HIST1H1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome organization (GO:0034723)8.13827155
2DNA replication-dependent nucleosome assembly (GO:0006335)8.13827155
3mucosal immune response (GO:0002385)7.28446580
4chromatin assembly (GO:0031497)6.93457946
5organ or tissue specific immune response (GO:0002251)6.57251150
6DNA unwinding involved in DNA replication (GO:0006268)6.04828723
7* nucleosome assembly (GO:0006334)5.77730130
8nuclear pore complex assembly (GO:0051292)5.61164738
9protein localization to kinetochore (GO:0034501)5.59857507
10chromatin assembly or disassembly (GO:0006333)5.55631901
11nuclear pore organization (GO:0006999)5.52452790
12mitotic chromosome condensation (GO:0007076)5.46140977
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.16687501
14* nucleosome organization (GO:0034728)5.03652663
15* protein-DNA complex assembly (GO:0065004)4.97539106
16protein localization to chromosome, centromeric region (GO:0071459)4.91351048
17chromatin remodeling at centromere (GO:0031055)4.90384002
18sister chromatid segregation (GO:0000819)4.89712542
19CENP-A containing nucleosome assembly (GO:0034080)4.84836557
20DNA replication initiation (GO:0006270)4.65991592
21V(D)J recombination (GO:0033151)4.65506901
22DNA strand elongation involved in DNA replication (GO:0006271)4.61350936
23kinetochore organization (GO:0051383)4.61180734
24* protein-DNA complex subunit organization (GO:0071824)4.48040323
25telomere maintenance via semi-conservative replication (GO:0032201)4.44974128
26mitotic recombination (GO:0006312)4.40975141
27mitotic sister chromatid segregation (GO:0000070)4.40725566
28DNA strand elongation (GO:0022616)4.36617144
29pore complex assembly (GO:0046931)4.35396503
30DNA replication-independent nucleosome assembly (GO:0006336)4.31553334
31DNA replication-independent nucleosome organization (GO:0034724)4.31553334
32double-strand break repair via nonhomologous end joining (GO:0006303)4.28684692
33non-recombinational repair (GO:0000726)4.28684692
34folic acid-containing compound biosynthetic process (GO:0009396)4.22412240
35* regulation of histone H3-K9 methylation (GO:0051570)4.21103767
36DNA geometric change (GO:0032392)4.15502461
37antibacterial humoral response (GO:0019731)4.15146606
38DNA duplex unwinding (GO:0032508)4.14752500
39telomere maintenance via recombination (GO:0000722)4.12340322
40mitotic nuclear envelope disassembly (GO:0007077)4.11381276
41ribosomal small subunit assembly (GO:0000028)4.11004624
42DNA ligation (GO:0006266)4.07869307
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.02870506
44histone exchange (GO:0043486)3.96824642
45mitotic sister chromatid cohesion (GO:0007064)3.94057560
46positive regulation of chromosome segregation (GO:0051984)3.89426827
47nuclear envelope disassembly (GO:0051081)3.87924787
48membrane disassembly (GO:0030397)3.87924787
49antimicrobial humoral response (GO:0019730)3.87693507
50positive regulation of mitotic sister chromatid separation (GO:1901970)3.85887527
51positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.85887527
52positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.85887527
53innate immune response in mucosa (GO:0002227)3.85270358
54negative regulation of histone methylation (GO:0031061)3.84279884
55DNA topological change (GO:0006265)3.83847395
56mitotic metaphase plate congression (GO:0007080)3.83111437
57IMP biosynthetic process (GO:0006188)3.82765775
58viral transcription (GO:0019083)3.81802787
59attachment of spindle microtubules to kinetochore (GO:0008608)3.79570205
60protein K6-linked ubiquitination (GO:0085020)3.75177647
61translational termination (GO:0006415)3.73528245
62chromosome condensation (GO:0030261)3.73451503
63nucleotide-excision repair, DNA gap filling (GO:0006297)3.70983924
64translesion synthesis (GO:0019985)3.69646863
65regulation of sister chromatid cohesion (GO:0007063)3.67812084
66regulation of centriole replication (GO:0046599)3.67557445
67metaphase plate congression (GO:0051310)3.65303441
68regulation of DNA endoreduplication (GO:0032875)3.63906776
69negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.63539980
70somatic cell DNA recombination (GO:0016444)3.63288127
71somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.63288127
72regulation of centrosome cycle (GO:0046605)3.62271107
73regulation of gene silencing (GO:0060968)3.61041778
74meiotic chromosome segregation (GO:0045132)3.56085764
75DNA replication checkpoint (GO:0000076)3.53896108
76negative regulation of chromosome segregation (GO:0051985)3.52531576
77kinetochore assembly (GO:0051382)3.52101580
78regulation of spindle organization (GO:0090224)3.52081422
79DNA conformation change (GO:0071103)3.48546804
80telomere maintenance via telomere lengthening (GO:0010833)3.47518302
81regulation of mitotic sister chromatid separation (GO:0010965)3.44959586
82regulation of mitotic sister chromatid segregation (GO:0033047)3.44959586
83regulation of sister chromatid segregation (GO:0033045)3.44959586
84negative regulation of DNA repair (GO:0045738)3.43995183
85telomere maintenance (GO:0000723)3.43747080
86dosage compensation (GO:0007549)3.41589048
87IMP metabolic process (GO:0046040)3.41471683
88regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.41228820
89telomere organization (GO:0032200)3.39827390
90ATP-dependent chromatin remodeling (GO:0043044)3.38575859
91postreplication repair (GO:0006301)3.38365770
92protein localization to chromosome (GO:0034502)3.38044114
93negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.36368211
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.36368211
95negative regulation of mitotic sister chromatid segregation (GO:0033048)3.36368211
96negative regulation of mitotic sister chromatid separation (GO:2000816)3.36368211
97negative regulation of sister chromatid segregation (GO:0033046)3.36368211
98establishment of chromosome localization (GO:0051303)3.36100221
99maturation of SSU-rRNA (GO:0030490)3.34986950
100somatic diversification of immune receptors (GO:0002200)3.34091287
101regulation of chromosome segregation (GO:0051983)3.33443637
102maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.33100997
103regulation of helicase activity (GO:0051095)3.30808579
104translational elongation (GO:0006414)3.29251771
105nucleobase biosynthetic process (GO:0046112)3.28202074
106ribosomal small subunit biogenesis (GO:0042274)3.28160547
107mitotic spindle assembly checkpoint (GO:0007094)3.27227012
108spindle checkpoint (GO:0031577)3.26545846
109regulation of mitotic spindle organization (GO:0060236)3.26011234
110DNA packaging (GO:0006323)3.25408167
111chromosome segregation (GO:0007059)3.25232786
112DNA synthesis involved in DNA repair (GO:0000731)3.24939921
113spindle assembly checkpoint (GO:0071173)3.24571657
114regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23526296
115regulation of mitotic metaphase/anaphase transition (GO:0030071)3.22457564
116regulation of centrosome duplication (GO:0010824)3.21064184
117somatic diversification of immune receptors via somatic mutation (GO:0002566)3.19498378
118somatic hypermutation of immunoglobulin genes (GO:0016446)3.19498378
119regulation of gene silencing by RNA (GO:0060966)3.18804224
120regulation of posttranscriptional gene silencing (GO:0060147)3.18804224
121regulation of gene silencing by miRNA (GO:0060964)3.18804224
122nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.18635046
123regulation of RNA export from nucleus (GO:0046831)3.17506721
124mitotic spindle checkpoint (GO:0071174)3.15712158
125regulation of megakaryocyte differentiation (GO:0045652)3.15302509
126ribosomal large subunit biogenesis (GO:0042273)3.14538092
127somatic recombination of immunoglobulin gene segments (GO:0016447)3.13615086
128viral mRNA export from host cell nucleus (GO:0046784)3.07701458

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.21217997
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.94767148
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.52948614
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.44910487
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.17921453
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.88151684
7* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.62216678
8* MYC_18555785_ChIP-Seq_MESCs_Mouse2.52011653
9GATA1_22025678_ChIP-Seq_K562_Human2.40858877
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.34254288
11* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.32700210
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.32215899
13* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06785010
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.00157376
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse13.7879610
16* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96509068
17MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89170399
18* SOX2_16153702_ChIP-ChIP_HESCs_Human1.78190069
19AR_21909140_ChIP-Seq_LNCAP_Human1.75327226
20EGR1_19374776_ChIP-ChIP_THP-1_Human1.73170675
21* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.69327656
22ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65690113
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64287091
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60421663
25IRF1_19129219_ChIP-ChIP_H3396_Human1.56531480
26* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56452035
27SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.54753056
28VDR_23849224_ChIP-Seq_CD4+_Human1.53185368
29* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.44877728
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44650250
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44480668
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43991176
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40971044
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39624726
35* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.39362550
36ELK1_19687146_ChIP-ChIP_HELA_Human1.33721935
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.33052136
38ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30907959
39* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30575762
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30549441
41* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28350047
42XRN2_22483619_ChIP-Seq_HELA_Human1.28296379
43* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26620870
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26374981
45HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24121985
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23982749
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.21378708
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19317933
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19221732
50* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19116671
51FOXP3_21729870_ChIP-Seq_TREG_Human1.17891811
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17783543
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15034541
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11465423
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11436926
56* NANOG_16153702_ChIP-ChIP_HESCs_Human1.09325402
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08330667
58MYC_22102868_ChIP-Seq_BL_Human1.07705437
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06769301
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06306632
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.04480723
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01914424
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00894081
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00844526
65* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.99283628
66* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.98828548
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98354327
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96476023
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95406643
70RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95259956
71* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95173921
72GABP_17652178_ChIP-ChIP_JURKAT_Human0.93204930
73* THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92805241
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92270905
75HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91967896
76TTF2_22483619_ChIP-Seq_HELA_Human0.89874379
77CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86686880
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85905165
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84292095
80CIITA_25753668_ChIP-Seq_RAJI_Human0.84044364
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83162470
82VDR_21846776_ChIP-Seq_THP-1_Human0.81960937
83KDM5A_27292631_Chip-Seq_BREAST_Human0.80658704
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.80588744
85STAT4_19710469_ChIP-ChIP_TH1__Mouse0.80135062
86DCP1A_22483619_ChIP-Seq_HELA_Human0.79943161
87MYC_18940864_ChIP-ChIP_HL60_Human0.77913224
88BRD4_27068464_Chip-Seq_AML-cells_Mouse0.77117126
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76939136
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.75938667
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.75730207
92JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.72850438
93* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.72315774
94ELF1_17652178_ChIP-ChIP_JURKAT_Human0.69631185
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.69157823
96MAF_26560356_Chip-Seq_TH1_Human0.68889818
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.67451945
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.67244761
99FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.66282570
100TP63_19390658_ChIP-ChIP_HaCaT_Human0.66085554
101GABP_19822575_ChIP-Seq_HepG2_Human0.65685327
102* SALL4_22934838_ChIP-ChIP_CD34+_Human0.65520241
103KLF4_18555785_ChIP-Seq_MESCs_Mouse0.64980139
104* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.64533415
105* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.63941812
106* MYB_26560356_Chip-Seq_TH1_Human0.61097179
107* NANOG_21062744_ChIP-ChIP_HESCs_Human0.60524864
108* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.60228485
109* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.60227028
110NOTCH1_21737748_ChIP-Seq_TLL_Human0.58632623
111SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.57459131
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.55445952
113SOX17_20123909_ChIP-Seq_XEN_Mouse0.52695602
114SOX9_26525672_Chip-Seq_HEART_Mouse0.51478947
115PKCTHETA_26484144_Chip-Seq_BREAST_Human0.50421395
116MYB_26560356_Chip-Seq_TH2_Human0.50170378

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.29281523
2MP0003693_abnormal_embryo_hatching4.53173668
3MP0003111_abnormal_nucleus_morphology4.47601300
4MP0003077_abnormal_cell_cycle4.02247258
5MP0004957_abnormal_blastocyst_morpholog3.75248874
6MP0008057_abnormal_DNA_replication3.72089290
7MP0010307_abnormal_tumor_latency3.53739533
8MP0008058_abnormal_DNA_repair2.88481836
9MP0010352_gastrointestinal_tract_polyps2.88175653
10MP0003123_paternal_imprinting2.62948753
11MP0008932_abnormal_embryonic_tissue2.49136263
12MP0003763_abnormal_thymus_physiology2.42690594
13MP0009697_abnormal_copulation2.41371315
14MP0000350_abnormal_cell_proliferation2.33343300
15MP0008007_abnormal_cellular_replicative2.26248949
16MP0001730_embryonic_growth_arrest2.25634091
17MP0003705_abnormal_hypodermis_morpholog2.22475636
18MP0005076_abnormal_cell_differentiation2.14783605
19MP0010234_abnormal_vibrissa_follicle2.13471718
20MP0003121_genomic_imprinting2.12603144
21MP0002396_abnormal_hematopoietic_system2.10325044
22MP0008877_abnormal_DNA_methylation2.00529535
23MP0000685_abnormal_immune_system1.94821295
24MP0006054_spinal_hemorrhage1.90252386
25MP0004197_abnormal_fetal_growth/weight/1.79510507
26MP0004808_abnormal_hematopoietic_stem1.78355927
27MP0001697_abnormal_embryo_size1.73930889
28MP0001661_extended_life_span1.71737798
29MP0005380_embryogenesis_phenotype1.70542070
30MP0001672_abnormal_embryogenesis/_devel1.70542070
31MP0002086_abnormal_extraembryonic_tissu1.68820286
32MP0002084_abnormal_developmental_patter1.65924512
33MP0002085_abnormal_embryonic_tissue1.64709564
34MP0002080_prenatal_lethality1.58418600
35MP0000490_abnormal_crypts_of1.56791390
36MP0005645_abnormal_hypothalamus_physiol1.51760573
37MP0002019_abnormal_tumor_incidence1.50683829
38MP0003984_embryonic_growth_retardation1.48805434
39MP0003656_abnormal_erythrocyte_physiolo1.47508120
40MP0002088_abnormal_embryonic_growth/wei1.46950318
41MP0001835_abnormal_antigen_presentation1.43446495
42MP0005083_abnormal_biliary_tract1.42492151
43MP0000537_abnormal_urethra_morphology1.42191108
44MP0004147_increased_porphyrin_level1.38085603
45MP0000313_abnormal_cell_death1.36960714
46MP0001293_anophthalmia1.34871670
47MP0003786_premature_aging1.33936372
48MP0003937_abnormal_limbs/digits/tail_de1.30727023
49MP0003890_abnormal_embryonic-extraembry1.30550549
50MP0000703_abnormal_thymus_morphology1.27556549
51MP0002009_preneoplasia1.23690510
52MP0003787_abnormal_imprinting1.14500106
53MP0002166_altered_tumor_susceptibility1.10653032
54MP0005220_abnormal_exocrine_pancreas1.08275343
55MP0003567_abnormal_fetal_cardiomyocyte1.06759906
56MP0002398_abnormal_bone_marrow1.05098469
57MP0002722_abnormal_immune_system1.04747708
58MP0002111_abnormal_tail_morphology1.03317558
59MP0002092_abnormal_eye_morphology1.01587932
60MP0005671_abnormal_response_to1.00672518
61MP0004185_abnormal_adipocyte_glucose0.99912353
62MP0002006_tumorigenesis0.98858386
63MP0000733_abnormal_muscle_development0.97997724
64MP0002697_abnormal_eye_size0.97736136
65MP0009703_decreased_birth_body0.97257793
66MP0009053_abnormal_anal_canal0.95129634
67MP0000689_abnormal_spleen_morphology0.94394217
68MP0001915_intracranial_hemorrhage0.93715434
69MP0003566_abnormal_cell_adhesion0.93635542
70MP0010030_abnormal_orbit_morphology0.93579039
71MP0003941_abnormal_skin_development0.86571063
72MP0001545_abnormal_hematopoietic_system0.86275069
73MP0005397_hematopoietic_system_phenotyp0.86275069
74MP0005075_abnormal_melanosome_morpholog0.85146201
75MP0003806_abnormal_nucleotide_metabolis0.85121238
76MP0006035_abnormal_mitochondrial_morpho0.85053662
77MP0009672_abnormal_birth_weight0.84212100
78MP0010678_abnormal_skin_adnexa0.83558111
79MP0004381_abnormal_hair_follicle0.82321806
80MP0001286_abnormal_eye_development0.82297217
81MP0005621_abnormal_cell_physiology0.81088655
82MP0000015_abnormal_ear_pigmentation0.80245248
83MP0005384_cellular_phenotype0.79688466
84MP0008770_decreased_survivor_rate0.79554598
85MP0005310_abnormal_salivary_gland0.77205882
86MP0002210_abnormal_sex_determination0.76965438
87MP0001790_abnormal_immune_system0.76657921
88MP0005387_immune_system_phenotype0.76657921
89MP0000428_abnormal_craniofacial_morphol0.74748189
90MP0003119_abnormal_digestive_system0.74727206
91MP0002429_abnormal_blood_cell0.74329386
92MP0003718_maternal_effect0.72888239
93MP0005023_abnormal_wound_healing0.72849278
94MP0001145_abnormal_male_reproductive0.71401178
95MP0002420_abnormal_adaptive_immunity0.70771856
96MP0002925_abnormal_cardiovascular_devel0.70270133
97MP0005501_abnormal_skin_physiology0.70037269
98MP0003448_altered_tumor_morphology0.69500646
99MP0002877_abnormal_melanocyte_morpholog0.69328622
100MP0002095_abnormal_skin_pigmentation0.69134527
101MP0000432_abnormal_head_morphology0.69022052
102MP0005647_abnormal_sex_gland0.68489992
103MP0003935_abnormal_craniofacial_develop0.68173645
104MP0001191_abnormal_skin_condition0.67366228
105MP0001819_abnormal_immune_cell0.66818285
106MP0003861_abnormal_nervous_system0.64490553
107MP0002452_abnormal_antigen_presenting0.63686896
108MP0005000_abnormal_immune_tolerance0.62745083
109MP0000477_abnormal_intestine_morphology0.62434387
110MP0001929_abnormal_gametogenesis0.61862649
111MP0002163_abnormal_gland_morphology0.61817410
112MP0009931_abnormal_skin_appearance0.61613069
113MP0001119_abnormal_female_reproductive0.61249949
114MP0000653_abnormal_sex_gland0.60283528
115MP0003115_abnormal_respiratory_system0.60229322
116MP0000569_abnormal_digit_pigmentation0.59706275
117MP0001727_abnormal_embryo_implantation0.59570106
118MP0000383_abnormal_hair_follicle0.59221269
119MP0003699_abnormal_female_reproductive0.58668277
120MP0002075_abnormal_coat/hair_pigmentati0.58185157
121MP0003300_gastrointestinal_ulcer0.57857902
122MP0006072_abnormal_retinal_apoptosis0.57670472
123MP0002638_abnormal_pupillary_reflex0.57318619
124MP0000716_abnormal_immune_system0.57058116
125MP0008438_abnormal_cutaneous_collagen0.56634831
126MP0001849_ear_inflammation0.56390379
127MP0001800_abnormal_humoral_immune0.56078941
128MP0009278_abnormal_bone_marrow0.55949362
129MP0000358_abnormal_cell_content/0.55840851

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)5.81448344
2IgA deficiency (HP:0002720)5.19339533
3Chromsome breakage (HP:0040012)4.68413620
4Reticulocytopenia (HP:0001896)4.61652683
5Colitis (HP:0002583)4.52724589
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.41247724
7B lymphocytopenia (HP:0010976)3.98866132
8Abnormality of chromosome stability (HP:0003220)3.81286775
9Agammaglobulinemia (HP:0004432)3.57535132
10Abnormality of B cell number (HP:0010975)3.40024992
11Gastrointestinal stroma tumor (HP:0100723)3.37624458
12Medulloblastoma (HP:0002885)3.35183586
13Abnormality of cells of the erythroid lineage (HP:0012130)3.34705818
14Colon cancer (HP:0003003)3.32085720
15Cellulitis (HP:0100658)3.27698060
16Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.26837812
17Short 4th metacarpal (HP:0010044)3.26837812
18Ependymoma (HP:0002888)3.23361666
19Birth length less than 3rd percentile (HP:0003561)3.19318325
20Impulsivity (HP:0100710)3.17190158
21Volvulus (HP:0002580)3.09334877
22Abnormal number of erythroid precursors (HP:0012131)3.06492617
23Selective tooth agenesis (HP:0001592)3.05152014
24Poikilocytosis (HP:0004447)2.98841249
25Recurrent sinusitis (HP:0011108)2.98580231
26Agnosia (HP:0010524)2.95226692
27Meckel diverticulum (HP:0002245)2.88080478
28Abnormality of the labia minora (HP:0012880)2.86710980
29Rhabdomyosarcoma (HP:0002859)2.82581436
30Aplasia/Hypoplasia of the uvula (HP:0010293)2.80816060
31Abnormality of reticulocytes (HP:0004312)2.74293477
32Abnormality of the ileum (HP:0001549)2.72788893
33Abnormality of the preputium (HP:0100587)2.71789165
34Astrocytoma (HP:0009592)2.66894169
35Abnormality of the astrocytes (HP:0100707)2.66894169
36Lymphopenia (HP:0001888)2.65248698
37Duodenal stenosis (HP:0100867)2.64631484
38Small intestinal stenosis (HP:0012848)2.64631484
39Recurrent viral infections (HP:0004429)2.62830326
40Cutaneous melanoma (HP:0012056)2.61226324
41Hypochromic microcytic anemia (HP:0004840)2.58571806
42Increased nuchal translucency (HP:0010880)2.57716963
43Abnormality of cells of the lymphoid lineage (HP:0012140)2.55752983
44Myelodysplasia (HP:0002863)2.54332386
45Basal cell carcinoma (HP:0002671)2.50382925
46Inflammation of the large intestine (HP:0002037)2.50177513
4711 pairs of ribs (HP:0000878)2.49037698
48Cafe-au-lait spot (HP:0000957)2.48190997
49Panhypogammaglobulinemia (HP:0003139)2.46501429
50High pitched voice (HP:0001620)2.46289759
51Combined immunodeficiency (HP:0005387)2.43608352
52Sandal gap (HP:0001852)2.43350153
53Macrocytic anemia (HP:0001972)2.42576616
54Absent thumb (HP:0009777)2.42472547
55Duplicated collecting system (HP:0000081)2.42210201
56Pallor (HP:0000980)2.38514522
57Glioma (HP:0009733)2.38131214
58Ectopic kidney (HP:0000086)2.37965500
59Sloping forehead (HP:0000340)2.36091329
60Autoimmune hemolytic anemia (HP:0001890)2.35430282
61Recurrent bronchitis (HP:0002837)2.35301991
62Missing ribs (HP:0000921)2.33692297
63Biliary tract neoplasm (HP:0100574)2.32910173
64Patellar aplasia (HP:0006443)2.32508213
65Gastrointestinal inflammation (HP:0004386)2.32253878
66Absent radius (HP:0003974)2.31118909
67Microvesicular hepatic steatosis (HP:0001414)2.30117178
68Prominent nose (HP:0000448)2.28017498
69Abnormality of the carotid arteries (HP:0005344)2.26724305
70Deviation of the thumb (HP:0009603)2.26718515
71Abnormality of the duodenum (HP:0002246)2.21985128
72Abnormality of the 4th metacarpal (HP:0010012)2.21467432
73Proximal placement of thumb (HP:0009623)2.20215357
74Abnormal number of incisors (HP:0011064)2.20159214
75Neoplasm of the oral cavity (HP:0100649)2.17286445
76Prostate neoplasm (HP:0100787)2.16007732
77Acanthocytosis (HP:0001927)2.15023049
78Cortical dysplasia (HP:0002539)2.14063953
79Absent forearm bone (HP:0003953)2.12511494
80Aplasia involving forearm bones (HP:0009822)2.12511494
81Leukopenia (HP:0001882)2.12187308
82Squamous cell carcinoma (HP:0002860)2.11716249
83Aplasia/Hypoplasia of the patella (HP:0006498)2.11196240
84Arteriovenous malformation (HP:0100026)2.09937979
85Abnormal lung lobation (HP:0002101)2.09629047
86Atresia of the external auditory canal (HP:0000413)2.08934290
87Neoplasm of striated muscle (HP:0009728)2.06875631
88Carpal bone hypoplasia (HP:0001498)2.06811969
89Spastic diplegia (HP:0001264)2.04929442
90Embryonal neoplasm (HP:0002898)2.04824519
91Orthostatic hypotension (HP:0001278)2.04676259
92Osteomyelitis (HP:0002754)2.04038686
93Neoplasm of the pancreas (HP:0002894)2.03902905
94Abnormality of the heme biosynthetic pathway (HP:0010472)2.03301062
95Severe combined immunodeficiency (HP:0004430)2.01892251
96Abnormality of the renal collecting system (HP:0004742)2.01563311
97Skull defect (HP:0001362)2.00944256
98Deep philtrum (HP:0002002)2.00874793
99Breast hypoplasia (HP:0003187)1.99956262
100Nephroblastoma (Wilms tumor) (HP:0002667)1.99318625
101Short thumb (HP:0009778)1.99073320
102Amaurosis fugax (HP:0100576)1.98791146
103Malignant gastrointestinal tract tumors (HP:0006749)1.98247458
104Gastrointestinal carcinoma (HP:0002672)1.98247458
105Thrombocytosis (HP:0001894)1.95556391
106Dry hair (HP:0011359)1.93401784
107Abnormality of the fingertips (HP:0001211)1.93142690
108Viral hepatitis (HP:0006562)1.92497415
109Absent frontal sinuses (HP:0002688)1.92294480
110Chronic diarrhea (HP:0002028)1.92097673
111Abnormality of the prostate (HP:0008775)1.90794967
112Neoplasm of the adrenal cortex (HP:0100641)1.88215483
113Abnormality of the calcaneus (HP:0008364)1.87430466
114Thyroiditis (HP:0100646)1.85993213
115Embryonal renal neoplasm (HP:0011794)1.84777623
116Ovarian neoplasm (HP:0100615)1.84147136
117Aplasia/Hypoplasia of the sternum (HP:0006714)1.83721557
118Tracheoesophageal fistula (HP:0002575)1.83430120
119Meningitis (HP:0001287)1.83318308
120Ulnar bowing (HP:0003031)1.82931187
121Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.82304598
122Asymmetry of the thorax (HP:0001555)1.82109833
123Abnormality of abdominal situs (HP:0011620)1.81076604
124Abdominal situs inversus (HP:0003363)1.81076604
125Acute lymphatic leukemia (HP:0006721)1.80929211
126Aplasia/Hypoplasia of the earlobes (HP:0009906)1.80922662
127Clubbing of toes (HP:0100760)1.80425138
128Hepatitis (HP:0012115)1.79156765
129Abnormality of pyrimidine metabolism (HP:0004353)1.79026357
130Microtia (HP:0008551)1.78876154
131Poikiloderma (HP:0001029)1.78581402
132Abnormality of chromosome segregation (HP:0002916)1.78448915
133IgG deficiency (HP:0004315)1.77219566
134Lymphoma (HP:0002665)1.77129678
135Bone marrow hypocellularity (HP:0005528)1.76482169
136Insomnia (HP:0100785)1.76444679
137Neoplasm of the colon (HP:0100273)1.75888141
138Abnormality of DNA repair (HP:0003254)1.75581184
139Acute myeloid leukemia (HP:0004808)1.75028995
140Freckling (HP:0001480)1.74627933
141Cellular immunodeficiency (HP:0005374)1.74493985
142Renovascular hypertension (HP:0100817)1.72662354
143Aplasia/Hypoplasia of the sacrum (HP:0008517)1.71392696
144Reticulocytosis (HP:0001923)1.70549689

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK18.75172758
2ZAK5.59364155
3CDC73.93085914
4VRK13.39757955
5STK42.91903567
6RPS6KA52.61171881
7MAP3K102.39518964
8NEK22.28255459
9SRPK12.20844149
10WEE12.18261519
11BUB12.10202806
12SCYL22.04129564
13AURKB1.89770441
14CDK91.88488056
15EEF2K1.84788118
16CHEK21.67023861
17RPS6KB21.63848775
18TTK1.59265913
19SMG11.56259292
20MAP3K81.55155606
21TAF11.53563461
22PKN21.49005994
23PIM11.45284630
24CDK121.39124163
25EIF2AK11.36227765
26ATR1.35076858
27ACVR1B1.31600686
28PLK11.31503781
29NEK11.26734676
30DYRK31.26186068
31DAPK31.19149325
32CDK41.11101413
33NME21.06367611
34BRSK21.04384757
35TTN1.04181982
36AURKA1.02978473
37PLK30.99080598
38PASK0.97527624
39CHEK10.95859824
40STK100.94006446
41CCNB10.91936582
42FLT30.90322663
43ATM0.86149366
44EPHA20.84858167
45CDK60.83607723
46RPS6KA40.82880281
47PKN10.82281780
48MELK0.78112628
49BTK0.75967175
50CDK70.74888667
51* CDK20.70976996
52PLK40.70148866
53MKNK10.64539162
54EIF2AK30.63925886
55PRPF4B0.61646748
56TSSK60.60984852
57CDK10.60179585
58BRSK10.59968644
59TGFBR10.58314003
60LRRK20.57039390
61GRK60.56934176
62DYRK1B0.55881172
63FRK0.54171023
64CAMK1D0.54111724
65AKT20.52479157
66BRAF0.52294674
67NEK90.50263942
68MKNK20.48479453
69CSNK1D0.48235809
70STK30.47332537
71CDK80.46207826
72NLK0.46120510
73SYK0.45706853
74TESK20.43866917
75ALK0.43224063
76PAK40.42023280
77EIF2AK20.40679510
78MAPK110.39380760
79PRKDC0.38130073
80CLK10.37955821
81FGFR20.37623291
82PIK3CG0.37081288
83ICK0.36346626
84LATS10.36282932
85MST40.36226259
86NUAK10.35741243
87PRKCQ0.34831546
88CSNK2A20.34794381
89BRD40.33296230
90PAK10.33217731
91TEC0.32113039
92VRK20.31254979
93MTOR0.29724680
94PRKAA10.24220590
95MAP3K40.22358132
96MAPKAPK50.22132850
97BLK0.22103046
98AKT10.22096722
99RPS6KB10.22035700
100LYN0.21796084
101* MAPK140.21194812
102CSF1R0.21165004
103IRAK40.19101509
104CSNK2A10.18853196
105RAF10.17899537
106ILK0.17414931
107JAK20.17314152
108ROCK10.16837462
109FGFR10.16500267
110PAK20.16449573
111CSNK1G10.16153849
112RPS6KC10.15511352
113RPS6KL10.15511352
114PTK60.15281924
115BMPR1B0.14845293
116PDGFRA0.13815262
117MAPKAPK30.13459548
118MAP2K70.12996933
119TRPM70.12881518
120CAMK40.12640227
121CSNK1E0.12467674
122CSNK1G30.11629525
123PBK0.11232147
124RPS6KA10.10904638
125RPS6KA30.10819369
126PRKCI0.10724937
127MAP4K10.10595143
128CDK150.09821801
129STK240.09208440
130MAPK10.09118911
131FGR0.08850599
132PIM20.08501232
133SGK10.07672179
134MAPK90.06891271

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053229.87503089
2Alcoholism_Homo sapiens_hsa050345.55970699
3DNA replication_Homo sapiens_hsa030303.96853570
4Mismatch repair_Homo sapiens_hsa034303.48154204
5Viral carcinogenesis_Homo sapiens_hsa052032.96886447
6Cell cycle_Homo sapiens_hsa041102.34477904
7Ribosome_Homo sapiens_hsa030102.31554861
8One carbon pool by folate_Homo sapiens_hsa006702.28574272
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.28366322
10Homologous recombination_Homo sapiens_hsa034402.16279401
11Nucleotide excision repair_Homo sapiens_hsa034202.13573787
12Spliceosome_Homo sapiens_hsa030402.12439029
13Non-homologous end-joining_Homo sapiens_hsa034502.10875796
14Base excision repair_Homo sapiens_hsa034102.08413090
15Fanconi anemia pathway_Homo sapiens_hsa034602.02749873
16RNA transport_Homo sapiens_hsa030132.02609821
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69499138
18Transcriptional misregulation in cancer_Homo sapiens_hsa052021.66099017
19p53 signaling pathway_Homo sapiens_hsa041151.28205043
20Pyrimidine metabolism_Homo sapiens_hsa002401.26109396
21mRNA surveillance pathway_Homo sapiens_hsa030151.23958769
22RNA polymerase_Homo sapiens_hsa030201.10460515
23RNA degradation_Homo sapiens_hsa030181.03269494
24MicroRNAs in cancer_Homo sapiens_hsa052060.95316110
25Intestinal immune network for IgA production_Homo sapiens_hsa046720.93696885
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89311270
27Asthma_Homo sapiens_hsa053100.82332292
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79913461
29Small cell lung cancer_Homo sapiens_hsa052220.79811823
30Oocyte meiosis_Homo sapiens_hsa041140.74387761
31Allograft rejection_Homo sapiens_hsa053300.71930471
32HTLV-I infection_Homo sapiens_hsa051660.71590333
33Autoimmune thyroid disease_Homo sapiens_hsa053200.68576600
34Proteasome_Homo sapiens_hsa030500.68285425
35Selenocompound metabolism_Homo sapiens_hsa004500.67935441
36Epstein-Barr virus infection_Homo sapiens_hsa051690.67718286
37Basal transcription factors_Homo sapiens_hsa030220.65145664
38Herpes simplex infection_Homo sapiens_hsa051680.65121671
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62680605
40Antigen processing and presentation_Homo sapiens_hsa046120.62262650
41Chronic myeloid leukemia_Homo sapiens_hsa052200.61920930
42Graft-versus-host disease_Homo sapiens_hsa053320.53646828
43Non-small cell lung cancer_Homo sapiens_hsa052230.51559959
44Purine metabolism_Homo sapiens_hsa002300.50538460
45Bladder cancer_Homo sapiens_hsa052190.47902746
46Apoptosis_Homo sapiens_hsa042100.44704574
47Type I diabetes mellitus_Homo sapiens_hsa049400.44526292
48Colorectal cancer_Homo sapiens_hsa052100.44254079
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43692697
50Lysine degradation_Homo sapiens_hsa003100.39903138
51Hepatitis B_Homo sapiens_hsa051610.39731313
52Biosynthesis of amino acids_Homo sapiens_hsa012300.39209291
53Renin-angiotensin system_Homo sapiens_hsa046140.38730619
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.38578314
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37974603
56mTOR signaling pathway_Homo sapiens_hsa041500.37557046
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36747281
58Pancreatic cancer_Homo sapiens_hsa052120.34361362
59TGF-beta signaling pathway_Homo sapiens_hsa043500.32358674
60Thyroid cancer_Homo sapiens_hsa052160.32293238
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.32265062
62Primary immunodeficiency_Homo sapiens_hsa053400.31479271
63Prostate cancer_Homo sapiens_hsa052150.30300253
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.29968574
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.29871659
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27806889
67Pentose phosphate pathway_Homo sapiens_hsa000300.26995942
68Viral myocarditis_Homo sapiens_hsa054160.25507899
69Glioma_Homo sapiens_hsa052140.25448730
70B cell receptor signaling pathway_Homo sapiens_hsa046620.25325150
71Hippo signaling pathway_Homo sapiens_hsa043900.24603997
72Melanoma_Homo sapiens_hsa052180.24570965
73FoxO signaling pathway_Homo sapiens_hsa040680.24413067
74Legionellosis_Homo sapiens_hsa051340.23449616
75Measles_Homo sapiens_hsa051620.23225542
76Proteoglycans in cancer_Homo sapiens_hsa052050.22584389
77Basal cell carcinoma_Homo sapiens_hsa052170.22491978
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22014002
79Pathways in cancer_Homo sapiens_hsa052000.21450970
80Hematopoietic cell lineage_Homo sapiens_hsa046400.20958392
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20879920
82Notch signaling pathway_Homo sapiens_hsa043300.20438743
83Leishmaniasis_Homo sapiens_hsa051400.19076929
84Adherens junction_Homo sapiens_hsa045200.17236035
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.17201442
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17060281
87Acute myeloid leukemia_Homo sapiens_hsa052210.16742291
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.15656601
89HIF-1 signaling pathway_Homo sapiens_hsa040660.14823657
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14744636
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14418636
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.14170185
93Endometrial cancer_Homo sapiens_hsa052130.13971474
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.12897353
95Influenza A_Homo sapiens_hsa051640.12569535
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12388462
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.11765871
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.11607668
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11163376
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.10800642
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.10422961
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10252969
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.10096298
104Focal adhesion_Homo sapiens_hsa045100.09807888
105Fructose and mannose metabolism_Homo sapiens_hsa000510.09277031
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.09152668
107Sulfur relay system_Homo sapiens_hsa041220.08712432
108Tight junction_Homo sapiens_hsa045300.07705705
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.07633651
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.06778402
111Platelet activation_Homo sapiens_hsa046110.06603106
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.06336215
113Pyruvate metabolism_Homo sapiens_hsa006200.05893673
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.04672003
115Inositol phosphate metabolism_Homo sapiens_hsa005620.04565946
116N-Glycan biosynthesis_Homo sapiens_hsa005100.03922429
117Carbon metabolism_Homo sapiens_hsa012000.03639235
118Shigellosis_Homo sapiens_hsa051310.01691327
119Toxoplasmosis_Homo sapiens_hsa051450.01411558
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.01261661
121Vitamin B6 metabolism_Homo sapiens_hsa007500.00990121
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.00858791
123Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280-0.0116224
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072-0.0088655

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »