HIPK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.76355906
2megakaryocyte development (GO:0035855)4.43826551
3* definitive hemopoiesis (GO:0060216)4.42174903
4leukocyte aggregation (GO:0070486)3.90314944
5cilium or flagellum-dependent cell motility (GO:0001539)3.90045423
6negative regulation of phagocytosis (GO:0050765)3.89896160
7negative regulation of erythrocyte differentiation (GO:0045647)3.88748945
8regulation of histone H3-K27 methylation (GO:0061085)3.81660232
9regulation of gamma-delta T cell differentiation (GO:0045586)3.77969561
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.72997256
11regulation of gamma-delta T cell activation (GO:0046643)3.63273344
12phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.61062516
13axonemal dynein complex assembly (GO:0070286)3.60943336
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.51025222
15negative regulation of cell killing (GO:0031342)3.51025222
16regulation of B cell receptor signaling pathway (GO:0050855)3.49083328
17positive thymic T cell selection (GO:0045059)3.40583726
18hepatocyte apoptotic process (GO:0097284)3.38702161
19histone lysine demethylation (GO:0070076)3.37937951
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.34524023
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.34524023
22mitotic sister chromatid cohesion (GO:0007064)3.34235989
23embryonic hemopoiesis (GO:0035162)3.33404268
24positive T cell selection (GO:0043368)3.32578633
25histone demethylation (GO:0016577)3.25764541
26antigen processing and presentation of endogenous antigen (GO:0019883)3.24602271
27regulation of interferon-beta biosynthetic process (GO:0045357)3.19679867
28positive regulation of histone deacetylation (GO:0031065)3.17513984
29positive regulation of B cell differentiation (GO:0045579)3.10300601
30tolerance induction (GO:0002507)3.07775239
31glucocorticoid receptor signaling pathway (GO:0042921)3.06123249
32histone H3-K36 demethylation (GO:0070544)3.06094386
33histone H3-K9 demethylation (GO:0033169)3.06039586
34regulation of interleukin-5 production (GO:0032674)3.05087563
35regulation of interleukin-12 biosynthetic process (GO:0045075)3.02820330
36negative T cell selection (GO:0043383)3.01358093
37regulation of B cell differentiation (GO:0045577)2.98712800
38striated muscle atrophy (GO:0014891)2.97950226
39histone H3-K4 trimethylation (GO:0080182)2.96463047
40response to peptidoglycan (GO:0032494)2.95385117
41leukocyte cell-cell adhesion (GO:0007159)2.90369070
42myeloid cell development (GO:0061515)2.89976499
43positive regulation of tolerance induction (GO:0002645)2.88655460
44positive regulation by organism of defense response of other organism involved in symbiotic interact2.86818973
45modulation by symbiont of host immune response (GO:0052553)2.86818973
46positive regulation by symbiont of host defense response (GO:0052509)2.86818973
47modulation by symbiont of host defense response (GO:0052031)2.86818973
48modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.86818973
49modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.86818973
50interferon-gamma production (GO:0032609)2.85972946
51response to interleukin-15 (GO:0070672)2.85269384
52skeletal muscle adaptation (GO:0043501)2.83539998
53cytoplasmic mRNA processing body assembly (GO:0033962)2.82627332
54cellular extravasation (GO:0045123)2.82505142
55negative thymic T cell selection (GO:0045060)2.81205226
56detection of molecule of bacterial origin (GO:0032490)2.81074667
57positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.79903521
58negative regulation of inclusion body assembly (GO:0090084)2.78927115
59angiogenesis involved in wound healing (GO:0060055)2.78249275
60corticosteroid receptor signaling pathway (GO:0031958)2.77667894
61regulation of ARF protein signal transduction (GO:0032012)2.77642700
62regulation of interleukin-13 production (GO:0032656)2.77200271
63protein demethylation (GO:0006482)2.75015775
64protein dealkylation (GO:0008214)2.75015775
65erythrocyte maturation (GO:0043249)2.74935956
66positive regulation of keratinocyte differentiation (GO:0045618)2.74919044
67negative regulation of granulocyte differentiation (GO:0030853)2.72324258
68negative regulation of lymphocyte mediated immunity (GO:0002707)2.71984978
69CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.70478286
70T-helper cell differentiation (GO:0042093)2.70478286
71retrograde transport, vesicle recycling within Golgi (GO:0000301)2.70136584
72regulation of establishment of cell polarity (GO:2000114)2.70088131
73thrombin receptor signaling pathway (GO:0070493)2.69433405
74regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.69035001
75B cell receptor signaling pathway (GO:0050853)2.68603456
76leukocyte tethering or rolling (GO:0050901)2.68425580
77positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.68181108
78T cell selection (GO:0045058)2.68114640
79macrophage activation (GO:0042116)2.66406676
80embryonic process involved in female pregnancy (GO:0060136)2.65627165
81regulation of tolerance induction (GO:0002643)2.65512943
82positive regulation of mRNA catabolic process (GO:0061014)2.64819184
83regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.64682130
84neutrophil activation involved in immune response (GO:0002283)2.64350178
85microglial cell activation (GO:0001774)2.64274870
86positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.63792940
87regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.63792940
88detection of other organism (GO:0098543)2.63662817
89JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.63043830
90cilium movement (GO:0003341)2.62003624
91positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.61822040
92macrophage activation involved in immune response (GO:0002281)2.61564599
93monocyte differentiation (GO:0030224)2.60729332
94myeloid dendritic cell activation (GO:0001773)2.59507585
95cellular response to zinc ion (GO:0071294)2.57795686
96negative regulation of T cell mediated immunity (GO:0002710)2.57451385
97negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.56759804
98nuclear pore complex assembly (GO:0051292)2.56566895
99regulation of germinal center formation (GO:0002634)2.56219596
100dendritic cell chemotaxis (GO:0002407)2.55713873
101positive regulation of granulocyte differentiation (GO:0030854)2.55228248
102motile cilium assembly (GO:0044458)2.54045675
103thymic T cell selection (GO:0045061)2.53622670
104epithelial cell differentiation involved in prostate gland development (GO:0060742)2.51076949
105establishment of endothelial barrier (GO:0061028)2.50736006
106B cell homeostasis (GO:0001782)2.48659350
107lymphocyte homeostasis (GO:0002260)2.48183343
108positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.44663656
109peptidyl-lysine trimethylation (GO:0018023)2.44635371
110negative regulation of immunoglobulin mediated immune response (GO:0002890)2.44270350
111negative regulation of B cell mediated immunity (GO:0002713)2.44270350
112protein targeting to Golgi (GO:0000042)2.43006425
113dendritic cell migration (GO:0036336)2.42905449
114positive regulation of protein deacetylation (GO:0090312)2.42890201
115regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.42676070
116regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.42584679
117cellular response to ethanol (GO:0071361)2.42495779
118positive regulation of erythrocyte differentiation (GO:0045648)2.42113483
119neutrophil activation (GO:0042119)2.41588109
120peptidyl-threonine phosphorylation (GO:0018107)2.41342140
121detection of external biotic stimulus (GO:0098581)2.40269033
122erythrocyte development (GO:0048821)2.39921739
123regulation of DNA endoreduplication (GO:0032875)2.39290024
124Golgi to endosome transport (GO:0006895)2.37621861
125growth hormone receptor signaling pathway (GO:0060396)2.37088190
126establishment of protein localization to Golgi (GO:0072600)2.36469085
127hypotonic response (GO:0006971)2.36398380
128granulocyte activation (GO:0036230)2.35147993
129protoporphyrinogen IX metabolic process (GO:0046501)2.35033380
130neutrophil mediated immunity (GO:0002446)2.34118735
131regulation of mRNA catabolic process (GO:0061013)2.33878216
132regulation of erythrocyte differentiation (GO:0045646)2.32032460
133response to host defenses (GO:0052200)2.28245295
134response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.28245295
135response to host (GO:0075136)2.28245295
136negative regulation of B cell proliferation (GO:0030889)2.26865660
137response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.25345360
138response to host immune response (GO:0052572)2.25345360
139response to muramyl dipeptide (GO:0032495)2.23511948
140histone mRNA catabolic process (GO:0071044)2.23417004
141positive regulation of protein import into nucleus, translocation (GO:0033160)2.23401946
142protoporphyrinogen IX biosynthetic process (GO:0006782)2.22737207
143germinal center formation (GO:0002467)2.21723964
144interferon-gamma-mediated signaling pathway (GO:0060333)2.20692687
145fibroblast migration (GO:0010761)2.20099525
146germ cell migration (GO:0008354)2.19687519
147regulation of granulocyte differentiation (GO:0030852)2.19632551
148regulation of histone deacetylation (GO:0031063)2.18854286
149cellular response to interleukin-15 (GO:0071350)2.16153972

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.24116626
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.94277901
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.84343007
4E2F7_22180533_ChIP-Seq_HELA_Human3.20069143
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.19357515
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.92297016
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.88321904
8SCL_19346495_ChIP-Seq_HPC-7_Human2.85759765
9* RUNX_20019798_ChIP-Seq_JUKART_Human2.73389142
10GATA1_22025678_ChIP-Seq_K562_Human2.72267839
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.71554039
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.69417810
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.68312456
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.63300276
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.55560717
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.50460980
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47010127
18* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.44916639
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.37406466
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.33247210
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28494532
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21554422
23ESR2_21235772_ChIP-Seq_MCF-7_Human2.10997384
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.10098126
25MYB_26560356_Chip-Seq_TH2_Human2.05542281
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.03204510
27BP1_19119308_ChIP-ChIP_Hs578T_Human2.01564168
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.87884065
29RUNX1_27514584_Chip-Seq_MCF-7_Human1.85563166
30MYC_22102868_ChIP-Seq_BL_Human1.82030802
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.80677263
32TCF7_22412390_ChIP-Seq_EML_Mouse1.79646951
33MYB_26560356_Chip-Seq_TH1_Human1.78991370
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78970449
35MAF_26560356_Chip-Seq_TH1_Human1.69501993
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68674707
37GATA1_19941826_ChIP-Seq_K562_Human1.68107777
38GATA2_19941826_ChIP-Seq_K562_Human1.63712351
39TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.58433914
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57184764
41PKCTHETA_26484144_Chip-Seq_BREAST_Human1.50647067
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49621842
43SPI1_23127762_ChIP-Seq_K562_Human1.47391713
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46647193
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45622920
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45018598
47* GATA3_27048872_Chip-Seq_THYMUS_Human1.44167087
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.44075293
49* GATA1_19941827_ChIP-Seq_MEL_Mouse1.43446289
50* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39939517
51VDR_24787735_ChIP-Seq_THP-1_Human1.39822600
52PU_27001747_Chip-Seq_BMDM_Mouse1.39529005
53VDR_24763502_ChIP-Seq_THP-1_Human1.37358832
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32727758
55* UTX_26944678_Chip-Seq_JUKART_Human1.31999471
56* ER_23166858_ChIP-Seq_MCF-7_Human1.30293681
57* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.28877709
58SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28123195
59* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25668903
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24901753
61FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24394803
62* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24236261
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23990864
64GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21082277
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20395616
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19803513
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18606139
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17670074
69VDR_21846776_ChIP-Seq_THP-1_Human1.17598516
70RXR_22108803_ChIP-Seq_LS180_Human1.15216533
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14048965
72KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.12523112
73GATA1_19941827_ChIP-Seq_MEL86_Mouse1.11896537
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11562365
75KDM2B_26808549_Chip-Seq_K562_Human1.10938494
76* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10458207
77ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10009125
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09008171
79* ESR1_20079471_ChIP-ChIP_T-47D_Human1.08909925
80FOXO3_23340844_ChIP-Seq_DLD1_Human1.08884629
81CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08153642
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07556841
83ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06782484
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.05988928
85SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05535106
86SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05535106
87RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05136005
88AHR_22903824_ChIP-Seq_MCF-7_Human1.04696399
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04627945
90TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03589156
91GATA3_26560356_Chip-Seq_TH2_Human1.03107893
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.02543192
93GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02388204
94CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01900893
95KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01146110
96FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01012856
97KDM2B_26808549_Chip-Seq_DND41_Human1.00183860
98* SPI1_23547873_ChIP-Seq_NB4_Human0.99402523
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98363691
100* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94241338
101MAF_26560356_Chip-Seq_TH2_Human0.93796435
102FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92949374
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92845141
104CLOCK_20551151_ChIP-Seq_293T_Human0.92479644
105DROSHA_22980978_ChIP-Seq_HELA_Human0.92444886
106RACK7_27058665_Chip-Seq_MCF-7_Human0.92048900
107LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91891551
108NCOR1_26117541_ChIP-Seq_K562_Human0.91826582
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90424783
110PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89194670
111STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88786373
112SMRT_27268052_Chip-Seq_Bcells_Human0.88767574
113PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88676038
114TDRD3_21172665_ChIP-Seq_MCF-7_Human0.87949568
115GATA3_24758297_ChIP-Seq_MCF-7_Human0.87801638
116FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87358105
117FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87137449
118EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87062802
119CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86970294
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85635229
121BRD4_25478319_ChIP-Seq_HGPS_Human0.85275260
122CJUN_26792858_Chip-Seq_BT549_Human0.84978455
123MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.84663618
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84094491
125TBX20_22328084_ChIP-Seq_HEART_Mouse0.83685342
126TBX20_22080862_ChIP-Seq_HEART_Mouse0.83685342
127* KDM2B_26808549_Chip-Seq_JURKAT_Human0.82917290
128* FOXA2_19822575_ChIP-Seq_HepG2_Human0.82727398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer2.98992430
2MP0004808_abnormal_hematopoietic_stem2.89354078
3MP0004147_increased_porphyrin_level2.87454771
4MP0001835_abnormal_antigen_presentation2.79419861
5MP0003303_peritoneal_inflammation2.78199303
6MP0005397_hematopoietic_system_phenotyp2.76141888
7MP0001545_abnormal_hematopoietic_system2.76141888
8MP0002396_abnormal_hematopoietic_system2.68005935
9MP0009278_abnormal_bone_marrow2.59475691
10MP0000569_abnormal_digit_pigmentation2.45851545
11MP0004381_abnormal_hair_follicle2.42804097
12MP0002166_altered_tumor_susceptibility2.29698796
13MP0001790_abnormal_immune_system2.29298476
14MP0005387_immune_system_phenotype2.29298476
15MP0001800_abnormal_humoral_immune2.16039211
16MP0005671_abnormal_response_to2.11115662
17MP0005409_darkened_coat_color2.10774833
18MP0003436_decreased_susceptibility_to2.08873388
19MP0003763_abnormal_thymus_physiology1.99667648
20MP0006054_spinal_hemorrhage1.97174590
21MP0002398_abnormal_bone_marrow1.96704195
22MP0000685_abnormal_immune_system1.96560839
23MP0005464_abnormal_platelet_physiology1.95476637
24MP0002452_abnormal_antigen_presenting1.94353384
25MP0003656_abnormal_erythrocyte_physiolo1.91522968
26MP0009785_altered_susceptibility_to1.87886758
27MP0003943_abnormal_hepatobiliary_system1.87038025
28MP0008260_abnormal_autophagy1.87022043
29MP0002420_abnormal_adaptive_immunity1.85732573
30MP0002419_abnormal_innate_immunity1.85652959
31MP0001819_abnormal_immune_cell1.83265810
32MP0002006_tumorigenesis1.81377736
33MP0005076_abnormal_cell_differentiation1.80745274
34MP0002405_respiratory_system_inflammati1.77580213
35MP0002877_abnormal_melanocyte_morpholog1.77059125
36MP0005000_abnormal_immune_tolerance1.75603896
37MP0003172_abnormal_lysosome_physiology1.71999266
38MP0001873_stomach_inflammation1.70836917
39MP0010352_gastrointestinal_tract_polyps1.69481311
40MP0010234_abnormal_vibrissa_follicle1.69353329
41MP0002723_abnormal_immune_serum1.68241539
42MP0001879_abnormal_lymphatic_vessel1.65184271
43MP0005025_abnormal_response_to1.64254127
44MP0005451_abnormal_body_composition1.63728213
45MP0000716_abnormal_immune_system1.60069110
46MP0010155_abnormal_intestine_physiology1.56719942
47MP0003566_abnormal_cell_adhesion1.50998067
48MP0003724_increased_susceptibility_to1.50880048
49MP0002796_impaired_skin_barrier1.50498984
50MP0000689_abnormal_spleen_morphology1.49774331
51MP0003828_pulmonary_edema1.49553099
52MP0010307_abnormal_tumor_latency1.49494212
53MP0002722_abnormal_immune_system1.46039439
54MP0002132_abnormal_respiratory_system1.45773172
55MP0010678_abnormal_skin_adnexa1.40708664
56MP0003045_fibrosis1.40525620
57MP0001853_heart_inflammation1.40321170
58MP0002429_abnormal_blood_cell1.37797109
59MP0002928_abnormal_bile_duct1.37075996
60MP0000703_abnormal_thymus_morphology1.35504511
61MP0000383_abnormal_hair_follicle1.35113331
62MP0001533_abnormal_skeleton_physiology1.33094159
63MP0003787_abnormal_imprinting1.32750909
64MP0004883_abnormal_blood_vessel1.32345139
65MP0001845_abnormal_inflammatory_respons1.32114102
66MP0004185_abnormal_adipocyte_glucose1.28524153
67MP0008961_abnormal_basal_metabolism1.28278190
68MP0003453_abnormal_keratinocyte_physiol1.27582673
69MP0002148_abnormal_hypersensitivity_rea1.26839874
70MP0004947_skin_inflammation1.23219400
71MP0001958_emphysema1.20033476
72MP0001851_eye_inflammation1.19244493
73MP0002009_preneoplasia1.17482593
74MP0004264_abnormal_extraembryonic_tissu1.17201382
75MP0000465_gastrointestinal_hemorrhage1.16349932
76MP0003091_abnormal_cell_migration1.13110251
77MP0004484_altered_response_of1.12665151
78MP0008995_early_reproductive_senescence1.12264213
79MP0000858_altered_metastatic_potential1.10255370
80MP0010368_abnormal_lymphatic_system1.10058275
81MP0003279_aneurysm1.07771918
82MP0005083_abnormal_biliary_tract1.05771918
83MP0003183_abnormal_peptide_metabolism1.05324701
84MP0003705_abnormal_hypodermis_morpholog1.01070851
85MP0005666_abnormal_adipose_tissue0.99740036
86MP0009115_abnormal_fat_cell0.99535095
87MP0009764_decreased_sensitivity_to0.99310499
88MP0004782_abnormal_surfactant_physiolog0.98528614
89MP0003448_altered_tumor_morphology0.98287443
90MP0003690_abnormal_glial_cell0.97327054
91MP0002332_abnormal_exercise_endurance0.97279481
92MP0000767_abnormal_smooth_muscle0.97206350
93MP0002998_abnormal_bone_remodeling0.95390282
94MP0000343_altered_response_to0.93721981
95MP0005075_abnormal_melanosome_morpholog0.93439052
96MP0005621_abnormal_cell_physiology0.92086854
97MP0004510_myositis0.89887818
98MP0004233_abnormal_muscle_weight0.86595000
99MP0005377_hearing/vestibular/ear_phenot0.86243314
100MP0003878_abnormal_ear_physiology0.86243314
101MP0009780_abnormal_chondrocyte_physiolo0.86093152
102MP0003866_abnormal_defecation0.85761983
103MP0003191_abnormal_cellular_cholesterol0.85738407
104MP0005023_abnormal_wound_healing0.85459630
105MP0005310_abnormal_salivary_gland0.85231953
106MP0002933_joint_inflammation0.84485138
107MP0008057_abnormal_DNA_replication0.84100435
108MP0005388_respiratory_system_phenotype0.84070733
109MP0002133_abnormal_respiratory_system0.84070733
110MP0006082_CNS_inflammation0.83781636
111MP0004130_abnormal_muscle_cell0.82879140
112MP0002277_abnormal_respiratory_mucosa0.82714588
113MP0001915_intracranial_hemorrhage0.82647848
114MP0002925_abnormal_cardiovascular_devel0.78427282
115MP0009703_decreased_birth_body0.77641591
116MP0003221_abnormal_cardiomyocyte_apopto0.75339847
117MP0008007_abnormal_cellular_replicative0.75264410
118MP0005167_abnormal_blood-brain_barrier0.74477085
119MP0002060_abnormal_skin_morphology0.74112913
120MP0010630_abnormal_cardiac_muscle0.71855964
121MP0000490_abnormal_crypts_of0.71734394
122MP0000015_abnormal_ear_pigmentation0.71519294
123MP0009333_abnormal_splenocyte_physiolog0.70153439
124MP0005164_abnormal_response_to0.68890084
125MP0000627_abnormal_mammary_gland0.68245004
126MP0003795_abnormal_bone_structure0.68225039
127MP0005390_skeleton_phenotype0.67992763
128MP0008004_abnormal_stomach_pH0.67714315
129MP0002168_other_aberrant_phenotype0.67192265

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.75917789
2Absent/shortened dynein arms (HP:0200106)3.85132000
3Dynein arm defect of respiratory motile cilia (HP:0012255)3.85132000
4Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.50148761
5Papillary thyroid carcinoma (HP:0002895)3.48944840
6Eczematoid dermatitis (HP:0000976)3.48909399
7Abnormal respiratory motile cilium morphology (HP:0005938)3.32731108
8Abnormal respiratory epithelium morphology (HP:0012253)3.32731108
9Recurrent abscess formation (HP:0002722)3.17301544
10Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.10499229
11Recurrent viral infections (HP:0004429)3.01410785
12Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.94561261
13Cellulitis (HP:0100658)2.90906765
14Recurrent fungal infections (HP:0002841)2.89573628
15Acute myeloid leukemia (HP:0004808)2.89336173
16Spinal cord lesions (HP:0100561)2.85983854
17Syringomyelia (HP:0003396)2.85983854
18Abnormality of the frontal sinuses (HP:0002687)2.82175823
19Recurrent bacterial skin infections (HP:0005406)2.72636365
20T lymphocytopenia (HP:0005403)2.70962967
21Poikilocytosis (HP:0004447)2.69489292
22Autoimmune thrombocytopenia (HP:0001973)2.69301606
23Nasal polyposis (HP:0100582)2.68370395
24Hematochezia (HP:0002573)2.68287356
25Absent frontal sinuses (HP:0002688)2.63785338
26Volvulus (HP:0002580)2.60558687
27Recurrent bronchitis (HP:0002837)2.55790701
28Germ cell neoplasia (HP:0100728)2.55130765
29Agammaglobulinemia (HP:0004432)2.54741575
30Abnormality of T cell number (HP:0011839)2.53787695
31Myositis (HP:0100614)2.51089753
32Aortic aneurysm (HP:0004942)2.50748724
33Slow saccadic eye movements (HP:0000514)2.50578029
34Thyroid carcinoma (HP:0002890)2.49345096
35Obstructive sleep apnea (HP:0002870)2.48804893
36Rhinitis (HP:0012384)2.47771520
37Recurrent sinusitis (HP:0011108)2.47462794
38Curly hair (HP:0002212)2.47151169
39Arterial thrombosis (HP:0004420)2.47131334
40Deep philtrum (HP:0002002)2.45836030
41Menstrual irregularities (HP:0000858)2.45126184
42Abnormality of the nasal mucosa (HP:0000433)2.44941267
43Hypochromic microcytic anemia (HP:0004840)2.43189732
44Abnormal respiratory motile cilium physiology (HP:0012261)2.43187805
45Prolonged bleeding time (HP:0003010)2.43178035
46Osteolytic defects of the hand bones (HP:0009699)2.37558011
47Osteolytic defects of the phalanges of the hand (HP:0009771)2.37558011
48Keratoconjunctivitis sicca (HP:0001097)2.35470677
49Meningitis (HP:0001287)2.34084374
50Abnormality of the nasal septum (HP:0000419)2.33415157
51Chronic bronchitis (HP:0004469)2.33234453
52Periodontitis (HP:0000704)2.31358284
53Long eyelashes (HP:0000527)2.31312540
54Recurrent gram-negative bacterial infections (HP:0005420)2.30328287
55Asymmetry of the thorax (HP:0001555)2.29415512
56Verrucae (HP:0200043)2.28571549
57Papilloma (HP:0012740)2.28571549
58Orchitis (HP:0100796)2.27712409
59J-shaped sella turcica (HP:0002680)2.26716287
60Micronodular cirrhosis (HP:0001413)2.26591802
61Abnormal platelet volume (HP:0011876)2.26361589
62Abnormal foot bone ossification (HP:0010675)2.25693855
63IgM deficiency (HP:0002850)2.25531468
64Bronchiectasis (HP:0002110)2.25147718
65Deformed sella turcica (HP:0002681)2.23272421
66Optic neuritis (HP:0100653)2.23099487
67Retrobulbar optic neuritis (HP:0100654)2.23099487
68IgA deficiency (HP:0002720)2.23074806
69Testicular neoplasm (HP:0010788)2.21419508
70Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.21049468
71Abnormal ciliary motility (HP:0012262)2.19218287
72Colitis (HP:0002583)2.19091289
73Osteomyelitis (HP:0002754)2.18937859
74Macroorchidism (HP:0000053)2.17898415
75Abnormality of B cell number (HP:0010975)2.17267908
76B lymphocytopenia (HP:0010976)2.17267908
77Mediastinal lymphadenopathy (HP:0100721)2.16643978
78Long clavicles (HP:0000890)2.15638580
79Thyroiditis (HP:0100646)2.15286506
80Gastrointestinal infarctions (HP:0005244)2.15157814
81Keratoconjunctivitis (HP:0001096)2.14701824
82Chronic obstructive pulmonary disease (HP:0006510)2.14342383
83Obstructive lung disease (HP:0006536)2.14342383
84Increased mean platelet volume (HP:0011877)2.13424293
85Hyperkalemia (HP:0002153)2.11208733
86Chronic sinusitis (HP:0011109)2.09629649
87Enlarged penis (HP:0000040)2.09298589
88Pustule (HP:0200039)2.08712016
89Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.06566604
90Dysmetric saccades (HP:0000641)2.06557061
91Papilledema (HP:0001085)2.05261356
92Abnormal hair whorl (HP:0010721)2.03349658
93Urethral obstruction (HP:0000796)2.03335124
94Truncal obesity (HP:0001956)2.01896766
95Bronchitis (HP:0012387)2.01724767
96Thrombocytosis (HP:0001894)2.00982586
97Spontaneous hematomas (HP:0007420)2.00305329
98Broad face (HP:0000283)1.99948462
99Elevated erythrocyte sedimentation rate (HP:0003565)1.99664517
100Narrow palate (HP:0000189)1.99034112
101Panhypogammaglobulinemia (HP:0003139)1.98389893
102Increased IgE level (HP:0003212)1.98207026
103Abnormality of the columella (HP:0009929)1.98122164
104Abnormal delayed hypersensitivity skin test (HP:0002963)1.97370256
105Recurrent cutaneous fungal infections (HP:0011370)1.96325329
106Chronic mucocutaneous candidiasis (HP:0002728)1.96325329
107Abnormal platelet function (HP:0011869)1.94098673
108Impaired platelet aggregation (HP:0003540)1.94098673
109Recurrent skin infections (HP:0001581)1.93005680
110Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.90917715
111Spondylolisthesis (HP:0003302)1.90382820
112Gingivitis (HP:0000230)1.89277714
113Broad palm (HP:0001169)1.88996124
114Cranial hyperostosis (HP:0004437)1.88919983
115Prostate neoplasm (HP:0100787)1.88359274
116Abnormality of the sella turcica (HP:0002679)1.88003043
117Subacute progressive viral hepatitis (HP:0006572)1.87840980
118Short 4th metacarpal (HP:0010044)1.87192309
119Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.87192309
120Genetic anticipation (HP:0003743)1.86405904
121Transitional cell carcinoma of the bladder (HP:0006740)1.85322651
122Chronic otitis media (HP:0000389)1.84727689
123Interstitial pulmonary disease (HP:0006530)1.84581769
124Lip pit (HP:0100267)1.84424630
125Petechiae (HP:0000967)1.83702187
126Abnormality of macrophages (HP:0004311)1.83558521
127Gingival bleeding (HP:0000225)1.83121140
128Cone-rod dystrophy (HP:0000548)1.82782321
129Recurrent otitis media (HP:0000403)1.82661473
130Autoimmune hemolytic anemia (HP:0001890)1.82155652
131Toxemia of pregnancy (HP:0100603)1.82153386
132Inflammation of the large intestine (HP:0002037)1.81490266
133Chest pain (HP:0100749)1.80346314
134Flat acetabular roof (HP:0003180)1.79488823
135Viral hepatitis (HP:0006562)1.79171097
136Abnormality of T cells (HP:0002843)1.79131989
137Dislocated radial head (HP:0003083)1.78779943
138Vasculitis (HP:0002633)1.77945890
139Abnormality of the radial head (HP:0003995)1.76828399
140Abnormality of the prostate (HP:0008775)1.75921312
141Bicuspid aortic valve (HP:0001647)1.74451622
142Epistaxis (HP:0000421)1.74267060
143Resting tremor (HP:0002322)1.70804198
144Subaortic stenosis (HP:0001682)1.69613722
145Abnormality of the left ventricular outflow tract (HP:0011103)1.69613722
146Bladder carcinoma (HP:0002862)1.69535999
147Bladder neoplasm (HP:0009725)1.69535999
148Hyporeflexia of lower limbs (HP:0002600)1.68525231
149Heterotopia (HP:0002282)1.68427934
150Coarse hair (HP:0002208)1.66594719
151Neonatal hypoglycemia (HP:0001998)1.64930611

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.20527434
2PRPF4B3.00586827
3TXK2.68235074
4STK102.61205057
5FRK2.33997777
6SCYL22.29861557
7NEK62.16750837
8FGFR32.15757575
9MAP3K22.15128058
10SGK32.14863770
11SGK22.14641186
12NEK92.10817444
13TRPM71.90595639
14MAP3K141.90011552
15TEC1.89261781
16EEF2K1.76934712
17ITK1.74040130
18CDK121.70392522
19TAOK31.68823355
20TGFBR21.65721300
21STK241.64508844
22IRAK41.64128743
23BRSK21.62246025
24JAK11.61485981
25JAK31.52494489
26MAP2K31.49171460
27ERBB31.47546344
28RPS6KB21.47413037
29STK31.46743958
30LATS11.45199072
31CAMK1D1.44287766
32NUAK11.43990124
33BTK1.41343562
34KSR21.40821181
35CDK61.39205530
36SMG11.39112412
37YES11.37941649
38MAPK151.36238166
39FES1.35614952
40CLK11.35558429
41ZAK1.35509715
42PIM11.30493214
43SIK31.29434111
44ZAP701.29056348
45CAMK1G1.27632746
46TYK21.27080950
47RIPK11.25979385
48MAP3K101.25764068
49IRAK31.24630386
50RET1.24487784
51STK41.22933095
52IKBKE1.20338080
53CHUK1.16747561
54SYK1.11744814
55PTK61.10284792
56TRIB31.07111547
57LRRK21.05798323
58MARK21.05636781
59CAMKK11.04642208
60CSK1.04345765
61DMPK1.01926800
62RPS6KA41.01316425
63RIPK40.97885209
64BLK0.97505309
65PDPK10.96203602
66PRKCH0.96153656
67MAP3K60.94894373
68MAP3K10.93351197
69CDK90.92471070
70HCK0.90925203
71MAP3K30.89358490
72NLK0.89357914
73KIT0.88974405
74PIK3CG0.87739196
75MST40.86066670
76EPHB10.86033072
77MTOR0.82926692
78GRK60.82569756
79IRAK20.82514065
80SGK2230.82506959
81SGK4940.82506959
82IRAK10.82374285
83MARK30.81382141
84STK380.81217123
85MELK0.80216923
86MAP2K20.78784399
87TAOK10.77710873
88ICK0.77477205
89JAK20.77061851
90CSF1R0.76523632
91IKBKB0.76466971
92RPS6KL10.76323146
93RPS6KC10.76323146
94RPS6KA60.75874706
95MAP3K130.75797932
96ERN10.75634593
97BMPR20.74146898
98PKN20.73704288
99TBK10.73201512
100HIPK20.72880662
101TTN0.70740324
102RPS6KA20.70329221
103BRD40.70081406
104SIK10.67886526
105TNK20.67146891
106FGFR20.66670801
107AKT30.65850209
108BRSK10.64040545
109PRKCQ0.63613676
110FGFR40.62379879
111RPS6KB10.59862324
112PDK10.58939762
113MAP3K50.57861199
114KSR10.57587984
115LCK0.57310007
116MAPK120.57137872
117MAP3K70.56622468
118EPHA30.56611393
119PDGFRB0.54298988
120CAMKK20.52572166
121WNK10.50615599
122PNCK0.50484906
123CDK40.50440797
124NEK20.49616729
125TYRO30.48737205
126PIK3CA0.48410206
127MAPK100.47512693
128MAPKAPK20.45376311
129CAMK40.44156477
130MAPK70.42961051
131SGK10.41771085
132CDC42BPA0.41727997
133MAPK30.38503787
134LYN0.38072946

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.21698875
2Primary immunodeficiency_Homo sapiens_hsa053402.03542223
3Osteoclast differentiation_Homo sapiens_hsa043801.93058801
4B cell receptor signaling pathway_Homo sapiens_hsa046621.92638817
5Intestinal immune network for IgA production_Homo sapiens_hsa046721.86309137
6NF-kappa B signaling pathway_Homo sapiens_hsa040641.77099859
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.76494407
8Renal cell carcinoma_Homo sapiens_hsa052111.71973407
9Hematopoietic cell lineage_Homo sapiens_hsa046401.70532357
10Toxoplasmosis_Homo sapiens_hsa051451.59695395
11Measles_Homo sapiens_hsa051621.59493150
12Chronic myeloid leukemia_Homo sapiens_hsa052201.59174332
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.51126549
14VEGF signaling pathway_Homo sapiens_hsa043701.49562943
15T cell receptor signaling pathway_Homo sapiens_hsa046601.48036159
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.47216611
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44365630
18Pancreatic cancer_Homo sapiens_hsa052121.42260993
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41957942
20ErbB signaling pathway_Homo sapiens_hsa040121.40045077
21Platelet activation_Homo sapiens_hsa046111.39940247
22Choline metabolism in cancer_Homo sapiens_hsa052311.39801031
23Hepatitis B_Homo sapiens_hsa051611.35981661
24Acute myeloid leukemia_Homo sapiens_hsa052211.35049886
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28744189
26Chemokine signaling pathway_Homo sapiens_hsa040621.26634448
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.25282304
28TNF signaling pathway_Homo sapiens_hsa046681.24943428
29Antigen processing and presentation_Homo sapiens_hsa046121.24067086
30Influenza A_Homo sapiens_hsa051641.23013213
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.21286224
32Long-term potentiation_Homo sapiens_hsa047201.20454342
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.18385180
34Malaria_Homo sapiens_hsa051441.17628133
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17527221
36Non-small cell lung cancer_Homo sapiens_hsa052231.16631409
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16380560
38FoxO signaling pathway_Homo sapiens_hsa040681.16319961
39Herpes simplex infection_Homo sapiens_hsa051681.15832696
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.15825682
41Tuberculosis_Homo sapiens_hsa051521.14497864
42Prolactin signaling pathway_Homo sapiens_hsa049171.13402849
43Endometrial cancer_Homo sapiens_hsa052131.12361028
44Insulin resistance_Homo sapiens_hsa049311.10304825
45Small cell lung cancer_Homo sapiens_hsa052221.08837991
46Apoptosis_Homo sapiens_hsa042101.07205895
47Adherens junction_Homo sapiens_hsa045201.06180741
48Prostate cancer_Homo sapiens_hsa052151.05165186
49Sphingolipid signaling pathway_Homo sapiens_hsa040711.02744976
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00303111
51Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99936807
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.99664061
53Pertussis_Homo sapiens_hsa051330.98290492
54MicroRNAs in cancer_Homo sapiens_hsa052060.97090626
55Focal adhesion_Homo sapiens_hsa045100.97067247
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96400841
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96160592
58Staphylococcus aureus infection_Homo sapiens_hsa051500.95481364
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94804258
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94215270
61Hepatitis C_Homo sapiens_hsa051600.93401681
62Proteoglycans in cancer_Homo sapiens_hsa052050.91829420
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91258818
64GnRH signaling pathway_Homo sapiens_hsa049120.91248148
65Colorectal cancer_Homo sapiens_hsa052100.89312193
66HTLV-I infection_Homo sapiens_hsa051660.89158121
67Viral carcinogenesis_Homo sapiens_hsa052030.88757117
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86171366
69Legionellosis_Homo sapiens_hsa051340.86079005
70Viral myocarditis_Homo sapiens_hsa054160.83550867
71mTOR signaling pathway_Homo sapiens_hsa041500.82872465
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82757548
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80906029
74Glioma_Homo sapiens_hsa052140.78990570
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78875918
76Circadian rhythm_Homo sapiens_hsa047100.78398155
77Type II diabetes mellitus_Homo sapiens_hsa049300.77934674
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76746710
79Lysine degradation_Homo sapiens_hsa003100.75304576
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73053942
81Inositol phosphate metabolism_Homo sapiens_hsa005620.72942464
82AMPK signaling pathway_Homo sapiens_hsa041520.72458881
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.71202256
84Dorso-ventral axis formation_Homo sapiens_hsa043200.70318519
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69212597
86Amoebiasis_Homo sapiens_hsa051460.68670402
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67815338
88Asthma_Homo sapiens_hsa053100.66851724
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.66648679
90Endocytosis_Homo sapiens_hsa041440.64401579
91Shigellosis_Homo sapiens_hsa051310.63838060
92ECM-receptor interaction_Homo sapiens_hsa045120.63707046
93Cell cycle_Homo sapiens_hsa041100.62896520
94HIF-1 signaling pathway_Homo sapiens_hsa040660.62751424
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61495350
96MAPK signaling pathway_Homo sapiens_hsa040100.61297490
97Thyroid cancer_Homo sapiens_hsa052160.60404691
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60206762
99Notch signaling pathway_Homo sapiens_hsa043300.59623783
100Bladder cancer_Homo sapiens_hsa052190.57326683
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57137642
102Olfactory transduction_Homo sapiens_hsa047400.57115949
103Salmonella infection_Homo sapiens_hsa051320.56387260
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56176911
105Insulin signaling pathway_Homo sapiens_hsa049100.55420932
106Melanoma_Homo sapiens_hsa052180.54926428
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54651191
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54001697
109ABC transporters_Homo sapiens_hsa020100.53439707
110Long-term depression_Homo sapiens_hsa047300.53181799
111Pathways in cancer_Homo sapiens_hsa052000.53122070
112Estrogen signaling pathway_Homo sapiens_hsa049150.52853806
113Oxytocin signaling pathway_Homo sapiens_hsa049210.52793541
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51940114
115Rap1 signaling pathway_Homo sapiens_hsa040150.51410697
116Allograft rejection_Homo sapiens_hsa053300.51251171
117TGF-beta signaling pathway_Homo sapiens_hsa043500.51123020
118Cholinergic synapse_Homo sapiens_hsa047250.49961609
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49857841
120Graft-versus-host disease_Homo sapiens_hsa053320.49495660
121African trypanosomiasis_Homo sapiens_hsa051430.48398074
122Thyroid hormone synthesis_Homo sapiens_hsa049180.48077271
123cAMP signaling pathway_Homo sapiens_hsa040240.46789791
124Ras signaling pathway_Homo sapiens_hsa040140.45070786

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