ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of thymocyte apoptotic process (GO:0070244)	5.08888103
2	rRNA methylation (GO:0031167)	3.98337200
3	regulation of memory T cell differentiation (GO:0043380)	3.70920084
4	positive regulation of endothelial cell differentiation (GO:0045603)	3.60804253
5	hematopoietic stem cell differentiation (GO:0060218)	3.51477102
6	rRNA modification (GO:0000154)	3.49654075
7	positive regulation of granulocyte differentiation (GO:0030854)	3.47245992
8	purinergic nucleotide receptor signaling pathway (GO:0035590)	3.42747436
9	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.41298733
10	definitive hemopoiesis (GO:0060216)	3.38577423
11	innate immune response in mucosa (GO:0002227)	3.37519910
12	thrombin receptor signaling pathway (GO:0070493)	3.33979090
13	DNA double-strand break processing (GO:0000729)	3.31143960
14	regulation of platelet aggregation (GO:0090330)	3.30021216
15	leukocyte migration involved in inflammatory response (GO:0002523)	3.25360264
16	regulation of megakaryocyte differentiation (GO:0045652)	3.15766758
17	meiotic chromosome segregation (GO:0045132)	3.14289152
18	response to hydroperoxide (GO:0033194)	3.14211674
19	regulation of B cell apoptotic process (GO:0002902)	3.13492042
20	regulation of thymocyte apoptotic process (GO:0070243)	3.11807720
21	mitochondrial DNA replication (GO:0006264)	3.11449293
22	regulation of platelet activation (GO:0010543)	3.09936210
23	regulation of inositol phosphate biosynthetic process (GO:0010919)	3.07042842
24	negative regulation of B cell apoptotic process (GO:0002903)	3.05341858
25	S-adenosylmethionine metabolic process (GO:0046500)	3.04968656
26	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.98974369
27	regulation of viral entry into host cell (GO:0046596)	2.98727849
28	regulation of hematopoietic progenitor cell differentiation (GO:1901532)	2.98635824
29	organelle membrane fusion (GO:0090174)	2.97572923
30	regulation of integrin activation (GO:0033623)	2.96820773
31	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.96650120
32	positive regulation of protein kinase C signaling (GO:0090037)	2.96143734
33	DNA deamination (GO:0045006)	2.95462395
34	negative regulation of T cell apoptotic process (GO:0070233)	2.94812711
35	adenosine metabolic process (GO:0046085)	2.92760722
36	autophagic vacuole fusion (GO:0000046)	2.90111820
37	tryptophan metabolic process (GO:0006568)	2.89210951
38	regulation of germinal center formation (GO:0002634)	2.87346009
39	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.86785127
40	granulocyte differentiation (GO:0030851)	2.84123724
41	mucosal immune response (GO:0002385)	2.83686223
42	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.82495679
43	replication fork processing (GO:0031297)	2.81629191
44	regulation of histone H3-K4 methylation (GO:0051569)	2.79707534
45	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	2.78927764
46	negative regulation of viral entry into host cell (GO:0046597)	2.78914716
47	organ or tissue specific immune response (GO:0002251)	2.77922244
48	regulation of histone H3-K9 methylation (GO:0051570)	2.77099881
49	mast cell activation involved in immune response (GO:0002279)	2.75622885
50	mast cell degranulation (GO:0043303)	2.75622885
51	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.74790131
52	tryptophan catabolic process (GO:0006569)	2.73161783
53	indole-containing compound catabolic process (GO:0042436)	2.73161783
54	indolalkylamine catabolic process (GO:0046218)	2.73161783
55	kynurenine metabolic process (GO:0070189)	2.71748228
56	negative regulation of Rho protein signal transduction (GO:0035024)	2.70635064
57	blood coagulation, intrinsic pathway (GO:0007597)	2.70466167
58	neutrophil activation involved in immune response (GO:0002283)	2.70334418
59	interferon-gamma secretion (GO:0072643)	2.69226349
60	negative regulation of homotypic cell-cell adhesion (GO:0034111)	2.68905654
61	regulation of endothelial cell differentiation (GO:0045601)	2.67475190
62	positive regulation of protein homodimerization activity (GO:0090073)	2.65801903
63	regulation of penile erection (GO:0060405)	2.65571505
64	poly(A)+ mRNA export from nucleus (GO:0016973)	2.65545704
65	positive regulation of erythrocyte differentiation (GO:0045648)	2.65093580
66	protein neddylation (GO:0045116)	2.63775637
67	mucosal-associated lymphoid tissue development (GO:0048537)	2.62810481
68	Peyers patch development (GO:0048541)	2.62810481
69	cellular biogenic amine catabolic process (GO:0042402)	2.62752599
70	amine catabolic process (GO:0009310)	2.62752599
71	germinal center formation (GO:0002467)	2.57934301
72	negative regulation of T-helper cell differentiation (GO:0045623)	2.57864601
73	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.57864601
74	mitotic G2/M transition checkpoint (GO:0044818)	2.57406378
75	mannosylation (GO:0097502)	2.57123593
76	mitotic G2 DNA damage checkpoint (GO:0007095)	2.56889983
77	xenobiotic catabolic process (GO:0042178)	2.54489799
78	detection of chemical stimulus involved in sensory perception (GO:0050907)	2.53496228
79	indolalkylamine metabolic process (GO:0006586)	2.52141548
80	regulation of triglyceride catabolic process (GO:0010896)	2.51095023
81	negative regulation of stress fiber assembly (GO:0051497)	2.51054887
82	leukocyte degranulation (GO:0043299)	2.49869837
83	tyrosine metabolic process (GO:0006570)	2.46438402
84	sulfation (GO:0051923)	2.45505516
85	DNA replication checkpoint (GO:0000076)	2.45122406
86	base-excision repair, AP site formation (GO:0006285)	2.44611538
87	nucleosome assembly (GO:0006334)	2.44589012
88	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	2.44265495
89	negative regulation of platelet activation (GO:0010544)	2.41032551
90	antibacterial humoral response (GO:0019731)	2.39504546
91	regulation of hypersensitivity (GO:0002883)	2.39210644
92	aromatic amino acid family catabolic process (GO:0009074)	2.37574634
93	positive regulation of toll-like receptor signaling pathway (GO:0034123)	2.36163651
94	fusion of sperm to egg plasma membrane (GO:0007342)	2.36053533
95	B cell mediated immunity (GO:0019724)	2.35987722
96	synapsis (GO:0007129)	2.34649708
97	deoxyribose phosphate catabolic process (GO:0046386)	2.34293635
98	deoxyribonucleotide catabolic process (GO:0009264)	2.34132199
99	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.33988834
100	detection of light stimulus involved in sensory perception (GO:0050962)	2.33346937

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	8.27797460
2	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.97368370
3	SCL_19346495_ChIP-Seq_HPC-7_Human	3.73691214
4	E2F7_22180533_ChIP-Seq_HELA_Human	3.71853269
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.67929579
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.88666437
7	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.66423247
8	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.64798156
9	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.55611226
10	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	2.23940377
11	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.13370574
12	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.06233127
13	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.02831551
14	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.02713130
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.95718015
16	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.92481001
17	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.90463440
18	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.90089659
19	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.89743737
20	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.79028440
21	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.78177440
22	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.77408663
23	GATA2_19941826_ChIP-Seq_K562_Human	1.76835768
24	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.76407519
25	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.75706021
26	GATA1_19941826_ChIP-Seq_K562_Human	1.75676413
27	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.73406070
28	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.71254625
29	SPI1_23127762_ChIP-Seq_K562_Human	1.68677967
30	VDR_23849224_ChIP-Seq_CD4+_Human	1.59460125
31	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.55356614
32	MYB_26560356_Chip-Seq_TH1_Human	1.54941854
33	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.54273371
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.51051348
35	SPI1_23547873_ChIP-Seq_NB4_Human	1.46942056
36	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.44952401
37	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.44637300
38	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.44203574
39	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.43913422
40	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.43025234
41	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.41769824
42	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.41548400
43	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.40731265
44	NCOR1_26117541_ChIP-Seq_K562_Human	1.40140401
45	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.39962438
46	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.38869048
47	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.36853556
48	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.35667916
49	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.33640190
50	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.30066370
51	DCP1A_22483619_ChIP-Seq_HELA_Human	1.29967451
52	MYB_26560356_Chip-Seq_TH2_Human	1.28851918
53	ETS1_22383799_ChIP-Seq_G1ME_Mouse	1.28516631
54	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.28305106
55	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.27667306
56	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.25615015
57	ER_23166858_ChIP-Seq_MCF-7_Human	1.23697461
58	GATA3_27048872_Chip-Seq_THYMUS_Human	1.22263531
59	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.22159880
60	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.21783966
61	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.21746427
62	GATA1_22025678_ChIP-Seq_K562_Human	1.20799128
63	FOXP3_21729870_ChIP-Seq_TREG_Human	1.20341678
64	VDR_24763502_ChIP-Seq_THP-1_Human	1.19041203
65	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.18842748
66	GATA3_26560356_Chip-Seq_TH2_Human	1.18816904
67	ZNF274_21170338_ChIP-Seq_K562_Hela	1.18381596
68	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.18263592
69	MAF_26560356_Chip-Seq_TH1_Human	1.17662930
70	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.16862835
71	UTX_26944678_Chip-Seq_JUKART_Human	1.16498297
72	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.16313841
73	KDM5A_27292631_Chip-Seq_BREAST_Human	1.14687344
74	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.11968797
75	GATA2_22383799_ChIP-Seq_G1ME_Mouse	1.11058256
76	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.10104997
77	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.09484531
78	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.09131414
79	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.07955264
80	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.06504213
81	IRF1_19129219_ChIP-ChIP_H3396_Human	1.06282161
82	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.06216541
83	IGF1R_20145208_ChIP-Seq_DFB_Human	1.04703256
84	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.03251648
85	VDR_21846776_ChIP-Seq_THP-1_Human	1.00965821
86	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.97953372
87	STAT1_20625510_ChIP-Seq_HELA_Human	0.97530393
88	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.97487610
89	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.97334662
90	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.96592236
91	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.94863598
92	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.94425796
93	CIITA_25753668_ChIP-Seq_RAJI_Human	0.93285059
94	IRF8_27001747_Chip-Seq_BMDM_Mouse	0.91560769
95	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.91176515
96	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	0.90108455
97	MAF_26560356_Chip-Seq_TH2_Human	0.89587121
98	GATA6_25053715_ChIP-Seq_YYC3_Human	0.88684506
99	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.88336000
100	NANOG_20526341_ChIP-Seq_ESCs_Human	0.87002842

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005464_abnormal_platelet_physiology	4.86093156
2	MP0008004_abnormal_stomach_pH	4.03470139
3	MP0009697_abnormal_copulation	3.19965498
4	MP0003724_increased_susceptibility_to	2.73176033
5	MP0002132_abnormal_respiratory_system	2.53031494
6	MP0010094_abnormal_chromosome_stability	2.51479719
7	MP0003693_abnormal_embryo_hatching	2.41258034
8	MP0000015_abnormal_ear_pigmentation	2.23208506
9	MP0003136_yellow_coat_color	2.13803416
10	MP0001835_abnormal_antigen_presentation	2.12399389
11	MP0005397_hematopoietic_system_phenotyp	2.08667805
12	MP0001545_abnormal_hematopoietic_system	2.08667805
13	MP0004381_abnormal_hair_follicle	2.07427127
14	MP0000465_gastrointestinal_hemorrhage	2.05101586
15	MP0008058_abnormal_DNA_repair	2.03626383
16	MP0005174_abnormal_tail_pigmentation	1.77177245
17	MP0002166_altered_tumor_susceptibility	1.72320507
18	MP0004808_abnormal_hematopoietic_stem	1.72168830
19	MP0003111_abnormal_nucleus_morphology	1.69388644
20	MP0004147_increased_porphyrin_level	1.67104812
21	MP0005171_absent_coat_pigmentation	1.65291218
22	MP0000013_abnormal_adipose_tissue	1.63540020
23	MP0009278_abnormal_bone_marrow	1.63534894
24	MP0003646_muscle_fatigue	1.61297326
25	MP0008775_abnormal_heart_ventricle	1.56901855
26	MP0005075_abnormal_melanosome_morpholog	1.51268222
27	MP0001661_extended_life_span	1.50143861
28	MP0002396_abnormal_hematopoietic_system	1.47424357
29	MP0005083_abnormal_biliary_tract	1.45627013
30	MP0003656_abnormal_erythrocyte_physiolo	1.43997933
31	MP0003806_abnormal_nucleotide_metabolis	1.39886302
32	MP0008057_abnormal_DNA_replication	1.38756268
33	MP0002653_abnormal_ependyma_morphology	1.37974733
34	MP0008007_abnormal_cellular_replicative	1.37438929
35	MP0002398_abnormal_bone_marrow	1.37082466
36	MP0005410_abnormal_fertilization	1.35168545
37	MP0005084_abnormal_gallbladder_morpholo	1.31743180
38	MP0008872_abnormal_physiological_respon	1.31638335
39	MP0003195_calcinosis	1.31104422
40	MP0002148_abnormal_hypersensitivity_rea	1.29917629
41	MP0010307_abnormal_tumor_latency	1.29486907
42	MP0006036_abnormal_mitochondrial_physio	1.28966026
43	MP0003077_abnormal_cell_cycle	1.28554882
44	MP0002006_tumorigenesis	1.27476132
45	MP0008875_abnormal_xenobiotic_pharmacok	1.27253657
46	MP0003763_abnormal_thymus_physiology	1.26460237
47	MP0000689_abnormal_spleen_morphology	1.26358292
48	MP0003786_premature_aging	1.25988049
49	MP0010234_abnormal_vibrissa_follicle	1.25891655
50	MP0005167_abnormal_blood-brain_barrier	1.24644363
51	MP0004084_abnormal_cardiac_muscle	1.22986669
52	MP0002019_abnormal_tumor_incidence	1.21757726
53	MP0001800_abnormal_humoral_immune	1.18018585
54	MP0003828_pulmonary_edema	1.16989488
55	MP0002722_abnormal_immune_system	1.16165944
56	MP0005000_abnormal_immune_tolerance	1.12893049
57	MP0000372_irregular_coat_pigmentation	1.12597514
58	MP0004947_skin_inflammation	1.10162283
59	MP0010368_abnormal_lymphatic_system	1.09170663
60	MP0002723_abnormal_immune_serum	1.06245707
61	MP0005646_abnormal_pituitary_gland	1.05718651
62	MP0002452_abnormal_antigen_presenting	1.03184734
63	MP0004957_abnormal_blastocyst_morpholog	1.03172294
64	MP0002876_abnormal_thyroid_physiology	1.02410599
65	MP0003718_maternal_effect	0.99570062
66	MP0002429_abnormal_blood_cell	0.99351297
67	MP0000703_abnormal_thymus_morphology	0.99227106
68	MP0002420_abnormal_adaptive_immunity	0.97890507
69	MP0001819_abnormal_immune_cell	0.96463009
70	MP0003252_abnormal_bile_duct	0.95967822
71	MP0002419_abnormal_innate_immunity	0.95620004
72	MP0006035_abnormal_mitochondrial_morpho	0.93833609
73	MP0000716_abnormal_immune_system	0.92638022
74	MP0000685_abnormal_immune_system	0.92274022
75	MP0002138_abnormal_hepatobiliary_system	0.91723845
76	MP0004484_altered_response_of	0.90463215
77	MP0003172_abnormal_lysosome_physiology	0.89880920
78	MP0009763_increased_sensitivity_to	0.89652502
79	MP0000371_diluted_coat_color	0.88125909
80	MP0001879_abnormal_lymphatic_vessel	0.87156569
81	MP0000230_abnormal_systemic_arterial	0.86427738
82	MP0008995_early_reproductive_senescence	0.85702542
83	MP0001929_abnormal_gametogenesis	0.85305721
84	MP0001485_abnormal_pinna_reflex	0.83970811
85	MP0008961_abnormal_basal_metabolism	0.83755062
86	MP0002638_abnormal_pupillary_reflex	0.82053664
87	MP0002095_abnormal_skin_pigmentation	0.81416581
88	MP0005671_abnormal_response_to	0.81149859
89	MP0003436_decreased_susceptibility_to	0.81106310
90	MP0005025_abnormal_response_to	0.80158077
91	MP0002160_abnormal_reproductive_system	0.78760639
92	MP0001502_abnormal_circadian_rhythm	0.77890295
93	MP0001881_abnormal_mammary_gland	0.76231677
94	MP0010329_abnormal_lipoprotein_level	0.75516762
95	MP0005647_abnormal_sex_gland	0.75223242
96	MP0003186_abnormal_redox_activity	0.74823686
97	MP0000358_abnormal_cell_content/	0.73385803
98	MP0001845_abnormal_inflammatory_respons	0.72912077
99	MP0003950_abnormal_plasma_membrane	0.72607785
100	MP0000313_abnormal_cell_death	0.70825859

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Petechiae (HP:0000967)	6.18595317
2	Prolonged bleeding time (HP:0003010)	6.13974564
3	Increased mean platelet volume (HP:0011877)	5.16425483
4	Menorrhagia (HP:0000132)	4.96525338
5	Abnormal platelet volume (HP:0011876)	4.86549079
6	Purpura (HP:0000979)	3.93246305
7	Epistaxis (HP:0000421)	3.83630212
8	Panhypogammaglobulinemia (HP:0003139)	3.43306333
9	Autoimmune hemolytic anemia (HP:0001890)	3.22141714
10	Impaired platelet aggregation (HP:0003540)	3.20781064
11	Abnormal platelet function (HP:0011869)	3.20781064
12	B lymphocytopenia (HP:0010976)	3.09159703
13	Abnormality of B cell number (HP:0010975)	3.05251990
14	Acanthocytosis (HP:0001927)	3.03517467
15	Absent thumb (HP:0009777)	3.02826506
16	Poikilocytosis (HP:0004447)	2.99290580
17	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.98457134
18	Generalized hypopigmentation of hair (HP:0011358)	2.97223740
19	Gingival bleeding (HP:0000225)	2.91448539
20	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.86995664
21	Eosinophilia (HP:0001880)	2.83172331
22	Granulocytopenia (HP:0001913)	2.80633033
23	Abnormality of lateral ventricle (HP:0030047)	2.75097306
24	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.66171345
25	Chromsome breakage (HP:0040012)	2.65196436
26	Paralysis (HP:0003470)	2.57672985
27	Clubbing of toes (HP:0100760)	2.56522973
28	Abnormality of chromosome stability (HP:0003220)	2.55313040
29	Acute lymphatic leukemia (HP:0006721)	2.54777523
30	Myelodysplasia (HP:0002863)	2.52889628
31	Abnormality of the preputium (HP:0100587)	2.51828316
32	Generalized aminoaciduria (HP:0002909)	2.51100806
33	Albinism (HP:0001022)	2.50447638
34	Tinnitus (HP:0000360)	2.44734513
35	Ectopic kidney (HP:0000086)	2.43790001
36	Carpal bone hypoplasia (HP:0001498)	2.42296421
37	Duplicated collecting system (HP:0000081)	2.42051029
38	Aplastic anemia (HP:0001915)	2.41865014
39	Congenital stationary night blindness (HP:0007642)	2.41675636
40	Abnormality of iron homeostasis (HP:0011031)	2.40778822
41	Meckel diverticulum (HP:0002245)	2.38801195
42	Nausea (HP:0002018)	2.36387170
43	Abnormality of the ileum (HP:0001549)	2.33789113
44	Dyschromatopsia (HP:0007641)	2.33139034
45	Thyroiditis (HP:0100646)	2.30153569
46	Recurrent fungal infections (HP:0002841)	2.26110594
47	Abnormality of transition element cation homeostasis (HP:0011030)	2.25841911
48	Renal Fanconi syndrome (HP:0001994)	2.21988447
49	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.20579990
50	Hypoplasia of the fovea (HP:0007750)	2.20579990
51	Abnormality of the renal collecting system (HP:0004742)	2.18912252
52	Chronic otitis media (HP:0000389)	2.16372395
53	Recurrent viral infections (HP:0004429)	2.14286265
54	Severe combined immunodeficiency (HP:0004430)	2.09747599
55	Decreased central vision (HP:0007663)	2.09653143
56	Progressive muscle weakness (HP:0003323)	2.08965522
57	Hyperlipoproteinemia (HP:0010980)	2.07549899
58	Small intestinal stenosis (HP:0012848)	2.07389786
59	Duodenal stenosis (HP:0100867)	2.07389786
60	Bone marrow hypocellularity (HP:0005528)	2.05233343
61	Ileus (HP:0002595)	2.05138903
62	Squamous cell carcinoma (HP:0002860)	2.05081404
63	Fair hair (HP:0002286)	2.04773985
64	Autoimmune thrombocytopenia (HP:0001973)	2.04343177
65	Acute myeloid leukemia (HP:0004808)	2.02637999
66	Leukocytosis (HP:0001974)	2.02555731
67	Hyperthyroidism (HP:0000836)	2.02348571
68	Short thumb (HP:0009778)	2.00002569
69	Abnormality of pyrimidine metabolism (HP:0004353)	1.98369673
70	Renal cortical cysts (HP:0000803)	1.97876717
71	Abnormal drinking behavior (HP:0030082)	1.97540179
72	Polydipsia (HP:0001959)	1.97540179
73	Abnormality of the fovea (HP:0000493)	1.95823033
74	Hypophosphatemic rickets (HP:0004912)	1.95768127
75	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.95723458
76	Prominent nose (HP:0000448)	1.95260994
77	Elevated erythrocyte sedimentation rate (HP:0003565)	1.93726904
78	Hypergonadotropic hypogonadism (HP:0000815)	1.91010253
79	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.90949147
80	Abnormality of the renal cortex (HP:0011035)	1.89264302
81	Attenuation of retinal blood vessels (HP:0007843)	1.87809949
82	Abnormality of eosinophils (HP:0001879)	1.86560554
83	Abnormality of the carotid arteries (HP:0005344)	1.84849880
84	Combined immunodeficiency (HP:0005387)	1.82941316
85	Lip pit (HP:0100267)	1.81707063
86	Ocular albinism (HP:0001107)	1.80278187
87	Generalized hypopigmentation (HP:0007513)	1.80095145
88	Encephalitis (HP:0002383)	1.79354354
89	Acute hepatic failure (HP:0006554)	1.79119214
90	White forelock (HP:0002211)	1.79091703
91	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.76987017
92	Bruising susceptibility (HP:0000978)	1.76870476
93	Cutaneous melanoma (HP:0012056)	1.76114320
94	Pancytopenia (HP:0001876)	1.74799323
95	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.71287026
96	Abnormal rod and cone electroretinograms (HP:0008323)	1.70734964
97	Abnormality of dental color (HP:0011073)	1.69644681
98	Hypoplasia of the thymus (HP:0000778)	1.64372868
99	Reduced antithrombin III activity (HP:0001976)	1.63561813
100	Recurrent cutaneous fungal infections (HP:0011370)	1.63272717

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	6.08238066
2	TLK1	6.00436262
3	TAOK3	4.36181698
4	MST4	3.13715226
5	RIPK4	2.78971321
6	FRK	2.20670224
7	MARK3	2.15240578
8	NUAK1	2.08620211
9	VRK1	2.07045514
10	CCNB1	2.05716287
11	AKT3	1.93965414
12	CAMK1D	1.86449588
13	TEC	1.83591090
14	BRSK2	1.72256140
15	MAP4K2	1.61118654
16	PDK2	1.59109407
17	BTK	1.56931780
18	MAP3K14	1.49506067
19	GRK1	1.48839892
20	FLT3	1.42387819
21	BMPR1B	1.37416470
22	CAMKK2	1.36936940
23	IKBKB	1.34974497
24	PIK3CG	1.17506295
25	RPS6KA5	1.16604110
26	MAP2K3	1.16216128
27	WEE1	1.14001536
28	SYK	1.09939257
29	CAMK1G	1.09614725
30	PBK	1.09595186
31	STK16	1.05090695
32	DYRK3	1.04364183
33	BUB1	1.04010503
34	BMX	1.00330898
35	ZAP70	1.00222209
36	ACVR1B	0.96734098
37	GRK6	0.96272771
38	CDK12	0.96233260
39	PRKCQ	0.94065423
40	MAPK11	0.91788133
41	STK4	0.89886826
42	ADRBK2	0.89133353
43	ATR	0.83842482
44	BLK	0.82010003
45	MYLK	0.79832467
46	PIM1	0.76557875
47	EIF2AK3	0.76328413
48	PTK2B	0.76147156
49	BMPR2	0.75781107
50	MAP3K5	0.75776754
51	MUSK	0.75485542
52	MAP3K3	0.68246330
53	TTK	0.67033873
54	STK3	0.63599758
55	JAK2	0.63307581
56	NEK2	0.61756765
57	PAK1	0.61581820
58	EIF2AK1	0.61268750
59	NLK	0.60999358
60	PKN1	0.60583132
61	AURKA	0.59657543
62	STK24	0.59547508
63	CDC7	0.56497629
64	CHEK2	0.55235531
65	TNK2	0.54632922
66	MAP2K1	0.53026686
67	KIT	0.52074602
68	MAPKAPK3	0.51364332
69	HCK	0.48322553
70	MAPK15	0.47210842
71	MELK	0.45100973
72	RAF1	0.43240561
73	LYN	0.41573592
74	JAK3	0.40178469
75	CSNK1G3	0.39709434
76	PHKG2	0.38530383
77	PHKG1	0.38530383
78	PINK1	0.37368133
79	DAPK3	0.36834433
80	IKBKE	0.36743519
81	ADRBK1	0.36525886
82	LATS1	0.36363199
83	PRKAA1	0.36336103
84	MAPK12	0.36304380
85	ITK	0.33723260
86	PRKCI	0.33534441
87	GRK5	0.33425117
88	CSNK1G1	0.33159674
89	ATM	0.31819703
90	ILK	0.31351711
91	MAP2K2	0.30806041
92	MAP3K1	0.30509204
93	PLK1	0.30017428
94	CSNK1A1L	0.27783675
95	HIPK2	0.27674530
96	PIM2	0.26748201
97	MAP4K1	0.26544643
98	PLK3	0.26326150
99	AURKB	0.26222604
100	IRAK1	0.25622113

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus_Homo sapiens_hsa05322	5.92841090
2	Alcoholism_Homo sapiens_hsa05034	4.08351399
3	Fanconi anemia pathway_Homo sapiens_hsa03460	2.95995080
4	Platelet activation_Homo sapiens_hsa04611	2.34733178
5	Olfactory transduction_Homo sapiens_hsa04740	2.28779614
6	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.27558103
7	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.11965344
8	RNA polymerase_Homo sapiens_hsa03020	2.10064370
9	Viral carcinogenesis_Homo sapiens_hsa05203	2.07189165
10	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.96157556
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.91379014
12	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.81959412
13	Homologous recombination_Homo sapiens_hsa03440	1.78369042
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.75933876
15	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.67747313
16	Chemical carcinogenesis_Homo sapiens_hsa05204	1.67417014
17	Primary immunodeficiency_Homo sapiens_hsa05340	1.63737993
18	Base excision repair_Homo sapiens_hsa03410	1.56119688
19	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.55538980
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.51580083
21	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.43444270
22	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.37870175
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.36612831
24	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.34203841
25	Mismatch repair_Homo sapiens_hsa03430	1.32107699
26	DNA replication_Homo sapiens_hsa03030	1.31576094
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.31264935
28	Caffeine metabolism_Homo sapiens_hsa00232	1.27415821
29	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.23977220
30	Glutathione metabolism_Homo sapiens_hsa00480	1.21681313
31	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.21257389
32	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.21231982
33	Basal transcription factors_Homo sapiens_hsa03022	1.15823780
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.15460429
35	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.14291996
36	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.11116218
37	Linoleic acid metabolism_Homo sapiens_hsa00591	1.09213654
38	Cell cycle_Homo sapiens_hsa04110	1.04777294
39	Retinol metabolism_Homo sapiens_hsa00830	1.04575512
40	Pyrimidine metabolism_Homo sapiens_hsa00240	1.03668131
41	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.00593323
42	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.98809010
43	p53 signaling pathway_Homo sapiens_hsa04115	0.96697161
44	Lysine degradation_Homo sapiens_hsa00310	0.96161775
45	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.94093031
46	Butanoate metabolism_Homo sapiens_hsa00650	0.92645295
47	Purine metabolism_Homo sapiens_hsa00230	0.91414429
48	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.86586564
49	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.84451697
50	One carbon pool by folate_Homo sapiens_hsa00670	0.83681366
51	Phototransduction_Homo sapiens_hsa04744	0.74181967
52	Acute myeloid leukemia_Homo sapiens_hsa05221	0.73255628
53	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.72034688
54	Measles_Homo sapiens_hsa05162	0.71313658
55	Herpes simplex infection_Homo sapiens_hsa05168	0.68294971
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.67545557
57	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.65605584
58	Tryptophan metabolism_Homo sapiens_hsa00380	0.63099201
59	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.63063356
60	Sphingolipid metabolism_Homo sapiens_hsa00600	0.62596279
61	Legionellosis_Homo sapiens_hsa05134	0.62066894
62	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.61214574
63	RNA degradation_Homo sapiens_hsa03018	0.59283668
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58067624
65	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.57923928
66	Non-small cell lung cancer_Homo sapiens_hsa05223	0.54902333
67	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.54163480
68	Leishmaniasis_Homo sapiens_hsa05140	0.53891660
69	Apoptosis_Homo sapiens_hsa04210	0.53555643
70	Non-homologous end-joining_Homo sapiens_hsa03450	0.51326861
71	Asthma_Homo sapiens_hsa05310	0.50688018
72	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.49930686
73	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.49527748
74	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.48322933
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.46999078
76	Oocyte meiosis_Homo sapiens_hsa04114	0.46176576
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45000058
78	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.44750261
79	TNF signaling pathway_Homo sapiens_hsa04668	0.43697919
80	Tuberculosis_Homo sapiens_hsa05152	0.43393402
81	Osteoclast differentiation_Homo sapiens_hsa04380	0.42797872
82	FoxO signaling pathway_Homo sapiens_hsa04068	0.42616663
83	Allograft rejection_Homo sapiens_hsa05330	0.42293244
84	Tyrosine metabolism_Homo sapiens_hsa00350	0.42241890
85	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.41825963
86	Graft-versus-host disease_Homo sapiens_hsa05332	0.41495425
87	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40820000
88	Hepatitis B_Homo sapiens_hsa05161	0.40600800
89	Peroxisome_Homo sapiens_hsa04146	0.39377107
90	Prostate cancer_Homo sapiens_hsa05215	0.39028900
91	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.37610007
92	Complement and coagulation cascades_Homo sapiens_hsa04610	0.37431787
93	Fatty acid elongation_Homo sapiens_hsa00062	0.34865927
94	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.29870990
95	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.27417758
96	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.27195568
97	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.27040821
98	Small cell lung cancer_Homo sapiens_hsa05222	0.26047211
99	Metabolic pathways_Homo sapiens_hsa01100	0.24758066
100	Chemokine signaling pathway_Homo sapiens_hsa04062	0.24605509

HIST1H1PS1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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