HIST1H1D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome organization (GO:0034723)9.49262776
2DNA replication-dependent nucleosome assembly (GO:0006335)9.49262776
3regulation of histone H3-K9 methylation (GO:0051570)7.78626403
4* nucleosome assembly (GO:0006334)6.59046690
5* chromatin assembly (GO:0031497)6.46834512
6nuclear pore complex assembly (GO:0051292)6.26198521
7nuclear pore organization (GO:0006999)6.02880802
8DNA unwinding involved in DNA replication (GO:0006268)5.74904983
9* nucleosome organization (GO:0034728)5.72912622
10* protein-DNA complex assembly (GO:0065004)5.52453807
11protein localization to kinetochore (GO:0034501)5.38562826
12mitotic chromosome condensation (GO:0007076)5.36456606
13antibacterial humoral response (GO:0019731)5.30561528
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.25908984
15* chromatin assembly or disassembly (GO:0006333)5.23480755
16innate immune response in mucosa (GO:0002227)5.02778312
17* protein-DNA complex subunit organization (GO:0071824)4.97346310
18antimicrobial humoral response (GO:0019730)4.96220750
19sister chromatid segregation (GO:0000819)4.95240364
20regulation of gene silencing (GO:0060968)4.74904090
21pore complex assembly (GO:0046931)4.71307647
22protein localization to chromosome, centromeric region (GO:0071459)4.57100898
23negative regulation of histone methylation (GO:0031061)4.54577298
24regulation of posttranscriptional gene silencing (GO:0060147)4.52631123
25regulation of gene silencing by miRNA (GO:0060964)4.52631123
26regulation of gene silencing by RNA (GO:0060966)4.52631123
27folic acid-containing compound biosynthetic process (GO:0009396)4.34963620
28mitotic sister chromatid segregation (GO:0000070)4.34867799
29chromatin remodeling at centromere (GO:0031055)4.24744544
30CENP-A containing nucleosome assembly (GO:0034080)4.19072660
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.18046735
32DNA replication initiation (GO:0006270)4.16419227
33DNA duplex unwinding (GO:0032508)4.10809618
34DNA geometric change (GO:0032392)4.10711929
35protein K6-linked ubiquitination (GO:0085020)4.07004619
36dosage compensation (GO:0007549)3.96009939
37positive regulation of chromosome segregation (GO:0051984)3.95345999
38mitotic nuclear envelope disassembly (GO:0007077)3.91916675
39regulation of centriole replication (GO:0046599)3.90199380
40positive regulation of mitotic sister chromatid separation (GO:1901970)3.89247117
41positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.89247117
42positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.89247117
43mucosal immune response (GO:0002385)3.88222127
44DNA ligation (GO:0006266)3.80754969
45V(D)J recombination (GO:0033151)3.80080584
46DNA replication-independent nucleosome assembly (GO:0006336)3.79359894
47DNA replication-independent nucleosome organization (GO:0034724)3.79359894
48membrane disassembly (GO:0030397)3.73073390
49nuclear envelope disassembly (GO:0051081)3.73073390
50negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.72474545
51mitotic sister chromatid cohesion (GO:0007064)3.71460871
52positive regulation of histone methylation (GO:0031062)3.70744707
53IMP biosynthetic process (GO:0006188)3.67783205
54kinetochore organization (GO:0051383)3.66973934
55pre-miRNA processing (GO:0031054)3.65994735
56DNA strand elongation involved in DNA replication (GO:0006271)3.65976949
57organ or tissue specific immune response (GO:0002251)3.65781883
58chromosome condensation (GO:0030261)3.64840544
59regulation of sister chromatid cohesion (GO:0007063)3.64776128
60regulation of translational fidelity (GO:0006450)3.59764908
61regulation of DNA endoreduplication (GO:0032875)3.57191141
62regulation of centrosome cycle (GO:0046605)3.51900441
63non-recombinational repair (GO:0000726)3.50331667
64double-strand break repair via nonhomologous end joining (GO:0006303)3.50331667
65translesion synthesis (GO:0019985)3.49740288
66DNA topological change (GO:0006265)3.47069097
67histone exchange (GO:0043486)3.46166788
68DNA strand elongation (GO:0022616)3.45972295
69mitotic recombination (GO:0006312)3.45950559
70meiotic chromosome segregation (GO:0045132)3.44587130
71histone lysine demethylation (GO:0070076)3.44236773
72regulation of RNA export from nucleus (GO:0046831)3.39970052
73mature B cell differentiation involved in immune response (GO:0002313)3.39919304
74kinetochore assembly (GO:0051382)3.38271658
75protoporphyrinogen IX metabolic process (GO:0046501)3.34432265
76DNA conformation change (GO:0071103)3.34307071
77telomere maintenance via semi-conservative replication (GO:0032201)3.34182940
78histone demethylation (GO:0016577)3.32415882
79regulation of centrosome duplication (GO:0010824)3.32232173
80regulation of spindle organization (GO:0090224)3.28927474
81IMP metabolic process (GO:0046040)3.27975186
82attachment of spindle microtubules to kinetochore (GO:0008608)3.27446445
83nucleotide-excision repair, DNA gap filling (GO:0006297)3.27184899
84regulation of helicase activity (GO:0051095)3.26406243
85B cell receptor signaling pathway (GO:0050853)3.26131255
86DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.23900088
87viral mRNA export from host cell nucleus (GO:0046784)3.20822707
88postreplication repair (GO:0006301)3.20634389
89regulation of histone methylation (GO:0031060)3.20255677
90regulation of megakaryocyte differentiation (GO:0045652)3.18978400
91microtubule depolymerization (GO:0007019)3.18412777
92regulation of mitotic spindle organization (GO:0060236)3.15505452
93protein localization to chromosome (GO:0034502)3.14957552
94regulation of chromosome segregation (GO:0051983)3.14676789
95negative regulation of DNA repair (GO:0045738)3.11645735
96ATP-dependent chromatin remodeling (GO:0043044)3.10716771
97DNA packaging (GO:0006323)3.10346202
98spindle assembly involved in mitosis (GO:0090307)3.10253014
99mitotic metaphase plate congression (GO:0007080)3.07647621
100telomere maintenance via recombination (GO:0000722)3.07335117
101telomere maintenance via telomere lengthening (GO:0010833)3.04791290
102somatic cell DNA recombination (GO:0016444)3.04611504
103somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.04611504
104metaphase plate congression (GO:0051310)3.04569046
105regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.04204714
106telomere maintenance (GO:0000723)3.03311134
107negative regulation of B cell apoptotic process (GO:0002903)3.03297352
108DNA synthesis involved in DNA repair (GO:0000731)3.00980925
109chromosome segregation (GO:0007059)2.99959377
110determination of adult lifespan (GO:0008340)2.99279044
111telomere organization (GO:0032200)2.99182756
112maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.99142171
113defense response to Gram-positive bacterium (GO:0050830)2.98854995
114mitotic DNA integrity checkpoint (GO:0044774)2.98785634
115pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.96460028
116protein dealkylation (GO:0008214)2.96263025
117protein demethylation (GO:0006482)2.96263025
118ribosomal small subunit biogenesis (GO:0042274)2.95486438
119protoporphyrinogen IX biosynthetic process (GO:0006782)2.94848621
120negative regulation of chromosome segregation (GO:0051985)2.94118950
121mature B cell differentiation (GO:0002335)2.89089222
122positive regulation of B cell differentiation (GO:0045579)2.87939924
123negative T cell selection (GO:0043383)2.87589626
124negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84866163
125negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.84866163
126negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84866163
127negative regulation of mitotic sister chromatid separation (GO:2000816)2.84866163
128negative regulation of sister chromatid segregation (GO:0033046)2.84866163
129regulation of sister chromatid segregation (GO:0033045)2.84717757
130regulation of mitotic sister chromatid separation (GO:0010965)2.84717757
131regulation of mitotic sister chromatid segregation (GO:0033047)2.84717757
132establishment of integrated proviral latency (GO:0075713)2.82719311
133regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.82639484
134regulation of mitotic metaphase/anaphase transition (GO:0030071)2.82639484
135somatic diversification of immune receptors (GO:0002200)2.80321482
136mitotic spindle assembly checkpoint (GO:0007094)2.78707115
137maturation of SSU-rRNA (GO:0030490)2.78211603
138regulation of B cell receptor signaling pathway (GO:0050855)2.77463582
139regulation of double-strand break repair via homologous recombination (GO:0010569)2.75247669
140spindle assembly checkpoint (GO:0071173)2.74872396
141negative thymic T cell selection (GO:0045060)2.74516189
142replication fork processing (GO:0031297)2.74274306
143establishment of viral latency (GO:0019043)2.73843044
144T cell migration (GO:0072678)2.70740374
145deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.70417409

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.88736523
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.57816068
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.29021438
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.08599390
5* SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.15225612
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.09768682
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.43597035
8* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.23394967
9* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17653795
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.06193225
11* E2F1_21310950_ChIP-Seq_MCF-7_Human2.00217336
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse15.9081655
13* SOX2_16153702_ChIP-ChIP_HESCs_Human1.94162579
14IRF1_19129219_ChIP-ChIP_H3396_Human1.89260585
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.85957820
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83545168
17CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.78354941
18MYC_18555785_ChIP-Seq_MESCs_Mouse1.77108930
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.73496705
20* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.61100654
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.59461647
22SOX2_18555785_ChIP-Seq_MESCs_Mouse1.59141194
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.58069880
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55178818
25RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52018277
26* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48507613
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46618606
28TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45874119
29AR_21909140_ChIP-Seq_LNCAP_Human1.42482900
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41037287
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40026798
32HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.38604705
33* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.37824415
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.37703741
35* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36879489
36HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.33285051
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30364124
38POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27213046
39TCF3_18692474_ChIP-Seq_MESCs_Mouse1.24179956
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22857181
41* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22790197
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.22255514
43* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19015258
44* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17016791
45* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16034414
46VDR_23849224_ChIP-Seq_CD4+_Human1.14641102
47* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.14235451
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12997542
49* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10677898
50* NANOG_16153702_ChIP-ChIP_HESCs_Human1.10627304
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10542583
52EST1_17652178_ChIP-ChIP_JURKAT_Human1.09418799
53ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08388829
54MYC_22102868_ChIP-Seq_BL_Human1.07650277
55ELK1_19687146_ChIP-ChIP_HELA_Human1.04881654
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04283519
57MYC_18940864_ChIP-ChIP_HL60_Human1.04275731
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03550219
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01364452
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99974542
61MYB_26560356_Chip-Seq_TH2_Human0.95859939
62MAF_26560356_Chip-Seq_TH1_Human0.95413306
63JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.93261918
64* MYB_26560356_Chip-Seq_TH1_Human0.91999178
65ETS1_20019798_ChIP-Seq_JURKAT_Human0.91956733
66* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89725721
67* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.88469011
68RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87908510
69SCL_19346495_ChIP-Seq_HPC-7_Human0.87582043
70MYC_18358816_ChIP-ChIP_MESCs_Mouse0.86454665
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84447330
72* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.83797316
73* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.83709318
74STAT4_19710469_ChIP-ChIP_TH1__Mouse0.83103446
75GATA1_22025678_ChIP-Seq_K562_Human0.82502914
76GABP_17652178_ChIP-ChIP_JURKAT_Human0.82323317
77SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.80919284
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.80802388
79XRN2_22483619_ChIP-Seq_HELA_Human0.80584401
80MYCN_18555785_ChIP-Seq_MESCs_Mouse0.80024887
81NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.78467277
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.75491527
83* FOXP3_21729870_ChIP-Seq_TREG_Human0.73868509
84* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.73847681
85ZFX_18555785_ChIP-Seq_MESCs_Mouse0.73437022
86THAP11_20581084_ChIP-Seq_MESCs_Mouse0.73079214
87* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.72785012
88* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72654098
89MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.72599846
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.71964107
91VDR_21846776_ChIP-Seq_THP-1_Human0.71808835
92* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.71327055
93DCP1A_22483619_ChIP-Seq_HELA_Human0.70838951
94NANOG_21062744_ChIP-ChIP_HESCs_Human0.70622790
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.70503778
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.70390377
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.70376780
98NOTCH1_21737748_ChIP-Seq_TLL_Human0.69154010
99* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.67707793
100* SALL4_22934838_ChIP-ChIP_CD34+_Human0.67527490
101TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.67026031
102SRF_21415370_ChIP-Seq_HL-1_Mouse0.67000514
103FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.66626481
104RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.66104222
105* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.65612002
106MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.65517064
107SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.64565424
108PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.64486490
109NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.64406039
110HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.63654296
111CREB1_15753290_ChIP-ChIP_HEK293T_Human0.62956556
112CIITA_25753668_ChIP-Seq_RAJI_Human0.62877197
113TCF3_18692474_ChIP-Seq_MEFs_Mouse0.61490872
114SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.61193452
115KDM5A_27292631_Chip-Seq_BREAST_Human0.59289310
116ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.58605006
117NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.58217668
118SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.58151605
119GATA1_19941826_ChIP-Seq_K562_Human0.57197505
120* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.56842557
121MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.56386676
122* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.55991586
123NANOG_18692474_ChIP-Seq_MESCs_Mouse0.54526547
124KLF4_18555785_ChIP-Seq_MESCs_Mouse0.54160255
125TCF7_22412390_ChIP-Seq_EML_Mouse0.53870501
126KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.53602196

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.81765487
2MP0003111_abnormal_nucleus_morphology4.14819540
3MP0010307_abnormal_tumor_latency3.95574031
4MP0003077_abnormal_cell_cycle3.57146343
5MP0003693_abnormal_embryo_hatching3.30640222
6MP0010352_gastrointestinal_tract_polyps3.15172236
7MP0003763_abnormal_thymus_physiology3.10288923
8MP0004957_abnormal_blastocyst_morpholog3.05870389
9MP0008057_abnormal_DNA_replication3.05096012
10MP0003705_abnormal_hypodermis_morpholog2.99321279
11MP0010234_abnormal_vibrissa_follicle2.82586960
12MP0005076_abnormal_cell_differentiation2.68491075
13MP0009697_abnormal_copulation2.46959045
14MP0001835_abnormal_antigen_presentation2.40921130
15MP0003656_abnormal_erythrocyte_physiolo2.39245462
16MP0003123_paternal_imprinting2.35652196
17MP0008058_abnormal_DNA_repair2.30105834
18MP0000350_abnormal_cell_proliferation2.28079399
19MP0000685_abnormal_immune_system2.25428274
20MP0001730_embryonic_growth_arrest2.15983616
21MP0004147_increased_porphyrin_level2.11566405
22MP0003121_genomic_imprinting2.07067932
23MP0008007_abnormal_cellular_replicative2.03836035
24MP0008932_abnormal_embryonic_tissue1.98104483
25MP0005671_abnormal_response_to1.96712979
26MP0005645_abnormal_hypothalamus_physiol1.93157204
27MP0004197_abnormal_fetal_growth/weight/1.92626297
28MP0006054_spinal_hemorrhage1.89169869
29MP0002086_abnormal_extraembryonic_tissu1.86259265
30MP0001800_abnormal_humoral_immune1.84770495
31MP0002084_abnormal_developmental_patter1.78873253
32MP0004808_abnormal_hematopoietic_stem1.76717006
33MP0001697_abnormal_embryo_size1.74426580
34MP0001672_abnormal_embryogenesis/_devel1.70326504
35MP0005380_embryogenesis_phenotype1.70326504
36MP0000490_abnormal_crypts_of1.68587581
37MP0002085_abnormal_embryonic_tissue1.67284057
38MP0000372_irregular_coat_pigmentation1.62923277
39MP0002396_abnormal_hematopoietic_system1.61999989
40MP0008877_abnormal_DNA_methylation1.56830036
41MP0002080_prenatal_lethality1.56017890
42MP0000537_abnormal_urethra_morphology1.49704294
43MP0005075_abnormal_melanosome_morpholog1.49323369
44MP0003984_embryonic_growth_retardation1.48443890
45MP0002088_abnormal_embryonic_growth/wei1.47077439
46MP0002877_abnormal_melanocyte_morpholog1.47026862
47MP0002019_abnormal_tumor_incidence1.38475714
48MP0001293_anophthalmia1.37944853
49MP0002009_preneoplasia1.35386441
50MP0000716_abnormal_immune_system1.34210119
51MP0003718_maternal_effect1.31736800
52MP0002420_abnormal_adaptive_immunity1.30044036
53MP0001819_abnormal_immune_cell1.27321204
54MP0003890_abnormal_embryonic-extraembry1.26736737
55MP0002166_altered_tumor_susceptibility1.22939971
56MP0003567_abnormal_fetal_cardiomyocyte1.22436996
57MP0002452_abnormal_antigen_presenting1.22309702
58MP0003937_abnormal_limbs/digits/tail_de1.21224627
59MP0000313_abnormal_cell_death1.21158373
60MP0005000_abnormal_immune_tolerance1.20867783
61MP0006035_abnormal_mitochondrial_morpho1.19733911
62MP0003787_abnormal_imprinting1.19425524
63MP0003566_abnormal_cell_adhesion1.19124258
64MP0000703_abnormal_thymus_morphology1.18469003
65MP0003786_premature_aging1.17537946
66MP0000733_abnormal_muscle_development1.16522721
67MP0004264_abnormal_extraembryonic_tissu1.15568295
68MP0004381_abnormal_hair_follicle1.14563639
69MP0002092_abnormal_eye_morphology1.14058577
70MP0002697_abnormal_eye_size1.13900260
71MP0002723_abnormal_immune_serum1.11230783
72MP0005623_abnormal_meninges_morphology1.09046318
73MP0006292_abnormal_olfactory_placode1.07996982
74MP0001661_extended_life_span1.07802115
75MP0001915_intracranial_hemorrhage1.07322253
76MP0002111_abnormal_tail_morphology1.07102805
77MP0008770_decreased_survivor_rate1.06758593
78MP0001790_abnormal_immune_system1.04446461
79MP0005387_immune_system_phenotype1.04446461
80MP0009703_decreased_birth_body1.03156884
81MP0001849_ear_inflammation1.03069102
82MP0010678_abnormal_skin_adnexa1.02911383
83MP0002722_abnormal_immune_system1.02175132
84MP0000358_abnormal_cell_content/1.00475354
85MP0002006_tumorigenesis1.00013135
86MP0002398_abnormal_bone_marrow0.98641820
87MP0000569_abnormal_digit_pigmentation0.98034063
88MP0009053_abnormal_anal_canal0.97794359
89MP0005083_abnormal_biliary_tract0.95649167
90MP0003300_gastrointestinal_ulcer0.94816049
91MP0000015_abnormal_ear_pigmentation0.94042634
92MP0002095_abnormal_skin_pigmentation0.92249930
93MP0000371_diluted_coat_color0.92234657
94MP0005220_abnormal_exocrine_pancreas0.91314562
95MP0010030_abnormal_orbit_morphology0.91116803
96MP0000689_abnormal_spleen_morphology0.90310021
97MP0005397_hematopoietic_system_phenotyp0.88421147
98MP0001545_abnormal_hematopoietic_system0.88421147
99MP0002925_abnormal_cardiovascular_devel0.88253339
100MP0005023_abnormal_wound_healing0.87737493
101MP0000465_gastrointestinal_hemorrhage0.85936495
102MP0004185_abnormal_adipocyte_glucose0.85369423
103MP0002075_abnormal_coat/hair_pigmentati0.84998297
104MP0005621_abnormal_cell_physiology0.84621941
105MP0009672_abnormal_birth_weight0.82293735
106MP0003119_abnormal_digestive_system0.82241925
107MP0005384_cellular_phenotype0.79886151
108MP0005025_abnormal_response_to0.79699185
109MP0001286_abnormal_eye_development0.79523810
110MP0006072_abnormal_retinal_apoptosis0.79061886
111MP0009333_abnormal_splenocyte_physiolog0.75568661
112MP0003806_abnormal_nucleotide_metabolis0.74415219
113MP0001119_abnormal_female_reproductive0.74409111
114MP0002160_abnormal_reproductive_system0.73802358
115MP0003453_abnormal_keratinocyte_physiol0.73475069
116MP0002163_abnormal_gland_morphology0.73133098
117MP0005501_abnormal_skin_physiology0.73100730
118MP0008438_abnormal_cutaneous_collagen0.72697200
119MP0003861_abnormal_nervous_system0.72662341
120MP0003941_abnormal_skin_development0.72061746
121MP0001727_abnormal_embryo_implantation0.71557624
122MP0000477_abnormal_intestine_morphology0.71236294
123MP0005647_abnormal_sex_gland0.69786473
124MP0005464_abnormal_platelet_physiology0.69193805
125MP0000432_abnormal_head_morphology0.69079429
126MP0003183_abnormal_peptide_metabolism0.68756596
127MP0003091_abnormal_cell_migration0.68753578
128MP0005310_abnormal_salivary_gland0.68099209
129MP0002429_abnormal_blood_cell0.67422757
130MP0009278_abnormal_bone_marrow0.66631472
131MP0005171_absent_coat_pigmentation0.63554204
132MP0003448_altered_tumor_morphology0.62658280
133MP0004947_skin_inflammation0.62334518
134MP0000428_abnormal_craniofacial_morphol0.60153604
135MP0000383_abnormal_hair_follicle0.59934951
136MP0000266_abnormal_heart_morphology0.59465224
137MP0001929_abnormal_gametogenesis0.57850399
138MP0001145_abnormal_male_reproductive0.57829618
139MP0004233_abnormal_muscle_weight0.57272229
140MP0001919_abnormal_reproductive_system0.56880994
141MP0009931_abnormal_skin_appearance0.56838989
142MP0001191_abnormal_skin_condition0.56696546
143MP0003866_abnormal_defecation0.55812292
144MP0008260_abnormal_autophagy0.55354734

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)6.58609110
2IgA deficiency (HP:0002720)5.62378328
3Poikilocytosis (HP:0004447)4.50165854
4Agammaglobulinemia (HP:0004432)4.33937192
5Colitis (HP:0002583)4.22976234
6B lymphocytopenia (HP:0010976)3.75761069
7Chromsome breakage (HP:0040012)3.74009691
8Hypochromic microcytic anemia (HP:0004840)3.68632906
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.59380484
10Ependymoma (HP:0002888)3.58739335
11Abnormality of B cell number (HP:0010975)3.48630109
12Cellulitis (HP:0100658)3.35420961
13Gastrointestinal stroma tumor (HP:0100723)3.28686864
14Acanthocytosis (HP:0001927)3.23529109
15Abnormality of chromosome stability (HP:0003220)3.22415142
16Recurrent bronchitis (HP:0002837)3.21590821
17Impulsivity (HP:0100710)3.10359101
18Autoimmune hemolytic anemia (HP:0001890)3.09953011
19Astrocytoma (HP:0009592)3.08062203
20Abnormality of the astrocytes (HP:0100707)3.08062203
21Medulloblastoma (HP:0002885)3.03277969
22Cutaneous melanoma (HP:0012056)3.02748478
23Short 4th metacarpal (HP:0010044)2.97606332
24Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.97606332
25Nephroblastoma (Wilms tumor) (HP:0002667)2.96177551
26Recurrent sinusitis (HP:0011108)2.94721721
27Reticulocytopenia (HP:0001896)2.93912589
28Lymphopenia (HP:0001888)2.92254577
29Abnormality of the labia minora (HP:0012880)2.88717993
30Recurrent viral infections (HP:0004429)2.86097171
31Acute lymphatic leukemia (HP:0006721)2.85986929
32Rhabdomyosarcoma (HP:0002859)2.83562410
33Volvulus (HP:0002580)2.83448541
34Abnormality of cells of the lymphoid lineage (HP:0012140)2.78005542
35Embryonal renal neoplasm (HP:0011794)2.76886124
36Abnormality of reticulocytes (HP:0004312)2.76139663
37Prostate neoplasm (HP:0100787)2.72117903
38Panhypogammaglobulinemia (HP:0003139)2.70289866
39Lymphoma (HP:0002665)2.69791167
40Hypopigmentation of the fundus (HP:0007894)2.68901022
41Agnosia (HP:0010524)2.66982348
42Neoplasm of the oral cavity (HP:0100649)2.66863411
43Reticulocytosis (HP:0001923)2.66142392
44Abnormality of the heme biosynthetic pathway (HP:0010472)2.65405590
45Colon cancer (HP:0003003)2.64632008
46Clubbing of toes (HP:0100760)2.63569408
47IgG deficiency (HP:0004315)2.62785083
48Selective tooth agenesis (HP:0001592)2.62567374
49Basal cell carcinoma (HP:0002671)2.59709557
50Inflammation of the large intestine (HP:0002037)2.57971739
51Biliary tract neoplasm (HP:0100574)2.57555081
52Glioma (HP:0009733)2.55363018
53Sandal gap (HP:0001852)2.55288437
54Cortical dysplasia (HP:0002539)2.55233356
55Microvesicular hepatic steatosis (HP:0001414)2.55054356
56Chronic diarrhea (HP:0002028)2.54681833
57Birth length less than 3rd percentile (HP:0003561)2.54367073
58Cafe-au-lait spot (HP:0000957)2.52052380
59Combined immunodeficiency (HP:0005387)2.50597365
60Abnormality of the prostate (HP:0008775)2.46661391
61Gastrointestinal inflammation (HP:0004386)2.44690370
62Dry hair (HP:0011359)2.43672252
63High pitched voice (HP:0001620)2.42881347
64Severe combined immunodeficiency (HP:0004430)2.41819540
65Prominent nose (HP:0000448)2.39434466
66Abnormal number of erythroid precursors (HP:0012131)2.37164308
67Abnormality of the fingertips (HP:0001211)2.35171452
68Deviation of the thumb (HP:0009603)2.33993287
69Aplasia/Hypoplasia of the uvula (HP:0010293)2.32800477
70Meningitis (HP:0001287)2.32018130
71T lymphocytopenia (HP:0005403)2.29513652
72Heterotopia (HP:0002282)2.27971464
73Abnormality of T cells (HP:0002843)2.27795680
74Abnormality of T cell physiology (HP:0011840)2.26567409
75Increased nuchal translucency (HP:0010880)2.26273213
76Malignant gastrointestinal tract tumors (HP:0006749)2.25545196
77Gastrointestinal carcinoma (HP:0002672)2.25545196
78Neoplasm of striated muscle (HP:0009728)2.25159784
79Proximal placement of thumb (HP:0009623)2.24649317
80Ulnar bowing (HP:0003031)2.23654608
81Subacute progressive viral hepatitis (HP:0006572)2.22657091
82Spastic diplegia (HP:0001264)2.18974384
83Leukopenia (HP:0001882)2.14540826
84Duodenal stenosis (HP:0100867)2.13876594
85Small intestinal stenosis (HP:0012848)2.13876594
86Abnormality of DNA repair (HP:0003254)2.13009224
87Meckel diverticulum (HP:0002245)2.12516827
88Carpal bone hypoplasia (HP:0001498)2.11404262
89Freckling (HP:0001480)2.09391502
90Abnormality of T cell number (HP:0011839)2.07975388
91Cellular immunodeficiency (HP:0005374)2.07590650
92Viral hepatitis (HP:0006562)2.06929531
93Ectopic kidney (HP:0000086)2.06097303
94Myelodysplasia (HP:0002863)2.05881555
95Aplasia/Hypoplasia of the sacrum (HP:0008517)2.05828819
96Amaurosis fugax (HP:0100576)2.04829919
97Recurrent pneumonia (HP:0006532)2.03708045
98Abnormality of the 4th metacarpal (HP:0010012)2.03680487
99Erythema (HP:0010783)2.02973608
100Missing ribs (HP:0000921)2.02749946
101Abnormality of the ileum (HP:0001549)2.02501886
102Patellar aplasia (HP:0006443)2.01409044
103Abnormality of the carotid arteries (HP:0005344)1.96972544
104Sloping forehead (HP:0000340)1.96864069
105Squamous cell carcinoma (HP:0002860)1.96856462
106Insomnia (HP:0100785)1.96591125
107Osteomyelitis (HP:0002754)1.96461147
108Abnormality of the preputium (HP:0100587)1.96117583
109Skull defect (HP:0001362)1.96108760
11011 pairs of ribs (HP:0000878)1.94646284
111Mediastinal lymphadenopathy (HP:0100721)1.94179272
112Recurrent bacterial skin infections (HP:0005406)1.92666563
113Renovascular hypertension (HP:0100817)1.92369674
114Absent frontal sinuses (HP:0002688)1.92007259
115Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.91136643
116Ovarian neoplasm (HP:0100615)1.90703293
117Thyroiditis (HP:0100646)1.89188605
118Absent radius (HP:0003974)1.88557346
119Onycholysis (HP:0001806)1.88236106
120Truncal obesity (HP:0001956)1.87407472
121Recurrent lower respiratory tract infections (HP:0002783)1.86643737
122Abnormality of the duodenum (HP:0002246)1.86013671
123Pallor (HP:0000980)1.85572091
124Neoplasm of the pancreas (HP:0002894)1.85347353
125Neoplasm of the adrenal cortex (HP:0100641)1.83872914
126Acute myeloid leukemia (HP:0004808)1.83600526
127Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.83193952
128Absent thumb (HP:0009777)1.82085418
129Deep philtrum (HP:0002002)1.82058607
130Hepatitis (HP:0012115)1.81645146
131Cutis marmorata (HP:0000965)1.80365304
132Aplasia/Hypoplasia of the patella (HP:0006498)1.79875719
133Cleft eyelid (HP:0000625)1.79680795
134Multiple enchondromatosis (HP:0005701)1.79217359
135Hypochromic anemia (HP:0001931)1.78896668
136Arteriovenous malformation (HP:0100026)1.77179454
137Abnormal number of incisors (HP:0011064)1.77039716
138Cerebral aneurysm (HP:0004944)1.76745284
139Long eyelashes (HP:0000527)1.76635681
140Large earlobe (HP:0009748)1.76283647
141Abnormality of chromosome segregation (HP:0002916)1.73863641
142Embryonal neoplasm (HP:0002898)1.72822139
143Fibrous tissue neoplasm (HP:0012316)1.72817020
144Short humerus (HP:0005792)1.72591480
145Bronchitis (HP:0012387)1.72484760
146Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.71972146
147Neoplasm of the small intestine (HP:0100833)1.71796018
148Aplasia involving forearm bones (HP:0009822)1.71741489
149Absent forearm bone (HP:0003953)1.71741489
150Abnormality of the calcaneus (HP:0008364)1.70245903
151Abnormality of cells of the erythroid lineage (HP:0012130)1.69914431
152Recurrent fungal infections (HP:0002841)1.69866097
153Intestinal polyposis (HP:0200008)1.68461437
154Abnormal delayed hypersensitivity skin test (HP:0002963)1.68426274
155Partial agenesis of the corpus callosum (HP:0001338)1.68073494
156Atresia of the external auditory canal (HP:0000413)1.67649000
157Intestinal polyp (HP:0005266)1.66948127
158Duplicated collecting system (HP:0000081)1.66470635
159Aplasia/Hypoplasia of the thymus (HP:0010515)1.66273013
160Chronic otitis media (HP:0000389)1.66215207
161High anterior hairline (HP:0009890)1.66136411
162Hematochezia (HP:0002573)1.65483236
163Abnormality of oral frenula (HP:0000190)1.65033431
164Short thumb (HP:0009778)1.64834943
165Uterine neoplasm (HP:0010784)1.64159577
166Esophageal atresia (HP:0002032)1.64102493
167Aplasia/Hypoplasia of the sternum (HP:0006714)1.63216676

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.63227367
2ZAK6.25933267
3VRK13.45179244
4CDC73.19457438
5STK42.99277126
6RPS6KA52.77921653
7CDK92.06422698
8MAP3K102.03129411
9SCYL22.00817304
10EEF2K2.00652307
11CDK121.99899363
12NEK21.92158760
13PKN21.80192131
14WEE11.69496189
15EPHA21.65989701
16PIM11.63270006
17AURKB1.59447194
18CHEK21.57196346
19RPS6KB21.56521961
20MAP3K81.55090994
21SRPK11.51858571
22TAF11.48340205
23SMG11.34921426
24BUB11.28465542
25TTK1.20937465
26VRK21.18914817
27DYRK31.17207752
28BTK1.16314665
29DAPK31.12635879
30PBK1.08107383
31NEK11.06252338
32TTN1.05754359
33ATR1.04510123
34PKN11.04040019
35FLT31.03967855
36PLK10.97325224
37EIF2AK10.93563859
38CDK40.92665374
39AURKA0.87806496
40GRK60.87113055
41ACVR1B0.86037111
42CAMK1D0.84850745
43MELK0.83213731
44NUAK10.82918134
45STK100.81739118
46PASK0.81256387
47SYK0.81070652
48PIK3CG0.79609497
49CHEK10.77622045
50CCNB10.76782211
51BCKDK0.76424992
52ATM0.73581647
53PLK30.72969948
54FRK0.72860421
55KDR0.70160669
56BRD40.67848187
57CDK60.67421339
58DYRK1B0.66117824
59TEC0.65223847
60MAP4K10.63609887
61AKT20.63358493
62BRAF0.61062738
63CDK70.59521803
64* CDK20.57163432
65STK30.54625706
66NLK0.54029849
67MAP3K130.52629680
68FGFR20.50790292
69LATS10.50326556
70CSNK1D0.49970062
71IKBKE0.49532412
72BRSK20.48832332
73TGFBR10.48595451
74PIM20.47593643
75CDK10.47068834
76MET0.46115929
77PRKAA10.45246827
78LRRK20.43941288
79BLK0.41889304
80MTOR0.41690164
81LYN0.38141143
82TRIB30.36352316
83KIT0.36163844
84PTK60.36030029
85CDK80.35330630
86MAP3K140.35271585
87PAK40.35008089
88RAF10.33083830
89NEK90.32733780
90ALK0.32612674
91CSNK1G10.32373294
92NME20.32369979
93CDK190.31486285
94PRKDC0.31369848
95JAK20.31171154
96CSNK1G30.29823465
97IRAK40.29588285
98EIF2AK30.29573241
99BMX0.29116570
100KSR10.29023077
101MAPK110.28890042
102BRSK10.28619516
103STK160.28534568
104PDGFRA0.28482816
105CSNK1A1L0.27339539
106PAK10.27304944
107ROCK10.26552638
108IKBKB0.25965812
109TSSK60.25189707
110MAPK140.25017391
111TESK20.24795963
112EIF2AK20.24635915
113RPS6KA40.23883773
114RPS6KB10.23242210
115RIPK10.23066360
116TRPM70.22898246
117MAPKAPK50.22864936
118PAK20.22352927
119TBK10.22157972
120MAP4K20.21789811
121AKT10.21534968
122CAMK40.20624187
123MARK30.20174383
124MAP3K40.19566664
125TAOK30.19373330
126PRKCQ0.18716708
127FGR0.18406957
128ITK0.17937778
129LCK0.16349327
130MKNK10.15698454
131CSNK2A20.15456115
132MAPKAPK30.14543814
133PRKCI0.14167499
134FGFR30.13945171
135MAP2K70.13618762
136CLK10.13568024
137CSF1R0.13492451
138FGFR10.13406311
139PLK40.12940881
140MAPK10.12650771
141MST40.12596971
142RPS6KC10.12094606
143RPS6KL10.12094606
144MAP2K30.11757617
145PRPF4B0.11547528
146HCK0.11371999
147CAMK1G0.11273432

Predicted pathways (KEGG)

RankGene SetZ-score
1Alcoholism_Homo sapiens_hsa050346.49724775
2Viral carcinogenesis_Homo sapiens_hsa052033.39993986
3DNA replication_Homo sapiens_hsa030302.75756855
4Mismatch repair_Homo sapiens_hsa034302.50825881
5One carbon pool by folate_Homo sapiens_hsa006702.04705334
6Systemic lupus erythematosus_Homo sapiens_hsa0532211.3863866
7Cell cycle_Homo sapiens_hsa041101.97507101
8Transcriptional misregulation in cancer_Homo sapiens_hsa052021.95501494
9Non-homologous end-joining_Homo sapiens_hsa034501.69595665
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59220341
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.51109031
12RNA transport_Homo sapiens_hsa030131.50776702
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.50702951
14Fanconi anemia pathway_Homo sapiens_hsa034601.50355029
15Nucleotide excision repair_Homo sapiens_hsa034201.50088751
16Base excision repair_Homo sapiens_hsa034101.39816378
17Homologous recombination_Homo sapiens_hsa034401.36889740
18Allograft rejection_Homo sapiens_hsa053301.33901048
19Spliceosome_Homo sapiens_hsa030401.27149357
20Asthma_Homo sapiens_hsa053101.23800539
21Autoimmune thyroid disease_Homo sapiens_hsa053201.23787567
22Graft-versus-host disease_Homo sapiens_hsa053321.15978132
23p53 signaling pathway_Homo sapiens_hsa041151.12070414
24MicroRNAs in cancer_Homo sapiens_hsa052061.05157997
25mRNA surveillance pathway_Homo sapiens_hsa030151.03341628
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92780310
27Ribosome_Homo sapiens_hsa030100.90739125
28Small cell lung cancer_Homo sapiens_hsa052220.88544252
29Type I diabetes mellitus_Homo sapiens_hsa049400.86727964
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76672915
31Chronic myeloid leukemia_Homo sapiens_hsa052200.75857670
32Selenocompound metabolism_Homo sapiens_hsa004500.74103381
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73195844
34HTLV-I infection_Homo sapiens_hsa051660.65354190
35Non-small cell lung cancer_Homo sapiens_hsa052230.63663951
36Leishmaniasis_Homo sapiens_hsa051400.60181070
37Pyrimidine metabolism_Homo sapiens_hsa002400.59461381
38Bladder cancer_Homo sapiens_hsa052190.58573975
39RNA degradation_Homo sapiens_hsa030180.58254892
40Oocyte meiosis_Homo sapiens_hsa041140.58122913
41mTOR signaling pathway_Homo sapiens_hsa041500.57843066
42Lysine degradation_Homo sapiens_hsa003100.55209571
43Sulfur relay system_Homo sapiens_hsa041220.51371758
44Antigen processing and presentation_Homo sapiens_hsa046120.50808249
45Herpes simplex infection_Homo sapiens_hsa051680.50688369
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50001725
47Epstein-Barr virus infection_Homo sapiens_hsa051690.48949071
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48943498
49Central carbon metabolism in cancer_Homo sapiens_hsa052300.48927260
50Apoptosis_Homo sapiens_hsa042100.47917051
51Colorectal cancer_Homo sapiens_hsa052100.46820984
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44280002
53Pancreatic cancer_Homo sapiens_hsa052120.41937641
54RNA polymerase_Homo sapiens_hsa030200.41084768
55Prostate cancer_Homo sapiens_hsa052150.39837392
56Hepatitis B_Homo sapiens_hsa051610.39632606
57Proteasome_Homo sapiens_hsa030500.39487999
58TGF-beta signaling pathway_Homo sapiens_hsa043500.39040757
59Glioma_Homo sapiens_hsa052140.38735449
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37777099
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37240147
62Proteoglycans in cancer_Homo sapiens_hsa052050.34903835
63Hippo signaling pathway_Homo sapiens_hsa043900.34873563
64FoxO signaling pathway_Homo sapiens_hsa040680.34828729
65Adherens junction_Homo sapiens_hsa045200.34741644
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33122916
67Melanoma_Homo sapiens_hsa052180.32541681
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.31712572
69Biosynthesis of amino acids_Homo sapiens_hsa012300.31523126
70Thyroid cancer_Homo sapiens_hsa052160.30809072
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30606691
72Endometrial cancer_Homo sapiens_hsa052130.29731107
73B cell receptor signaling pathway_Homo sapiens_hsa046620.29721552
74Basal cell carcinoma_Homo sapiens_hsa052170.27757866
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26278539
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26246821
77Carbon metabolism_Homo sapiens_hsa012000.25896589
78Pathways in cancer_Homo sapiens_hsa052000.25852954
79Tight junction_Homo sapiens_hsa045300.24409178
80Viral myocarditis_Homo sapiens_hsa054160.24097123
81Hematopoietic cell lineage_Homo sapiens_hsa046400.23292497
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23287423
83Notch signaling pathway_Homo sapiens_hsa043300.23044580
84Basal transcription factors_Homo sapiens_hsa030220.22374628
85Focal adhesion_Homo sapiens_hsa045100.21995291
86Measles_Homo sapiens_hsa051620.21828682
87HIF-1 signaling pathway_Homo sapiens_hsa040660.21759497
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21165907
89T cell receptor signaling pathway_Homo sapiens_hsa046600.20562487
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.20182450
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19517198
92Renin-angiotensin system_Homo sapiens_hsa046140.18572608
93AMPK signaling pathway_Homo sapiens_hsa041520.18519103
94Nitrogen metabolism_Homo sapiens_hsa009100.18384018
95Inositol phosphate metabolism_Homo sapiens_hsa005620.18032098
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17551216
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.15912116
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15292688
99Purine metabolism_Homo sapiens_hsa002300.13890344
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13630969
101Influenza A_Homo sapiens_hsa051640.13510450
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.13503289
103Pentose phosphate pathway_Homo sapiens_hsa000300.13444866
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13262428
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13227415
106Platelet activation_Homo sapiens_hsa046110.12766874
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.12640465
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.12610464
109Huntingtons disease_Homo sapiens_hsa050160.12204738
110Legionellosis_Homo sapiens_hsa051340.12093204
111Parkinsons disease_Homo sapiens_hsa050120.11573249
112ECM-receptor interaction_Homo sapiens_hsa045120.11059439
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.10946125
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.10923439
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.09509776
116Toxoplasmosis_Homo sapiens_hsa051450.09360484
117Primary immunodeficiency_Homo sapiens_hsa053400.08881977
118Staphylococcus aureus infection_Homo sapiens_hsa051500.08767663
119Acute myeloid leukemia_Homo sapiens_hsa052210.08686577
120Vitamin B6 metabolism_Homo sapiens_hsa007500.08496989
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.08038816
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.06689112
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.06446100
124Hepatitis C_Homo sapiens_hsa051600.06066659
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.06041837
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.05840192
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.03739568
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.03122599
129N-Glycan biosynthesis_Homo sapiens_hsa005100.02837202
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.02385145

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