HIP1R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)4.60453191
2glutamate secretion (GO:0014047)4.29458232
3locomotory exploration behavior (GO:0035641)4.04785080
4synaptic vesicle exocytosis (GO:0016079)3.97743836
5positive regulation of Rap GTPase activity (GO:0032854)3.89049681
6L-amino acid import (GO:0043092)3.84582989
7amino acid import (GO:0043090)3.77568598
8positive regulation of synapse maturation (GO:0090129)3.73182993
9regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.56745386
10cellular potassium ion homeostasis (GO:0030007)3.51914911
11cell migration in hindbrain (GO:0021535)3.47733061
12regulation of Rap GTPase activity (GO:0032317)3.45266960
13cerebellar granule cell differentiation (GO:0021707)3.38252288
14cytoskeletal anchoring at plasma membrane (GO:0007016)3.38200352
15regulation of ARF protein signal transduction (GO:0032012)3.29798065
16antigen processing and presentation of endogenous antigen (GO:0019883)3.27904762
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.22922591
18neurotransmitter secretion (GO:0007269)3.22848161
19postsynaptic membrane organization (GO:0001941)3.22134575
20protein localization to endosome (GO:0036010)3.21733536
21positive regulation of histone deacetylation (GO:0031065)3.18312993
22semaphorin-plexin signaling pathway (GO:0071526)3.13232087
23regulation of ARF GTPase activity (GO:0032312)3.07633283
24regulation of synapse maturation (GO:0090128)3.04902429
25axon ensheathment in central nervous system (GO:0032291)3.04829421
26central nervous system myelination (GO:0022010)3.04829421
27vocalization behavior (GO:0071625)3.01698733
28B cell receptor signaling pathway (GO:0050853)3.00203839
29myelin maintenance (GO:0043217)2.99113546
30dopamine receptor signaling pathway (GO:0007212)2.97219400
31peptidyl-tyrosine autophosphorylation (GO:0038083)2.96993168
32synaptic vesicle maturation (GO:0016188)2.95885717
33regulation of neuronal synaptic plasticity (GO:0048168)2.95633872
34regulation of synapse structural plasticity (GO:0051823)2.94729692
35nerve growth factor signaling pathway (GO:0038180)2.94106799
36establishment of mitochondrion localization (GO:0051654)2.93070098
37ionotropic glutamate receptor signaling pathway (GO:0035235)2.92230097
38protein targeting to Golgi (GO:0000042)2.89353956
39positive thymic T cell selection (GO:0045059)2.86786606
40cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.85586435
41cell-cell junction maintenance (GO:0045217)2.83751220
42establishment of protein localization to Golgi (GO:0072600)2.82745533
43negative regulation of GTP catabolic process (GO:0033125)2.82572110
44negative regulation of GTPase activity (GO:0034260)2.82572110
45antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.81192204
46antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.81192204
47dendritic spine organization (GO:0097061)2.77473976
48Golgi transport vesicle coating (GO:0048200)2.71955091
49COPI coating of Golgi vesicle (GO:0048205)2.71955091
50positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.69995268
51mannose metabolic process (GO:0006013)2.68460395
52establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.68435178
53mitochondrion transport along microtubule (GO:0047497)2.68435178
54endocrine pancreas development (GO:0031018)2.67163775
55regulation of glutamate receptor signaling pathway (GO:1900449)2.66254300
56regulation of synaptic plasticity (GO:0048167)2.64650287
57positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.64486330
58cerebellar Purkinje cell differentiation (GO:0021702)2.64134209
59negative regulation of inclusion body assembly (GO:0090084)2.63934031
60adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.63426762
61retrograde transport, vesicle recycling within Golgi (GO:0000301)2.62436784
62regulation of synaptic vesicle exocytosis (GO:2000300)2.60481737
63positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.58848835
64negative regulation of glycoprotein biosynthetic process (GO:0010561)2.57162446
65neuromuscular process controlling balance (GO:0050885)2.56656569
66negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.54351767
67cell communication by electrical coupling (GO:0010644)2.53329150
68synaptic vesicle endocytosis (GO:0048488)2.53255958
69potassium ion import (GO:0010107)2.52390561
70signal complex assembly (GO:0007172)2.51880932
71L-serine transport (GO:0015825)2.51613522
72desmosome organization (GO:0002934)2.49033280
73thymic T cell selection (GO:0045061)2.47969446
74vesicle targeting (GO:0006903)2.46486494
75negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.46295217
76regulation of long-term neuronal synaptic plasticity (GO:0048169)2.45887219
77neurotransmitter transport (GO:0006836)2.45527369
78dendritic spine morphogenesis (GO:0060997)2.43240368
79regulation of short-term neuronal synaptic plasticity (GO:0048172)2.42319472
80activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.42273893
81regulation of cholesterol biosynthetic process (GO:0045540)2.40741214
82receptor recycling (GO:0001881)2.40371206
83cell junction maintenance (GO:0034331)2.40296348
84lipid translocation (GO:0034204)2.39981459
85phospholipid translocation (GO:0045332)2.39981459
86negative regulation of erythrocyte differentiation (GO:0045647)2.39262062
87long-term synaptic potentiation (GO:0060291)2.38291378
88activation of Rac GTPase activity (GO:0032863)2.37896583
89regulation of gamma-delta T cell differentiation (GO:0045586)2.37528462
90cellular sodium ion homeostasis (GO:0006883)2.37328631
91serine transport (GO:0032329)2.36657967
92regulation of Golgi to plasma membrane protein transport (GO:0042996)2.36610538
93oligodendrocyte differentiation (GO:0048709)2.36054313
94cellular response to catecholamine stimulus (GO:0071870)2.35815293
95cellular response to monoamine stimulus (GO:0071868)2.35815293
96multicellular organismal water homeostasis (GO:0050891)2.33988182
97axon ensheathment (GO:0008366)2.33611130
98ensheathment of neurons (GO:0007272)2.33611130
99glycine transport (GO:0015816)2.33295398
100establishment of skin barrier (GO:0061436)2.32754086
101sodium ion export (GO:0071436)2.32733743
102membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.31354534
103auditory behavior (GO:0031223)2.31056899
104negative regulation of nucleotide catabolic process (GO:0030812)2.30887135
105hemidesmosome assembly (GO:0031581)2.30450946
106layer formation in cerebral cortex (GO:0021819)2.30283693
107neurotransmitter-gated ion channel clustering (GO:0072578)2.30060856
108positive regulation of insulin secretion (GO:0032024)2.30000756
109presynaptic membrane organization (GO:0097090)2.29849089
110Golgi to endosome transport (GO:0006895)2.29815653
111regulation of neurotransmitter levels (GO:0001505)2.29718044
112filopodium assembly (GO:0046847)2.29701455
113positive regulation of membrane potential (GO:0045838)2.29379261
114regulation of extracellular matrix disassembly (GO:0010715)2.28904500
115myelination (GO:0042552)2.28751145
116negative regulation of axonogenesis (GO:0050771)2.28560304
117regulation of cholesterol metabolic process (GO:0090181)2.28494514
118cell volume homeostasis (GO:0006884)2.27757770
119cytoplasmic mRNA processing body assembly (GO:0033962)2.27176695
120long-term memory (GO:0007616)2.26137336
121retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.25902186
122regulation of cholesterol homeostasis (GO:2000188)2.25404542
123negative regulation of synaptic transmission, GABAergic (GO:0032229)2.24593573
124regulation of clathrin-mediated endocytosis (GO:2000369)2.24496240
125cell communication involved in cardiac conduction (GO:0086065)2.24487245
126positive regulation of nuclease activity (GO:0032075)2.24146083
127exploration behavior (GO:0035640)2.23542562
128negative regulation of bone resorption (GO:0045779)2.22212861
129neuron cell-cell adhesion (GO:0007158)2.22081545
130positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.21603397
131eye photoreceptor cell differentiation (GO:0001754)2.21156112
132photoreceptor cell differentiation (GO:0046530)2.21156112
133intestinal cholesterol absorption (GO:0030299)2.19700183
134chemosensory behavior (GO:0007635)2.19557419
135negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.19372614
136regulation of axonogenesis (GO:0050770)2.19010508
137adaptation of signaling pathway (GO:0023058)2.17835001
138regulation of beta-amyloid formation (GO:1902003)2.17677955
139maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.17212195
140positive T cell selection (GO:0043368)2.17117059
141cell differentiation in hindbrain (GO:0021533)2.16726001
142positive regulation of gamma-delta T cell activation (GO:0046645)2.16136067
143response to interleukin-15 (GO:0070672)2.16088659
144protein targeting to plasma membrane (GO:0072661)2.15269184
145negative regulation of purine nucleotide catabolic process (GO:0033122)2.15039491
146peptide hormone processing (GO:0016486)2.14086408
147positive regulation of protein deacetylation (GO:0090312)2.13904265
148transmission of nerve impulse (GO:0019226)2.12352402
149creatine metabolic process (GO:0006600)2.12279087
150protein palmitoylation (GO:0018345)2.09884410
151T cell selection (GO:0045058)2.09263005
152positive regulation of growth hormone secretion (GO:0060124)2.09136050
153activation of JUN kinase activity (GO:0007257)2.08795652
154G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.07446300
155activation of protein kinase A activity (GO:0034199)2.06938752
156adenosine receptor signaling pathway (GO:0001973)2.04900492
157regulation of growth hormone secretion (GO:0060123)2.04253132
158regulation of synaptic vesicle transport (GO:1902803)2.03509952
159regulation of water loss via skin (GO:0033561)2.03246864
160neuronal ion channel clustering (GO:0045161)2.03106455
161regulation of nuclease activity (GO:0032069)2.01385534
162asymmetric protein localization (GO:0008105)2.01308056
163positive regulation of CREB transcription factor activity (GO:0032793)2.01155989
164negative regulation of neurotransmitter secretion (GO:0046929)2.00991980
165virion attachment to host cell (GO:0019062)2.00861546
166adhesion of symbiont to host cell (GO:0044650)2.00861546
167protein retention in ER lumen (GO:0006621)2.00149615
168regulation of autophagic vacuole assembly (GO:2000785)2.00073935
169potassium ion homeostasis (GO:0055075)1.99343603

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.64616796
2STAT6_21828071_ChIP-Seq_BEAS2B_Human2.40157734
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.20517413
4DROSHA_22980978_ChIP-Seq_HELA_Human2.14612289
5VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.14284200
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13902425
7* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.04158863
8TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.03196818
9TP63_17297297_ChIP-ChIP_HaCaT_Human1.90278373
10* KDM2B_26808549_Chip-Seq_DND41_Human1.88557193
11ESR2_21235772_ChIP-Seq_MCF-7_Human1.83830855
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82519615
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.81922827
14SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81844495
15RARB_27405468_Chip-Seq_BRAIN_Mouse1.81230441
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.79202559
17* KDM2B_26808549_Chip-Seq_K562_Human1.74505803
18LXR_22292898_ChIP-Seq_THP-1_Human1.71498531
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70943815
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69434915
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69311940
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68227214
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.67086947
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62793117
25* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62489081
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61901354
27RUNX_20019798_ChIP-Seq_JUKART_Human1.58383527
28MYC_22102868_ChIP-Seq_BL_Human1.56442942
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56275951
30DNAJC2_21179169_ChIP-ChIP_NT2_Human1.54868812
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54768940
32SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.53400456
33TCF7_22412390_ChIP-Seq_EML_Mouse1.51020307
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48810617
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47480886
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46387977
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.43464784
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43026805
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42827326
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42009120
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42009120
42* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41155142
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40909476
44SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39485161
45* TET1_21451524_ChIP-Seq_MESCs_Mouse1.39320256
46* KDM2B_26808549_Chip-Seq_JURKAT_Human1.39199116
47GATA1_19941826_ChIP-Seq_K562_Human1.36615600
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.34462250
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34247634
50* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.33592340
51TET1_21490601_ChIP-Seq_MESCs_Mouse1.32155496
52GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31978249
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31170507
54VDR_21846776_ChIP-Seq_THP-1_Human1.28480460
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.26883908
56RUNX1_27514584_Chip-Seq_MCF-7_Human1.26736335
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25671977
58* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25105693
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23734502
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.23048764
61RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22588458
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22512216
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21225884
64REST_21632747_ChIP-Seq_MESCs_Mouse1.19846597
65AR_21572438_ChIP-Seq_LNCaP_Human1.19093751
66CDX2_20551321_ChIP-Seq_CACO-2_Human1.18352384
67RACK7_27058665_Chip-Seq_MCF-7_Human1.17474345
68AHR_22903824_ChIP-Seq_MCF-7_Human1.17220066
69FOXA2_19822575_ChIP-Seq_HepG2_Human1.16546476
70OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16074174
71OCT4_19829295_ChIP-Seq_ESCs_Human1.15995904
72CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14455787
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14358782
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12177541
75EZH2_27304074_Chip-Seq_ESCs_Mouse1.11969909
76ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11430714
77MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10666614
78* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10198748
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09673893
80CTCF_27219007_Chip-Seq_Bcells_Human1.09555115
81CREB1_26743006_Chip-Seq_LNCaP_Human1.08953870
82CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07493937
83SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06865316
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05487958
85FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05442237
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05132619
87REST_18959480_ChIP-ChIP_MESCs_Mouse1.03558323
88JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.03318391
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.03103734
90SMC4_20622854_ChIP-Seq_HELA_Human1.01856963
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01219016
92* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98915052
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98739288
94* TP63_22573176_ChIP-Seq_HFKS_Human0.98709627
95FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98197028
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98192858
97VDR_24763502_ChIP-Seq_THP-1_Human0.98031105
98SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97691173
99UTX_26944678_Chip-Seq_JUKART_Human0.96803774
100ELK3_25401928_ChIP-Seq_HUVEC_Human0.96505910
101NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95985737
102ARNT_22903824_ChIP-Seq_MCF-7_Human0.95254579
103PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95192918
104NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95153590
105DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94886915
106THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94752501
107RING1B_27294783_Chip-Seq_ESCs_Mouse0.94627527
108MAF_26560356_Chip-Seq_TH1_Human0.94078141
109ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93451322
110SA1_27219007_Chip-Seq_Bcells_Human0.93434067
111ESR1_21235772_ChIP-Seq_MCF-7_Human0.93397322
112TP53_23651856_ChIP-Seq_MEFs_Mouse0.92857063
113* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92560701
114TRIM28_21343339_ChIP-Seq_HEK293_Human0.91937749
115GATA1_22025678_ChIP-Seq_K562_Human0.91908540
116GATA2_19941826_ChIP-Seq_K562_Human0.91663211
117P68_20966046_ChIP-Seq_HELA_Human0.90879939
118SPI1_23127762_ChIP-Seq_K562_Human0.89709051
119EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88728427
120P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87972901
121* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86011334
122GATA1_19941827_ChIP-Seq_MEL_Mouse0.85810793
123BCOR_27268052_Chip-Seq_Bcells_Human0.85509511
124P63_26484246_Chip-Seq_KERATINOCYTES_Human0.85278545
125ERG_21242973_ChIP-ChIP_JURKAT_Human0.85119422
126NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85058891
127ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84874824
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84818981
129SA1_27219007_Chip-Seq_ERYTHROID_Human0.84799903
130TBX20_22328084_ChIP-Seq_HEART_Mouse0.84146848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.88738316
2MP0002909_abnormal_adrenal_gland3.48287431
3MP0005409_darkened_coat_color3.30823837
4MP0003300_gastrointestinal_ulcer2.85073398
5MP0008961_abnormal_basal_metabolism2.69828588
6MP0004859_abnormal_synaptic_plasticity2.53112196
7MP0003183_abnormal_peptide_metabolism2.46318568
8MP0009780_abnormal_chondrocyte_physiolo2.40272304
9MP0004270_analgesia2.31411308
10MP0003329_amyloid_beta_deposits2.25401884
11MP0001666_abnormal_nutrient_absorption2.16598300
12MP0002796_impaired_skin_barrier2.16064762
13MP0010678_abnormal_skin_adnexa2.15145660
14MP0003303_peritoneal_inflammation2.05468158
15MP0004885_abnormal_endolymph2.02122771
16MP0000920_abnormal_myelination2.01513563
17MP0001790_abnormal_immune_system1.98655859
18MP0005387_immune_system_phenotype1.98655859
19MP0003283_abnormal_digestive_organ1.96767177
20MP0002693_abnormal_pancreas_physiology1.95583275
21MP0004043_abnormal_pH_regulation1.92101383
22MP0003866_abnormal_defecation1.90497785
23MP0003705_abnormal_hypodermis_morpholog1.90155216
24MP0000462_abnormal_digestive_system1.89557971
25MP0001944_abnormal_pancreas_morphology1.87463494
26MP0000013_abnormal_adipose_tissue1.83980325
27MP0003635_abnormal_synaptic_transmissio1.73548174
28MP0003123_paternal_imprinting1.69769881
29MP0000003_abnormal_adipose_tissue1.67962715
30MP0001765_abnormal_ion_homeostasis1.67908885
31MP0000778_abnormal_nervous_system1.61392529
32MP0002234_abnormal_pharynx_morphology1.58535056
33MP0008569_lethality_at_weaning1.56431674
34MP0000383_abnormal_hair_follicle1.56171574
35MP0000579_abnormal_nail_morphology1.55508604
36MP0000566_synostosis1.54619332
37MP0005310_abnormal_salivary_gland1.54426773
38MP0003045_fibrosis1.54222196
39MP0004947_skin_inflammation1.52018765
40MP0008260_abnormal_autophagy1.48507936
41MP0001800_abnormal_humoral_immune1.47920738
42MP0001873_stomach_inflammation1.47318898
43MP0002877_abnormal_melanocyte_morpholog1.46032286
44MP0009840_abnormal_foam_cell1.45552986
45MP0001188_hyperpigmentation1.44690454
46MP0003172_abnormal_lysosome_physiology1.43473918
47MP0003787_abnormal_imprinting1.43129017
48MP0001664_abnormal_digestion1.41763013
49MP0003868_abnormal_feces_composition1.37118346
50MP0004381_abnormal_hair_follicle1.36609677
51MP0003880_abnormal_central_pattern1.36578697
52MP0002249_abnormal_larynx_morphology1.34230020
53MP0001968_abnormal_touch/_nociception1.33451137
54MP0002822_catalepsy1.32500188
55MP0000467_abnormal_esophagus_morphology1.28804868
56MP0000465_gastrointestinal_hemorrhage1.27136361
57MP0005360_urolithiasis1.26450627
58MP0004811_abnormal_neuron_physiology1.25096856
59MP0000685_abnormal_immune_system1.24281633
60MP0004858_abnormal_nervous_system1.23954252
61MP0005220_abnormal_exocrine_pancreas1.23931204
62MP0003453_abnormal_keratinocyte_physiol1.22670251
63MP0001486_abnormal_startle_reflex1.21834949
64MP0002254_reproductive_system_inflammat1.19670631
65MP0002735_abnormal_chemical_nociception1.18365824
66MP0005451_abnormal_body_composition1.17868550
67MP0004264_abnormal_extraembryonic_tissu1.17477003
68MP0002064_seizures1.17313482
69MP0009745_abnormal_behavioral_response1.17287353
70MP0005670_abnormal_white_adipose1.16049942
71MP0005501_abnormal_skin_physiology1.14933044
72MP0005666_abnormal_adipose_tissue1.13840343
73MP0002882_abnormal_neuron_morphology1.13146391
74MP0003763_abnormal_thymus_physiology1.12780618
75MP0002089_abnormal_postnatal_growth/wei1.11990717
76MP0001849_ear_inflammation1.11332368
77MP0004185_abnormal_adipocyte_glucose1.10020215
78MP0005375_adipose_tissue_phenotype1.09456831
79MP0008874_decreased_physiological_sensi1.08446412
80MP0002138_abnormal_hepatobiliary_system1.08223342
81MP0002063_abnormal_learning/memory/cond1.06291560
82MP0004130_abnormal_muscle_cell1.05814939
83MP0001501_abnormal_sleep_pattern1.03975369
84MP0002066_abnormal_motor_capabilities/c1.03431639
85MP0002272_abnormal_nervous_system1.03361301
86MP0002078_abnormal_glucose_homeostasis1.01934901
87MP0005076_abnormal_cell_differentiation0.98306602
88MP0002572_abnormal_emotion/affect_behav0.98263352
89MP0005423_abnormal_somatic_nervous0.97989871
90MP0003191_abnormal_cellular_cholesterol0.97353088
91MP0001216_abnormal_epidermal_layer0.97184820
92MP0009643_abnormal_urine_homeostasis0.96655382
93MP0000604_amyloidosis0.96216783
94MP0002098_abnormal_vibrissa_morphology0.95907892
95MP0002067_abnormal_sensory_capabilities0.95445455
96MP0003632_abnormal_nervous_system0.95415685
97MP0004782_abnormal_surfactant_physiolog0.94814946
98MP0005645_abnormal_hypothalamus_physiol0.91474176
99MP0003631_nervous_system_phenotype0.90825755
100MP0000955_abnormal_spinal_cord0.90040162
101MP0005379_endocrine/exocrine_gland_phen0.89382798
102MP0002734_abnormal_mechanical_nocicepti0.88636209
103MP0009379_abnormal_foot_pigmentation0.88347559
104MP0005381_digestive/alimentary_phenotyp0.87857303
105MP0003633_abnormal_nervous_system0.87821680
106MP0010771_integument_phenotype0.87533944
107MP0000613_abnormal_salivary_gland0.87199481
108MP0002733_abnormal_thermal_nociception0.86433726
109MP0003252_abnormal_bile_duct0.86350619
110MP0004510_myositis0.85874760
111MP0002928_abnormal_bile_duct0.85620391
112MP0005535_abnormal_body_temperature0.85377511
113MP0002557_abnormal_social/conspecific_i0.85009866
114MP0002152_abnormal_brain_morphology0.84921154
115MP0004742_abnormal_vestibular_system0.84123797
116MP0003690_abnormal_glial_cell0.83675913
117MP0005083_abnormal_biliary_tract0.83398014
118MP0004924_abnormal_behavior0.83010637
119MP0005386_behavior/neurological_phenoty0.83010637
120MP0005000_abnormal_immune_tolerance0.80871690
121MP0003091_abnormal_cell_migration0.79971415
122MP0002723_abnormal_immune_serum0.77252318
123MP0002184_abnormal_innervation0.76253403
124MP0003879_abnormal_hair_cell0.74937042
125MP0000537_abnormal_urethra_morphology0.74858052
126MP0003634_abnormal_glial_cell0.74837382
127MP0000678_abnormal_parathyroid_gland0.74517650
128MP0002136_abnormal_kidney_physiology0.74462267
129MP0000470_abnormal_stomach_morphology0.74412533
130MP0002452_abnormal_antigen_presenting0.74078126
131MP0002229_neurodegeneration0.73973369
132MP0001502_abnormal_circadian_rhythm0.72579277
133MP0005058_abnormal_lysosome_morphology0.72289056
134MP0010155_abnormal_intestine_physiology0.71932444
135MP0002420_abnormal_adaptive_immunity0.71363621
136MP0005167_abnormal_blood-brain_barrier0.71153655
137MP0001970_abnormal_pain_threshold0.70798187
138MP0002118_abnormal_lipid_homeostasis0.70233633
139MP0001440_abnormal_grooming_behavior0.69352089
140MP0002736_abnormal_nociception_after0.69338778
141MP0006072_abnormal_retinal_apoptosis0.68956229
142MP0000377_abnormal_hair_follicle0.67356061
143MP0002069_abnormal_eating/drinking_beha0.66132748
144MP0001348_abnormal_lacrimal_gland0.65940397
145MP0001986_abnormal_taste_sensitivity0.64959992
146MP0001905_abnormal_dopamine_level0.64352203
147MP0006276_abnormal_autonomic_nervous0.63587404

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)5.00703283
2Agammaglobulinemia (HP:0004432)4.54880137
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.24148540
4Colitis (HP:0002583)3.76939836
5Gastrointestinal stroma tumor (HP:0100723)3.72908523
6Abnormal delayed hypersensitivity skin test (HP:0002963)3.59676085
7Inflammation of the large intestine (HP:0002037)3.41003097
8Peripheral hypomyelination (HP:0007182)3.36377844
9Gastrointestinal inflammation (HP:0004386)3.35560741
10Broad face (HP:0000283)3.28382507
11Papilloma (HP:0012740)3.24333547
12Verrucae (HP:0200043)3.24333547
13Neurofibrillary tangles (HP:0002185)3.15611409
14Supranuclear gaze palsy (HP:0000605)3.05642398
15Recurrent bronchitis (HP:0002837)3.05104597
16Increased IgE level (HP:0003212)2.87413263
17Hyperinsulinemic hypoglycemia (HP:0000825)2.83729189
18Upper limb amyotrophy (HP:0009129)2.81204993
19Distal upper limb amyotrophy (HP:0007149)2.81204993
20Cerebral inclusion bodies (HP:0100314)2.71557320
21Bronchomalacia (HP:0002780)2.71523523
22Thin bony cortex (HP:0002753)2.67141581
23Growth hormone excess (HP:0000845)2.63445607
24Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.62936403
25Interstitial pulmonary disease (HP:0006530)2.60380946
26Germ cell neoplasia (HP:0100728)2.60365915
27Intention tremor (HP:0002080)2.60135177
28Ankle clonus (HP:0011448)2.55344757
29Abnormality of calcium-phosphate metabolism (HP:0100530)2.54311281
30Cellulitis (HP:0100658)2.51476120
31Stridor (HP:0010307)2.51164470
32Recurrent sinusitis (HP:0011108)2.49966704
33Abnormality of the pancreatic islet cells (HP:0006476)2.49617102
34Abnormality of endocrine pancreas physiology (HP:0012093)2.49617102
35Chronic otitis media (HP:0000389)2.48764189
36Ventricular fibrillation (HP:0001663)2.47183554
37Milia (HP:0001056)2.46206854
38Increased circulating renin level (HP:0000848)2.43916348
39Action tremor (HP:0002345)2.43238395
40Megalencephaly (HP:0001355)2.41959675
41Ankyloglossia (HP:0010296)2.41499824
42Spastic gait (HP:0002064)2.38095088
43Macroorchidism (HP:0000053)2.38067402
44Neuronal loss in central nervous system (HP:0002529)2.37029158
45J-shaped sella turcica (HP:0002680)2.36533665
46Abnormality of renin-angiotensin system (HP:0000847)2.35728741
47Diplopia (HP:0000651)2.35396683
48Abnormality of binocular vision (HP:0011514)2.35396683
49Abnormality of small intestinal villus morphology (HP:0011472)2.34075514
50Villous atrophy (HP:0011473)2.34075514
51Small epiphyses (HP:0010585)2.32459536
52Sleep apnea (HP:0010535)2.30204824
53Hemorrhage of the eye (HP:0011885)2.29926464
54Distal lower limb amyotrophy (HP:0008944)2.29239764
55Hypoglycemic seizures (HP:0002173)2.28124584
56Lower limb amyotrophy (HP:0007210)2.27908872
57Onycholysis (HP:0001806)2.27564710
58Papilledema (HP:0001085)2.26794359
59Cerebral aneurysm (HP:0004944)2.25121957
60Vertebral arch anomaly (HP:0008438)2.24165364
61Symptomatic seizures (HP:0011145)2.23630615
62Deep palmar crease (HP:0006191)2.22758127
63Emphysema (HP:0002097)2.20540237
64Hand muscle atrophy (HP:0009130)2.20263870
65Panhypogammaglobulinemia (HP:0003139)2.19759781
66Epileptic encephalopathy (HP:0200134)2.19441587
67Large for gestational age (HP:0001520)2.19419749
68Fragile nails (HP:0001808)2.17699247
69Late onset (HP:0003584)2.16451593
70Bronchitis (HP:0012387)2.16194252
71Onion bulb formation (HP:0003383)2.15615683
72Truncal ataxia (HP:0002078)2.13412376
73Barrel-shaped chest (HP:0001552)2.12747311
74Hyperparathyroidism (HP:0000843)2.11976676
75Lymphangioma (HP:0100764)2.11619501
76Decreased circulating renin level (HP:0003351)2.09651670
77Hyperactive renin-angiotensin system (HP:0000841)2.08195061
78Metabolic alkalosis (HP:0200114)2.08183247
79Dehydration (HP:0001944)2.06361775
80Ketoacidosis (HP:0001993)2.06063603
81Scanning speech (HP:0002168)2.05809445
82Spinal canal stenosis (HP:0003416)2.04929072
83Annular pancreas (HP:0001734)2.04549136
84Hypokalemic alkalosis (HP:0001949)2.04246844
85Abnormal eating behavior (HP:0100738)2.03165697
86Urinary bladder sphincter dysfunction (HP:0002839)2.02490717
87Abnormality of oral frenula (HP:0000190)2.02398522
88Dysmetria (HP:0001310)2.02030752
89Focal seizures (HP:0007359)2.00814354
90Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.00556529
91Degeneration of the lateral corticospinal tracts (HP:0002314)2.00556529
92Akinesia (HP:0002304)2.00220991
93IgM deficiency (HP:0002850)1.99591231
94Premature skin wrinkling (HP:0100678)1.99254294
95Rapidly progressive (HP:0003678)1.98834860
96Urinary urgency (HP:0000012)1.98612351
97Foot dorsiflexor weakness (HP:0009027)1.98408887
98Pointed chin (HP:0000307)1.96463324
99Abnormality of chloride homeostasis (HP:0011422)1.93720167
100Recurrent otitis media (HP:0000403)1.93671380
101Distal sensory impairment (HP:0002936)1.93624722
102Shallow orbits (HP:0000586)1.93447560
103Resting tremor (HP:0002322)1.93176642
104Mitral stenosis (HP:0001718)1.92686409
105Visceral angiomatosis (HP:0100761)1.92460715
106Plantar hyperkeratosis (HP:0007556)1.91607879
107Sepsis (HP:0100806)1.90977157
108Restrictive lung disease (HP:0002091)1.90781830
109Thickened helices (HP:0000391)1.89993585
110Bowel incontinence (HP:0002607)1.89652787
111Postural instability (HP:0002172)1.88854610
112Torticollis (HP:0000473)1.87921137
113Hyperkalemia (HP:0002153)1.86023372
114Gout (HP:0001997)1.85521230
115Sensory axonal neuropathy (HP:0003390)1.85422882
116Clonus (HP:0002169)1.85300050
117Visual hallucinations (HP:0002367)1.84562611
118Insomnia (HP:0100785)1.83917616
119Abnormality of the lower motor neuron (HP:0002366)1.82797658
120Meningitis (HP:0001287)1.82497046
121Apathy (HP:0000741)1.81798365
122Limb hypertonia (HP:0002509)1.81264686
123Abnormal pancreas size (HP:0012094)1.80762681
124Cubitus valgus (HP:0002967)1.78992055
125Abnormality of the corticospinal tract (HP:0002492)1.78517584
126Dysdiadochokinesis (HP:0002075)1.77329465
127Lower limb muscle weakness (HP:0007340)1.77184553
128Turricephaly (HP:0000262)1.76542510
129Chronic sinusitis (HP:0011109)1.76154471
130Stereotypic behavior (HP:0000733)1.75713944
131Depression (HP:0000716)1.75630233
132Abdominal distention (HP:0003270)1.75536008
133Decreased motor nerve conduction velocity (HP:0003431)1.74551282
134Alacrima (HP:0000522)1.73990973
135Woolly hair (HP:0002224)1.72308090
136Malnutrition (HP:0004395)1.72210044
137Hammertoe (HP:0001765)1.72030376
138Flattened epiphyses (HP:0003071)1.71691066
139Lymphopenia (HP:0001888)1.71245854
140Focal motor seizures (HP:0011153)1.70989635
141Precocious puberty (HP:0000826)1.70845111
142Flat acetabular roof (HP:0003180)1.70776543
143Truncus arteriosus (HP:0001660)1.70062184
144Heterotopia (HP:0002282)1.70029225
145Hyperacusis (HP:0010780)1.68697245
146Abnormality of the foot musculature (HP:0001436)1.68594796
147Ulnar bowing (HP:0003031)1.68278324
148Hypercortisolism (HP:0001578)1.68160317
149Nasal polyposis (HP:0100582)1.67807409
150Difficulty climbing stairs (HP:0003551)1.67254573
151Unilateral renal agenesis (HP:0000122)1.67046711
152Abnormality of nail color (HP:0100643)1.67016386
153Myokymia (HP:0002411)1.66927067
154Rigidity (HP:0002063)1.66030675
155Bundle branch block (HP:0011710)1.65277484
156Deep venous thrombosis (HP:0002625)1.65210552
157Abnormality of the gastric mucosa (HP:0004295)1.64965014
158Hemiplegia (HP:0002301)1.64436587
159Abnormality of the nasal mucosa (HP:0000433)1.64328630
160Recurrent viral infections (HP:0004429)1.63446822
161Mitral regurgitation (HP:0001653)1.63329574
162Abnormality of the fingertips (HP:0001211)1.63111143
163Neoplasm of the heart (HP:0100544)1.62712821
164Hemangiomatosis (HP:0007461)1.62200995
165Adrenal overactivity (HP:0002717)1.61760566
166Acanthosis nigricans (HP:0000956)1.61471668
167Abnormal large intestine physiology (HP:0012700)1.61205130
168Diminished motivation (HP:0000745)1.59697279
169Polar cataract (HP:0010696)1.59470575
170Lower limb asymmetry (HP:0100559)1.59112661
171Aplasia involving bones of the upper limbs (HP:0009823)1.56721300
172Aplasia of the phalanges of the hand (HP:0009802)1.56721300
173Aplasia involving bones of the extremities (HP:0009825)1.56721300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB12.72489841
2MAP4K12.69253437
3TAOK32.59330706
4PRPF4B2.50751843
5STK392.17251673
6ERN12.12825359
7MAP3K102.11379780
8MAPK152.06679648
9TRIB31.93596292
10EPHA21.90738129
11MAP3K21.86951489
12WNK41.84402532
13PRKD21.79058656
14GRK61.74661880
15PRKD31.73584678
16MST1R1.73537781
17EEF2K1.70442336
18MAP3K91.70091569
19HIPK21.68234793
20FES1.53201135
21PRKCH1.51275887
22UHMK11.50714850
23WNK11.48147500
24MAP3K11.47746481
25MARK21.45391139
26KSR21.44385420
27LRRK21.44094911
28SMG11.42309891
29TYRO31.36816505
30SIK21.36763202
31ICK1.36552596
32PTK61.32751582
33MAP3K131.31191423
34OXSR11.31098135
35TAOK11.30966607
36NTRK11.26494818
37INSRR1.26165984
38MST41.26026502
39NEK61.24516740
40FGFR21.20651526
41CDK121.16918217
42SIK11.14852299
43FGFR41.10732874
44MAP3K71.08970806
45PKN11.08312253
46SIK31.07735093
47STK111.05687423
48BTK1.03918000
49BLK1.03295659
50ALK1.03222080
51RPS6KA20.99672155
52CDC42BPA0.99365588
53RIPK10.99172144
54JAK10.97488389
55ITK0.97181549
56PRKD10.97055303
57FRK0.96380784
58SGK30.96091508
59STK380.95697111
60MAPK120.94969131
61CAMK1G0.93956133
62CSK0.93659116
63MAP3K60.93320967
64TNK20.93017364
65MAP2K20.91910481
66PAK60.90971173
67MINK10.90879082
68PAK30.89699694
69CASK0.88816655
70PRKCQ0.86364127
71TESK10.85610310
72SGK20.85421355
73TNIK0.84694203
74NTRK30.84089788
75LMTK20.84016589
76CLK10.82183048
77PDK10.81767575
78PTK20.81378886
79RET0.80729525
80PDPK10.80093898
81PDGFRA0.79575422
82RIPK40.79189756
83DYRK1B0.78608090
84STK100.78177108
85MTOR0.77699936
86PDGFRB0.77351097
87ARAF0.76913960
88CDK50.76764594
89EPHA40.76634179
90MAP3K110.75718715
91CAMKK10.75369314
92CAMK2B0.74932752
93BMX0.74806266
94SYK0.73604465
95MAPKAPK50.70185589
96FGR0.67030937
97FYN0.65575452
98PRKCZ0.64245179
99CSNK1A1L0.63446895
100MAPK100.60899791
101PKN20.60126687
102PASK0.58768687
103PHKG10.58744842
104PHKG20.58744842
105MAP2K40.56137274
106PRKG20.56103655
107DAPK20.55601044
108ERBB20.54510124
109CDK190.54026477
110IRAK20.53922969
111JAK20.53039940
112HCK0.52700747
113DMPK0.52514728
114EPHA30.52508603
115SGK2230.52221515
116SGK4940.52221515
117MET0.52038929
118CAMK2G0.51698445
119IRAK10.51605463
120FER0.51245451
121MARK10.50795072
122FGFR30.50751431
123MAPKAPK30.50308718
124MAP2K60.50149182
125DYRK1A0.49980281
126CAMK10.48721636
127JAK30.46822261
128PRKCI0.46362418
129GRK10.46189791
130MAPK80.44573851
131NTRK20.43982994
132MAPK110.43430903
133MAP2K10.43372472
134CAMK40.42153979
135ROCK20.41908828
136SGK10.41720739
137PRKAA10.40149567
138MAPK130.38233134

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.23071152
2B cell receptor signaling pathway_Homo sapiens_hsa046622.24969844
3Insulin secretion_Homo sapiens_hsa049111.92129566
4Pancreatic secretion_Homo sapiens_hsa049721.86325378
5Primary immunodeficiency_Homo sapiens_hsa053401.81193805
6Gastric acid secretion_Homo sapiens_hsa049711.61983394
7Cyanoamino acid metabolism_Homo sapiens_hsa004601.59476404
8Notch signaling pathway_Homo sapiens_hsa043301.54802674
9Long-term potentiation_Homo sapiens_hsa047201.54184158
10Carbohydrate digestion and absorption_Homo sapiens_hsa049731.54123531
11Type II diabetes mellitus_Homo sapiens_hsa049301.52186320
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52046833
13Phosphatidylinositol signaling system_Homo sapiens_hsa040701.48368779
14Dorso-ventral axis formation_Homo sapiens_hsa043201.44348708
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42979471
16Nitrogen metabolism_Homo sapiens_hsa009101.42471387
17Glutamatergic synapse_Homo sapiens_hsa047241.37435769
18Cocaine addiction_Homo sapiens_hsa050301.35271726
19Salivary secretion_Homo sapiens_hsa049701.33130667
20Cholinergic synapse_Homo sapiens_hsa047251.31604181
21Circadian entrainment_Homo sapiens_hsa047131.31369199
22Nicotine addiction_Homo sapiens_hsa050331.31358661
23Estrogen signaling pathway_Homo sapiens_hsa049151.28477035
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25475772
25GnRH signaling pathway_Homo sapiens_hsa049121.22872266
26Amphetamine addiction_Homo sapiens_hsa050311.20722070
27Renin secretion_Homo sapiens_hsa049241.17094653
28Morphine addiction_Homo sapiens_hsa050321.17088348
29Long-term depression_Homo sapiens_hsa047301.16871284
30Dopaminergic synapse_Homo sapiens_hsa047281.15372185
31Phospholipase D signaling pathway_Homo sapiens_hsa040721.13497847
32Histidine metabolism_Homo sapiens_hsa003401.13105493
33VEGF signaling pathway_Homo sapiens_hsa043701.13085016
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13064009
35T cell receptor signaling pathway_Homo sapiens_hsa046601.11046144
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10490077
37GABAergic synapse_Homo sapiens_hsa047271.10345457
38Sulfur metabolism_Homo sapiens_hsa009201.07068697
39Renal cell carcinoma_Homo sapiens_hsa052111.05346556
40Olfactory transduction_Homo sapiens_hsa047401.04864210
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03478445
42Fat digestion and absorption_Homo sapiens_hsa049751.03019703
43Arginine biosynthesis_Homo sapiens_hsa002201.03007621
44Choline metabolism in cancer_Homo sapiens_hsa052311.01300208
45Thyroid hormone synthesis_Homo sapiens_hsa049181.00597949
46ErbB signaling pathway_Homo sapiens_hsa040120.99983875
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99466365
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.99408711
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98451673
50Axon guidance_Homo sapiens_hsa043600.96950878
51Glioma_Homo sapiens_hsa052140.96347205
52Prion diseases_Homo sapiens_hsa050200.95598488
53Inositol phosphate metabolism_Homo sapiens_hsa005620.94459245
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94293082
55Oxytocin signaling pathway_Homo sapiens_hsa049210.93944323
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93457209
57Chemokine signaling pathway_Homo sapiens_hsa040620.93368020
58Non-small cell lung cancer_Homo sapiens_hsa052230.92247347
59Sphingolipid metabolism_Homo sapiens_hsa006000.91958702
60Endocytosis_Homo sapiens_hsa041440.91928266
61Gap junction_Homo sapiens_hsa045400.91630731
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89950813
63AMPK signaling pathway_Homo sapiens_hsa041520.89283097
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88779047
65Platelet activation_Homo sapiens_hsa046110.88107993
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87505901
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86043340
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86008566
69ABC transporters_Homo sapiens_hsa020100.85056131
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82526755
71Insulin resistance_Homo sapiens_hsa049310.81939887
72Taste transduction_Homo sapiens_hsa047420.81784731
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.81182131
74Serotonergic synapse_Homo sapiens_hsa047260.80704438
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.79767951
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79675425
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.75792267
78Other glycan degradation_Homo sapiens_hsa005110.75250023
79MAPK signaling pathway_Homo sapiens_hsa040100.74630812
80cAMP signaling pathway_Homo sapiens_hsa040240.74617004
81Protein digestion and absorption_Homo sapiens_hsa049740.74502040
82Ether lipid metabolism_Homo sapiens_hsa005650.73832064
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71929180
84Prolactin signaling pathway_Homo sapiens_hsa049170.71795750
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66262515
86Endometrial cancer_Homo sapiens_hsa052130.65702575
87Bile secretion_Homo sapiens_hsa049760.64739625
88Tight junction_Homo sapiens_hsa045300.63888089
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63216677
90Calcium signaling pathway_Homo sapiens_hsa040200.61676220
91Vibrio cholerae infection_Homo sapiens_hsa051100.58691310
92Hepatitis C_Homo sapiens_hsa051600.58336694
93Fructose and mannose metabolism_Homo sapiens_hsa000510.58025932
94Ras signaling pathway_Homo sapiens_hsa040140.57656130
95Glucagon signaling pathway_Homo sapiens_hsa049220.57151140
96Lysine degradation_Homo sapiens_hsa003100.57100820
97Melanogenesis_Homo sapiens_hsa049160.56917701
98Chronic myeloid leukemia_Homo sapiens_hsa052200.56517478
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.56449893
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56403361
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.56291045
102Acute myeloid leukemia_Homo sapiens_hsa052210.55723468
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55662386
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.54948714
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54228961
106Ovarian steroidogenesis_Homo sapiens_hsa049130.53851245
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53841821
108Rap1 signaling pathway_Homo sapiens_hsa040150.53558409
109Osteoclast differentiation_Homo sapiens_hsa043800.52835858
110Protein export_Homo sapiens_hsa030600.52122036
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51722045
112Glycerolipid metabolism_Homo sapiens_hsa005610.51205180
113Phenylalanine metabolism_Homo sapiens_hsa003600.50359078
114Hematopoietic cell lineage_Homo sapiens_hsa046400.49775778
115Synaptic vesicle cycle_Homo sapiens_hsa047210.49103955
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47903399
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47446820
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47405514
119Pancreatic cancer_Homo sapiens_hsa052120.47350885
120Insulin signaling pathway_Homo sapiens_hsa049100.47227494
121Colorectal cancer_Homo sapiens_hsa052100.47176050
122mTOR signaling pathway_Homo sapiens_hsa041500.47156558

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