HIST1H1T

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis (GO:0007140)9.96066133
2synaptonemal complex organization (GO:0070193)9.85332532
3acrosome assembly (GO:0001675)9.80722004
4* sperm motility (GO:0030317)9.78026717
5synaptonemal complex assembly (GO:0007130)9.21175457
6* sperm-egg recognition (GO:0035036)9.14830534
7spermatid development (GO:0007286)9.07420015
8* binding of sperm to zona pellucida (GO:0007339)8.62785362
9DNA methylation involved in gamete generation (GO:0043046)8.59599035
10cell wall macromolecule catabolic process (GO:0016998)8.25185882
11cell wall macromolecule metabolic process (GO:0044036)8.25185882
12epithelial cilium movement (GO:0003351)8.21654437
13multicellular organism reproduction (GO:0032504)8.18274908
14* cell-cell recognition (GO:0009988)8.15238484
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.87372192
16protein neddylation (GO:0045116)7.86572222
17plasma membrane fusion (GO:0045026)7.73566621
18regulation of cilium movement (GO:0003352)7.20949496
19cilium movement (GO:0003341)7.06387038
20negative regulation of inclusion body assembly (GO:0090084)6.99219531
21thrombin receptor signaling pathway (GO:0070493)6.94117378
22male meiosis I (GO:0007141)6.92098289
23reproduction (GO:0000003)6.75280922
24chromosome organization involved in meiosis (GO:0070192)6.54854702
25neutrophil activation involved in immune response (GO:0002283)6.24133702
26meiotic nuclear division (GO:0007126)6.21061522
27* spermatogenesis (GO:0007283)5.95662700
28* male gamete generation (GO:0048232)5.93485042
29triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.82167186
30single fertilization (GO:0007338)5.70695378
31organic cation transport (GO:0015695)5.69958378
32meiosis I (GO:0007127)5.65792079
33polyamine biosynthetic process (GO:0006596)5.63146168
34fertilization (GO:0009566)5.57692469
35seminiferous tubule development (GO:0072520)5.57537797
36regulation of inclusion body assembly (GO:0090083)5.48045000
37* gamete generation (GO:0007276)5.44488009
38meiotic cell cycle (GO:0051321)5.44318228
39germ cell development (GO:0007281)5.41044625
40cellular process involved in reproduction in multicellular organism (GO:0022412)5.34770341
41regulation of platelet aggregation (GO:0090330)5.25072320
42gene silencing by RNA (GO:0031047)5.10538668
43protein localization to cilium (GO:0061512)5.09169972
44adenosine receptor signaling pathway (GO:0001973)5.08216743
45negative regulation of homotypic cell-cell adhesion (GO:0034111)5.02042662
46regulation of platelet activation (GO:0010543)5.00213289
47negative regulation of norepinephrine secretion (GO:0010700)5.00023847
48microtubule depolymerization (GO:0007019)4.97598229
49blood coagulation, intrinsic pathway (GO:0007597)4.92877095
50sperm capacitation (GO:0048240)4.86054332
51platelet aggregation (GO:0070527)4.80782682
52ventricular system development (GO:0021591)4.77114360
53microtubule severing (GO:0051013)4.73947151
54negative regulation of platelet activation (GO:0010544)4.67895949
55DNA synthesis involved in DNA repair (GO:0000731)4.62319079
56left/right pattern formation (GO:0060972)4.57951300
57nucleosome disassembly (GO:0006337)4.57812061
58protein-DNA complex disassembly (GO:0032986)4.57812061
59negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.53597250
60leukocyte migration involved in inflammatory response (GO:0002523)4.45981579
61relaxation of smooth muscle (GO:0044557)4.45635297
62regulation of Golgi to plasma membrane protein transport (GO:0042996)4.45087259
63calcium ion-dependent exocytosis (GO:0017156)4.43507807
64negative regulation of thymocyte apoptotic process (GO:0070244)4.35730270
65positive regulation of endothelial cell differentiation (GO:0045603)4.35719070
66regulation of phosphoprotein phosphatase activity (GO:0043666)4.31659305
67regulation of microtubule-based movement (GO:0060632)4.27319670
68* multicellular organismal reproductive process (GO:0048609)4.21975937
69genitalia morphogenesis (GO:0035112)4.20947505
70DNA packaging (GO:0006323)4.17418715
71regulation of integrin-mediated signaling pathway (GO:2001044)4.13413648
72negative regulation of heart rate (GO:0010459)4.11589827
73carnitine transmembrane transport (GO:1902603)4.10208134
74negative regulation of response to food (GO:0032096)4.07653776
75negative regulation of appetite (GO:0032099)4.07653776
76chromosome condensation (GO:0030261)4.04057894
77carnitine transport (GO:0015879)4.03149288
78amino-acid betaine transport (GO:0015838)4.03149288
79meiotic cell cycle process (GO:1903046)3.96766766
80regulation of meiosis I (GO:0060631)3.96600087
81negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.96296361
82synapsis (GO:0007129)3.91273053
83innate immune response in mucosa (GO:0002227)3.89683692
84cellular biogenic amine biosynthetic process (GO:0042401)3.88133375
85* cell recognition (GO:0008037)3.86487572
86low-density lipoprotein particle remodeling (GO:0034374)3.84019458
87lipoxygenase pathway (GO:0019372)3.83223679
88regulation of spindle checkpoint (GO:0090231)3.82655710
89G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.81262037
90poly(A)+ mRNA export from nucleus (GO:0016973)3.79660284
91protein polyglutamylation (GO:0018095)3.79394188
92interferon-gamma secretion (GO:0072643)3.78754173
93negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.78261798
94negative regulation of T-helper cell differentiation (GO:0045623)3.78261798
95polyamine metabolic process (GO:0006595)3.78186994
96chaperone-mediated protein complex assembly (GO:0051131)3.73937868
97intraciliary transport (GO:0042073)3.72263650
98negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.70327786
99nuclear pore complex assembly (GO:0051292)3.68486440
100positive regulation of Rho protein signal transduction (GO:0035025)3.66944666
101positive regulation of protein homodimerization activity (GO:0090073)3.65464622
102amine biosynthetic process (GO:0009309)3.63890690
103gene silencing (GO:0016458)3.52335913
104regulation of oxidative phosphorylation (GO:0002082)3.51294351
105purinergic nucleotide receptor signaling pathway (GO:0035590)3.50381894
106translesion synthesis (GO:0019985)3.50281611
107neutrophil activation (GO:0042119)3.46919065
108mitotic sister chromatid cohesion (GO:0007064)3.46913149
109* multicellular organismal development (GO:0007275)3.44364523
110positive regulation of cAMP-mediated signaling (GO:0043950)3.41384692
111regulation of RIG-I signaling pathway (GO:0039535)3.39594504
112histone exchange (GO:0043486)3.36250705
113negative regulation of organelle assembly (GO:1902116)3.34930672
114negative regulation of neural precursor cell proliferation (GO:2000178)3.34128901
115DNA alkylation (GO:0006305)3.34059510
116DNA methylation (GO:0006306)3.34059510
117regulation of integrin activation (GO:0033623)3.32920647
118homotypic cell-cell adhesion (GO:0034109)3.31661795
119platelet degranulation (GO:0002576)3.30338466
120mucosal immune response (GO:0002385)3.26040077
121negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.25468794
122extracellular fibril organization (GO:0043206)3.24904550
123negative regulation of heart contraction (GO:0045822)3.23612151
124angiogenesis involved in wound healing (GO:0060055)3.22206347
125protein refolding (GO:0042026)3.20787286
126negative regulation of muscle contraction (GO:0045932)3.19429971
127regulation of norepinephrine secretion (GO:0014061)3.17597113
128beta-amyloid metabolic process (GO:0050435)3.15905617
129positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.15873591
130negative regulation of stress fiber assembly (GO:0051497)3.15131050
131axoneme assembly (GO:0035082)3.14684825
132monoubiquitinated protein deubiquitination (GO:0035520)3.14475829
133platelet activation (GO:0030168)3.13659565
134regulation of homotypic cell-cell adhesion (GO:0034110)3.13536683
135regulation of female receptivity (GO:0045924)3.12328204
136high-density lipoprotein particle remodeling (GO:0034375)3.12298917
137fibril organization (GO:0097435)3.10430093
138polyol catabolic process (GO:0046174)3.10369619
139platelet formation (GO:0030220)3.09710983
140regulation of megakaryocyte differentiation (GO:0045652)3.09662624
141peptidyl-glutamic acid modification (GO:0018200)3.08864924
142regulation of histone H3-K9 methylation (GO:0051570)3.08254567
143negative regulation of protein localization to cell surface (GO:2000009)3.07113483
144negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.06425609
145protein polymerization (GO:0051258)3.05548913
146microtubule-based movement (GO:0007018)3.03385387
147granulocyte activation (GO:0036230)3.02979578
148megakaryocyte development (GO:0035855)3.02863712
149regulation of chromatin binding (GO:0035561)3.01926579
150RNA localization (GO:0006403)3.01830561
151termination of G-protein coupled receptor signaling pathway (GO:0038032)3.01413091
152nucleus organization (GO:0006997)3.00963451
153positive regulation of receptor recycling (GO:0001921)3.00382904
154positive regulation of mast cell activation (GO:0033005)2.98196020
155positive regulation of macrophage differentiation (GO:0045651)2.97673228
156dopamine transport (GO:0015872)2.97365336
157antibacterial humoral response (GO:0019731)2.97166764
158regulation of memory T cell differentiation (GO:0043380)2.96642171
159membrane invagination (GO:0010324)2.95275499
160nuclear pore organization (GO:0006999)2.94579660
161regulation of lipoprotein metabolic process (GO:0050746)2.92922024
162positive regulation of systemic arterial blood pressure (GO:0003084)2.92511948
163positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.92428998
164regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.92428998
165cilium organization (GO:0044782)2.92300656
166regulation of endothelial cell differentiation (GO:0045601)2.91605852
167mitochondrial calcium ion transport (GO:0006851)2.91467898
168cilium morphogenesis (GO:0060271)2.91311974
169spermatid nucleus differentiation (GO:0007289)2.89907098
170alditol metabolic process (GO:0019400)2.89665700
171regulation of protein polyubiquitination (GO:1902914)2.88491527
172pore complex assembly (GO:0046931)2.88412707
173quaternary ammonium group transport (GO:0015697)2.79455261
174regulation of centriole replication (GO:0046599)2.79208315
175rRNA catabolic process (GO:0016075)2.77500956
176cilium assembly (GO:0042384)2.73823084
177piRNA metabolic process (GO:0034587)12.8441370
178cilium or flagellum-dependent cell motility (GO:0001539)12.3654398
179axonemal dynein complex assembly (GO:0070286)11.1115176
180acrosome reaction (GO:0007340)10.3336009
181fusion of sperm to egg plasma membrane (GO:0007342)10.2209209
182motile cilium assembly (GO:0044458)10.1928843

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.31339047
2EZH2_22144423_ChIP-Seq_EOC_Human6.04794129
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.07951716
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.84251124
5SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.63066168
6SCL_19346495_ChIP-Seq_HPC-7_Human3.77840845
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.73695066
8IGF1R_20145208_ChIP-Seq_DFB_Human3.54858618
9LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.83755218
10GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.77518501
11GATA1_22025678_ChIP-Seq_K562_Human2.71295807
12GATA1_19941826_ChIP-Seq_K562_Human2.59943137
13CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.58793583
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.52773257
15GATA2_19941826_ChIP-Seq_K562_Human2.45199575
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.25366805
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.23740065
18GBX2_23144817_ChIP-Seq_PC3_Human2.22540832
19ESR1_20079471_ChIP-ChIP_T-47D_Human2.19315696
20ELK4_26923725_Chip-Seq_MESODERM_Mouse2.17890768
21ZNF274_21170338_ChIP-Seq_K562_Hela2.17293115
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.09079324
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse12.9930235
24TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.94947635
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.93253975
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.93092040
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90357510
28EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.88983993
29LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.84905740
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81370939
31HTT_18923047_ChIP-ChIP_STHdh_Human1.77812279
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.76635932
33GATA1_22383799_ChIP-Seq_G1ME_Mouse1.70723799
34FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69292960
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67860360
36SPI1_23127762_ChIP-Seq_K562_Human1.66145596
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65513513
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59434450
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.58476556
40HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.57187898
41SALL4_22934838_ChIP-ChIP_CD34+_Human1.55962353
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.51957183
43* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49546549
44TAF15_26573619_Chip-Seq_HEK293_Human1.48180320
45WDR5_24793694_ChIP-Seq_LNCAP_Human1.46911162
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.45648408
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42638009
48GATA3_21867929_ChIP-Seq_CD8_Mouse1.42603451
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42164420
50STAT1_17558387_ChIP-Seq_HELA_Human1.42023283
51E2F7_22180533_ChIP-Seq_HELA_Human1.41846265
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40795471
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40215565
54EWS_26573619_Chip-Seq_HEK293_Human1.39624557
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.38939594
56PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38857959
57IRF1_19129219_ChIP-ChIP_H3396_Human1.38826036
58FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33324989
59OCT1_27270436_Chip-Seq_PROSTATE_Human1.30858172
60TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.29876714
61SOX2_22085726_ChIP-Seq_NPCs_Mouse1.29139393
62ER_23166858_ChIP-Seq_MCF-7_Human1.29125043
63KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28221051
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.26409964
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26276104
66VDR_22108803_ChIP-Seq_LS180_Human1.25786958
67RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22152326
68GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.22082547
69SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21070014
70VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21003951
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20216918
72RNF2_27304074_Chip-Seq_NSC_Mouse1.19978684
73AR_25329375_ChIP-Seq_VCAP_Human1.19271004
74* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17957803
75SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.17389256
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16207287
77TAL1_26923725_Chip-Seq_HPCs_Mouse1.15594866
78REST_21632747_ChIP-Seq_MESCs_Mouse1.14621148
79RUNX1_26923725_Chip-Seq_HPCs_Mouse1.14286561
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.12909374
81GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12660270
82CBP_20019798_ChIP-Seq_JUKART_Human1.11931513
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11931513
84LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.11878129
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.11819161
86* SMAD4_21799915_ChIP-Seq_A2780_Human1.11666331
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11238468
88* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.09873567
89TDRD3_21172665_ChIP-Seq_MCF-7_Human1.08974456
90FUS_26573619_Chip-Seq_HEK293_Human1.08868244
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08352526
92RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08330604
93P53_21459846_ChIP-Seq_SAOS-2_Human1.07335080
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06510389
95PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06260741
96SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06239049
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05812901
98* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05387015
99MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02303013
100CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02173760
101TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.02110513
102* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.01229492
103KDM2B_26808549_Chip-Seq_REH_Human1.00749669
104MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00530399
105NANOG_19829295_ChIP-Seq_ESCs_Human1.00173303
106SOX2_19829295_ChIP-Seq_ESCs_Human1.00173303
107PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00136072
108YY1_22570637_ChIP-Seq_MALME-3M_Human0.99743934
109NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99082346
110TBL1_22424771_ChIP-Seq_293T_Human0.98511730
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97527333
112PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96994776
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96985480
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96689924
115NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96544801
116RARA_24833708_ChIP-Seq_LIVER_Mouse0.96399927
117BCAT_22108803_ChIP-Seq_LS180_Human0.96001216
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95838710
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95838710
120TET1_21451524_ChIP-Seq_MESCs_Mouse0.95645940
121PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95559589
122RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93899464
123GF1_26923725_Chip-Seq_HPCs_Mouse0.92562686
124ESET_19884257_ChIP-Seq_ESCs_Mouse0.92528881
125ELF1_20517297_ChIP-Seq_JURKAT_Human0.91944534
126KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.91758503
127RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91432361
128ERG_20517297_ChIP-Seq_VCAP_Human0.91360420
129FLI1_21867929_ChIP-Seq_TH2_Mouse0.91110849
130LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90746237
131NCOR1_26117541_ChIP-Seq_K562_Human0.90614087
132* MYC_27129775_Chip-Seq_CORNEA_Mouse0.89517260
133EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89476940
134RUNX_20019798_ChIP-Seq_JUKART_Human0.88452219
135CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88087034
136ARNT_22903824_ChIP-Seq_MCF-7_Human0.87488930
137NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87462729
138SOX2_21211035_ChIP-Seq_LN229_Human0.86851913
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86504221
140SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85865213
141SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85340402
142TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85185149
143SPI1_26923725_Chip-Seq_HPCs_Mouse0.84997844
144PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84846061
145HNFA_21074721_ChIP-Seq_CACO-2_Human0.84598301
146GATA3_27048872_Chip-Seq_THYMUS_Human0.84545682
147PHF8_20622854_ChIP-Seq_HELA_Human0.84321232
148SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84186299
149POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84044397
150PRDM14_20953172_ChIP-Seq_ESCs_Human0.83870891
151E2F4_17652178_ChIP-ChIP_JURKAT_Human0.83539201
152GATA3_21867929_ChIP-Seq_TH1_Mouse0.83505194
153CRX_20693478_ChIP-Seq_RETINA_Mouse0.83387730
154LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83147035
155NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83140996
156NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83140996
157KLF4_19829295_ChIP-Seq_ESCs_Human0.82881614
158FLI1_21867929_ChIP-Seq_CD8_Mouse0.82328904
159GATA3_21878914_ChIP-Seq_MCF-7_Human0.82277949
160CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81989770
161GATA1_19941827_ChIP-Seq_MEL86_Mouse0.81977158
162CTCF_20526341_ChIP-Seq_ESCs_Human0.81131215
163PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80961855
164SPI1_20517297_ChIP-Seq_HL60_Human0.79579814
165PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79512351
166ETS1_22383799_ChIP-Seq_G1ME_Mouse0.79198040
167OCT4_19829295_ChIP-Seq_ESCs_Human0.78658142
168AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78505711
169SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78450695
170FOXM1_26456572_ChIP-Seq_MCF-7_Human0.78156669
171PHF8_20622853_ChIP-Seq_HELA_Human0.77587159
172NFYB_21822215_ChIP-Seq_K562_Human0.77530791
173CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.77017427
174OCT4_21477851_ChIP-Seq_ESCs_Mouse0.76069618
175TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.74688607
176CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.74533029
177CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.74507462
178OCT4_18555785_Chip-Seq_ESCs_Mouse0.73510829
179BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.72928976
180SOX11_22085726_ChIP-Seq_ESNs_Mouse0.71780301
181BCOR_27268052_Chip-Seq_Bcells_Human0.71362739
182RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71126694
183TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71030082

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology8.69553675
2MP0008004_abnormal_stomach_pH7.42497650
3MP0008877_abnormal_DNA_methylation6.14377549
4* MP0003698_abnormal_male_reproductive5.79737590
5MP0001929_abnormal_gametogenesis5.67553873
6MP0002210_abnormal_sex_determination4.03015873
7MP0001145_abnormal_male_reproductive3.43493126
8MP0000465_gastrointestinal_hemorrhage3.15412339
9* MP0002161_abnormal_fertility/fecundity3.12963329
10MP0000653_abnormal_sex_gland2.94834172
11MP0008057_abnormal_DNA_replication2.90046683
12MP0002653_abnormal_ependyma_morphology2.69686187
13MP0003724_increased_susceptibility_to2.56637555
14MP0003646_muscle_fatigue2.37132387
15MP0000343_altered_response_to2.27128604
16MP0002160_abnormal_reproductive_system2.27030509
17MP0002132_abnormal_respiratory_system2.20082054
18MP0000230_abnormal_systemic_arterial2.19512243
19MP0009697_abnormal_copulation2.14770485
20MP0001879_abnormal_lymphatic_vessel2.13941427
21MP0002736_abnormal_nociception_after2.03398788
22* MP0005410_abnormal_fertilization14.3089420
23MP0005058_abnormal_lysosome_morphology1.95723176
24MP0003718_maternal_effect1.88990631
25MP0004084_abnormal_cardiac_muscle1.84347165
26MP0005646_abnormal_pituitary_gland1.77211130
27MP0005670_abnormal_white_adipose1.76967657
28MP0001664_abnormal_digestion1.75100128
29MP0010094_abnormal_chromosome_stability1.73178981
30MP0003566_abnormal_cell_adhesion1.64413229
31MP0003638_abnormal_response/metabolism_1.63964487
32MP0001851_eye_inflammation1.62385761
33MP0004233_abnormal_muscle_weight1.62348645
34MP0003136_yellow_coat_color1.52837277
35MP0008775_abnormal_heart_ventricle1.51274903
36MP0005084_abnormal_gallbladder_morpholo1.47548681
37MP0005187_abnormal_penis_morphology1.44478439
38MP0005083_abnormal_biliary_tract1.43162367
39MP0010155_abnormal_intestine_physiology1.37530669
40MP0005623_abnormal_meninges_morphology1.34566492
41MP0001835_abnormal_antigen_presentation1.30664199
42MP0003011_delayed_dark_adaptation1.27400490
43MP0002398_abnormal_bone_marrow1.25938431
44MP0008007_abnormal_cellular_replicative1.20955439
45MP0003303_peritoneal_inflammation1.20195775
46MP0005167_abnormal_blood-brain_barrier1.17634663
47MP0008872_abnormal_physiological_respon1.16615022
48MP0003828_pulmonary_edema1.14933141
49MP0006276_abnormal_autonomic_nervous1.12754256
50MP0001968_abnormal_touch/_nociception1.10903003
51MP0004215_abnormal_myocardial_fiber1.10524734
52MP0003315_abnormal_perineum_morphology1.09704927
53MP0000249_abnormal_blood_vessel1.08837840
54MP0001984_abnormal_olfaction1.07361861
55MP0005389_reproductive_system_phenotype1.07051681
56MP0002282_abnormal_trachea_morphology1.05627362
57MP0008058_abnormal_DNA_repair1.05621135
58MP0004808_abnormal_hematopoietic_stem0.99041525
59MP0004272_abnormal_basement_membrane0.98797239
60MP0009046_muscle_twitch0.98246959
61MP0000490_abnormal_crypts_of0.97179991
62MP0003453_abnormal_keratinocyte_physiol0.94236213
63MP0003656_abnormal_erythrocyte_physiolo0.94103796
64MP0003879_abnormal_hair_cell0.92487312
65MP0003786_premature_aging0.91293506
66MP0003115_abnormal_respiratory_system0.88881000
67MP0004134_abnormal_chest_morphology0.85211941
68MP0004510_myositis0.85017614
69MP0002429_abnormal_blood_cell0.84834930
70MP0008260_abnormal_autophagy0.84298260
71MP0005620_abnormal_muscle_contractility0.84292696
72MP0003111_abnormal_nucleus_morphology0.83664174
73MP0008932_abnormal_embryonic_tissue0.83655514
74MP0009763_increased_sensitivity_to0.83303202
75MP0010368_abnormal_lymphatic_system0.83259906
76MP0004085_abnormal_heartbeat0.82072947
77MP0002722_abnormal_immune_system0.81693377
78MP0010307_abnormal_tumor_latency0.81077982
79MP0002733_abnormal_thermal_nociception0.80896526
80MP0000358_abnormal_cell_content/0.79195525
81MP0002972_abnormal_cardiac_muscle0.77452745
82MP0000703_abnormal_thymus_morphology0.77325782
83MP0005647_abnormal_sex_gland0.76494061
84MP0009278_abnormal_bone_marrow0.75418771
85MP0003806_abnormal_nucleotide_metabolis0.75053195
86MP0000015_abnormal_ear_pigmentation0.72980383
87MP0000689_abnormal_spleen_morphology0.70988413
88MP0010329_abnormal_lipoprotein_level0.70778525
89MP0009642_abnormal_blood_homeostasis0.70274128
90MP0010386_abnormal_urinary_bladder0.69155614
91MP0005397_hematopoietic_system_phenotyp0.67935747
92MP0001545_abnormal_hematopoietic_system0.67935747
93MP0008874_decreased_physiological_sensi0.63456289
94MP0002127_abnormal_cardiovascular_syste0.63171787
95MP0002148_abnormal_hypersensitivity_rea0.62929191
96MP0001730_embryonic_growth_arrest0.62687976
97MP0005423_abnormal_somatic_nervous0.61865755
98MP0006138_congestive_heart_failure0.61796932
99MP0002128_abnormal_blood_circulation0.61738439
100MP0001661_extended_life_span0.61496775
101MP0000716_abnormal_immune_system0.59702703
102MP0003329_amyloid_beta_deposits0.59517132
103MP0001544_abnormal_cardiovascular_syste0.59334556
104MP0005385_cardiovascular_system_phenoty0.59334556
105MP0001663_abnormal_digestive_system0.59226908
106MP0000383_abnormal_hair_follicle0.58187357
107MP0001765_abnormal_ion_homeostasis0.57911868
108MP0005671_abnormal_response_to0.57847113
109MP0003866_abnormal_defecation0.57584885
110MP0009765_abnormal_xenobiotic_induced0.57549830
111MP0003077_abnormal_cell_cycle0.57205757
112MP0001188_hyperpigmentation0.56643829
113MP0001986_abnormal_taste_sensitivity0.55903361
114MP0000569_abnormal_digit_pigmentation0.55832201
115MP0001919_abnormal_reproductive_system0.54778689
116MP0002269_muscular_atrophy0.54637688
117MP0002723_abnormal_immune_serum0.54536645
118MP0002234_abnormal_pharynx_morphology0.52429056
119MP0005666_abnormal_adipose_tissue0.51463503
120MP0001293_anophthalmia0.49246865
121MP0008961_abnormal_basal_metabolism0.46404763
122MP0003699_abnormal_female_reproductive0.46070620
123MP0006036_abnormal_mitochondrial_physio0.45935205
124MP0004811_abnormal_neuron_physiology0.45319358
125MP0003878_abnormal_ear_physiology0.44558037
126MP0005377_hearing/vestibular/ear_phenot0.44558037
127MP0006035_abnormal_mitochondrial_morpho0.44379700
128MP0001324_abnormal_eye_pigmentation0.44211900
129MP0003045_fibrosis0.44169209
130MP0003861_abnormal_nervous_system0.42970100
131MP0008995_early_reproductive_senescence0.42183026
132MP0004036_abnormal_muscle_relaxation0.41969487
133MP0000427_abnormal_hair_cycle0.41872334
134MP0002084_abnormal_developmental_patter0.41868020
135MP0003950_abnormal_plasma_membrane0.40693888
136MP0000313_abnormal_cell_death0.40232983
137MP0002971_abnormal_brown_adipose0.38806936
138MP0002152_abnormal_brain_morphology0.37267111
139MP0001697_abnormal_embryo_size0.34924153
140MP0005380_embryogenesis_phenotype0.34238608
141MP0001672_abnormal_embryogenesis/_devel0.34238608
142MP0001119_abnormal_female_reproductive0.33869462
143MP0005253_abnormal_eye_physiology0.32885236
144MP0002928_abnormal_bile_duct0.31576253
145MP0005391_vision/eye_phenotype0.31428785
146MP0000534_abnormal_ureter_morphology0.31341362
147MP0000604_amyloidosis0.30856614
148MP0003936_abnormal_reproductive_system0.30728972
149MP0000537_abnormal_urethra_morphology0.29824185
150MP0002139_abnormal_hepatobiliary_system0.29748353
151MP0003631_nervous_system_phenotype0.29165679
152MP0009115_abnormal_fat_cell0.27285416
153MP0005551_abnormal_eye_electrophysiolog0.27212250
154MP0005266_abnormal_metabolism0.26550667
155MP0005174_abnormal_tail_pigmentation0.26139756
156MP0003632_abnormal_nervous_system0.25450550
157MP0003633_abnormal_nervous_system0.25090442
158MP0002092_abnormal_eye_morphology0.24652091
159MP0002080_prenatal_lethality0.24527920
160MP0000647_abnormal_sebaceous_gland0.24260846
161MP0002697_abnormal_eye_size0.24038563
162MP0002085_abnormal_embryonic_tissue0.23898700
163MP0004133_heterotaxia0.23788594
164MP0003984_embryonic_growth_retardation0.23385731
165MP0001849_ear_inflammation0.23164569
166MP0005365_abnormal_bile_salt0.22978401
167MP0004130_abnormal_muscle_cell0.22966306
168MP0001727_abnormal_embryo_implantation0.22486130
169MP0002088_abnormal_embryonic_growth/wei0.21631106
170MP0003948_abnormal_gas_homeostasis0.21382878
171MP0004043_abnormal_pH_regulation0.21209067
172MP0003942_abnormal_urinary_system0.20554388
173MP0002295_abnormal_pulmonary_circulatio0.19428494

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)9.23685493
2Menorrhagia (HP:0000132)9.17274512
3Abnormal respiratory motile cilium physiology (HP:0012261)8.64524278
4Abnormal platelet volume (HP:0011876)8.62350795
5Abnormal respiratory motile cilium morphology (HP:0005938)7.97653326
6Abnormal respiratory epithelium morphology (HP:0012253)7.97653326
7Rhinitis (HP:0012384)7.78620999
8Petechiae (HP:0000967)7.78317932
9Chronic bronchitis (HP:0004469)7.64261453
10Purpura (HP:0000979)7.16297093
11Hyperlipoproteinemia (HP:0010980)6.78138460
12Epistaxis (HP:0000421)6.53618555
13Nasal polyposis (HP:0100582)6.45585785
14Infertility (HP:0000789)6.24004109
15Abnormal ciliary motility (HP:0012262)5.82149698
16Abnormality of the lower motor neuron (HP:0002366)5.47235380
17Abnormality of the nasal mucosa (HP:0000433)5.29117120
18Gingival bleeding (HP:0000225)5.15709444
19Acanthocytosis (HP:0001927)4.88580536
20Nephronophthisis (HP:0000090)4.68885029
21Impaired platelet aggregation (HP:0003540)4.61603610
22Abnormal platelet function (HP:0011869)4.61603610
23Bronchiectasis (HP:0002110)4.39856139
24Bronchitis (HP:0012387)4.34322188
25Poikilocytosis (HP:0004447)4.25446838
26Amyotrophic lateral sclerosis (HP:0007354)4.15931975
27Gonadotropin excess (HP:0000837)3.92965276
28Spontaneous hematomas (HP:0007420)3.80149347
29Papillary thyroid carcinoma (HP:0002895)3.56129446
30Abnormality of lateral ventricle (HP:0030047)3.53501396
31Paralysis (HP:0003470)3.50912562
32Abnormality of the renal medulla (HP:0100957)3.45849180
33Abnormal pupillary function (HP:0007686)3.38393765
34Upper motor neuron abnormality (HP:0002127)3.26178898
35Impaired proprioception (HP:0010831)3.24710561
36Fibular hypoplasia (HP:0003038)3.19292029
37Recurrent otitis media (HP:0000403)3.16875886
38Degeneration of anterior horn cells (HP:0002398)2.99679885
39Abnormality of the anterior horn cell (HP:0006802)2.99679885
40Abnormality of the common coagulation pathway (HP:0010990)2.99276576
41Abnormality of the heme biosynthetic pathway (HP:0010472)2.92417447
42Tubular atrophy (HP:0000092)2.91815071
43Ventricular fibrillation (HP:0001663)2.91560496
44Abnormal spermatogenesis (HP:0008669)2.88551869
45Abnormal auditory evoked potentials (HP:0006958)2.80927732
46Male infertility (HP:0003251)2.75424522
47Gonadal dysgenesis (HP:0000133)2.75018492
48Upper limb muscle weakness (HP:0003484)2.73293455
49Decreased central vision (HP:0007663)2.67166821
50Bruising susceptibility (HP:0000978)2.66727155
51Hypoplasia of the capital femoral epiphysis (HP:0003090)2.64249033
52Tubulointerstitial nephritis (HP:0001970)2.64129159
53Impulsivity (HP:0100710)2.63306346
54Nausea (HP:0002018)2.61000494
55Molar tooth sign on MRI (HP:0002419)2.59182184
56Abnormality of midbrain morphology (HP:0002418)2.59182184
57Spontaneous abortion (HP:0005268)2.53401902
58Tubulointerstitial abnormality (HP:0001969)2.52744577
59Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.50184888
60Medial flaring of the eyebrow (HP:0010747)2.48428384
61Resting tremor (HP:0002322)2.47912014
62Selective tooth agenesis (HP:0001592)2.46879418
63Azoospermia (HP:0000027)2.39607140
64Thyroid carcinoma (HP:0002890)2.38719359
6511 pairs of ribs (HP:0000878)2.34141360
66Inflammation of the large intestine (HP:0002037)2.32374198
67Central scotoma (HP:0000603)2.29378286
68Short middle phalanx of the 5th finger (HP:0004220)2.28023677
69Postaxial foot polydactyly (HP:0001830)2.23754176
70Tubulointerstitial fibrosis (HP:0005576)2.23076518
71Conjunctival telangiectasia (HP:0000524)2.22917596
72Recurrent sinusitis (HP:0011108)2.20012271
73Increased density of long bones (HP:0006392)2.14775142
74Stage 5 chronic kidney disease (HP:0003774)2.14663262
75Recurrent bronchitis (HP:0002837)2.14362678
76Thyroid-stimulating hormone excess (HP:0002925)2.13843758
77Renal dysplasia (HP:0000110)2.12210786
78Oculomotor apraxia (HP:0000657)2.09802028
79Hypophosphatemic rickets (HP:0004912)2.08765820
80Absent epiphyses (HP:0010577)2.07102155
81Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.07102155
82Joint hemorrhage (HP:0005261)2.06032442
83Gastrointestinal inflammation (HP:0004386)2.04695304
84Ankyloglossia (HP:0010296)2.03241007
85Biliary tract neoplasm (HP:0100574)2.03196945
86Polydipsia (HP:0001959)2.01940421
87Abnormal drinking behavior (HP:0030082)2.01940421
88Aplasia/Hypoplasia of the fibula (HP:0006492)2.00282568
89Generalized aminoaciduria (HP:0002909)2.00269676
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9899617
91Dynein arm defect of respiratory motile cilia (HP:0012255)10.8509551
92Absent/shortened dynein arms (HP:0200106)10.8509551
93Prolonged bleeding time (HP:0003010)10.0828000
94Facial cleft (HP:0002006)1.98784176
95Congenital hepatic fibrosis (HP:0002612)1.98035132
96Short ribs (HP:0000773)1.97724556
97Tinnitus (HP:0000360)1.95814186
98Xanthomatosis (HP:0000991)1.95439366
99Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.94981820
100Renovascular hypertension (HP:0100817)1.93734421
101Testicular neoplasm (HP:0010788)1.93144491
102Large eyes (HP:0001090)1.90867305
103Hyperthyroidism (HP:0000836)1.90377812
104Transitional cell carcinoma of the bladder (HP:0006740)1.88731941
105Spastic tetraparesis (HP:0001285)1.88635677
106Uterine leiomyosarcoma (HP:0002891)1.87682325
107Leiomyosarcoma (HP:0100243)1.87682325
108Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.82518311
109Chronic sinusitis (HP:0011109)1.82442376
110Heterotopia (HP:0002282)1.81956716
111Abnormality of the renal cortex (HP:0011035)1.80860492
112Bell-shaped thorax (HP:0001591)1.80770389
113Abnormality of the costochondral junction (HP:0000919)1.79117343
114Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77953155
115Abnormality of alanine metabolism (HP:0010916)1.77953155
116Hyperalaninemia (HP:0003348)1.77953155
117Short thorax (HP:0010306)1.76009208
118Increased IgM level (HP:0003496)1.75786332
119Abnormality of ocular smooth pursuit (HP:0000617)1.74814333
120Decreased motor nerve conduction velocity (HP:0003431)1.74531677
121Abnormality of the vasculature of the conjunctiva (HP:0008054)1.74155003
122Cholecystitis (HP:0001082)1.73401016
123Abnormal gallbladder physiology (HP:0012438)1.73401016
124Abnormality of dentin (HP:0010299)1.72712210
125Median cleft lip (HP:0000161)1.71395166
126Urinary urgency (HP:0000012)1.70283678
127Bladder carcinoma (HP:0002862)1.70253236
128Bladder neoplasm (HP:0009725)1.70253236
129Abnormal sex determination (HP:0012244)1.69968358
130Sex reversal (HP:0012245)1.69968358
131Postaxial hand polydactyly (HP:0001162)1.68768820
132Joint swelling (HP:0001386)1.68666532
133Colitis (HP:0002583)1.67446611
134Atrophy/Degeneration involving motor neurons (HP:0007373)1.67116805
135Choroideremia (HP:0001139)1.65149540
136Abnormality of iron homeostasis (HP:0011031)1.64895621
137Facial hemangioma (HP:0000329)1.64452977
138Abnormality of the intrinsic pathway (HP:0010989)1.63262058
139Congenital sensorineural hearing impairment (HP:0008527)1.63065621
140Mitral stenosis (HP:0001718)1.62984186
141Optic nerve hypoplasia (HP:0000609)1.62582396
142Polycythemia (HP:0001901)1.62480449
143Scotoma (HP:0000575)1.61307725
144Supernumerary spleens (HP:0009799)1.59826688
145Intellectual disability, profound (HP:0002187)1.59589981
146Tetraparesis (HP:0002273)1.58410613
147Ectopic kidney (HP:0000086)1.58001768
148Dysautonomia (HP:0002459)1.57769422
149Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.57572592
150Gaze-evoked nystagmus (HP:0000640)1.57546357
151Sensory axonal neuropathy (HP:0003390)1.57473360
152Hepatosplenomegaly (HP:0001433)1.56274163
153Hypoplastic iliac wings (HP:0002866)1.55683971
154Rimmed vacuoles (HP:0003805)1.53879685
155Male pseudohermaphroditism (HP:0000037)1.51662263
156Rickets (HP:0002748)1.50924661
157Cerebellar dysplasia (HP:0007033)1.50886901
158Impaired vibratory sensation (HP:0002495)1.50839332
159Breast carcinoma (HP:0003002)1.50380394
160Short femoral neck (HP:0100864)1.49680368
161Broad distal phalanx of finger (HP:0009836)1.48897579
162Degeneration of the lateral corticospinal tracts (HP:0002314)1.48511070
163Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.48511070
164Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.47342960
165Pachygyria (HP:0001302)1.47052227
166Dyschromatopsia (HP:0007641)1.47004339
167Tongue fasciculations (HP:0001308)1.46840607
168Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.45177336
169Hyporeflexia of lower limbs (HP:0002600)1.44951625
170Difficulty walking (HP:0002355)1.44078907
171Nephropathy (HP:0000112)1.41927859
172Hyperacusis (HP:0010780)1.41652973
173Retinal dysplasia (HP:0007973)1.41279026
174Aplasia/Hypoplasia of the lens (HP:0008063)1.41178345
175Aplasia/Hypoplasia affecting the retina (HP:0008061)1.40570406
176Abnormality of renal excretion (HP:0011036)1.40410402
177Elfin facies (HP:0004428)1.39202914
178Abnormality of permanent molar morphology (HP:0011071)1.35894956
179Abnormality of the dental root (HP:0006486)1.35894956
180Taurodontia (HP:0000679)1.35894956
181Type II lissencephaly (HP:0007260)1.34577086
182Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.34571729
183Neurofibrillary tangles (HP:0002185)1.32274373
184Overriding aorta (HP:0002623)1.31109118

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.27054850
2PDK48.27054850
3TESK16.30755449
4PRKD35.49877817
5PDK25.34049494
6MST45.07337068
7MYLK4.00451778
8ICK3.86526773
9BMX3.28822569
10NEK22.45102146
11PTK2B2.34637095
12BTK2.29644078
13EIF2AK12.21203658
14TEC2.20031575
15VRK12.02277725
16STK381.93023818
17RPS6KA51.87021558
18STK391.75169998
19WNK41.72881801
20BMPR21.68837518
21ILK1.58988011
22FGR1.50941933
23DAPK31.46264762
24PNCK1.36629630
25GRK51.31781271
26TAOK31.28921868
27PIK3CG1.28914578
28PASK1.27230756
29RET1.22946626
30SYK1.19693970
31GRK61.15223018
32AKT31.15155879
33STK31.12078466
34DYRK1B1.08846326
35CDC71.04494140
36MAP3K51.02489720
37ACVR1B1.02247007
38ARAF0.97012003
39HCK0.95319045
40PDK10.92086604
41PKN10.91623668
42ADRBK20.91035646
43PLK20.89654858
44TNIK0.86864668
45CCNB10.85808433
46MAPK150.83743175
47MAPKAPK30.81357866
48PBK0.80754633
49TYRO30.80112157
50DYRK30.79449439
51STK240.78459995
52WNK10.72900715
53TTK0.72564183
54ADRBK10.71402140
55PINK10.69850407
56MAP2K30.68222818
57FES0.68012566
58WEE10.59925699
59ATR0.59796682
60LYN0.59305868
61TESK20.58237587
62PLK30.57793371
63CHEK20.51906004
64EEF2K0.49072362
65CDK140.46450079
66PDPK10.45147197
67IRAK10.44600062
68CAMKK10.43836002
69PIM20.42662482
70NUAK10.41644662
71MAP3K30.41130354
72CHEK10.40631949
73NTRK20.40242667
74ROCK10.39903649
75MUSK0.39734563
76SGK20.39299492
77BMPR1B0.36617580
78MAP2K70.35584899
79PRKD10.35421564
80BRSK20.34625094
81MTOR0.34258753
82MAP3K120.34079101
83TNK20.32763151
84JAK20.32285059
85IKBKB0.30409256
86RIPK40.30225060
87ATM0.30212526
88TLK10.28390877
89MINK10.27307864
90MAPK120.26816513
91FRK0.26604256
92AKT20.26569767
93SGK2230.26518725
94SGK4940.26518725
95RAF10.26288898
96CDK30.26235444
97PRKAA10.25919023
98BLK0.25424691
99BUB10.25184175
100PAK10.24985364
101PLK10.24865350
102MAP3K20.23906807
103RPS6KB10.22159190
104IRAK20.21708308
105TRIB30.21260514
106LMTK20.21078247
107MARK20.20004251
108PAK20.19463220
109TAOK20.18521619
110MATK0.18158080
111TAOK10.18149253
112STK40.17289470
113PRKCG0.16353723
114YES10.14748864
115WNK30.14699671
116PAK60.13479110
117MAPKAPK50.12840574
118PDGFRB0.11795358
119PAK40.10189975
120MAP3K90.09583039
121STK38L0.09568511
122MAP3K100.09094351
123CSF1R0.08826930
124SRPK10.06447394
125RPS6KA10.05811194
126STK110.05183798
127EGFR0.04766620
128BRAF0.03882474
129MET0.03390258
130CDK20.03175024
131ZAP700.02935247
132CDK10.02594584
133CLK10.02433290
134PRKCZ0.02297447
135CAMK1G0.01988694
136MAPK100.01671061
137AURKA0.01492933
138MST1R0.01463242
139MAPK80.01330541
140MAP3K40.01132067
141PRKCQ0.00484665
142PRKACG0.00071617
143PRKCB-0.0369562
144RIPK1-0.0368532
145CDK4-0.0349500
146MARK3-0.0343853
147PRKDC-0.0279418
148ZAK-0.0269943
149PIM1-0.0207846
150PRKG1-0.0188134
151PRKACB-0.0151180
152CDK12-0.0141783
153RPS6KA3-0.0115452
154PTK6-0.0065002
155CSNK2A1-0.0064178
156STK10-0.0057103
157PLK4-0.0047525
158GSK3B-0.0041721
159AURKB-0.0041319
160CSNK1D-0.0011180

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051305.05429103
2Vitamin B6 metabolism_Homo sapiens_hsa007504.97516936
3Platelet activation_Homo sapiens_hsa046114.44123144
4Pyruvate metabolism_Homo sapiens_hsa006204.00066059
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.41822521
6Selenocompound metabolism_Homo sapiens_hsa004503.31917843
7Gap junction_Homo sapiens_hsa045403.20857709
8Fatty acid biosynthesis_Homo sapiens_hsa000613.03941505
9Propanoate metabolism_Homo sapiens_hsa006402.88720784
10Systemic lupus erythematosus_Homo sapiens_hsa053222.88128869
11Dorso-ventral axis formation_Homo sapiens_hsa043202.81788681
12Glucagon signaling pathway_Homo sapiens_hsa049222.78592950
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.71768131
14Pentose phosphate pathway_Homo sapiens_hsa000302.66150361
15Fanconi anemia pathway_Homo sapiens_hsa034602.61392432
16Linoleic acid metabolism_Homo sapiens_hsa005912.58214880
17SNARE interactions in vesicular transport_Homo sapiens_hsa041302.55020541
18Basal transcription factors_Homo sapiens_hsa030222.41916583
19Nitrogen metabolism_Homo sapiens_hsa009102.34098672
20Oocyte meiosis_Homo sapiens_hsa041142.11106074
21Glycerolipid metabolism_Homo sapiens_hsa005612.09607192
22ECM-receptor interaction_Homo sapiens_hsa045122.03856693
23Amphetamine addiction_Homo sapiens_hsa050311.87670831
24Mismatch repair_Homo sapiens_hsa034301.83326388
25Alcoholism_Homo sapiens_hsa050341.72508815
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.65998760
27PPAR signaling pathway_Homo sapiens_hsa033201.62202739
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.58022252
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.57909273
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.49878387
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.49337425
32RNA transport_Homo sapiens_hsa030131.46469207
33Fat digestion and absorption_Homo sapiens_hsa049751.45728378
34Chemokine signaling pathway_Homo sapiens_hsa040621.38397727
35Carbon metabolism_Homo sapiens_hsa012001.37431645
36Hematopoietic cell lineage_Homo sapiens_hsa046401.36694873
37Serotonergic synapse_Homo sapiens_hsa047261.30142082
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.29570297
39Renin secretion_Homo sapiens_hsa049241.26725487
40Apoptosis_Homo sapiens_hsa042101.24717275
41Fructose and mannose metabolism_Homo sapiens_hsa000511.24170307
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22625848
43Olfactory transduction_Homo sapiens_hsa047401.20094456
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.19118777
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18899007
46Long-term potentiation_Homo sapiens_hsa047201.18532761
47Ether lipid metabolism_Homo sapiens_hsa005651.18272008
48Huntingtons disease_Homo sapiens_hsa050161.16529216
49Fatty acid metabolism_Homo sapiens_hsa012121.11300130
50Antigen processing and presentation_Homo sapiens_hsa046121.10048274
51Fatty acid degradation_Homo sapiens_hsa000711.04890535
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04114745
53ABC transporters_Homo sapiens_hsa020101.03713559
54mRNA surveillance pathway_Homo sapiens_hsa030150.98248518
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96944494
56Phagosome_Homo sapiens_hsa041450.96624099
57Viral carcinogenesis_Homo sapiens_hsa052030.94864345
58Thyroid cancer_Homo sapiens_hsa052160.93870484
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92423443
60Choline metabolism in cancer_Homo sapiens_hsa052310.90103276
61Focal adhesion_Homo sapiens_hsa045100.89862291
62Homologous recombination_Homo sapiens_hsa034400.88752761
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88394399
64Biosynthesis of amino acids_Homo sapiens_hsa012300.88392744
65Non-small cell lung cancer_Homo sapiens_hsa052230.86198267
66Estrogen signaling pathway_Homo sapiens_hsa049150.85529053
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85081013
68Endometrial cancer_Homo sapiens_hsa052130.84378492
69Cardiac muscle contraction_Homo sapiens_hsa042600.84238848
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.83824160
71Shigellosis_Homo sapiens_hsa051310.83783501
72Glutathione metabolism_Homo sapiens_hsa004800.80700739
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78878425
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77664532
75Melanoma_Homo sapiens_hsa052180.77060348
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75496147
77Sulfur relay system_Homo sapiens_hsa041220.73322456
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72538563
79Regulation of autophagy_Homo sapiens_hsa041400.72079465
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.71775860
81VEGF signaling pathway_Homo sapiens_hsa043700.69365991
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67932426
83Small cell lung cancer_Homo sapiens_hsa052220.66740598
84Pancreatic secretion_Homo sapiens_hsa049720.65858804
85T cell receptor signaling pathway_Homo sapiens_hsa046600.64645032
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.62996263
87Long-term depression_Homo sapiens_hsa047300.62263363
88AMPK signaling pathway_Homo sapiens_hsa041520.61205313
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58267933
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.57880950
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57451917
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57151349
93DNA replication_Homo sapiens_hsa030300.56632378
94Purine metabolism_Homo sapiens_hsa002300.56469982
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55892679
96Legionellosis_Homo sapiens_hsa051340.55044857
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54162085
98Glioma_Homo sapiens_hsa052140.53616123
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49619298
100Hedgehog signaling pathway_Homo sapiens_hsa043400.49334065
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48768408
102Endocytosis_Homo sapiens_hsa041440.48121551
103Arachidonic acid metabolism_Homo sapiens_hsa005900.47716971
104Prostate cancer_Homo sapiens_hsa052150.46223902
105Chemical carcinogenesis_Homo sapiens_hsa052040.45595599
106Sphingolipid metabolism_Homo sapiens_hsa006000.44028861
107Pancreatic cancer_Homo sapiens_hsa052120.43114267
108Rap1 signaling pathway_Homo sapiens_hsa040150.42292053
109N-Glycan biosynthesis_Homo sapiens_hsa005100.42069837
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40254230
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38982029
112Morphine addiction_Homo sapiens_hsa050320.38106498
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38007559
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.37394812
115Calcium signaling pathway_Homo sapiens_hsa040200.37079145
116Inositol phosphate metabolism_Homo sapiens_hsa005620.36327959
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.36233587
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35379363
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35372263
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35200252
121Renin-angiotensin system_Homo sapiens_hsa046140.34366644
122Fatty acid elongation_Homo sapiens_hsa000620.33175635
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33160705
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.32750595
125Nucleotide excision repair_Homo sapiens_hsa034200.31954490
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31925418
127B cell receptor signaling pathway_Homo sapiens_hsa046620.31205051
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30655003
129Steroid biosynthesis_Homo sapiens_hsa001000.29843930
130Cell cycle_Homo sapiens_hsa041100.29617935
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28768308
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.28430328
133Oxytocin signaling pathway_Homo sapiens_hsa049210.28021826
134Ras signaling pathway_Homo sapiens_hsa040140.27591795
135Mineral absorption_Homo sapiens_hsa049780.27083409
136Circadian entrainment_Homo sapiens_hsa047130.26426683
137Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25704372
138Pathways in cancer_Homo sapiens_hsa052000.24977648
139Phototransduction_Homo sapiens_hsa047440.24589328
140Bile secretion_Homo sapiens_hsa049760.24571837
141TGF-beta signaling pathway_Homo sapiens_hsa043500.24229809
142Thyroid hormone synthesis_Homo sapiens_hsa049180.23560823
143Pyrimidine metabolism_Homo sapiens_hsa002400.23451794
144Basal cell carcinoma_Homo sapiens_hsa052170.23437194
145Metabolic pathways_Homo sapiens_hsa011000.22114030
146Insulin secretion_Homo sapiens_hsa049110.22055681
147NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21972088
148Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21576338
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21373411
150Wnt signaling pathway_Homo sapiens_hsa043100.20953370
151Cocaine addiction_Homo sapiens_hsa050300.19289222
152Glutamatergic synapse_Homo sapiens_hsa047240.18216942
153RNA degradation_Homo sapiens_hsa030180.17510417
154Retinol metabolism_Homo sapiens_hsa008300.16778497
155Synaptic vesicle cycle_Homo sapiens_hsa047210.16582542
156Gastric acid secretion_Homo sapiens_hsa049710.16047735
157Insulin resistance_Homo sapiens_hsa049310.15273566
158Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.15190730
159HIF-1 signaling pathway_Homo sapiens_hsa040660.14957300
160Peroxisome_Homo sapiens_hsa041460.14925804
161Sulfur metabolism_Homo sapiens_hsa009200.14847164
162Salmonella infection_Homo sapiens_hsa051320.14699222
163Collecting duct acid secretion_Homo sapiens_hsa049660.12403832

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