HIRA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.42287073
2negative regulation of erythrocyte differentiation (GO:0045647)4.94715489
3nuclear pore complex assembly (GO:0051292)4.52886695
4protein localization to kinetochore (GO:0034501)4.51347749
5DNA unwinding involved in DNA replication (GO:0006268)4.50857322
6nuclear pore organization (GO:0006999)4.47207037
7regulation of translational fidelity (GO:0006450)4.41811541
8negative regulation of histone methylation (GO:0031061)4.18345194
9heterochromatin organization (GO:0070828)4.07285342
10regulation of translational termination (GO:0006449)4.01667148
11sister chromatid segregation (GO:0000819)4.00342667
12COPI coating of Golgi vesicle (GO:0048205)3.96271298
13Golgi transport vesicle coating (GO:0048200)3.96271298
14regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.96090372
15negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.93022337
16proline biosynthetic process (GO:0006561)3.81736311
17mitotic sister chromatid segregation (GO:0000070)3.78956910
18mitotic sister chromatid cohesion (GO:0007064)3.77061011
19regulation of RNA export from nucleus (GO:0046831)3.76936534
20mitotic nuclear envelope disassembly (GO:0007077)3.75829480
21regulation of early endosome to late endosome transport (GO:2000641)3.72280907
22regulation of histone H3-K27 methylation (GO:0061085)3.69177547
233-UTR-mediated mRNA stabilization (GO:0070935)3.69013687
24regulation of hippo signaling (GO:0035330)3.68183400
25nuclear envelope disassembly (GO:0051081)3.67798031
26membrane disassembly (GO:0030397)3.67798031
27peptidyl-lysine dimethylation (GO:0018027)3.64391696
28spliceosomal tri-snRNP complex assembly (GO:0000244)3.59012382
29DNA duplex unwinding (GO:0032508)3.56077436
30protein localization to chromosome, centromeric region (GO:0071459)3.54179505
31folic acid-containing compound biosynthetic process (GO:0009396)3.53379204
32DNA geometric change (GO:0032392)3.52953734
33regulation of sister chromatid cohesion (GO:0007063)3.48377767
34negative regulation of RNA splicing (GO:0033119)3.46818971
35dosage compensation (GO:0007549)3.45707910
36RNA stabilization (GO:0043489)3.43409723
37mRNA stabilization (GO:0048255)3.43409723
38histone H2A monoubiquitination (GO:0035518)3.43294128
39protein localization to endosome (GO:0036010)3.35364656
40peptidyl-arginine omega-N-methylation (GO:0035247)3.35237018
41regulation of histone H3-K9 methylation (GO:0051570)3.34989622
42chromatin assembly (GO:0031497)3.34202106
43glucocorticoid receptor signaling pathway (GO:0042921)3.32033858
44mitotic G1 DNA damage checkpoint (GO:0031571)3.28996109
45negative regulation of mRNA processing (GO:0050686)3.27623491
46regulation of posttranscriptional gene silencing (GO:0060147)3.22940580
47regulation of gene silencing by miRNA (GO:0060964)3.22940580
48regulation of gene silencing by RNA (GO:0060966)3.22940580
49apoptotic process involved in morphogenesis (GO:0060561)3.22654711
50NLS-bearing protein import into nucleus (GO:0006607)3.20293072
51protein export from nucleus (GO:0006611)3.19146152
52positive regulation of chromosome segregation (GO:0051984)3.18788020
53mitotic chromosome condensation (GO:0007076)3.18082953
54peptidyl-arginine methylation (GO:0018216)3.16547919
55peptidyl-arginine N-methylation (GO:0035246)3.16547919
56pore complex assembly (GO:0046931)3.15868400
57negative regulation of mRNA metabolic process (GO:1903312)3.15431285
58cytoplasmic mRNA processing body assembly (GO:0033962)3.14507389
59embryonic process involved in female pregnancy (GO:0060136)3.13862270
60nuclear envelope organization (GO:0006998)3.13216422
61regulation of nucleobase-containing compound transport (GO:0032239)3.12097222
62positive regulation of RNA splicing (GO:0033120)3.08869291
63mannose metabolic process (GO:0006013)3.07166695
64regulation of glucose import in response to insulin stimulus (GO:2001273)3.06834185
65pentose-phosphate shunt (GO:0006098)3.04435672
66regulation of mammary gland epithelial cell proliferation (GO:0033599)3.03866119
67IMP biosynthetic process (GO:0006188)3.02082577
68intracellular estrogen receptor signaling pathway (GO:0030520)3.01915857
69retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.00654452
70cellular protein complex localization (GO:0034629)3.00059713
71adherens junction assembly (GO:0034333)3.00004441
72cell-substrate adherens junction assembly (GO:0007045)2.99138053
73focal adhesion assembly (GO:0048041)2.99138053
74epithelial cell differentiation involved in prostate gland development (GO:0060742)2.96598701
75DNA replication-dependent nucleosome organization (GO:0034723)2.96314141
76DNA replication-dependent nucleosome assembly (GO:0006335)2.96314141
77nucleosome disassembly (GO:0006337)2.94491264
78protein-DNA complex disassembly (GO:0032986)2.94491264
79histone H3-K36 demethylation (GO:0070544)2.92704878
80modulation by symbiont of host cellular process (GO:0044068)2.88656328
81glucose 6-phosphate metabolic process (GO:0051156)2.88342134
82DNA topological change (GO:0006265)2.88204853
83G1 DNA damage checkpoint (GO:0044783)2.88147758
84regulation of DNA damage checkpoint (GO:2000001)2.84985140
85regulation of spindle organization (GO:0090224)2.82085466
86activation of Rac GTPase activity (GO:0032863)2.81533432
87regulation of NFAT protein import into nucleus (GO:0051532)2.81123715
88protein complex localization (GO:0031503)2.79823059
89histone H4-K5 acetylation (GO:0043981)2.78903426
90histone H4-K8 acetylation (GO:0043982)2.78903426
91cellular response to epidermal growth factor stimulus (GO:0071364)2.78271308
92mitotic G1/S transition checkpoint (GO:0044819)2.78110889
93modulation by virus of host process (GO:0019054)2.77833703
94mitotic metaphase plate congression (GO:0007080)2.77196526
95positive regulation of gamma-delta T cell activation (GO:0046645)2.76075633
96protein localization to chromosome (GO:0034502)2.75921166
97alternative mRNA splicing, via spliceosome (GO:0000380)2.75088784
98maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.72991812
99chromatin silencing (GO:0006342)2.72520541
100response to epidermal growth factor (GO:0070849)2.72266775
101mRNA transport (GO:0051028)2.71362626
102positive regulation of gene expression, epigenetic (GO:0045815)2.71267408
103regulation of mitotic spindle organization (GO:0060236)2.71013041
104protein retention in ER lumen (GO:0006621)2.70803207
105maternal placenta development (GO:0001893)2.70301399
106spindle assembly involved in mitosis (GO:0090307)2.70284894
107histone H4-K16 acetylation (GO:0043984)2.70155019
108DNA conformation change (GO:0071103)2.66537646
109corticosteroid receptor signaling pathway (GO:0031958)2.65964405
110regulation of mRNA stability (GO:0043488)2.65928356
111activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.65652240
112negative regulation of gene expression, epigenetic (GO:0045814)2.65300622
113cellular hyperosmotic response (GO:0071474)2.64969035
114histone arginine methylation (GO:0034969)2.64898795
115negative regulation of histone modification (GO:0031057)2.64769992
116negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.64629191
117gene silencing (GO:0016458)2.64290998
118positive regulation of nuclease activity (GO:0032075)2.63741050
119positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.63730146
120regulation of chromatin binding (GO:0035561)2.61401623
121establishment of apical/basal cell polarity (GO:0035089)2.60575763
122hippo signaling (GO:0035329)2.60466474
123NADPH regeneration (GO:0006740)2.59268069
124positive regulation of SMAD protein import into nucleus (GO:0060391)2.59059561
125DNA replication initiation (GO:0006270)2.58839974
126translesion synthesis (GO:0019985)2.57549111
127trophectodermal cell differentiation (GO:0001829)2.56900146
128positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.56639143
129positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.56639143
130positive regulation of mitotic sister chromatid separation (GO:1901970)2.56639143
131protoporphyrinogen IX metabolic process (GO:0046501)2.56495021
132microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.55351472
133negative regulation of myotube differentiation (GO:0010832)2.55240389
134negative regulation of cell size (GO:0045792)2.55001666
135nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.54137831
136gene silencing by RNA (GO:0031047)2.54094230
137regulation of chromosome segregation (GO:0051983)2.53423259
138histone H4-K12 acetylation (GO:0043983)2.53206699
139cellular response to virus (GO:0098586)2.51901626
140glucose catabolic process (GO:0006007)2.51883989
141cytoskeletal anchoring at plasma membrane (GO:0007016)2.51425428
142nucleic acid transport (GO:0050657)2.51150634
143RNA transport (GO:0050658)2.51150634
144establishment of RNA localization (GO:0051236)2.51150634
145negative regulation of striated muscle cell differentiation (GO:0051154)2.48964628
146proline metabolic process (GO:0006560)2.48350373
147response to laminar fluid shear stress (GO:0034616)2.47973010
148chromosome condensation (GO:0030261)2.46279101
149histone H4 deacetylation (GO:0070933)2.46158934
150regulation of type I interferon-mediated signaling pathway (GO:0060338)2.45682045
151planar cell polarity pathway involved in neural tube closure (GO:0090179)2.44920552
152pinocytosis (GO:0006907)2.43764278
153DNA strand elongation involved in DNA replication (GO:0006271)2.42713370
154regulation of nuclease activity (GO:0032069)2.42053577
155response to muramyl dipeptide (GO:0032495)2.40845244
156positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.40492302
157DNA strand elongation (GO:0022616)2.39347769
158positive regulation of Cdc42 GTPase activity (GO:0043089)2.38844110
159formation of translation preinitiation complex (GO:0001731)2.37300153
160peptidyl-threonine modification (GO:0018210)2.36602274
161cell-substrate junction assembly (GO:0007044)2.35945099
162peptidyl-threonine phosphorylation (GO:0018107)2.35761385
163endoplasmic reticulum unfolded protein response (GO:0030968)2.34812477
164stress fiber assembly (GO:0043149)2.33566918
165regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.32393225

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.19396843
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.42373756
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.76700619
4MYC_22102868_ChIP-Seq_BL_Human3.74807793
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.94168473
6* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.84552572
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.44551482
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.42901767
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.40841285
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37978625
11* MYC_18555785_ChIP-Seq_MESCs_Mouse2.36957402
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.29564338
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18777084
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.14615877
15KDM2B_26808549_Chip-Seq_DND41_Human2.12571784
16ZFP281_18757296_ChIP-ChIP_E14_Mouse2.08893604
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.05572817
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.04816814
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.98016993
20KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.96563275
21TCF7_22412390_ChIP-Seq_EML_Mouse1.95546156
22VDR_21846776_ChIP-Seq_THP-1_Human1.95181285
23* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.94929305
24* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.93029249
25SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.92062883
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.91887611
27CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.85321855
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.82049233
29ZNF263_19887448_ChIP-Seq_K562_Human1.78803223
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72944473
31SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.72740045
32AR_21909140_ChIP-Seq_LNCAP_Human1.70699885
33CIITA_25753668_ChIP-Seq_RAJI_Human1.65751881
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64810956
35ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.62989131
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.61619751
37CLOCK_20551151_ChIP-Seq_293T_Human1.58522932
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56782380
39DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.51827210
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.50943084
41XRN2_22483619_ChIP-Seq_HELA_Human1.50449931
42TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49781696
43* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.49719727
44NANOG_21062744_ChIP-ChIP_HESCs_Human1.49332510
45* KDM2B_26808549_Chip-Seq_JURKAT_Human1.49241025
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48383787
47KDM5A_27292631_Chip-Seq_BREAST_Human1.48194715
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.45174138
49VDR_24763502_ChIP-Seq_THP-1_Human1.44828959
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41326221
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40174984
52P300_27058665_Chip-Seq_ZR-75-30cells_Human1.39485797
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.38663113
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37543341
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36902993
56* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36897978
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35503219
58CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.35292702
59* KDM2B_26808549_Chip-Seq_K562_Human1.32624464
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31195765
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30974265
62* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29891638
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29633587
64MAF_26560356_Chip-Seq_TH2_Human1.29069108
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28058370
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.27088247
67CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26760628
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26242650
69PKCTHETA_26484144_Chip-Seq_BREAST_Human1.26006386
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.25049333
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24988266
72UTX_26944678_Chip-Seq_JUKART_Human1.24058852
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22622407
74NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.22267926
75CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21462778
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20964029
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20564609
78GATA1_19941826_ChIP-Seq_K562_Human1.20493173
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20064233
80RACK7_27058665_Chip-Seq_MCF-7_Human1.19901545
81MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19704827
82CHD1_26751641_Chip-Seq_LNCaP_Human1.19169966
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18005879
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17400859
85NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.17335924
86* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16276218
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16276138
88ATF3_27146783_Chip-Seq_COLON_Human1.16105495
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.14579228
90* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.14182825
91SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13831181
92CREB1_26743006_Chip-Seq_LNCaP_Human1.13823123
93* NCOR1_26117541_ChIP-Seq_K562_Human1.13510474
94TCF3_18692474_ChIP-Seq_MEFs_Mouse1.13134452
95* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.12296766
96MAF_26560356_Chip-Seq_TH1_Human1.12264684
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12125602
98* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11256239
99NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11037207
100POU5F1_16518401_ChIP-PET_MESCs_Mouse1.10609185
101ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09812399
102ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09103874
103TET1_21451524_ChIP-Seq_MESCs_Mouse1.08307001
104LXR_22292898_ChIP-Seq_THP-1_Human1.07741317
105TCF3_18692474_ChIP-Seq_MESCs_Mouse1.07017261
106GATA1_19941827_ChIP-Seq_MEL_Mouse1.06948090
107MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06575419
108TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04979551
109FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04389942
110* SMC4_20622854_ChIP-Seq_HELA_Human1.03957732
111* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03145657
112SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03017439
113SCL_19346495_ChIP-Seq_HPC-7_Human1.02680912
114* SPI1_23127762_ChIP-Seq_K562_Human1.01330525
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00914576
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00867519
117STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00669378
118KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00623915
119KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00623915
120KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00623915
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00460062
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98875330
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98556391
124TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97369709
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96676386
126SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96572318
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96518306
128TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95645142
129RARB_27405468_Chip-Seq_BRAIN_Mouse0.93109341
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93011824
131P68_20966046_ChIP-Seq_HELA_Human0.92956232
132TP53_22127205_ChIP-Seq_IMR90_Human0.92340056
133* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92316563
134RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87060184

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.88989778
2MP0003111_abnormal_nucleus_morphology3.64004987
3MP0005076_abnormal_cell_differentiation3.44711991
4MP0010352_gastrointestinal_tract_polyps3.29915077
5MP0003705_abnormal_hypodermis_morpholog3.28596382
6MP0010094_abnormal_chromosome_stability3.09603779
7MP0004957_abnormal_blastocyst_morpholog2.83372958
8MP0003693_abnormal_embryo_hatching2.69079927
9MP0008057_abnormal_DNA_replication2.67062128
10MP0003077_abnormal_cell_cycle2.62759296
11MP0000537_abnormal_urethra_morphology2.62345787
12MP0003123_paternal_imprinting2.59460794
13* MP0001730_embryonic_growth_arrest2.36330470
14MP0008260_abnormal_autophagy2.26636802
15MP0000350_abnormal_cell_proliferation2.26199447
16MP0010307_abnormal_tumor_latency2.19480979
17MP0005058_abnormal_lysosome_morphology2.13536303
18MP0009278_abnormal_bone_marrow2.13150466
19MP0004197_abnormal_fetal_growth/weight/2.13087646
20* MP0002084_abnormal_developmental_patter2.08896096
21MP0000569_abnormal_digit_pigmentation2.03827496
22MP0010234_abnormal_vibrissa_follicle1.97069535
23* MP0005380_embryogenesis_phenotype1.96487406
24* MP0001672_abnormal_embryogenesis/_devel1.96487406
25MP0008007_abnormal_cellular_replicative1.94683248
26MP0010030_abnormal_orbit_morphology1.89837935
27* MP0002085_abnormal_embryonic_tissue1.87395430
28* MP0002086_abnormal_extraembryonic_tissu1.85331287
29* MP0001697_abnormal_embryo_size1.81557752
30* MP0003984_embryonic_growth_retardation1.80729296
31MP0000678_abnormal_parathyroid_gland1.80414241
32* MP0002088_abnormal_embryonic_growth/wei1.77951593
33MP0003119_abnormal_digestive_system1.73856824
34MP0001849_ear_inflammation1.73473157
35MP0003453_abnormal_keratinocyte_physiol1.73360352
36MP0004233_abnormal_muscle_weight1.73156172
37MP0002396_abnormal_hematopoietic_system1.71296964
38MP0004859_abnormal_synaptic_plasticity1.70269287
39MP0003172_abnormal_lysosome_physiology1.69770278
40MP0003283_abnormal_digestive_organ1.69127503
41MP0003121_genomic_imprinting1.67954801
42* MP0002080_prenatal_lethality1.66340363
43MP0008961_abnormal_basal_metabolism1.63566200
44MP0002653_abnormal_ependyma_morphology1.62815048
45MP0003436_decreased_susceptibility_to1.61163816
46MP0003656_abnormal_erythrocyte_physiolo1.58031328
47MP0005409_darkened_coat_color1.57946666
48MP0004947_skin_inflammation1.57308986
49MP0000858_altered_metastatic_potential1.56294980
50MP0003303_peritoneal_inflammation1.55549403
51MP0009672_abnormal_birth_weight1.49431056
52MP0009703_decreased_birth_body1.49046702
53MP0005666_abnormal_adipose_tissue1.45981080
54MP0008058_abnormal_DNA_repair1.44557998
55MP0009840_abnormal_foam_cell1.43578051
56MP0003763_abnormal_thymus_physiology1.43426634
57MP0000733_abnormal_muscle_development1.43222336
58MP0009053_abnormal_anal_canal1.41982766
59MP0008932_abnormal_embryonic_tissue1.35290376
60MP0004808_abnormal_hematopoietic_stem1.34888966
61MP0003567_abnormal_fetal_cardiomyocyte1.34320040
62MP0000428_abnormal_craniofacial_morphol1.31756326
63MP0008438_abnormal_cutaneous_collagen1.26132644
64* MP0003861_abnormal_nervous_system1.24896303
65MP0001348_abnormal_lacrimal_gland1.24369243
66MP0003566_abnormal_cell_adhesion1.24339596
67MP0008770_decreased_survivor_rate1.23541846
68MP0003115_abnormal_respiratory_system1.23302459
69MP0009333_abnormal_splenocyte_physiolog1.23253249
70MP0003787_abnormal_imprinting1.21280338
71MP0002877_abnormal_melanocyte_morpholog1.21214870
72MP0003221_abnormal_cardiomyocyte_apopto1.16713522
73MP0003329_amyloid_beta_deposits1.16182352
74MP0002398_abnormal_bone_marrow1.15759674
75MP0003191_abnormal_cellular_cholesterol1.14962620
76MP0005187_abnormal_penis_morphology1.14073300
77MP0004185_abnormal_adipocyte_glucose1.12870700
78MP0002009_preneoplasia1.05535116
79MP0001293_anophthalmia1.05321333
80* MP0003890_abnormal_embryonic-extraembry1.05309749
81MP0000490_abnormal_crypts_of1.03907322
82MP0005397_hematopoietic_system_phenotyp1.03855141
83MP0001545_abnormal_hematopoietic_system1.03855141
84MP0000681_abnormal_thyroid_gland1.02885974
85MP0003300_gastrointestinal_ulcer1.01903159
86MP0000313_abnormal_cell_death1.01658482
87MP0000703_abnormal_thymus_morphology1.01036839
88MP0005367_renal/urinary_system_phenotyp1.01034456
89MP0000516_abnormal_urinary_system1.01034456
90MP0005623_abnormal_meninges_morphology1.00260127
91MP0004133_heterotaxia1.00101551
92MP0002722_abnormal_immune_system0.99675554
93MP0005375_adipose_tissue_phenotype0.99475436
94MP0010630_abnormal_cardiac_muscle0.98007994
95MP0004858_abnormal_nervous_system0.96671676
96MP0002796_impaired_skin_barrier0.96179473
97* MP0002925_abnormal_cardiovascular_devel0.96025296
98MP0000747_muscle_weakness0.95322756
99MP0002019_abnormal_tumor_incidence0.94656134
100MP0004264_abnormal_extraembryonic_tissu0.94385466
101MP0005501_abnormal_skin_physiology0.94000674
102MP0002092_abnormal_eye_morphology0.92895843
103* MP0003935_abnormal_craniofacial_develop0.92258166
104MP0005464_abnormal_platelet_physiology0.91591689
105MP0008877_abnormal_DNA_methylation0.90337357
106MP0009931_abnormal_skin_appearance0.89687149
107MP0002249_abnormal_larynx_morphology0.89570205
108MP0005394_taste/olfaction_phenotype0.89058486
109MP0005499_abnormal_olfactory_system0.89058486
110MP0002111_abnormal_tail_morphology0.88254216
111MP0002429_abnormal_blood_cell0.87801541
112MP0005621_abnormal_cell_physiology0.86559823
113MP0005257_abnormal_intraocular_pressure0.86554690
114MP0002697_abnormal_eye_size0.86009182
115MP0001915_intracranial_hemorrhage0.84207410
116MP0004811_abnormal_neuron_physiology0.84099591
117MP0002089_abnormal_postnatal_growth/wei0.83310619
118MP0002060_abnormal_skin_morphology0.81263461
119MP0000685_abnormal_immune_system0.81138879
120MP0005384_cellular_phenotype0.80534609
121MP0005023_abnormal_wound_healing0.79922438
122MP0000534_abnormal_ureter_morphology0.78658852
123MP0002081_perinatal_lethality0.77364722
124MP0002419_abnormal_innate_immunity0.76754696
125MP0005025_abnormal_response_to0.76402503
126MP0001661_extended_life_span0.74268026
127* MP0000432_abnormal_head_morphology0.74159328
128MP0004381_abnormal_hair_follicle0.73732788
129MP0003937_abnormal_limbs/digits/tail_de0.73508798
130MP0000716_abnormal_immune_system0.73244972
131MP0003385_abnormal_body_wall0.72621477
132* MP0000266_abnormal_heart_morphology0.72497099
133MP0002932_abnormal_joint_morphology0.72094535
134MP0002114_abnormal_axial_skeleton0.71441615
135* MP0002152_abnormal_brain_morphology0.71345806
136MP0000609_abnormal_liver_physiology0.71113878
137MP0001216_abnormal_epidermal_layer0.69839887
138MP0000689_abnormal_spleen_morphology0.68483090
139* MP0001784_abnormal_fluid_regulation0.68398459
140MP0004885_abnormal_endolymph0.67771725
141MP0003786_premature_aging0.67736182
142MP0006054_spinal_hemorrhage0.66243953
143MP0002116_abnormal_craniofacial_bone0.65292580
144MP0003091_abnormal_cell_migration0.65192703
145MP0000003_abnormal_adipose_tissue0.65157689

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)4.32059647
2Ependymoma (HP:0002888)3.66615926
3Abnormality of the astrocytes (HP:0100707)3.51296501
4Astrocytoma (HP:0009592)3.51296501
5Abnormal gallbladder physiology (HP:0012438)3.06807405
6Cholecystitis (HP:0001082)3.06807405
7Reticulocytosis (HP:0001923)2.96154529
8Renal duplication (HP:0000075)2.89556018
9Abnormality of the lower motor neuron (HP:0002366)2.87219665
10Increased nuchal translucency (HP:0010880)2.85515642
11Disproportionate tall stature (HP:0001519)2.83448724
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.81367747
13Short 4th metacarpal (HP:0010044)2.81367747
14Insomnia (HP:0100785)2.70385102
15Pointed chin (HP:0000307)2.67883690
16Elfin facies (HP:0004428)2.66164047
17Glioma (HP:0009733)2.59957726
18Volvulus (HP:0002580)2.56995275
19Renovascular hypertension (HP:0100817)2.56396639
20Medulloblastoma (HP:0002885)2.55897523
21Heterotopia (HP:0002282)2.47878030
22Overriding aorta (HP:0002623)2.45780010
23Colon cancer (HP:0003003)2.35801057
24Neoplasm of the oral cavity (HP:0100649)2.35210156
25Abnormality of the labia minora (HP:0012880)2.34398940
26Long palpebral fissure (HP:0000637)2.34101310
27Broad palm (HP:0001169)2.31967614
28Facial hemangioma (HP:0000329)2.30815963
29Asymmetry of the thorax (HP:0001555)2.28204211
30Polycythemia (HP:0001901)2.27054593
31Achilles tendon contracture (HP:0001771)2.23674725
32Subacute progressive viral hepatitis (HP:0006572)2.22955554
33Shallow orbits (HP:0000586)2.22436744
34Basal cell carcinoma (HP:0002671)2.22256833
35Abnormality of the fingertips (HP:0001211)2.20140031
36Gastrointestinal carcinoma (HP:0002672)2.19818957
37Malignant gastrointestinal tract tumors (HP:0006749)2.19818957
38Deep palmar crease (HP:0006191)2.19041863
39Abnormality of the 4th metacarpal (HP:0010012)2.18483296
40* Bowel incontinence (HP:0002607)2.17577248
41Abnormality of reticulocytes (HP:0004312)2.16956373
42Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.16518525
43Centrally nucleated skeletal muscle fibers (HP:0003687)2.16287581
44Cerebral aneurysm (HP:0004944)2.16085310
45Increased connective tissue (HP:0009025)2.14184579
46Protrusio acetabuli (HP:0003179)2.13914682
47Annular pancreas (HP:0001734)2.13111101
48Cellulitis (HP:0100658)2.10881657
49Abnormality of the diencephalon (HP:0010662)2.09617249
50Macroorchidism (HP:0000053)2.09337645
51Pelvic girdle muscle weakness (HP:0003749)2.08987179
52Obstructive sleep apnea (HP:0002870)2.07787760
53Deviation of the thumb (HP:0009603)2.06376899
54Proximal placement of thumb (HP:0009623)2.05614435
55* Abnormal large intestine physiology (HP:0012700)2.05582576
56Selective tooth agenesis (HP:0001592)2.04982978
57Bowel diverticulosis (HP:0005222)2.04925342
58Distal lower limb amyotrophy (HP:0008944)2.04911182
59Broad face (HP:0000283)2.04555235
60Overlapping toe (HP:0001845)2.04539651
61Fibroma (HP:0010614)2.04146807
62Neoplasm of striated muscle (HP:0009728)2.03955264
63Abnormality of the Achilles tendon (HP:0005109)2.03425981
64Eczematoid dermatitis (HP:0000976)2.02301204
65Long eyelashes (HP:0000527)2.01851943
66Fibrous tissue neoplasm (HP:0012316)2.01339085
67Metaphyseal cupping (HP:0003021)2.00759694
68Amyotrophic lateral sclerosis (HP:0007354)2.00414500
69Peripheral hypomyelination (HP:0007182)2.00187839
70Hemorrhage of the eye (HP:0011885)1.99546985
71Pseudobulbar signs (HP:0002200)1.99273965
72Segmental peripheral demyelination/remyelination (HP:0003481)1.98949920
73Abnormality of the thoracic spine (HP:0100711)1.97788951
74Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.96749586
75Abnormality of chromosome segregation (HP:0002916)1.96248743
76Flat acetabular roof (HP:0003180)1.96113105
77Shoulder girdle muscle weakness (HP:0003547)1.91854707
78Rhabdomyosarcoma (HP:0002859)1.90971428
79Prominent nose (HP:0000448)1.90552719
80Deep venous thrombosis (HP:0002625)1.89702711
81Obsessive-compulsive behavior (HP:0000722)1.88244520
82Ankyloglossia (HP:0010296)1.86790193
83Ulnar bowing (HP:0003031)1.86232250
84Vertebral arch anomaly (HP:0008438)1.85158768
85Slow saccadic eye movements (HP:0000514)1.84582327
86Spinal cord lesions (HP:0100561)1.83918220
87Syringomyelia (HP:0003396)1.83918220
88Sacral dimple (HP:0000960)1.83424775
89Rib fusion (HP:0000902)1.82979143
90Broad thumb (HP:0011304)1.82891107
91Genu recurvatum (HP:0002816)1.81666886
92* Truncus arteriosus (HP:0001660)1.81497225
93Urethral obstruction (HP:0000796)1.81067901
94Leiomyosarcoma (HP:0100243)1.81030365
95Uterine leiomyosarcoma (HP:0002891)1.81030365
96Enlarged penis (HP:0000040)1.80582731
97Cerebral inclusion bodies (HP:0100314)1.80322795
98Cholelithiasis (HP:0001081)1.80120187
99Skin tags (HP:0010609)1.79841912
100Flat cornea (HP:0007720)1.79411231
101Back pain (HP:0003418)1.79343472
102Upper limb amyotrophy (HP:0009129)1.78840906
103Distal upper limb amyotrophy (HP:0007149)1.78840906
104Abnormality of the calcaneus (HP:0008364)1.78605776
105Hand muscle atrophy (HP:0009130)1.78007576
106Premature rupture of membranes (HP:0001788)1.77664330
107Increased density of long bones (HP:0006392)1.77409797
108Thin bony cortex (HP:0002753)1.75850618
109Arnold-Chiari malformation (HP:0002308)1.75827794
110Dysmetric saccades (HP:0000641)1.75662604
111Spinal muscular atrophy (HP:0007269)1.75513278
112Insidious onset (HP:0003587)1.75139060
113Termporal pattern (HP:0011008)1.75139060
114Vertebral compression fractures (HP:0002953)1.75012154
115Progressive external ophthalmoplegia (HP:0000590)1.74450127
116Spina bifida occulta (HP:0003298)1.74224739
117Thin ribs (HP:0000883)1.73912280
118Broad alveolar ridges (HP:0000187)1.73815622
119Patellar aplasia (HP:0006443)1.73717695
120Resting tremor (HP:0002322)1.73585519
121Megalocornea (HP:0000485)1.72931650
122Abnormal number of incisors (HP:0011064)1.72650474
123Dilatation of the ascending aorta (HP:0005111)1.72545707
124Cutis marmorata (HP:0000965)1.72193171
125Orthostatic hypotension (HP:0001278)1.72052571
126Atrophy/Degeneration involving motor neurons (HP:0007373)1.71849294
127Decreased motor nerve conduction velocity (HP:0003431)1.71735829
128Cafe-au-lait spot (HP:0000957)1.71572154
129Premature skin wrinkling (HP:0100678)1.71478398
130Sandal gap (HP:0001852)1.71054151
131Persistence of primary teeth (HP:0006335)1.70101623
132Biconcave vertebral bodies (HP:0004586)1.69012883
133Trigonocephaly (HP:0000243)1.68746331
134Progressive muscle weakness (HP:0003323)1.68536584
135Relative macrocephaly (HP:0004482)1.68186042
136Hammertoe (HP:0001765)1.67688595
137High pitched voice (HP:0001620)1.66210102
138Abnormality of the musculature of the pelvis (HP:0001469)1.65838760
139Abnormality of the hip-girdle musculature (HP:0001445)1.65838760
140Rectal prolapse (HP:0002035)1.65440397
141Polygenic inheritance (HP:0010982)1.64646410
142Transitional cell carcinoma of the bladder (HP:0006740)1.64396521
143Thoracic kyphosis (HP:0002942)1.64115684
144Angiofibromas (HP:0010615)1.63193770
145Adenoma sebaceum (HP:0009720)1.63193770
146Aplasia/Hypoplasia of the patella (HP:0006498)1.63078175
147Supernumerary ribs (HP:0005815)1.62953075
148Abnormality of oral frenula (HP:0000190)1.62692604
149Cortical dysplasia (HP:0002539)1.62369367
150Myocardial infarction (HP:0001658)1.61753220
151Missing ribs (HP:0000921)1.61368091
152Hyperparathyroidism (HP:0000843)1.60964935
153Short phalanx of the thumb (HP:0009660)1.59836580
154Intestinal polyp (HP:0005266)1.59281968
155Neoplasm of the heart (HP:0100544)1.58301017
156Hallux valgus (HP:0001822)1.58195265
157Bladder carcinoma (HP:0002862)1.57773545
158Lower limb amyotrophy (HP:0007210)1.56721157
159Aneurysm (HP:0002617)1.56640076
160Fatigue (HP:0012378)1.54143601
161Nonimmune hydrops fetalis (HP:0001790)1.53888974
162* Patellar dislocation (HP:0002999)1.53857440
163Abnormality of the distal phalanx of the thumb (HP:0009617)1.53360150
164Sparse lateral eyebrow (HP:0005338)1.52465103
165Germ cell neoplasia (HP:0100728)1.52092210
166Colitis (HP:0002583)1.52039283
167Mitral regurgitation (HP:0001653)1.50839035
168Dislocated radial head (HP:0003083)1.50428114
169Abnormality of the gallbladder (HP:0005264)1.50307689
170Increased variability in muscle fiber diameter (HP:0003557)1.49969440
171Mitral valve prolapse (HP:0001634)1.49612362
172Increased IgE level (HP:0003212)1.46689389

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.94165419
2TRIB33.66976120
3PRPF4B3.66318908
4SMG13.53153101
5MAP3K103.45793801
6CDK123.35650050
7PKN23.10954037
8ICK2.54310008
9CDC72.49441887
10IRAK32.46477811
11ALK2.41778741
12NEK22.36456416
13SIK12.33748151
14FGFR42.21274372
15ERN12.08594222
16NEK11.98352637
17RIPK41.92098206
18SCYL21.80380937
19LATS21.79484754
20TYRO31.69563082
21MAP3K91.65143404
22PDGFRA1.63907966
23MAP3K131.50686928
24SIK21.47544985
25PTK61.45008692
26MAP2K31.44463317
27MTOR1.42112040
28LATS11.41127439
29RPS6KB21.35354546
30PRKD31.34966600
31CDK41.31282470
32TSSK61.30787130
33BMX1.25525354
34TAOK11.25498718
35PAK41.25331568
36CDK61.25297262
37RIPK11.25007283
38TTK1.22965774
39TAOK21.21296637
40BRD41.19696297
41KSR11.18495146
42GRK61.17288327
43PASK1.15135144
44CHEK11.14944341
45MARK21.13770814
46MAP3K81.12425673
47KSR21.08771750
48MAP3K11.08639181
49WEE11.04391615
50PAK61.04029906
51STK31.02206686
52DDR21.01989795
53CLK11.01360825
54MARK10.99848059
55TTN0.99205433
56TESK20.98661789
57IRAK40.98585305
58CAMKK10.98477459
59RAF10.95075000
60STK100.94969489
61ATR0.94780558
62CDK70.92786218
63NME20.92351240
64* CDK20.91480454
65BRAF0.89044022
66EPHB10.87063041
67FGFR30.84586893
68LRRK20.83992603
69IRAK20.83657365
70PLK10.83376776
71BRSK10.83046873
72BUB10.82172492
73PAK20.81479381
74MAP3K140.80849654
75FGFR10.79564622
76CHEK20.77807351
77TYK20.77231206
78MAPK110.75372971
79ARAF0.74631258
80UHMK10.71486009
81EPHA20.70800663
82PDPK10.70435463
83PLK30.69257237
84RET0.68378354
85AURKB0.67610326
86NTRK10.66495806
87ATM0.65638806
88CSNK1D0.65377105
89CSNK1E0.65350668
90CDK10.63388935
91PDGFRB0.63106084
92DAPK10.61791695
93MAP3K110.61228158
94PNCK0.59122795
95HIPK20.58577682
96CAMK1G0.58404974
97MAP3K30.58387354
98AKT20.55791858
99MAP2K20.54753570
100PRKCH0.52602091
101SIK30.52581180
102NTRK30.52177890
103RPS6KA10.52031533
104EIF2AK10.51837112
105JAK30.51642264
106ZAP700.50957247
107DAPK20.50811384
108RPS6KA20.50400925
109PRKDC0.50116074
110MINK10.50025391
111MAPK140.49158918
112MAP3K60.48943762
113RPS6KL10.48931688
114RPS6KC10.48931688
115JAK20.48806864
116PTK20.47240353
117STK40.45910399
118CDK150.45507985
119CDC42BPA0.44707321
120BTK0.44636973
121STK380.44584204
122PRKD20.44370662
123MKNK10.44342498
124CAMK1D0.43862066
125GSK3B0.43096816
126CDK11A0.42731162
127RPS6KA40.42348913
128PDK10.42345258
129STK110.42114783
130MAPK100.41661232
131CSK0.41005142
132MOS0.40896902
133MAP3K20.40645068
134CDK180.40333119
135WNK10.39728511
136SGK30.39642015
137NTRK20.39138030
138PIM10.38518738
139MAP3K40.37888233
140MAPK80.37454654
141TGFBR10.37398698
142MAP3K70.37074668
143AURKA0.37014241
144MAP4K10.36606088
145HCK0.34753521
146DMPK0.34413436

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.22122563
2RNA transport_Homo sapiens_hsa030132.23389815
3mRNA surveillance pathway_Homo sapiens_hsa030152.19917779
4DNA replication_Homo sapiens_hsa030302.11454457
5mTOR signaling pathway_Homo sapiens_hsa041501.97804164
6Spliceosome_Homo sapiens_hsa030401.89568373
7Cell cycle_Homo sapiens_hsa041101.88905493
8Other glycan degradation_Homo sapiens_hsa005111.83353538
9Mismatch repair_Homo sapiens_hsa034301.79247843
10Chronic myeloid leukemia_Homo sapiens_hsa052201.72889748
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72844792
12Endometrial cancer_Homo sapiens_hsa052131.60817678
13Colorectal cancer_Homo sapiens_hsa052101.57546153
14One carbon pool by folate_Homo sapiens_hsa006701.57108685
15Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.54263670
16Glioma_Homo sapiens_hsa052141.49519884
17Prion diseases_Homo sapiens_hsa050201.48562832
18Oocyte meiosis_Homo sapiens_hsa041141.47345589
19MicroRNAs in cancer_Homo sapiens_hsa052061.46483672
20Non-small cell lung cancer_Homo sapiens_hsa052231.46265064
21Hippo signaling pathway_Homo sapiens_hsa043901.45103954
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44445100
23Pentose phosphate pathway_Homo sapiens_hsa000301.28268771
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26685414
25Notch signaling pathway_Homo sapiens_hsa043301.26111336
26Neurotrophin signaling pathway_Homo sapiens_hsa047221.25474431
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24924840
28Base excision repair_Homo sapiens_hsa034101.23943032
29Thyroid hormone signaling pathway_Homo sapiens_hsa049191.22626488
30Basal cell carcinoma_Homo sapiens_hsa052171.21559417
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.20840624
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20275639
33Estrogen signaling pathway_Homo sapiens_hsa049151.18173460
34Lysine degradation_Homo sapiens_hsa003101.14910480
35VEGF signaling pathway_Homo sapiens_hsa043701.13354197
36Dorso-ventral axis formation_Homo sapiens_hsa043201.11550990
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10868596
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10631229
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10429020
40Adherens junction_Homo sapiens_hsa045201.10007307
41Proteoglycans in cancer_Homo sapiens_hsa052051.09663429
42Small cell lung cancer_Homo sapiens_hsa052221.09063290
43HTLV-I infection_Homo sapiens_hsa051661.06716842
44ErbB signaling pathway_Homo sapiens_hsa040121.06658347
45Osteoclast differentiation_Homo sapiens_hsa043801.06242395
46Viral carcinogenesis_Homo sapiens_hsa052031.05747578
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04630961
48Bladder cancer_Homo sapiens_hsa052191.03849486
49Longevity regulating pathway - mammal_Homo sapiens_hsa042111.02949885
50Hepatitis C_Homo sapiens_hsa051601.02507325
51Thyroid cancer_Homo sapiens_hsa052161.02320182
52Hedgehog signaling pathway_Homo sapiens_hsa043400.99539777
53Nucleotide excision repair_Homo sapiens_hsa034200.98129836
54Acute myeloid leukemia_Homo sapiens_hsa052210.97575307
55Long-term potentiation_Homo sapiens_hsa047200.96200763
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95900404
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95245641
58Renal cell carcinoma_Homo sapiens_hsa052110.95211044
59p53 signaling pathway_Homo sapiens_hsa041150.95198048
60Pancreatic cancer_Homo sapiens_hsa052120.94731414
61Fructose and mannose metabolism_Homo sapiens_hsa000510.93615593
62B cell receptor signaling pathway_Homo sapiens_hsa046620.93565314
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93146499
64Type II diabetes mellitus_Homo sapiens_hsa049300.93031422
65Measles_Homo sapiens_hsa051620.91009272
66Influenza A_Homo sapiens_hsa051640.89528108
67Gap junction_Homo sapiens_hsa045400.89430587
68Fanconi anemia pathway_Homo sapiens_hsa034600.87095320
69Shigellosis_Homo sapiens_hsa051310.86080201
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85691780
71Insulin signaling pathway_Homo sapiens_hsa049100.81304919
72Wnt signaling pathway_Homo sapiens_hsa043100.80780551
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.80449934
74Inositol phosphate metabolism_Homo sapiens_hsa005620.80415003
75Prolactin signaling pathway_Homo sapiens_hsa049170.80211503
76Tight junction_Homo sapiens_hsa045300.78205049
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.78094490
78AMPK signaling pathway_Homo sapiens_hsa041520.76615717
79Prostate cancer_Homo sapiens_hsa052150.75239158
80FoxO signaling pathway_Homo sapiens_hsa040680.74729524
81Non-homologous end-joining_Homo sapiens_hsa034500.74458324
82Focal adhesion_Homo sapiens_hsa045100.73725840
83Galactose metabolism_Homo sapiens_hsa000520.73366625
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.73293685
85TNF signaling pathway_Homo sapiens_hsa046680.73200298
86HIF-1 signaling pathway_Homo sapiens_hsa040660.72639152
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71908676
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71805390
89Carbon metabolism_Homo sapiens_hsa012000.71659960
90GnRH signaling pathway_Homo sapiens_hsa049120.71637817
91Leishmaniasis_Homo sapiens_hsa051400.71184334
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70682002
93Herpes simplex infection_Homo sapiens_hsa051680.70502033
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.69768565
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68668567
96Biosynthesis of amino acids_Homo sapiens_hsa012300.68483002
97TGF-beta signaling pathway_Homo sapiens_hsa043500.68037082
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67980593
99Choline metabolism in cancer_Homo sapiens_hsa052310.67712744
100Viral myocarditis_Homo sapiens_hsa054160.67552104
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67467235
102Toxoplasmosis_Homo sapiens_hsa051450.67002455
103T cell receptor signaling pathway_Homo sapiens_hsa046600.66721563
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66042917
105Homologous recombination_Homo sapiens_hsa034400.65125550
106Pathways in cancer_Homo sapiens_hsa052000.65108656
107Rap1 signaling pathway_Homo sapiens_hsa040150.64916408
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.64101300
109Hepatitis B_Homo sapiens_hsa051610.63632175
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63474722
111Epstein-Barr virus infection_Homo sapiens_hsa051690.63256714
112RNA degradation_Homo sapiens_hsa030180.62971667
113Insulin resistance_Homo sapiens_hsa049310.62109164
114MAPK signaling pathway_Homo sapiens_hsa040100.61915401
115Dopaminergic synapse_Homo sapiens_hsa047280.61347369
116Amoebiasis_Homo sapiens_hsa051460.60888344
117Melanogenesis_Homo sapiens_hsa049160.60879804
118Nitrogen metabolism_Homo sapiens_hsa009100.60497968
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60385185
120Salmonella infection_Homo sapiens_hsa051320.56085503
121Chemokine signaling pathway_Homo sapiens_hsa040620.55138505
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54948741
123Axon guidance_Homo sapiens_hsa043600.54903782
124Endocytosis_Homo sapiens_hsa041440.54420065
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54307345
126Glucagon signaling pathway_Homo sapiens_hsa049220.54018908
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53382391
128Thyroid hormone synthesis_Homo sapiens_hsa049180.52304368
129Oxytocin signaling pathway_Homo sapiens_hsa049210.52114916
130Alcoholism_Homo sapiens_hsa050340.52050893
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51994300
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.51748001
1332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51551659
134Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51407545
135Apoptosis_Homo sapiens_hsa042100.51391708
136Tuberculosis_Homo sapiens_hsa051520.48002506
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47755974
138Melanoma_Homo sapiens_hsa052180.44975654

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