HIRIP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.36818391
2mitotic sister chromatid segregation (GO:0000070)5.19814472
3mitotic chromosome condensation (GO:0007076)5.01161742
4mitotic metaphase plate congression (GO:0007080)4.99176121
5protein localization to chromosome, centromeric region (GO:0071459)4.93453594
6sister chromatid segregation (GO:0000819)4.76781486
7DNA unwinding involved in DNA replication (GO:0006268)4.60290861
8DNA replication checkpoint (GO:0000076)4.52319461
9deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.45678863
10mitotic sister chromatid cohesion (GO:0007064)4.44539902
11DNA replication-dependent nucleosome organization (GO:0034723)4.43089662
12DNA replication-dependent nucleosome assembly (GO:0006335)4.43089662
13metaphase plate congression (GO:0051310)4.35679947
14nuclear pore complex assembly (GO:0051292)4.25965787
15DNA replication initiation (GO:0006270)4.25250329
16regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.21623765
17regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.19432877
18nuclear pore organization (GO:0006999)4.18865458
19mitotic nuclear envelope disassembly (GO:0007077)4.18527637
20kinetochore organization (GO:0051383)4.17945737
21DNA topological change (GO:0006265)4.04821921
22attachment of spindle microtubules to kinetochore (GO:0008608)4.01237148
23DNA strand elongation involved in DNA replication (GO:0006271)3.99866849
24regulation of mitochondrial translation (GO:0070129)3.98592254
25establishment of chromosome localization (GO:0051303)3.94204755
26membrane disassembly (GO:0030397)3.88947024
27nuclear envelope disassembly (GO:0051081)3.88947024
28kinetochore assembly (GO:0051382)3.83704227
29DNA strand elongation (GO:0022616)3.79647618
30regulation of sister chromatid cohesion (GO:0007063)3.78795289
31pre-miRNA processing (GO:0031054)3.76342050
32meiotic chromosome segregation (GO:0045132)3.75807822
33heterochromatin organization (GO:0070828)3.74161757
34DNA ligation (GO:0006266)3.72424538
35establishment of integrated proviral latency (GO:0075713)3.71783095
36DNA replication-independent nucleosome assembly (GO:0006336)3.71633856
37DNA replication-independent nucleosome organization (GO:0034724)3.71633856
38chromatin remodeling at centromere (GO:0031055)3.71551876
39regulation of spindle organization (GO:0090224)3.68308738
40telomere maintenance via semi-conservative replication (GO:0032201)3.65377823
41* chromatin assembly or disassembly (GO:0006333)3.63926029
42CENP-A containing nucleosome assembly (GO:0034080)3.63168802
43chromosome segregation (GO:0007059)3.61637634
44protein localization to chromosome (GO:0034502)3.61116945
45positive regulation of chromosome segregation (GO:0051984)3.60247880
46negative regulation of histone methylation (GO:0031061)3.59593625
47ribosomal small subunit biogenesis (GO:0042274)3.57119611
48chromatin assembly (GO:0031497)3.53945043
49histone exchange (GO:0043486)3.49156744
50folic acid-containing compound biosynthetic process (GO:0009396)3.46975895
51negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.46144378
52DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.44130485
53DNA duplex unwinding (GO:0032508)3.42750483
54maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.42543998
55DNA geometric change (GO:0032392)3.41195246
56regulation of chromosome segregation (GO:0051983)3.40022230
57telomere maintenance via recombination (GO:0000722)3.39482059
58chromosome condensation (GO:0030261)3.38529340
59mitotic recombination (GO:0006312)3.38408200
60protein K6-linked ubiquitination (GO:0085020)3.35937542
61DNA damage response, signal transduction resulting in transcription (GO:0042772)3.34038567
62histone H2A monoubiquitination (GO:0035518)3.33551695
63deoxyribonucleotide biosynthetic process (GO:0009263)3.33537903
64base-excision repair (GO:0006284)3.33090249
65regulation of histone H3-K9 methylation (GO:0051570)3.32548708
66regulation of centrosome cycle (GO:0046605)3.31676407
67positive regulation of mitotic sister chromatid separation (GO:1901970)3.30191862
68positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.30191862
69positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.30191862
70regulation of mitotic spindle organization (GO:0060236)3.28414117
71transcription-coupled nucleotide-excision repair (GO:0006283)3.27770940
72mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.26320312
73regulation of centriole replication (GO:0046599)3.24979225
74spindle checkpoint (GO:0031577)3.19825001
75DNA conformation change (GO:0071103)3.18686379
76ATP-dependent chromatin remodeling (GO:0043044)3.17741688
77pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.17034618
782-deoxyribonucleotide biosynthetic process (GO:0009265)3.16361865
79deoxyribose phosphate biosynthetic process (GO:0046385)3.16361865
80DNA packaging (GO:0006323)3.15266929
81viral mRNA export from host cell nucleus (GO:0046784)3.13975352
82nucleotide-excision repair, DNA gap filling (GO:0006297)3.13878641
83telomere maintenance via telomere lengthening (GO:0010833)3.13869473
84oxidative phosphorylation (GO:0006119)3.13833402
85mRNA stabilization (GO:0048255)3.13355890
86RNA stabilization (GO:0043489)3.13355890
87negative regulation of chromosome segregation (GO:0051985)3.13088650
88pore complex assembly (GO:0046931)3.13071080
89regulation of RNA export from nucleus (GO:0046831)3.11315052
90pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.10523729
91regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.09955136
92L-serine metabolic process (GO:0006563)3.09855526
93negative regulation of mRNA processing (GO:0050686)3.08439541
94pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.08340143
95maturation of SSU-rRNA (GO:0030490)3.08198350
96negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.06143228
97negative regulation of RNA splicing (GO:0033119)3.05955212
98regulation of mitotic metaphase/anaphase transition (GO:0030071)3.05055138
99maturation of 5.8S rRNA (GO:0000460)3.04794036
100nuclear envelope organization (GO:0006998)3.03851264
101pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.02162662
102histone H2A acetylation (GO:0043968)3.01745606
103regulation of double-strand break repair via homologous recombination (GO:0010569)3.01711281
104spindle assembly checkpoint (GO:0071173)3.00221000
105negative regulation of mitotic sister chromatid separation (GO:2000816)2.99642869
106negative regulation of mitotic sister chromatid segregation (GO:0033048)2.99642869
107negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.99642869
108negative regulation of sister chromatid segregation (GO:0033046)2.99642869
109microtubule depolymerization (GO:0007019)2.99284216
110regulation of nuclear cell cycle DNA replication (GO:0033262)2.98421869
111regulation of double-strand break repair (GO:2000779)2.97885673
112formation of translation preinitiation complex (GO:0001731)2.97809203
113termination of RNA polymerase II transcription (GO:0006369)2.96696993
114translesion synthesis (GO:0019985)2.96514452
115replication fork processing (GO:0031297)2.95818858
116somatic hypermutation of immunoglobulin genes (GO:0016446)2.95638698
117somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95638698
118anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.95633267
119deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.95322768
120monoubiquitinated protein deubiquitination (GO:0035520)2.93528787
121viral transcription (GO:0019083)2.93420001
122ribosome biogenesis (GO:0042254)2.93292847
123regulation of mitotic sister chromatid separation (GO:0010965)2.92915476
124regulation of mitotic sister chromatid segregation (GO:0033047)2.92915476
125regulation of sister chromatid segregation (GO:0033045)2.92915476
126mitochondrial respiratory chain complex assembly (GO:0033108)2.92039339
127energy coupled proton transport, down electrochemical gradient (GO:0015985)2.91018408
128ATP synthesis coupled proton transport (GO:0015986)2.91018408
129establishment of viral latency (GO:0019043)2.90872074
130spliceosomal snRNP assembly (GO:0000387)2.90541578
131chaperone-mediated protein transport (GO:0072321)2.88731969
132cullin deneddylation (GO:0010388)2.88159813
133regulation of DNA endoreduplication (GO:0032875)2.84929308
134negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.84928098
135pseudouridine synthesis (GO:0001522)2.84907996
136DNA strand renaturation (GO:0000733)2.83724804
137folic acid metabolic process (GO:0046655)2.83307057
138protein complex biogenesis (GO:0070271)2.83241565
139protein maturation by protein folding (GO:0022417)2.82470934
140guanosine-containing compound biosynthetic process (GO:1901070)2.81287483
141ribonucleoprotein complex biogenesis (GO:0022613)2.81036526
142translational termination (GO:0006415)2.79346932
143negative regulation of cell cycle G2/M phase transition (GO:1902750)2.78438989
144DNA replication (GO:0006260)2.78323088
145purine nucleobase biosynthetic process (GO:0009113)2.78091801
146establishment of protein localization to mitochondrial membrane (GO:0090151)2.76483316
147negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.76383376
148translational elongation (GO:0006414)2.74402179
149mitotic cell cycle (GO:0000278)2.74237333
150mitochondrial respiratory chain complex I assembly (GO:0032981)2.73850885
151NADH dehydrogenase complex assembly (GO:0010257)2.73850885
152mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.73850885
153regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.73268777
154transcription elongation from RNA polymerase III promoter (GO:0006385)2.72161978
155termination of RNA polymerase III transcription (GO:0006386)2.72161978
156protein deneddylation (GO:0000338)2.71940027

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.37588730
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.50119949
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.15720152
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.77110114
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.86312848
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76017605
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.66470419
8AR_21909140_ChIP-Seq_LNCAP_Human2.59249312
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51031421
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.48989523
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.40797831
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.34557351
13MYC_22102868_ChIP-Seq_BL_Human2.31465752
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.23530384
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20862062
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.14710391
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.10712606
18XRN2_22483619_ChIP-Seq_HELA_Human2.04047625
19E2F7_22180533_ChIP-Seq_HELA_Human10.3864169
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98400357
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97915469
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.97234317
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96906167
24* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90532502
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89332595
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89229420
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.87140767
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.86502568
29* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83944344
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.75414984
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.74343153
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74292862
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72500738
34KDM5A_27292631_Chip-Seq_BREAST_Human1.71754362
35CIITA_25753668_ChIP-Seq_RAJI_Human1.70697205
36* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68589494
37* TTF2_22483619_ChIP-Seq_HELA_Human1.62762255
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60430910
39FOXP3_21729870_ChIP-Seq_TREG_Human1.59702595
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57215895
41* VDR_23849224_ChIP-Seq_CD4+_Human1.56048917
42* GABP_19822575_ChIP-Seq_HepG2_Human1.52770184
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.47373808
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47278203
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42450504
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.40753015
47* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39597496
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37464044
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37346857
50* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.36064044
51SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.33725803
52NANOG_21062744_ChIP-ChIP_HESCs_Human1.33423295
53* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32039824
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32008700
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31286890
56DCP1A_22483619_ChIP-Seq_HELA_Human1.31044242
57* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30934800
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30396186
59* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28907936
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28800284
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28738078
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.27605585
63VDR_21846776_ChIP-Seq_THP-1_Human1.26448035
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25476630
65* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24906592
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21086512
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21039087
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20384019
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20384019
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20384019
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16807281
72FOXP1_21924763_ChIP-Seq_HESCs_Human1.16056323
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13832454
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12967899
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11376502
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10209120
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09436844
78NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09238423
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09049740
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08635585
81TET1_21451524_ChIP-Seq_MESCs_Mouse1.08427870
82P68_20966046_ChIP-Seq_HELA_Human1.07256590
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07059447
84CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06797126
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06299989
86CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04999849
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04746936
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04577996
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02529533
90* SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02529388
91* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01163260
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01105005
93E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00834244
94MYC_18940864_ChIP-ChIP_HL60_Human0.99757321
95PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98432261
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97881012
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.97828846
98* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97419562
99TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96797971
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94726934
101TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93921996
102ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92672881
103HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92526535
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92176881
105SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91757676
106PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91195030
107ELK1_19687146_ChIP-ChIP_HELA_Human0.91085875
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91022586
109FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90674914
110SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90497588
111CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90428192
112NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.89372198
113HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88426912
114ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87715698
115NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.86916826
116TCF7_22412390_ChIP-Seq_EML_Mouse0.85637952
117TFEB_21752829_ChIP-Seq_HELA_Human0.84907506
118PHF8_20622854_ChIP-Seq_HELA_Human0.83687061
119BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82575923
120BCL6_27268052_Chip-Seq_Bcells_Human0.81573117
121NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81467607
122POU5F1_16518401_ChIP-PET_MESCs_Mouse0.81319912
123CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81237524
124CTCF_26484167_Chip-Seq_Bcells_Mouse0.79204976
125GATA1_26923725_Chip-Seq_HPCs_Mouse0.79165111
126SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.78672076
127* LXR_22292898_ChIP-Seq_THP-1_Human0.78397884
128CHD1_26751641_Chip-Seq_LNCaP_Human0.78192326
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77883356
130CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.76239094

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.82247864
2MP0003111_abnormal_nucleus_morphology4.61938479
3MP0010094_abnormal_chromosome_stability4.54001295
4MP0008057_abnormal_DNA_replication4.03490098
5MP0004957_abnormal_blastocyst_morpholog4.00510311
6MP0003077_abnormal_cell_cycle3.94355855
7MP0008877_abnormal_DNA_methylation2.83322218
8MP0008058_abnormal_DNA_repair2.68104076
9MP0003123_paternal_imprinting2.64812285
10MP0002653_abnormal_ependyma_morphology2.50481063
11MP0001730_embryonic_growth_arrest2.46789964
12MP0000350_abnormal_cell_proliferation2.40958104
13MP0008007_abnormal_cellular_replicative2.35861920
14MP0008932_abnormal_embryonic_tissue2.30055555
15MP0006036_abnormal_mitochondrial_physio2.18186913
16MP0003121_genomic_imprinting2.04260899
17MP0001672_abnormal_embryogenesis/_devel2.03802602
18MP0005380_embryogenesis_phenotype2.03802602
19MP0002084_abnormal_developmental_patter2.00056018
20MP0002085_abnormal_embryonic_tissue1.99432422
21MP0002396_abnormal_hematopoietic_system1.97987090
22MP0006292_abnormal_olfactory_placode1.96928632
23MP0001697_abnormal_embryo_size1.95103191
24MP0001529_abnormal_vocalization1.86785816
25MP0010307_abnormal_tumor_latency1.85861251
26MP0010030_abnormal_orbit_morphology1.85304976
27MP0003984_embryonic_growth_retardation1.83611694
28MP0010352_gastrointestinal_tract_polyps1.81923867
29MP0005076_abnormal_cell_differentiation1.79805127
30MP0002088_abnormal_embryonic_growth/wei1.79397837
31MP0003890_abnormal_embryonic-extraembry1.78278510
32MP0002822_catalepsy1.64239781
33MP0002086_abnormal_extraembryonic_tissu1.60795458
34MP0002080_prenatal_lethality1.59945254
35MP0001849_ear_inflammation1.59906999
36MP0002210_abnormal_sex_determination1.58002983
37MP0005645_abnormal_hypothalamus_physiol1.53823049
38MP0001346_abnormal_lacrimal_gland1.53352058
39MP0004197_abnormal_fetal_growth/weight/1.49382325
40MP0009697_abnormal_copulation1.48906329
41MP0003787_abnormal_imprinting1.47833441
42MP0000490_abnormal_crypts_of1.47568810
43MP0003806_abnormal_nucleotide_metabolis1.46874731
44MP0003718_maternal_effect1.46469010
45MP0004147_increased_porphyrin_level1.45425045
46MP0001929_abnormal_gametogenesis1.43474501
47MP0006035_abnormal_mitochondrial_morpho1.42969944
48MP0004264_abnormal_extraembryonic_tissu1.41789879
49MP0000313_abnormal_cell_death1.36498960
50MP0001145_abnormal_male_reproductive1.35924526
51MP0002019_abnormal_tumor_incidence1.30794463
52MP0003937_abnormal_limbs/digits/tail_de1.28495694
53MP0000653_abnormal_sex_gland1.28361496
54MP0001293_anophthalmia1.27570367
55MP0003786_premature_aging1.25761440
56MP0005423_abnormal_somatic_nervous1.24423774
57MP0005257_abnormal_intraocular_pressure1.23946657
58MP0003122_maternal_imprinting1.22419838
59MP0000372_irregular_coat_pigmentation1.19583325
60MP0004808_abnormal_hematopoietic_stem1.19534149
61MP0003119_abnormal_digestive_system1.17093932
62MP0001764_abnormal_homeostasis1.16696342
63MP0008995_early_reproductive_senescence1.16240832
64MP0009379_abnormal_foot_pigmentation1.12491341
65MP0003136_yellow_coat_color1.10836040
66MP0002234_abnormal_pharynx_morphology1.10778592
67MP0000566_synostosis1.10566328
68MP0001545_abnormal_hematopoietic_system1.04739020
69MP0005397_hematopoietic_system_phenotyp1.04739020
70MP0004185_abnormal_adipocyte_glucose1.04148121
71MP0009053_abnormal_anal_canal1.03520702
72MP0009278_abnormal_bone_marrow1.03025183
73MP0000358_abnormal_cell_content/1.02746529
74MP0000428_abnormal_craniofacial_morphol1.01984444
75MP0001119_abnormal_female_reproductive1.00801777
76MP0000631_abnormal_neuroendocrine_gland1.00440580
77MP0003186_abnormal_redox_activity0.99387884
78MP0004145_abnormal_muscle_electrophysio0.98897699
79MP0002249_abnormal_larynx_morphology0.98803710
80MP0003705_abnormal_hypodermis_morpholog0.97994188
81MP0000703_abnormal_thymus_morphology0.96011956
82MP0003315_abnormal_perineum_morphology0.95475673
83MP0005499_abnormal_olfactory_system0.95261420
84MP0005394_taste/olfaction_phenotype0.95261420
85MP0001905_abnormal_dopamine_level0.94897718
86MP0008789_abnormal_olfactory_epithelium0.94529351
87MP0003567_abnormal_fetal_cardiomyocyte0.93664315
88MP0003699_abnormal_female_reproductive0.93209692
89MP0002102_abnormal_ear_morphology0.92975806
90MP0009672_abnormal_birth_weight0.92853286
91MP0003861_abnormal_nervous_system0.92300605
92MP0000432_abnormal_head_morphology0.92126887
93MP0002938_white_spotting0.91642180
94MP0004859_abnormal_synaptic_plasticity0.90712289
95MP0003698_abnormal_male_reproductive0.90415701
96MP0009703_decreased_birth_body0.90331109
97MP0000537_abnormal_urethra_morphology0.89758866
98MP0003755_abnormal_palate_morphology0.89569895
99MP0003935_abnormal_craniofacial_develop0.87862097
100MP0001727_abnormal_embryo_implantation0.86788522
101MP0001915_intracranial_hemorrhage0.86555804
102MP0001286_abnormal_eye_development0.85122207
103MP0005646_abnormal_pituitary_gland0.84963316
104MP0002161_abnormal_fertility/fecundity0.83814887
105MP0002163_abnormal_gland_morphology0.83384374
106MP0005220_abnormal_exocrine_pancreas0.82618387
107MP0000751_myopathy0.82615938
108MP0003656_abnormal_erythrocyte_physiolo0.82321641
109MP0005379_endocrine/exocrine_gland_phen0.82159637
110MP0001188_hyperpigmentation0.80601598
111MP0002697_abnormal_eye_size0.79801695
112MP0002111_abnormal_tail_morphology0.79753005
113MP0002114_abnormal_axial_skeleton0.78232917
114MP0002116_abnormal_craniofacial_bone0.76926608
115MP0002092_abnormal_eye_morphology0.76732329
116MP0000049_abnormal_middle_ear0.75347462
117MP0003646_muscle_fatigue0.75068314
118MP0004133_heterotaxia0.74573995
119MP0004811_abnormal_neuron_physiology0.73580528
120MP0002925_abnormal_cardiovascular_devel0.73446011
121MP0005621_abnormal_cell_physiology0.72698445
122MP0002932_abnormal_joint_morphology0.70079323
123MP0005384_cellular_phenotype0.69856314
124MP0002160_abnormal_reproductive_system0.69033690
125MP0005389_reproductive_system_phenotype0.66758062
126MP0003763_abnormal_thymus_physiology0.66144266
127MP0000003_abnormal_adipose_tissue0.66040250
128MP0004233_abnormal_muscle_weight0.65199106
129MP0005083_abnormal_biliary_tract0.65150427
130MP0003938_abnormal_ear_development0.64784154
131MP0005266_abnormal_metabolism0.64645520
132MP0002132_abnormal_respiratory_system0.64217256
133MP0000733_abnormal_muscle_development0.64190046
134MP0003115_abnormal_respiratory_system0.64152715
135MP0000678_abnormal_parathyroid_gland0.63616728
136MP0002398_abnormal_bone_marrow0.63454112
137MP0004142_abnormal_muscle_tone0.62963953
138MP0002233_abnormal_nose_morphology0.62056443
139MP0002736_abnormal_nociception_after0.60284870
140MP0001968_abnormal_touch/_nociception0.59036852
141MP0006072_abnormal_retinal_apoptosis0.58838663
142MP0008770_decreased_survivor_rate0.58413424

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.35308101
2Abnormal mitochondria in muscle tissue (HP:0008316)4.08988342
3Birth length less than 3rd percentile (HP:0003561)4.06776290
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.98164951
5Hepatocellular necrosis (HP:0001404)3.93273912
6Acute necrotizing encephalopathy (HP:0006965)3.92415218
7Hepatic necrosis (HP:0002605)3.77852191
8Mitochondrial inheritance (HP:0001427)3.75929080
9Acute encephalopathy (HP:0006846)3.67185559
10Ependymoma (HP:0002888)3.63813183
11Patellar aplasia (HP:0006443)3.59468533
12Increased CSF lactate (HP:0002490)3.39131975
13Breast hypoplasia (HP:0003187)3.38363093
14Aplasia/Hypoplasia of the patella (HP:0006498)3.31535607
15Increased intramyocellular lipid droplets (HP:0012240)3.30181982
16Facial hemangioma (HP:0000329)3.28126183
17Abnormality of the labia minora (HP:0012880)3.27675205
18Medulloblastoma (HP:0002885)3.23535837
19Impulsivity (HP:0100710)3.21239219
20Increased hepatocellular lipid droplets (HP:0006565)3.20974727
21Volvulus (HP:0002580)3.16712858
22Progressive macrocephaly (HP:0004481)3.14341079
23Abnormality of chromosome stability (HP:0003220)3.12935460
24Rib fusion (HP:0000902)3.10888119
25Rhabdomyosarcoma (HP:0002859)3.07340970
26Meckel diverticulum (HP:0002245)3.02100362
27Aplasia/Hypoplasia of the uvula (HP:0010293)2.97785593
28Increased muscle lipid content (HP:0009058)2.96272723
29Ectopic kidney (HP:0000086)2.93695531
30Lipid accumulation in hepatocytes (HP:0006561)2.92816989
31Abnormality of the ileum (HP:0001549)2.92509269
32Abnormality of the preputium (HP:0100587)2.92096008
33Aplasia/Hypoplasia of the sacrum (HP:0008517)2.88023976
34Increased nuchal translucency (HP:0010880)2.85725197
35Broad distal phalanx of finger (HP:0009836)2.78325401
36Exercise intolerance (HP:0003546)2.77480688
37Abnormal number of erythroid precursors (HP:0012131)2.74298635
38Abnormality of cells of the erythroid lineage (HP:0012130)2.73501483
39Increased serum lactate (HP:0002151)2.72756991
40Abnormality of glycolysis (HP:0004366)2.72014524
41Neoplasm of the oral cavity (HP:0100649)2.70599783
42Neoplasm of striated muscle (HP:0009728)2.70349993
43Abnormality of the astrocytes (HP:0100707)2.66327453
44Astrocytoma (HP:0009592)2.66327453
45Myelodysplasia (HP:0002863)2.65440178
46Abnormality of the fingertips (HP:0001211)2.64948353
47Small intestinal stenosis (HP:0012848)2.61598117
48Duodenal stenosis (HP:0100867)2.61598117
49Male infertility (HP:0003251)2.60181441
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.59980631
51Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.59980631
52Supernumerary spleens (HP:0009799)2.57400175
53Absent radius (HP:0003974)2.54712183
54Oral leukoplakia (HP:0002745)2.54689064
55Respiratory difficulties (HP:0002880)2.52860756
56Multiple enchondromatosis (HP:0005701)2.52145335
57Renal Fanconi syndrome (HP:0001994)2.51047303
58Selective tooth agenesis (HP:0001592)2.50979052
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.49137443
60Increased serum pyruvate (HP:0003542)2.48958614
61Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.47763936
62Short 4th metacarpal (HP:0010044)2.47763936
63Shawl scrotum (HP:0000049)2.46248328
64Sloping forehead (HP:0000340)2.45903350
65Pancytopenia (HP:0001876)2.45759350
66Lactic acidosis (HP:0003128)2.45197732
67Microvesicular hepatic steatosis (HP:0001414)2.45129331
68Colon cancer (HP:0003003)2.43746748
69Aplasia/Hypoplasia of the sternum (HP:0006714)2.43170414
70Progressive muscle weakness (HP:0003323)2.42587334
71Testicular atrophy (HP:0000029)2.41627256
72Cerebral hypomyelination (HP:0006808)2.41495656
73Progressive microcephaly (HP:0000253)2.37496513
74Aplasia involving forearm bones (HP:0009822)2.37474991
75Absent forearm bone (HP:0003953)2.37474991
76Reticulocytopenia (HP:0001896)2.36919328
77Ragged-red muscle fibers (HP:0003200)2.36309292
78Pendular nystagmus (HP:0012043)2.36232864
79Prominent nose (HP:0000448)2.35641563
80Atresia of the external auditory canal (HP:0000413)2.34020774
81Abnormality of the carotid arteries (HP:0005344)2.31920231
82Cerebral edema (HP:0002181)2.31821305
83Abnormal number of incisors (HP:0011064)2.31056533
84Cortical dysplasia (HP:0002539)2.29635283
85Type I transferrin isoform profile (HP:0003642)2.27840499
86Cafe-au-lait spot (HP:0000957)2.26914117
87Abnormal lung lobation (HP:0002101)2.22499520
88Nephroblastoma (Wilms tumor) (HP:0002667)2.20988000
89Absent thumb (HP:0009777)2.20720732
90Abnormality of the duodenum (HP:0002246)2.18307967
91Basal cell carcinoma (HP:0002671)2.17750622
92Respiratory failure (HP:0002878)2.17706402
93Emotional lability (HP:0000712)2.14777954
94Degeneration of anterior horn cells (HP:0002398)2.12899731
95Abnormality of the anterior horn cell (HP:0006802)2.12899731
96Hyperglycinemia (HP:0002154)2.11329069
97Abdominal situs inversus (HP:0003363)2.10868961
98Abnormality of abdominal situs (HP:0011620)2.10868961
99Glioma (HP:0009733)2.10580568
100Tracheoesophageal fistula (HP:0002575)2.09825315
101Abnormality of DNA repair (HP:0003254)2.08679768
102Overlapping toe (HP:0001845)2.07760465
103Poikiloderma (HP:0001029)2.07012111
104Pallor (HP:0000980)2.06024050
105Horseshoe kidney (HP:0000085)2.05495916
106Macrocytic anemia (HP:0001972)2.04799518
107Proximal placement of thumb (HP:0009623)2.03701103
108Carpal bone hypoplasia (HP:0001498)2.01226880
109Abnormal gallbladder physiology (HP:0012438)2.00984197
110Cholecystitis (HP:0001082)2.00984197
111Embryonal renal neoplasm (HP:0011794)2.00431408
112Short thumb (HP:0009778)1.99439767
113Optic nerve coloboma (HP:0000588)1.99179143
114Missing ribs (HP:0000921)1.98343064
115Abnormality of reticulocytes (HP:0004312)1.98324527
116Abnormality of lateral ventricle (HP:0030047)1.98254738
117Sandal gap (HP:0001852)1.97975867
118Long eyelashes (HP:0000527)1.97510346
119Deviation of the thumb (HP:0009603)1.97430126
120Abnormality of cochlea (HP:0000375)1.97418983
121Oligodactyly (HP:0012165)1.97373752
122Reduced antithrombin III activity (HP:0001976)1.97026756
123High pitched voice (HP:0001620)1.96323642
124Abnormality of chromosome segregation (HP:0002916)1.94281366
125Dicarboxylic aciduria (HP:0003215)1.94203417
126Abnormality of dicarboxylic acid metabolism (HP:0010995)1.94203417
127Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.93531695
128Absent epiphyses (HP:0010577)1.93531695
129Duplicated collecting system (HP:0000081)1.92149957
130Renal duplication (HP:0000075)1.91675916
131Premature ovarian failure (HP:0008209)1.90956707
132Abnormality of the parathyroid morphology (HP:0011766)1.90528660
133Papillary thyroid carcinoma (HP:0002895)1.89856405
134Methylmalonic aciduria (HP:0012120)1.89231420
135Bone marrow hypocellularity (HP:0005528)1.88461539
136Leukodystrophy (HP:0002415)1.88304050
137Microtia (HP:0008551)1.88156063
138Heterotopia (HP:0002282)1.88086427
139Morphological abnormality of the inner ear (HP:0011390)1.87195762
140Cutaneous melanoma (HP:0012056)1.86243200
141Squamous cell carcinoma (HP:0002860)1.86190662
142Clubbing of toes (HP:0100760)1.85141152
143Hypoplasia of the capital femoral epiphysis (HP:0003090)1.84051520
144Triphalangeal thumb (HP:0001199)1.83897679
145Agnosia (HP:0010524)1.83285379
146Abnormality of the heme biosynthetic pathway (HP:0010472)1.83045226
147Aplastic anemia (HP:0001915)1.82549628
148Sparse lateral eyebrow (HP:0005338)1.81222784
149Neoplasm of the pancreas (HP:0002894)1.80690132
150Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.80552185
151Aplasia/hypoplasia of the humerus (HP:0006507)1.80451968
152Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.79643201
153Broad thumb (HP:0011304)1.78921740
154Acute lymphatic leukemia (HP:0006721)1.76795134
155Gastrointestinal carcinoma (HP:0002672)1.76777160
156Malignant gastrointestinal tract tumors (HP:0006749)1.76777160
157Abnormality of the renal collecting system (HP:0004742)1.75757084
158Abnormality of the phalanges of the hallux (HP:0010057)1.75209959
159Broad palm (HP:0001169)1.74888838
160Breast aplasia (HP:0100783)1.74805400
161Exertional dyspnea (HP:0002875)1.74502028
162Abnormal protein N-linked glycosylation (HP:0012347)1.74411240
163Abnormal glycosylation (HP:0012345)1.74411240
164Premature graying of hair (HP:0002216)1.74145803
165Hemivertebrae (HP:0002937)1.73324921
166Aplasia/Hypoplasia of the breasts (HP:0010311)1.70294720
167Abnormality of the 4th metacarpal (HP:0010012)1.69381821

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.95046511
2CDK124.49113673
3VRK23.99245555
4NEK23.53238884
5TTK3.01941733
6BUB12.86946438
7NME22.65354404
8WEE12.61770266
9EEF2K2.52134141
10LATS12.36707698
11BCKDK2.36557147
12PLK42.34079364
13CHEK22.17602886
14CDK72.13847680
15NEK12.12487503
16ARAF2.11698433
17CDK82.09861355
18PLK12.06641882
19LATS22.02962166
20MAP3K61.88714144
21SRPK11.80967928
22AURKB1.77276274
23PIM21.77231770
24MAP3K101.76776434
25STK161.74104843
26ATR1.69587883
27CDK41.63517381
28SIK21.62946069
29CHEK11.60470334
30NME11.56127896
31RPS6KB21.48004844
32STK101.47452171
33ZAK1.45549522
34TAOK11.43661025
35STK38L1.39398795
36PBK1.28961494
37MAP3K81.26976587
38PASK1.24000906
39TLK11.22690002
40BRSK21.22639731
41ATM1.21856375
42BRD41.20903179
43EIF2AK11.19261204
44PLK31.17878880
45STK31.17034926
46TESK11.15996584
47* CDK21.15706103
48MKNK21.15377814
49UHMK11.13427886
50MKNK11.09457390
51BRSK11.09334266
52TSSK61.08144197
53AURKA1.06470167
54KDR1.01525384
55SMG11.01411008
56VRK11.01176849
57DYRK31.01129007
58ICK1.00421296
59ACVR1B0.99360331
60MELK0.96791975
61STK40.96641194
62CSNK1G30.95376334
63TESK20.95300615
64ALK0.93917580
65DYRK20.92873806
66CDK180.92554430
67PAK40.92070171
68CDK140.91478329
69MTOR0.91230314
70ERN10.91015142
71CDK10.89074001
72CDK60.86605660
73PKN20.85973474
74RPS6KA40.81995303
75CDK90.81130721
76TYRO30.79681753
77BRAF0.79121189
78MAP2K70.78529958
79DAPK10.74135498
80MOS0.72533457
81PNCK0.72394073
82CCNB10.71862035
83MINK10.70521269
84RAF10.68241682
85PDK20.67527014
86PHKG10.67097582
87PHKG20.67097582
88ERBB40.66732369
89LIMK10.66379065
90PRKD30.65847212
91EIF2AK30.65709202
92CSNK1E0.65134634
93PIM10.63801422
94TNIK0.63128641
95CSNK1A1L0.62086940
96CSNK1G20.58923397
97MAPK140.57236767
98MAPK110.55125191
99MAPKAPK30.54955181
100MAP3K110.54828977
101DYRK1B0.53776360
102AKT20.52429238
103PAK10.51890583
104CSNK2A20.49473684
105MAPKAPK50.49174619
106TAOK30.48366146
107CSNK1G10.48136945
108CAMK1D0.47793379
109NUAK10.47041269
110PRKD20.46821611
111TRIB30.46535728
112PKN10.44983850
113PRKDC0.44945150
114EIF2AK20.44553116
115CSNK1D0.44432707
116TAF10.43865983
117GSK3B0.43819140
118MAP3K90.43227396
119STK380.43220917
120PRKCI0.43203498
121KSR20.43166476
122RPS6KA50.43133314
123HIPK20.42759520
124KSR10.41287156
125BCR0.41027727
126MARK10.40556825
127GRK60.40003932
128LRRK20.39748273
129CSNK2A10.39364501
130TRIM280.37558827
131MARK30.37378764
132DMPK0.37362524
133ABL20.35397929
134RPS6KA10.35015028
135EPHA20.34981016
136MAPK100.34876868
137AKT10.34247891
138TGFBR10.32711194
139MAPK10.30656332
140CDK11A0.30497112
141PAK20.28913488
142CAMK1G0.26983997
143SCYL20.25788205
144PAK60.21765415
145CDK150.20656883

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.74335849
2Mismatch repair_Homo sapiens_hsa034304.18495813
3Cell cycle_Homo sapiens_hsa041103.53510209
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.52912906
5RNA transport_Homo sapiens_hsa030133.36554326
6Spliceosome_Homo sapiens_hsa030403.31381855
7Homologous recombination_Homo sapiens_hsa034403.15047225
8Base excision repair_Homo sapiens_hsa034103.08957769
9Fanconi anemia pathway_Homo sapiens_hsa034602.64822669
10Nucleotide excision repair_Homo sapiens_hsa034202.64589299
11Basal transcription factors_Homo sapiens_hsa030222.61341550
12mRNA surveillance pathway_Homo sapiens_hsa030152.58178290
13RNA degradation_Homo sapiens_hsa030182.47753813
14Oxidative phosphorylation_Homo sapiens_hsa001902.31186073
15RNA polymerase_Homo sapiens_hsa030202.26845362
16Parkinsons disease_Homo sapiens_hsa050122.25583884
17One carbon pool by folate_Homo sapiens_hsa006702.23420369
18Non-homologous end-joining_Homo sapiens_hsa034502.03280262
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.89846702
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.89220645
21Folate biosynthesis_Homo sapiens_hsa007901.88730846
22Ribosome_Homo sapiens_hsa030101.83136664
23Pyrimidine metabolism_Homo sapiens_hsa002401.74614946
24Huntingtons disease_Homo sapiens_hsa050161.71989593
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.69313803
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66393440
27p53 signaling pathway_Homo sapiens_hsa041151.64517394
28Oocyte meiosis_Homo sapiens_hsa041141.57029749
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.49823521
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.37300138
31Alzheimers disease_Homo sapiens_hsa050101.34904911
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32041265
33Carbon metabolism_Homo sapiens_hsa012001.28681126
34MicroRNAs in cancer_Homo sapiens_hsa052061.26433387
35Protein export_Homo sapiens_hsa030601.23987709
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22974333
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20589858
38Pyruvate metabolism_Homo sapiens_hsa006201.20552411
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18374934
40Systemic lupus erythematosus_Homo sapiens_hsa053221.10494090
41Thyroid cancer_Homo sapiens_hsa052161.10422112
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09699024
43Viral carcinogenesis_Homo sapiens_hsa052031.05997856
44HTLV-I infection_Homo sapiens_hsa051661.02032836
45Colorectal cancer_Homo sapiens_hsa052101.00634535
46Herpes simplex infection_Homo sapiens_hsa051681.00404951
47Notch signaling pathway_Homo sapiens_hsa043300.99078471
48Epstein-Barr virus infection_Homo sapiens_hsa051690.96442622
49Chronic myeloid leukemia_Homo sapiens_hsa052200.96362594
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96090806
51Hippo signaling pathway_Homo sapiens_hsa043900.95270793
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95270666
53Basal cell carcinoma_Homo sapiens_hsa052170.91515324
54Purine metabolism_Homo sapiens_hsa002300.90937918
55TGF-beta signaling pathway_Homo sapiens_hsa043500.88970060
56Cardiac muscle contraction_Homo sapiens_hsa042600.88258093
57Fructose and mannose metabolism_Homo sapiens_hsa000510.88173583
58Small cell lung cancer_Homo sapiens_hsa052220.85808334
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85374323
60mTOR signaling pathway_Homo sapiens_hsa041500.84832069
61Bladder cancer_Homo sapiens_hsa052190.84790676
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84651809
63Fatty acid elongation_Homo sapiens_hsa000620.84607586
64Non-small cell lung cancer_Homo sapiens_hsa052230.84022131
65Pancreatic cancer_Homo sapiens_hsa052120.81423461
66Proteasome_Homo sapiens_hsa030500.78924373
67Glutathione metabolism_Homo sapiens_hsa004800.76218179
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76134507
69Vitamin B6 metabolism_Homo sapiens_hsa007500.75565548
70Lysine degradation_Homo sapiens_hsa003100.73677984
71Hedgehog signaling pathway_Homo sapiens_hsa043400.68620984
72Adherens junction_Homo sapiens_hsa045200.68058703
73Metabolic pathways_Homo sapiens_hsa011000.64892756
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.63840981
75Wnt signaling pathway_Homo sapiens_hsa043100.63273473
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62913024
77Prostate cancer_Homo sapiens_hsa052150.60504080
78Endometrial cancer_Homo sapiens_hsa052130.58450705
79Alcoholism_Homo sapiens_hsa050340.57848496
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57370896
81Propanoate metabolism_Homo sapiens_hsa006400.57160779
82Biosynthesis of amino acids_Homo sapiens_hsa012300.57134678
83Hepatitis B_Homo sapiens_hsa051610.56525146
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56308994
85Butanoate metabolism_Homo sapiens_hsa006500.51786490
86N-Glycan biosynthesis_Homo sapiens_hsa005100.51508776
87Antigen processing and presentation_Homo sapiens_hsa046120.50956758
88Pathways in cancer_Homo sapiens_hsa052000.50609614
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.50607135
90VEGF signaling pathway_Homo sapiens_hsa043700.46487620
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.45791423
92Acute myeloid leukemia_Homo sapiens_hsa052210.45569787
93Arginine and proline metabolism_Homo sapiens_hsa003300.45213562
94Melanoma_Homo sapiens_hsa052180.44345787
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40761704
96Glioma_Homo sapiens_hsa052140.40554986
97Renal cell carcinoma_Homo sapiens_hsa052110.39692156
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38874673
99Prolactin signaling pathway_Homo sapiens_hsa049170.37914765
100FoxO signaling pathway_Homo sapiens_hsa040680.37282604
101Steroid biosynthesis_Homo sapiens_hsa001000.36684523
102HIF-1 signaling pathway_Homo sapiens_hsa040660.36026105
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35142438
104Apoptosis_Homo sapiens_hsa042100.35089767
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34557582
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33546130
107Selenocompound metabolism_Homo sapiens_hsa004500.33234780
108Tight junction_Homo sapiens_hsa045300.33111213
109Primary immunodeficiency_Homo sapiens_hsa053400.32409059
110Pentose phosphate pathway_Homo sapiens_hsa000300.32313027
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.32138566
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30771164
113Sulfur relay system_Homo sapiens_hsa041220.30642072
114Fatty acid metabolism_Homo sapiens_hsa012120.30408257
115Circadian rhythm_Homo sapiens_hsa047100.30291861
116Dorso-ventral axis formation_Homo sapiens_hsa043200.29555907
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29192798
118Regulation of autophagy_Homo sapiens_hsa041400.27808930
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26607670
120Galactose metabolism_Homo sapiens_hsa000520.25894686
121Peroxisome_Homo sapiens_hsa041460.25823653
122Choline metabolism in cancer_Homo sapiens_hsa052310.24687092
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24467107
124Shigellosis_Homo sapiens_hsa051310.24069167
125Proteoglycans in cancer_Homo sapiens_hsa052050.23770940
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23586976
127Phenylalanine metabolism_Homo sapiens_hsa003600.23419660
128Estrogen signaling pathway_Homo sapiens_hsa049150.22932621
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22002766
130Nicotine addiction_Homo sapiens_hsa050330.20401572
131Synaptic vesicle cycle_Homo sapiens_hsa047210.19886214
132Influenza A_Homo sapiens_hsa051640.19180060
133AMPK signaling pathway_Homo sapiens_hsa041520.18359804
134B cell receptor signaling pathway_Homo sapiens_hsa046620.18295305
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.17710091
136MAPK signaling pathway_Homo sapiens_hsa040100.17439096
137Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16287326
138Phototransduction_Homo sapiens_hsa047440.15674595
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.15364493
140ErbB signaling pathway_Homo sapiens_hsa040120.14803578
141Tyrosine metabolism_Homo sapiens_hsa003500.13532396
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13068120
143Viral myocarditis_Homo sapiens_hsa054160.12991847
144T cell receptor signaling pathway_Homo sapiens_hsa046600.12494679
145Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.12312831
146Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.11176281
147Glucagon signaling pathway_Homo sapiens_hsa049220.10745698
148Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.10079591
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.06041411
150Vibrio cholerae infection_Homo sapiens_hsa051100.02577895
151SNARE interactions in vesicular transport_Homo sapiens_hsa041300.00372356
152Amphetamine addiction_Homo sapiens_hsa05031-0.0145517
153Taurine and hypotaurine metabolism_Homo sapiens_hsa00430-0.0069893
154Maturity onset diabetes of the young_Homo sapiens_hsa04950-0.0039170

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