HIPK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the homeodomain interacting protein kinase (HIPK) family of proteins. While other members of this family are found throughout vertebrates, this member is present only in mammals. Compared to other members of this family, the encoded protein lacks a nuclear localization signal and a C-terminal autoinhibitory domain. The encoded protein exhibits kinase activity and may phosphorylate the tumor suppressor protein p53. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)6.46623994
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.69735230
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.59926315
4L-amino acid import (GO:0043092)5.41486247
5vocalization behavior (GO:0071625)5.38367188
6regulation of retinoic acid receptor signaling pathway (GO:0048385)5.25490409
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.19213291
8locomotory exploration behavior (GO:0035641)5.13644965
9synaptic vesicle maturation (GO:0016188)5.12692005
10neuronal action potential propagation (GO:0019227)5.11644221
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.07952548
12synaptic vesicle docking involved in exocytosis (GO:0016081)5.05767275
13sodium ion export (GO:0071436)5.05538602
14synaptic vesicle exocytosis (GO:0016079)5.05201819
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.97926284
16regulation of glutamate receptor signaling pathway (GO:1900449)4.92716234
17amino acid import (GO:0043090)4.89376910
18glutamate secretion (GO:0014047)4.88088433
19protein localization to synapse (GO:0035418)4.77983245
20regulation of acrosome reaction (GO:0060046)4.73586929
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.70006485
22regulation of synaptic vesicle exocytosis (GO:2000300)4.67360197
23glutamate receptor signaling pathway (GO:0007215)4.52440559
24regulation of neuronal synaptic plasticity (GO:0048168)4.52147141
25synaptic transmission, glutamatergic (GO:0035249)4.41032866
26neuron-neuron synaptic transmission (GO:0007270)4.38117847
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.35917855
28regulation of synapse structural plasticity (GO:0051823)4.34183792
29regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.31545351
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.30104424
31regulation of synaptic vesicle transport (GO:1902803)4.23483882
32neurotransmitter-gated ion channel clustering (GO:0072578)4.19800833
33neurotransmitter secretion (GO:0007269)4.13331463
34regulation of calcium ion-dependent exocytosis (GO:0017158)4.10816949
35exploration behavior (GO:0035640)4.09955786
36regulation of excitatory postsynaptic membrane potential (GO:0060079)4.04258318
37neuron cell-cell adhesion (GO:0007158)3.98706039
38long-term memory (GO:0007616)3.96369632
39regulation of synapse maturation (GO:0090128)3.96339608
40regulation of dendritic spine morphogenesis (GO:0061001)3.87591394
41positive regulation of membrane potential (GO:0045838)3.84114557
42regulation of postsynaptic membrane potential (GO:0060078)3.83358526
43regulation of synaptic plasticity (GO:0048167)3.83317972
44phosphorelay signal transduction system (GO:0000160)3.81310200
45cerebellar granule cell differentiation (GO:0021707)3.80077269
46regulation of female gonad development (GO:2000194)3.79709907
47glycine transport (GO:0015816)3.76552434
48G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.75241981
49long-term synaptic potentiation (GO:0060291)3.72730929
50dendritic spine morphogenesis (GO:0060997)3.69667185
51positive regulation of neurotransmitter transport (GO:0051590)3.69534657
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.68641186
53regulation of synaptic transmission, glutamatergic (GO:0051966)3.67525334
54transmission of nerve impulse (GO:0019226)3.66581335
55cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.64764889
56positive regulation of neurotransmitter secretion (GO:0001956)3.60546491
57protein kinase C signaling (GO:0070528)3.59464532
58gamma-aminobutyric acid signaling pathway (GO:0007214)3.58943876
59negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.58022990
60membrane depolarization during action potential (GO:0086010)3.57797770
61calcium ion-dependent exocytosis (GO:0017156)3.57498235
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.56908586
63gamma-aminobutyric acid transport (GO:0015812)3.56533336
64regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.55763100
65multicellular organism reproduction (GO:0032504)3.55325868
66G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.53577200
67regulation of ARF protein signal transduction (GO:0032012)3.52184998
68positive regulation of dendritic spine morphogenesis (GO:0061003)3.49077017
69neuromuscular synaptic transmission (GO:0007274)3.46653844
70neuromuscular process controlling balance (GO:0050885)3.39598444
71membrane depolarization (GO:0051899)3.39361287
72positive regulation of synaptic transmission, GABAergic (GO:0032230)3.38964819
73striatum development (GO:0021756)3.38337478
74response to histamine (GO:0034776)3.37370171
75cellular potassium ion homeostasis (GO:0030007)3.35980092
76prepulse inhibition (GO:0060134)3.35935077
77neurotransmitter transport (GO:0006836)3.35916545
78behavioral response to cocaine (GO:0048148)3.35403967
79synaptic transmission, dopaminergic (GO:0001963)3.34777173
80auditory behavior (GO:0031223)3.34754651
81behavioral defense response (GO:0002209)3.33257954
82behavioral fear response (GO:0001662)3.33257954
83neuromuscular process controlling posture (GO:0050884)3.33141115
84regulation of neurotransmitter secretion (GO:0046928)3.33011977
85positive regulation of synapse maturation (GO:0090129)3.31735965
86proline transport (GO:0015824)3.29026253
87neuron recognition (GO:0008038)3.27624166
88retinal cone cell development (GO:0046549)3.27427503
89regulation of exocytosis (GO:0017157)3.27066144
90positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.25580526
91chemosensory behavior (GO:0007635)3.25054898
92regulation of dendritic spine development (GO:0060998)3.23749020
93layer formation in cerebral cortex (GO:0021819)3.23668651
94neuronal ion channel clustering (GO:0045161)3.22959366
95activation of protein kinase A activity (GO:0034199)3.22639111
96regulation of vesicle fusion (GO:0031338)3.22608776
97response to auditory stimulus (GO:0010996)3.22306058
98learning (GO:0007612)3.21311183
99sleep (GO:0030431)3.20299332
100regulation of glutamate secretion (GO:0014048)3.19951670
101cytoskeletal anchoring at plasma membrane (GO:0007016)3.17227790
102synaptic vesicle endocytosis (GO:0048488)3.17128284
103regulation of protein kinase A signaling (GO:0010738)3.16674035
104regulation of neurotransmitter transport (GO:0051588)3.16168061
105positive regulation of exocytosis (GO:0045921)3.14861526
106membrane hyperpolarization (GO:0060081)3.13131720
107cerebellar Purkinje cell differentiation (GO:0021702)3.12624066
108response to amphetamine (GO:0001975)3.12609949
109potassium ion homeostasis (GO:0055075)3.12525688
110regulation of neurotransmitter levels (GO:0001505)3.12212125
111startle response (GO:0001964)3.12103218
112fear response (GO:0042596)3.12030826
113serotonin metabolic process (GO:0042428)3.10598183
114positive regulation of synaptic transmission (GO:0050806)3.10381848
115cell communication by electrical coupling (GO:0010644)3.10041805
116regulation of female receptivity (GO:0045924)3.09750377
117dendritic spine organization (GO:0097061)3.09486680
118long term synaptic depression (GO:0060292)3.09413000
119response to acidic pH (GO:0010447)3.08266548
120presynaptic membrane assembly (GO:0097105)3.08021871
121vesicle docking involved in exocytosis (GO:0006904)3.06841219
122synaptic transmission (GO:0007268)3.06701349
123postsynaptic membrane organization (GO:0001941)3.06145143
124neuromuscular process (GO:0050905)3.04694964
125regulation of synaptic transmission (GO:0050804)3.03798596
126regulation of voltage-gated calcium channel activity (GO:1901385)3.03382720
127potassium ion import (GO:0010107)3.02138679
128negative regulation of dendrite morphogenesis (GO:0050774)2.99658701
129axonal fasciculation (GO:0007413)2.99071744
130regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.97725169
131positive regulation of dendritic spine development (GO:0060999)2.96686357
132cAMP catabolic process (GO:0006198)2.95579274
133visual learning (GO:0008542)2.95471356
134regulation of DNA methylation (GO:0044030)2.91563073

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.52033356
2GBX2_23144817_ChIP-Seq_PC3_Human3.74046743
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00205914
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84676482
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.83944070
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.77761171
7REST_21632747_ChIP-Seq_MESCs_Mouse2.71586307
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.63883378
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52446080
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50556186
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50556186
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44163881
13DROSHA_22980978_ChIP-Seq_HELA_Human2.41605772
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40263581
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37744422
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36031029
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.33771129
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29054456
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14635925
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.09347663
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08838929
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.08256645
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.07565736
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.05992761
25TAF15_26573619_Chip-Seq_HEK293_Human2.04853072
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97308537
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.92364935
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.89888808
29ZFP281_18757296_ChIP-ChIP_E14_Mouse1.89215860
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88050633
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87018801
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86433276
33CTCF_27219007_Chip-Seq_Bcells_Human1.79458136
34LXR_22292898_ChIP-Seq_THP-1_Human1.77467473
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77110156
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76648780
37KDM2B_26808549_Chip-Seq_K562_Human1.75076324
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74937248
39SMAD4_21799915_ChIP-Seq_A2780_Human1.74878844
40EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.71610817
41AR_21572438_ChIP-Seq_LNCaP_Human1.64687295
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.63825676
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63539327
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61068761
45* P68_20966046_ChIP-Seq_HELA_Human1.60518353
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55200611
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54529489
48SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.54034133
49* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.53228116
50SRY_22984422_ChIP-ChIP_TESTIS_Rat1.52955819
51TET1_21490601_ChIP-Seq_MESCs_Mouse1.52106189
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50600153
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.48329432
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47886143
55P300_19829295_ChIP-Seq_ESCs_Human1.47768162
56* OCT4_19829295_ChIP-Seq_ESCs_Human1.47389484
57SMC4_20622854_ChIP-Seq_HELA_Human1.46026391
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.45381646
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44209760
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.42243493
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41297009
62ZNF274_21170338_ChIP-Seq_K562_Hela1.40686080
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.39651749
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32675977
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.30672255
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.29689118
67AR_25329375_ChIP-Seq_VCAP_Human1.28755176
68* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27675076
69* KLF4_19829295_ChIP-Seq_ESCs_Human1.26826269
70STAT3_23295773_ChIP-Seq_U87_Human1.26366261
71ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24167098
72FUS_26573619_Chip-Seq_HEK293_Human1.22316429
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21608243
74SOX2_21211035_ChIP-Seq_LN229_Gbm1.21287319
75TCF4_23295773_ChIP-Seq_U87_Human1.19140299
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.18044728
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17342741
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17205143
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17127421
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.16967677
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15342902
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14191340
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14122351
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14090199
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13555730
86SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13522176
87* CTCF_20526341_ChIP-Seq_ESCs_Human1.13106375
88VDR_22108803_ChIP-Seq_LS180_Human1.12440245
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.11285938
90AR_19668381_ChIP-Seq_PC3_Human1.11103066
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10098528
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09752281
93POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09589521
94SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09030184
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08960433
96RNF2_27304074_Chip-Seq_NSC_Mouse1.08945772
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07381607
98WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06403367
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06035143
100P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05814354
101SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05516601
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04997419
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04755188
104NANOG_18555785_Chip-Seq_ESCs_Mouse1.04473037
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.03574663
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02680539
107RUNX2_22187159_ChIP-Seq_PCA_Human1.00941474
108PRDM14_20953172_ChIP-Seq_ESCs_Human0.99810753
109ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99626364
110* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99224766
111CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98986183
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98171211
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97896168
114RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97867994
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.97200488
116SA1_27219007_Chip-Seq_ERYTHROID_Human0.97075826
117BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96581829
118CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96541016
119YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96098982
120KDM2B_26808549_Chip-Seq_DND41_Human0.95303234
121TP63_22573176_ChIP-Seq_HFKS_Human0.95268243
122OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95246780
123NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94385215
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94373260
125SMAD3_21741376_ChIP-Seq_ESCs_Human0.94218790
126KDM2B_26808549_Chip-Seq_REH_Human0.94037986
127AHR_22903824_ChIP-Seq_MCF-7_Human0.93863343
128TP53_16413492_ChIP-PET_HCT116_Human0.93826582
129GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93423529
130RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92847319
131E2F1_18555785_Chip-Seq_ESCs_Mouse0.92657601
132STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.92227994
133JUN_21703547_ChIP-Seq_K562_Human0.92018319
134TP53_23651856_ChIP-Seq_MEFs_Mouse0.91982890
135RING1B_27294783_Chip-Seq_NPCs_Mouse0.91938770
136CREB1_26743006_Chip-Seq_LNCaP_Human0.91789980
137TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90572974
138SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90449831
139P53_22387025_ChIP-Seq_ESCs_Mouse0.89576898
140CBP_20019798_ChIP-Seq_JUKART_Human0.89460339
141IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89460339
142RUNX1_26923725_Chip-Seq_HPCs_Mouse0.89230789
143LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88662308
144CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88405684
145BCAT_22108803_ChIP-Seq_LS180_Human0.87157702
146SOX9_26525672_Chip-Seq_HEART_Mouse0.87103724
147MYC_27129775_Chip-Seq_CORNEA_Mouse0.86230736
148TP53_20018659_ChIP-ChIP_R1E_Mouse0.86212628
149* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.85784918
150SA1_27219007_Chip-Seq_Bcells_Human0.85447005
151TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.85305415
152MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.84909177
153RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84424843
154* BCOR_27268052_Chip-Seq_Bcells_Human0.83094401
155FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82813853
156GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82654808
157NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81295695
158DPY_21335234_ChIP-Seq_ESCs_Mouse0.81184456
159ELF1_20517297_ChIP-Seq_JURKAT_Human0.80577157
160* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.80443238
161SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80011354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.63637078
2MP0003880_abnormal_central_pattern5.22344282
3MP0002822_catalepsy4.46433996
4MP0003635_abnormal_synaptic_transmissio4.21342363
5MP0009745_abnormal_behavioral_response3.69923427
6MP0004270_analgesia3.67752229
7MP0002063_abnormal_learning/memory/cond3.42271479
8MP0002064_seizures3.24875678
9MP0009046_muscle_twitch3.19254462
10MP0001968_abnormal_touch/_nociception3.14458542
11MP0002572_abnormal_emotion/affect_behav2.89941069
12MP0002272_abnormal_nervous_system2.74348133
13MP0001486_abnormal_startle_reflex2.72574174
14MP0001986_abnormal_taste_sensitivity2.61393879
15MP0002736_abnormal_nociception_after2.57616960
16MP0002734_abnormal_mechanical_nocicepti2.43802902
17MP0001501_abnormal_sleep_pattern2.41200386
18MP0005423_abnormal_somatic_nervous2.24983290
19MP0005410_abnormal_fertilization2.17151952
20MP0002735_abnormal_chemical_nociception2.11091563
21MP0001440_abnormal_grooming_behavior2.10220194
22MP0001529_abnormal_vocalization1.91996389
23MP0002067_abnormal_sensory_capabilities1.89178289
24MP0001970_abnormal_pain_threshold1.87949140
25MP0002733_abnormal_thermal_nociception1.84786703
26MP0005646_abnormal_pituitary_gland1.84669961
27MP0008569_lethality_at_weaning1.82490402
28MP0004924_abnormal_behavior1.71107228
29MP0005386_behavior/neurological_phenoty1.71107228
30MP0003879_abnormal_hair_cell1.69434024
31MP0001984_abnormal_olfaction1.67542881
32MP0002557_abnormal_social/conspecific_i1.66107304
33MP0003787_abnormal_imprinting1.61610748
34MP0004811_abnormal_neuron_physiology1.60353112
35MP0002909_abnormal_adrenal_gland1.54387657
36MP0003718_maternal_effect1.53646303
37MP0001188_hyperpigmentation1.48994837
38MP0003329_amyloid_beta_deposits1.48274170
39MP0004858_abnormal_nervous_system1.47598933
40MP0009780_abnormal_chondrocyte_physiolo1.47273713
41MP0002184_abnormal_innervation1.46895414
42MP0003123_paternal_imprinting1.38527631
43MP0000778_abnormal_nervous_system1.36376434
44MP0002066_abnormal_motor_capabilities/c1.34424212
45MP0003633_abnormal_nervous_system1.33001858
46MP0006276_abnormal_autonomic_nervous1.31738403
47MP0000955_abnormal_spinal_cord1.31323174
48MP0001905_abnormal_dopamine_level1.30574026
49MP0002882_abnormal_neuron_morphology1.25251905
50MP0004142_abnormal_muscle_tone1.21918851
51MP0005409_darkened_coat_color1.19735858
52MP0004130_abnormal_muscle_cell1.18831840
53MP0008872_abnormal_physiological_respon1.16257202
54MP0001346_abnormal_lacrimal_gland1.15474185
55MP0003631_nervous_system_phenotype1.09675762
56MP0000749_muscle_degeneration1.08893241
57MP0001502_abnormal_circadian_rhythm1.08278481
58MP0004145_abnormal_muscle_electrophysio1.07424049
59MP0008874_decreased_physiological_sensi1.04427297
60MP0004885_abnormal_endolymph1.00320611
61MP0001177_atelectasis0.99250506
62MP0000751_myopathy0.98831909
63MP0002152_abnormal_brain_morphology0.97018952
64MP0003075_altered_response_to0.96481039
65MP0005645_abnormal_hypothalamus_physiol0.96288576
66MP0000747_muscle_weakness0.94286353
67MP0004085_abnormal_heartbeat0.93403485
68MP0005670_abnormal_white_adipose0.92270401
69MP0003698_abnormal_male_reproductive0.90144075
70MP0002069_abnormal_eating/drinking_beha0.88924183
71MP0003122_maternal_imprinting0.88668467
72MP0000759_abnormal_skeletal_muscle0.84741896
73MP0005171_absent_coat_pigmentation0.83836139
74MP0002229_neurodegeneration0.83251641
75MP0005535_abnormal_body_temperature0.81908844
76MP0008877_abnormal_DNA_methylation0.80891037
77MP0005551_abnormal_eye_electrophysiolog0.79314554
78MP0001963_abnormal_hearing_physiology0.78778137
79MP0004742_abnormal_vestibular_system0.77842483
80MP0000013_abnormal_adipose_tissue0.77493211
81MP0001485_abnormal_pinna_reflex0.76947950
82MP0006292_abnormal_olfactory_placode0.76885282
83MP0004484_altered_response_of0.75600678
84MP0010386_abnormal_urinary_bladder0.73663215
85MP0002837_dystrophic_cardiac_calcinosis0.73645585
86MP0004510_myositis0.72706507
87MP0000750_abnormal_muscle_regeneration0.71448731
88MP0008260_abnormal_autophagy0.71416507
89MP0000920_abnormal_myelination0.70995117
90MP0000569_abnormal_digit_pigmentation0.70389282
91MP0001664_abnormal_digestion0.69054980
92MP0005167_abnormal_blood-brain_barrier0.68849430
93MP0004215_abnormal_myocardial_fiber0.68452123
94MP0002161_abnormal_fertility/fecundity0.68338224
95MP0005499_abnormal_olfactory_system0.67987806
96MP0005394_taste/olfaction_phenotype0.67987806
97MP0005623_abnormal_meninges_morphology0.67196918
98MP0002876_abnormal_thyroid_physiology0.67055806
99MP0010234_abnormal_vibrissa_follicle0.67006356
100MP0000733_abnormal_muscle_development0.66731311
101MP0003690_abnormal_glial_cell0.66260487
102MP0004036_abnormal_muscle_relaxation0.64885452
103MP0002249_abnormal_larynx_morphology0.64807731
104MP0008961_abnormal_basal_metabolism0.64113026
105MP0001765_abnormal_ion_homeostasis0.63686296
106MP0003632_abnormal_nervous_system0.63595809
107MP0002089_abnormal_postnatal_growth/wei0.62151244
108MP0002106_abnormal_muscle_physiology0.60698287
109MP0000631_abnormal_neuroendocrine_gland0.60191067
110MP0001929_abnormal_gametogenesis0.60170290
111MP0004087_abnormal_muscle_fiber0.59679762
112MP0002752_abnormal_somatic_nervous0.59642071
113MP0010030_abnormal_orbit_morphology0.59562942
114MP0000604_amyloidosis0.59309582
115MP0003634_abnormal_glial_cell0.58440411
116MP0004233_abnormal_muscle_weight0.57788466
117MP0002269_muscular_atrophy0.57085163
118MP0002873_normal_phenotype0.56353904
119MP0002169_no_abnormal_phenotype0.55153350
120MP0003646_muscle_fatigue0.55052498
121MP0003283_abnormal_digestive_organ0.54006295
122MP0004043_abnormal_pH_regulation0.53079840
123MP0003699_abnormal_female_reproductive0.53016669
124MP0002160_abnormal_reproductive_system0.52946170
125MP0003121_genomic_imprinting0.52794487
126MP0001943_abnormal_respiration0.51737512
127MP0003137_abnormal_impulse_conducting0.51383820
128MP0005620_abnormal_muscle_contractility0.49059522

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.17729678
2Myokymia (HP:0002411)7.29716111
3Focal seizures (HP:0007359)6.31977959
4Atonic seizures (HP:0010819)5.21102609
5Epileptic encephalopathy (HP:0200134)5.20278725
6Febrile seizures (HP:0002373)5.10555540
7Visual hallucinations (HP:0002367)4.42569010
8Absence seizures (HP:0002121)4.30809990
9Progressive cerebellar ataxia (HP:0002073)4.07216214
10Dialeptic seizures (HP:0011146)4.05590425
11Absent/shortened dynein arms (HP:0200106)4.04440235
12Dynein arm defect of respiratory motile cilia (HP:0012255)4.04440235
13Generalized tonic-clonic seizures (HP:0002069)4.01289553
14Akinesia (HP:0002304)3.91403906
15Gaze-evoked nystagmus (HP:0000640)3.75611228
16Hyperventilation (HP:0002883)3.75052617
17Broad-based gait (HP:0002136)3.64812979
18Poor eye contact (HP:0000817)3.61564443
19Action tremor (HP:0002345)3.51475490
20Impaired vibration sensation in the lower limbs (HP:0002166)3.49256853
21Popliteal pterygium (HP:0009756)3.35891469
22Obstructive sleep apnea (HP:0002870)3.28618835
23Dysdiadochokinesis (HP:0002075)3.24210146
24Amblyopia (HP:0000646)3.17494040
25Abnormal social behavior (HP:0012433)3.16464279
26Impaired social interactions (HP:0000735)3.16464279
27Apathy (HP:0000741)3.12950589
28Dysmetria (HP:0001310)3.08420115
29Truncal ataxia (HP:0002078)3.07107496
30Urinary bladder sphincter dysfunction (HP:0002839)2.97973449
31Anxiety (HP:0000739)2.95201915
32Cerebral hypomyelination (HP:0006808)2.93947018
33Muscle stiffness (HP:0003552)2.93649177
34Depression (HP:0000716)2.92310883
35Supranuclear gaze palsy (HP:0000605)2.91641033
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.90670665
37Impaired smooth pursuit (HP:0007772)2.90583501
38Ankle clonus (HP:0011448)2.89360601
39Aplasia of the musculature (HP:0100854)2.84933896
40Diminished motivation (HP:0000745)2.77356235
41Neuronal loss in central nervous system (HP:0002529)2.77042480
42Postural instability (HP:0002172)2.74773370
43Scanning speech (HP:0002168)2.74080623
44Hemiparesis (HP:0001269)2.73643381
45Abnormal eating behavior (HP:0100738)2.73271661
46Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.64943912
47Torticollis (HP:0000473)2.63743586
48Urinary urgency (HP:0000012)2.63103476
49Male infertility (HP:0003251)2.62500802
50Dysmetric saccades (HP:0000641)2.62011797
51Abnormal respiratory motile cilium physiology (HP:0012261)2.58671572
52Abnormality of the lower motor neuron (HP:0002366)2.56542779
53Hyporeflexia of lower limbs (HP:0002600)2.56107468
54Muscle fiber inclusion bodies (HP:0100299)2.55306384
55Stereotypic behavior (HP:0000733)2.54056380
56Status epilepticus (HP:0002133)2.52353999
57Impaired vibratory sensation (HP:0002495)2.51157701
58Heart block (HP:0012722)2.50275913
59Annular pancreas (HP:0001734)2.50273565
60Diminished movement (HP:0002374)2.50076025
61Tetraplegia (HP:0002445)2.49937896
62Abnormal respiratory epithelium morphology (HP:0012253)2.48695176
63Abnormal respiratory motile cilium morphology (HP:0005938)2.48695176
64Abnormality of ocular smooth pursuit (HP:0000617)2.47652081
65Absent speech (HP:0001344)2.45773210
66Genetic anticipation (HP:0003743)2.45282472
67Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.44248009
68Focal dystonia (HP:0004373)2.43009570
69Abnormal atrioventricular conduction (HP:0005150)2.41931285
70Resting tremor (HP:0002322)2.41841124
71Cutaneous melanoma (HP:0012056)2.40762562
72Round ear (HP:0100830)2.38127230
73Abnormal ciliary motility (HP:0012262)2.37022315
74Epileptiform EEG discharges (HP:0011182)2.36325051
75Rigidity (HP:0002063)2.36171631
76Drooling (HP:0002307)2.34316843
77Excessive salivation (HP:0003781)2.34316843
78Upper limb amyotrophy (HP:0009129)2.32277583
79Distal upper limb amyotrophy (HP:0007149)2.32277583
80Distal lower limb muscle weakness (HP:0009053)2.31702943
81Nemaline bodies (HP:0003798)2.30499176
82Type 1 muscle fiber predominance (HP:0003803)2.30086960
83Hand muscle atrophy (HP:0009130)2.29820065
84Bradykinesia (HP:0002067)2.28030027
85Spastic gait (HP:0002064)2.26084264
86Progressive inability to walk (HP:0002505)2.25894642
87Malignant hyperthermia (HP:0002047)2.25198724
88Type 2 muscle fiber atrophy (HP:0003554)2.23274237
89Hypercortisolism (HP:0001578)2.22930315
90Ulnar deviation of the wrist (HP:0003049)2.22027224
91Inability to walk (HP:0002540)2.21642037
92Limb dystonia (HP:0002451)2.21348428
93Fetal akinesia sequence (HP:0001989)2.20963692
94Diplopia (HP:0000651)2.20187442
95Abnormality of binocular vision (HP:0011514)2.20187442
96Craniofacial dystonia (HP:0012179)2.18375436
97Termporal pattern (HP:0011008)2.14166890
98Insidious onset (HP:0003587)2.14166890
99Muscle fiber splitting (HP:0003555)2.14065254
100Insomnia (HP:0100785)2.10835410
101EEG with generalized epileptiform discharges (HP:0011198)2.09900325
102Anterior segment dysgenesis (HP:0007700)2.09079049
103Hemiplegia (HP:0002301)2.07630659
104Intention tremor (HP:0002080)2.07008736
105Sudden death (HP:0001699)2.07000733
106Ventricular fibrillation (HP:0001663)2.06627880
107Abnormality of placental membranes (HP:0011409)2.05888387
108Amniotic constriction ring (HP:0009775)2.05888387
109Cerebral inclusion bodies (HP:0100314)2.05753593
110Blue irides (HP:0000635)2.05448519
111Asymmetric septal hypertrophy (HP:0001670)2.04637121
112Incomplete penetrance (HP:0003829)2.04194556
113Lower limb amyotrophy (HP:0007210)2.04031972
114Neurofibrillary tangles (HP:0002185)2.01453466
115Muscle fiber atrophy (HP:0100295)2.01109441
116Exercise-induced myalgia (HP:0003738)2.00398929
117Protruding tongue (HP:0010808)1.99478904
118Lower limb muscle weakness (HP:0007340)1.97156808
119Spinal cord compression (HP:0002176)1.95980931
120Myotonia (HP:0002486)1.95309100
121Rhinitis (HP:0012384)1.95029010
122Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.94743879
123Generalized myoclonic seizures (HP:0002123)1.94174809
124Gait ataxia (HP:0002066)1.94119699
125Gait imbalance (HP:0002141)1.93122017
126Lower limb asymmetry (HP:0100559)1.93097651
127Bundle branch block (HP:0011710)1.92992177
128Hypsarrhythmia (HP:0002521)1.92619756
129Myopathic facies (HP:0002058)1.92550928
130Clonus (HP:0002169)1.92468973
131Spinal canal stenosis (HP:0003416)1.92438632
132Medial flaring of the eyebrow (HP:0010747)1.90649067
133Abnormal EKG (HP:0003115)1.90211098
134Pointed chin (HP:0000307)1.88740900
135Infertility (HP:0000789)1.88367843
136Fatigable weakness (HP:0003473)1.87799308
137Abnormality of the neuromuscular junction (HP:0003398)1.87799308
138Abnormality of saccadic eye movements (HP:0000570)1.86560247
139Megalencephaly (HP:0001355)1.85266401
140Papilledema (HP:0001085)1.84073815
141Deeply set eye (HP:0000490)1.80548648
142Mutism (HP:0002300)1.79733773
143Congenital primary aphakia (HP:0007707)1.77843282
144Delusions (HP:0000746)1.77724226
145Prolonged QT interval (HP:0001657)1.77232262
146Retinal dysplasia (HP:0007973)1.74023033
147Pheochromocytoma (HP:0002666)1.71885069
148Abnormality of the corticospinal tract (HP:0002492)1.69447369
149Specific learning disability (HP:0001328)1.69029948

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.72303441
2NTRK34.65461202
3RIPK43.20336250
4PRKD33.14997230
5MAP3K93.07722712
6MAP3K42.85425760
7DAPK22.69013096
8LATS22.58046336
9MAP2K72.56280129
10MINK12.24191980
11CASK2.19203156
12MAP3K121.98629655
13DAPK11.93777306
14KSR21.93237031
15PAK61.84245156
16MAP2K41.81397738
17CAMKK11.78781407
18TNIK1.67639861
19PLK21.56944165
20NTRK11.55683796
21ARAF1.55515167
22NTRK21.54953395
23PRPF4B1.52601946
24BMPR21.49178192
25CDK191.48149028
26STK381.48032681
27CDK51.47707376
28PTK2B1.44786420
29FES1.40779107
30KSR11.40193635
31MARK11.30258474
32PNCK1.27004555
33MAP3K131.26677455
34PRKCG1.24329830
35CDK121.23433356
36PDK31.19119315
37PDK41.19119315
38GRK51.13844594
39AKT31.12734285
40TESK11.11531975
41RIPK11.10255248
42MAPK131.09802042
43PHKG11.09366145
44SIK21.08886409
45CAMK2A1.05055785
46CAMKK21.03386082
47TYRO31.01105335
48MOS1.00928663
49MAP3K20.99526079
50CAMK2B0.95902457
51RAF10.91893661
52SGK4940.91123462
53SGK2230.91123462
54SGK20.90595765
55OXSR10.90181765
56CAMK10.89473775
57PINK10.89426686
58MAP3K110.89053229
59MAPK120.86646589
60LIMK10.84137257
61TNK20.83426938
62TESK20.82876940
63TAOK10.82863252
64CDK180.80270071
65PDK10.78228602
66CDK150.77814856
67SGK10.76971408
68NEK60.76849507
69AURKA0.75574608
70PRKCH0.75556689
71STK110.74948684
72PKN10.74597888
73CCNB10.74573187
74PDPK10.72770535
75UHMK10.72291095
76PRKG20.71936185
77CDK140.70734632
78SGK30.68330025
79PDK20.67575488
80WNK10.67412275
81OBSCN0.67255158
82CDK11A0.67012376
83BRAF0.65031650
84NME10.62221535
85TRIB30.56802084
86MAP3K10.56192772
87MARK20.53511086
88TAOK20.53124171
89ALK0.53083862
90PRKCE0.52042382
91FGR0.52019462
92RET0.51842306
93PAK10.50557089
94CAMK2G0.49888700
95CAMK2D0.48365536
96LMTK20.47802277
97DYRK1A0.46878352
98RPS6KA30.46021377
99MAP2K10.45749606
100DAPK30.45572310
101CAMK1D0.44994917
102PAK30.44638731
103STK390.43403894
104WNK40.40015459
105CAMK40.39691364
106MAPK100.39483885
107PRKCZ0.39306331
108CDC42BPA0.38271755
109MAP3K70.37582188
110ROCK10.37444957
111BRSK10.37444211
112FER0.37374376
113ICK0.37024675
114PTK20.35976314
115PRKG10.35201064
116FYN0.34762285
117AKT20.34435864
118CAMK1G0.32554034
119PRKCB0.32167734
120PRKCI0.32127118
121MUSK0.31947919
122DMPK0.31603742
123PRKCA0.31547696
124PRKD20.31245616
125PHKG20.30533945
126BRD40.27926076
127GSK3B0.26600680
128MAPK40.26042056
129BMX0.25271759
130MAPK110.24634360
131CSNK1D0.23885045

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.87853241
2Synaptic vesicle cycle_Homo sapiens_hsa047213.12975836
3Olfactory transduction_Homo sapiens_hsa047403.04946080
4Long-term potentiation_Homo sapiens_hsa047202.95748658
5Circadian entrainment_Homo sapiens_hsa047132.87963101
6Amphetamine addiction_Homo sapiens_hsa050312.86029898
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75665012
8Morphine addiction_Homo sapiens_hsa050322.70214757
9Glutamatergic synapse_Homo sapiens_hsa047242.69668120
10GABAergic synapse_Homo sapiens_hsa047272.61488344
11Salivary secretion_Homo sapiens_hsa049702.32291048
12Dopaminergic synapse_Homo sapiens_hsa047282.24616236
13Insulin secretion_Homo sapiens_hsa049112.02481430
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00632220
15Taste transduction_Homo sapiens_hsa047421.95640338
16Gastric acid secretion_Homo sapiens_hsa049711.91361862
17Calcium signaling pathway_Homo sapiens_hsa040201.90194849
18Renin secretion_Homo sapiens_hsa049241.90120053
19Cholinergic synapse_Homo sapiens_hsa047251.89516653
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.86649159
21Cocaine addiction_Homo sapiens_hsa050301.77864982
22Oxytocin signaling pathway_Homo sapiens_hsa049211.76772140
23Serotonergic synapse_Homo sapiens_hsa047261.70976166
24Collecting duct acid secretion_Homo sapiens_hsa049661.67989143
25Long-term depression_Homo sapiens_hsa047301.67581111
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67168541
27GnRH signaling pathway_Homo sapiens_hsa049121.41745183
28cAMP signaling pathway_Homo sapiens_hsa040241.40800855
29Vitamin B6 metabolism_Homo sapiens_hsa007501.37999768
30Gap junction_Homo sapiens_hsa045401.31607847
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31570983
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30426875
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21704785
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18670771
35cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16060248
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15417983
37Cardiac muscle contraction_Homo sapiens_hsa042601.14923290
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13522708
39Estrogen signaling pathway_Homo sapiens_hsa049151.06285230
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.04212344
41Glioma_Homo sapiens_hsa052141.00178225
42Melanogenesis_Homo sapiens_hsa049161.00119302
43Type II diabetes mellitus_Homo sapiens_hsa049300.98227571
44Oocyte meiosis_Homo sapiens_hsa041140.95075884
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93954336
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.93450096
47ErbB signaling pathway_Homo sapiens_hsa040120.92083160
48Vibrio cholerae infection_Homo sapiens_hsa051100.91966295
49Pancreatic secretion_Homo sapiens_hsa049720.91365013
50Axon guidance_Homo sapiens_hsa043600.88353234
51Dorso-ventral axis formation_Homo sapiens_hsa043200.81282890
52Phototransduction_Homo sapiens_hsa047440.80712663
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80649823
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.78529076
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77572519
56Glucagon signaling pathway_Homo sapiens_hsa049220.77505976
57Thyroid hormone synthesis_Homo sapiens_hsa049180.76550690
58Nitrogen metabolism_Homo sapiens_hsa009100.75726542
59Regulation of autophagy_Homo sapiens_hsa041400.74300043
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73184812
61Dilated cardiomyopathy_Homo sapiens_hsa054140.72797869
62Choline metabolism in cancer_Homo sapiens_hsa052310.68084617
63MAPK signaling pathway_Homo sapiens_hsa040100.67734624
64VEGF signaling pathway_Homo sapiens_hsa043700.60897413
65Arginine and proline metabolism_Homo sapiens_hsa003300.58412389
66Alzheimers disease_Homo sapiens_hsa050100.57970334
67African trypanosomiasis_Homo sapiens_hsa051430.57745488
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57738990
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57583980
70Rap1 signaling pathway_Homo sapiens_hsa040150.57158931
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56852162
72Arginine biosynthesis_Homo sapiens_hsa002200.55168859
73Insulin signaling pathway_Homo sapiens_hsa049100.54542708
74Inositol phosphate metabolism_Homo sapiens_hsa005620.54089510
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52744161
76Ras signaling pathway_Homo sapiens_hsa040140.52018601
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49794022
78Alcoholism_Homo sapiens_hsa050340.47908384
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47327617
80Tight junction_Homo sapiens_hsa045300.44916512
81Type I diabetes mellitus_Homo sapiens_hsa049400.44239986
82Circadian rhythm_Homo sapiens_hsa047100.42832431
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42282007
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.41111516
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40699978
86Hippo signaling pathway_Homo sapiens_hsa043900.40571045
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40394780
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.40247630
89Bile secretion_Homo sapiens_hsa049760.39996778
90Wnt signaling pathway_Homo sapiens_hsa043100.39182718
91Oxidative phosphorylation_Homo sapiens_hsa001900.38814362
92AMPK signaling pathway_Homo sapiens_hsa041520.37743294
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33228074
94Non-small cell lung cancer_Homo sapiens_hsa052230.33169983
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33093961
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32837748
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32805505
98Endocytosis_Homo sapiens_hsa041440.32598311
99Ovarian steroidogenesis_Homo sapiens_hsa049130.32031335
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.31199059
101Parkinsons disease_Homo sapiens_hsa050120.30624096
102Fatty acid biosynthesis_Homo sapiens_hsa000610.29202929
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29082476
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28905333
105mTOR signaling pathway_Homo sapiens_hsa041500.28375309
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27716159
107HIF-1 signaling pathway_Homo sapiens_hsa040660.27513766
108Rheumatoid arthritis_Homo sapiens_hsa053230.24712566
109Chemokine signaling pathway_Homo sapiens_hsa040620.24073832
110Prion diseases_Homo sapiens_hsa050200.23940572
111Mineral absorption_Homo sapiens_hsa049780.23897486
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.22503497
113Endometrial cancer_Homo sapiens_hsa052130.22301608

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