HIST1H1PS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of thymocyte apoptotic process (GO:0070244)5.08888103
2rRNA methylation (GO:0031167)3.98337200
3regulation of memory T cell differentiation (GO:0043380)3.70920084
4positive regulation of endothelial cell differentiation (GO:0045603)3.60804253
5hematopoietic stem cell differentiation (GO:0060218)3.51477102
6rRNA modification (GO:0000154)3.49654075
7positive regulation of granulocyte differentiation (GO:0030854)3.47245992
8purinergic nucleotide receptor signaling pathway (GO:0035590)3.42747436
9detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.41298733
10definitive hemopoiesis (GO:0060216)3.38577423
11innate immune response in mucosa (GO:0002227)3.37519910
12thrombin receptor signaling pathway (GO:0070493)3.33979090
13DNA double-strand break processing (GO:0000729)3.31143960
14regulation of platelet aggregation (GO:0090330)3.30021216
15leukocyte migration involved in inflammatory response (GO:0002523)3.25360264
16regulation of megakaryocyte differentiation (GO:0045652)3.15766758
17meiotic chromosome segregation (GO:0045132)3.14289152
18response to hydroperoxide (GO:0033194)3.14211674
19regulation of B cell apoptotic process (GO:0002902)3.13492042
20regulation of thymocyte apoptotic process (GO:0070243)3.11807720
21mitochondrial DNA replication (GO:0006264)3.11449293
22regulation of platelet activation (GO:0010543)3.09936210
23regulation of inositol phosphate biosynthetic process (GO:0010919)3.07042842
24negative regulation of B cell apoptotic process (GO:0002903)3.05341858
25S-adenosylmethionine metabolic process (GO:0046500)3.04968656
26negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.98974369
27regulation of viral entry into host cell (GO:0046596)2.98727849
28regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.98635824
29organelle membrane fusion (GO:0090174)2.97572923
30regulation of integrin activation (GO:0033623)2.96820773
31pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.96650120
32positive regulation of protein kinase C signaling (GO:0090037)2.96143734
33DNA deamination (GO:0045006)2.95462395
34negative regulation of T cell apoptotic process (GO:0070233)2.94812711
35adenosine metabolic process (GO:0046085)2.92760722
36autophagic vacuole fusion (GO:0000046)2.90111820
37tryptophan metabolic process (GO:0006568)2.89210951
38regulation of germinal center formation (GO:0002634)2.87346009
39positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.86785127
40granulocyte differentiation (GO:0030851)2.84123724
41mucosal immune response (GO:0002385)2.83686223
42positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.82495679
43replication fork processing (GO:0031297)2.81629191
44regulation of histone H3-K4 methylation (GO:0051569)2.79707534
45G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.78927764
46negative regulation of viral entry into host cell (GO:0046597)2.78914716
47organ or tissue specific immune response (GO:0002251)2.77922244
48regulation of histone H3-K9 methylation (GO:0051570)2.77099881
49mast cell degranulation (GO:0043303)2.75622885
50mast cell activation involved in immune response (GO:0002279)2.75622885
51negative regulation of lymphocyte apoptotic process (GO:0070229)2.74790131
52tryptophan catabolic process (GO:0006569)2.73161783
53indole-containing compound catabolic process (GO:0042436)2.73161783
54indolalkylamine catabolic process (GO:0046218)2.73161783
55kynurenine metabolic process (GO:0070189)2.71748228
56negative regulation of Rho protein signal transduction (GO:0035024)2.70635064
57blood coagulation, intrinsic pathway (GO:0007597)2.70466167
58neutrophil activation involved in immune response (GO:0002283)2.70334418
59interferon-gamma secretion (GO:0072643)2.69226349
60negative regulation of homotypic cell-cell adhesion (GO:0034111)2.68905654
61regulation of endothelial cell differentiation (GO:0045601)2.67475190
62positive regulation of protein homodimerization activity (GO:0090073)2.65801903
63regulation of penile erection (GO:0060405)2.65571505
64poly(A)+ mRNA export from nucleus (GO:0016973)2.65545704
65positive regulation of erythrocyte differentiation (GO:0045648)2.65093580
66protein neddylation (GO:0045116)2.63775637
67mucosal-associated lymphoid tissue development (GO:0048537)2.62810481
68Peyers patch development (GO:0048541)2.62810481
69cellular biogenic amine catabolic process (GO:0042402)2.62752599
70amine catabolic process (GO:0009310)2.62752599
71germinal center formation (GO:0002467)2.57934301
72negative regulation of T-helper cell differentiation (GO:0045623)2.57864601
73negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.57864601
74mitotic G2/M transition checkpoint (GO:0044818)2.57406378
75mannosylation (GO:0097502)2.57123593
76mitotic G2 DNA damage checkpoint (GO:0007095)2.56889983
77xenobiotic catabolic process (GO:0042178)2.54489799
78detection of chemical stimulus involved in sensory perception (GO:0050907)2.53496228
79indolalkylamine metabolic process (GO:0006586)2.52141548
80regulation of triglyceride catabolic process (GO:0010896)2.51095023
81negative regulation of stress fiber assembly (GO:0051497)2.51054887
82leukocyte degranulation (GO:0043299)2.49869837
83tyrosine metabolic process (GO:0006570)2.46438402
84sulfation (GO:0051923)2.45505516
85DNA replication checkpoint (GO:0000076)2.45122406
86base-excision repair, AP site formation (GO:0006285)2.44611538
87nucleosome assembly (GO:0006334)2.44589012
88negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.44265495
89negative regulation of platelet activation (GO:0010544)2.41032551
90antibacterial humoral response (GO:0019731)2.39504546
91regulation of hypersensitivity (GO:0002883)2.39210644
92aromatic amino acid family catabolic process (GO:0009074)2.37574634
93positive regulation of toll-like receptor signaling pathway (GO:0034123)2.36163651
94fusion of sperm to egg plasma membrane (GO:0007342)2.36053533
95B cell mediated immunity (GO:0019724)2.35987722
96synapsis (GO:0007129)2.34649708
97deoxyribose phosphate catabolic process (GO:0046386)2.34293635
98deoxyribonucleotide catabolic process (GO:0009264)2.34132199
99triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.33988834
100detection of light stimulus involved in sensory perception (GO:0050962)2.33346937

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.27797460
2EGR1_23403033_ChIP-Seq_LIVER_Mouse3.97368370
3SCL_19346495_ChIP-Seq_HPC-7_Human3.73691214
4E2F7_22180533_ChIP-Seq_HELA_Human3.71853269
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.67929579
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.88666437
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.66423247
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.64798156
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.55611226
10SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.23940377
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13370574
12ESR1_15608294_ChIP-ChIP_MCF-7_Human2.06233127
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.02831551
14LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.02713130
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.95718015
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.92481001
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.90463440
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.90089659
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89743737
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79028440
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.78177440
22HOXB4_20404135_ChIP-ChIP_EML_Mouse1.77408663
23GATA2_19941826_ChIP-Seq_K562_Human1.76835768
24GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.76407519
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.75706021
26GATA1_19941826_ChIP-Seq_K562_Human1.75676413
27HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.73406070
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.71254625
29SPI1_23127762_ChIP-Seq_K562_Human1.68677967
30VDR_23849224_ChIP-Seq_CD4+_Human1.59460125
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.55356614
32MYB_26560356_Chip-Seq_TH1_Human1.54941854
33LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.54273371
34ELK1_19687146_ChIP-ChIP_HELA_Human1.51051348
35SPI1_23547873_ChIP-Seq_NB4_Human1.46942056
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44952401
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44637300
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44203574
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43913422
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.43025234
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41769824
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.41548400
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.40731265
44NCOR1_26117541_ChIP-Seq_K562_Human1.40140401
45GATA1_22383799_ChIP-Seq_G1ME_Mouse1.39962438
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38869048
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.36853556
48GATA3_21878914_ChIP-Seq_MCF-7_Human1.35667916
49GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.33640190
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.30066370
51DCP1A_22483619_ChIP-Seq_HELA_Human1.29967451
52MYB_26560356_Chip-Seq_TH2_Human1.28851918
53ETS1_22383799_ChIP-Seq_G1ME_Mouse1.28516631
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28305106
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27667306
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25615015
57ER_23166858_ChIP-Seq_MCF-7_Human1.23697461
58GATA3_27048872_Chip-Seq_THYMUS_Human1.22263531
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22159880
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21783966
61TDRD3_21172665_ChIP-Seq_MCF-7_Human1.21746427
62GATA1_22025678_ChIP-Seq_K562_Human1.20799128
63FOXP3_21729870_ChIP-Seq_TREG_Human1.20341678
64VDR_24763502_ChIP-Seq_THP-1_Human1.19041203
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18842748
66GATA3_26560356_Chip-Seq_TH2_Human1.18816904
67ZNF274_21170338_ChIP-Seq_K562_Hela1.18381596
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18263592
69MAF_26560356_Chip-Seq_TH1_Human1.17662930
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16862835
71UTX_26944678_Chip-Seq_JUKART_Human1.16498297
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.16313841
73KDM5A_27292631_Chip-Seq_BREAST_Human1.14687344
74FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11968797
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11058256
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.10104997
77PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09484531
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09131414
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.07955264
80JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06504213
81IRF1_19129219_ChIP-ChIP_H3396_Human1.06282161
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06216541
83IGF1R_20145208_ChIP-Seq_DFB_Human1.04703256
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.03251648
85VDR_21846776_ChIP-Seq_THP-1_Human1.00965821
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97953372
87STAT1_20625510_ChIP-Seq_HELA_Human0.97530393
88ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97487610
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97334662
90ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96592236
91E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94863598
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94425796
93CIITA_25753668_ChIP-Seq_RAJI_Human0.93285059
94IRF8_27001747_Chip-Seq_BMDM_Mouse0.91560769
95HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91176515
96SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90108455
97MAF_26560356_Chip-Seq_TH2_Human0.89587121
98GATA6_25053715_ChIP-Seq_YYC3_Human0.88684506
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88336000
100NANOG_20526341_ChIP-Seq_ESCs_Human0.87002842

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology4.86093156
2MP0008004_abnormal_stomach_pH4.03470139
3MP0009697_abnormal_copulation3.19965498
4MP0003724_increased_susceptibility_to2.73176033
5MP0002132_abnormal_respiratory_system2.53031494
6MP0010094_abnormal_chromosome_stability2.51479719
7MP0003693_abnormal_embryo_hatching2.41258034
8MP0000015_abnormal_ear_pigmentation2.23208506
9MP0003136_yellow_coat_color2.13803416
10MP0001835_abnormal_antigen_presentation2.12399389
11MP0001545_abnormal_hematopoietic_system2.08667805
12MP0005397_hematopoietic_system_phenotyp2.08667805
13MP0004381_abnormal_hair_follicle2.07427127
14MP0000465_gastrointestinal_hemorrhage2.05101586
15MP0008058_abnormal_DNA_repair2.03626383
16MP0005174_abnormal_tail_pigmentation1.77177245
17MP0002166_altered_tumor_susceptibility1.72320507
18MP0004808_abnormal_hematopoietic_stem1.72168830
19MP0003111_abnormal_nucleus_morphology1.69388644
20MP0004147_increased_porphyrin_level1.67104812
21MP0005171_absent_coat_pigmentation1.65291218
22MP0000013_abnormal_adipose_tissue1.63540020
23MP0009278_abnormal_bone_marrow1.63534894
24MP0003646_muscle_fatigue1.61297326
25MP0008775_abnormal_heart_ventricle1.56901855
26MP0005075_abnormal_melanosome_morpholog1.51268222
27MP0001661_extended_life_span1.50143861
28MP0002396_abnormal_hematopoietic_system1.47424357
29MP0005083_abnormal_biliary_tract1.45627013
30MP0003656_abnormal_erythrocyte_physiolo1.43997933
31MP0003806_abnormal_nucleotide_metabolis1.39886302
32MP0008057_abnormal_DNA_replication1.38756268
33MP0002653_abnormal_ependyma_morphology1.37974733
34MP0008007_abnormal_cellular_replicative1.37438929
35MP0002398_abnormal_bone_marrow1.37082466
36MP0005410_abnormal_fertilization1.35168545
37MP0005084_abnormal_gallbladder_morpholo1.31743180
38MP0008872_abnormal_physiological_respon1.31638335
39MP0003195_calcinosis1.31104422
40MP0002148_abnormal_hypersensitivity_rea1.29917629
41MP0010307_abnormal_tumor_latency1.29486907
42MP0006036_abnormal_mitochondrial_physio1.28966026
43MP0003077_abnormal_cell_cycle1.28554882
44MP0002006_tumorigenesis1.27476132
45MP0008875_abnormal_xenobiotic_pharmacok1.27253657
46MP0003763_abnormal_thymus_physiology1.26460237
47MP0000689_abnormal_spleen_morphology1.26358292
48MP0003786_premature_aging1.25988049
49MP0010234_abnormal_vibrissa_follicle1.25891655
50MP0005167_abnormal_blood-brain_barrier1.24644363
51MP0004084_abnormal_cardiac_muscle1.22986669
52MP0002019_abnormal_tumor_incidence1.21757726
53MP0001800_abnormal_humoral_immune1.18018585
54MP0003828_pulmonary_edema1.16989488
55MP0002722_abnormal_immune_system1.16165944
56MP0005000_abnormal_immune_tolerance1.12893049
57MP0000372_irregular_coat_pigmentation1.12597514
58MP0004947_skin_inflammation1.10162283
59MP0010368_abnormal_lymphatic_system1.09170663
60MP0002723_abnormal_immune_serum1.06245707
61MP0005646_abnormal_pituitary_gland1.05718651
62MP0002452_abnormal_antigen_presenting1.03184734
63MP0004957_abnormal_blastocyst_morpholog1.03172294
64MP0002876_abnormal_thyroid_physiology1.02410599
65MP0003718_maternal_effect0.99570062
66MP0002429_abnormal_blood_cell0.99351297
67MP0000703_abnormal_thymus_morphology0.99227106
68MP0002420_abnormal_adaptive_immunity0.97890507
69MP0001819_abnormal_immune_cell0.96463009
70MP0003252_abnormal_bile_duct0.95967822
71MP0002419_abnormal_innate_immunity0.95620004
72MP0006035_abnormal_mitochondrial_morpho0.93833609
73MP0000716_abnormal_immune_system0.92638022
74MP0000685_abnormal_immune_system0.92274022
75MP0002138_abnormal_hepatobiliary_system0.91723845
76MP0004484_altered_response_of0.90463215
77MP0003172_abnormal_lysosome_physiology0.89880920
78MP0009763_increased_sensitivity_to0.89652502
79MP0000371_diluted_coat_color0.88125909
80MP0001879_abnormal_lymphatic_vessel0.87156569
81MP0000230_abnormal_systemic_arterial0.86427738
82MP0008995_early_reproductive_senescence0.85702542
83MP0001929_abnormal_gametogenesis0.85305721
84MP0001485_abnormal_pinna_reflex0.83970811
85MP0008961_abnormal_basal_metabolism0.83755062
86MP0002638_abnormal_pupillary_reflex0.82053664
87MP0002095_abnormal_skin_pigmentation0.81416581
88MP0005671_abnormal_response_to0.81149859
89MP0003436_decreased_susceptibility_to0.81106310
90MP0005025_abnormal_response_to0.80158077
91MP0002160_abnormal_reproductive_system0.78760639
92MP0001502_abnormal_circadian_rhythm0.77890295
93MP0001881_abnormal_mammary_gland0.76231677
94MP0010329_abnormal_lipoprotein_level0.75516762
95MP0005647_abnormal_sex_gland0.75223242
96MP0003186_abnormal_redox_activity0.74823686
97MP0000358_abnormal_cell_content/0.73385803
98MP0001845_abnormal_inflammatory_respons0.72912077
99MP0003950_abnormal_plasma_membrane0.72607785
100MP0000313_abnormal_cell_death0.70825859

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)6.18595317
2Prolonged bleeding time (HP:0003010)6.13974564
3Increased mean platelet volume (HP:0011877)5.16425483
4Menorrhagia (HP:0000132)4.96525338
5Abnormal platelet volume (HP:0011876)4.86549079
6Purpura (HP:0000979)3.93246305
7Epistaxis (HP:0000421)3.83630212
8Panhypogammaglobulinemia (HP:0003139)3.43306333
9Autoimmune hemolytic anemia (HP:0001890)3.22141714
10Abnormal platelet function (HP:0011869)3.20781064
11Impaired platelet aggregation (HP:0003540)3.20781064
12B lymphocytopenia (HP:0010976)3.09159703
13Abnormality of B cell number (HP:0010975)3.05251990
14Acanthocytosis (HP:0001927)3.03517467
15Absent thumb (HP:0009777)3.02826506
16Poikilocytosis (HP:0004447)2.99290580
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.98457134
18Generalized hypopigmentation of hair (HP:0011358)2.97223740
19Gingival bleeding (HP:0000225)2.91448539
20Abnormality of the heme biosynthetic pathway (HP:0010472)2.86995664
21Eosinophilia (HP:0001880)2.83172331
22Granulocytopenia (HP:0001913)2.80633033
23Abnormality of lateral ventricle (HP:0030047)2.75097306
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.66171345
25Chromsome breakage (HP:0040012)2.65196436
26Paralysis (HP:0003470)2.57672985
27Clubbing of toes (HP:0100760)2.56522973
28Abnormality of chromosome stability (HP:0003220)2.55313040
29Acute lymphatic leukemia (HP:0006721)2.54777523
30Myelodysplasia (HP:0002863)2.52889628
31Abnormality of the preputium (HP:0100587)2.51828316
32Generalized aminoaciduria (HP:0002909)2.51100806
33Albinism (HP:0001022)2.50447638
34Tinnitus (HP:0000360)2.44734513
35Ectopic kidney (HP:0000086)2.43790001
36Carpal bone hypoplasia (HP:0001498)2.42296421
37Duplicated collecting system (HP:0000081)2.42051029
38Aplastic anemia (HP:0001915)2.41865014
39Congenital stationary night blindness (HP:0007642)2.41675636
40Abnormality of iron homeostasis (HP:0011031)2.40778822
41Meckel diverticulum (HP:0002245)2.38801195
42Nausea (HP:0002018)2.36387170
43Abnormality of the ileum (HP:0001549)2.33789113
44Dyschromatopsia (HP:0007641)2.33139034
45Thyroiditis (HP:0100646)2.30153569
46Recurrent fungal infections (HP:0002841)2.26110594
47Abnormality of transition element cation homeostasis (HP:0011030)2.25841911
48Renal Fanconi syndrome (HP:0001994)2.21988447
49Hypoplasia of the fovea (HP:0007750)2.20579990
50Aplasia/Hypoplasia of the fovea (HP:0008060)2.20579990
51Abnormality of the renal collecting system (HP:0004742)2.18912252
52Chronic otitis media (HP:0000389)2.16372395
53Recurrent viral infections (HP:0004429)2.14286265
54Severe combined immunodeficiency (HP:0004430)2.09747599
55Decreased central vision (HP:0007663)2.09653143
56Progressive muscle weakness (HP:0003323)2.08965522
57Hyperlipoproteinemia (HP:0010980)2.07549899
58Duodenal stenosis (HP:0100867)2.07389786
59Small intestinal stenosis (HP:0012848)2.07389786
60Bone marrow hypocellularity (HP:0005528)2.05233343
61Ileus (HP:0002595)2.05138903
62Squamous cell carcinoma (HP:0002860)2.05081404
63Fair hair (HP:0002286)2.04773985
64Autoimmune thrombocytopenia (HP:0001973)2.04343177
65Acute myeloid leukemia (HP:0004808)2.02637999
66Leukocytosis (HP:0001974)2.02555731
67Hyperthyroidism (HP:0000836)2.02348571
68Short thumb (HP:0009778)2.00002569
69Abnormality of pyrimidine metabolism (HP:0004353)1.98369673
70Renal cortical cysts (HP:0000803)1.97876717
71Polydipsia (HP:0001959)1.97540179
72Abnormal drinking behavior (HP:0030082)1.97540179
73Abnormality of the fovea (HP:0000493)1.95823033
74Hypophosphatemic rickets (HP:0004912)1.95768127
75Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.95723458
76Prominent nose (HP:0000448)1.95260994
77Elevated erythrocyte sedimentation rate (HP:0003565)1.93726904
78Hypergonadotropic hypogonadism (HP:0000815)1.91010253
79Aplasia/Hypoplasia of the thymus (HP:0010515)1.90949147
80Abnormality of the renal cortex (HP:0011035)1.89264302
81Attenuation of retinal blood vessels (HP:0007843)1.87809949
82Abnormality of eosinophils (HP:0001879)1.86560554
83Abnormality of the carotid arteries (HP:0005344)1.84849880
84Combined immunodeficiency (HP:0005387)1.82941316
85Lip pit (HP:0100267)1.81707063
86Ocular albinism (HP:0001107)1.80278187
87Generalized hypopigmentation (HP:0007513)1.80095145
88Encephalitis (HP:0002383)1.79354354
89Acute hepatic failure (HP:0006554)1.79119214
90White forelock (HP:0002211)1.79091703
91Abnormal delayed hypersensitivity skin test (HP:0002963)1.76987017
92Bruising susceptibility (HP:0000978)1.76870476
93Cutaneous melanoma (HP:0012056)1.76114320
94Pancytopenia (HP:0001876)1.74799323
95Abnormality of sulfur amino acid metabolism (HP:0004339)1.71287026
96Abnormal rod and cone electroretinograms (HP:0008323)1.70734964
97Abnormality of dental color (HP:0011073)1.69644681
98Hypoplasia of the thymus (HP:0000778)1.64372868
99Reduced antithrombin III activity (HP:0001976)1.63561813
100Recurrent cutaneous fungal infections (HP:0011370)1.63272717

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK6.08238066
2TLK16.00436262
3TAOK34.36181698
4MST43.13715226
5RIPK42.78971321
6FRK2.20670224
7MARK32.15240578
8NUAK12.08620211
9VRK12.07045514
10CCNB12.05716287
11AKT31.93965414
12CAMK1D1.86449588
13TEC1.83591090
14BRSK21.72256140
15MAP4K21.61118654
16PDK21.59109407
17BTK1.56931780
18MAP3K141.49506067
19GRK11.48839892
20FLT31.42387819
21BMPR1B1.37416470
22CAMKK21.36936940
23IKBKB1.34974497
24PIK3CG1.17506295
25RPS6KA51.16604110
26MAP2K31.16216128
27WEE11.14001536
28SYK1.09939257
29CAMK1G1.09614725
30PBK1.09595186
31STK161.05090695
32DYRK31.04364183
33BUB11.04010503
34BMX1.00330898
35ZAP701.00222209
36ACVR1B0.96734098
37GRK60.96272771
38CDK120.96233260
39PRKCQ0.94065423
40MAPK110.91788133
41STK40.89886826
42ADRBK20.89133353
43ATR0.83842482
44BLK0.82010003
45MYLK0.79832467
46PIM10.76557875
47EIF2AK30.76328413
48PTK2B0.76147156
49BMPR20.75781107
50MAP3K50.75776754
51MUSK0.75485542
52MAP3K30.68246330
53TTK0.67033873
54STK30.63599758
55JAK20.63307581
56NEK20.61756765
57PAK10.61581820
58EIF2AK10.61268750
59NLK0.60999358
60PKN10.60583132
61AURKA0.59657543
62STK240.59547508
63CDC70.56497629
64CHEK20.55235531
65TNK20.54632922
66MAP2K10.53026686
67KIT0.52074602
68MAPKAPK30.51364332
69HCK0.48322553
70MAPK150.47210842
71MELK0.45100973
72RAF10.43240561
73LYN0.41573592
74JAK30.40178469
75CSNK1G30.39709434
76PHKG20.38530383
77PHKG10.38530383
78PINK10.37368133
79DAPK30.36834433
80IKBKE0.36743519
81ADRBK10.36525886
82LATS10.36363199
83PRKAA10.36336103
84MAPK120.36304380
85ITK0.33723260
86PRKCI0.33534441
87GRK50.33425117
88CSNK1G10.33159674
89ATM0.31819703
90ILK0.31351711
91MAP2K20.30806041
92MAP3K10.30509204
93PLK10.30017428
94CSNK1A1L0.27783675
95HIPK20.27674530
96PIM20.26748201
97MAP4K10.26544643
98PLK30.26326150
99AURKB0.26222604
100IRAK10.25622113

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053225.92841090
2Alcoholism_Homo sapiens_hsa050344.08351399
3Fanconi anemia pathway_Homo sapiens_hsa034602.95995080
4Platelet activation_Homo sapiens_hsa046112.34733178
5Olfactory transduction_Homo sapiens_hsa047402.28779614
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.27558103
7SNARE interactions in vesicular transport_Homo sapiens_hsa041302.11965344
8RNA polymerase_Homo sapiens_hsa030202.10064370
9Viral carcinogenesis_Homo sapiens_hsa052032.07189165
10Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.96157556
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.91379014
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.81959412
13Homologous recombination_Homo sapiens_hsa034401.78369042
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75933876
15Steroid hormone biosynthesis_Homo sapiens_hsa001401.67747313
16Chemical carcinogenesis_Homo sapiens_hsa052041.67417014
17Primary immunodeficiency_Homo sapiens_hsa053401.63737993
18Base excision repair_Homo sapiens_hsa034101.56119688
19Transcriptional misregulation in cancer_Homo sapiens_hsa052021.55538980
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51580083
21Hematopoietic cell lineage_Homo sapiens_hsa046401.43444270
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.37870175
23Selenocompound metabolism_Homo sapiens_hsa004501.36612831
24B cell receptor signaling pathway_Homo sapiens_hsa046621.34203841
25Mismatch repair_Homo sapiens_hsa034301.32107699
26DNA replication_Homo sapiens_hsa030301.31576094
27Nitrogen metabolism_Homo sapiens_hsa009101.31264935
28Caffeine metabolism_Homo sapiens_hsa002321.27415821
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23977220
30Glutathione metabolism_Homo sapiens_hsa004801.21681313
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21257389
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.21231982
33Basal transcription factors_Homo sapiens_hsa030221.15823780
34Arachidonic acid metabolism_Homo sapiens_hsa005901.15460429
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14291996
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.11116218
37Linoleic acid metabolism_Homo sapiens_hsa005911.09213654
38Cell cycle_Homo sapiens_hsa041101.04777294
39Retinol metabolism_Homo sapiens_hsa008301.04575512
40Pyrimidine metabolism_Homo sapiens_hsa002401.03668131
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00593323
42Dorso-ventral axis formation_Homo sapiens_hsa043200.98809010
43p53 signaling pathway_Homo sapiens_hsa041150.96697161
44Lysine degradation_Homo sapiens_hsa003100.96161775
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94093031
46Butanoate metabolism_Homo sapiens_hsa006500.92645295
47Purine metabolism_Homo sapiens_hsa002300.91414429
48Staphylococcus aureus infection_Homo sapiens_hsa051500.86586564
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.84451697
50One carbon pool by folate_Homo sapiens_hsa006700.83681366
51Phototransduction_Homo sapiens_hsa047440.74181967
52Acute myeloid leukemia_Homo sapiens_hsa052210.73255628
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.72034688
54Measles_Homo sapiens_hsa051620.71313658
55Herpes simplex infection_Homo sapiens_hsa051680.68294971
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67545557
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65605584
58Tryptophan metabolism_Homo sapiens_hsa003800.63099201
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63063356
60Sphingolipid metabolism_Homo sapiens_hsa006000.62596279
61Legionellosis_Homo sapiens_hsa051340.62066894
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61214574
63RNA degradation_Homo sapiens_hsa030180.59283668
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.58067624
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57923928
66Non-small cell lung cancer_Homo sapiens_hsa052230.54902333
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.54163480
68Leishmaniasis_Homo sapiens_hsa051400.53891660
69Apoptosis_Homo sapiens_hsa042100.53555643
70Non-homologous end-joining_Homo sapiens_hsa034500.51326861
71Asthma_Homo sapiens_hsa053100.50688018
72T cell receptor signaling pathway_Homo sapiens_hsa046600.49930686
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49527748
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48322933
75Glycerolipid metabolism_Homo sapiens_hsa005610.46999078
76Oocyte meiosis_Homo sapiens_hsa041140.46176576
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45000058
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44750261
79TNF signaling pathway_Homo sapiens_hsa046680.43697919
80Tuberculosis_Homo sapiens_hsa051520.43393402
81Osteoclast differentiation_Homo sapiens_hsa043800.42797872
82FoxO signaling pathway_Homo sapiens_hsa040680.42616663
83Allograft rejection_Homo sapiens_hsa053300.42293244
84Tyrosine metabolism_Homo sapiens_hsa003500.42241890
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41825963
86Graft-versus-host disease_Homo sapiens_hsa053320.41495425
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.40820000
88Hepatitis B_Homo sapiens_hsa051610.40600800
89Peroxisome_Homo sapiens_hsa041460.39377107
90Prostate cancer_Homo sapiens_hsa052150.39028900
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.37610007
92Complement and coagulation cascades_Homo sapiens_hsa046100.37431787
93Fatty acid elongation_Homo sapiens_hsa000620.34865927
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29870990
95Fructose and mannose metabolism_Homo sapiens_hsa000510.27417758
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27195568
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27040821
98Small cell lung cancer_Homo sapiens_hsa052220.26047211
99Metabolic pathways_Homo sapiens_hsa011000.24758066
100Chemokine signaling pathway_Homo sapiens_hsa040620.24605509

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