HIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.56814684
2presynaptic membrane organization (GO:0097090)4.89707076
3postsynaptic membrane organization (GO:0001941)4.69409809
4regulation of gene silencing by RNA (GO:0060966)4.69258933
5regulation of posttranscriptional gene silencing (GO:0060147)4.69258933
6regulation of gene silencing by miRNA (GO:0060964)4.69258933
7pre-miRNA processing (GO:0031054)4.69045042
8negative regulation of translation, ncRNA-mediated (GO:0040033)4.58427857
9regulation of translation, ncRNA-mediated (GO:0045974)4.58427857
10negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.58427857
11convergent extension (GO:0060026)3.99662568
12notochord development (GO:0030903)3.75624817
13neuron cell-cell adhesion (GO:0007158)3.64263171
14paraxial mesoderm development (GO:0048339)3.61802817
15axon extension involved in axon guidance (GO:0048846)3.52809686
16neuron projection extension involved in neuron projection guidance (GO:1902284)3.52809686
17hippo signaling (GO:0035329)3.50383908
18heterochromatin organization (GO:0070828)3.30484743
19establishment of nucleus localization (GO:0040023)3.28472827
20dermatan sulfate biosynthetic process (GO:0030208)3.28291869
21pyrimidine nucleobase catabolic process (GO:0006208)3.27143674
22mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.24748781
23glomerular filtration (GO:0003094)3.23313298
24semaphorin-plexin signaling pathway (GO:0071526)3.18087415
25dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.16107392
26plasma membrane repair (GO:0001778)3.16060468
27positive regulation of catenin import into nucleus (GO:0035413)3.12152926
28regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.11238524
29Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.10719282
30regulation of cell fate specification (GO:0042659)3.10244806
31vascular endothelial growth factor signaling pathway (GO:0038084)3.06863279
32vocalization behavior (GO:0071625)3.05831466
33protein-DNA complex disassembly (GO:0032986)3.04495637
34nucleosome disassembly (GO:0006337)3.04495637
35nuclear pore complex assembly (GO:0051292)3.00931946
36L-serine metabolic process (GO:0006563)2.97842656
37renal filtration (GO:0097205)2.96978147
38regulation of establishment of planar polarity (GO:0090175)2.96578724
39glomerular basement membrane development (GO:0032836)2.95967958
40dermatan sulfate metabolic process (GO:0030205)2.95375212
41axonal fasciculation (GO:0007413)2.93847959
42camera-type eye morphogenesis (GO:0048593)2.93596995
43basement membrane organization (GO:0071711)2.93394272
44retina vasculature morphogenesis in camera-type eye (GO:0061299)2.91658296
45neuron recognition (GO:0008038)2.90841979
46regulation of non-canonical Wnt signaling pathway (GO:2000050)2.87392295
47regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.85252264
48positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.82559777
49insulin-like growth factor receptor signaling pathway (GO:0048009)2.80322853
50regulation of hippo signaling (GO:0035330)2.78801971
51cell adhesion mediated by integrin (GO:0033627)2.78679326
52layer formation in cerebral cortex (GO:0021819)2.78321958
53regulation of catenin import into nucleus (GO:0035412)2.77902127
54neural tube closure (GO:0001843)2.77853082
55olfactory bulb development (GO:0021772)2.76492667
56planar cell polarity pathway involved in neural tube closure (GO:0090179)2.76430871
57limb development (GO:0060173)2.74991086
58appendage development (GO:0048736)2.74991086
59negative regulation of smooth muscle cell migration (GO:0014912)2.74871116
60non-canonical Wnt signaling pathway (GO:0035567)2.74293640
61tube closure (GO:0060606)2.74154159
62G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.73393338
63spinal cord development (GO:0021510)2.73386710
64glomerular visceral epithelial cell development (GO:0072015)2.73100243
65dorsal/ventral axis specification (GO:0009950)2.73008570
66apoptotic cell clearance (GO:0043277)2.71900469
67regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.68515407
68regulation of SMAD protein import into nucleus (GO:0060390)2.68467218
69regulation of stem cell maintenance (GO:2000036)2.68285249
70stress fiber assembly (GO:0043149)2.68166328
71somatic stem cell division (GO:0048103)2.67209261
72negative regulation of histone methylation (GO:0031061)2.66330891
73cytoskeletal anchoring at plasma membrane (GO:0007016)2.65732709
74central nervous system myelination (GO:0022010)2.65048157
75axon ensheathment in central nervous system (GO:0032291)2.65048157
76neural tube development (GO:0021915)2.64593954
77DNA unwinding involved in DNA replication (GO:0006268)2.63921749
78regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.63464008
79mesenchymal to epithelial transition (GO:0060231)2.62889032
80branching involved in salivary gland morphogenesis (GO:0060445)2.61528006
81regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.60481260
82regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.60022963
83L-amino acid import (GO:0043092)2.58903378
84heart morphogenesis (GO:0003007)2.58489058
85generation of neurons (GO:0048699)2.58084063
86cardiac myofibril assembly (GO:0055003)2.57231045
87forebrain development (GO:0030900)2.57161951
88nuclear pore organization (GO:0006999)2.56941347
89positive regulation of SMAD protein import into nucleus (GO:0060391)2.52825622
90polarized epithelial cell differentiation (GO:0030859)2.52408234
91negative regulation of catenin import into nucleus (GO:0035414)2.51819161
92regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.51696626
93chondroitin sulfate biosynthetic process (GO:0030206)2.51534416
94lung-associated mesenchyme development (GO:0060484)2.49755261
95cellular response to cholesterol (GO:0071397)2.49652917
96regulation of axon extension involved in axon guidance (GO:0048841)2.48403268
97amino acid import (GO:0043090)2.47522261
98membrane assembly (GO:0071709)2.47477474
99establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.46513891
100apical protein localization (GO:0045176)2.45884087
101chromatin silencing (GO:0006342)2.45244110
102nucleus localization (GO:0051647)2.45111077
103glomerular epithelial cell development (GO:0072310)2.44996516
104positive regulation of neuroblast proliferation (GO:0002052)2.44815843
105cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.44415282
106lymphangiogenesis (GO:0001946)2.43790894
107cortical actin cytoskeleton organization (GO:0030866)2.43435178
108NLS-bearing protein import into nucleus (GO:0006607)2.43060002
109protein complex localization (GO:0031503)2.42534599
110cranial nerve development (GO:0021545)2.42024607
111locomotory exploration behavior (GO:0035641)2.40830835
112limb bud formation (GO:0060174)2.40669330
113cerebral cortex radially oriented cell migration (GO:0021799)2.39690623
114outer ear morphogenesis (GO:0042473)2.38412311
115regulation of DNA methylation (GO:0044030)2.37973060
116digestive tract morphogenesis (GO:0048546)2.37825825
117lens fiber cell development (GO:0070307)2.37137267
118cytoplasmic mRNA processing body assembly (GO:0033962)2.36351708
119establishment of integrated proviral latency (GO:0075713)2.35853753
120regulation of axon guidance (GO:1902667)2.35553599
121embryonic retina morphogenesis in camera-type eye (GO:0060059)2.35121323
122somatic stem cell maintenance (GO:0035019)2.34843869
123DNA topological change (GO:0006265)2.34163186
124ectodermal placode formation (GO:0060788)2.33460362
125protein localization to kinetochore (GO:0034501)2.32797607
126coronary vasculature morphogenesis (GO:0060977)2.31751243
127kidney morphogenesis (GO:0060993)2.31656532
128cell proliferation in forebrain (GO:0021846)2.31255722
129substrate adhesion-dependent cell spreading (GO:0034446)2.31238904
130myoblast fusion (GO:0007520)2.30364375
131adherens junction assembly (GO:0034333)2.30269511
132cell migration in hindbrain (GO:0021535)2.30238621
133axon extension (GO:0048675)2.29517034
134thalamus development (GO:0021794)2.29107082
135midbrain development (GO:0030901)2.28699548
136chondroitin sulfate catabolic process (GO:0030207)2.28283847
137endodermal cell differentiation (GO:0035987)2.27262723
138protein localization to endosome (GO:0036010)2.25699585
139regulation of NFAT protein import into nucleus (GO:0051532)2.25122129
140ganglion development (GO:0061548)2.24791703
141myelination in peripheral nervous system (GO:0022011)2.24789066
142peripheral nervous system axon ensheathment (GO:0032292)2.24789066
143Notch signaling involved in heart development (GO:0061314)2.24670342
144lymph vessel development (GO:0001945)2.23346196
145syncytium formation by plasma membrane fusion (GO:0000768)2.22614685
146negative regulation of smoothened signaling pathway (GO:0045879)2.22304601
147regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.21937448
148protein heterotrimerization (GO:0070208)2.21885879
149aorta morphogenesis (GO:0035909)2.21721787
150heparan sulfate proteoglycan metabolic process (GO:0030201)2.21331531
151dendrite morphogenesis (GO:0048813)2.20256516
152glial cell proliferation (GO:0014009)2.18706173
153negative regulation of chondrocyte differentiation (GO:0032331)2.18670825
154collecting duct development (GO:0072044)2.18492884
155response to fluid shear stress (GO:0034405)2.18372261
156negative regulation of axon extension involved in axon guidance (GO:0048843)2.17827880
157cell surface receptor signaling pathway involved in heart development (GO:0061311)2.17445393
158cortical cytoskeleton organization (GO:0030865)2.14277755
159innervation (GO:0060384)2.14126568
160wound healing, spreading of epidermal cells (GO:0035313)2.14108352
161morphogenesis of an epithelial sheet (GO:0002011)2.14067756
162positive regulation of macrophage cytokine production (GO:0060907)2.14061673
163lateral sprouting from an epithelium (GO:0060601)2.13379686
164positive regulation of axon extension (GO:0045773)2.13171148
165regulation of synapse structural plasticity (GO:0051823)2.10969261
166syncytium formation (GO:0006949)2.10898776
167response to lipoprotein particle (GO:0055094)2.10742296
168morphogenesis of an endothelium (GO:0003159)2.10647273
169endothelial tube morphogenesis (GO:0061154)2.10647273
170heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.10012143
171neuron projection extension (GO:1990138)2.08459713
172cell migration involved in sprouting angiogenesis (GO:0002042)2.07308637
173endothelial cell morphogenesis (GO:0001886)2.06900189
174substrate-dependent cell migration (GO:0006929)2.06200475
175cochlea morphogenesis (GO:0090103)2.05778506
176adherens junction organization (GO:0034332)2.05504590
177neuronal stem cell maintenance (GO:0097150)2.05235405
178positive regulation of oligodendrocyte differentiation (GO:0048714)2.05232996

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.43304138
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.30952473
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.78853242
4EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.75331858
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.62490149
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.44027003
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.29063872
8WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.24288848
9SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.20075843
10POU5F1_16153702_ChIP-ChIP_HESCs_Human2.11477626
11TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.06951597
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.06774111
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.06710372
14EZH2_22144423_ChIP-Seq_EOC_Human1.99919627
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.95480142
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93626591
17ZFP281_18757296_ChIP-ChIP_E14_Mouse1.90757087
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87873206
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.86801914
20DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.85635794
21* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84050221
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83838298
23SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.81907089
24CLOCK_20551151_ChIP-Seq_293T_Human1.80829029
25GATA1_26923725_Chip-Seq_HPCs_Mouse1.79551670
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.76721675
27POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.76566466
28TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76566466
29* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76209309
30GBX2_23144817_ChIP-Seq_PC3_Human1.75544781
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74790955
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74790955
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.72492347
34ZFP281_27345836_Chip-Seq_ESCs_Mouse1.72152816
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70575238
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70059907
37STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.69116764
38KDM2B_26808549_Chip-Seq_K562_Human1.68254453
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68036343
40SOX2_16153702_ChIP-ChIP_HESCs_Human1.65346151
41RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.64271188
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60061938
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58868145
44TBX3_20139965_ChIP-Seq_ESCs_Mouse1.58161651
45TBX3_20139965_ChIP-Seq_MESCs_Mouse1.57776446
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.56979942
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56529700
48TCF3_18692474_ChIP-Seq_MESCs_Mouse1.56485580
49DROSHA_22980978_ChIP-Seq_HELA_Human1.54844067
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.53818979
51ISL1_27105846_Chip-Seq_CPCs_Mouse1.53599022
52POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.53246865
53NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.50723936
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49851681
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49004055
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.48928981
57* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.48484835
58* KDM2B_26808549_Chip-Seq_DND41_Human1.48100376
59ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.47978541
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47584098
61POU5F1_16518401_ChIP-PET_MESCs_Mouse1.46507388
62SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46447958
63* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46414168
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.46338067
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.46081152
66SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43415866
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40891791
68* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.39936513
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.39867624
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38879604
71JARID2_20064375_ChIP-Seq_MESCs_Mouse1.36217801
72PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.35699772
73TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35673321
74BRD4_25478319_ChIP-Seq_HGPS_Human1.35057116
75TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.34836938
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34648859
77TP53_16413492_ChIP-PET_HCT116_Human1.34598674
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34242170
79RNF2_27304074_Chip-Seq_ESCs_Mouse1.34218112
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.34178228
81AHR_22903824_ChIP-Seq_MCF-7_Human1.33575115
82EZH2_27304074_Chip-Seq_ESCs_Mouse1.31149382
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.29892230
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.28134429
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27007643
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.26898282
87NANOG_16153702_ChIP-ChIP_HESCs_Human1.26764952
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.24856299
89TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.24820234
90SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24791532
91AR_21572438_ChIP-Seq_LNCaP_Human1.22941643
92SOX9_26525672_Chip-Seq_HEART_Mouse1.22229831
93NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20693315
94REST_21632747_ChIP-Seq_MESCs_Mouse1.20608521
95SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20424286
96FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18415938
97TBX20_22080862_ChIP-Seq_HEART_Mouse1.17806555
98TBX20_22328084_ChIP-Seq_HEART_Mouse1.17806555
99KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17764140
100* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17615319
101JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17487872
102* SMAD3_21741376_ChIP-Seq_ESCs_Human1.15725178
103TP53_20018659_ChIP-ChIP_R1E_Mouse1.15506070
104ESR1_21235772_ChIP-Seq_MCF-7_Human1.13892077
105MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13310659
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.12662661
107ERG_21242973_ChIP-ChIP_JURKAT_Human1.12551217
108CJUN_26792858_Chip-Seq_BT549_Human1.12414695
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.12410580
110HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12019340
111KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11703593
112TP53_22127205_ChIP-Seq_IMR90_Human1.11313229
113PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10998496
114KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10168510
115KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10168510
116KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10168510
117E2F4_17652178_ChIP-ChIP_JURKAT_Human1.10078506
118CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10068798
119KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09923228
120SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09915558
121P300_19829295_ChIP-Seq_ESCs_Human1.09904356
122CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07408055
123RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06960538
124OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06090424
125RING1B_27294783_Chip-Seq_ESCs_Mouse1.05205459
126* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04976573
127* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.04654173
128CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03563396
129* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02978180
130SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02831214
131* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02711638
132PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02035184
133TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01735567
134GATA2_21666600_ChIP-Seq_HMVEC_Human1.01397351
135CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01368872
136EZH2_27294783_Chip-Seq_ESCs_Mouse1.00798270
137HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99843540
138CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99470028
139SMAD3_21741376_ChIP-Seq_EPCs_Human0.99154056
140SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.98796880
141LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98674223
142ZNF274_21170338_ChIP-Seq_K562_Hela0.98129618
143* AR_19668381_ChIP-Seq_PC3_Human0.98012777
144SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97912175
145SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95823688

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.33353540
2MP0005623_abnormal_meninges_morphology3.16526525
3MP0004272_abnormal_basement_membrane3.04498095
4MP0008438_abnormal_cutaneous_collagen2.94785944
5MP0003705_abnormal_hypodermis_morpholog2.92369038
6MP0006292_abnormal_olfactory_placode2.80431722
7MP0003136_yellow_coat_color2.57390742
8MP0000566_synostosis2.19734815
9MP0004858_abnormal_nervous_system2.16402490
10MP0005257_abnormal_intraocular_pressure2.10180418
11MP0000733_abnormal_muscle_development2.04603580
12MP0003890_abnormal_embryonic-extraembry1.98399458
13MP0005076_abnormal_cell_differentiation1.96126782
14MP0001958_emphysema1.94612942
15MP0003279_aneurysm1.91276092
16MP0002254_reproductive_system_inflammat1.87823543
17MP0003091_abnormal_cell_migration1.75237631
18MP0003938_abnormal_ear_development1.72842486
19MP0010368_abnormal_lymphatic_system1.71398019
20MP0009672_abnormal_birth_weight1.67338338
21MP0000751_myopathy1.65956561
22MP0003941_abnormal_skin_development1.64442908
23MP0003878_abnormal_ear_physiology1.63961983
24MP0005377_hearing/vestibular/ear_phenot1.63961983
25MP0001177_atelectasis1.63438160
26MP0004859_abnormal_synaptic_plasticity1.62940088
27MP0000428_abnormal_craniofacial_morphol1.62761017
28MP0003950_abnormal_plasma_membrane1.61896941
29MP0003385_abnormal_body_wall1.60687749
30MP0001286_abnormal_eye_development1.56724025
31MP0004133_heterotaxia1.54897859
32MP0003566_abnormal_cell_adhesion1.53933529
33MP0003123_paternal_imprinting1.53761150
34MP0005167_abnormal_blood-brain_barrier1.53584094
35MP0004084_abnormal_cardiac_muscle1.53485341
36MP0001879_abnormal_lymphatic_vessel1.51420489
37MP0000778_abnormal_nervous_system1.48438262
38MP0000767_abnormal_smooth_muscle1.47725597
39MP0003115_abnormal_respiratory_system1.46228176
40MP0002938_white_spotting1.44671458
41MP0005670_abnormal_white_adipose1.44400018
42MP0003880_abnormal_central_pattern1.43430492
43MP0001299_abnormal_eye_distance/1.42523932
44MP0000579_abnormal_nail_morphology1.39192034
45MP0000534_abnormal_ureter_morphology1.38920959
46MP0010352_gastrointestinal_tract_polyps1.38459465
47MP0010030_abnormal_orbit_morphology1.36493068
48MP0000955_abnormal_spinal_cord1.36462320
49MP0000537_abnormal_urethra_morphology1.36322613
50MP0003787_abnormal_imprinting1.35221903
51MP0003283_abnormal_digestive_organ1.35159100
52MP0003942_abnormal_urinary_system1.33619138
53MP0003828_pulmonary_edema1.32484104
54MP0003935_abnormal_craniofacial_develop1.29651410
55MP0000750_abnormal_muscle_regeneration1.29066078
56MP0002152_abnormal_brain_morphology1.28389289
57MP0004233_abnormal_muscle_weight1.25810098
58MP0002249_abnormal_larynx_morphology1.25764822
59MP0009250_abnormal_appendicular_skeleto1.25017386
60MP0001486_abnormal_startle_reflex1.22860238
61MP0005171_absent_coat_pigmentation1.21840639
62MP0001915_intracranial_hemorrhage1.21642268
63MP0002925_abnormal_cardiovascular_devel1.21402374
64MP0002111_abnormal_tail_morphology1.20903006
65MP0004197_abnormal_fetal_growth/weight/1.20588289
66MP0005248_abnormal_Harderian_gland1.20554794
67MP0004087_abnormal_muscle_fiber1.19311133
68MP0009703_decreased_birth_body1.17444154
69MP0001849_ear_inflammation1.17259531
70MP0005503_abnormal_tendon_morphology1.16797925
71MP0003937_abnormal_limbs/digits/tail_de1.16554015
72MP0010630_abnormal_cardiac_muscle1.15939343
73MP0003634_abnormal_glial_cell1.15861563
74MP0005423_abnormal_somatic_nervous1.14846796
75MP0006138_congestive_heart_failure1.13954422
76MP0003755_abnormal_palate_morphology1.12624754
77MP0008877_abnormal_DNA_methylation1.10492384
78MP0004130_abnormal_muscle_cell1.08462202
79* MP0002697_abnormal_eye_size1.08311799
80MP0003567_abnormal_fetal_cardiomyocyte1.07313053
81MP0003303_peritoneal_inflammation1.06411391
82* MP0002081_perinatal_lethality1.06398636
83MP0000631_abnormal_neuroendocrine_gland1.05875178
84MP0008932_abnormal_embryonic_tissue1.05523861
85MP0001984_abnormal_olfaction1.05433233
86MP0005508_abnormal_skeleton_morphology1.04621546
87MP0004134_abnormal_chest_morphology1.04592728
88MP0008057_abnormal_DNA_replication1.04284444
89MP0000432_abnormal_head_morphology1.02828668
90MP0009780_abnormal_chondrocyte_physiolo1.02791646
91MP0002736_abnormal_nociception_after1.02036727
92MP0000049_abnormal_middle_ear1.01756377
93MP0003300_gastrointestinal_ulcer1.01540375
94MP0004270_analgesia1.00668249
95MP0003635_abnormal_synaptic_transmissio1.00603952
96MP0010307_abnormal_tumor_latency1.00460097
97MP0005499_abnormal_olfactory_system1.00172295
98MP0005394_taste/olfaction_phenotype1.00172295
99MP0002116_abnormal_craniofacial_bone0.99844133
100MP0001614_abnormal_blood_vessel0.99505999
101MP0004885_abnormal_endolymph0.98409323
102MP0005391_vision/eye_phenotype0.98282875
103MP0004185_abnormal_adipocyte_glucose0.97894485
104MP0002128_abnormal_blood_circulation0.97394382
105MP0002653_abnormal_ependyma_morphology0.97384846
106MP0003111_abnormal_nucleus_morphology0.96930995
107MP0002089_abnormal_postnatal_growth/wei0.95756885
108MP0002084_abnormal_developmental_patter0.95710998
109MP0002734_abnormal_mechanical_nocicepti0.95355751
110MP0003861_abnormal_nervous_system0.95235331
111MP0005666_abnormal_adipose_tissue0.94851667
112* MP0009278_abnormal_bone_marrow0.94376202
113MP0003121_genomic_imprinting0.94306667
114MP0000516_abnormal_urinary_system0.93585423
115MP0005367_renal/urinary_system_phenotyp0.93585423
116MP0002751_abnormal_autonomic_nervous0.92893852
117MP0001485_abnormal_pinna_reflex0.92683121
118MP0002932_abnormal_joint_morphology0.92282983
119MP0002085_abnormal_embryonic_tissue0.92046180
120MP0004145_abnormal_muscle_electrophysio0.91269273
121MP0005197_abnormal_uvea_morphology0.90790726
122MP0008789_abnormal_olfactory_epithelium0.90111630
123MP0002092_abnormal_eye_morphology0.89469030
124MP0000759_abnormal_skeletal_muscle0.89258633
125MP0005375_adipose_tissue_phenotype0.88795141
126MP0009053_abnormal_anal_canal0.88191124
127MP0004957_abnormal_blastocyst_morpholog0.88066730
128MP0003122_maternal_imprinting0.88024497
129MP0000266_abnormal_heart_morphology0.87733905
130MP0002063_abnormal_learning/memory/cond0.87693636
131MP0003984_embryonic_growth_retardation0.86835211
132MP0002088_abnormal_embryonic_growth/wei0.86780934
133MP0002184_abnormal_innervation0.86437006
134MP0002882_abnormal_neuron_morphology0.84818592
135MP0002233_abnormal_nose_morphology0.84504765
136MP0002752_abnormal_somatic_nervous0.84364141
137MP0005409_darkened_coat_color0.84015510
138MP0001672_abnormal_embryogenesis/_devel0.82793487
139MP0005380_embryogenesis_phenotype0.82793487
140MP0003690_abnormal_glial_cell0.81267572
141MP0005385_cardiovascular_system_phenoty0.80521338
142MP0001544_abnormal_cardiovascular_syste0.80521338
143* MP0002108_abnormal_muscle_morphology0.80390159
144MP0003045_fibrosis0.80073897
145MP0003119_abnormal_digestive_system0.79743415
146MP0001293_anophthalmia0.79500090
147MP0005275_abnormal_skin_tensile0.78721361
148* MP0003448_altered_tumor_morphology0.78668799
149MP0000026_abnormal_inner_ear0.78666149
150MP0002114_abnormal_axial_skeleton0.78606050
151MP0003632_abnormal_nervous_system0.78573726
152MP0009379_abnormal_foot_pigmentation0.78233294
153MP0001346_abnormal_lacrimal_gland0.78004420
154MP0001697_abnormal_embryo_size0.77823171

Predicted human phenotypes

RankGene SetZ-score
1Shallow orbits (HP:0000586)3.92667869
2Cerebral aneurysm (HP:0004944)3.44242830
3Short 4th metacarpal (HP:0010044)3.42203013
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.42203013
5Septo-optic dysplasia (HP:0100842)3.32494436
6Abnormality of the 4th metacarpal (HP:0010012)2.99671424
7Hepatoblastoma (HP:0002884)2.94178212
8Premature rupture of membranes (HP:0001788)2.84102602
9Broad metatarsal (HP:0001783)2.82532497
10Vitreoretinal degeneration (HP:0000655)2.75806429
11Choanal stenosis (HP:0000452)2.67938012
12Colon cancer (HP:0003003)2.61183067
13Cutaneous finger syndactyly (HP:0010554)2.58312914
14Hyperacusis (HP:0010780)2.55039492
15High anterior hairline (HP:0009890)2.54359941
16Cutaneous syndactyly (HP:0012725)2.53303923
17Aplasia/Hypoplasia of the sternum (HP:0006714)2.51342300
18Bladder diverticulum (HP:0000015)2.49819768
19Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.49261607
20Anophthalmia (HP:0000528)2.48435477
21Ankle contracture (HP:0006466)2.48379810
22Partial duplication of thumb phalanx (HP:0009944)2.45704373
23Renal duplication (HP:0000075)2.43320407
24Bilateral microphthalmos (HP:0007633)2.41586551
25Abnormal number of incisors (HP:0011064)2.33150061
26Adactyly (HP:0009776)2.31785424
27Protrusio acetabuli (HP:0003179)2.31109306
28Abnormality of the labia minora (HP:0012880)2.30180567
29Difficulty running (HP:0009046)2.26517656
30Skull defect (HP:0001362)2.25022681
31Elfin facies (HP:0004428)2.21543573
32Preaxial foot polydactyly (HP:0001841)2.20766817
33Partial duplication of the phalanx of hand (HP:0009999)2.20027005
34Spastic diplegia (HP:0001264)2.19176817
35Scapular winging (HP:0003691)2.14969031
36Abnormality of the septum pellucidum (HP:0007375)2.14381040
37Flat cornea (HP:0007720)2.11686682
38Aortic aneurysm (HP:0004942)2.09580906
39Genu recurvatum (HP:0002816)2.09477791
40Absent septum pellucidum (HP:0001331)2.09384870
41Wrist flexion contracture (HP:0001239)2.09356788
42Rib fusion (HP:0000902)2.08412335
43Trigonocephaly (HP:0000243)2.08400751
44Bowel diverticulosis (HP:0005222)2.07470876
45Renal hypoplasia (HP:0000089)2.07443342
46Hematochezia (HP:0002573)2.07032019
47Bronchomalacia (HP:0002780)2.06117958
48Overriding aorta (HP:0002623)2.03420293
49Hypoplastic ischia (HP:0003175)2.01256275
50Enlarged penis (HP:0000040)2.00169880
51Ectopic kidney (HP:0000086)1.99850685
52Asymmetry of the thorax (HP:0001555)1.99377498
53Obsessive-compulsive behavior (HP:0000722)1.97435230
54Lymphangioma (HP:0100764)1.97395022
55Cortical dysplasia (HP:0002539)1.97109019
56Difficulty climbing stairs (HP:0003551)1.94157400
57Esophageal atresia (HP:0002032)1.93717805
58Aortic dissection (HP:0002647)1.93577242
59Increased connective tissue (HP:0009025)1.93534232
60Duplication of thumb phalanx (HP:0009942)1.92492551
61Renovascular hypertension (HP:0100817)1.91233756
62Split foot (HP:0001839)1.90413002
63Buphthalmos (HP:0000557)1.88462652
64Bifid tongue (HP:0010297)1.88103082
65Vertebral clefting (HP:0008428)1.87434100
66Coronal craniosynostosis (HP:0004440)1.86191912
67Intestinal atresia (HP:0011100)1.85607262
68Spinal rigidity (HP:0003306)1.84969755
69Omphalocele (HP:0001539)1.84727864
70Lower limb amyotrophy (HP:0007210)1.84164134
71Abnormality of the diencephalon (HP:0010662)1.83912695
72Broad thumb (HP:0011304)1.83309162
73Hemivertebrae (HP:0002937)1.81763096
74Megalocornea (HP:0000485)1.81424723
75Muscle fiber splitting (HP:0003555)1.81204520
76Partial agenesis of the corpus callosum (HP:0001338)1.81087166
77Dilatation of the ascending aorta (HP:0005111)1.80679918
78Aplasia/Hypoplasia of the breasts (HP:0010311)1.79865076
79Megalencephaly (HP:0001355)1.79835404
80Pointed chin (HP:0000307)1.79139035
81Mitral valve prolapse (HP:0001634)1.78948283
82Broad ribs (HP:0000885)1.78490929
83Deviation of the hallux (HP:0010051)1.77929818
84Metaphyseal cupping (HP:0003021)1.77706196
85Breast aplasia (HP:0100783)1.77496267
86Abnormality of the astrocytes (HP:0100707)1.77387426
87Astrocytoma (HP:0009592)1.77387426
88Morphological abnormality of the inner ear (HP:0011390)1.77219415
89Subacute progressive viral hepatitis (HP:0006572)1.77078069
90Optic nerve hypoplasia (HP:0000609)1.76768541
91Aqueductal stenosis (HP:0002410)1.76503103
92Myelomeningocele (HP:0002475)1.76316240
93Oligodactyly (HP:0012165)1.75403791
94Abnormality of the antihelix (HP:0009738)1.75181345
95Ependymoma (HP:0002888)1.74004710
96Oligodactyly (hands) (HP:0001180)1.73842481
97Increased nuchal translucency (HP:0010880)1.73832009
98Upper limb amyotrophy (HP:0009129)1.72523008
99Distal upper limb amyotrophy (HP:0007149)1.72523008
100Abnormality of cochlea (HP:0000375)1.71995547
101Arnold-Chiari malformation (HP:0002308)1.71719227
102Maternal diabetes (HP:0009800)1.70833319
103Aneurysm (HP:0002617)1.70312798
104Arterial tortuosity (HP:0005116)1.69965662
105Abnormality of the aortic arch (HP:0012303)1.69941765
106Vascular tortuosity (HP:0004948)1.68928039
107Macroorchidism (HP:0000053)1.68893169
108Selective tooth agenesis (HP:0001592)1.68246508
109Abnormality of the ischium (HP:0003174)1.67760157
110Leiomyosarcoma (HP:0100243)1.66688402
111Uterine leiomyosarcoma (HP:0002891)1.66688402
112Distal lower limb amyotrophy (HP:0008944)1.66623241
113Turricephaly (HP:0000262)1.66500431
114Supernumerary ribs (HP:0005815)1.66444755
115Thin ribs (HP:0000883)1.66142584
116Midline defect of the nose (HP:0004122)1.65454097
117Obstructive sleep apnea (HP:0002870)1.65224952
118Increased density of long bones (HP:0006392)1.64100008
119Gastrointestinal atresia (HP:0002589)1.64099519
120Narrow palate (HP:0000189)1.64083229
121Hallux valgus (HP:0001822)1.63626031
122Broad phalanges of the hand (HP:0009768)1.63272123
123Nephroblastoma (Wilms tumor) (HP:0002667)1.62976186
124Glioma (HP:0009733)1.61939523
125Exostoses (HP:0100777)1.61686599
126Vertebral arch anomaly (HP:0008438)1.61604401
127Hyporeflexia of lower limbs (HP:0002600)1.61006576
128Hip contracture (HP:0003273)1.59862233
129Abnormality of the parietal bone (HP:0002696)1.59704289
130Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.59408765
131Wide anterior fontanel (HP:0000260)1.59077581
132Aplasia involving bones of the upper limbs (HP:0009823)1.58588667
133Aplasia of the phalanges of the hand (HP:0009802)1.58588667
134Aplasia involving bones of the extremities (HP:0009825)1.58588667
135Broad finger (HP:0001500)1.58392176
136Overgrowth (HP:0001548)1.58318210
137Pseudobulbar signs (HP:0002200)1.58203041
138Abnormality of the distal phalanx of the thumb (HP:0009617)1.58060478
139Relative macrocephaly (HP:0004482)1.58051375
140Abnormality of the carotid arteries (HP:0005344)1.57282331
141Abnormality of the incisor (HP:0000676)1.57109466
142Pulmonary artery stenosis (HP:0004415)1.55539522
143Increased variability in muscle fiber diameter (HP:0003557)1.55345754
144Type 1 muscle fiber predominance (HP:0003803)1.55080960
145Supernumerary bones of the axial skeleton (HP:0009144)1.54858226
146Absent frontal sinuses (HP:0002688)1.54551725
147Cupped ear (HP:0000378)1.54439068
148Disproportionate tall stature (HP:0001519)1.54398389
149Broad long bones (HP:0005622)1.53928011
150Patellar dislocation (HP:0002999)1.53879452
151Bicuspid aortic valve (HP:0001647)1.53292123
152Aplasia/Hypoplasia of the clavicles (HP:0006710)1.52993955
153Broad phalanx (HP:0006009)1.52761025
154Insomnia (HP:0100785)1.52519450
155Limb-girdle muscle weakness (HP:0003325)1.52247416
156Joint laxity (HP:0001388)1.49693464
157Disinhibition (HP:0000734)1.49527799
158Absent toe (HP:0010760)1.49480037
159Abnormality of the pubic bones (HP:0003172)1.48729841
160Abnormality of the shoulder girdle musculature (HP:0001435)1.47136445
161Transitional cell carcinoma of the bladder (HP:0006740)1.46846429
162Hypoplasia of the iris (HP:0007676)1.46242299
163Fibroma (HP:0010614)1.45942649
164Spinal muscular atrophy (HP:0007269)1.45633818

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.51399190
2TNIK3.27226943
3TTN3.20162614
4CASK2.85134551
5RIPK12.77023071
6CAMK1G2.68138101
7PDGFRA2.64126505
8CAMK1D2.63130232
9DDR22.25105143
10TAF12.13947621
11DYRK22.04355432
12CDK122.01812737
13PAK62.00392643
14EPHB21.99963841
15WNK31.97997046
16TIE11.95778695
17DMPK1.94352940
18PRKD31.93762188
19MAP3K101.92356748
20LATS11.87825634
21LATS21.83858193
22MARK11.81840818
23TYRO31.76781734
24PKN21.75764255
25TTK1.74884321
26PTK61.69999167
27STK38L1.67456900
28ICK1.64963020
29BMX1.56891859
30PDGFRB1.47010118
31SIK11.41333889
32MTOR1.41311521
33PAK21.40375298
34NTRK31.38070017
35SCYL21.31972946
36CDK61.31320550
37SMG11.28842634
38PLK31.24818180
39PAK41.22721926
40PHKG21.22717811
41PHKG11.22717811
42YES11.18986656
43EPHB11.17830910
44NTRK11.17773258
45EPHA41.15374120
46ALK1.12218048
47TSSK61.11054103
48SIK21.07978000
49NTRK21.05868823
50FER1.04692837
51LIMK11.03031909
52KSR10.99632215
53ILK0.99349790
54FGFR20.98095368
55PTK20.98003406
56DYRK1B0.95757402
57ERBB20.94835581
58PRKCH0.94546721
59NEK20.93895348
60SRPK10.92600391
61FGR0.91377059
62PTK2B0.90822110
63SGK2230.90311381
64SGK4940.90311381
65DYRK1A0.88407252
66UHMK10.87156785
67SGK20.86930685
68FGFR10.86836888
69TGFBR20.86750416
70ROCK10.86225394
71MARK20.86221904
72DYRK30.85616210
73KDR0.83992914
74STK30.81550144
75EEF2K0.81313637
76ERBB40.80897285
77PLK40.80296340
78BRD40.77971574
79CDK190.76491139
80WEE10.73136094
81MET0.72865397
82CSNK1A1L0.72531430
83LMTK20.71692818
84CHEK20.71320504
85FGFR30.70469965
86STK110.68504263
87PNCK0.68178745
88PAK30.66637765
89MAP3K90.66144134
90OXSR10.66088378
91DAPK20.65288735
92GSK3A0.64701618
93PRKDC0.64606074
94NEK10.64540688
95RET0.64426849
96EPHA30.63760668
97CDK140.62677143
98CAMKK10.62440453
99PLK20.62427354
100CDK150.61666985
101CDC42BPA0.61606901
102CDK10.60849707
103ROCK20.60826690
104PRKD10.60657640
105NUAK10.60205097
106SRC0.59100041
107ATR0.58063192
108PKN10.57848151
109FGFR40.57432797
110MKNK10.56943830
111CDK180.56727831
112ERBB30.56019718
113NEK90.55599465
114ATM0.54106388
115PRKCZ0.53962361
116CHEK10.52164597
117CSNK1E0.51977420
118CDK11A0.51952487
119KSR20.51629094
120TESK10.50816759
121CSNK1G10.50377595
122CDK20.50022001
123CSNK1G20.49437910
124EGFR0.49367687
125VRK20.47295039
126GSK3B0.46658460
127PLK10.46585865
128PDK20.46257023
129TGFBR10.45963696
130FLT30.45402540
131MINK10.45011340
132NLK0.44462071
133IGF1R0.43876859
134RPS6KA20.43769285
135AKT10.43420515
136STK380.43125604
137MKNK20.42532872
138CDK50.41826855
139CDK70.41039566
140MAPK80.40939453
141MOS0.40937327
142AKT20.40734448
143CSNK1D0.40303721
144MAPK100.40271021
145INSR0.40188125
146CDK30.39238058
147CDC70.36012279
148MAPK90.35997615
149WNK10.35121230
150SGK30.34890367

Predicted pathways (KEGG)

RankGene SetZ-score
1Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.99594511
2Focal adhesion_Homo sapiens_hsa045101.96797528
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.92844181
4Adherens junction_Homo sapiens_hsa045201.91658409
5Viral myocarditis_Homo sapiens_hsa054161.91156032
6ECM-receptor interaction_Homo sapiens_hsa045121.84252819
7Dilated cardiomyopathy_Homo sapiens_hsa054141.79285537
8Non-homologous end-joining_Homo sapiens_hsa034501.72930641
9Basal cell carcinoma_Homo sapiens_hsa052171.72178891
10Hippo signaling pathway_Homo sapiens_hsa043901.66674828
11Proteoglycans in cancer_Homo sapiens_hsa052051.66643689
12Axon guidance_Homo sapiens_hsa043601.63007416
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.61783094
14MicroRNAs in cancer_Homo sapiens_hsa052061.60856410
15Chronic myeloid leukemia_Homo sapiens_hsa052201.58463960
16Mismatch repair_Homo sapiens_hsa034301.57507154
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.56269097
18Dorso-ventral axis formation_Homo sapiens_hsa043201.56030619
19Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.53583223
20Notch signaling pathway_Homo sapiens_hsa043301.52837761
21Glioma_Homo sapiens_hsa052141.52528030
22DNA replication_Homo sapiens_hsa030301.44735635
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.43120139
24Small cell lung cancer_Homo sapiens_hsa052221.43008244
25Nicotine addiction_Homo sapiens_hsa050331.41961984
26Colorectal cancer_Homo sapiens_hsa052101.37806502
27Endometrial cancer_Homo sapiens_hsa052131.36530512
28Regulation of actin cytoskeleton_Homo sapiens_hsa048101.35933973
29Hedgehog signaling pathway_Homo sapiens_hsa043401.35633236
30Thyroid cancer_Homo sapiens_hsa052161.32559674
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.31826517
32Renal cell carcinoma_Homo sapiens_hsa052111.31176239
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.30439152
34Glutamatergic synapse_Homo sapiens_hsa047241.29942625
35Tight junction_Homo sapiens_hsa045301.27556225
36Thyroid hormone signaling pathway_Homo sapiens_hsa049191.24752599
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22971819
38mRNA surveillance pathway_Homo sapiens_hsa030151.20189429
39Pancreatic cancer_Homo sapiens_hsa052121.19721550
40Melanoma_Homo sapiens_hsa052181.19705385
41Rap1 signaling pathway_Homo sapiens_hsa040151.17556367
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.16300866
43Amoebiasis_Homo sapiens_hsa051461.09485936
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08714084
45Morphine addiction_Homo sapiens_hsa050321.07542289
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.06875090
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06337954
48Spliceosome_Homo sapiens_hsa030401.06327447
49Melanogenesis_Homo sapiens_hsa049161.06261117
50Pathways in cancer_Homo sapiens_hsa052001.04059867
51Gap junction_Homo sapiens_hsa045401.04015461
52Wnt signaling pathway_Homo sapiens_hsa043101.03106852
53Phospholipase D signaling pathway_Homo sapiens_hsa040721.02932644
54TGF-beta signaling pathway_Homo sapiens_hsa043501.02816860
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02073859
56mTOR signaling pathway_Homo sapiens_hsa041501.01966755
57Estrogen signaling pathway_Homo sapiens_hsa049151.01653178
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00869554
59Bladder cancer_Homo sapiens_hsa052190.99899139
60Prostate cancer_Homo sapiens_hsa052150.98826504
61Endocytosis_Homo sapiens_hsa041440.96536155
62ErbB signaling pathway_Homo sapiens_hsa040120.95820524
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95146510
64GABAergic synapse_Homo sapiens_hsa047270.92577608
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92504104
66Selenocompound metabolism_Homo sapiens_hsa004500.92063819
67Fanconi anemia pathway_Homo sapiens_hsa034600.91816021
68RNA transport_Homo sapiens_hsa030130.91697244
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90027129
70Non-small cell lung cancer_Homo sapiens_hsa052230.89372702
71PI3K-Akt signaling pathway_Homo sapiens_hsa041510.89293749
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87858851
73HTLV-I infection_Homo sapiens_hsa051660.85689480
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85194831
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.84568737
76Oxytocin signaling pathway_Homo sapiens_hsa049210.84330715
77VEGF signaling pathway_Homo sapiens_hsa043700.83859868
78Platelet activation_Homo sapiens_hsa046110.83498683
79Thyroid hormone synthesis_Homo sapiens_hsa049180.83140133
80Lysine degradation_Homo sapiens_hsa003100.81541903
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80597673
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80284590
83Insulin signaling pathway_Homo sapiens_hsa049100.78940413
84AMPK signaling pathway_Homo sapiens_hsa041520.78551704
85Cocaine addiction_Homo sapiens_hsa050300.77565886
86Homologous recombination_Homo sapiens_hsa034400.77471950
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.77198899
88Lysosome_Homo sapiens_hsa041420.77011125
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76860758
90Type II diabetes mellitus_Homo sapiens_hsa049300.75701591
91Toxoplasmosis_Homo sapiens_hsa051450.75595991
92Basal transcription factors_Homo sapiens_hsa030220.75365596
93Renin secretion_Homo sapiens_hsa049240.74916442
94Oocyte meiosis_Homo sapiens_hsa041140.74282204
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.73429033
96MAPK signaling pathway_Homo sapiens_hsa040100.73144818
97Dopaminergic synapse_Homo sapiens_hsa047280.71912398
98Ras signaling pathway_Homo sapiens_hsa040140.71442529
99HIF-1 signaling pathway_Homo sapiens_hsa040660.70905887
100GnRH signaling pathway_Homo sapiens_hsa049120.70246128
101Taste transduction_Homo sapiens_hsa047420.69309242
102Salmonella infection_Homo sapiens_hsa051320.69000327
103FoxO signaling pathway_Homo sapiens_hsa040680.67225101
104Shigellosis_Homo sapiens_hsa051310.66823954
105Cholinergic synapse_Homo sapiens_hsa047250.65472341
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65301555
107cAMP signaling pathway_Homo sapiens_hsa040240.63940696
108Insulin resistance_Homo sapiens_hsa049310.63096898
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62932232
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62758683
111Chemokine signaling pathway_Homo sapiens_hsa040620.62057025
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62025180
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60689630
114Gastric acid secretion_Homo sapiens_hsa049710.60374420
115Long-term depression_Homo sapiens_hsa047300.60325607
116Osteoclast differentiation_Homo sapiens_hsa043800.60237352
117Cell cycle_Homo sapiens_hsa041100.60065080
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59268148
119Serotonergic synapse_Homo sapiens_hsa047260.59030521
120Circadian entrainment_Homo sapiens_hsa047130.58253543
121Choline metabolism in cancer_Homo sapiens_hsa052310.57278986
122Fatty acid biosynthesis_Homo sapiens_hsa000610.57214277
123Prion diseases_Homo sapiens_hsa050200.57123631
124Base excision repair_Homo sapiens_hsa034100.56913059
125Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55610671
126Malaria_Homo sapiens_hsa051440.55027101
127Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53326423
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.51990941
129Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51794684
130Steroid biosynthesis_Homo sapiens_hsa001000.48442978
131Protein digestion and absorption_Homo sapiens_hsa049740.48218539
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47793802
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47782975

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