP_H3396_Human0.78934568
150IRF8_27001747_Chip-Seq_BMDM_Mouse0.78646416
151OCT1_27270436_Chip-Seq_PROSTATE_Human0.78576440
152ERG_20517297_ChIP-Seq_VCAP_Human0.78342446
153DCP1A_22483619_ChIP-Seq_HELA_Human0.77230293
154EP300_21415370_ChIP-Seq_HL-1_Mouse0.76480601
155PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75427261
156P63_26484246_Chip-Seq_KERATINOCYTES_Human0.75224699
157CTCF_26484167_Chip-Seq_Bcells_Mouse0.75175295
158GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75119522
159TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.74708645
160THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.74559057
161ZNF263_19887448_ChIP-Seq_K562_Human0.73999560
162AR_20517297_ChIP-Seq_VCAP_Human0.73823220
163TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.73822386
164PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73183149
165SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.73026883
166AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72817295
167E2F1_17053090_ChIP-ChIP_MCF-7_Human0.72733074
168TAF15_26573619_Chip-Seq_HEK293_Human0.72616602
169PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72433099
170VDR_23849224_ChIP-Seq_CD4+_Human0.72047970
171SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71997655
172SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71848226
173SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.71819048
174SRY_22984422_ChIP-ChIP_TESTIS_Rat0.71499950
175ERG_20887958_ChIP-Seq_HPC-7_Mouse0.71368357
176CDX2_19796622_ChIP-Seq_MESCs_Mouse0.71209531
177CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.71137522
178RARG_19884340_ChIP-ChIP_MEFs_Mouse0.70493250
179TRIM28_21343339_ChIP-Seq_HEK293_Human0.70044711
180FOXM1_26456572_ChIP-Seq_MCF-7_Human0.69188861
181RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.68944905
182FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.68927840
183PRDM14_20953172_ChIP-Seq_ESCs_Human0.68208474
184GATA3_24758297_ChIP-Seq_MCF-7_Human0.68185362
185* STAT1_20625510_ChIP-Seq_HELA_Human0.67644239
186SOX9_24532713_ChIP-Seq_HFSC_Mouse0.67322153
187SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.66938099
188CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.66723688
189EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.66193503
190SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.66133518
191PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.65856190
192CDX2_20551321_ChIP-Seq_CACO-2_Human0.65512673
193RXRA_24833708_ChIP-Seq_LIVER_Mouse0.65501065
194CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.65485835
195SOX2_21211035_ChIP-Seq_LN229_Gbm0.64933289

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology8.48940709
2MP0003183_abnormal_peptide_metabolism8.02928197
3MP0003806_abnormal_nucleotide_metabolis5.05641200
4MP0002139_abnormal_hepatobiliary_system5.03147419
5MP0005379_endocrine/exocrine_gland_phen5.02960555
6MP0005360_urolithiasis4.67862960
7MP0005085_abnormal_gallbladder_physiolo4.28186354
8MP0005365_abnormal_bile_salt3.80536453
9MP0000613_abnormal_salivary_gland3.53131017
10MP0008875_abnormal_xenobiotic_pharmacok3.34622298
11MP0003195_calcinosis3.26842098
12MP0002089_abnormal_postnatal_growth/wei2.69504513
13MP0009840_abnormal_foam_cell2.62459742
14MP0004145_abnormal_muscle_electrophysio2.56400926
15MP0002160_abnormal_reproductive_system2.50363036
16MP0005451_abnormal_body_composition2.47749616
17MP0003186_abnormal_redox_activity2.43060352
18MP0005332_abnormal_amino_acid2.36973261
19MP0005083_abnormal_biliary_tract2.28979639
20MP0004134_abnormal_chest_morphology2.25871040
21MP0000733_abnormal_muscle_development2.22224672
22MP0001666_abnormal_nutrient_absorption2.22080871
23MP0005220_abnormal_exocrine_pancreas2.19522963
24MP0006036_abnormal_mitochondrial_physio2.09251101
25MP0000750_abnormal_muscle_regeneration2.08983575
26MP0005171_absent_coat_pigmentation2.06568167
27MP0010329_abnormal_lipoprotein_level2.04903296
28MP0003252_abnormal_bile_duct2.00984293
29MP0002332_abnormal_exercise_endurance1.97946690
30MP0003191_abnormal_cellular_cholesterol1.96575547
31MP0003724_increased_susceptibility_to1.88944190
32MP0002118_abnormal_lipid_homeostasis1.86959670
33MP0003656_abnormal_erythrocyte_physiolo1.86010608
34MP0005058_abnormal_lysosome_morphology1.85977358
35MP0008872_abnormal_physiological_respon1.85348968
36MP0004043_abnormal_pH_regulation1.84896427
37MP0003221_abnormal_cardiomyocyte_apopto1.81078924
38MP0001764_abnormal_homeostasis1.75020769
39MP0009643_abnormal_urine_homeostasis1.74581713
40MP0005584_abnormal_enzyme/coenzyme_acti1.71227960
41MP0009379_abnormal_foot_pigmentation1.65402297
42MP0002138_abnormal_hepatobiliary_system1.62404248
43MP0001661_extended_life_span1.61702485
44MP0009785_altered_susceptibility_to1.61303762
45MP0003693_abnormal_embryo_hatching1.60034225
46MP0000609_abnormal_liver_physiology1.58276236
47MP0005319_abnormal_enzyme/_coenzyme1.56379399
48MP0000751_myopathy1.52857646
49MP0006082_CNS_inflammation1.51184631
50MP0005636_abnormal_mineral_homeostasis1.44989539
51MP0000569_abnormal_digit_pigmentation1.44690394
52MP0004019_abnormal_vitamin_homeostasis1.43635695
53MP0003868_abnormal_feces_composition1.43273838
54MP0000920_abnormal_myelination1.42839627
55MP0003959_abnormal_lean_body1.37604854
56MP0002837_dystrophic_cardiac_calcinosis1.36307805
57MP0000013_abnormal_adipose_tissue1.35782180
58MP0002928_abnormal_bile_duct1.32391404
59MP0004130_abnormal_muscle_cell1.30335475
60MP0002108_abnormal_muscle_morphology1.29849305
61MP0002876_abnormal_thyroid_physiology1.28733469
62MP0001835_abnormal_antigen_presentation1.28199138
63MP0002148_abnormal_hypersensitivity_rea1.28164163
64MP0000049_abnormal_middle_ear1.27529912
65MP0005389_reproductive_system_phenotype1.26545665
66MP0009250_abnormal_appendicular_skeleto1.25746961
67MP0008469_abnormal_protein_level1.25602650
68MP0002106_abnormal_muscle_physiology1.24764536
69MP0000371_diluted_coat_color1.23510608
70MP0005671_abnormal_response_to1.22145171
71MP0001485_abnormal_pinna_reflex1.21794174
72MP0004484_altered_response_of1.20324170
73MP0003646_muscle_fatigue1.20211684
74MP0000678_abnormal_parathyroid_gland1.15966013
75MP0004215_abnormal_myocardial_fiber1.15150066
76MP0000003_abnormal_adipose_tissue1.14268239
77MP0004270_analgesia1.14212339
78MP0005369_muscle_phenotype1.13861597
79MP0003690_abnormal_glial_cell1.12762893
80MP0004185_abnormal_adipocyte_glucose1.12666065
81MP0000163_abnormal_cartilage_morphology1.11719598
82MP0000747_muscle_weakness1.11114370
83MP0005025_abnormal_response_to1.10983199
84MP0000759_abnormal_skeletal_muscle1.08534119
85MP0005670_abnormal_white_adipose1.08529580
86MP0000685_abnormal_immune_system1.08304973
87MP0004087_abnormal_muscle_fiber1.07954929
88MP0001879_abnormal_lymphatic_vessel1.04103548
89MP0003436_decreased_susceptibility_to1.02634612
90MP0003950_abnormal_plasma_membrane1.01925903
91MP0009384_cardiac_valve_regurgitation1.01508305
92MP0005408_hypopigmentation1.01481214
93MP0009697_abnormal_copulation1.00571891
94MP0005387_immune_system_phenotype1.00165126
95MP0001790_abnormal_immune_system1.00165126
96MP0008260_abnormal_autophagy0.99682717
97MP0005375_adipose_tissue_phenotype0.98756154
98MP0005187_abnormal_penis_morphology0.98736286
99MP0005266_abnormal_metabolism0.98416414
100MP0005666_abnormal_adipose_tissue0.97249414
101MP0005620_abnormal_muscle_contractility0.96707058
102MP0006035_abnormal_mitochondrial_morpho0.96521353
103MP0009763_increased_sensitivity_to0.94833653
104MP0009764_decreased_sensitivity_to0.94263325
105MP0004147_increased_porphyrin_level0.94186315
106MP0002254_reproductive_system_inflammat0.93796039
107MP0005000_abnormal_immune_tolerance0.93737036
108MP0002249_abnormal_larynx_morphology0.91543964
109MP0004036_abnormal_muscle_relaxation0.91028962
110MP0005535_abnormal_body_temperature0.89787441
111MP0005084_abnormal_gallbladder_morpholo0.89609997
112MP0005385_cardiovascular_system_phenoty0.89144103
113MP0001544_abnormal_cardiovascular_syste0.89144103
114MP0002419_abnormal_innate_immunity0.89010275
115MP0005376_homeostasis/metabolism_phenot0.87833554
116MP0002971_abnormal_brown_adipose0.87427366
117MP0002078_abnormal_glucose_homeostasis0.86558747
118MP0002796_impaired_skin_barrier0.85848890
119MP0002735_abnormal_chemical_nociception0.84621575
120MP0005503_abnormal_tendon_morphology0.84535741
121MP0002932_abnormal_joint_morphology0.84523525
122MP0004381_abnormal_hair_follicle0.84051853
123MP0003136_yellow_coat_color0.83887374
124MP0001845_abnormal_inflammatory_respons0.82575265
125MP0001756_abnormal_urination0.81764496
126MP0000372_irregular_coat_pigmentation0.80996468
127MP0004782_abnormal_surfactant_physiolog0.80715581
128MP0002127_abnormal_cardiovascular_syste0.80304780
129MP0001968_abnormal_touch/_nociception0.80179265
130MP0009765_abnormal_xenobiotic_induced0.78983670
131MP0009115_abnormal_fat_cell0.78465767
132MP0009642_abnormal_blood_homeostasis0.77840797
133MP0000749_muscle_degeneration0.77151737
134MP0000230_abnormal_systemic_arterial0.77087142
135MP0005330_cardiomyopathy0.77004270
136MP0002009_preneoplasia0.76930205
137MP0005334_abnormal_fat_pad0.75521910
138MP0002733_abnormal_thermal_nociception0.75243298
139MP0002693_abnormal_pancreas_physiology0.74899276
140MP0001346_abnormal_lacrimal_gland0.74419461
141MP0001542_abnormal_bone_strength0.73853939
142MP0002877_abnormal_melanocyte_morpholog0.72816138
143MP0008057_abnormal_DNA_replication0.70865863
144MP0005423_abnormal_somatic_nervous0.70077460
145MP0005165_increased_susceptibility_to0.70035988
146MP0002723_abnormal_immune_serum0.69436660
147MP0002136_abnormal_kidney_physiology0.68873332
148MP0000598_abnormal_liver_morphology0.68552705
149MP0003011_delayed_dark_adaptation0.68015859
150MP0001440_abnormal_grooming_behavior0.67503289
151MP0001533_abnormal_skeleton_physiology0.66777150
152MP0002638_abnormal_pupillary_reflex0.66617506
153MP0008873_increased_physiological_sensi0.64404185
154MP0003075_altered_response_to0.64404163
155MP0000762_abnormal_tongue_morphology0.64205294
156MP0010155_abnormal_intestine_physiology0.64029210
157MP0002166_altered_tumor_susceptibility0.63780751
158MP0004510_myositis0.63769465
159MP0002295_abnormal_pulmonary_circulatio0.63592872
160MP0005275_abnormal_skin_tensile0.62746591
161MP0003718_maternal_effect0.62026562
162MP0002972_abnormal_cardiac_muscle0.61933961
163MP0009780_abnormal_chondrocyte_physiolo0.60568853
164MP0005551_abnormal_eye_electrophysiolog0.60181191
165MP0002114_abnormal_axial_skeleton0.59572904
166MP0002277_abnormal_respiratory_mucosa0.58756672
167MP0003879_abnormal_hair_cell0.55705797
168MP0000631_abnormal_neuroendocrine_gland0.55439447
169MP0001270_distended_abdomen0.54853667
170MP0003279_aneurysm0.54216501
171MP0006138_congestive_heart_failure0.53552867
172MP0002272_abnormal_nervous_system0.52075848
173MP0003638_abnormal_response/metabolism_0.51900235
174MP0000537_abnormal_urethra_morphology0.50723281
175MP0002075_abnormal_coat/hair_pigmentati0.49445126
176MP0000767_abnormal_smooth_muscle0.48795887
177MP0002116_abnormal_craniofacial_bone0.48508960
178MP0003937_abnormal_limbs/digits/tail_de0.48360836
179MP0000681_abnormal_thyroid_gland0.47008280
180MP0004085_abnormal_heartbeat0.46756920
181MP0002133_abnormal_respiratory_system0.46661873

Predicted human phenotypes

RankGene SetZ-score
1Carpal bone hypoplasia (HP:0001498)6.93423868
2Vertebral arch anomaly (HP:0008438)6.79902986
3Diastasis recti (HP:0001540)6.39868248
4J-shaped sella turcica (HP:0002680)6.38731020
5Anomalous pulmonary venous return (HP:0010772)5.43417095
6Deformed sella turcica (HP:0002681)5.40310165
7Aplasia/Hypoplasia involving the carpal bones (HP:0006502)5.36163539
8Broad ribs (HP:0000885)5.18428098
9Thoracolumbar scoliosis (HP:0002944)5.00890661
10Abnormality of aromatic amino acid family metabolism (HP:0004338)4.89399723
11Flat acetabular roof (HP:0003180)4.88346561
12Abnormality of the pulmonary veins (HP:0011718)4.85619532
13Genetic anticipation (HP:0003743)4.82181743
14Abnormality of glycolipid metabolism (HP:0010969)4.66379873
15Abnormality of liposaccharide metabolism (HP:0010968)4.66379873
16Abnormality of glycosphingolipid metabolism (HP:0004343)4.66379873
17Abnormality of the odontoid process (HP:0003310)4.54394741
18Acute necrotizing encephalopathy (HP:0006965)4.46404765
19Abnormality of the sella turcica (HP:0002679)4.37387408
20Oral leukoplakia (HP:0002745)4.33665331
21Abnormality of the lumbar spine (HP:0100712)4.29113723
22Acute encephalopathy (HP:0006846)4.28345631
23Intrahepatic cholestasis (HP:0001406)4.14412387
24Abnormal mitochondria in muscle tissue (HP:0008316)4.13778465
25Hepatic necrosis (HP:0002605)4.13582348
26Cerebral edema (HP:0002181)3.97513354
27Hypoglycemic coma (HP:0001325)3.94797385
28Broad alveolar ridges (HP:0000187)3.86716953
29Flared iliac wings (HP:0002869)3.81214315
30Hemiplegia (HP:0002301)3.78030589
31Mitochondrial inheritance (HP:0001427)3.76962119
32Aortic regurgitation (HP:0001659)3.76876523
33Dicarboxylic aciduria (HP:0003215)3.70169040
34Abnormality of dicarboxylic acid metabolism (HP:0010995)3.70169040
35Xanthomatosis (HP:0000991)3.69785742
36Hepatocellular necrosis (HP:0001404)3.67720763
37Progressive macrocephaly (HP:0004481)3.65741758
38Aplasia/Hypoplasia of the scapulae (HP:0006713)3.49780624
39Hypoplastic scapulae (HP:0000882)3.49780624
40Abnormality of monocarboxylic acid metabolism (HP:0010996)3.49537011
41Hypobetalipoproteinemia (HP:0003563)3.48877580
42Hyperlipoproteinemia (HP:0010980)3.45868846
43Thoracic kyphosis (HP:0002942)3.45469945
44Prolonged partial thromboplastin time (HP:0003645)3.39357321
45Abnormality of fatty-acid metabolism (HP:0004359)3.25575674
46Pathologic fracture (HP:0002756)3.22865725
47Increased CSF lactate (HP:0002490)3.20237446
48Lethargy (HP:0001254)3.14319296
49Beaking of vertebral bodies (HP:0004568)3.13472648
50Short phalanx of the thumb (HP:0009660)3.13073517
51Generalized aminoaciduria (HP:0002909)3.11597388
52Slow saccadic eye movements (HP:0000514)3.09767342
53Hyperammonemia (HP:0001987)3.07258526
54Visual hallucinations (HP:0002367)3.06790453
55Abnormality of methionine metabolism (HP:0010901)3.06033093
563-Methylglutaconic aciduria (HP:0003535)2.94430821
57Hypoplasia of the odontoid process (HP:0003311)2.93066355
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.90391170
59Hyperglycinemia (HP:0002154)2.86383074
60Lipid accumulation in hepatocytes (HP:0006561)2.85423871
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.84004482
62Cavernous hemangioma (HP:0001048)2.81156265
63Conjugated hyperbilirubinemia (HP:0002908)2.79562256
64Renal Fanconi syndrome (HP:0001994)2.79359026
65Abnormality of serine family amino acid metabolism (HP:0010894)2.79257244
66Abnormality of glycine metabolism (HP:0010895)2.79257244
67Impaired smooth pursuit (HP:0007772)2.76469766
68Thickened calvaria (HP:0002684)2.75687633
69Deep venous thrombosis (HP:0002625)2.75477735
70Recurrent bronchitis (HP:0002837)2.75111000
71Hypolipoproteinemia (HP:0010981)2.75005155
72Increased muscle lipid content (HP:0009058)2.73647618
73Ketosis (HP:0001946)2.73634222
74Hyperglycinuria (HP:0003108)2.69825415
75Lactic acidosis (HP:0003128)2.69627028
76Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.68334099
77Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.67813077
78Fat malabsorption (HP:0002630)2.67418690
79Methylmalonic aciduria (HP:0012120)2.65520136
80Ovoid vertebral bodies (HP:0003300)2.64377804
81Tongue fasciculations (HP:0001308)2.64028100
82Death in childhood (HP:0003819)2.63218404
83Neoplasm of the heart (HP:0100544)2.62311771
84Respiratory failure (HP:0002878)2.61804918
85Increased hepatocellular lipid droplets (HP:0006565)2.61379703
86Increased intramyocellular lipid droplets (HP:0012240)2.59794386
87Protuberant abdomen (HP:0001538)2.59628226
88Abnormality of urine glucose concentration (HP:0011016)2.57694159
89Glycosuria (HP:0003076)2.57694159
90Abnormality of the thoracic spine (HP:0100711)2.56608381
91Prominent occiput (HP:0000269)2.56279451
92Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.54022257
93Short 1st metacarpal (HP:0010034)2.54022257
94Vertebral fusion (HP:0002948)2.53638279
95Leukodystrophy (HP:0002415)2.51069507
96Muscle fibrillation (HP:0010546)2.50815452
97Methylmalonic acidemia (HP:0002912)2.49975607
98Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.48369706
99Short 4th metacarpal (HP:0010044)2.48369706
100Decreased activity of mitochondrial respiratory chain (HP:0008972)2.47157793
101Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.47157793
102Parakeratosis (HP:0001036)2.45695979
103Progressive cerebellar ataxia (HP:0002073)2.45163517
104Increased serum pyruvate (HP:0003542)2.44342657
105Abnormality of glycolysis (HP:0004366)2.44342657
106Ketoacidosis (HP:0001993)2.42821495
107Vomiting (HP:0002013)2.41664458
108Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.39421659
109Abnormality of glutamine family amino acid metabolism (HP:0010902)2.38899837
110Palpebral edema (HP:0100540)2.37130352
111Abnormality of sulfur amino acid metabolism (HP:0004339)2.36948679
112Hypoalphalipoproteinemia (HP:0003233)2.36515482
113Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.35144647
114Abnormality of ocular smooth pursuit (HP:0000617)2.31590099
115Urinary glycosaminoglycan excretion (HP:0003541)2.27043051
116Mucopolysacchariduria (HP:0008155)2.27043051
117Tinnitus (HP:0000360)2.25753248
118Metabolic acidosis (HP:0001942)2.25205416
119Congenital ichthyosiform erythroderma (HP:0007431)2.23380072
120Abnormality of the alveolar ridges (HP:0006477)2.22411768
121Abnormality of the intrinsic pathway (HP:0010989)2.22288324
122Abnormality of the wing of the ilium (HP:0011867)2.22026170
123Steatorrhea (HP:0002570)2.21623149
124Hypoglycemic seizures (HP:0002173)2.20404816
125Abnormal tarsal ossification (HP:0008369)2.19998425
126Abnormality of the intervertebral disk (HP:0005108)2.19611620
127CNS demyelination (HP:0007305)2.19078094
128Increased serum lactate (HP:0002151)2.19014513
129Wide intermamillary distance (HP:0006610)2.18771478
130Abnormality of the 1st metacarpal (HP:0010009)2.18636887
131Calf muscle hypertrophy (HP:0008981)2.18624762
132Spastic paraparesis (HP:0002313)2.16762307
133Abnormality of the parietal bone (HP:0002696)2.15567942
134Hyperinsulinemic hypoglycemia (HP:0000825)2.15402647
135Short femoral neck (HP:0100864)2.14501267
136Difficulty running (HP:0009046)2.12197909
137Abnormality of the humerus (HP:0003063)2.11858115
138Epidermoid cyst (HP:0200040)2.09804207
139Clumsiness (HP:0002312)2.07568436
140Hyperbilirubinemia (HP:0002904)2.07281658
141Exercise intolerance (HP:0003546)2.05864532
142Cerebral hemorrhage (HP:0001342)2.05674975
143Muscle hypertrophy of the lower extremities (HP:0008968)2.05455013
144Abnormality of the common coagulation pathway (HP:0010990)2.04890519
145Abnormality of the upper arm (HP:0001454)2.04639453
146Abnormality of serum amino acid levels (HP:0003112)2.04193439
147Unilateral renal agenesis (HP:0000122)2.03790761
148Joint hemorrhage (HP:0005261)2.02079689
149Hepatosplenomegaly (HP:0001433)2.01699156
150Symptomatic seizures (HP:0011145)2.01596458
151Optic disc pallor (HP:0000543)2.00810618
152Hamartoma of the eye (HP:0010568)2.00417981
153Nausea (HP:0002018)1.99789618
154Exertional dyspnea (HP:0002875)1.98837126
155Abnormality of renal resorption (HP:0011038)1.98624761
156Sensory axonal neuropathy (HP:0003390)1.97551018
157Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.96312059
158Neuroendocrine neoplasm (HP:0100634)1.96297220
159Renal cortical cysts (HP:0000803)1.94367096
160Abnormality of polysaccharide metabolism (HP:0011012)1.94267681
161Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94267681
162Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94267681
163Palpitations (HP:0001962)1.93250391
164Proximal tubulopathy (HP:0000114)1.92483581
165Conjunctival hamartoma (HP:0100780)1.91061872
166Hyperphosphaturia (HP:0003109)1.90952420
167Malnutrition (HP:0004395)1.89900251
168Vacuolated lymphocytes (HP:0001922)1.89530533
169Fibular aplasia (HP:0002990)1.88112535
170Myoglobinuria (HP:0002913)1.87760528
171Hyperkalemia (HP:0002153)1.86654739
172Abnormality of the 4th metacarpal (HP:0010012)1.86385751
173Severe global developmental delay (HP:0011344)1.84782957
174Abnormality of purine metabolism (HP:0004352)1.84356707
175Pancreatitis (HP:0001733)1.84224749
176Abnormality of vitamin metabolism (HP:0100508)1.83552958
177Skin pits (HP:0100276)1.83044329
178Abnormality of the renal collecting system (HP:0004742)1.81657698
179Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.80845289
180Pheochromocytoma (HP:0002666)1.80570192
181Hypercholesterolemia (HP:0003124)1.79817207
182Irritability (HP:0000737)1.79709742
183Macroglossia (HP:0000158)1.79434676
184Porencephaly (HP:0002132)1.79330497
185Hyporeflexia of lower limbs (HP:0002600)1.78872219
186Hoarse voice (HP:0001609)1.74189803
187Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.74011627
188Dysostosis multiplex (HP:0000943)1.73318002
189Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.72965166
190Diplopia (HP:0000651)1.68455865
191Abnormality of binocular vision (HP:0011514)1.68455865
192Concave nail (HP:0001598)1.66575918
193Spontaneous abortion (HP:0005268)1.65213293
194Agitation (HP:0000713)1.64538730
195Confusion (HP:0001289)1.63560658
196Aplasia/hypoplasia of the femur (HP:0005613)1.63022858
197Duplicated collecting system (HP:0000081)1.58037357
198Craniofacial hyperostosis (HP:0004493)1.56975421
199Megalocornea (HP:0000485)1.55986876
200Recurrent pneumonia (HP:0006532)1.54959269

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K74.13010923
2BCKDK3.89209891
3MAP2K43.70394288
4MAP3K43.69188952
5NME23.64602390
6MST43.32209087
7STK393.07768719
8MST1R2.84545878
9PBK2.75826307
10EPHB12.49907396
11WNK42.21232831
12MAP2K32.11764579
13PIK3CA2.09808560
14TRIB32.00509179
15MET1.99427766
16MAP2K21.99323996
17CAMKK21.98515150
18PIM21.89606348
19ARAF1.81028985
20INSRR1.71191641
21GRK61.70864685
22LIMK11.65488528
23NME11.61158998
24STK41.57841250
25TBK11.57618774
26IRAK11.57055693
27KDR1.52325295
28CAMK41.48959802
29TGFBR21.43850943
30OXSR11.42750206
31MAP3K141.41974390
32TYK21.40845731
33IRAK31.40026148
34ABL21.33161938
35CAMK1D1.32311392
36ERN11.31544569
37TTN1.30178580
38FGFR41.29299798
39PRKD21.28725256
40SGK21.28681898
41PIK3CG1.27434176
42BRAF1.26623841
43PRPF4B1.25437908
44EIF2AK11.25260552
45TEC1.23340913
46TAOK31.22707286
47PKN21.20843765
48OBSCN1.20589154
49ZAK1.18724140
50MAPK151.18694347
51RET1.18289606
52BLK1.17010599
53BCR1.15293750
54MAP3K61.14352640
55TESK21.13933551
56PHKG11.11977993
57PHKG21.11977993
58IRAK21.10705786
59IKBKE1.09828953
60EIF2AK31.09236539
61TESK11.08961792
62FRK1.07684450
63MUSK1.05297642
64TAF11.04467221
65CDK121.02304460
66PTK2B1.02069751
67CAMK2D1.01966134
68NEK91.00934105
69IRAK41.00233545
70PKN11.00067561
71MOS0.99638818
72ACVR1B0.98340229
73MAP3K20.97595308
74CAMK2G0.97117189
75HIPK20.96540967
76MYLK0.96032122
77AKT30.95414624
78CSK0.95138940
79MAPKAPK50.91511474
80MAP3K110.91470134
81SGK30.90729280
82GRK70.90009892
83CAMKK10.88118425
84SGK2230.84853491
85SGK4940.84853491
86FLT30.82174455
87VRK10.79474837
88PDK40.79161681
89PDK30.79161681
90PIM10.77148118
91PDK20.76973284
92PRKCQ0.74753255
93MAPK110.73925073
94GRK50.72418116
95ADRBK10.70302266
96MAPK120.70115956
97NLK0.69641186
98MAP3K30.69566236
99RPS6KA50.69072083
100PRKAA10.68279296
101PDPK10.67427994
102BMPR1B0.67129514
103PINK10.67106683
104STK38L0.66742842
105IKBKB0.66453877
106MAP2K60.66230197
107BMPR20.65623451
108JAK20.65501780
109ZAP700.65202976
110STK160.62638548
111CAMK2B0.62366785
112BRSK20.62297894
113DYRK20.61872083
114EPHA20.59767135
115TLK10.58941782
116DYRK30.57819200
117DDR20.57788544
118MAP3K70.57673082
119ERBB40.57529094
120CAMK1G0.57332424
121JAK10.56759428
122EPHA30.54684267
123DAPK30.54001183
124MAP2K10.53968038
125AURKA0.53895830
126RPS6KA60.51850803
127LCK0.49858277
128GRK10.49037173
129LYN0.48725483
130PRKG20.48710531
131PRKCD0.48345171
132STK240.48325179
133PRKCE0.47609279
134PRKD10.46478296
135ADRBK20.45995654
136FGR0.45320559
137MELK0.45247154
138SYK0.44869950
139WNK10.44505907
140JAK30.42796389
141MARK20.42370461
142ITK0.42023952
143MAP3K90.41844240
144DYRK1B0.41833332
145SGK10.41144018
146PDK10.41007907
147TIE10.40622778
148CSNK1G30.40600264
149MAP3K10.40380466
150PRKAA20.39428187
151AKT20.39146531
152NEK60.38840435
153PRKACG0.38477298
154CDK90.36985264
155LMTK20.36489183
156MAPK40.33174821
157MAP3K50.32979876
158RPS6KL10.31854540
159RPS6KC10.31854540
160ERBB20.31660956
161STK110.31115374
162SMG10.30530269
163STK100.28533991
164PRKCH0.26392904
165TRPM70.25119121
166CAMK10.23504002
167DAPK20.23466872
168YES10.23304115
169PRKCI0.22830962

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053224.85514180
2Alcoholism_Homo sapiens_hsa050343.13126552
3Sulfur metabolism_Homo sapiens_hsa009203.11851182
4Oxidative phosphorylation_Homo sapiens_hsa001902.87403985
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.68269280
6Fatty acid elongation_Homo sapiens_hsa000622.64653804
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.59770049
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.48290077
9Parkinsons disease_Homo sapiens_hsa050122.39471248
10Steroid biosynthesis_Homo sapiens_hsa001002.37944925
11Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.33830606
12Fatty acid degradation_Homo sapiens_hsa000712.28409991
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.23334514
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.18095219
15Propanoate metabolism_Homo sapiens_hsa006402.15262530
16Peroxisome_Homo sapiens_hsa041462.10071706
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.09260687
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.08383791
19Butanoate metabolism_Homo sapiens_hsa006502.07126440
20Protein export_Homo sapiens_hsa030602.04639652
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.99747978
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.98961937
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.98640743
24Dilated cardiomyopathy_Homo sapiens_hsa054141.95164705
25Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.94970278
26Folate biosynthesis_Homo sapiens_hsa007901.90879738
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.89010602
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.87576313
29Tryptophan metabolism_Homo sapiens_hsa003801.84398948
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.78458105
31Alzheimers disease_Homo sapiens_hsa050101.78343328
32Renin secretion_Homo sapiens_hsa049241.72203614
33Fatty acid metabolism_Homo sapiens_hsa012121.69883387
34Histidine metabolism_Homo sapiens_hsa003401.66790783
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.65452278
36Viral carcinogenesis_Homo sapiens_hsa052031.64951513
37Taste transduction_Homo sapiens_hsa047421.64543935
38Chemical carcinogenesis_Homo sapiens_hsa052041.62452135
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.57357048
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.55341505
41Nitrogen metabolism_Homo sapiens_hsa009101.53374566
42Ovarian steroidogenesis_Homo sapiens_hsa049131.48726552
43GnRH signaling pathway_Homo sapiens_hsa049121.48161046
44Adipocytokine signaling pathway_Homo sapiens_hsa049201.46426091
45Calcium signaling pathway_Homo sapiens_hsa040201.45577248
46PPAR signaling pathway_Homo sapiens_hsa033201.44900105
47Type II diabetes mellitus_Homo sapiens_hsa049301.44624955
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42624234
49Huntingtons disease_Homo sapiens_hsa050161.42428211
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.42299445
51Arginine biosynthesis_Homo sapiens_hsa002201.39784255
52Melanoma_Homo sapiens_hsa052181.39447281
53Morphine addiction_Homo sapiens_hsa050321.38919887
54Proteasome_Homo sapiens_hsa030501.38356721
55Steroid hormone biosynthesis_Homo sapiens_hsa001401.38030666
56Pyruvate metabolism_Homo sapiens_hsa006201.35267833
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34115448
58Linoleic acid metabolism_Homo sapiens_hsa005911.33517039
59Gap junction_Homo sapiens_hsa045401.30514025
60Cholinergic synapse_Homo sapiens_hsa047251.28997315
61Fat digestion and absorption_Homo sapiens_hsa049751.27208631
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26935912
63Caffeine metabolism_Homo sapiens_hsa002321.25637562
64Longevity regulating pathway - mammal_Homo sapiens_hsa042111.23554721
65Ribosome_Homo sapiens_hsa030101.22857253
66Complement and coagulation cascades_Homo sapiens_hsa046101.22628345
67Glutamatergic synapse_Homo sapiens_hsa047241.19837370
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17410897
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16405699
70Sulfur relay system_Homo sapiens_hsa041221.14567333
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13906107
72Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13803963
73Glutathione metabolism_Homo sapiens_hsa004801.13731705
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13337834
75Basal cell carcinoma_Homo sapiens_hsa052171.12843144
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12790467
77Retinol metabolism_Homo sapiens_hsa008301.12645068
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12436237
79beta-Alanine metabolism_Homo sapiens_hsa004101.12233934
80Vitamin B6 metabolism_Homo sapiens_hsa007501.10863784
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10535094
82Tyrosine metabolism_Homo sapiens_hsa003501.09448869
83cAMP signaling pathway_Homo sapiens_hsa040241.09245895
84Carbon metabolism_Homo sapiens_hsa012001.08877004
85Drug metabolism - other enzymes_Homo sapiens_hsa009831.05646098
86Dorso-ventral axis formation_Homo sapiens_hsa043201.05023784
87FoxO signaling pathway_Homo sapiens_hsa040681.02592215
88Salivary secretion_Homo sapiens_hsa049701.02577320
89MAPK signaling pathway_Homo sapiens_hsa040101.01277242
90Phenylalanine metabolism_Homo sapiens_hsa003601.01167602
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99008107
92Hedgehog signaling pathway_Homo sapiens_hsa043400.98891220
93Selenocompound metabolism_Homo sapiens_hsa004500.98849220
94Nicotine addiction_Homo sapiens_hsa050330.97900137
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97883328
96Osteoclast differentiation_Homo sapiens_hsa043800.97717525
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97715780
98Insulin resistance_Homo sapiens_hsa049310.97647028
99Platelet activation_Homo sapiens_hsa046110.97402709
100GABAergic synapse_Homo sapiens_hsa047270.96474656
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95064841
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94057381
103Oxytocin signaling pathway_Homo sapiens_hsa049210.94056661
104Arginine and proline metabolism_Homo sapiens_hsa003300.93840736
105Insulin secretion_Homo sapiens_hsa049110.93087149
106ABC transporters_Homo sapiens_hsa020100.91126241
107Ether lipid metabolism_Homo sapiens_hsa005650.90293700
108B cell receptor signaling pathway_Homo sapiens_hsa046620.89301080
109Metabolic pathways_Homo sapiens_hsa011000.88796637
110Glioma_Homo sapiens_hsa052140.88732933
111T cell receptor signaling pathway_Homo sapiens_hsa046600.88554740
112Starch and sucrose metabolism_Homo sapiens_hsa005000.88458436
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.88404918
114Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86555584
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86395661
116Gastric acid secretion_Homo sapiens_hsa049710.85402662
117Glucagon signaling pathway_Homo sapiens_hsa049220.85036302
118Renin-angiotensin system_Homo sapiens_hsa046140.82463761
119Wnt signaling pathway_Homo sapiens_hsa043100.82101568
120Cardiac muscle contraction_Homo sapiens_hsa042600.82081107
121Melanogenesis_Homo sapiens_hsa049160.80163430
122Staphylococcus aureus infection_Homo sapiens_hsa051500.80011369
123Non-small cell lung cancer_Homo sapiens_hsa052230.78205485
124Circadian entrainment_Homo sapiens_hsa047130.76345167
125Pentose phosphate pathway_Homo sapiens_hsa000300.76204331
1262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75110887
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74090452
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74018578
129ErbB signaling pathway_Homo sapiens_hsa040120.72972787
130Arachidonic acid metabolism_Homo sapiens_hsa005900.72719740
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.72651064
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71705276
133Glycerolipid metabolism_Homo sapiens_hsa005610.70849515
134Estrogen signaling pathway_Homo sapiens_hsa049150.68856558
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66491431
136Amphetamine addiction_Homo sapiens_hsa050310.65925490
137MicroRNAs in cancer_Homo sapiens_hsa052060.64999281
138Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64539232
139Bile secretion_Homo sapiens_hsa049760.64190788
140Vitamin digestion and absorption_Homo sapiens_hsa049770.63571222
141Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63291741
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.62438325
143TNF signaling pathway_Homo sapiens_hsa046680.60656269
144Tuberculosis_Homo sapiens_hsa051520.60107009
145Long-term potentiation_Homo sapiens_hsa047200.60068050
146VEGF signaling pathway_Homo sapiens_hsa043700.60062711
147Circadian rhythm_Homo sapiens_hsa047100.58713949
148Prostate cancer_Homo sapiens_hsa052150.58537987
149Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57756497
150Prolactin signaling pathway_Homo sapiens_hsa049170.57608734
151AMPK signaling pathway_Homo sapiens_hsa041520.57094031
152Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56170984
153Sphingolipid metabolism_Homo sapiens_hsa006000.55424299
154Homologous recombination_Homo sapiens_hsa034400.55198742
155Regulation of autophagy_Homo sapiens_hsa041400.54736592
156Choline metabolism in cancer_Homo sapiens_hsa052310.53736070
157Bladder cancer_Homo sapiens_hsa052190.51872887
158mTOR signaling pathway_Homo sapiens_hsa041500.50493768
159RNA polymerase_Homo sapiens_hsa030200.49983359
160HTLV-I infection_Homo sapiens_hsa051660.49397675
161Pathways in cancer_Homo sapiens_hsa052000.46445275
162Leishmaniasis_Homo sapiens_hsa051400.45874256
163Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44539702
164Insulin signaling pathway_Homo sapiens_hsa049100.43019902
165Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42172128
166Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42158826
167Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41981817
168Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41922386
169Renal cell carcinoma_Homo sapiens_hsa052110.41458252
170Hepatitis C_Homo sapiens_hsa051600.41457913
171Glycerophospholipid metabolism_Homo sapiens_hsa005640.41269538
172Biosynthesis of amino acids_Homo sapiens_hsa012300.41209365
173Oocyte meiosis_Homo sapiens_hsa041140.39844738
174Neurotrophin signaling pathway_Homo sapiens_hsa047220.39537641
175Fructose and mannose metabolism_Homo sapiens_hsa000510.37418507
176Allograft rejection_Homo sapiens_hsa053300.35455290
177Galactose metabolism_Homo sapiens_hsa000520.33362306
178Graft-versus-host disease_Homo sapiens_hsa053320.32923900
179SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32770461
180Lysosome_Homo sapiens_hsa041420.31048499
181Mineral absorption_Homo sapiens_hsa049780.28985112
182Intestinal immune network for IgA production_Homo sapiens_hsa046720.27728349
183Cyanoamino acid metabolism_Homo sapiens_hsa004600.23712251
184Pyrimidine metabolism_Homo sapiens_hsa002400.21965117
185Fatty acid biosynthesis_Homo sapiens_hsa000610.21281167
186Other glycan degradation_Homo sapiens_hsa005110.18731936
187Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.10888947
188Autoimmune thyroid disease_Homo sapiens_hsa053200.09991368
189Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.09470107
190Rheumatoid arthritis_Homo sapiens_hsa053230.07811351

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