HIPK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)5.78592466
2axon ensheathment in central nervous system (GO:0032291)5.78592466
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.29584487
4cellular potassium ion homeostasis (GO:0030007)4.66440073
5sodium ion export (GO:0071436)4.36943458
6membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.34445274
7synaptic vesicle maturation (GO:0016188)4.18325326
8glutamate secretion (GO:0014047)4.09549977
9axon ensheathment (GO:0008366)3.96747047
10ensheathment of neurons (GO:0007272)3.96747047
11regulation of short-term neuronal synaptic plasticity (GO:0048172)3.94941090
12myelination (GO:0042552)3.91631148
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.85903101
14cerebellar granule cell differentiation (GO:0021707)3.82720630
15creatine metabolic process (GO:0006600)3.82204551
16regulation of synaptic vesicle exocytosis (GO:2000300)3.74455253
17cell communication by electrical coupling (GO:0010644)3.71356485
18synaptic vesicle exocytosis (GO:0016079)3.66541154
19locomotory exploration behavior (GO:0035641)3.63430399
20potassium ion homeostasis (GO:0055075)3.62278245
21postsynaptic membrane organization (GO:0001941)3.51447762
22import into cell (GO:0098657)3.50102654
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.44163606
24response to methylmercury (GO:0051597)3.36680549
25regulation of neuronal synaptic plasticity (GO:0048168)3.36598394
26neuronal ion channel clustering (GO:0045161)3.33460135
27vocalization behavior (GO:0071625)3.32045174
28cellular response to epinephrine stimulus (GO:0071872)3.29381511
29cellular sodium ion homeostasis (GO:0006883)3.28296242
30cytoskeletal anchoring at plasma membrane (GO:0007016)3.27736827
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.27118868
32response to lipoprotein particle (GO:0055094)3.27011106
33regulation of synaptic vesicle transport (GO:1902803)3.23483093
34L-amino acid import (GO:0043092)3.21273882
35photoreceptor cell differentiation (GO:0046530)3.19944823
36eye photoreceptor cell differentiation (GO:0001754)3.19944823
37regulation of sequestering of triglyceride (GO:0010889)3.15822450
38neurotransmitter-gated ion channel clustering (GO:0072578)3.15465575
39cytoplasmic mRNA processing body assembly (GO:0033962)3.14959592
40myelin maintenance (GO:0043217)3.14932257
41regulation of ARF protein signal transduction (GO:0032012)3.14910687
42presynaptic membrane organization (GO:0097090)3.13631595
43neurotransmitter secretion (GO:0007269)3.13310327
44peripheral nervous system axon ensheathment (GO:0032292)3.07258609
45myelination in peripheral nervous system (GO:0022011)3.07258609
46negative regulation of protein localization to cell surface (GO:2000009)3.05164755
47presynaptic membrane assembly (GO:0097105)3.03160931
48positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.02349059
49regulation of long-term neuronal synaptic plasticity (GO:0048169)3.01195254
50peptidyl-tyrosine autophosphorylation (GO:0038083)2.99518449
51positive regulation of synapse maturation (GO:0090129)2.97132040
52cell communication involved in cardiac conduction (GO:0086065)2.95917454
53neuron cell-cell adhesion (GO:0007158)2.93780747
54response to epinephrine (GO:0071871)2.92177449
55neuromuscular process controlling balance (GO:0050885)2.90426789
56cardiac myofibril assembly (GO:0055003)2.89873292
57myofibril assembly (GO:0030239)2.86191416
58positive regulation of dendritic spine development (GO:0060999)2.85883036
59regulation of glutamate receptor signaling pathway (GO:1900449)2.85473772
60synaptic transmission, glutamatergic (GO:0035249)2.83849684
61fatty acid elongation (GO:0030497)2.82994467
62nerve growth factor signaling pathway (GO:0038180)2.82018460
63exploration behavior (GO:0035640)2.81949893
64sarcomere organization (GO:0045214)2.80712944
65axonal fasciculation (GO:0007413)2.80408150
66regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.79081540
67asymmetric protein localization (GO:0008105)2.73952296
68negative regulation of neurotransmitter secretion (GO:0046929)2.73225611
69regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.72024175
70activation of protein kinase A activity (GO:0034199)2.71602888
71neuronal action potential propagation (GO:0019227)2.71281374
72neuron recognition (GO:0008038)2.70051125
73regulation of cardioblast differentiation (GO:0051890)2.67171550
74membrane tubulation (GO:0097320)2.66584118
75glutamate receptor signaling pathway (GO:0007215)2.66136707
76adult heart development (GO:0007512)2.65771999
77auditory behavior (GO:0031223)2.65676857
78protein localization to synapse (GO:0035418)2.65449481
79astrocyte differentiation (GO:0048708)2.65326103
80regulation of synaptic plasticity (GO:0048167)2.65171321
81regulation of synapse structural plasticity (GO:0051823)2.64206535
82positive regulation of oligodendrocyte differentiation (GO:0048714)2.62660020
83positive regulation of membrane potential (GO:0045838)2.59908777
84protoporphyrinogen IX metabolic process (GO:0046501)2.59594185
85growth hormone receptor signaling pathway (GO:0060396)2.59218263
86regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.58001364
87membrane assembly (GO:0071709)2.57333030
88regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.57135095
89synaptic vesicle endocytosis (GO:0048488)2.56091037
90negative regulation of dendrite morphogenesis (GO:0050774)2.54102332
91layer formation in cerebral cortex (GO:0021819)2.51833149
92neuron-neuron synaptic transmission (GO:0007270)2.51627429
93cerebellar Purkinje cell differentiation (GO:0021702)2.51064072
94low-density lipoprotein particle clearance (GO:0034383)2.50233357
95atrioventricular valve morphogenesis (GO:0003181)2.48984717
96cortical actin cytoskeleton organization (GO:0030866)2.48464987
97neurotransmitter transport (GO:0006836)2.48463966
98gamma-aminobutyric acid transport (GO:0015812)2.48109849
99regulation of excitatory postsynaptic membrane potential (GO:0060079)2.46781435
100regulation of synapse maturation (GO:0090128)2.46187308
101glycine transport (GO:0015816)2.46114917
102membrane depolarization during action potential (GO:0086010)2.45962778
103* embryonic retina morphogenesis in camera-type eye (GO:0060059)2.45762113
104apical protein localization (GO:0045176)2.45760255
105positive regulation of fatty acid beta-oxidation (GO:0032000)2.45241756
106negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.44778789
107positive regulation of dendrite development (GO:1900006)2.44657270
108positive regulation of action potential (GO:0045760)2.44466993
109positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.43527073
110long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.43272646
111amino acid import (GO:0043090)2.43163506
112regulation of neurotransmitter secretion (GO:0046928)2.42602208
113regulation of postsynaptic membrane potential (GO:0060078)2.41943921
114detection of calcium ion (GO:0005513)2.41923605
115positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.41435744
116regulation of dendritic spine morphogenesis (GO:0061001)2.41146699
117regulation of p38MAPK cascade (GO:1900744)2.41114993
118positive regulation of neurological system process (GO:0031646)2.40637570
119cellular response to catecholamine stimulus (GO:0071870)2.40468479
120cellular response to monoamine stimulus (GO:0071868)2.40468479
121long-chain fatty acid biosynthetic process (GO:0042759)2.39624036
122regulation of dendritic spine development (GO:0060998)2.39375687
123oligodendrocyte differentiation (GO:0048709)2.38110259
124cell differentiation in hindbrain (GO:0021533)2.37780888
125histone H3-K4 trimethylation (GO:0080182)2.37780593
126fatty-acyl-CoA biosynthetic process (GO:0046949)2.37709169
127long-term memory (GO:0007616)2.37339797
128neurotransmitter uptake (GO:0001504)2.37068325
129gamma-aminobutyric acid signaling pathway (GO:0007214)2.36220191
130negative regulation of potassium ion transmembrane transport (GO:1901380)2.35770646
131regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.35037193
132G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.34075706
133acidic amino acid transport (GO:0015800)2.34055452
134relaxation of cardiac muscle (GO:0055119)2.33921829
135retrograde transport, vesicle recycling within Golgi (GO:0000301)2.29710220
136regulation of actin filament-based movement (GO:1903115)2.29544031
137regulation of lipoprotein metabolic process (GO:0050746)2.29395629
138glomerular filtration (GO:0003094)2.28313629
139carnitine shuttle (GO:0006853)2.28285594
140astrocyte development (GO:0014002)2.24879126
141negative regulation of neurotransmitter transport (GO:0051589)2.23742829
142cerebral cortex radially oriented cell migration (GO:0021799)2.23102513
143negative regulation of cytosolic calcium ion concentration (GO:0051481)2.22489246
144protoporphyrinogen IX biosynthetic process (GO:0006782)2.21723687
145triglyceride biosynthetic process (GO:0019432)2.20625012
146fatty acid transmembrane transport (GO:1902001)2.19655363
147positive regulation of fatty acid oxidation (GO:0046321)2.19497794
148positive regulation of p38MAPK cascade (GO:1900745)2.19479860
149dendritic spine morphogenesis (GO:0060997)2.18212373
150cortical cytoskeleton organization (GO:0030865)2.16718256
151response to catecholamine (GO:0071869)2.16564237
152response to monoamine (GO:0071867)2.16564237
153cellular response to growth hormone stimulus (GO:0071378)2.16207340
154neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.15482642
155neurotransmitter catabolic process (GO:0042135)2.14976586
156long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.13831322
157cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.13734073
158regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.13694443
159positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.13694443
160acylglycerol biosynthetic process (GO:0046463)2.13288676
161neutral lipid biosynthetic process (GO:0046460)2.13288676
162insulin-like growth factor receptor signaling pathway (GO:0048009)2.13271205
163atrial septum morphogenesis (GO:0060413)2.12458340
164positive regulation of cellular response to insulin stimulus (GO:1900078)2.12354004
165thioester biosynthetic process (GO:0035384)2.11999847
166acyl-CoA biosynthetic process (GO:0071616)2.11999847
167regulation of somitogenesis (GO:0014807)2.11312378
168protein targeting to Golgi (GO:0000042)2.10604710
169dendrite morphogenesis (GO:0048813)2.10302601
170regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.09927585
171camera-type eye morphogenesis (GO:0048593)2.09762694
172potassium ion import (GO:0010107)2.09196977
173actomyosin structure organization (GO:0031032)2.08860084
174plasma membrane repair (GO:0001778)2.08107688
175fatty-acyl-CoA metabolic process (GO:0035337)2.06540274
176nucleus localization (GO:0051647)2.06312653
177semaphorin-plexin signaling pathway (GO:0071526)2.04865128
178cardiac muscle tissue morphogenesis (GO:0055008)2.04491293

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.28591395
2* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.18314527
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.16703792
4EZH2_22144423_ChIP-Seq_EOC_Human2.16472310
5DROSHA_22980978_ChIP-Seq_HELA_Human2.10470598
6EP300_21415370_ChIP-Seq_HL-1_Mouse2.06021428
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01355380
8REST_21632747_ChIP-Seq_MESCs_Mouse1.84618219
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83233709
10GBX2_23144817_ChIP-Seq_PC3_Human1.75434404
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.74486642
12GATA1_19941826_ChIP-Seq_K562_Human1.69099903
13ESR1_20079471_ChIP-ChIP_T-47D_Human1.68335485
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67555747
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.67118423
16* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64218906
17ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.64009900
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63359924
19EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62326488
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62326488
21* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57341428
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.56287226
23* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54979396
24* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54594886
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54449750
26* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.53131854
27AR_21572438_ChIP-Seq_LNCaP_Human1.52786446
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49029122
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46596010
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.41205655
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.40855356
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39898947
33* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38295029
34RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.37830478
35* FOXA2_19822575_ChIP-Seq_HepG2_Human1.36268248
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.34943399
37* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34443008
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34205943
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.33969396
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33330512
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31790369
42* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31107119
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.31102341
44TBX20_22080862_ChIP-Seq_HEART_Mouse1.30710862
45TBX20_22328084_ChIP-Seq_HEART_Mouse1.30710862
46CTNNB1_20460455_ChIP-Seq_HCT116_Human1.29882422
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.29311911
48VDR_24787735_ChIP-Seq_THP-1_Human1.27983268
49KDM2B_26808549_Chip-Seq_K562_Human1.27857906
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.27527911
51RING1B_27294783_Chip-Seq_NPCs_Mouse1.26270909
52AHR_22903824_ChIP-Seq_MCF-7_Human1.25772635
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25745554
54TP53_16413492_ChIP-PET_HCT116_Human1.24539997
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24521044
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23752931
57* ISL1_27105846_Chip-Seq_CPCs_Mouse1.23195386
58ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23020400
59TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23008481
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21567184
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.21264521
62* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.21257187
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20386548
64* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20276864
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20053725
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.19174024
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18571510
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16603959
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.14351306
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.13918002
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13007279
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.12736991
73* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12694378
74* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12633756
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.12301819
76* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11771857
77* STAT3_23295773_ChIP-Seq_U87_Human1.11483408
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11318038
79* ESR2_21235772_ChIP-Seq_MCF-7_Human1.10761199
80BP1_19119308_ChIP-ChIP_Hs578T_Human1.10697167
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.10558243
82GATA2_19941826_ChIP-Seq_K562_Human1.09775306
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08995533
84* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07984652
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07391696
86GATA1_19941827_ChIP-Seq_MEL_Mouse1.05515658
87ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05343347
88NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04342487
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03608559
90RARB_27405468_Chip-Seq_BRAIN_Mouse1.03141631
91AR_19668381_ChIP-Seq_PC3_Human1.02908617
92RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02718803
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02673993
94* SOX2_21211035_ChIP-Seq_LN229_Gbm1.01225194
95* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01160960
96SMAD4_21799915_ChIP-Seq_A2780_Human1.00208897
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99930280
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97424496
99KDM2B_26808549_Chip-Seq_DND41_Human0.97399312
100* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97354660
101SMAD_19615063_ChIP-ChIP_OVARY_Human0.96498272
102ER_23166858_ChIP-Seq_MCF-7_Human0.96441101
103* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95367711
104* TCF4_23295773_ChIP-Seq_U87_Human0.95035289
105EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94976055
106* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94873749
107DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94773854
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.94698160
109KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94300558
110PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94066849
111KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.93753982
112TBL1_22424771_ChIP-Seq_293T_Human0.93661799
113SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93348274
114EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93257580
115* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93110040
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92709486
117SMAD3_21741376_ChIP-Seq_HESCs_Human0.92581006
118YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91766888
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91495610
120* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91419399
121STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91090068
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90556550
123ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90306977
124RNF2_27304074_Chip-Seq_NSC_Mouse0.88031286

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.42712739
2MP0004185_abnormal_adipocyte_glucose3.34930887
3MP0000920_abnormal_myelination3.33072090
4MP0005423_abnormal_somatic_nervous3.29355769
5MP0003950_abnormal_plasma_membrane3.27685222
6MP0005670_abnormal_white_adipose3.22938754
7MP0003635_abnormal_synaptic_transmissio3.14892873
8MP0003880_abnormal_central_pattern3.02569705
9MP0005666_abnormal_adipose_tissue3.00378660
10MP0004130_abnormal_muscle_cell2.85384760
11MP0003690_abnormal_glial_cell2.80682222
12MP0002063_abnormal_learning/memory/cond2.59289320
13MP0004147_increased_porphyrin_level2.59128782
14MP0003646_muscle_fatigue2.46637255
15MP0005375_adipose_tissue_phenotype2.40118014
16MP0002734_abnormal_mechanical_nocicepti2.31599098
17MP0009745_abnormal_behavioral_response2.31518301
18MP0003656_abnormal_erythrocyte_physiolo2.23066901
19MP0000751_myopathy2.21927703
20MP0008775_abnormal_heart_ventricle2.19196147
21MP0000569_abnormal_digit_pigmentation2.14840449
22MP0004084_abnormal_cardiac_muscle2.12918970
23MP0004215_abnormal_myocardial_fiber2.10899286
24MP0002572_abnormal_emotion/affect_behav2.07278559
25MP0003879_abnormal_hair_cell2.03419913
26MP0002735_abnormal_chemical_nociception2.00841620
27MP0000749_muscle_degeneration1.96560753
28MP0004036_abnormal_muscle_relaxation1.90255977
29MP0004087_abnormal_muscle_fiber1.88046546
30MP0003137_abnormal_impulse_conducting1.86844535
31MP0002972_abnormal_cardiac_muscle1.84351736
32MP0000003_abnormal_adipose_tissue1.82508025
33MP0009780_abnormal_chondrocyte_physiolo1.72918478
34MP0002971_abnormal_brown_adipose1.71992689
35MP0001502_abnormal_circadian_rhythm1.70566204
36MP0001501_abnormal_sleep_pattern1.67775142
37MP0005409_darkened_coat_color1.67248936
38MP0005620_abnormal_muscle_contractility1.65434981
39MP0005330_cardiomyopathy1.62825434
40MP0004270_analgesia1.60269471
41MP0006138_congestive_heart_failure1.56634724
42MP0003634_abnormal_glial_cell1.56031965
43MP0010630_abnormal_cardiac_muscle1.54802629
44MP0001970_abnormal_pain_threshold1.54016300
45MP0001299_abnormal_eye_distance/1.51521250
46MP0003122_maternal_imprinting1.48681595
47MP0001984_abnormal_olfaction1.48577436
48MP0000955_abnormal_spinal_cord1.47887273
49MP0005167_abnormal_blood-brain_barrier1.46721600
50MP0001486_abnormal_startle_reflex1.45465315
51* MP0002067_abnormal_sensory_capabilities1.45255947
52MP0001968_abnormal_touch/_nociception1.44330310
53MP0005385_cardiovascular_system_phenoty1.43813550
54MP0001544_abnormal_cardiovascular_syste1.43813550
55MP0002733_abnormal_thermal_nociception1.43533662
56MP0002557_abnormal_social/conspecific_i1.42759761
57MP0001440_abnormal_grooming_behavior1.38595399
58MP0005646_abnormal_pituitary_gland1.38138603
59MP0004811_abnormal_neuron_physiology1.36068796
60MP0004085_abnormal_heartbeat1.35415865
61MP0000383_abnormal_hair_follicle1.31027337
62MP0000778_abnormal_nervous_system1.28997126
63MP0004742_abnormal_vestibular_system1.28638061
64* MP0002066_abnormal_motor_capabilities/c1.25090946
65MP0004145_abnormal_muscle_electrophysio1.24629748
66MP0003283_abnormal_digestive_organ1.24128537
67MP0000747_muscle_weakness1.22531134
68MP0002909_abnormal_adrenal_gland1.20848815
69MP0000733_abnormal_muscle_development1.19788920
70MP0002106_abnormal_muscle_physiology1.17983630
71MP0002090_abnormal_vision1.17879218
72MP0008438_abnormal_cutaneous_collagen1.17735595
73MP0004885_abnormal_endolymph1.16243025
74MP0000759_abnormal_skeletal_muscle1.15977347
75MP0003045_fibrosis1.15791487
76MP0001529_abnormal_vocalization1.15743773
77MP0002152_abnormal_brain_morphology1.13625502
78MP0002184_abnormal_innervation1.12378570
79MP0008961_abnormal_basal_metabolism1.11905452
80MP0005451_abnormal_body_composition1.10692444
81MP0003828_pulmonary_edema1.10338571
82MP0010678_abnormal_skin_adnexa1.09845450
83MP0000462_abnormal_digestive_system1.08621725
84MP0001177_atelectasis1.07539102
85MP0003329_amyloid_beta_deposits1.06847786
86MP0006276_abnormal_autonomic_nervous1.06371450
87MP0003632_abnormal_nervous_system1.04778728
88MP0005369_muscle_phenotype1.04180051
89MP0009840_abnormal_foam_cell1.04029192
90MP0001661_extended_life_span1.03126960
91MP0005623_abnormal_meninges_morphology1.03072989
92MP0005334_abnormal_fat_pad1.02110256
93MP0008569_lethality_at_weaning1.01057726
94MP0002229_neurodegeneration1.00439894
95MP0004510_myositis0.99854124
96MP0005551_abnormal_eye_electrophysiolog0.98845919
97MP0004233_abnormal_muscle_weight0.98109715
98MP0002118_abnormal_lipid_homeostasis0.97597014
99MP0005083_abnormal_biliary_tract0.95146595
100MP0005386_behavior/neurological_phenoty0.94668861
101MP0004924_abnormal_behavior0.94668861
102MP0003221_abnormal_cardiomyocyte_apopto0.93289680
103MP0004272_abnormal_basement_membrane0.93262694
104MP0004043_abnormal_pH_regulation0.92987833
105MP0000566_synostosis0.92104824
106MP0009115_abnormal_fat_cell0.89837599
107MP0004484_altered_response_of0.89692366
108MP0002089_abnormal_postnatal_growth/wei0.89690147
109MP0010368_abnormal_lymphatic_system0.88821380
110MP0005171_absent_coat_pigmentation0.87926390
111MP0003300_gastrointestinal_ulcer0.86770758
112MP0004859_abnormal_synaptic_plasticity0.86753601
113MP0000534_abnormal_ureter_morphology0.86701691
114MP0001963_abnormal_hearing_physiology0.85613647
115MP0002736_abnormal_nociception_after0.85379822
116MP0005448_abnormal_energy_balance0.83013922
117MP0005248_abnormal_Harderian_gland0.82472265
118MP0002064_seizures0.81914383
119MP0003091_abnormal_cell_migration0.80468478
120MP0002272_abnormal_nervous_system0.80154776
121MP0005535_abnormal_body_temperature0.78515117
122MP0005645_abnormal_hypothalamus_physiol0.78278054
123MP0003937_abnormal_limbs/digits/tail_de0.78212741
124MP0001485_abnormal_pinna_reflex0.78179892
125MP0002108_abnormal_muscle_morphology0.77760076
126MP0003705_abnormal_hypodermis_morpholog0.77444663
127MP0003123_paternal_imprinting0.76712048
128MP0001958_emphysema0.76666594
129MP0002638_abnormal_pupillary_reflex0.76035261
130MP0003631_nervous_system_phenotype0.75789689
131MP0001905_abnormal_dopamine_level0.75236365
132MP0004858_abnormal_nervous_system0.74487491
133MP0000750_abnormal_muscle_regeneration0.73315102
134MP0003172_abnormal_lysosome_physiology0.73307750
135MP0009384_cardiac_valve_regurgitation0.73300720
136MP0002269_muscular_atrophy0.73074560
137MP0005195_abnormal_posterior_eye0.72763217
138MP0000266_abnormal_heart_morphology0.72184386
139MP0002882_abnormal_neuron_morphology0.71800345
140MP0008874_decreased_physiological_sensi0.71237859
141MP0000579_abnormal_nail_morphology0.70368047
142MP0009046_muscle_twitch0.69899368
143MP0002822_catalepsy0.69203466
144MP0003633_abnormal_nervous_system0.68257338
145* MP0003861_abnormal_nervous_system0.66218878
146MP0002069_abnormal_eating/drinking_beha0.64760732
147MP0002249_abnormal_larynx_morphology0.64425430
148MP0003868_abnormal_feces_composition0.64293726
149MP0001348_abnormal_lacrimal_gland0.63914371
150MP0004142_abnormal_muscle_tone0.63566110
151MP0000026_abnormal_inner_ear0.62688024
152MP0001943_abnormal_respiration0.62686734
153MP0002082_postnatal_lethality0.62588695
154MP0010770_preweaning_lethality0.62588695
155MP0000631_abnormal_neuroendocrine_gland0.62452334

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.41445759
2Obstructive sleep apnea (HP:0002870)4.18171295
3Focal motor seizures (HP:0011153)4.17793426
4Hyporeflexia of lower limbs (HP:0002600)4.13247340
5Muscle fiber splitting (HP:0003555)4.09864907
6Neurofibrillary tangles (HP:0002185)3.92152853
7Sudden death (HP:0001699)3.81435527
8Focal seizures (HP:0007359)3.72076961
9Difficulty running (HP:0009046)3.68461534
10Febrile seizures (HP:0002373)3.59728525
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.50457676
12Degeneration of the lateral corticospinal tracts (HP:0002314)3.50457676
13Increased circulating renin level (HP:0000848)3.31494840
14Abnormality of binocular vision (HP:0011514)3.30026846
15Diplopia (HP:0000651)3.30026846
16Prolonged QT interval (HP:0001657)3.24606860
17Atrial fibrillation (HP:0005110)3.21403176
18Ventricular tachycardia (HP:0004756)3.18102157
19Muscle hypertrophy of the lower extremities (HP:0008968)3.16348494
20Calf muscle hypertrophy (HP:0008981)3.11411650
21Cerebral inclusion bodies (HP:0100314)3.11163835
22Atonic seizures (HP:0010819)3.10695124
23Epileptic encephalopathy (HP:0200134)3.02517176
24Poikilocytosis (HP:0004447)2.93980198
25Onion bulb formation (HP:0003383)2.92352937
26Macroorchidism (HP:0000053)2.90229965
27Ankle clonus (HP:0011448)2.88559728
28Primary atrial arrhythmia (HP:0001692)2.87527179
29Subaortic stenosis (HP:0001682)2.81148147
30Abnormality of the left ventricular outflow tract (HP:0011103)2.81148147
31Progressive cerebellar ataxia (HP:0002073)2.77117658
32Slow saccadic eye movements (HP:0000514)2.73355836
33Supranuclear gaze palsy (HP:0000605)2.71364954
34Lipoatrophy (HP:0100578)2.62395794
35Bronchomalacia (HP:0002780)2.61202289
36Supraventricular tachycardia (HP:0004755)2.60229576
37Abnormality of the calf musculature (HP:0001430)2.59239107
38Supraventricular arrhythmia (HP:0005115)2.55632474
39Intention tremor (HP:0002080)2.51023434
40Premature skin wrinkling (HP:0100678)2.49711451
41Exercise-induced myalgia (HP:0003738)2.48966889
42Truncal ataxia (HP:0002078)2.47464620
43Hypoplastic ischia (HP:0003175)2.47450956
44Abnormality of the corticospinal tract (HP:0002492)2.46471207
45Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.43928643
46Sensory axonal neuropathy (HP:0003390)2.41881158
47Axonal loss (HP:0003447)2.39463385
48Acanthocytosis (HP:0001927)2.39031750
49Sleep apnea (HP:0010535)2.38185912
50Dysmetria (HP:0001310)2.35020166
51Abnormal eating behavior (HP:0100738)2.32310199
52Diaphragmatic weakness (HP:0009113)2.32268242
53Papilledema (HP:0001085)2.30757726
54Scanning speech (HP:0002168)2.29810613
55Generalized tonic-clonic seizures (HP:0002069)2.28270456
56Termporal pattern (HP:0011008)2.27912266
57Insidious onset (HP:0003587)2.27912266
58Abnormality of the fingertips (HP:0001211)2.26745261
59Dysmetric saccades (HP:0000641)2.24484215
60Action tremor (HP:0002345)2.23557428
61Hemiplegia (HP:0002301)2.23542854
62Clumsiness (HP:0002312)2.23409838
63Absence seizures (HP:0002121)2.22120179
64Central scotoma (HP:0000603)2.21912886
65Abnormal auditory evoked potentials (HP:0006958)2.20124788
66Epileptiform EEG discharges (HP:0011182)2.19263022
67Syncope (HP:0001279)2.18412261
68Spastic gait (HP:0002064)2.17869718
69Hemiparesis (HP:0001269)2.16207899
70EMG: myopathic abnormalities (HP:0003458)2.15714801
71Bundle branch block (HP:0011710)2.13924976
72Scapular winging (HP:0003691)2.13106315
73Dilated cardiomyopathy (HP:0001644)2.12431799
74Abnormality of the ischium (HP:0003174)2.11530928
75Metabolic alkalosis (HP:0200114)2.09952993
76Hyperacusis (HP:0010780)2.07275535
77Right ventricular cardiomyopathy (HP:0011663)2.05889732
78Narrow palate (HP:0000189)2.02770598
79Overgrowth (HP:0001548)2.02646908
80Large for gestational age (HP:0001520)2.02422407
81Hypoplasia of the iris (HP:0007676)2.02271459
82Dialeptic seizures (HP:0011146)2.00760660
83Disproportionate tall stature (HP:0001519)2.00550139
84Shallow orbits (HP:0000586)1.99891192
85Hyperventilation (HP:0002883)1.96540764
86EEG with generalized epileptiform discharges (HP:0011198)1.96433022
87Depressed nasal tip (HP:0000437)1.96427187
88Gowers sign (HP:0003391)1.96269518
89Peripheral hypomyelination (HP:0007182)1.95771549
90Parakeratosis (HP:0001036)1.95545990
91Alacrima (HP:0000522)1.92923382
92Urethral obstruction (HP:0000796)1.92186783
93Dysdiadochokinesis (HP:0002075)1.92121154
94Lower limb muscle weakness (HP:0007340)1.90485548
95Genetic anticipation (HP:0003743)1.90422621
96Tracheomalacia (HP:0002779)1.87245585
97Pheochromocytoma (HP:0002666)1.85245766
98Broad metatarsal (HP:0001783)1.84790290
99Infantile muscular hypotonia (HP:0008947)1.84204248
100Torticollis (HP:0000473)1.84065233
101Urinary urgency (HP:0000012)1.80813795
102Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.80400416
103Vertebral arch anomaly (HP:0008438)1.80261304
104Drooling (HP:0002307)1.79552384
105Decreased lacrimation (HP:0000633)1.79308237
106Arterial tortuosity (HP:0005116)1.77941275
107Stereotypic behavior (HP:0000733)1.77301615
108Urinary bladder sphincter dysfunction (HP:0002839)1.77036897
109Turricephaly (HP:0000262)1.76199504
110Widely spaced teeth (HP:0000687)1.76008100
111Depression (HP:0000716)1.75178816
112Hypsarrhythmia (HP:0002521)1.74681608
113Insulin-resistant diabetes mellitus (HP:0000831)1.74053069
114Abnormality of the foot musculature (HP:0001436)1.73661809
115Abnormal EKG (HP:0003115)1.73185999
116Anxiety (HP:0000739)1.72227985
117Foot dorsiflexor weakness (HP:0009027)1.71970851
118Abnormal atrioventricular conduction (HP:0005150)1.69938359
119Hypokalemic alkalosis (HP:0001949)1.68872811
120Bowel incontinence (HP:0002607)1.68864025
121Heart block (HP:0012722)1.68789779
122Long eyelashes (HP:0000527)1.68667283
123Cholelithiasis (HP:0001081)1.68417812
124Annular pancreas (HP:0001734)1.68405621
125Blue irides (HP:0000635)1.67108566
126Abnormal gallbladder morphology (HP:0012437)1.66452734
127Midline defect of the nose (HP:0004122)1.66151620
128Decreased motor nerve conduction velocity (HP:0003431)1.65792690
129Postural instability (HP:0002172)1.65638692
130Lower limb amyotrophy (HP:0007210)1.65621926
131Pulmonary artery stenosis (HP:0004415)1.65429063
132Limb dystonia (HP:0002451)1.65393507
133Anteriorly placed anus (HP:0001545)1.64693006
134Laryngomalacia (HP:0001601)1.64454417
135Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.64137462
136Aplasia involving bones of the extremities (HP:0009825)1.64065762
137Aplasia involving bones of the upper limbs (HP:0009823)1.64065762
138Aplasia of the phalanges of the hand (HP:0009802)1.64065762
139Overriding aorta (HP:0002623)1.63368837
140Exercise-induced muscle cramps (HP:0003710)1.63325343
141Poor eye contact (HP:0000817)1.62097016
142Insomnia (HP:0100785)1.61941586
143Excessive salivation (HP:0003781)1.60824333
144Thickened helices (HP:0000391)1.60659051
145Myoglobinuria (HP:0002913)1.60041787
146Atrioventricular block (HP:0001678)1.59641772
147Coronal craniosynostosis (HP:0004440)1.59232794
148Rapidly progressive (HP:0003678)1.58784506
149Renovascular hypertension (HP:0100817)1.58600949
150Partial agenesis of the corpus callosum (HP:0001338)1.58337492
151Pigmentary retinal degeneration (HP:0001146)1.57817640
152Megalencephaly (HP:0001355)1.57783069
153Abnormal large intestine physiology (HP:0012700)1.57403763
154Hammertoe (HP:0001765)1.56098890
155Broad-based gait (HP:0002136)1.55402321
156Mask-like facies (HP:0000298)1.55018600
157Proximal amyotrophy (HP:0007126)1.54867301

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1G3.78650820
2CAMK1D3.48112394
3NTRK33.22475412
4EPHB13.19235545
5STK393.17854179
6DMPK2.65710576
7PKN12.29959362
8CASK2.29042613
9EPHA42.27990585
10ICK2.09669687
11WNK12.06309670
12MAP3K91.90776396
13LATS11.84754909
14FGFR21.84128211
15PIK3CA1.75874499
16AKT31.73533920
17DAPK21.72573647
18WNK41.69846977
19PHKG21.68774825
20PHKG11.68774825
21SIK11.63937168
22TRIB31.61632223
23OXSR11.61611495
24LATS21.52649964
25MET1.52320068
26OBSCN1.52047918
27LMTK21.48478866
28CDK121.45517053
29RIPK11.45318037
30CAMKK11.43585813
31INSRR1.41447729
32TTN1.37290468
33SGK2231.36479734
34SGK4941.36479734
35MINK11.32017372
36BCR1.29806224
37MARK21.26674177
38PAK61.23315704
39PRKAA21.20519047
40ROCK21.18301503
41NTRK21.17187506
42TAOK31.15660186
43PRKD11.13154750
44CAMK11.12644141
45NTRK11.07375201
46PDGFRB1.06451948
47UHMK11.03073352
48IRAK21.02504795
49STK41.02335840
50STK381.02035800
51PAK31.01861223
52KSR20.98900106
53BRD40.93049978
54ERBB20.92451088
55PBK0.92409117
56MAP3K100.92235639
57PRKCH0.91580592
58SGK30.90522939
59CAMK2D0.88704503
60EPHB20.88559265
61DDR20.88351417
62ROCK10.87662497
63MTOR0.87642411
64TYRO30.85616696
65BMX0.84771975
66PRKAA10.83910618
67CLK10.83440207
68PRKD30.82413779
69PDPK10.80646748
70FGFR30.79671017
71CSNK1A1L0.78177087
72PTK20.78131202
73CDK90.78106566
74PRKCG0.77155924
75SGK10.75833768
76PRKCQ0.75780878
77STK110.75655370
78KSR10.75531801
79TNIK0.74826820
80CDC42BPA0.72793736
81MAP3K20.71892908
82ARAF0.71733133
83NUAK10.70654509
84TRPM70.69763155
85MAP3K130.69392845
86HIPK20.69362459
87MAPK130.68905965
88MAP3K40.68130470
89CAMK2G0.67286187
90CAMK2A0.67096806
91FGFR40.67055826
92MAPK120.66048719
93PLK20.65544470
94SIK20.65191635
95MAP3K70.64528782
96PTK60.64504985
97SGK20.63746924
98PDGFRA0.63263117
99CSNK1G10.62721557
100STK30.62039964
101TAOK10.61816405
102FYN0.60211383
103PRKD20.59372794
104PRKCZ0.58489226
105MELK0.57760179
106PRKG10.57720330
107PRKCE0.56451025
108EPHA30.56333319
109PNCK0.55685359
110PRPF4B0.54823886
111MAPKAPK50.54548835
112CDK50.53192806
113GSK3A0.51866273
114PDK10.51747432
115NEK60.51280388
116CDK150.51090199
117FGR0.50877831
118TNK20.50737394
119DYRK1A0.50408089
120IRAK10.50381835
121RPS6KA30.48685163
122MAP2K40.48623563
123CAMK40.48546737
124MOS0.48524514
125MAPK100.48489070
126STK100.47655524
127CDK180.47358041
128CSNK1G20.47267944
129PINK10.46917675
130JAK10.45751663
131CSNK1D0.43898484
132CAMK2B0.43632402
133RET0.41974636
134MARK10.41158164
135MUSK0.40964947
136PKN20.40553461
137CSNK1G30.40254666
138EEF2K0.40145121
139CDK11A0.40027108
140PRKACG0.39428057

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.21274919
2Nicotine addiction_Homo sapiens_hsa050332.49450957
3Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.30965846
4Long-term potentiation_Homo sapiens_hsa047202.23237552
5Dilated cardiomyopathy_Homo sapiens_hsa054141.90046990
6Synaptic vesicle cycle_Homo sapiens_hsa047211.85519572
7Fatty acid biosynthesis_Homo sapiens_hsa000611.85208784
8Amphetamine addiction_Homo sapiens_hsa050311.79596779
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.76240650
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73212693
11Lysine degradation_Homo sapiens_hsa003101.67640240
12PPAR signaling pathway_Homo sapiens_hsa033201.59864687
13Fatty acid metabolism_Homo sapiens_hsa012121.56539678
14Fatty acid elongation_Homo sapiens_hsa000621.54875596
15Type II diabetes mellitus_Homo sapiens_hsa049301.48028437
16Dorso-ventral axis formation_Homo sapiens_hsa043201.46066943
17Steroid biosynthesis_Homo sapiens_hsa001001.43217021
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40134869
19Propanoate metabolism_Homo sapiens_hsa006401.39945150
20Renal cell carcinoma_Homo sapiens_hsa052111.35380533
21Estrogen signaling pathway_Homo sapiens_hsa049151.29936573
22Axon guidance_Homo sapiens_hsa043601.29077751
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.27772791
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23836354
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.22272603
26GnRH signaling pathway_Homo sapiens_hsa049121.18684526
27Thyroid hormone synthesis_Homo sapiens_hsa049181.17934933
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15840536
29Circadian rhythm_Homo sapiens_hsa047101.14377692
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13493347
31Calcium signaling pathway_Homo sapiens_hsa040201.13381178
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10652556
33Ether lipid metabolism_Homo sapiens_hsa005651.08287644
34Fatty acid degradation_Homo sapiens_hsa000711.08146442
35Viral myocarditis_Homo sapiens_hsa054161.07384610
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05062022
37Prion diseases_Homo sapiens_hsa050201.05007412
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04847882
39Butanoate metabolism_Homo sapiens_hsa006501.03272461
40Insulin resistance_Homo sapiens_hsa049311.01885116
41AMPK signaling pathway_Homo sapiens_hsa041521.01866577
42Cardiac muscle contraction_Homo sapiens_hsa042601.01329150
43Fat digestion and absorption_Homo sapiens_hsa049750.94325838
44Neurotrophin signaling pathway_Homo sapiens_hsa047220.93245895
45Histidine metabolism_Homo sapiens_hsa003400.92082631
46Rap1 signaling pathway_Homo sapiens_hsa040150.91512222
47Endometrial cancer_Homo sapiens_hsa052130.88963141
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.88458820
49Inositol phosphate metabolism_Homo sapiens_hsa005620.86749020
50ABC transporters_Homo sapiens_hsa020100.86728453
51Taste transduction_Homo sapiens_hsa047420.85323436
52Glycerolipid metabolism_Homo sapiens_hsa005610.85264668
53GABAergic synapse_Homo sapiens_hsa047270.84323194
54cAMP signaling pathway_Homo sapiens_hsa040240.83932983
55ECM-receptor interaction_Homo sapiens_hsa045120.83424585
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83325488
57Vitamin B6 metabolism_Homo sapiens_hsa007500.82851971
58Tight junction_Homo sapiens_hsa045300.82453768
59Renin secretion_Homo sapiens_hsa049240.82291264
60Sulfur metabolism_Homo sapiens_hsa009200.82093967
61Glutamatergic synapse_Homo sapiens_hsa047240.79337418
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78897498
63Glucagon signaling pathway_Homo sapiens_hsa049220.78281440
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78255676
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.77493165
66Cholinergic synapse_Homo sapiens_hsa047250.77087074
67Malaria_Homo sapiens_hsa051440.76893590
68ErbB signaling pathway_Homo sapiens_hsa040120.75774192
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75354892
70Morphine addiction_Homo sapiens_hsa050320.75296426
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74019493
72mTOR signaling pathway_Homo sapiens_hsa041500.73716062
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73255527
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73222514
75Focal adhesion_Homo sapiens_hsa045100.72596650
76VEGF signaling pathway_Homo sapiens_hsa043700.72221496
77Circadian entrainment_Homo sapiens_hsa047130.71357902
78Cocaine addiction_Homo sapiens_hsa050300.71203771
79Notch signaling pathway_Homo sapiens_hsa043300.70608693
80Proteoglycans in cancer_Homo sapiens_hsa052050.69479631
81Insulin secretion_Homo sapiens_hsa049110.69296156
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68342297
83Gastric acid secretion_Homo sapiens_hsa049710.68320117
84Chronic myeloid leukemia_Homo sapiens_hsa052200.68266789
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.67205797
86Salivary secretion_Homo sapiens_hsa049700.66376856
87Pancreatic secretion_Homo sapiens_hsa049720.65256362
88Sphingolipid metabolism_Homo sapiens_hsa006000.63807656
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63659755
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63526246
91Hippo signaling pathway_Homo sapiens_hsa043900.63474514
92Choline metabolism in cancer_Homo sapiens_hsa052310.62535493
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61365362
94Adherens junction_Homo sapiens_hsa045200.58682647
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58356037
96Wnt signaling pathway_Homo sapiens_hsa043100.58223451
97Endocytosis_Homo sapiens_hsa041440.58140073
98Glioma_Homo sapiens_hsa052140.57487824
99MicroRNAs in cancer_Homo sapiens_hsa052060.57298364
100Insulin signaling pathway_Homo sapiens_hsa049100.56931835
101Ovarian steroidogenesis_Homo sapiens_hsa049130.54538684
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54395024
103Long-term depression_Homo sapiens_hsa047300.54318034
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.53456315
105Platelet activation_Homo sapiens_hsa046110.53429363
106Mineral absorption_Homo sapiens_hsa049780.53194320
107Amoebiasis_Homo sapiens_hsa051460.52961977
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52694276
109MAPK signaling pathway_Homo sapiens_hsa040100.52678413
110Serotonergic synapse_Homo sapiens_hsa047260.51504126
111Vibrio cholerae infection_Homo sapiens_hsa051100.50820524
112Chemokine signaling pathway_Homo sapiens_hsa040620.50812983
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50328483
114Gap junction_Homo sapiens_hsa045400.49979387
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49467850
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48801699
117Prolactin signaling pathway_Homo sapiens_hsa049170.48675108
118Oxytocin signaling pathway_Homo sapiens_hsa049210.48172881
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47729236
120beta-Alanine metabolism_Homo sapiens_hsa004100.47288975
121Non-small cell lung cancer_Homo sapiens_hsa052230.47041193
122Pancreatic cancer_Homo sapiens_hsa052120.46805060
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46432658
124Prostate cancer_Homo sapiens_hsa052150.46362097
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45241021
126Arginine and proline metabolism_Homo sapiens_hsa003300.44733582
127Melanogenesis_Homo sapiens_hsa049160.44004863
128Dopaminergic synapse_Homo sapiens_hsa047280.43395990
129FoxO signaling pathway_Homo sapiens_hsa040680.43050157
130Ras signaling pathway_Homo sapiens_hsa040140.43012018
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42322413
132Bile secretion_Homo sapiens_hsa049760.42309315
133Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41808373
134Systemic lupus erythematosus_Homo sapiens_hsa053220.41674517

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