HIST1H2AA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptonemal complex assembly (GO:0007130)8.72144399
2synaptonemal complex organization (GO:0070193)8.55053462
3male meiosis (GO:0007140)8.20615414
4binding of sperm to zona pellucida (GO:0007339)7.78916213
5sperm-egg recognition (GO:0035036)7.66037629
6DNA methylation involved in gamete generation (GO:0043046)7.50610385
7positive regulation of catecholamine secretion (GO:0033605)7.32845525
8negative regulation of retinoic acid receptor signaling pathway (GO:0048387)7.10786553
9cell wall macromolecule catabolic process (GO:0016998)6.92146567
10cell wall macromolecule metabolic process (GO:0044036)6.92146567
11sperm motility (GO:0030317)6.91480503
12cell-cell recognition (GO:0009988)6.85324733
13acrosome assembly (GO:0001675)6.83275169
14fusion of sperm to egg plasma membrane (GO:0007342)6.80917696
15regulation of phosphoprotein phosphatase activity (GO:0043666)6.75601404
16multicellular organism reproduction (GO:0032504)6.39451814
17histone H3-K9 demethylation (GO:0033169)6.38561619
18spermatid development (GO:0007286)6.34936349
19axonemal dynein complex assembly (GO:0070286)6.28223660
20chromosome organization involved in meiosis (GO:0070192)6.27507049
21acrosome reaction (GO:0007340)6.21288926
22regulation of retinoic acid receptor signaling pathway (GO:0048385)6.10403634
23cilium or flagellum-dependent cell motility (GO:0001539)6.06764940
24motile cilium assembly (GO:0044458)5.83943268
25meiotic nuclear division (GO:0007126)5.73623237
26male meiosis I (GO:0007141)5.67014344
27positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.38239878
28epithelial cilium movement (GO:0003351)5.28687752
29regulation of meiosis I (GO:0060631)5.24558081
30reproduction (GO:0000003)5.22720908
31meiotic cell cycle (GO:0051321)5.22710391
32DNA packaging (GO:0006323)5.20774327
33chromosome condensation (GO:0030261)5.20133154
34relaxation of smooth muscle (GO:0044557)5.10737684
35plasma membrane fusion (GO:0045026)4.98209969
36spermatogenesis (GO:0007283)4.90317666
37meiosis I (GO:0007127)4.89314984
38male gamete generation (GO:0048232)4.89250383
39fertilization (GO:0009566)4.75623160
40polyamine biosynthetic process (GO:0006596)4.66755794
41gamete generation (GO:0007276)4.61928478
42potassium ion export (GO:0071435)4.61877346
43rRNA catabolic process (GO:0016075)4.56941296
44regulation of oxidative phosphorylation (GO:0002082)4.52765921
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.51580116
46germ cell development (GO:0007281)4.50633720
47nuclear pore complex assembly (GO:0051292)4.48831228
48regulation of cilium movement (GO:0003352)4.43891706
49meiotic cell cycle process (GO:1903046)4.41019925
50regulation of oxidative stress-induced neuron death (GO:1903203)4.40385233
51cilium movement (GO:0003341)4.39668706
52cellular process involved in reproduction in multicellular organism (GO:0022412)4.39540370
53DNA replication-dependent nucleosome organization (GO:0034723)4.39134498
54DNA replication-dependent nucleosome assembly (GO:0006335)4.39134498
55single fertilization (GO:0007338)4.34053822
56negative regulation of inclusion body assembly (GO:0090084)4.31504242
57gene silencing by RNA (GO:0031047)4.30808045
58histone exchange (GO:0043486)4.26322288
59microtubule depolymerization (GO:0007019)4.21265467
60DNA methylation (GO:0006306)4.18465647
61DNA alkylation (GO:0006305)4.18465647
62male sex determination (GO:0030238)4.16749202
63DNA synthesis involved in DNA repair (GO:0000731)4.09834064
64seminiferous tubule development (GO:0072520)4.08594356
65calcium ion-dependent exocytosis (GO:0017156)4.07273383
66nuclear pore organization (GO:0006999)4.02432252
67protein localization to chromosome, centromeric region (GO:0071459)3.94402872
68protein-DNA complex disassembly (GO:0032986)3.84074732
69nucleosome disassembly (GO:0006337)3.84074732
70regulation of spindle checkpoint (GO:0090231)3.77392888
71centriole assembly (GO:0098534)3.76421307
72regulation of acrosome reaction (GO:0060046)3.75787861
73regulation of histone H3-K9 methylation (GO:0051570)3.75285130
74centriole replication (GO:0007099)3.71057097
75attachment of spindle microtubules to kinetochore (GO:0008608)3.71039224
76labyrinthine layer development (GO:0060711)3.68921845
77Leydig cell differentiation (GO:0033327)3.66803675
78multicellular organismal reproductive process (GO:0048609)3.61080466
79regulation of inclusion body assembly (GO:0090083)3.60413984
80response to acidic pH (GO:0010447)3.58247305
81regulation of centriole replication (GO:0046599)3.57227339
82cellular biogenic amine biosynthetic process (GO:0042401)3.55117797
83pore complex assembly (GO:0046931)3.53652465
84TOR signaling (GO:0031929)3.49328954
85amine biosynthetic process (GO:0009309)3.48699966
86spermatid nucleus differentiation (GO:0007289)3.48582741
87synapsis (GO:0007129)3.48205205
88negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.48050745
89microtubule severing (GO:0051013)3.45203523
90gene silencing (GO:0016458)3.43842631
91mitotic chromosome condensation (GO:0007076)3.43470847
92organic cation transport (GO:0015695)3.40364566
93protein K6-linked ubiquitination (GO:0085020)3.38837503
94sequestering of actin monomers (GO:0042989)3.37220164
95kinetochore organization (GO:0051383)3.36688721
96meiotic chromosome segregation (GO:0045132)3.36363752
97cGMP-mediated signaling (GO:0019934)3.36283538
98genitalia morphogenesis (GO:0035112)3.35564345
99chaperone-mediated protein complex assembly (GO:0051131)3.35143802
100mitotic sister chromatid segregation (GO:0000070)3.33546623
101inner cell mass cell proliferation (GO:0001833)3.30574113
102mitotic sister chromatid cohesion (GO:0007064)3.29173519
103DNA methylation or demethylation (GO:0044728)3.26478109
104activation of protein kinase B activity (GO:0032148)3.24563400
105regulation of hydrogen peroxide-induced cell death (GO:1903205)3.24259623
106androgen biosynthetic process (GO:0006702)3.23987492
107DNA double-strand break processing (GO:0000729)3.22762822
108oocyte maturation (GO:0001556)3.21969545
109chromosome organization (GO:0051276)3.20152023
110negative regulation of meiosis (GO:0045835)3.19965172
111reciprocal DNA recombination (GO:0035825)3.16515268
112reciprocal meiotic recombination (GO:0007131)3.16515268
113coenzyme catabolic process (GO:0009109)3.16435596
114detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.16196327
115resolution of meiotic recombination intermediates (GO:0000712)3.15461732
116negative regulation of response to reactive oxygen species (GO:1901032)3.14960076
117positive regulation of meiotic cell cycle (GO:0051446)3.14613108
118tongue development (GO:0043586)3.14456927
119mitochondrion degradation (GO:0000422)3.12881855
120oocyte development (GO:0048599)3.12819845
121chromatin remodeling at centromere (GO:0031055)3.11912723
122ventricular system development (GO:0021591)3.09847490
123regulation of female gonad development (GO:2000194)3.08460402
124histone lysine demethylation (GO:0070076)3.07539252
125ncRNA catabolic process (GO:0034661)3.05820293
126gonadal mesoderm development (GO:0007506)3.05024874
127negative regulation of metanephros development (GO:0072217)3.04795917
128mitotic nuclear envelope disassembly (GO:0007077)3.04440009
129kinetochore assembly (GO:0051382)3.04367341
130oogenesis (GO:0048477)3.02005808
131sex differentiation (GO:0007548)3.01908129
132regulation of DNA methylation (GO:0044030)3.00895956
133poly(A)+ mRNA export from nucleus (GO:0016973)3.00321568
134nucleus organization (GO:0006997)2.99125230
135protein polymerization (GO:0051258)2.98532031
136nucleosome assembly (GO:0006334)2.97503699
137regulation of cellular respiration (GO:0043457)2.97336527
138regulation of chromosome segregation (GO:0051983)2.96854075
139mitotic metaphase plate congression (GO:0007080)2.96675059
140sperm capacitation (GO:0048240)2.95585954
141phosphatidylethanolamine biosynthetic process (GO:0006646)2.94728282
142histone demethylation (GO:0016577)2.94428668
143regulation of centrosome cycle (GO:0046605)2.94352763
144female gamete generation (GO:0007292)2.91042649
145DNA modification (GO:0006304)2.90361971
146protein localization to chromosome (GO:0034502)2.88579898
147sister chromatid cohesion (GO:0007062)2.88273557
148protein polyglutamylation (GO:0018095)2.88055235
149piRNA metabolic process (GO:0034587)10.4169882

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.97017735
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.31751335
3E2F7_22180533_ChIP-Seq_HELA_Human5.13270950
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.61595880
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.14790221
6IGF1R_20145208_ChIP-Seq_DFB_Human3.67801307
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.24657142
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.94326182
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.84856777
10CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.58522646
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.46788332
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.46258794
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.44343061
14AR_21909140_ChIP-Seq_LNCAP_Human2.35308646
15VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.25137570
16EZH2_22144423_ChIP-Seq_EOC_Human2.23991664
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23847624
18GATA1_26923725_Chip-Seq_HPCs_Mouse2.19911338
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.15414892
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.10043370
21ESR1_20079471_ChIP-ChIP_T-47D_Human2.08679437
22FUS_26573619_Chip-Seq_HEK293_Human2.03156002
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96468862
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92808471
25IRF1_19129219_ChIP-ChIP_H3396_Human1.77568028
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77182588
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.72900899
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.72446425
29GBX2_23144817_ChIP-Seq_PC3_Human1.69157378
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.68020099
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65392489
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.65096969
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.62339417
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61154427
35CBP_20019798_ChIP-Seq_JUKART_Human1.61154427
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59522366
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59522366
38* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57290274
39VDR_22108803_ChIP-Seq_LS180_Human1.55963438
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53277638
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.51822618
42ER_23166858_ChIP-Seq_MCF-7_Human1.51633931
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51305456
44* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51058394
45KAP1_22055183_ChIP-Seq_ESCs_Mouse1.47936398
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40009385
47ERA_21632823_ChIP-Seq_H3396_Human1.39463367
48KLF5_20875108_ChIP-Seq_MESCs_Mouse1.39186211
49AUTS2_25519132_ChIP-Seq_293T-REX_Human1.39186037
50FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38134078
51GATA3_21867929_ChIP-Seq_CD8_Mouse1.34736745
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34650047
53MYC_18940864_ChIP-ChIP_HL60_Human1.32132274
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31614125
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.30497555
56P300_19829295_ChIP-Seq_ESCs_Human1.29483033
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29169410
58RUNX2_22187159_ChIP-Seq_PCA_Human1.27818502
59* RAC3_21632823_ChIP-Seq_H3396_Human1.26458770
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.25342718
61CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.24128478
62SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23373352
63TBL1_22424771_ChIP-Seq_293T_Human1.21969640
64XRN2_22483619_ChIP-Seq_HELA_Human1.20773205
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.20687633
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19827099
67ELK4_26923725_Chip-Seq_MESODERM_Mouse1.19531007
68SMAD4_21799915_ChIP-Seq_A2780_Human1.18614537
69FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18449764
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17855469
71MYC_19079543_ChIP-ChIP_MESCs_Mouse1.17760026
72SMAD4_21741376_ChIP-Seq_EPCs_Human1.16994148
73AR_25329375_ChIP-Seq_VCAP_Human1.16540270
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.16189680
75SOX2_22085726_ChIP-Seq_NPCs_Mouse1.15619888
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15492558
77MYC_19829295_ChIP-Seq_ESCs_Human1.15323652
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15316398
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.15275357
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.13903538
81ZNF274_21170338_ChIP-Seq_K562_Hela1.12396185
82* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11315082
83SOX2_19829295_ChIP-Seq_ESCs_Human1.10994260
84NANOG_19829295_ChIP-Seq_ESCs_Human1.10994260
85OCT4_20526341_ChIP-Seq_ESCs_Human1.10949751
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.10109006
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09909271
88VDR_23849224_ChIP-Seq_CD4+_Human1.09022635
89CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08471542
90RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08163022
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07539957
92AHR_22903824_ChIP-Seq_MCF-7_Human1.07484100
93CTCF_20526341_ChIP-Seq_ESCs_Human1.07184114
94ETS1_20019798_ChIP-Seq_JURKAT_Human1.06996911
95SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.06485152
96NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05364324
97HOXB7_26014856_ChIP-Seq_BT474_Human1.04992542
98OCT1_27270436_Chip-Seq_PROSTATE_Human1.03646782
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03585506
100PHF8_20622854_ChIP-Seq_HELA_Human1.02612918
101TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.02593526
102STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02402838
103LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02162230
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02064104
105BCAT_22108803_ChIP-Seq_LS180_Human1.01955562
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01379673
107YY1_22570637_ChIP-Seq_MALME-3M_Human1.01132434
108FOXH1_21741376_ChIP-Seq_EPCs_Human1.00539682
109GABP_19822575_ChIP-Seq_HepG2_Human1.00393988
110KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00112585
111CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00103524
112STAT3_23295773_ChIP-Seq_U87_Human0.99372185
113RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97921076
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97375642
115SMAD3_21741376_ChIP-Seq_EPCs_Human0.97192149
116* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96661662
117CTCF_26484167_Chip-Seq_Bcells_Mouse0.96441114
118PHF8_20622853_ChIP-Seq_HELA_Human0.96190918
119LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95770148
120EST1_17652178_ChIP-ChIP_JURKAT_Human0.95294227
121RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95208683
122POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95205893
123RARA_24833708_ChIP-Seq_LIVER_Mouse0.95170448
124RBPJ_21746931_ChIP-Seq_IB4_Human0.94987825
125STAT1_17558387_ChIP-Seq_HELA_Human0.94799842
126SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94541551
127ERG_20517297_ChIP-Seq_VCAP_Human0.93273137
128SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93239717
129EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.93227951
130AR_21572438_ChIP-Seq_LNCaP_Human0.93103540
131DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91869699
132NFYB_21822215_ChIP-Seq_K562_Human0.91467880
133KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.91382195
134KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.91382195
135KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.91382195
136TCF4_23295773_ChIP-Seq_U87_Human0.91193364
137PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91139209
138NCOR_22424771_ChIP-Seq_293T_Human0.90980624
139TTF2_22483619_ChIP-Seq_HELA_Human0.90944075
140CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90710236
141E2F1_17053090_ChIP-ChIP_MCF-7_Human0.90697459
142CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.90110911
143ETV1_20927104_ChIP-Seq_GIST48_Human0.89924784
144ELF1_20517297_ChIP-Seq_JURKAT_Human0.89868678
145KDM5A_27292631_Chip-Seq_BREAST_Human0.89717686
146FOXP3_21729870_ChIP-Seq_TREG_Human0.89133530
147GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88001298
148FLI1_27457419_Chip-Seq_LIVER_Mouse0.87633988
149PKCTHETA_26484144_Chip-Seq_BREAST_Human0.87587232
150SALL1_21062744_ChIP-ChIP_HESCs_Human0.86684984
151P53_21459846_ChIP-Seq_SAOS-2_Human0.86473558
152RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86454981
153EWS_26573619_Chip-Seq_HEK293_Human0.86255186
154CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84765419
155SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84221424
156OCT4_19829295_ChIP-Seq_ESCs_Human0.84125815
157FLI1_21867929_ChIP-Seq_CD8_Mouse0.84058196
158HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83348365
159TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83307244
160CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.83090761
161ZFX_18555785_ChIP-Seq_MESCs_Mouse0.82702693
162GATA3_21867929_ChIP-Seq_TH1_Mouse0.82623970
163CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82053919
164GABP_17652178_ChIP-ChIP_JURKAT_Human0.81821505
165EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.81210359
166HNFA_21074721_ChIP-Seq_CACO-2_Human0.80597479
167CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79944269
168ELF5_23300383_ChIP-Seq_T47D_Human0.79408392
169P300_27268052_Chip-Seq_Bcells_Human0.78628553
170HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.78477149
171WDR5_24793694_ChIP-Seq_LNCAP_Human0.78271610
172BCOR_27268052_Chip-Seq_Bcells_Human0.77211917
173NANOG_20526341_ChIP-Seq_ESCs_Human0.77107956
174DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77095669
175EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.76985119

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.29869730
2MP0008877_abnormal_DNA_methylation5.97105026
3MP0001929_abnormal_gametogenesis4.79306689
4MP0003698_abnormal_male_reproductive4.29329092
5MP0008004_abnormal_stomach_pH4.27485163
6MP0002210_abnormal_sex_determination3.84738738
7MP0010094_abnormal_chromosome_stability3.43490186
8MP0005360_urolithiasis3.23919587
9MP0001145_abnormal_male_reproductive3.16476023
10MP0002653_abnormal_ependyma_morphology3.10126507
11MP0008057_abnormal_DNA_replication3.05810179
12MP0003693_abnormal_embryo_hatching3.03723992
13MP0000653_abnormal_sex_gland3.02064426
14MP0003111_abnormal_nucleus_morphology2.79233632
15MP0003283_abnormal_digestive_organ2.78877554
16MP0003718_maternal_effect2.78351081
17MP0002161_abnormal_fertility/fecundity2.67155637
18MP0004957_abnormal_blastocyst_morpholog2.63885146
19MP0003646_muscle_fatigue2.51560686
20MP0005394_taste/olfaction_phenotype2.40560383
21MP0005499_abnormal_olfactory_system2.40560383
22MP0003077_abnormal_cell_cycle2.38021908
23MP0002160_abnormal_reproductive_system2.24902184
24MP0008058_abnormal_DNA_repair2.17057978
25MP0008007_abnormal_cellular_replicative2.09183439
26MP0006292_abnormal_olfactory_placode1.95689213
27MP0005670_abnormal_white_adipose1.95148548
28MP0008789_abnormal_olfactory_epithelium1.93590627
29MP0003136_yellow_coat_color1.89981367
30MP0001984_abnormal_olfaction1.89633790
31MP0000678_abnormal_parathyroid_gland1.79245568
32MP0003878_abnormal_ear_physiology1.75824037
33MP0005377_hearing/vestibular/ear_phenot1.75824037
34MP0001730_embryonic_growth_arrest1.71080205
35MP0008932_abnormal_embryonic_tissue1.64636256
36MP0003786_premature_aging1.63079730
37MP0003315_abnormal_perineum_morphology1.61132653
38MP0001664_abnormal_digestion1.46168035
39MP0005389_reproductive_system_phenotype1.43382437
40MP0003699_abnormal_female_reproductive1.42004539
41MP0002132_abnormal_respiratory_system1.38421665
42MP0000462_abnormal_digestive_system1.37991516
43MP0001119_abnormal_female_reproductive1.34268765
44MP0003045_fibrosis1.33299350
45MP0010368_abnormal_lymphatic_system1.32795098
46MP0004264_abnormal_extraembryonic_tissu1.30376885
47MP0010307_abnormal_tumor_latency1.27772751
48MP0000350_abnormal_cell_proliferation1.25908174
49MP0003806_abnormal_nucleotide_metabolis1.23324502
50MP0001672_abnormal_embryogenesis/_devel1.21107204
51MP0005380_embryogenesis_phenotype1.21107204
52MP0003121_genomic_imprinting1.19597947
53MP0003787_abnormal_imprinting1.19597333
54MP0000537_abnormal_urethra_morphology1.18514160
55MP0009697_abnormal_copulation1.16755069
56MP0001697_abnormal_embryo_size1.15837552
57MP0002085_abnormal_embryonic_tissue1.15363977
58MP0001986_abnormal_taste_sensitivity1.13189361
59MP0010386_abnormal_urinary_bladder1.10365914
60MP0002127_abnormal_cardiovascular_syste1.06949298
61MP0002084_abnormal_developmental_patter1.05614313
62MP0008995_early_reproductive_senescence1.04724052
63MP0010030_abnormal_orbit_morphology1.03180396
64MP0006276_abnormal_autonomic_nervous1.02795255
65MP0005395_other_phenotype0.97928556
66MP0000313_abnormal_cell_death0.97300271
67MP0001905_abnormal_dopamine_level0.97099699
68MP0005646_abnormal_pituitary_gland0.96585660
69MP0003123_paternal_imprinting0.96344339
70MP0004233_abnormal_muscle_weight0.95425343
71MP0005266_abnormal_metabolism0.91830877
72MP0003984_embryonic_growth_retardation0.90451400
73MP0002080_prenatal_lethality0.87226764
74MP0000631_abnormal_neuroendocrine_gland0.86040810
75MP0000049_abnormal_middle_ear0.84784792
76MP0000490_abnormal_crypts_of0.84632035
77MP0002088_abnormal_embryonic_growth/wei0.84404713
78MP0005058_abnormal_lysosome_morphology0.82410813
79MP0005423_abnormal_somatic_nervous0.81364683
80MP0002233_abnormal_nose_morphology0.80824766
81MP0004808_abnormal_hematopoietic_stem0.80267094
82MP0001661_extended_life_span0.79420438
83MP0001293_anophthalmia0.78285558
84MP0002019_abnormal_tumor_incidence0.75048417
85MP0001545_abnormal_hematopoietic_system0.73452399
86MP0005397_hematopoietic_system_phenotyp0.73452399
87MP0005253_abnormal_eye_physiology0.72796193
88MP0002086_abnormal_extraembryonic_tissu0.71791188
89MP0002234_abnormal_pharynx_morphology0.71324029
90MP0003119_abnormal_digestive_system0.69761013
91MP0002822_catalepsy0.69565487
92MP0010352_gastrointestinal_tract_polyps0.68553865
93MP0002249_abnormal_larynx_morphology0.68536023
94MP0003937_abnormal_limbs/digits/tail_de0.67818317
95MP0000538_abnormal_urinary_bladder0.67391136
96MP0004197_abnormal_fetal_growth/weight/0.67294913
97MP0000358_abnormal_cell_content/0.66523993
98MP0003936_abnormal_reproductive_system0.65945269
99MP0005551_abnormal_eye_electrophysiolog0.62613775
100MP0001666_abnormal_nutrient_absorption0.62179699
101MP0000470_abnormal_stomach_morphology0.60806875
102MP0003115_abnormal_respiratory_system0.59287759
103MP0000477_abnormal_intestine_morphology0.58079764
104MP0003938_abnormal_ear_development0.57152534
105MP0009672_abnormal_birth_weight0.57137682
106MP0005187_abnormal_penis_morphology0.56799784
107MP0003861_abnormal_nervous_system0.56433328
108MP0009278_abnormal_bone_marrow0.54396356
109MP0000762_abnormal_tongue_morphology0.53727814
110MP0002272_abnormal_nervous_system0.53645552
111MP0000427_abnormal_hair_cycle0.53030201
112MP0002102_abnormal_ear_morphology0.52803899
113MP0002138_abnormal_hepatobiliary_system0.52451603
114MP0004085_abnormal_heartbeat0.52444531
115MP0001501_abnormal_sleep_pattern0.52243846
116MP0002139_abnormal_hepatobiliary_system0.51409437
117MP0002269_muscular_atrophy0.51374463
118MP0008875_abnormal_xenobiotic_pharmacok0.51206995
119MP0001502_abnormal_circadian_rhythm0.50731840
120MP0003950_abnormal_plasma_membrane0.49055894
121MP0005076_abnormal_cell_differentiation0.47883822
122MP0002282_abnormal_trachea_morphology0.47762466
123MP0005623_abnormal_meninges_morphology0.46696190
124MP0003632_abnormal_nervous_system0.46271610
125MP0003868_abnormal_feces_composition0.46254895
126MP0003186_abnormal_redox_activity0.46117946
127MP0001915_intracranial_hemorrhage0.45759180
128MP0001873_stomach_inflammation0.45276564
129MP0001919_abnormal_reproductive_system0.44509630
130MP0003890_abnormal_embryonic-extraembry0.44360029
131MP0001963_abnormal_hearing_physiology0.43920677
132MP0005391_vision/eye_phenotype0.43190259
133MP0003879_abnormal_hair_cell0.43051219
134MP0005384_cellular_phenotype0.42126794
135MP0001485_abnormal_pinna_reflex0.41488387
136MP0002092_abnormal_eye_morphology0.39795056
137MP0004084_abnormal_cardiac_muscle0.39681911
138MP0006072_abnormal_retinal_apoptosis0.38569799
139MP0005666_abnormal_adipose_tissue0.38443810
140MP0000733_abnormal_muscle_development0.37946720
141MP0005647_abnormal_sex_gland0.37414112
142MP0009703_decreased_birth_body0.37078234
143MP0005621_abnormal_cell_physiology0.37014821
144MP0004036_abnormal_muscle_relaxation0.37013065
145MP0000627_abnormal_mammary_gland0.36859006
146MP0000516_abnormal_urinary_system0.36498263
147MP0005367_renal/urinary_system_phenotyp0.36498263
148MP0001529_abnormal_vocalization0.36403349
149MP0000026_abnormal_inner_ear0.36355743
150MP0002751_abnormal_autonomic_nervous0.36123436
151MP0001764_abnormal_homeostasis0.36067411
152MP0000432_abnormal_head_morphology0.35716599
153MP0002697_abnormal_eye_size0.35491151
154MP0006036_abnormal_mitochondrial_physio0.33863011

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)7.69572069
2Absent/shortened dynein arms (HP:0200106)7.69572069
3Chronic bronchitis (HP:0004469)6.63386676
4Abnormal respiratory motile cilium physiology (HP:0012261)6.51191097
5Abnormal sex determination (HP:0012244)6.47740738
6Sex reversal (HP:0012245)6.47740738
7Hypoplasia of the uterus (HP:0000013)6.23772608
8Rhinitis (HP:0012384)5.80962910
9Abnormal respiratory epithelium morphology (HP:0012253)5.64313718
10Abnormal respiratory motile cilium morphology (HP:0005938)5.64313718
11Impulsivity (HP:0100710)5.53897679
12Aplasia/hypoplasia of the uterus (HP:0008684)5.16594269
13Infertility (HP:0000789)5.09835722
14Resting tremor (HP:0002322)5.09196689
15Gonadal dysgenesis (HP:0000133)4.89588945
16Male pseudohermaphroditism (HP:0000037)4.70769423
17Facial hemangioma (HP:0000329)4.56159246
18Nasal polyposis (HP:0100582)4.42056881
19Abnormality of the 1st metacarpal (HP:0010009)4.30437255
20Abnormal ciliary motility (HP:0012262)4.22646278
21Abnormal spermatogenesis (HP:0008669)3.83492311
22Nephronophthisis (HP:0000090)3.68165427
23Ventricular fibrillation (HP:0001663)3.61436363
24Reduced antithrombin III activity (HP:0001976)3.61003933
25Abnormality of the phalanges of the hallux (HP:0010057)3.58832303
26Short phalanx of the thumb (HP:0009660)3.57747184
27Gonadotropin excess (HP:0000837)3.47216818
28Bronchitis (HP:0012387)3.46777263
29Bronchiectasis (HP:0002110)3.44700972
30Abnormality of the nasal mucosa (HP:0000433)3.44147478
31Azoospermia (HP:0000027)3.42633590
32Median cleft lip (HP:0000161)3.37831462
33Degeneration of anterior horn cells (HP:0002398)3.28794501
34Abnormality of the anterior horn cell (HP:0006802)3.28794501
35Sensory axonal neuropathy (HP:0003390)3.23991255
36Capillary hemangiomas (HP:0005306)3.20425870
37Abnormality of the lower motor neuron (HP:0002366)3.17766481
38Postural instability (HP:0002172)3.11327440
39Cerebellar dysplasia (HP:0007033)3.03162150
40Abnormality of male internal genitalia (HP:0000022)2.99089370
41Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.98344762
42Short 1st metacarpal (HP:0010034)2.98344762
43Premature ovarian failure (HP:0008209)2.85657858
44Abnormality of the columella (HP:0009929)2.79499322
45Male infertility (HP:0003251)2.76394762
46Germ cell neoplasia (HP:0100728)2.74695588
47Selective tooth agenesis (HP:0001592)2.73163364
48Amyotrophic lateral sclerosis (HP:0007354)2.72196281
49Chromsome breakage (HP:0040012)2.71616246
5011 pairs of ribs (HP:0000878)2.71468555
51Pustule (HP:0200039)2.69885096
52Abnormality of midbrain morphology (HP:0002418)2.68278213
53Molar tooth sign on MRI (HP:0002419)2.68278213
54Absent thumb (HP:0009777)2.66051165
55Abnormality of the renal medulla (HP:0100957)2.62527988
56Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.58583988
57Retinal atrophy (HP:0001105)2.58383876
58Oligodactyly (hands) (HP:0001180)2.52902587
59Abnormality of the distal phalanx of the thumb (HP:0009617)2.51664633
60Congenital sensorineural hearing impairment (HP:0008527)2.51584078
61Type II lissencephaly (HP:0007260)2.50832626
62Atonic seizures (HP:0010819)2.50661991
63Chromosomal breakage induced by crosslinking agents (HP:0003221)2.50611225
64Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.48851814
65Abnormality of the preputium (HP:0100587)2.46656025
66Anterior segment dysgenesis (HP:0007700)2.43158647
67Recurrent otitis media (HP:0000403)2.38953035
68Abnormality of the intrinsic pathway (HP:0010989)2.35217479
69Small intestinal stenosis (HP:0012848)2.32611323
70Duodenal stenosis (HP:0100867)2.32611323
71Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.25724357
72Short thumb (HP:0009778)2.25433617
73Colitis (HP:0002583)2.24915645
74Short femoral neck (HP:0100864)2.24846884
75Retinal dysplasia (HP:0007973)2.23493896
76Tubular atrophy (HP:0000092)2.23219628
77Fibular hypoplasia (HP:0003038)2.22404686
78Hypoplasia of the capital femoral epiphysis (HP:0003090)2.21997792
79Supernumerary spleens (HP:0009799)2.21062197
80Short tibia (HP:0005736)2.19969772
81Urinary urgency (HP:0000012)2.17950348
82Occipital encephalocele (HP:0002085)2.16654426
83Clubbing of toes (HP:0100760)2.15449551
84Abnormality of the epiphysis of the femoral head (HP:0010574)2.14589668
85Short ribs (HP:0000773)2.14433123
86Sandal gap (HP:0001852)2.13632979
87Tubulointerstitial nephritis (HP:0001970)2.12662896
88Abnormality of the labia minora (HP:0012880)2.12625118
89Absent rod-and cone-mediated responses on ERG (HP:0007688)2.10158088
90Abnormality of chromosome stability (HP:0003220)2.08933548
91Short humerus (HP:0005792)2.08470449
92Carpal bone hypoplasia (HP:0001498)2.07935463
93Aplasia/hypoplasia of the humerus (HP:0006507)2.07271481
94Osteomalacia (HP:0002749)2.04987631
95Cholecystitis (HP:0001082)2.04863590
96Abnormal gallbladder physiology (HP:0012438)2.04863590
97Poikiloderma (HP:0001029)2.04027077
98Optic nerve hypoplasia (HP:0000609)2.03494109
99Hypophosphatemic rickets (HP:0004912)2.00939462
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.2022256
101Aplasia/Hypoplasia of the uvula (HP:0010293)1.99710833
102Hypoplasia of the radius (HP:0002984)1.97948856
103Sloping forehead (HP:0000340)1.97117750
104Abdominal situs inversus (HP:0003363)1.96625980
105Abnormality of abdominal situs (HP:0011620)1.96625980
106Abnormality of the proximal phalanges of the hand (HP:0009834)1.96340267
107Aplasia/Hypoplasia of the tibia (HP:0005772)1.94602419
108Abnormality of femoral epiphyses (HP:0006499)1.94123797
109Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.94123797
110Abnormality of macular pigmentation (HP:0008002)1.94062709
111Bony spicule pigmentary retinopathy (HP:0007737)1.93733319
112Self-mutilation (HP:0000742)1.92136532
113Decreased activity of mitochondrial respiratory chain (HP:0008972)1.91842277
114Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.91842277
115Abnormality of the femoral head (HP:0003368)1.91755687
116Meckel diverticulum (HP:0002245)1.90764518
117Unsteady gait (HP:0002317)1.88105276
118Abnormal finger flexion creases (HP:0006143)1.86519835
119Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.85844903
120Impaired proprioception (HP:0010831)1.84903385
121Absent radius (HP:0003974)1.83699421
122Abnormality of DNA repair (HP:0003254)1.83658372
123Short thorax (HP:0010306)1.81172596
124Thoracolumbar scoliosis (HP:0002944)1.81143278
125Abnormality of the ileum (HP:0001549)1.80420504
126Renal Fanconi syndrome (HP:0001994)1.79695616
127Tubulointerstitial abnormality (HP:0001969)1.79671345
128Atrophy/Degeneration involving motor neurons (HP:0007373)1.78293870
129Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.76472536
130Aplasia/hypoplasia of the femur (HP:0005613)1.76121431
131Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74691520
132Ectopic kidney (HP:0000086)1.74565390
133Abnormality of the 2nd finger (HP:0004100)1.74459548
134Abnormality of the epiphyses of the hand (HP:0005924)1.73028297
135Lipid accumulation in hepatocytes (HP:0006561)1.72680304
136Abnormality of the duodenum (HP:0002246)1.72029952
137Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.72015664
138Aplasia involving forearm bones (HP:0009822)1.71831095
139Absent forearm bone (HP:0003953)1.71831095
140Abnormal protein glycosylation (HP:0012346)1.71802399
141Abnormal glycosylation (HP:0012345)1.71802399
142Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71802399
143Abnormal protein N-linked glycosylation (HP:0012347)1.71802399
144Abnormality of the renal collecting system (HP:0004742)1.71548414
145Abnormal rod and cone electroretinograms (HP:0008323)1.71255478
146Renal dysplasia (HP:0000110)1.70794037
147Postaxial foot polydactyly (HP:0001830)1.70456957
148Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.70177625
149Glycosuria (HP:0003076)1.69769721
150Abnormality of urine glucose concentration (HP:0011016)1.69769721
151Insulin-resistant diabetes mellitus (HP:0000831)1.67140241
152Heterotopia (HP:0002282)1.66890498
153Spontaneous abortion (HP:0005268)1.65646234
154Generalized aminoaciduria (HP:0002909)1.65127989
155Abnormality of the carotid arteries (HP:0005344)1.64962584
156Oculomotor apraxia (HP:0000657)1.63279884
157Prominent nose (HP:0000448)1.62905416
158Aplasia/Hypoplasia of the fibula (HP:0006492)1.61621125
159Hypoplastic iliac wings (HP:0002866)1.60165970
160Upper motor neuron abnormality (HP:0002127)1.59961429
161Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.59732877
162Absent epiphyses (HP:0010577)1.59408809
163Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.59408809
164Ridged nail (HP:0001807)1.59249763
165Aplasia/Hypoplasia of the earlobes (HP:0009906)1.58435540
166Papillary thyroid carcinoma (HP:0002895)1.57641501
167Facial cleft (HP:0002006)1.56472938

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK16.31256112
2PDK45.64579674
3PDK35.64579674
4MARK35.06213855
5PRKD34.26941177
6NEK23.53987255
7PDK23.48322352
8CDK123.06353056
9CDC72.89540849
10ICK2.85998154
11TTK2.69410439
12MYLK2.68799407
13PLK42.60422835
14PASK2.19671113
15BUB12.10103574
16CHEK21.94508604
17WEE11.89080729
18PBK1.85380384
19TESK21.62358108
20LATS11.59608455
21EIF2AK31.56062496
22PLK11.51978006
23STK381.50776721
24BRAF1.42029370
25PTK2B1.39384232
26MAP3K131.30820193
27ATR1.22352711
28PNCK1.18309165
29TLK11.14894906
30BMPR1B1.12982773
31DYRK31.12056902
32ACVR1B1.09459596
33AURKB1.08355704
34EEF2K1.02749719
35PKN11.00513674
36CHEK10.98609925
37WNK40.98312223
38VRK10.97871903
39EIF2AK10.93675608
40NEK10.92571157
41FRK0.91611712
42ZAK0.90721150
43MOS0.86225300
44NEK60.85734515
45TAOK30.84592602
46SRPK10.82645426
47ATM0.81243336
48CDK90.78720361
49AURKA0.78695448
50BRSK20.78337680
51PLK20.78022531
52STK160.76746719
53STK30.75410170
54MST1R0.74861479
55STK38L0.73588968
56CCNB10.73211462
57DYRK1B0.71607545
58CDK70.71371501
59STK40.69660628
60MTOR0.68178161
61MAP2K70.64257926
62EPHA20.60753020
63MST40.60130895
64CAMK1D0.59891617
65TIE10.58989881
66PRKG10.58343807
67TNIK0.57859451
68PRKCQ0.57650562
69TAOK10.56932327
70CDK20.55870813
71MAP3K80.55651357
72PIK3CA0.55528169
73STK100.54606306
74RAF10.54315620
75LATS20.53008554
76STK390.52798191
77PAK10.50694674
78TYRO30.50504575
79CDK140.50465440
80WNK30.49205524
81PAK40.49135274
82CDK10.48538491
83SGK2230.47736835
84SGK4940.47736835
85BRSK10.46421578
86OBSCN0.46372088
87BRD40.46119066
88ILK0.45700629
89PRKAA10.45616407
90PDK10.44920957
91CDK30.44616142
92RPS6KA50.44348567
93CSNK1G10.43400913
94MAP3K50.43388788
95PIM10.42830754
96KSR20.42539841
97CDK40.42450026
98CLK10.41543212
99MAP3K60.41193944
100PINK10.39322031
101MAPK150.39091003
102PRKG20.38048187
103CAMK10.37312960
104PAK20.36751921
105MAPKAPK30.36227625
106RPS6KB20.35712130
107ARAF0.34674878
108CAMKK10.33424950
109AKT20.32677887
110MAP3K90.31644756
111CDK50.31503479
112CAMK1G0.31450588
113CDK190.31229522
114DAPK30.30784575
115EGFR0.29865621
116RPS6KA10.29766686
117OXSR10.29634047
118RPS6KB10.29158014
119PLK30.28948655
120CSNK1A1L0.28725980
121CSNK1G30.27909477
122NUAK10.27224881
123RPS6KA40.26651850
124MAPK10.26544117
125ROCK10.26085676
126PRKACB0.25773608
127TRIM280.25338905
128MUSK0.24042222
129MELK0.23965791
130MET0.22638351
131CSNK2A10.21474810
132RPS6KA30.21470552
133KDR0.21466154
134MAPKAPK50.21307865
135DYRK20.21026102
136GSK3B0.20116259
137MAP2K20.20000397
138SCYL20.18428094
139WNK10.18128438
140STK110.17215241
141CSNK1E0.17129568
142MAPK140.13557822
143PDPK10.12892471
144CDK150.12403665
145CSNK2A20.10867726
146CDK180.10840047
147PRKDC0.10607459

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051305.17984158
2Gap junction_Homo sapiens_hsa045403.65826388
3DNA replication_Homo sapiens_hsa030303.54877295
4Basal transcription factors_Homo sapiens_hsa030223.49067563
5Fanconi anemia pathway_Homo sapiens_hsa034603.38993547
6* Systemic lupus erythematosus_Homo sapiens_hsa053222.99059931
7Homologous recombination_Homo sapiens_hsa034402.97126758
8Mismatch repair_Homo sapiens_hsa034302.79398013
9Linoleic acid metabolism_Homo sapiens_hsa005912.78034648
10Olfactory transduction_Homo sapiens_hsa047402.73083957
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.70991999
12Cell cycle_Homo sapiens_hsa041102.68921186
13RNA transport_Homo sapiens_hsa030132.63029477
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.27063339
15Vitamin B6 metabolism_Homo sapiens_hsa007502.25331752
16Sulfur metabolism_Homo sapiens_hsa009202.21318663
17Base excision repair_Homo sapiens_hsa034102.19769947
18Selenocompound metabolism_Homo sapiens_hsa004502.19427920
19Huntingtons disease_Homo sapiens_hsa050162.09100312
20Oocyte meiosis_Homo sapiens_hsa041142.01760254
21Apoptosis_Homo sapiens_hsa042101.96988558
22Nitrogen metabolism_Homo sapiens_hsa009101.88785271
23Pyrimidine metabolism_Homo sapiens_hsa002401.85402865
24Nucleotide excision repair_Homo sapiens_hsa034201.85153681
25Spliceosome_Homo sapiens_hsa030401.76140057
26Pentose phosphate pathway_Homo sapiens_hsa000301.70380615
27Phagosome_Homo sapiens_hsa041451.66231798
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.66071608
29RNA polymerase_Homo sapiens_hsa030201.63701836
30RNA degradation_Homo sapiens_hsa030181.62977050
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59343160
32* Alcoholism_Homo sapiens_hsa050341.58651270
33p53 signaling pathway_Homo sapiens_hsa041151.58589320
34Pyruvate metabolism_Homo sapiens_hsa006201.55963229
35Arginine biosynthesis_Homo sapiens_hsa002201.55326299
36Non-homologous end-joining_Homo sapiens_hsa034501.53656589
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.51602951
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.47720383
39Proteasome_Homo sapiens_hsa030501.45432781
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39401059
41mRNA surveillance pathway_Homo sapiens_hsa030151.36462863
42Butanoate metabolism_Homo sapiens_hsa006501.32393568
43Dorso-ventral axis formation_Homo sapiens_hsa043201.31729874
44Glucagon signaling pathway_Homo sapiens_hsa049221.28611728
45Ether lipid metabolism_Homo sapiens_hsa005651.28232152
46Fructose and mannose metabolism_Homo sapiens_hsa000511.26895073
47Glycerophospholipid metabolism_Homo sapiens_hsa005641.20405847
48Oxidative phosphorylation_Homo sapiens_hsa001901.19143112
49Parkinsons disease_Homo sapiens_hsa050121.18875144
50Purine metabolism_Homo sapiens_hsa002301.17449995
51Fat digestion and absorption_Homo sapiens_hsa049751.14663815
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.11158906
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09825339
54Cardiac muscle contraction_Homo sapiens_hsa042601.09011566
55Viral carcinogenesis_Homo sapiens_hsa052031.06950097
56Glutathione metabolism_Homo sapiens_hsa004801.04334893
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00399522
58Propanoate metabolism_Homo sapiens_hsa006401.00037407
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99511714
60Fatty acid biosynthesis_Homo sapiens_hsa000610.95926282
61Caffeine metabolism_Homo sapiens_hsa002320.95277435
62Arachidonic acid metabolism_Homo sapiens_hsa005900.91442488
63Glycerolipid metabolism_Homo sapiens_hsa005610.88007390
64Alzheimers disease_Homo sapiens_hsa050100.87487575
65Regulation of autophagy_Homo sapiens_hsa041400.86485581
66Taste transduction_Homo sapiens_hsa047420.85191367
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83964929
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81050808
69Carbon metabolism_Homo sapiens_hsa012000.80915506
70Antigen processing and presentation_Homo sapiens_hsa046120.77829742
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76496786
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76295257
73Fatty acid elongation_Homo sapiens_hsa000620.74088911
74Folate biosynthesis_Homo sapiens_hsa007900.72302724
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72131788
76Sulfur relay system_Homo sapiens_hsa041220.70400520
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65851157
78Hedgehog signaling pathway_Homo sapiens_hsa043400.59671541
79One carbon pool by folate_Homo sapiens_hsa006700.58588781
80Tryptophan metabolism_Homo sapiens_hsa003800.57649113
81Phenylalanine metabolism_Homo sapiens_hsa003600.53747161
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53701018
83Epstein-Barr virus infection_Homo sapiens_hsa051690.53536711
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53305947
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.52243200
86Mineral absorption_Homo sapiens_hsa049780.51671299
87Ribosome_Homo sapiens_hsa030100.50893369
88Metabolic pathways_Homo sapiens_hsa011000.48062995
89Retinol metabolism_Homo sapiens_hsa008300.46641653
90Biosynthesis of amino acids_Homo sapiens_hsa012300.45103161
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.42740880
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41930161
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.41439099
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41175264
95HTLV-I infection_Homo sapiens_hsa051660.40427927
96Fatty acid degradation_Homo sapiens_hsa000710.40219537
97Tyrosine metabolism_Homo sapiens_hsa003500.39644270
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39411924
99Notch signaling pathway_Homo sapiens_hsa043300.39164117
100beta-Alanine metabolism_Homo sapiens_hsa004100.38818686
101Arginine and proline metabolism_Homo sapiens_hsa003300.38520117
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37348232
103Herpes simplex infection_Homo sapiens_hsa051680.36880577
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35518662
105Fatty acid metabolism_Homo sapiens_hsa012120.33803228
106Circadian rhythm_Homo sapiens_hsa047100.32215933
107Synaptic vesicle cycle_Homo sapiens_hsa047210.31653725
108Amphetamine addiction_Homo sapiens_hsa050310.30933479
109Protein digestion and absorption_Homo sapiens_hsa049740.29397554
110Phototransduction_Homo sapiens_hsa047440.29055590
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28462956
112Ovarian steroidogenesis_Homo sapiens_hsa049130.26933839
113Nicotine addiction_Homo sapiens_hsa050330.26131724
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25772723
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25764437
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.25633515
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25510707
118PPAR signaling pathway_Homo sapiens_hsa033200.25428772
119Salmonella infection_Homo sapiens_hsa051320.25045271
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.23716824
121MicroRNAs in cancer_Homo sapiens_hsa052060.23643603
122AMPK signaling pathway_Homo sapiens_hsa041520.22571321
123Calcium signaling pathway_Homo sapiens_hsa040200.21972279
124Bile secretion_Homo sapiens_hsa049760.21403674
125Wnt signaling pathway_Homo sapiens_hsa043100.19524082
126Chemical carcinogenesis_Homo sapiens_hsa052040.19462386
127TGF-beta signaling pathway_Homo sapiens_hsa043500.19119321
128Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18925709
129Basal cell carcinoma_Homo sapiens_hsa052170.17890013
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17794785
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17540034
132Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16986348
133mTOR signaling pathway_Homo sapiens_hsa041500.16379333
134Lysine degradation_Homo sapiens_hsa003100.15955995
135N-Glycan biosynthesis_Homo sapiens_hsa005100.15579704
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15142746
137Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.14487986
138ABC transporters_Homo sapiens_hsa020100.14467909
139Thyroid cancer_Homo sapiens_hsa052160.14285789
140HIF-1 signaling pathway_Homo sapiens_hsa040660.13027755
141Glycosaminoglycan degradation_Homo sapiens_hsa005310.12614087
142Legionellosis_Homo sapiens_hsa051340.08733025

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