HIST1H1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome assembly (GO:0006335)7.64529516
2DNA replication-dependent nucleosome organization (GO:0034723)7.64529516
3antibacterial humoral response (GO:0019731)7.42893458
4antimicrobial humoral response (GO:0019730)6.96512358
5innate immune response in mucosa (GO:0002227)6.87597658
6regulation of histone H3-K9 methylation (GO:0051570)6.54367859
7* chromatin assembly (GO:0031497)6.30627535
8* nucleosome assembly (GO:0006334)6.07691366
9mucosal immune response (GO:0002385)5.80405011
10organ or tissue specific immune response (GO:0002251)5.48591504
11DNA replication initiation (GO:0006270)5.15660014
12DNA strand elongation involved in DNA replication (GO:0006271)5.09646183
13* nucleosome organization (GO:0034728)5.07502249
14DNA strand elongation (GO:0022616)4.93077867
15protoporphyrinogen IX metabolic process (GO:0046501)4.83516282
16* protein-DNA complex assembly (GO:0065004)4.80998914
17mitotic sister chromatid segregation (GO:0000070)4.67932745
18telomere maintenance via semi-conservative replication (GO:0032201)4.48477126
19protein localization to chromosome, centromeric region (GO:0071459)4.28184744
20mitotic nuclear envelope disassembly (GO:0007077)4.27695220
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.24872784
22* protein-DNA complex subunit organization (GO:0071824)4.17395295
23DNA duplex unwinding (GO:0032508)4.12560609
24telomere maintenance via recombination (GO:0000722)4.02735993
25protoporphyrinogen IX biosynthetic process (GO:0006782)4.02596651
26DNA geometric change (GO:0032392)3.98057032
27mitotic recombination (GO:0006312)3.95495049
28membrane disassembly (GO:0030397)3.94460741
29nuclear envelope disassembly (GO:0051081)3.94460741
30DNA replication checkpoint (GO:0000076)3.91572550
31regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.83927199
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.80992356
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.77567911
34regulation of sister chromatid cohesion (GO:0007063)3.75615045
35nuclear pore complex assembly (GO:0051292)3.73070312
36DNA synthesis involved in DNA repair (GO:0000731)3.71455092
37meiotic chromosome segregation (GO:0045132)3.70819639
38erythrocyte maturation (GO:0043249)3.70632855
39* chromatin assembly or disassembly (GO:0006333)3.60608158
40histone lysine demethylation (GO:0070076)3.60143641
41regulation of gene silencing (GO:0060968)3.58558665
42folic acid-containing compound biosynthetic process (GO:0009396)3.54609341
43CENP-A containing nucleosome assembly (GO:0034080)3.52207648
44mitotic sister chromatid cohesion (GO:0007064)3.52112393
45DNA conformation change (GO:0071103)3.50960384
46formation of translation preinitiation complex (GO:0001731)3.49576607
47Golgi transport vesicle coating (GO:0048200)3.49500807
48COPI coating of Golgi vesicle (GO:0048205)3.49500807
49cellular hyperosmotic response (GO:0071474)3.43625286
50histone demethylation (GO:0016577)3.42300228
51mitotic chromosome condensation (GO:0007076)3.41773537
52mitochondrial DNA metabolic process (GO:0032042)3.40051618
53protein localization to kinetochore (GO:0034501)3.39743045
54regulation of centrosome cycle (GO:0046605)3.38972319
55nuclear pore organization (GO:0006999)3.36092454
56non-recombinational repair (GO:0000726)3.33754426
57double-strand break repair via nonhomologous end joining (GO:0006303)3.33754426
58chromatin remodeling at centromere (GO:0031055)3.33137065
59regulation of chromosome segregation (GO:0051983)3.33088092
60negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.28149867
61kinetochore organization (GO:0051383)3.25387661
62chromosome condensation (GO:0030261)3.25228728
63proline biosynthetic process (GO:0006561)3.25087095
64nucleobase biosynthetic process (GO:0046112)3.24944209
65porphyrin-containing compound biosynthetic process (GO:0006779)3.24605965
66ribosomal small subunit biogenesis (GO:0042274)3.17919652
67nucleotide-excision repair, DNA gap filling (GO:0006297)3.17649131
68positive regulation of chromosome segregation (GO:0051984)3.16952483
69regulation of centriole replication (GO:0046599)3.13480796
70protein demethylation (GO:0006482)3.12170496
71protein dealkylation (GO:0008214)3.12170496
72DNA unwinding involved in DNA replication (GO:0006268)3.11571233
73positive regulation of p38MAPK cascade (GO:1900745)3.10746645
74regulation of RNA export from nucleus (GO:0046831)3.05565460
75negative regulation of chromosome segregation (GO:0051985)3.03740789
76myelin maintenance (GO:0043217)3.03198821
77DNA packaging (GO:0006323)3.03006945
78viral mRNA export from host cell nucleus (GO:0046784)3.02311554
79regulation of centrosome duplication (GO:0010824)3.02187337
80chromosome segregation (GO:0007059)3.01626061
81pore complex assembly (GO:0046931)3.00475853
82telomere maintenance (GO:0000723)2.97284640
83nuclear envelope organization (GO:0006998)2.95832520
84telomere organization (GO:0032200)2.95617029
85telomere maintenance via telomere lengthening (GO:0010833)2.94093568
86mitotic metaphase plate congression (GO:0007080)2.92239254
87nucleobase-containing small molecule interconversion (GO:0015949)2.91849506
88mitotic spindle assembly checkpoint (GO:0007094)2.90209649
89activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.88236998
90positive regulation of histone methylation (GO:0031062)2.87538861
91regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.87090360
92regulation of mitotic metaphase/anaphase transition (GO:0030071)2.87090360
93spindle assembly checkpoint (GO:0071173)2.86491909
94regulation of sister chromatid segregation (GO:0033045)2.86269829
95regulation of mitotic sister chromatid separation (GO:0010965)2.86269829
96regulation of mitotic sister chromatid segregation (GO:0033047)2.86269829
97positive regulation of nuclease activity (GO:0032075)2.85824496
98regulation of translational fidelity (GO:0006450)2.85498321
99negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84948479
100negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.84948479
101negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84948479
102negative regulation of mitotic sister chromatid separation (GO:2000816)2.84948479
103negative regulation of sister chromatid segregation (GO:0033046)2.84948479
104somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83724001
105somatic hypermutation of immunoglobulin genes (GO:0016446)2.83724001
106negative regulation of DNA repair (GO:0045738)2.83198515
107maturation of SSU-rRNA (GO:0030490)2.82725650
108DNA replication-independent nucleosome organization (GO:0034724)2.79934874
109DNA replication-independent nucleosome assembly (GO:0006336)2.79934874
110histone phosphorylation (GO:0016572)2.78054072
111endoplasmic reticulum unfolded protein response (GO:0030968)2.77720133
112spindle checkpoint (GO:0031577)2.76679670
113dosage compensation (GO:0007549)2.76666949
114positive regulation of cell cycle checkpoint (GO:1901978)2.76284768
115mitotic spindle checkpoint (GO:0071174)2.75503599
116definitive hemopoiesis (GO:0060216)2.74393387
117response to methylmercury (GO:0051597)2.73857064
118metaphase plate congression (GO:0051310)2.71634387
119hepatocyte apoptotic process (GO:0097284)2.71234067
120tetrapyrrole biosynthetic process (GO:0033014)2.70214544
121negative regulation of histone methylation (GO:0031061)2.69125256
122iron ion import (GO:0097286)2.68156453
123cellular response to unfolded protein (GO:0034620)2.67431868
124pteridine-containing compound biosynthetic process (GO:0042559)2.65327397
125hemoglobin metabolic process (GO:0020027)2.64563222
126regulation of nuclease activity (GO:0032069)2.64180490
127sequestering of metal ion (GO:0051238)2.63846094
128regulation of posttranscriptional gene silencing (GO:0060147)2.62663216
129regulation of gene silencing by miRNA (GO:0060964)2.62663216
130regulation of gene silencing by RNA (GO:0060966)2.62663216
131heme biosynthetic process (GO:0006783)2.61658370
132histone H3-K36 demethylation (GO:0070544)2.59827637
133porphyrin-containing compound metabolic process (GO:0006778)2.58595275
134ER-nucleus signaling pathway (GO:0006984)2.57155547
135cellular response to osmotic stress (GO:0071470)2.56480033
136maternal placenta development (GO:0001893)2.54023707
137regulation of nucleobase-containing compound transport (GO:0032239)2.53204387
138L-alpha-amino acid transmembrane transport (GO:1902475)2.48535527
139positive regulation of histone deacetylation (GO:0031065)2.47919278
140cellular response to topologically incorrect protein (GO:0035967)2.46908700
141response to UV-C (GO:0010225)2.46854086
142growth hormone receptor signaling pathway (GO:0060396)2.46208885
143endocrine pancreas development (GO:0031018)2.43137451
144response to arsenic-containing substance (GO:0046685)2.41247054
145spindle assembly involved in mitosis (GO:0090307)2.39295375
146pentose-phosphate shunt (GO:0006098)2.39170357
147positive regulation of B cell differentiation (GO:0045579)2.35728684
148defense response to Gram-positive bacterium (GO:0050830)2.35613728
149creatine metabolic process (GO:0006600)2.33689681
150protein autoprocessing (GO:0016540)2.32906149
151DNA topological change (GO:0006265)2.28778969
1524-hydroxyproline metabolic process (GO:0019471)2.25417890
153negative regulation of B cell proliferation (GO:0030889)2.25252199
154protein localization to endosome (GO:0036010)2.24088310
155lipopolysaccharide biosynthetic process (GO:0009103)2.20061851
156regulation of histone methylation (GO:0031060)2.19418751
157response to lead ion (GO:0010288)2.18721812
158positive regulation of fatty acid beta-oxidation (GO:0032000)2.18607522
159NADPH regeneration (GO:0006740)2.18087484
160translesion synthesis (GO:0019985)2.17808085
161neutrophil activation involved in immune response (GO:0002283)2.17130712
162sister chromatid segregation (GO:0000819)2.16407709
163heme metabolic process (GO:0042168)2.16325046
164histone H3-K9 demethylation (GO:0033169)2.15497752
165negative regulation of fatty acid biosynthetic process (GO:0045717)2.15429736
166exocrine pancreas development (GO:0031017)2.15071401
167IMP metabolic process (GO:0046040)2.15018195
168cortical actin cytoskeleton organization (GO:0030866)2.13959844
169response to lipoprotein particle (GO:0055094)2.13468903
170positive regulation of SMAD protein import into nucleus (GO:0060391)2.11633876
171response to endoplasmic reticulum stress (GO:0034976)2.11478958
172maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.11203041
173low-density lipoprotein particle clearance (GO:0034383)2.10874292

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.23314765
2E2F7_22180533_ChIP-Seq_HELA_Human3.62828932
3EGR1_23403033_ChIP-Seq_LIVER_Mouse2.90849493
4TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.69285044
5* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.58464850
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.57738584
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.37879529
8* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29709355
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28356391
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse17.9972752
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.95992019
12* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.90958735
13SOX2_16153702_ChIP-ChIP_HESCs_Human1.77290018
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.77064904
15CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73065791
16GATA1_22025678_ChIP-Seq_K562_Human1.72839344
17CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.71961204
18RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63884914
19* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59214792
20MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56032921
21MYC_19079543_ChIP-ChIP_MESCs_Mouse1.49675862
22* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.43406121
23THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41531771
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41371994
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39929913
26* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.37019246
27ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36609229
28XRN2_22483619_ChIP-Seq_HELA_Human1.36586611
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34743674
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32801860
31GATA1_19941826_ChIP-Seq_K562_Human1.32345530
32* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.31206582
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.28837119
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27473242
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.26717221
36* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24010556
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21144534
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20160664
39IRF1_19129219_ChIP-ChIP_H3396_Human1.19902529
40DCP1A_22483619_ChIP-Seq_HELA_Human1.19868476
41HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18621263
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17677309
43* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.17403862
44* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17275277
45VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17227369
46* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16434623
47* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16236573
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.14804784
49* CLOCK_20551151_ChIP-Seq_293T_Human1.13163078
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12219967
51* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11913512
52EST1_17652178_ChIP-ChIP_JURKAT_Human1.08075211
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07848426
54FOXP3_21729870_ChIP-Seq_TREG_Human1.07784022
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07237898
56* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06497526
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05233770
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04382114
59ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03556615
60* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02903314
61* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02835789
62CIITA_25753668_ChIP-Seq_RAJI_Human1.02717023
63* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00789551
64IRF8_22096565_ChIP-ChIP_GC-B_Human0.98409820
65NANOG_16153702_ChIP-ChIP_HESCs_Human0.98200810
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97908742
67TTF2_22483619_ChIP-Seq_HELA_Human0.96714210
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96467731
69SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95931477
70STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95826013
71NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95064150
72KDM5A_27292631_Chip-Seq_BREAST_Human0.94932154
73* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.93727830
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93356754
75* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92793658
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92592321
77ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91094329
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90980234
79* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.90224857
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90125122
81* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89625646
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88180084
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87881500
84GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87768253
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87724993
86GABP_17652178_ChIP-ChIP_JURKAT_Human0.85335736
87TCF3_18692474_ChIP-Seq_MESCs_Mouse0.85292170
88* VDR_21846776_ChIP-Seq_THP-1_Human0.85074570
89KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84836309
90PKCTHETA_26484144_Chip-Seq_BREAST_Human0.83104757
91* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82844468
92ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82758280
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82095223
94MYC_22102868_ChIP-Seq_BL_Human0.82056171
95* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81932542
96MYC_18940864_ChIP-ChIP_HL60_Human0.80944478
97GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80849911
98FOXO3_23340844_ChIP-Seq_DLD1_Human0.79975371
99* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.79760980
100ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.79272287
101MYB_26560356_Chip-Seq_TH1_Human0.78834876
102* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78803278
103* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.78370670
104MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.78054129
105MAF_26560356_Chip-Seq_TH1_Human0.76796458
106FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.76710732
107SCL_19346495_ChIP-Seq_HPC-7_Human0.76358440
108AR_21909140_ChIP-Seq_LNCAP_Human0.76018073
109TRIM28_21343339_ChIP-Seq_HEK293_Human0.75138939
110* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.75075483
111STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.74935935
112CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72533838
113* GATA6_25053715_ChIP-Seq_YYC3_Human0.72437957
114ELK1_19687146_ChIP-ChIP_HELA_Human0.71933804
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71800187
116* TCF7_22412390_ChIP-Seq_EML_Mouse0.70969534
117PPARA_22158963_ChIP-Seq_LIVER_Mouse0.70507645
118ZNF263_19887448_ChIP-Seq_K562_Human0.69045588
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.68441039
120RXR_22158963_ChIP-Seq_LIVER_Mouse0.68190400
121GATA2_19941826_ChIP-Seq_K562_Human0.67940790
122TFEB_21752829_ChIP-Seq_HELA_Human0.67247369
123FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.67097306
124SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.65211992
125* RUNX1_22412390_ChIP-Seq_EML_Mouse0.64705943
126KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.64553185
127SOX2_27498859_Chip-Seq_STOMACH_Mouse0.64363809
128SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.63727364
129SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.63727364
130* VDR_23849224_ChIP-Seq_CD4+_Human0.63451047
131MYC_19030024_ChIP-ChIP_MESCs_Mouse0.63229088
132FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.63126708
133NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.62883217
134FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.62591595
135* CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.61176670
136* LXR_22158963_ChIP-Seq_LIVER_Mouse0.60837157
137* UTX_26944678_Chip-Seq_JUKART_Human0.60701912
138WT1_19549856_ChIP-ChIP_CCG9911_Human0.58941093
139NCOR1_26117541_ChIP-Seq_K562_Human0.58673490
140KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.58229258
141* VDR_24763502_ChIP-Seq_THP-1_Human0.58098370
142* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.57618672
143PADI4_21655091_ChIP-ChIP_MCF-7_Human0.57274823
144HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.56327130

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.86204437
2MP0004957_abnormal_blastocyst_morpholog3.48970871
3MP0003693_abnormal_embryo_hatching3.41660729
4MP0009697_abnormal_copulation3.35183507
5MP0003656_abnormal_erythrocyte_physiolo3.32389455
6MP0002877_abnormal_melanocyte_morpholog3.30123705
7MP0003705_abnormal_hypodermis_morpholog2.95755951
8MP0006054_spinal_hemorrhage2.94592761
9MP0010307_abnormal_tumor_latency2.84455879
10MP0008438_abnormal_cutaneous_collagen2.79843794
11MP0010234_abnormal_vibrissa_follicle2.74829773
12MP0008058_abnormal_DNA_repair2.70970761
13MP0004147_increased_porphyrin_level2.55435669
14MP0010352_gastrointestinal_tract_polyps2.27987671
15MP0008007_abnormal_cellular_replicative2.25660458
16MP0002396_abnormal_hematopoietic_system2.19665585
17MP0003300_gastrointestinal_ulcer2.19348310
18MP0008932_abnormal_embryonic_tissue2.15879822
19MP0005083_abnormal_biliary_tract2.11414892
20MP0002132_abnormal_respiratory_system2.07265345
21MP0003786_premature_aging1.97281756
22MP0005076_abnormal_cell_differentiation1.79750827
23MP0003763_abnormal_thymus_physiology1.77072676
24MP0004185_abnormal_adipocyte_glucose1.75278354
25MP0003806_abnormal_nucleotide_metabolis1.72119251
26MP0005645_abnormal_hypothalamus_physiol1.59059073
27MP0002166_altered_tumor_susceptibility1.58131087
28MP0005058_abnormal_lysosome_morphology1.53829500
29MP0005275_abnormal_skin_tensile1.51605128
30MP0005451_abnormal_body_composition1.49126846
31MP0001873_stomach_inflammation1.48252540
32MP0002009_preneoplasia1.48249975
33MP0005257_abnormal_intraocular_pressure1.46651990
34MP0003566_abnormal_cell_adhesion1.46529740
35MP0008995_early_reproductive_senescence1.46471154
36MP0000003_abnormal_adipose_tissue1.44373444
37MP0000013_abnormal_adipose_tissue1.42660051
38MP0005220_abnormal_exocrine_pancreas1.42321612
39MP0001672_abnormal_embryogenesis/_devel1.40133724
40MP0005380_embryogenesis_phenotype1.40133724
41* MP0000313_abnormal_cell_death1.37390816
42MP0000733_abnormal_muscle_development1.35874650
43MP0003984_embryonic_growth_retardation1.35050282
44MP0010094_abnormal_chromosome_stability1.33333177
45MP0003718_maternal_effect1.31568366
46MP0002088_abnormal_embryonic_growth/wei1.29061825
47MP0010678_abnormal_skin_adnexa1.27686373
48MP0001727_abnormal_embryo_implantation1.27677951
49MP0002139_abnormal_hepatobiliary_system1.26556442
50* MP0002080_prenatal_lethality1.26241560
51MP0003453_abnormal_keratinocyte_physiol1.25659030
52MP0003191_abnormal_cellular_cholesterol1.25445914
53MP0000537_abnormal_urethra_morphology1.22621916
54MP0001958_emphysema1.21230153
55* MP0001697_abnormal_embryo_size1.20422561
56MP0006035_abnormal_mitochondrial_morpho1.20345573
57MP0003283_abnormal_digestive_organ1.13794232
58MP0004947_skin_inflammation1.13691591
59MP0005408_hypopigmentation1.13445205
60MP0000358_abnormal_cell_content/1.13445181
61MP0005397_hematopoietic_system_phenotyp1.13135319
62MP0001545_abnormal_hematopoietic_system1.13135319
63MP0002138_abnormal_hepatobiliary_system1.12380515
64MP0002060_abnormal_skin_morphology1.10762213
65MP0001944_abnormal_pancreas_morphology1.09674795
66MP0005375_adipose_tissue_phenotype1.09148675
67MP0009840_abnormal_foam_cell1.07697793
68MP0003436_decreased_susceptibility_to1.06557450
69MP0005647_abnormal_sex_gland1.05372351
70MP0004197_abnormal_fetal_growth/weight/1.04830397
71MP0004233_abnormal_muscle_weight1.03768684
72MP0006072_abnormal_retinal_apoptosis1.03766426
73MP0009643_abnormal_urine_homeostasis1.02584466
74MP0004808_abnormal_hematopoietic_stem1.01764301
75MP0001666_abnormal_nutrient_absorption1.01296648
76MP0005023_abnormal_wound_healing1.00837455
77MP0000490_abnormal_crypts_of1.00363253
78MP0004264_abnormal_extraembryonic_tissu0.98722036
79* MP0000703_abnormal_thymus_morphology0.98254549
80MP0001849_ear_inflammation0.98019343
81MP0004272_abnormal_basement_membrane0.97896100
82MP0002896_abnormal_bone_mineralization0.95993102
83MP0005666_abnormal_adipose_tissue0.95831240
84MP0000462_abnormal_digestive_system0.94385753
85MP0004130_abnormal_muscle_cell0.93945834
86MP0002933_joint_inflammation0.92881485
87MP0000685_abnormal_immune_system0.92426274
88MP0002006_tumorigenesis0.92326484
89MP0000372_irregular_coat_pigmentation0.91469603
90MP0002693_abnormal_pancreas_physiology0.91299883
91MP0005360_urolithiasis0.88820151
92MP0002697_abnormal_eye_size0.88452079
93MP0001915_intracranial_hemorrhage0.87772706
94MP0000858_altered_metastatic_potential0.87281470
95MP0003077_abnormal_cell_cycle0.86138278
96MP0000609_abnormal_liver_physiology0.85912541
97MP0002092_abnormal_eye_morphology0.85597367
98MP0003221_abnormal_cardiomyocyte_apopto0.84587348
99MP0001661_extended_life_span0.84107567
100* MP0002084_abnormal_developmental_patter0.82741179
101MP0003279_aneurysm0.82731280
102MP0002429_abnormal_blood_cell0.82002430
103MP0000350_abnormal_cell_proliferation0.81106125
104MP0003950_abnormal_plasma_membrane0.80362485
105MP0000747_muscle_weakness0.80214212
106MP0000383_abnormal_hair_follicle0.79776062
107* MP0002085_abnormal_embryonic_tissue0.79427764
108MP0005503_abnormal_tendon_morphology0.79286136
109MP0004043_abnormal_pH_regulation0.79031501
110MP0001243_abnormal_dermal_layer0.78649671
111MP0002928_abnormal_bile_duct0.78197960
112MP0001929_abnormal_gametogenesis0.77624018
113MP0005384_cellular_phenotype0.76962983
114MP0002210_abnormal_sex_determination0.75696529
115MP0005501_abnormal_skin_physiology0.75204025
116MP0001730_embryonic_growth_arrest0.74082064
117MP0005621_abnormal_cell_physiology0.73909971
118MP0002019_abnormal_tumor_incidence0.73182996
119MP0003795_abnormal_bone_structure0.71969199
120MP0005636_abnormal_mineral_homeostasis0.71356072
121MP0003303_peritoneal_inflammation0.71125625
122MP0000371_diluted_coat_color0.71034187
123MP0003195_calcinosis0.70691986
124MP0009931_abnormal_skin_appearance0.70551643
125MP0001800_abnormal_humoral_immune0.69997200
126MP0001835_abnormal_antigen_presentation0.69994065
127MP0003252_abnormal_bile_duct0.69855526
128MP0002078_abnormal_glucose_homeostasis0.69825064
129MP0003111_abnormal_nucleus_morphology0.69713991
130MP0000598_abnormal_liver_morphology0.69411489
131MP0000689_abnormal_spleen_morphology0.69249878
132* MP0002086_abnormal_extraembryonic_tissu0.69023611
133MP0003091_abnormal_cell_migration0.68436468
134MP0003941_abnormal_skin_development0.66879116
135MP0000465_gastrointestinal_hemorrhage0.66788189
136MP0002398_abnormal_bone_marrow0.66383851
137MP0003699_abnormal_female_reproductive0.66128679
138MP0001533_abnormal_skeleton_physiology0.65569140
139MP0005187_abnormal_penis_morphology0.64775682
140* MP0002722_abnormal_immune_system0.64765538
141MP0000015_abnormal_ear_pigmentation0.64754643
142MP0001191_abnormal_skin_condition0.64717718
143MP0005623_abnormal_meninges_morphology0.63852399
144MP0003315_abnormal_perineum_morphology0.63830464
145MP0003186_abnormal_redox_activity0.62657272
146MP0002136_abnormal_kidney_physiology0.62598180
147MP0009703_decreased_birth_body0.61953032
148MP0000377_abnormal_hair_follicle0.60941258
149MP0001145_abnormal_male_reproductive0.60808411
150MP0005464_abnormal_platelet_physiology0.60076065
151MP0000716_abnormal_immune_system0.59439209
152MP0002160_abnormal_reproductive_system0.58573263
153MP0009278_abnormal_bone_marrow0.57159497
154MP0008770_decreased_survivor_rate0.56206225
155MP0003937_abnormal_limbs/digits/tail_de0.56180608
156MP0009333_abnormal_splenocyte_physiolog0.53770198
157MP0004036_abnormal_muscle_relaxation0.53501822
158MP0002970_abnormal_white_adipose0.51878952
159MP0010155_abnormal_intestine_physiology0.51538778

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.74568095
2Chromsome breakage (HP:0040012)5.31515430
3Poikilocytosis (HP:0004447)4.82722404
4IgM deficiency (HP:0002850)4.78640133
5Acanthocytosis (HP:0001927)4.48737980
6IgA deficiency (HP:0002720)4.12918378
7Colitis (HP:0002583)4.02405370
8Abnormality of pyrimidine metabolism (HP:0004353)3.95007949
9Hypoglycemic coma (HP:0001325)3.75715175
10Hypoglycemic seizures (HP:0002173)3.42208469
11Hyperinsulinemic hypoglycemia (HP:0000825)3.40121480
12Abnormality of the heme biosynthetic pathway (HP:0010472)3.35686403
13Birth length less than 3rd percentile (HP:0003561)3.34190969
14Abnormality of chromosome stability (HP:0003220)3.28553582
15Abnormality of the pancreatic islet cells (HP:0006476)3.22837294
16Abnormality of endocrine pancreas physiology (HP:0012093)3.22837294
17Ulnar bowing (HP:0003031)3.17256700
18Pancreatic islet-cell hyperplasia (HP:0004510)3.15369692
19Reticulocytopenia (HP:0001896)3.10986556
20Abnormality of the preputium (HP:0100587)3.07953547
21Cholecystitis (HP:0001082)3.05410996
22Abnormal gallbladder physiology (HP:0012438)3.05410996
23Hypochromic microcytic anemia (HP:0004840)3.02013602
24Abnormal gallbladder morphology (HP:0012437)2.89043418
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.88695359
26Ankyloglossia (HP:0010296)2.85612074
27Reticulocytosis (HP:0001923)2.85518495
28Cholelithiasis (HP:0001081)2.74200874
29Myelodysplasia (HP:0002863)2.69827846
30Hematochezia (HP:0002573)2.67193598
31Cerebral aneurysm (HP:0004944)2.63794108
32Premature rupture of membranes (HP:0001788)2.63189797
33Cutaneous melanoma (HP:0012056)2.63025056
34Abnormality of the fingertips (HP:0001211)2.60656207
3511 pairs of ribs (HP:0000878)2.56718625
36Squamous cell carcinoma (HP:0002860)2.52886424
37Symptomatic seizures (HP:0011145)2.51606025
38Sandal gap (HP:0001852)2.47927404
39Abnormality of cells of the erythroid lineage (HP:0012130)2.36994993
40Pallor (HP:0000980)2.36050993
41Erythema (HP:0010783)2.35617641
42Hyperglycemia (HP:0003074)2.35109951
43Abnormality of T cell physiology (HP:0011840)2.34412359
44Abnormality of the carotid arteries (HP:0005344)2.34097101
45Dysmetric saccades (HP:0000641)2.32745227
46Round ear (HP:0100830)2.32102126
47Increased CSF protein (HP:0002922)2.31687869
48Ketoacidosis (HP:0001993)2.31677782
49Abnormality of the ileum (HP:0001549)2.31439634
50Cafe-au-lait spot (HP:0000957)2.31012022
51Duodenal stenosis (HP:0100867)2.30979571
52Small intestinal stenosis (HP:0012848)2.30979571
53Metaphyseal cupping (HP:0003021)2.30280482
54Nasal polyposis (HP:0100582)2.29267638
55Acute myeloid leukemia (HP:0004808)2.28678540
56Microvesicular hepatic steatosis (HP:0001414)2.28525722
57Hyperbilirubinemia (HP:0002904)2.25297848
58Orthostatic hypotension (HP:0001278)2.25049657
59Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24922615
60Hemorrhage of the eye (HP:0011885)2.24734673
61Meckel diverticulum (HP:0002245)2.23563154
62Bowed forearm bones (HP:0003956)2.23491288
63Bowing of the arm (HP:0006488)2.23491288
64Abnormality of DNA repair (HP:0003254)2.23057413
65Autoimmune hemolytic anemia (HP:0001890)2.22223798
66Gastrointestinal stroma tumor (HP:0100723)2.22098749
67Insomnia (HP:0100785)2.22083715
68Deep philtrum (HP:0002002)2.22067280
69Osteomalacia (HP:0002749)2.18914921
70Abnormality of reticulocytes (HP:0004312)2.17825461
71Inflammation of the large intestine (HP:0002037)2.16542473
72Nephroblastoma (Wilms tumor) (HP:0002667)2.16414796
73Progressive external ophthalmoplegia (HP:0000590)2.16022150
74Abnormality of oral frenula (HP:0000190)2.15603325
75Clubbing of toes (HP:0100760)2.15119560
76Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.15058174
77Septate vagina (HP:0001153)2.12307654
78Xanthomatosis (HP:0000991)2.12242353
79Entropion (HP:0000621)2.11654493
80Abnormality of cochlea (HP:0000375)2.11206975
81Hypoalphalipoproteinemia (HP:0003233)2.09791385
82Persistence of primary teeth (HP:0006335)2.08450048
83Gastrointestinal inflammation (HP:0004386)2.08382447
84Macrocytic anemia (HP:0001972)2.07626205
85Exercise-induced muscle cramps (HP:0003710)2.07348918
86Medulloblastoma (HP:0002885)2.06969258
87Duplicated collecting system (HP:0000081)2.02304505
88Truncus arteriosus (HP:0001660)2.00379883
89Abnormality of the calcaneus (HP:0008364)1.98794295
90Abnormality of the gallbladder (HP:0005264)1.98368200
91Macroorchidism (HP:0000053)1.98227506
92Embryonal renal neoplasm (HP:0011794)1.96119982
93Mitral stenosis (HP:0001718)1.96072116
94Vertebral clefting (HP:0008428)1.95283878
95Basal cell carcinoma (HP:0002671)1.95127045
96Thrombocytosis (HP:0001894)1.94813628
97Missing ribs (HP:0000921)1.94506821
98Intrahepatic cholestasis (HP:0001406)1.94388996
99Hyporeflexia of lower limbs (HP:0002600)1.94257403
100Abnormal foot bone ossification (HP:0010675)1.93622039
101Paralysis (HP:0003470)1.92623843
102Radial bowing (HP:0002986)1.91210087
103Acute lymphatic leukemia (HP:0006721)1.90811571
104Abnormality of aromatic amino acid family metabolism (HP:0004338)1.90270338
105Papilloma (HP:0012740)1.89052351
106Verrucae (HP:0200043)1.89052351
107Abnormal vertebral ossification (HP:0100569)1.87681862
108Abdominal distention (HP:0003270)1.86563517
109Mitral valve prolapse (HP:0001634)1.86504168
110Lymphoma (HP:0002665)1.86337474
111Chronic diarrhea (HP:0002028)1.86188953
112Tibial bowing (HP:0002982)1.85123077
113Hypoplasia of the thymus (HP:0000778)1.84747077
114Increased connective tissue (HP:0009025)1.84362520
115Thoracolumbar scoliosis (HP:0002944)1.84245967
116Difficulty running (HP:0009046)1.84137733
117Hepatocellular carcinoma (HP:0001402)1.83660138
118Abnormal number of erythroid precursors (HP:0012131)1.83605009
119Ureteral duplication (HP:0000073)1.83234358
120Hypergonadotropic hypogonadism (HP:0000815)1.82040031
121Hypopigmentation of the fundus (HP:0007894)1.81588082
122Lower limb hyperreflexia (HP:0002395)1.81329601
123Thyroiditis (HP:0100646)1.81314109
124Aortic aneurysm (HP:0004942)1.80749560
125Ankle contracture (HP:0006466)1.80716641
126Increased nuchal translucency (HP:0010880)1.80363352
127Spastic diplegia (HP:0001264)1.80101588
128Insulin-resistant diabetes mellitus (HP:0000831)1.79883243
129Relative macrocephaly (HP:0004482)1.79412726
130Abnormality of the peritoneum (HP:0002585)1.79149369
131Buphthalmos (HP:0000557)1.78799224
132Osteolytic defects of the phalanges of the hand (HP:0009771)1.78636458
133Osteolytic defects of the hand bones (HP:0009699)1.78636458
134Myocardial infarction (HP:0001658)1.78096492
135Cellulitis (HP:0100658)1.77676668
136Abnormality of the renal collecting system (HP:0004742)1.76952236
137Cortical dysplasia (HP:0002539)1.76622839
138Arteriovenous malformation (HP:0100026)1.76369815
139Papillary thyroid carcinoma (HP:0002895)1.76082050
140Diaphragmatic weakness (HP:0009113)1.75857887
141Insulin resistance (HP:0000855)1.75039232
142Distal arthrogryposis (HP:0005684)1.74837684
143Aplasia/Hypoplasia of the earlobes (HP:0009906)1.74651404
144Poikiloderma (HP:0001029)1.74599682
145Abnormality of the duodenum (HP:0002246)1.74177719
146Prominent nose (HP:0000448)1.74170316
147Protuberant abdomen (HP:0001538)1.74082032
148T lymphocytopenia (HP:0005403)1.73334124
149Leukopenia (HP:0001882)1.72895877
150Limb hypertonia (HP:0002509)1.72835405
151Biliary tract neoplasm (HP:0100574)1.72377797
152Onycholysis (HP:0001806)1.71895938
153Ulnar deviation of the wrist (HP:0003049)1.71667174
154Leiomyosarcoma (HP:0100243)1.70424192
155Uterine leiomyosarcoma (HP:0002891)1.70424192
156Polycythemia (HP:0001901)1.70313796
157Sloping forehead (HP:0000340)1.69675436
158Protrusio acetabuli (HP:0003179)1.69176755
159Spinal muscular atrophy (HP:0007269)1.68890836
160Mucosal telangiectasiae (HP:0100579)1.68820945
161Rhabdomyosarcoma (HP:0002859)1.68676401
162Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.68017773
163Long clavicles (HP:0000890)1.67255418
164Abnormality of nail color (HP:0100643)1.67233055
165Overlapping toe (HP:0001845)1.67022767
166Peritonitis (HP:0002586)1.66065483
167Severe short stature (HP:0003510)1.65848549
168Scapular winging (HP:0003691)1.65552433
169Pathologic fracture (HP:0002756)1.65443161
170Myoglobinuria (HP:0002913)1.65406905
171Small epiphyses (HP:0010585)1.64418253
172Hypoplastic ischia (HP:0003175)1.64292576
173Type 1 muscle fiber predominance (HP:0003803)1.63643251
174Subacute progressive viral hepatitis (HP:0006572)1.63273596
175Ketosis (HP:0001946)1.62540505
176Dysostosis multiplex (HP:0000943)1.61530970
177Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.61481092
178Wormian bones (HP:0002645)1.60702960
179Congenital glaucoma (HP:0001087)1.58790900
180Nonimmune hydrops fetalis (HP:0001790)1.58191326
181Back pain (HP:0003418)1.58151065
182Late onset (HP:0003584)1.55441939
183Abnormality of iron homeostasis (HP:0011031)1.54827469
184Interstitial pulmonary disease (HP:0006530)1.54044566
185Peripheral demyelination (HP:0011096)1.53970407
186Abnormality of the vasculature of the conjunctiva (HP:0008054)1.53687425

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK18.59376634
2ZAK5.68124894
3RPS6KA53.10544605
4VRK13.02935977
5MAP3K102.97340152
6STK42.88127506
7PKN22.26352688
8CDK92.18277397
9TTK1.93841403
10TTN1.92962037
11BUB11.88891518
12TRIB31.86813096
13SCYL21.83353211
14EPHA21.58059086
15FLT31.56274754
16MAPK151.53364422
17PIM11.52223641
18DYRK1B1.47382921
19PKN11.46622414
20NEK11.46195646
21EEF2K1.45953216
22BRSK21.45752114
23DYRK31.31012388
24MET1.30847445
25DAPK31.28080693
26CCNB11.27875780
27MAP3K81.27209390
28SRPK11.22322458
29PLK41.21164458
30FRK1.18341481
31RPS6KB21.13077361
32SMG11.12219538
33WEE11.08919521
34PASK1.08526809
35AURKB1.06086520
36CDC71.01775429
37RAF11.00591686
38BRAF0.99553877
39CDK120.98398248
40* CHEK20.95812604
41MST1R0.93176268
42EPHB10.91803660
43ERN10.90010698
44CAMK1D0.89740294
45PTK60.88827847
46ICK0.88097866
47CLK10.86107040
48INSRR0.84426278
49FGFR20.84340735
50BTK0.84320101
51HIPK20.83808771
52STK100.83476357
53PLK10.82773921
54MAP2K20.82387458
55LRRK20.81539578
56TGFBR20.79582265
57TRPM70.76269612
58BMPR20.76146801
59BCKDK0.75865990
60MELK0.74777662
61NEK20.74766018
62PIK3CA0.72887552
63MAP3K20.71614624
64JAK20.71313350
65CHEK10.71132331
66SIK10.70728522
67PRPF4B0.70357694
68IRAK30.69434075
69CDK70.65027888
70RIPK10.64513516
71PIK3CG0.62895484
72GRK60.57548411
73PBK0.57546723
74CDK60.56579166
75CDK80.56461939
76PIM20.55578139
77PRKAA10.55402535
78NME20.54499215
79TSSK60.51935467
80AKT30.50399163
81MTOR0.49423539
82EPHA30.49248164
83NEK90.49029526
84RIPK40.48975599
85AURKA0.48719261
86CDK20.47400654
87MAPKAPK30.47161349
88PLK30.46742057
89CHUK0.45123661
90PAK20.44809201
91IKBKB0.44447110
92STK30.43819221
93BRD40.43134554
94GSK3A0.43073258
95CDK40.42833818
96BRSK10.42833517
97MST40.42508723
98WNK10.40880769
99STK390.40810704
100AKT20.40695641
101LATS10.39714636
102CDK10.39648824
103EIF2AK10.39543920
104PRKCQ0.39339629
105IRAK40.38900274
106MAP2K30.38356086
107RET0.38084709
108MAP3K30.36707306
109FGFR40.35605220
110CAMK1G0.35089811
111STK160.35050984
112TBK10.34833241
113PDGFRB0.34787447
114PDGFRA0.34746377
115SYK0.34465671
116CSNK1D0.33761947
117ROCK10.33255662
118PDK20.32572098
119FGFR30.32495918
120ILK0.32463613
121EIF2AK30.31778089
122WNK40.30930140
123ITK0.30387311
124RPS6KB10.29459300
125PAK10.29335636
126PRKAA20.29315125
127BMX0.28850431
128MAP2K10.28563716
129CSF1R0.28061018
130MARK30.27932724
131WNK30.26471340
132KSR20.25867969
133MAPKAPK50.25654312
134PAK40.24915309
135BLK0.24708000
136MAPK110.23627716
137PRKD10.23143138
138ATM0.23134104
139MAP3K40.23049382
140CSNK2A20.22602684
141TGFBR10.22307420
142ATR0.22084126
143KSR10.21967399
144JAK30.21509086
145TYK20.21263010
146TEC0.20511221
147EIF2AK20.20376772
148NEK60.19355297
149TAF10.17316281
150MAPK140.15720581
151PRKDC0.14974004
152IRAK20.14231809
153CAMK40.13473083

Predicted pathways (KEGG)

RankGene SetZ-score
1Alcoholism_Homo sapiens_hsa050346.56655919
2Viral carcinogenesis_Homo sapiens_hsa052033.38178928
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.08814580
4Systemic lupus erythematosus_Homo sapiens_hsa0532211.7451483
5Transcriptional misregulation in cancer_Homo sapiens_hsa052021.98482028
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.71141303
7Nucleotide excision repair_Homo sapiens_hsa034201.69770624
8Base excision repair_Homo sapiens_hsa034101.57509690
9Homologous recombination_Homo sapiens_hsa034401.54983444
10Fanconi anemia pathway_Homo sapiens_hsa034601.54915009
11Ribosome_Homo sapiens_hsa030101.43701807
12Sulfur metabolism_Homo sapiens_hsa009201.38203784
13RNA transport_Homo sapiens_hsa030131.30842509
14Selenocompound metabolism_Homo sapiens_hsa004501.27918191
15Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22814803
16Pyrimidine metabolism_Homo sapiens_hsa002401.06148861
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03006492
18Spliceosome_Homo sapiens_hsa030401.02136677
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96638986
20Biosynthesis of amino acids_Homo sapiens_hsa012300.95667137
21Nitrogen metabolism_Homo sapiens_hsa009100.94578866
22Non-homologous end-joining_Homo sapiens_hsa034500.94418719
23Small cell lung cancer_Homo sapiens_hsa052220.86913353
24Chronic myeloid leukemia_Homo sapiens_hsa052200.86240294
25Pentose phosphate pathway_Homo sapiens_hsa000300.85075200
26One carbon pool by folate_Homo sapiens_hsa006700.84816114
27Folate biosynthesis_Homo sapiens_hsa007900.84143780
28Arginine biosynthesis_Homo sapiens_hsa002200.79792274
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77954838
30Bladder cancer_Homo sapiens_hsa052190.76445746
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71633130
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71203401
33Carbon metabolism_Homo sapiens_hsa012000.70747337
34MicroRNAs in cancer_Homo sapiens_hsa052060.70101354
35Lysine degradation_Homo sapiens_hsa003100.67006828
36Apoptosis_Homo sapiens_hsa042100.66818316
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66284714
38Insulin resistance_Homo sapiens_hsa049310.64767140
39p53 signaling pathway_Homo sapiens_hsa041150.64738158
40RNA degradation_Homo sapiens_hsa030180.64623797
41Cell cycle_Homo sapiens_hsa041100.64400034
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62600758
43Graft-versus-host disease_Homo sapiens_hsa053320.61755479
44Fatty acid degradation_Homo sapiens_hsa000710.60951100
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60413825
46ABC transporters_Homo sapiens_hsa020100.59599274
47mRNA surveillance pathway_Homo sapiens_hsa030150.59304375
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58430762
49ECM-receptor interaction_Homo sapiens_hsa045120.57991129
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57781448
51Epstein-Barr virus infection_Homo sapiens_hsa051690.56445484
52Other glycan degradation_Homo sapiens_hsa005110.55074651
53B cell receptor signaling pathway_Homo sapiens_hsa046620.54525528
54Lysosome_Homo sapiens_hsa041420.54375613
55Protein digestion and absorption_Homo sapiens_hsa049740.53655146
56RNA polymerase_Homo sapiens_hsa030200.52521087
57Focal adhesion_Homo sapiens_hsa045100.50999295
58Non-small cell lung cancer_Homo sapiens_hsa052230.50976142
59Purine metabolism_Homo sapiens_hsa002300.50819696
60Pancreatic cancer_Homo sapiens_hsa052120.49005262
61Pyruvate metabolism_Homo sapiens_hsa006200.48978161
62Fructose and mannose metabolism_Homo sapiens_hsa000510.48137785
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47860535
64Glioma_Homo sapiens_hsa052140.47797532
65Basal transcription factors_Homo sapiens_hsa030220.47673129
66Colorectal cancer_Homo sapiens_hsa052100.47580499
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.47208478
68Primary immunodeficiency_Homo sapiens_hsa053400.46263917
69Prostate cancer_Homo sapiens_hsa052150.45919139
70Protein export_Homo sapiens_hsa030600.45152965
71FoxO signaling pathway_Homo sapiens_hsa040680.44353715
72Fat digestion and absorption_Homo sapiens_hsa049750.44132607
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44111834
74Renin-angiotensin system_Homo sapiens_hsa046140.43801072
75Tryptophan metabolism_Homo sapiens_hsa003800.43244948
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.42862085
77Starch and sucrose metabolism_Homo sapiens_hsa005000.42603160
78AMPK signaling pathway_Homo sapiens_hsa041520.42500497
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.41993840
80Herpes simplex infection_Homo sapiens_hsa051680.40987054
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.39282642
82HIF-1 signaling pathway_Homo sapiens_hsa040660.39214032
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38851819
84N-Glycan biosynthesis_Homo sapiens_hsa005100.38495225
85Steroid biosynthesis_Homo sapiens_hsa001000.38415303
86Endometrial cancer_Homo sapiens_hsa052130.35639300
87Osteoclast differentiation_Homo sapiens_hsa043800.35331055
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.34836156
89Toxoplasmosis_Homo sapiens_hsa051450.34396639
90mTOR signaling pathway_Homo sapiens_hsa041500.34077072
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.33806315
92Inositol phosphate metabolism_Homo sapiens_hsa005620.33576163
93Oocyte meiosis_Homo sapiens_hsa041140.33127055
94Viral myocarditis_Homo sapiens_hsa054160.32981348
95Type II diabetes mellitus_Homo sapiens_hsa049300.32967709
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32409639
97Proteoglycans in cancer_Homo sapiens_hsa052050.31769012
98Antigen processing and presentation_Homo sapiens_hsa046120.31738073
99Complement and coagulation cascades_Homo sapiens_hsa046100.30829921
100Malaria_Homo sapiens_hsa051440.30800332
101Vitamin B6 metabolism_Homo sapiens_hsa007500.30632707
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30569144
103Hematopoietic cell lineage_Homo sapiens_hsa046400.30319580
104Fatty acid metabolism_Homo sapiens_hsa012120.30258147
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29499379
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29480609
107Hepatitis B_Homo sapiens_hsa051610.29474822
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28968963
109ErbB signaling pathway_Homo sapiens_hsa040120.28800417
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28695527
111HTLV-I infection_Homo sapiens_hsa051660.28595617
112Tight junction_Homo sapiens_hsa045300.28404517
113Histidine metabolism_Homo sapiens_hsa003400.27706436
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.27440382
115PPAR signaling pathway_Homo sapiens_hsa033200.27214837
116VEGF signaling pathway_Homo sapiens_hsa043700.26947856
117Legionellosis_Homo sapiens_hsa051340.26408281
118Leishmaniasis_Homo sapiens_hsa051400.26349231
119Allograft rejection_Homo sapiens_hsa053300.26198821
120Autoimmune thyroid disease_Homo sapiens_hsa053200.26179934
121Propanoate metabolism_Homo sapiens_hsa006400.25881106
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25765211
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25261054
124Butanoate metabolism_Homo sapiens_hsa006500.25037198
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24965665
126Measles_Homo sapiens_hsa051620.24858981
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24280395
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24179220
129Sulfur relay system_Homo sapiens_hsa041220.23496340
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22714750
131Platelet activation_Homo sapiens_hsa046110.22305426
132Fatty acid biosynthesis_Homo sapiens_hsa000610.21544575
133Fatty acid elongation_Homo sapiens_hsa000620.21487100
134Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21344400
135Influenza A_Homo sapiens_hsa051640.21210244
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20528582
137Galactose metabolism_Homo sapiens_hsa000520.20152187
138Melanoma_Homo sapiens_hsa052180.18665975
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18454476
140DNA replication_Homo sapiens_hsa030300.18092597
141Staphylococcus aureus infection_Homo sapiens_hsa051500.17727166
142Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.17370532
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17202284
144Glycosaminoglycan degradation_Homo sapiens_hsa005310.17155225
145Acute myeloid leukemia_Homo sapiens_hsa052210.17123907
146Insulin signaling pathway_Homo sapiens_hsa049100.17065849
147Peroxisome_Homo sapiens_hsa041460.16972561
148Renal cell carcinoma_Homo sapiens_hsa052110.16899748
149Arginine and proline metabolism_Homo sapiens_hsa003300.16842341
150Mismatch repair_Homo sapiens_hsa034300.16768822
151Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16762944
152AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.16667481
153Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16123191
154Thyroid cancer_Homo sapiens_hsa052160.15829238
155TNF signaling pathway_Homo sapiens_hsa046680.15774331
156Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15555662
157Prolactin signaling pathway_Homo sapiens_hsa049170.13875682

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