HIST1H1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome assembly (GO:0006335)9.09034813
2DNA replication-dependent nucleosome organization (GO:0034723)9.09034813
3regulation of DNA methylation (GO:0044030)8.11875264
4regulation of histone H3-K9 methylation (GO:0051570)7.80235085
5chromatin assembly (GO:0031497)7.52256945
6regulation of meiosis I (GO:0060631)7.15610938
7nuclear pore complex assembly (GO:0051292)6.58349269
8regulation of female gonad development (GO:2000194)6.48310048
9nuclear pore organization (GO:0006999)6.30525318
10* nucleosome assembly (GO:0006334)6.04127815
11meiotic cell cycle (GO:0051321)5.93524356
12DNA unwinding involved in DNA replication (GO:0006268)5.91811999
13mitotic chromosome condensation (GO:0007076)5.84492483
14piRNA metabolic process (GO:0034587)5.70174410
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.69383842
16chromatin assembly or disassembly (GO:0006333)5.65154624
17establishment of chromosome localization (GO:0051303)5.38728023
18protein localization to kinetochore (GO:0034501)5.38462048
19regulation of acrosome reaction (GO:0060046)5.37266143
20* nucleosome organization (GO:0034728)5.31840815
21retinal cone cell development (GO:0046549)5.25491037
22positive regulation of histone H3-K4 methylation (GO:0051571)5.24668123
23centriole replication (GO:0007099)5.14443346
24* protein-DNA complex assembly (GO:0065004)5.12158872
25DNA methylation involved in gamete generation (GO:0043046)5.02068655
26sister chromatid segregation (GO:0000819)4.93582242
27pore complex assembly (GO:0046931)4.92807163
28negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.87494700
29female gamete generation (GO:0007292)4.86829215
30regulation of cell maturation (GO:1903429)4.79720222
31negative regulation of histone methylation (GO:0031061)4.71083502
32* protein-DNA complex subunit organization (GO:0071824)4.66371112
33protein localization to chromosome, centromeric region (GO:0071459)4.61035816
34antibacterial humoral response (GO:0019731)4.46451741
35chromatin remodeling at centromere (GO:0031055)4.45796899
36DNA replication initiation (GO:0006270)4.32611959
37CENP-A containing nucleosome assembly (GO:0034080)4.32159195
38regulation of retinoic acid receptor signaling pathway (GO:0048385)4.30951155
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.29383937
40mitotic sister chromatid segregation (GO:0000070)4.28146597
41DNA duplex unwinding (GO:0032508)4.27506828
42DNA geometric change (GO:0032392)4.26580445
43regulation of gene silencing (GO:0060968)4.22198573
44folic acid-containing compound biosynthetic process (GO:0009396)4.19860319
45mitotic sister chromatid cohesion (GO:0007064)4.17360359
46DNA replication checkpoint (GO:0000076)4.15840182
47antimicrobial humoral response (GO:0019730)4.15437912
48innate immune response in mucosa (GO:0002227)4.14735093
49oocyte development (GO:0048599)4.13660177
50synapsis (GO:0007129)4.11046333
51regulation of posttranscriptional gene silencing (GO:0060147)4.10694893
52regulation of gene silencing by miRNA (GO:0060964)4.10694893
53regulation of gene silencing by RNA (GO:0060966)4.10694893
54chromosome condensation (GO:0030261)4.04311780
55mitotic nuclear envelope disassembly (GO:0007077)4.04182466
56male meiosis I (GO:0007141)4.01392611
57regulation of spindle checkpoint (GO:0090231)3.98880503
58protein K6-linked ubiquitination (GO:0085020)3.98388814
59regulation of double-strand break repair via homologous recombination (GO:0010569)3.95198878
60DNA replication-independent nucleosome assembly (GO:0006336)3.94383777
61DNA replication-independent nucleosome organization (GO:0034724)3.94383777
62positive regulation of chromosome segregation (GO:0051984)3.93377604
63multicellular organism reproduction (GO:0032504)3.88851867
64regulation of centriole replication (GO:0046599)3.88043109
65DNA strand elongation involved in DNA replication (GO:0006271)3.87902820
66regulation of steroid hormone secretion (GO:2000831)3.87643213
67negative regulation of reproductive process (GO:2000242)3.85077097
68nuclear envelope disassembly (GO:0051081)3.85050827
69membrane disassembly (GO:0030397)3.85050827
70histone exchange (GO:0043486)3.84515627
71IMP biosynthetic process (GO:0006188)3.84450587
72dosage compensation (GO:0007549)3.83487734
73primitive streak formation (GO:0090009)3.83360664
74kinetochore organization (GO:0051383)3.82501487
75regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.80385197
76positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.78722091
77positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.78722091
78positive regulation of mitotic sister chromatid separation (GO:1901970)3.78722091
79DNA topological change (GO:0006265)3.78211304
80pre-miRNA processing (GO:0031054)3.75788495
81positive regulation of gastrulation (GO:2000543)3.75672051
82positive regulation of histone methylation (GO:0031062)3.75449613
83mitotic recombination (GO:0006312)3.73906588
84chromosome organization involved in meiosis (GO:0070192)3.73285393
85male meiosis (GO:0007140)3.72901878
86translesion synthesis (GO:0019985)3.72225898
87regulation of RNA export from nucleus (GO:0046831)3.68929657
88histone-serine phosphorylation (GO:0035404)3.68599840
89regulation of sister chromatid cohesion (GO:0007063)3.67008434
90DNA strand elongation (GO:0022616)3.66167745
91regulation of helicase activity (GO:0051095)3.64263438
92gene silencing by RNA (GO:0031047)3.63730948
93DNA conformation change (GO:0071103)3.59878148
94regulation of centrosome cycle (GO:0046605)3.58884462
95meiotic chromosome segregation (GO:0045132)3.57903840
96DNA packaging (GO:0006323)3.56132593
97telomere maintenance via semi-conservative replication (GO:0032201)3.55334507
98negative regulation of DNA-dependent DNA replication (GO:2000104)3.54744266
99negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.54340554
100meiotic cell cycle process (GO:1903046)3.53622966
101regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.49708929
102regulation of mitotic spindle checkpoint (GO:1903504)3.49708929
103centriole assembly (GO:0098534)3.46051387
104centrosome duplication (GO:0051298)3.46032198
105regulation of mitotic sister chromatid separation (GO:0010965)3.45747674
106regulation of mitotic sister chromatid segregation (GO:0033047)3.45747674
107regulation of sister chromatid segregation (GO:0033045)3.45747674
108regulation of meiosis (GO:0040020)3.45557001
109synaptonemal complex assembly (GO:0007130)3.43889619
110IMP metabolic process (GO:0046040)3.42070443
111meiosis I (GO:0007127)3.38695452
112attachment of spindle microtubules to kinetochore (GO:0008608)3.38621167
113DNA synthesis involved in DNA repair (GO:0000731)3.38451602
114ATP-dependent chromatin remodeling (GO:0043044)3.37715989
115regulation of chromosome segregation (GO:0051983)3.37474014
116meiotic nuclear division (GO:0007126)3.36780274
117kinetochore assembly (GO:0051382)3.35739862
118regulation of translational fidelity (GO:0006450)3.35314523
119regulation of spindle organization (GO:0090224)3.32733211
120negative regulation of DNA repair (GO:0045738)3.31506422
121telomere maintenance via recombination (GO:0000722)3.31497778
122resolution of meiotic recombination intermediates (GO:0000712)3.30899120
123postreplication repair (GO:0006301)3.30773296
124anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.30770397
125regulation of centrosome duplication (GO:0010824)3.30549696
126mitotic G2/M transition checkpoint (GO:0044818)3.30485889
127somatic hypermutation of immunoglobulin genes (GO:0016446)3.29852102
128somatic diversification of immune receptors via somatic mutation (GO:0002566)3.29852102
129mitotic metaphase plate congression (GO:0007080)3.28915942
130regulation of histone methylation (GO:0031060)3.27368801
131regulation of DNA endoreduplication (GO:0032875)3.27134036
132metaphase plate congression (GO:0051310)3.23113444
133protein localization to chromosome (GO:0034502)3.22855601
134regulation of mitotic spindle organization (GO:0060236)3.21606128
135microtubule depolymerization (GO:0007019)3.21569270
136histone lysine demethylation (GO:0070076)3.19681821
137oogenesis (GO:0048477)3.18608366
138transcription elongation from RNA polymerase I promoter (GO:0006362)3.18476143
139genitalia morphogenesis (GO:0035112)3.17231252
140telomere maintenance (GO:0000723)3.16731328
141neuron fate determination (GO:0048664)3.16588226
142nucleotide-excision repair, DNA gap filling (GO:0006297)3.15519999
143mucosal immune response (GO:0002385)3.13414690
144regulation of mitotic metaphase/anaphase transition (GO:0030071)3.13400682
145telomere organization (GO:0032200)3.13270178
146spindle checkpoint (GO:0031577)3.13027836
147regulation of G2/M transition of mitotic cell cycle (GO:0010389)3.12873675
148spindle assembly involved in mitosis (GO:0090307)3.12546755
149synaptonemal complex organization (GO:0070193)3.12260452
150chromosome segregation (GO:0007059)3.11830148
151histone demethylation (GO:0016577)3.10465601
152negative regulation of histone modification (GO:0031057)3.05389053
153regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.05217540
154maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.04480070
155relaxation of smooth muscle (GO:0044557)3.03754587
156proteasome assembly (GO:0043248)2.95484628
157nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.95318254
158binding of sperm to zona pellucida (GO:0007339)2.95155431
159negative regulation of chromosome segregation (GO:0051985)2.92755628
160glycine transport (GO:0015816)2.91876082

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.09184171
2EZH2_22144423_ChIP-Seq_EOC_Human7.17470597
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.89170892
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.59148751
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.33050863
6* SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.22346933
7* BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.21187476
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.19058410
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.98995538
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.68785130
11MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.44150613
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.43861627
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.43861627
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.43861627
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.37884087
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.28586672
17* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19261315
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15830119
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.12649079
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04008921
21* FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse14.2935191
22* SOX2_16153702_ChIP-ChIP_HESCs_Human1.97217318
23* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.90231781
24SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.84274601
25IRF1_19129219_ChIP-ChIP_H3396_Human1.82937329
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.82751869
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.81860692
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.81582847
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79301062
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.78511972
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.77778004
32* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.77268847
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74605693
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.72819974
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72050392
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67068767
37* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64501477
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64124971
39* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.61501470
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61473831
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59340320
42AR_21909140_ChIP-Seq_LNCAP_Human1.58813773
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50366091
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49143199
45GATA1_26923725_Chip-Seq_HPCs_Mouse1.46187138
46* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.42922149
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.39160375
48EWS_26573619_Chip-Seq_HEK293_Human1.36462821
49GBX2_23144817_ChIP-Seq_PC3_Human1.36259331
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35274065
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34092931
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31569560
53VDR_23849224_ChIP-Seq_CD4+_Human1.31544204
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31294590
55HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29648635
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25749086
57* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.21800738
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21605777
59* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20969243
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20316613
61* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19323705
62ELK1_19687146_ChIP-ChIP_HELA_Human1.18497416
63* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17329774
64* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.17211443
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15851842
66* NANOG_16153702_ChIP-ChIP_HESCs_Human1.14815389
67* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14512431
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11546181
69MYC_22102868_ChIP-Seq_BL_Human1.10985444
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10790023
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09263076
72* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05421579
73ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05035012
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04814261
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04033198
76FUS_26573619_Chip-Seq_HEK293_Human1.02634642
77SALL4_22934838_ChIP-ChIP_CD34+_Human1.01691855
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01253819
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01067527
80FOXP3_21729870_ChIP-Seq_TREG_Human1.00639400
81FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99733840
82XRN2_22483619_ChIP-Seq_HELA_Human0.98665864
83* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97708364
84YY1_21170310_ChIP-Seq_MESCs_Mouse0.97624848
85P300_19829295_ChIP-Seq_ESCs_Human0.97548400
86EP300_21415370_ChIP-Seq_HL-1_Mouse0.97151734
87CBP_20019798_ChIP-Seq_JUKART_Human0.96481799
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96481799
89TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96200294
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95305330
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93825820
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92607454
93HTT_18923047_ChIP-ChIP_STHdh_Human0.92553412
94NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91882776
95DCP1A_22483619_ChIP-Seq_HELA_Human0.90734265
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90125635
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90094215
98HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.89701025
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89456216
100LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86615306
101CREB1_15753290_ChIP-ChIP_HEK293T_Human0.85598236
102* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85569364
103SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.85380261
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84594766
105MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.84026549
106EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.83972744
107* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.83069942
108NANOG_21062744_ChIP-ChIP_HESCs_Human0.82441820
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80799367
110TP53_16413492_ChIP-PET_HCT116_Human0.80641037
111KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.80538843
112TCF4_23295773_ChIP-Seq_U87_Human0.79439836
113NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.79204936
114TAF15_26573619_Chip-Seq_HEK293_Human0.78544157
115ETS1_22383799_ChIP-Seq_G1ME_Mouse0.78040926
116THAP11_20581084_ChIP-Seq_MESCs_Mouse0.77597869
117VDR_22108803_ChIP-Seq_LS180_Human0.76693540
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.76317555
119SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.76027225
120STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.75914680
121KDM5A_27292631_Chip-Seq_BREAST_Human0.74923128
122* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74552815
123ZNF274_21170338_ChIP-Seq_K562_Hela0.74182615
124SMAD4_21799915_ChIP-Seq_A2780_Human0.73806373
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.73273500
126* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.73176626
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.72746419
128* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.72621643
129MYC_18940864_ChIP-ChIP_HL60_Human0.72588050
130ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.72521750
131CIITA_25753668_ChIP-Seq_RAJI_Human0.72489849
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.71928047
133PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71575928
134EST1_17652178_ChIP-ChIP_JURKAT_Human0.71003469
135CBP_21632823_ChIP-Seq_H3396_Human0.70215681
136ELK1_22589737_ChIP-Seq_MCF10A_Human0.69343483
137PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.69331591
138AR_25329375_ChIP-Seq_VCAP_Human0.68633245
139GABP_19822575_ChIP-Seq_HepG2_Human0.68508647
140* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.67145463
141TTF2_22483619_ChIP-Seq_HELA_Human0.66807204
142HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.66586965
143SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.66553060
144NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.65546850
145* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.65401885
146RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.63810177
147VDR_21846776_ChIP-Seq_THP-1_Human0.63615960
148POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.63418864
149CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.63317026
150KLF4_18555785_ChIP-Seq_MESCs_Mouse0.62812322
151TP63_19390658_ChIP-ChIP_HaCaT_Human0.62232245
152TCF3_18692474_ChIP-Seq_MEFs_Mouse0.61757285
153SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.61432455
154ETS1_20019798_ChIP-Seq_JURKAT_Human0.61002662

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.20463452
2MP0003111_abnormal_nucleus_morphology4.24476580
3MP0008789_abnormal_olfactory_epithelium4.08945842
4MP0006292_abnormal_olfactory_placode3.96897600
5MP0010307_abnormal_tumor_latency3.84878251
6MP0008057_abnormal_DNA_replication3.82993333
7MP0003077_abnormal_cell_cycle3.76585276
8MP0003693_abnormal_embryo_hatching3.64408939
9MP0005394_taste/olfaction_phenotype3.44152479
10MP0005499_abnormal_olfactory_system3.44152479
11MP0004957_abnormal_blastocyst_morpholog3.32442671
12MP0010352_gastrointestinal_tract_polyps3.08683298
13MP0005395_other_phenotype2.87263617
14MP0008877_abnormal_DNA_methylation2.84168007
15MP0008058_abnormal_DNA_repair2.81247472
16MP0003123_paternal_imprinting2.81116403
17MP0010234_abnormal_vibrissa_follicle2.80722890
18MP0003705_abnormal_hypodermis_morpholog2.67827575
19MP0003121_genomic_imprinting2.47978185
20MP0001730_embryonic_growth_arrest2.36957187
21MP0008007_abnormal_cellular_replicative2.35003349
22MP0000350_abnormal_cell_proliferation2.29508179
23MP0002234_abnormal_pharynx_morphology2.26914883
24MP0005076_abnormal_cell_differentiation2.22063638
25MP0008932_abnormal_embryonic_tissue2.17319385
26MP0002139_abnormal_hepatobiliary_system2.12688719
27MP0003699_abnormal_female_reproductive2.01098992
28MP0003950_abnormal_plasma_membrane1.98140142
29MP0006054_spinal_hemorrhage1.90005477
30MP0004197_abnormal_fetal_growth/weight/1.88112910
31MP0002084_abnormal_developmental_patter1.87215803
32MP0005380_embryogenesis_phenotype1.81931019
33MP0001672_abnormal_embryogenesis/_devel1.81931019
34MP0000537_abnormal_urethra_morphology1.81309054
35MP0002086_abnormal_extraembryonic_tissu1.79099727
36MP0002138_abnormal_hepatobiliary_system1.79028132
37MP0001697_abnormal_embryo_size1.78307093
38MP0002085_abnormal_embryonic_tissue1.78181325
39MP0005360_urolithiasis1.77963259
40MP0004808_abnormal_hematopoietic_stem1.75528747
41MP0002160_abnormal_reproductive_system1.74553122
42MP0002396_abnormal_hematopoietic_system1.70493476
43MP0003787_abnormal_imprinting1.63001602
44MP0002080_prenatal_lethality1.59327000
45MP0003984_embryonic_growth_retardation1.57152399
46MP0003786_premature_aging1.55614600
47MP0002088_abnormal_embryonic_growth/wei1.54474442
48MP0000762_abnormal_tongue_morphology1.50196901
49MP0003183_abnormal_peptide_metabolism1.46629152
50MP0003937_abnormal_limbs/digits/tail_de1.43359963
51MP0003890_abnormal_embryonic-extraembry1.41330444
52MP0002019_abnormal_tumor_incidence1.37060587
53MP0000490_abnormal_crypts_of1.33339381
54* MP0002161_abnormal_fertility/fecundity1.33157296
55MP0002233_abnormal_nose_morphology1.31270642
56MP0001293_anophthalmia1.30338299
57MP0000703_abnormal_thymus_morphology1.25139649
58MP0000313_abnormal_cell_death1.24155446
59MP0003252_abnormal_bile_duct1.24146309
60MP0002009_preneoplasia1.19508660
61MP0001119_abnormal_female_reproductive1.16055490
62MP0002210_abnormal_sex_determination1.12515074
63MP0002697_abnormal_eye_size1.11202274
64MP0001915_intracranial_hemorrhage1.10456903
65MP0009703_decreased_birth_body1.09991251
66MP0001929_abnormal_gametogenesis1.09444659
67MP0002092_abnormal_eye_morphology1.09243895
68MP0001984_abnormal_olfaction1.08758826
69MP0002111_abnormal_tail_morphology1.05739257
70MP0010678_abnormal_skin_adnexa1.05034520
71MP0009053_abnormal_anal_canal1.04504223
72MP0000566_synostosis1.04368097
73MP0003806_abnormal_nucleotide_metabolis1.02896735
74MP0001145_abnormal_male_reproductive1.02864790
75MP0000733_abnormal_muscle_development1.01601551
76MP0003567_abnormal_fetal_cardiomyocyte0.97471399
77MP0003566_abnormal_cell_adhesion0.97062237
78MP0002722_abnormal_immune_system0.93514436
79MP0009780_abnormal_chondrocyte_physiolo0.93513698
80MP0002166_altered_tumor_susceptibility0.93462719
81MP0005647_abnormal_sex_gland0.92864435
82MP0004233_abnormal_muscle_weight0.91970804
83MP0009672_abnormal_birth_weight0.91177797
84* MP0003698_abnormal_male_reproductive0.91111773
85MP0002398_abnormal_bone_marrow0.90858063
86MP0003656_abnormal_erythrocyte_physiolo0.90385791
87MP0003879_abnormal_hair_cell0.89473835
88MP0001849_ear_inflammation0.88841172
89MP0000427_abnormal_hair_cycle0.88570418
90MP0008770_decreased_survivor_rate0.87985316
91MP0000653_abnormal_sex_gland0.87532966
92MP0010030_abnormal_orbit_morphology0.87125607
93MP0003861_abnormal_nervous_system0.85782607
94MP0002796_impaired_skin_barrier0.85108701
95MP0003119_abnormal_digestive_system0.85098608
96MP0000689_abnormal_spleen_morphology0.83557943
97MP0001286_abnormal_eye_development0.83079822
98MP0005621_abnormal_cell_physiology0.82917901
99MP0003755_abnormal_palate_morphology0.82561029
100MP0002925_abnormal_cardiovascular_devel0.82240368
101MP0000428_abnormal_craniofacial_morphol0.81462357
102MP0005384_cellular_phenotype0.80743014
103MP0000049_abnormal_middle_ear0.79831216
104MP0003136_yellow_coat_color0.79641777
105MP0002006_tumorigenesis0.78545528
106MP0002638_abnormal_pupillary_reflex0.77968080
107MP0000432_abnormal_head_morphology0.77303356
108MP0005623_abnormal_meninges_morphology0.77019946
109MP0000569_abnormal_digit_pigmentation0.75045189
110MP0009697_abnormal_copulation0.74909293
111MP0009278_abnormal_bone_marrow0.73413877
112MP0003718_maternal_effect0.73079882
113MP0000631_abnormal_neuroendocrine_gland0.72938351
114MP0006072_abnormal_retinal_apoptosis0.72526805
115MP0004185_abnormal_adipocyte_glucose0.72519927
116MP0004147_increased_porphyrin_level0.70973438
117* MP0005410_abnormal_fertilization0.70450888
118MP0005023_abnormal_wound_healing0.70396836
119MP0003935_abnormal_craniofacial_develop0.70110915
120MP0001324_abnormal_eye_pigmentation0.69833552
121MP0003283_abnormal_digestive_organ0.67934375
122MP0010368_abnormal_lymphatic_system0.64580096
123MP0003115_abnormal_respiratory_system0.64367753
124MP0005187_abnormal_penis_morphology0.63982822
125MP0005397_hematopoietic_system_phenotyp0.63417070
126MP0001545_abnormal_hematopoietic_system0.63417070
127MP0005501_abnormal_skin_physiology0.62191386
128MP0005085_abnormal_gallbladder_physiolo0.61206450
129MP0004264_abnormal_extraembryonic_tissu0.61120218
130MP0005391_vision/eye_phenotype0.60939211
131MP0009250_abnormal_appendicular_skeleto0.60891168
132MP0001666_abnormal_nutrient_absorption0.60582428
133MP0005389_reproductive_system_phenotype0.60202672
134MP0000383_abnormal_hair_follicle0.59636428
135MP0000266_abnormal_heart_morphology0.59321797
136MP0003941_abnormal_skin_development0.59308717
137MP0002102_abnormal_ear_morphology0.58770085
138MP0002877_abnormal_melanocyte_morpholog0.58667154
139MP0002429_abnormal_blood_cell0.58355843
140MP0002751_abnormal_autonomic_nervous0.51780331
141MP0005551_abnormal_eye_electrophysiolog0.48625229
142MP0002928_abnormal_bile_duct0.47870769
143MP0003868_abnormal_feces_composition0.47418712
144MP0000678_abnormal_parathyroid_gland0.47000279
145MP0001986_abnormal_taste_sensitivity0.45957856
146MP0005646_abnormal_pituitary_gland0.45912639
147MP0000015_abnormal_ear_pigmentation0.45844265
148MP0000372_irregular_coat_pigmentation0.45554855
149MP0000377_abnormal_hair_follicle0.45092505
150MP0002090_abnormal_vision0.44382661

Predicted human phenotypes

RankGene SetZ-score
1Supernumerary spleens (HP:0009799)6.17758224
2Facial hemangioma (HP:0000329)4.76351345
3Abdominal situs inversus (HP:0003363)4.16300250
4Abnormality of abdominal situs (HP:0011620)4.16300250
5Chromsome breakage (HP:0040012)4.14793197
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.00324135
7Ependymoma (HP:0002888)3.91615393
8Lip pit (HP:0100267)3.81028801
9Septo-optic dysplasia (HP:0100842)3.75222139
10Hypoplasia of the fovea (HP:0007750)3.54920568
11Aplasia/Hypoplasia of the fovea (HP:0008060)3.54920568
12Median cleft lip (HP:0000161)3.54698022
13Cholecystitis (HP:0001082)3.52203183
14Abnormal gallbladder physiology (HP:0012438)3.52203183
15Abnormality of chromosome stability (HP:0003220)3.49743948
16Impulsivity (HP:0100710)3.48241295
17Osteomalacia (HP:0002749)3.35904867
18Medulloblastoma (HP:0002885)3.35324322
19Astrocytoma (HP:0009592)3.34439476
20Abnormality of the astrocytes (HP:0100707)3.34439476
21Absent septum pellucidum (HP:0001331)3.28714174
22Reticulocytopenia (HP:0001896)3.26877115
23Abnormality of the septum pellucidum (HP:0007375)3.24437348
24Papillary thyroid carcinoma (HP:0002895)3.19976951
25Oligodactyly (HP:0012165)3.16475431
26Volvulus (HP:0002580)3.13740980
27Rhabdomyosarcoma (HP:0002859)3.06259087
28Hypophosphatemic rickets (HP:0004912)3.04774025
29Short tibia (HP:0005736)3.03548477
30Abnormality of the fovea (HP:0000493)2.99666884
31Abnormality of the labia minora (HP:0012880)2.99038539
32Agnosia (HP:0010524)2.94731408
33Selective tooth agenesis (HP:0001592)2.92937541
34Short 4th metacarpal (HP:0010044)2.92658716
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.92658716
36Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.91403655
37Colon cancer (HP:0003003)2.89360953
38Wrist flexion contracture (HP:0001239)2.89203509
39Azoospermia (HP:0000027)2.88336035
40Cutaneous melanoma (HP:0012056)2.86630173
41Stillbirth (HP:0003826)2.83538392
42Intrahepatic cholestasis (HP:0001406)2.78698995
43Capillary hemangiomas (HP:0005306)2.78597005
44Glioma (HP:0009733)2.75714547
45Sensory axonal neuropathy (HP:0003390)2.75541623
46Sandal gap (HP:0001852)2.73388602
47Enlarged penis (HP:0000040)2.73169811
48Oral leukoplakia (HP:0002745)2.71275885
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.71034606
50Biliary tract neoplasm (HP:0100574)2.70644033
51Gonadotropin excess (HP:0000837)2.67551983
52Cortical dysplasia (HP:0002539)2.60276998
53Neoplasm of the oral cavity (HP:0100649)2.60192418
5411 pairs of ribs (HP:0000878)2.57850356
55Birth length less than 3rd percentile (HP:0003561)2.56038954
56Increased nuchal translucency (HP:0010880)2.55376942
57Abnormal spermatogenesis (HP:0008669)2.55292957
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.54557302
59Fair hair (HP:0002286)2.52518483
60Cafe-au-lait spot (HP:0000957)2.51200852
61Ankle contracture (HP:0006466)2.50031216
62Basal cell carcinoma (HP:0002671)2.48739321
63Thyroiditis (HP:0100646)2.45970496
64Posterior subcapsular cataract (HP:0007787)2.43098109
65Missing ribs (HP:0000921)2.42175913
66Poikilocytosis (HP:0004447)2.39839556
67Meckel diverticulum (HP:0002245)2.39138585
68Ulnar bowing (HP:0003031)2.38009745
69Hypochromic microcytic anemia (HP:0004840)2.37391994
70Deviation of the thumb (HP:0009603)2.37063674
71Clubbing of toes (HP:0100760)2.36712183
72Premature ovarian failure (HP:0008209)2.36226505
73Ectopic kidney (HP:0000086)2.31389969
74Neoplasm of striated muscle (HP:0009728)2.31054663
75Duodenal stenosis (HP:0100867)2.28884498
76Small intestinal stenosis (HP:0012848)2.28884498
77Proximal placement of thumb (HP:0009623)2.28546388
78Abnormality of the ileum (HP:0001549)2.28479155
79Abnormality of the preputium (HP:0100587)2.28297971
80High pitched voice (HP:0001620)2.26965732
81Heterotopia (HP:0002282)2.24086329
82Anterior segment dysgenesis (HP:0007700)2.23685801
83Prominent nose (HP:0000448)2.22618471
84Sloping forehead (HP:0000340)2.21616740
85Malignant gastrointestinal tract tumors (HP:0006749)2.21504782
86Gastrointestinal carcinoma (HP:0002672)2.21504782
87Hypopigmentation of the fundus (HP:0007894)2.21374113
88Malnutrition (HP:0004395)2.18941982
89Renovascular hypertension (HP:0100817)2.18669377
90Abnormality of the carotid arteries (HP:0005344)2.18377269
91Myelodysplasia (HP:0002863)2.17392760
92Abnormality of reticulocytes (HP:0004312)2.13244662
93Abnormality of the phalanges of the hallux (HP:0010057)2.12193745
94Aplasia/Hypoplasia of the tongue (HP:0010295)2.11304074
95Infertility (HP:0000789)2.11240433
96Horseshoe kidney (HP:0000085)2.10629187
97Abnormality of aspartate family amino acid metabolism (HP:0010899)2.10128264
98Patellar aplasia (HP:0006443)2.10105295
99Absent thumb (HP:0009777)2.10095865
100Aplasia/Hypoplasia of the macula (HP:0008059)2.10070537
101Abnormality of the 4th metacarpal (HP:0010012)2.08311349
102Amaurosis fugax (HP:0100576)2.07800119
103Abnormality of the fingertips (HP:0001211)2.06995311
104Spinal cord compression (HP:0002176)2.06599577
105Proximal tubulopathy (HP:0000114)2.05352987
106Absent radius (HP:0003974)2.04507018
107Squamous cell carcinoma (HP:0002860)2.04085254
108Hypoplasia of the capital femoral epiphysis (HP:0003090)2.01577665
109Truncal obesity (HP:0001956)2.00974760
110Hypokinesia (HP:0002375)1.98830152
111Maternal diabetes (HP:0009800)1.97123620
112Abnormality of the duodenum (HP:0002246)1.97122034
113Ovarian neoplasm (HP:0100615)1.95738134
114Spastic diplegia (HP:0001264)1.94686727
115Megaloblastic anemia (HP:0001889)1.94088245
116Male infertility (HP:0003251)1.93446507
117Neoplasm of the pancreas (HP:0002894)1.93446337
118Abnormality of chromosome segregation (HP:0002916)1.93439280
119Acanthocytosis (HP:0001927)1.92498927
120Abnormality of the labia (HP:0000058)1.92048967
121Aplastic anemia (HP:0001915)1.91545303
122Urethral obstruction (HP:0000796)1.91358341
123Aplasia/Hypoplasia affecting the retina (HP:0008061)1.89845601
124Nephroblastoma (Wilms tumor) (HP:0002667)1.89754776
125Cleft eyelid (HP:0000625)1.89408414
126Triphalangeal thumb (HP:0001199)1.89123733
127Aplasia/Hypoplasia of the patella (HP:0006498)1.88881511
128Aplasia/Hypoplasia of the earlobes (HP:0009906)1.88107662
129Absent forearm bone (HP:0003953)1.87889204
130Aplasia involving forearm bones (HP:0009822)1.87889204
131Bile duct proliferation (HP:0001408)1.85694554
132Abnormal biliary tract physiology (HP:0012439)1.85694554
133Hyperacusis (HP:0010780)1.83802807
134Short thumb (HP:0009778)1.83765986
135Duplicated collecting system (HP:0000081)1.83278302
136Bifid tongue (HP:0010297)1.83267715
137Prostate neoplasm (HP:0100787)1.82626681
138Atresia of the external auditory canal (HP:0000413)1.82534267
139Abnormal lung lobation (HP:0002101)1.82021536
140Aplasia/Hypoplasia of the sternum (HP:0006714)1.81617741
141Thyroid carcinoma (HP:0002890)1.81397027
142Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.80732779
143Bowel diverticulosis (HP:0005222)1.80692557
144Generalized aminoaciduria (HP:0002909)1.80574972
145Skull defect (HP:0001362)1.79135093
146Neoplasm of the small intestine (HP:0100833)1.78790359
147Verrucae (HP:0200043)1.78306095
148Papilloma (HP:0012740)1.78306095
149Abnormal auditory evoked potentials (HP:0006958)1.78152777
150Absent frontal sinuses (HP:0002688)1.77837690
151Breast carcinoma (HP:0003002)1.77723879
152Bicornuate uterus (HP:0000813)1.77510396
153Abnormality of cells of the erythroid lineage (HP:0012130)1.77450949
154Subacute progressive viral hepatitis (HP:0006572)1.77136049
155Cutis marmorata (HP:0000965)1.76740230
156Freckling (HP:0001480)1.75989444
157Intestinal polyposis (HP:0200008)1.75724905
158Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.75553551
159Skin pits (HP:0100276)1.75050851
160Angiofibromas (HP:0010615)1.74988444
161Adenoma sebaceum (HP:0009720)1.74988444
162Embryonal renal neoplasm (HP:0011794)1.74825447
163Abnormality of the calcaneus (HP:0008364)1.74520395
164Clitoromegaly (HP:0000057)1.73706199
165Hip contracture (HP:0003273)1.73542334
166Methylmalonic acidemia (HP:0002912)1.72488474
167Choanal atresia (HP:0000453)1.72021934
168Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.71626313
169Intestinal polyp (HP:0005266)1.71310482
170Oligodactyly (hands) (HP:0001180)1.70831045
171Esophageal atresia (HP:0002032)1.70212225

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.54691522
2ZAK6.23645182
3MAP3K95.58822025
4ARAF3.66195239
5CDC73.62231581
6VRK13.43893246
7MAP3K132.86656124
8STK42.78286124
9RPS6KA52.58335479
10PBK2.50866085
11MAP3K102.35453074
12NEK62.35450340
13BRAF2.26475527
14EEF2K2.22219803
15MST42.19039784
16NEK22.16298750
17SRPK11.92517030
18WEE11.80068779
19STK241.76746739
20SCYL21.68452571
21PKN21.66348866
22RPS6KB21.65867174
23AURKB1.65026749
24CHEK21.62853737
25CDK121.61383378
26STK161.59851036
27PIM11.57102475
28NUAK11.56954530
29BMPR1B1.52069115
30PRKCI1.51304936
31MAP3K81.48866759
32TNIK1.46363980
33BUB11.45901603
34TTK1.43542340
35MOS1.41634886
36EPHA21.33312736
37RAF11.31420330
38ATR1.24368482
39PASK1.22355668
40DAPK31.16570545
41PLK11.13527008
42PKN11.08622539
43NEK11.07865867
44TRIM281.07847718
45ACVR1B1.03867846
46DYRK31.03404750
47TIE11.02161009
48TAOK31.01144366
49TTN1.00172038
50GRK60.98647888
51PLK30.96616450
52CDK40.93731621
53NTRK20.93420280
54CHEK10.91970066
55NEK90.91575499
56AURKA0.89299449
57MELK0.85525404
58FLT30.85317834
59ATM0.84671916
60CSNK1G10.77243216
61FRK0.76465383
62FGFR20.74872916
63STK100.73701700
64EIF2AK10.73291692
65KSR20.72862053
66TSSK60.67234670
67* CDK20.67178194
68TGFBR10.64136305
69NME10.63753073
70BRSK20.62912206
71STK30.62308633
72DYRK1B0.62087285
73CDK60.61083663
74STK390.60715297
75CSNK1D0.58985925
76MARK30.58594725
77WNK30.57071331
78AKT20.55178216
79CDK70.54584144
80LATS10.53987179
81CDK80.53095913
82* CDK10.50934644
83TAF10.49835178
84EIF2AK30.49331946
85CAMK1D0.47689876
86CSNK1G30.46895233
87MAP3K120.46315862
88ALK0.44956277
89MTOR0.44349314
90VRK20.42793127
91KSR10.40928383
92OXSR10.40512773
93LRRK20.39563233
94DMPK0.39483741
95PLK40.38695490
96PRKDC0.38274690
97MAP3K40.38052433
98PRKG10.36624140
99PRKAA10.36549922
100RPS6KB10.33551564
101CSNK1A1L0.31954638
102BRSK10.31553667
103PAK40.30941491
104CLK10.30490264
105PRKACB0.30327961
106BRD40.30212608
107MAPK140.28677006
108MKNK10.27660365
109ILK0.27416248
110PDGFRA0.26979040
111PDK40.26722845
112PDK30.26722845
113CCNB10.26652162
114CSNK2A20.26066324
115ROCK10.26044058
116PTK60.25761321
117PAK10.25722010
118PAK20.24460762
119LATS20.24406589
120CSNK1G20.24347336
121CSNK2A10.23057694
122PTK20.23051939
123JAK20.22933150
124AKT10.21500030
125RPS6KA40.21238341
126FGFR30.19317856
127CAMK2A0.19287115
128TRIB30.18926310
129MKNK20.18738942
130PNCK0.17777818
131CDK190.15949220
132GSK3B0.15537642
133EIF2AK20.15438252
134FGFR10.14306881
135CSNK1E0.14146034
136RIPK10.13854541
137CSF1R0.13629656
138PRKCQ0.12630333
139RPS6KC10.12486870
140RPS6KL10.12486870
141MAPK10.12448845
142PLK20.12412892
143PIK3CG0.12400224
144RPS6KA30.11955993
145MET0.11796895
146ICK0.11675849

Predicted pathways (KEGG)

RankGene SetZ-score
1Alcoholism_Homo sapiens_hsa050346.15987107
2Viral carcinogenesis_Homo sapiens_hsa052033.26058120
3DNA replication_Homo sapiens_hsa030303.14719873
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.04061392
5Mismatch repair_Homo sapiens_hsa034302.95943146
6One carbon pool by folate_Homo sapiens_hsa006702.21345057
7Non-homologous end-joining_Homo sapiens_hsa034502.18792479
8Caffeine metabolism_Homo sapiens_hsa002322.17914841
9Cell cycle_Homo sapiens_hsa041102.15029014
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02620858
11Systemic lupus erythematosus_Homo sapiens_hsa0532210.7464779
12RNA transport_Homo sapiens_hsa030131.87338979
13Transcriptional misregulation in cancer_Homo sapiens_hsa052021.83937519
14Fanconi anemia pathway_Homo sapiens_hsa034601.80965050
15Nucleotide excision repair_Homo sapiens_hsa034201.75822983
16Homologous recombination_Homo sapiens_hsa034401.70916699
17Base excision repair_Homo sapiens_hsa034101.67884144
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65037101
19Folate biosynthesis_Homo sapiens_hsa007901.63336768
20Spliceosome_Homo sapiens_hsa030401.61672107
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54502704
22Ovarian steroidogenesis_Homo sapiens_hsa049131.37945564
23mRNA surveillance pathway_Homo sapiens_hsa030151.30043497
24Circadian rhythm_Homo sapiens_hsa047101.15911179
25Ribosome_Homo sapiens_hsa030101.13773155
26Huntingtons disease_Homo sapiens_hsa050161.12779693
27p53 signaling pathway_Homo sapiens_hsa041151.11346993
28Protein export_Homo sapiens_hsa030601.09939165
29MicroRNAs in cancer_Homo sapiens_hsa052061.04973805
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00807737
31Oxidative phosphorylation_Homo sapiens_hsa001900.92716544
32Parkinsons disease_Homo sapiens_hsa050120.89354284
33Selenocompound metabolism_Homo sapiens_hsa004500.85489285
34RNA degradation_Homo sapiens_hsa030180.84747112
35Pyrimidine metabolism_Homo sapiens_hsa002400.83130274
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82723603
37Olfactory transduction_Homo sapiens_hsa047400.77992712
38Oocyte meiosis_Homo sapiens_hsa041140.77844096
39Small cell lung cancer_Homo sapiens_hsa052220.73633274
40RNA polymerase_Homo sapiens_hsa030200.70616694
41Gap junction_Homo sapiens_hsa045400.70543552
42HTLV-I infection_Homo sapiens_hsa051660.70474026
43Dorso-ventral axis formation_Homo sapiens_hsa043200.69319611
44Propanoate metabolism_Homo sapiens_hsa006400.68877205
45Vitamin digestion and absorption_Homo sapiens_hsa049770.68000661
46Fatty acid elongation_Homo sapiens_hsa000620.67328616
47Basal transcription factors_Homo sapiens_hsa030220.65697481
48Chronic myeloid leukemia_Homo sapiens_hsa052200.63928375
49mTOR signaling pathway_Homo sapiens_hsa041500.60616519
50Non-small cell lung cancer_Homo sapiens_hsa052230.59142525
51Epstein-Barr virus infection_Homo sapiens_hsa051690.58281953
52Pyruvate metabolism_Homo sapiens_hsa006200.56736334
53Lysine degradation_Homo sapiens_hsa003100.56269586
54Antigen processing and presentation_Homo sapiens_hsa046120.55603469
55Colorectal cancer_Homo sapiens_hsa052100.52596148
56Sulfur metabolism_Homo sapiens_hsa009200.52518497
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52321233
58Herpes simplex infection_Homo sapiens_hsa051680.50377593
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49828229
60Glutathione metabolism_Homo sapiens_hsa004800.44980142
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.44169949
62TGF-beta signaling pathway_Homo sapiens_hsa043500.44097689
63Bladder cancer_Homo sapiens_hsa052190.41924515
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40970412
65Biosynthesis of amino acids_Homo sapiens_hsa012300.40630241
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40491755
67Phototransduction_Homo sapiens_hsa047440.40252899
68Nicotine addiction_Homo sapiens_hsa050330.40232983
69Alzheimers disease_Homo sapiens_hsa050100.38782658
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38438628
71Hippo signaling pathway_Homo sapiens_hsa043900.38250448
72Regulation of autophagy_Homo sapiens_hsa041400.38226337
73Glioma_Homo sapiens_hsa052140.37680646
74B cell receptor signaling pathway_Homo sapiens_hsa046620.36741196
75Prostate cancer_Homo sapiens_hsa052150.35547398
76Pentose phosphate pathway_Homo sapiens_hsa000300.35164496
77Purine metabolism_Homo sapiens_hsa002300.34127172
78Pancreatic cancer_Homo sapiens_hsa052120.34002311
79Apoptosis_Homo sapiens_hsa042100.33657844
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.32516697
81FoxO signaling pathway_Homo sapiens_hsa040680.32329025
82Hepatitis B_Homo sapiens_hsa051610.32308229
83Basal cell carcinoma_Homo sapiens_hsa052170.30967403
84Proteoglycans in cancer_Homo sapiens_hsa052050.30736192
85Metabolic pathways_Homo sapiens_hsa011000.29295272
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28904763
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28534350
88Adherens junction_Homo sapiens_hsa045200.28254075
89Thyroid cancer_Homo sapiens_hsa052160.28230486
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27049503
91Chemical carcinogenesis_Homo sapiens_hsa052040.26288906
92Endometrial cancer_Homo sapiens_hsa052130.26242271
93Melanoma_Homo sapiens_hsa052180.25864174
94Steroid biosynthesis_Homo sapiens_hsa001000.25470449
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25415629
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25208276
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.24404207
98Pathways in cancer_Homo sapiens_hsa052000.24103719
99Tight junction_Homo sapiens_hsa045300.23931914
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23550435
101Inositol phosphate metabolism_Homo sapiens_hsa005620.23145992
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23044127
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22980820
104Primary immunodeficiency_Homo sapiens_hsa053400.22295090
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.22242823
106Vitamin B6 metabolism_Homo sapiens_hsa007500.21513475
107Notch signaling pathway_Homo sapiens_hsa043300.21382786
108HIF-1 signaling pathway_Homo sapiens_hsa040660.21347255
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19415153
110Cardiac muscle contraction_Homo sapiens_hsa042600.18734785
111Legionellosis_Homo sapiens_hsa051340.17892929
112Synaptic vesicle cycle_Homo sapiens_hsa047210.17854772
113Renin-angiotensin system_Homo sapiens_hsa046140.17272770
114Viral myocarditis_Homo sapiens_hsa054160.15618378
115Focal adhesion_Homo sapiens_hsa045100.15500215
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15170698
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.15044387
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.14854749
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.14785048
120AMPK signaling pathway_Homo sapiens_hsa041520.14515556
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14506118
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.14241446
123Retinol metabolism_Homo sapiens_hsa008300.13892605
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13486740
125Arginine and proline metabolism_Homo sapiens_hsa003300.13381366
126Taste transduction_Homo sapiens_hsa047420.12863834
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12400988
128Measles_Homo sapiens_hsa051620.11890915
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.11620840
130Influenza A_Homo sapiens_hsa051640.11599321
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.10963121
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.10801118
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10704200
134Glucagon signaling pathway_Homo sapiens_hsa049220.09830061
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08960191
136Platelet activation_Homo sapiens_hsa046110.08726777
137Hematopoietic cell lineage_Homo sapiens_hsa046400.08289574
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.08100230
139Proteasome_Homo sapiens_hsa030500.07884173
140Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.07796605
141Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.07595646
142Wnt signaling pathway_Homo sapiens_hsa043100.07392194
143ABC transporters_Homo sapiens_hsa020100.06844958
144Carbon metabolism_Homo sapiens_hsa012000.06393454
145Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.05580136
146Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.04679971
147Hedgehog signaling pathway_Homo sapiens_hsa043400.04456254
148Mineral absorption_Homo sapiens_hsa049780.03848108

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