HIST1H2AD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mucosal immune response (GO:0002385)8.99142708
2organ or tissue specific immune response (GO:0002251)8.15352513
3DNA replication-dependent nucleosome organization (GO:0034723)7.29971162
4DNA replication-dependent nucleosome assembly (GO:0006335)7.29971162
5chromatin assembly (GO:0031497)5.96584932
6mitotic chromosome condensation (GO:0007076)5.69561080
7viral transcription (GO:0019083)5.60778877
8translational termination (GO:0006415)5.47885217
9DNA unwinding involved in DNA replication (GO:0006268)5.42854377
10kinetochore organization (GO:0051383)5.35247575
11protein localization to kinetochore (GO:0034501)5.35196851
12regulation of histone H3-K9 methylation (GO:0051570)5.22798815
13nucleosome assembly (GO:0006334)5.16677235
14sister chromatid segregation (GO:0000819)5.10338758
15mitotic sister chromatid segregation (GO:0000070)5.07860108
16ribosomal small subunit assembly (GO:0000028)5.05031192
17chromatin assembly or disassembly (GO:0006333)4.98377709
18nuclear pore organization (GO:0006999)4.90536332
19chromatin remodeling at centromere (GO:0031055)4.83520401
20CENP-A containing nucleosome assembly (GO:0034080)4.79420564
21nuclear pore complex assembly (GO:0051292)4.78930250
22maturation of SSU-rRNA (GO:0030490)4.76247157
23translational elongation (GO:0006414)4.74507129
24ribosomal large subunit biogenesis (GO:0042273)4.74253948
25ribosomal small subunit biogenesis (GO:0042274)4.72084248
26folic acid-containing compound biosynthetic process (GO:0009396)4.71997522
27protein localization to chromosome, centromeric region (GO:0071459)4.69141480
28meiotic chromosome segregation (GO:0045132)4.68531266
29nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.50756642
30DNA replication initiation (GO:0006270)4.47154421
31protein-DNA complex assembly (GO:0065004)4.46784336
32nucleosome organization (GO:0034728)4.45644810
33DNA strand elongation involved in DNA replication (GO:0006271)4.36406507
34cellular protein complex disassembly (GO:0043624)4.35478627
35translational initiation (GO:0006413)4.34977358
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.33397017
37regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.25462786
38protein targeting to ER (GO:0045047)4.23369622
39cotranslational protein targeting to membrane (GO:0006613)4.22899043
40telomere maintenance via semi-conservative replication (GO:0032201)4.16503328
41mitotic metaphase plate congression (GO:0007080)4.15753748
42viral life cycle (GO:0019058)4.11721022
43DNA strand elongation (GO:0022616)4.11603401
44DNA replication-independent nucleosome assembly (GO:0006336)4.07001284
45DNA replication-independent nucleosome organization (GO:0034724)4.07001284
46establishment of protein localization to endoplasmic reticulum (GO:0072599)4.04973900
47mitotic recombination (GO:0006312)4.00806413
48protein complex disassembly (GO:0043241)4.00554642
49protein-DNA complex subunit organization (GO:0071824)3.97852428
50DNA topological change (GO:0006265)3.93230024
51telomere maintenance via recombination (GO:0000722)3.88533467
52protein localization to endoplasmic reticulum (GO:0070972)3.88171121
53metaphase plate congression (GO:0051310)3.85416425
54mitotic sister chromatid cohesion (GO:0007064)3.83319989
55DNA duplex unwinding (GO:0032508)3.81184675
56IMP biosynthetic process (GO:0006188)3.81002732
57histone exchange (GO:0043486)3.80481130
58antibacterial humoral response (GO:0019731)3.78207061
59DNA geometric change (GO:0032392)3.77409175
60macromolecular complex disassembly (GO:0032984)3.76597383
61regulation of gene silencing by RNA (GO:0060966)3.74632005
62regulation of posttranscriptional gene silencing (GO:0060147)3.74632005
63regulation of gene silencing by miRNA (GO:0060964)3.74632005
64regulation of sister chromatid cohesion (GO:0007063)3.74052298
65chromosome condensation (GO:0030261)3.72137095
66DNA replication checkpoint (GO:0000076)3.69678022
67mitotic nuclear envelope disassembly (GO:0007077)3.69138622
68regulation of megakaryocyte differentiation (GO:0045652)3.68680814
69pore complex assembly (GO:0046931)3.66825087
70regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.64937719
71viral mRNA export from host cell nucleus (GO:0046784)3.60912593
72defense response to Gram-positive bacterium (GO:0050830)3.57325918
73regulation of translational fidelity (GO:0006450)3.56660267
74kinetochore assembly (GO:0051382)3.55026389
75antimicrobial humoral response (GO:0019730)3.53398294
76innate immune response in mucosa (GO:0002227)3.50239056
77regulation of centrosome cycle (GO:0046605)3.46684193
78membrane disassembly (GO:0030397)3.45629376
79nuclear envelope disassembly (GO:0051081)3.45629376
80regulation of spindle organization (GO:0090224)3.45321695
81telomere maintenance via telomere lengthening (GO:0010833)3.42088507
82attachment of spindle microtubules to kinetochore (GO:0008608)3.41482558
83ribonucleoprotein complex biogenesis (GO:0022613)3.40738119
84nuclear-transcribed mRNA catabolic process (GO:0000956)3.39958711
85IMP metabolic process (GO:0046040)3.39078347
86DNA conformation change (GO:0071103)3.36915659
87nucleotide-excision repair, DNA gap filling (GO:0006297)3.36461958
88regulation of mammary gland epithelial cell proliferation (GO:0033599)3.35178520
89nucleobase biosynthetic process (GO:0046112)3.34946133
90somatic diversification of immune receptors via somatic mutation (GO:0002566)3.32085233
91somatic hypermutation of immunoglobulin genes (GO:0016446)3.32085233
92regulation of mitotic spindle organization (GO:0060236)3.31030528
93protein K6-linked ubiquitination (GO:0085020)3.30932023
94telomere maintenance (GO:0000723)3.27437511
95establishment of chromosome localization (GO:0051303)3.26805962
96telomere organization (GO:0032200)3.25811881
97V(D)J recombination (GO:0033151)3.23824845
98DNA packaging (GO:0006323)3.23014292
99mRNA catabolic process (GO:0006402)3.22365288
100regulation of gene silencing (GO:0060968)3.22045475
101regulation of DNA endoreduplication (GO:0032875)3.20874287
102negative regulation of histone methylation (GO:0031061)3.18920180
103DNA synthesis involved in DNA repair (GO:0000731)3.18801002
104regulation of centriole replication (GO:0046599)3.18639008
105chromosome segregation (GO:0007059)3.18563239
106regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.18435093
107RNA catabolic process (GO:0006401)3.17684547
108negative regulation of chromosome segregation (GO:0051985)3.16923259
109mitochondrial DNA metabolic process (GO:0032042)3.16391112
110protein localization to chromosome (GO:0034502)3.15468077
111double-strand break repair via nonhomologous end joining (GO:0006303)3.15358237
112non-recombinational repair (GO:0000726)3.15358237
113ATP-dependent chromatin remodeling (GO:0043044)3.13938082
114negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.10769972
115regulation of chromosome segregation (GO:0051983)3.10402740
116positive regulation of chromosome segregation (GO:0051984)3.03606787
117rRNA transcription (GO:0009303)3.03382874
118protein complex localization (GO:0031503)3.02724084
119regulation of sister chromatid segregation (GO:0033045)3.02633325
120regulation of mitotic sister chromatid separation (GO:0010965)3.02633325
121regulation of mitotic sister chromatid segregation (GO:0033047)3.02633325
122peptidyl-lysine dimethylation (GO:0018027)3.02023033
123regulation of centrosome duplication (GO:0010824)3.00657295
124regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.99332125
125regulation of mitotic metaphase/anaphase transition (GO:0030071)2.99332125
126negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.99075113
127negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.99075113
128negative regulation of mitotic sister chromatid segregation (GO:0033048)2.99075113
129negative regulation of mitotic sister chromatid separation (GO:2000816)2.99075113
130negative regulation of sister chromatid segregation (GO:0033046)2.99075113
131cellular protein complex localization (GO:0034629)2.98605037
132mitotic spindle assembly checkpoint (GO:0007094)2.97829426
133spindle assembly checkpoint (GO:0071173)2.97408124
134spindle checkpoint (GO:0031577)2.92283721
135nucleobase-containing small molecule interconversion (GO:0015949)2.85108311
136mature B cell differentiation involved in immune response (GO:0002313)2.84317213
137positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.84070682
138positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.84070682
139positive regulation of mitotic sister chromatid separation (GO:1901970)2.84070682
140mitotic spindle checkpoint (GO:0071174)2.80580420
141negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.80271543
142translesion synthesis (GO:0019985)2.80136686
143somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.78753123
144somatic cell DNA recombination (GO:0016444)2.78753123
145regulation of spindle checkpoint (GO:0090231)2.78700921

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.63103673
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.89276513
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.55540679
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.21016316
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.10202725
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.87874197
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.76753044
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.74247116
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.71450946
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.40823771
11* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.39419477
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31505876
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26267177
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.25473984
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.01098446
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00918895
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse12.3599089
18AR_21909140_ChIP-Seq_LNCAP_Human1.91706685
19MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78612358
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77639753
21VDR_23849224_ChIP-Seq_CD4+_Human1.70044400
22* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.67765550
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.67433035
24SOX2_16153702_ChIP-ChIP_HESCs_Human1.65178181
25XRN2_22483619_ChIP-Seq_HELA_Human1.64892962
26* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63942155
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.59181497
28SOX2_18555785_ChIP-Seq_MESCs_Mouse1.58147213
29KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.54075714
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52457483
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50295350
32IRF1_19129219_ChIP-ChIP_H3396_Human1.49851335
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47831447
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47794005
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44897513
36ELK1_19687146_ChIP-ChIP_HELA_Human1.44473341
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.43326609
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42218842
39SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.42186647
40POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41801712
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41039712
42GATA1_22025678_ChIP-Seq_K562_Human1.40740666
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39717271
44FOXP3_21729870_ChIP-Seq_TREG_Human1.39186979
45* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34571924
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32375853
47HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30730185
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.30281841
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28147341
50* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27956568
51* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24892218
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24263333
53TTF2_22483619_ChIP-Seq_HELA_Human1.24127937
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22611435
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20368327
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19579132
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19405279
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18914320
59DCP1A_22483619_ChIP-Seq_HELA_Human1.14459338
60MYC_22102868_ChIP-Seq_BL_Human1.11996278
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08964755
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08602951
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08248574
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06213448
65TCF3_18692474_ChIP-Seq_MESCs_Mouse1.06168092
66NANOG_16153702_ChIP-ChIP_HESCs_Human1.03969242
67JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02674242
68* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.02596446
69MYC_18940864_ChIP-ChIP_HL60_Human1.00657023
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99507204
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99473522
72STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97608333
73VDR_21846776_ChIP-Seq_THP-1_Human0.96247716
74PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95899539
75* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95580581
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95184004
77NOTCH1_21737748_ChIP-Seq_TLL_Human0.94287409
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.93335793
79ETS1_22383799_ChIP-Seq_G1ME_Mouse0.92984095
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92319316
81RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91432796
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90967898
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90753131
84SALL1_21062744_ChIP-ChIP_HESCs_Human0.90432722
85ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89141992
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88587070
87CIITA_25753668_ChIP-Seq_RAJI_Human0.85361443
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.84959052
89KDM5A_27292631_Chip-Seq_BREAST_Human0.84211771
90* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.82738619
91GABP_19822575_ChIP-Seq_HepG2_Human0.81430380
92TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80516032
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.80455484
94TP63_19390658_ChIP-ChIP_HaCaT_Human0.79403417
95PKCTHETA_26484144_Chip-Seq_BREAST_Human0.79372627
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79091171
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.78211529
98KLF4_18555785_ChIP-Seq_MESCs_Mouse0.75763017
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.75321705
100MAF_26560356_Chip-Seq_TH1_Human0.73572058
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.73420158
102TP63_17297297_ChIP-ChIP_HaCaT_Human0.73000760
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.71494183
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71157424
105ZNF263_19887448_ChIP-Seq_K562_Human0.70378759
106E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.70129261
107ELF1_17652178_ChIP-ChIP_JURKAT_Human0.68054723
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.67715574
109BRD4_27068464_Chip-Seq_AML-cells_Mouse0.67714879
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.67594283
111FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.67589186
112SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.67466822
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.67302619
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.64785425
115ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.62263641

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.92990289
2MP0010094_abnormal_chromosome_stability4.71059415
3MP0003111_abnormal_nucleus_morphology4.64857561
4MP0004957_abnormal_blastocyst_morpholog4.29066920
5MP0003077_abnormal_cell_cycle3.95779418
6MP0008057_abnormal_DNA_replication3.32793986
7MP0002009_preneoplasia3.29812384
8MP0010307_abnormal_tumor_latency3.07363486
9MP0008058_abnormal_DNA_repair2.82368492
10MP0003123_paternal_imprinting2.79523746
11MP0010352_gastrointestinal_tract_polyps2.77814502
12MP0008932_abnormal_embryonic_tissue2.74493712
13MP0008007_abnormal_cellular_replicative2.56495563
14MP0000350_abnormal_cell_proliferation2.44480099
15MP0001730_embryonic_growth_arrest2.43483068
16MP0000490_abnormal_crypts_of2.08468121
17MP0003705_abnormal_hypodermis_morpholog2.05856177
18MP0005076_abnormal_cell_differentiation2.03815236
19MP0009697_abnormal_copulation1.94413499
20MP0001697_abnormal_embryo_size1.90356117
21MP0001661_extended_life_span1.87497690
22MP0008877_abnormal_DNA_methylation1.83139309
23MP0004197_abnormal_fetal_growth/weight/1.82010755
24MP0003121_genomic_imprinting1.78542649
25MP0001672_abnormal_embryogenesis/_devel1.77988847
26MP0005380_embryogenesis_phenotype1.77988847
27MP0002396_abnormal_hematopoietic_system1.77225684
28MP0002085_abnormal_embryonic_tissue1.73548275
29MP0002084_abnormal_developmental_patter1.70977885
30MP0002086_abnormal_extraembryonic_tissu1.69238601
31MP0000685_abnormal_immune_system1.65718556
32MP0005645_abnormal_hypothalamus_physiol1.62538871
33MP0002080_prenatal_lethality1.61766512
34MP0004808_abnormal_hematopoietic_stem1.60012822
35MP0006035_abnormal_mitochondrial_morpho1.56893361
36MP0010030_abnormal_orbit_morphology1.51685723
37MP0003984_embryonic_growth_retardation1.49967432
38MP0002088_abnormal_embryonic_growth/wei1.48443203
39MP0002019_abnormal_tumor_incidence1.48114023
40MP0000537_abnormal_urethra_morphology1.47844835
41MP0000703_abnormal_thymus_morphology1.44692987
42MP0003890_abnormal_embryonic-extraembry1.42595535
43MP0000313_abnormal_cell_death1.42269034
44MP0003300_gastrointestinal_ulcer1.35108273
45MP0003786_premature_aging1.28366895
46MP0009379_abnormal_foot_pigmentation1.27395836
47MP0003567_abnormal_fetal_cardiomyocyte1.25421568
48MP0003806_abnormal_nucleotide_metabolis1.25417753
49MP0001915_intracranial_hemorrhage1.24366214
50MP0001293_anophthalmia1.21360933
51MP0001727_abnormal_embryo_implantation1.18520295
52MP0002111_abnormal_tail_morphology1.17702634
53MP0009333_abnormal_splenocyte_physiolog1.17334651
54MP0002254_reproductive_system_inflammat1.16750865
55MP0003787_abnormal_imprinting1.16212260
56MP0003763_abnormal_thymus_physiology1.14276828
57MP0005220_abnormal_exocrine_pancreas1.14166328
58MP0009672_abnormal_birth_weight1.11563993
59MP0002163_abnormal_gland_morphology1.11208141
60MP0002398_abnormal_bone_marrow1.11198071
61MP0002722_abnormal_immune_system1.09754685
62MP0009703_decreased_birth_body1.09682841
63MP0003937_abnormal_limbs/digits/tail_de1.08240362
64MP0002877_abnormal_melanocyte_morpholog1.06840685
65MP0009053_abnormal_anal_canal1.04416510
66MP0010234_abnormal_vibrissa_follicle1.04311000
67MP0003718_maternal_effect1.00362422
68MP0003656_abnormal_erythrocyte_physiolo0.99670315
69MP0003941_abnormal_skin_development0.97272658
70MP0005623_abnormal_meninges_morphology0.96359619
71MP0000858_altered_metastatic_potential0.94210172
72MP0001835_abnormal_antigen_presentation0.94148828
73MP0002160_abnormal_reproductive_system0.92426809
74MP0001849_ear_inflammation0.91329177
75MP0000689_abnormal_spleen_morphology0.90559174
76MP0005023_abnormal_wound_healing0.90272288
77MP0003448_altered_tumor_morphology0.89817679
78MP0002092_abnormal_eye_morphology0.89139883
79MP0003119_abnormal_digestive_system0.89091603
80MP0004233_abnormal_muscle_weight0.88069953
81MP0000428_abnormal_craniofacial_morphol0.85992923
82MP0000733_abnormal_muscle_development0.85174241
83MP0002697_abnormal_eye_size0.83699246
84MP0003283_abnormal_digestive_organ0.82917583
85MP0002138_abnormal_hepatobiliary_system0.81401796
86MP0003566_abnormal_cell_adhesion0.81379732
87MP0002429_abnormal_blood_cell0.80574623
88MP0001873_stomach_inflammation0.80130426
89MP0001986_abnormal_taste_sensitivity0.79910134
90MP0000477_abnormal_intestine_morphology0.79530413
91MP0003315_abnormal_perineum_morphology0.79149344
92MP0000569_abnormal_digit_pigmentation0.78402656
93MP0002006_tumorigenesis0.77662935
94MP0004381_abnormal_hair_follicle0.77170744
95MP0010678_abnormal_skin_adnexa0.76516451
96MP0005384_cellular_phenotype0.75402344
97MP0005451_abnormal_body_composition0.74927095
98MP0008770_decreased_survivor_rate0.73512961
99MP0000432_abnormal_head_morphology0.72984058
100MP0001286_abnormal_eye_development0.72918895
101MP0005621_abnormal_cell_physiology0.72091870
102MP0006054_spinal_hemorrhage0.70623151
103MP0005310_abnormal_salivary_gland0.70496093
104MP0000015_abnormal_ear_pigmentation0.69740758
105MP0001346_abnormal_lacrimal_gland0.69500978
106MP0001545_abnormal_hematopoietic_system0.68525636
107MP0005397_hematopoietic_system_phenotyp0.68525636
108MP0008995_early_reproductive_senescence0.67742674
109MP0000358_abnormal_cell_content/0.67298843
110MP0004133_heterotaxia0.66944738
111MP0001145_abnormal_male_reproductive0.66736299
112MP0000465_gastrointestinal_hemorrhage0.66629868
113MP0002060_abnormal_skin_morphology0.66475063
114MP0002166_altered_tumor_susceptibility0.66185562
115MP0001216_abnormal_epidermal_layer0.65983972
116MP0001191_abnormal_skin_condition0.65867852
117MP0006072_abnormal_retinal_apoptosis0.65866995
118MP0005501_abnormal_skin_physiology0.65847032
119MP0000716_abnormal_immune_system0.65530123
120MP0009278_abnormal_bone_marrow0.64981589
121MP0003221_abnormal_cardiomyocyte_apopto0.64939062
122MP0001929_abnormal_gametogenesis0.62972130
123MP0002925_abnormal_cardiovascular_devel0.62911009
124MP0003861_abnormal_nervous_system0.62620137
125MP0004947_skin_inflammation0.61315036
126MP0002210_abnormal_sex_determination0.60719063
127MP0002098_abnormal_vibrissa_morphology0.60431400
128MP0003699_abnormal_female_reproductive0.60313657
129MP0008260_abnormal_autophagy0.60124107
130MP0003453_abnormal_keratinocyte_physiol0.59860198
131MP0001800_abnormal_humoral_immune0.58600905
132MP0004185_abnormal_adipocyte_glucose0.55940825
133MP0003935_abnormal_craniofacial_develop0.54399121
134MP0005671_abnormal_response_to0.54279644
135MP0000653_abnormal_sex_gland0.53985967
136MP0005083_abnormal_biliary_tract0.51800264
137MP0002420_abnormal_adaptive_immunity0.50409866

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.28055853
2IgA deficiency (HP:0002720)4.96321938
3Abnormality of cells of the erythroid lineage (HP:0012130)4.45584636
4Colitis (HP:0002583)4.37691951
5Macrocytic anemia (HP:0001972)4.16058305
6Abnormal number of erythroid precursors (HP:0012131)3.86609142
7Chromsome breakage (HP:0040012)3.71256481
8Pallor (HP:0000980)3.60630030
9Colon cancer (HP:0003003)3.54789020
10Volvulus (HP:0002580)3.41915070
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.17169279
12Abnormality of chromosome stability (HP:0003220)3.16698010
13Birth length less than 3rd percentile (HP:0003561)3.12825386
14Impulsivity (HP:0100710)3.10007915
15Microvesicular hepatic steatosis (HP:0001414)3.07421689
16Ependymoma (HP:0002888)3.07388183
17Proximal placement of thumb (HP:0009623)3.02611982
18Selective tooth agenesis (HP:0001592)2.97676520
19B lymphocytopenia (HP:0010976)2.96141438
20Abnormality of the carotid arteries (HP:0005344)2.95627717
21Deviation of the thumb (HP:0009603)2.92707355
22Rhabdomyosarcoma (HP:0002859)2.88940364
23Basal cell carcinoma (HP:0002671)2.85446201
24Abnormality of the labia minora (HP:0012880)2.83880544
25Abnormality of reticulocytes (HP:0004312)2.82274177
26Medulloblastoma (HP:0002885)2.81922383
27Cellulitis (HP:0100658)2.68769451
28Biliary tract neoplasm (HP:0100574)2.64917097
29Increased nuchal translucency (HP:0010880)2.63491151
30Thyroiditis (HP:0100646)2.61968086
31Abnormal hemoglobin (HP:0011902)2.61650152
32Clubbing of toes (HP:0100760)2.59752948
33Inflammation of the large intestine (HP:0002037)2.59063791
34Agnosia (HP:0010524)2.57653016
35Meckel diverticulum (HP:0002245)2.55580507
36Progressive external ophthalmoplegia (HP:0000590)2.54850990
37Poikilocytosis (HP:0004447)2.50553790
38Embryonal renal neoplasm (HP:0011794)2.48762975
39Abnormality of the preputium (HP:0100587)2.47516445
40High pitched voice (HP:0001620)2.46651237
41Hypochromic microcytic anemia (HP:0004840)2.45943273
4211 pairs of ribs (HP:0000878)2.43321369
43Abnormality of the ileum (HP:0001549)2.42498119
44Patellar aplasia (HP:0006443)2.42438032
45Gastrointestinal inflammation (HP:0004386)2.42317483
46Aplasia/Hypoplasia of the patella (HP:0006498)2.41465405
47Myelodysplasia (HP:0002863)2.41357947
48Absent thumb (HP:0009777)2.40485740
49Hypochromic anemia (HP:0001931)2.38930053
50Aplasia/Hypoplasia of the sacrum (HP:0008517)2.38315158
51Absent radius (HP:0003974)2.37326819
52Abnormality of the astrocytes (HP:0100707)2.37174708
53Astrocytoma (HP:0009592)2.37174708
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.34876368
55Ectopic kidney (HP:0000086)2.31388782
56Abnormality of B cell number (HP:0010975)2.29794302
57Small intestinal stenosis (HP:0012848)2.27841773
58Duodenal stenosis (HP:0100867)2.27841773
59Cafe-au-lait spot (HP:0000957)2.27806029
60Abnormality of DNA repair (HP:0003254)2.26353504
61Abnormal number of incisors (HP:0011064)2.25488992
62Gastrointestinal stroma tumor (HP:0100723)2.23763713
63Acute lymphatic leukemia (HP:0006721)2.23196284
64Horseshoe kidney (HP:0000085)2.22646505
65Missing ribs (HP:0000921)2.22567371
66Sandal gap (HP:0001852)2.20363954
67Atresia of the external auditory canal (HP:0000413)2.20294492
68Prominent nose (HP:0000448)2.19885377
69Amaurosis fugax (HP:0100576)2.18724009
70Insomnia (HP:0100785)2.18150293
71Hyperacusis (HP:0010780)2.18001631
72Absent forearm bone (HP:0003953)2.17513523
73Aplasia involving forearm bones (HP:0009822)2.17513523
74Squamous cell carcinoma (HP:0002860)2.17353669
75Abnormality of abdominal situs (HP:0011620)2.16898899
76Abdominal situs inversus (HP:0003363)2.16898899
77Rib fusion (HP:0000902)2.15009423
78Agammaglobulinemia (HP:0004432)2.14853592
79Lymphoma (HP:0002665)2.14781008
80Neoplasm of the pancreas (HP:0002894)2.14016638
81Neoplasm of the oral cavity (HP:0100649)2.11575788
82Recurrent viral infections (HP:0004429)2.09899278
83Abnormality of the distal phalanx of the thumb (HP:0009617)2.09617023
84Sloping forehead (HP:0000340)2.09374381
85Oral leukoplakia (HP:0002745)2.09128980
86Recurrent sinusitis (HP:0011108)2.07227695
87Aplastic anemia (HP:0001915)2.06038172
88Facial hemangioma (HP:0000329)2.05244735
89Dry hair (HP:0011359)2.04945482
90IgM deficiency (HP:0002850)2.04707153
91Poikiloderma (HP:0001029)2.03955002
92Progressive muscle weakness (HP:0003323)2.03901297
93Glioma (HP:0009733)2.03385851
94Abnormality of the parietal bone (HP:0002696)2.02384852
95Abnormality of the renal collecting system (HP:0004742)2.01009996
96Neoplasm of the colon (HP:0100273)2.00466522
97Abnormality of the heme biosynthetic pathway (HP:0010472)1.99930583
98Gastrointestinal carcinoma (HP:0002672)1.99431375
99Malignant gastrointestinal tract tumors (HP:0006749)1.99431375
100Down-sloping shoulders (HP:0200021)1.99289088
101Thrombocytosis (HP:0001894)1.98200152
102Breast hypoplasia (HP:0003187)1.98078485
103Neoplasm of striated muscle (HP:0009728)1.95640672
104Acanthocytosis (HP:0001927)1.95412971
105Premature graying of hair (HP:0002216)1.94802263
106Abnormality of the duodenum (HP:0002246)1.94589062
107Renovascular hypertension (HP:0100817)1.94025212
108Abnormal lung lobation (HP:0002101)1.92819242
109Viral hepatitis (HP:0006562)1.92788158
110Prostate neoplasm (HP:0100787)1.92157618
111Ridged nail (HP:0001807)1.91373001
112Leiomyosarcoma (HP:0100243)1.91310468
113Uterine leiomyosarcoma (HP:0002891)1.91310468
114Spinal cord lesions (HP:0100561)1.91020479
115Syringomyelia (HP:0003396)1.91020479
116Arteriovenous malformation (HP:0100026)1.90831007
117Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.90311956
118Short thumb (HP:0009778)1.89801030
119Abnormality of the fingertips (HP:0001211)1.89074880
120Intestinal polyposis (HP:0200008)1.88215025
121Aplasia/Hypoplasia of the sternum (HP:0006714)1.88178697
122Entropion (HP:0000621)1.86839867
123Bone marrow hypocellularity (HP:0005528)1.86026588
124Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.85581062
125Short 4th metacarpal (HP:0010044)1.85581062
126Interstitial pulmonary disease (HP:0006530)1.84623423
127Stenosis of the external auditory canal (HP:0000402)1.84355552
128Abnormality of cells of the lymphoid lineage (HP:0012140)1.84238668
129Leukopenia (HP:0001882)1.84177682
130Abnormality of pyrimidine metabolism (HP:0004353)1.84002699
131Lymphopenia (HP:0001888)1.83712731
132Spastic diplegia (HP:0001264)1.83703296
133Deep philtrum (HP:0002002)1.83455805
134Hypergonadotropic hypogonadism (HP:0000815)1.81807821
135Erythema (HP:0010783)1.81049191
136Intestinal polyp (HP:0005266)1.80903277
137Degeneration of anterior horn cells (HP:0002398)1.79631426
138Abnormality of the anterior horn cell (HP:0006802)1.79631426
139Asplenia (HP:0001746)1.78359080
140Ankyloglossia (HP:0010296)1.78243252
141Ureteral duplication (HP:0000073)1.77893838
142Triphalangeal thumb (HP:0001199)1.77381919
143Nephroblastoma (Wilms tumor) (HP:0002667)1.77338364
144Chronic diarrhea (HP:0002028)1.77306788
145Duplicated collecting system (HP:0000081)1.76987772
146Hypoplasia of the pons (HP:0012110)1.76611050
147Tracheoesophageal fistula (HP:0002575)1.76055231
148Cerebral hypomyelination (HP:0006808)1.75809895
149Orthostatic hypotension (HP:0001278)1.74470593
150Cortical dysplasia (HP:0002539)1.74134884
151Hepatitis (HP:0012115)1.73688129
152Abnormality of cochlea (HP:0000375)1.73443885
153Short middle phalanx of the 5th finger (HP:0004220)1.73094157
154Ovarian neoplasm (HP:0100615)1.72980864
155Ankle contracture (HP:0006466)1.71514116
156Combined immunodeficiency (HP:0005387)1.71392825
157Subacute progressive viral hepatitis (HP:0006572)1.71354419

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.22120421
2ZAK4.70692619
3CDC74.25823647
4VRK13.22355136
5NEK22.55473415
6RPS6KA52.39457197
7BUB12.37230982
8STK42.25360853
9WEE12.18217523
10SCYL22.06541172
11SRPK12.00178752
12AURKB1.98149762
13RPS6KB21.65220610
14MAP3K101.64123668
15MAP3K81.63028558
16CDK121.61191247
17PIM11.58303210
18EIF2AK11.58269672
19PLK11.54146793
20EEF2K1.52377080
21NME21.49976090
22TTK1.47032910
23NEK11.43519914
24EPHA21.42867774
25CHEK21.40799949
26AURKA1.38245567
27PASK1.35195645
28DAPK31.25947192
29ATR1.24312033
30STK101.24265489
31SMG11.21930668
32CDK41.18864497
33CDK81.16698750
34DYRK31.10686291
35PKN21.06993300
36TRIB30.99884016
37CDK90.97466551
38PLK30.96868828
39EIF2AK30.94961458
40ALK0.92403580
41CHEK10.92125013
42FLT30.91475784
43CDK70.89540575
44MKNK20.88726205
45BRSK20.83960082
46CCNB10.82741869
47MKNK10.82355727
48EIF2AK20.81577036
49MELK0.81149205
50RPS6KA40.81025793
51ATM0.79966905
52TAF10.79124263
53TSSK60.77444924
54CDK20.75935695
55CDK60.75440529
56BRAF0.71087278
57PRPF4B0.66607061
58LRRK20.66430990
59TTN0.63459145
60TESK20.61803604
61ACVR1B0.59426250
62BTK0.57916739
63PLK40.57006563
64PKN10.53173843
65PRKAA10.52244513
66CDK10.52116524
67PBK0.49481994
68PIM20.48524245
69MAPK110.48337008
70ICK0.48101705
71GRK60.47957679
72CSNK2A20.46195498
73IRAK30.45701805
74BMPR1B0.44686882
75PAK40.41897218
76AKT20.41799308
77PAK10.41569639
78BRD40.41295831
79CAMK40.38917909
80STK160.38550475
81IRAK40.36782349
82PAK20.36411895
83FGFR40.36334698
84BRSK10.36297329
85FGR0.35498301
86ILK0.34853402
87CSNK1D0.34545331
88CSNK1E0.33484737
89ITK0.32991797
90PRKDC0.32261988
91TGFBR10.30451168
92PDGFRA0.30061056
93CSNK1G30.29014387
94BLK0.28868653
95RAF10.28800050
96CSNK1A1L0.28714142
97RIPK10.28501406
98MTOR0.28113839
99CSNK1G10.26153359
100CSNK2A10.25915942
101JAK20.25614463
102AKT10.24339318
103MAPK140.23871772
104RPS6KB10.22908249
105CAMK1D0.22893098
106DYRK1B0.22887552
107NME10.22666309
108PRKCQ0.22463640
109CAMKK20.21698826
110MAP3K30.20340082
111SYK0.20063578
112TEC0.19670324
113FGFR30.19259414
114PRKCI0.19154350
115MAP3K110.18826482
116NEK90.18441949
117CLK10.18375485
118MAP3K40.18013556
119KDR0.17469326
120MAP3K90.17213936
121RPS6KA10.16851270
122IRAK20.16627172
123MST1R0.16353521
124BMPR20.16065119
125NEK60.15992095
126STK240.15836134
127MST40.15549920
128MAP2K30.15243416
129PIK3CG0.14391780
130CDK190.14296759
131KSR10.14259579
132MAP2K70.12870414
133LCK0.12574167
134ROCK10.11965672
135PNCK0.11080184
136NLK0.11026132
137PAK60.10915174
138BCKDK0.10342742
139RPS6KL10.08676732
140RPS6KC10.08676732
141STK30.08403050
142MAP2K40.07633292

Predicted pathways (KEGG)

RankGene SetZ-score
1* Systemic lupus erythematosus_Homo sapiens_hsa053229.07090392
2* Alcoholism_Homo sapiens_hsa050344.99663720
3DNA replication_Homo sapiens_hsa030303.93291853
4Ribosome_Homo sapiens_hsa030103.65866427
5Mismatch repair_Homo sapiens_hsa034303.50123926
6One carbon pool by folate_Homo sapiens_hsa006702.89066654
7Viral carcinogenesis_Homo sapiens_hsa052032.72735481
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65472249
9Spliceosome_Homo sapiens_hsa030402.46399533
10Homologous recombination_Homo sapiens_hsa034402.25375851
11RNA transport_Homo sapiens_hsa030132.22237581
12Cell cycle_Homo sapiens_hsa041102.17639465
13Nucleotide excision repair_Homo sapiens_hsa034202.07226007
14Base excision repair_Homo sapiens_hsa034102.06053514
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90243389
16Non-homologous end-joining_Homo sapiens_hsa034501.90191205
17Fanconi anemia pathway_Homo sapiens_hsa034601.87288693
18RNA polymerase_Homo sapiens_hsa030201.57359702
19Pyrimidine metabolism_Homo sapiens_hsa002401.43549954
20mRNA surveillance pathway_Homo sapiens_hsa030151.39934007
21Transcriptional misregulation in cancer_Homo sapiens_hsa052021.38644880
22p53 signaling pathway_Homo sapiens_hsa041151.24260545
23Antigen processing and presentation_Homo sapiens_hsa046121.20647355
24RNA degradation_Homo sapiens_hsa030181.16837962
25Proteasome_Homo sapiens_hsa030501.03351168
26Graft-versus-host disease_Homo sapiens_hsa053320.98805589
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89322929
28Selenocompound metabolism_Homo sapiens_hsa004500.85032808
29MicroRNAs in cancer_Homo sapiens_hsa052060.84598230
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78999666
31Oocyte meiosis_Homo sapiens_hsa041140.72949607
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68174177
33Epstein-Barr virus infection_Homo sapiens_hsa051690.67147796
34Small cell lung cancer_Homo sapiens_hsa052220.64904595
35HTLV-I infection_Homo sapiens_hsa051660.64204465
36Intestinal immune network for IgA production_Homo sapiens_hsa046720.63914361
37Basal transcription factors_Homo sapiens_hsa030220.62423614
38Purine metabolism_Homo sapiens_hsa002300.56513175
39Bladder cancer_Homo sapiens_hsa052190.55570300
40Herpes simplex infection_Homo sapiens_hsa051680.54249426
41Apoptosis_Homo sapiens_hsa042100.52487210
42Thyroid cancer_Homo sapiens_hsa052160.48457319
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46992804
44Biosynthesis of amino acids_Homo sapiens_hsa012300.46986135
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45022161
46Chronic myeloid leukemia_Homo sapiens_hsa052200.43573882
47N-Glycan biosynthesis_Homo sapiens_hsa005100.43078913
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.42694506
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41972350
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41945007
51Asthma_Homo sapiens_hsa053100.41675661
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40510273
53Measles_Homo sapiens_hsa051620.40288103
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39432407
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38353189
56Non-small cell lung cancer_Homo sapiens_hsa052230.36964287
57Viral myocarditis_Homo sapiens_hsa054160.36847899
58Hepatitis B_Homo sapiens_hsa051610.36627964
59Inositol phosphate metabolism_Homo sapiens_hsa005620.35706041
60Endometrial cancer_Homo sapiens_hsa052130.35547102
61Allograft rejection_Homo sapiens_hsa053300.35406101
62Basal cell carcinoma_Homo sapiens_hsa052170.35115835
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.34667757
64Type I diabetes mellitus_Homo sapiens_hsa049400.33088547
65Lysine degradation_Homo sapiens_hsa003100.32252397
66Sulfur relay system_Homo sapiens_hsa041220.31479016
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31063936
68Colorectal cancer_Homo sapiens_hsa052100.30159402
69Primary immunodeficiency_Homo sapiens_hsa053400.28218513
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.27304440
71Vitamin B6 metabolism_Homo sapiens_hsa007500.26465009
72Pentose phosphate pathway_Homo sapiens_hsa000300.26087743
73Hippo signaling pathway_Homo sapiens_hsa043900.25818085
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.25036810
75Notch signaling pathway_Homo sapiens_hsa043300.24761651
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24740909
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24591292
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.24398018
79Legionellosis_Homo sapiens_hsa051340.24037055
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23286736
81Fructose and mannose metabolism_Homo sapiens_hsa000510.23272131
82Galactose metabolism_Homo sapiens_hsa000520.22473330
83TGF-beta signaling pathway_Homo sapiens_hsa043500.21809791
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21631236
85Folate biosynthesis_Homo sapiens_hsa007900.20568833
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19953931
87Proteoglycans in cancer_Homo sapiens_hsa052050.19696635
88Pancreatic cancer_Homo sapiens_hsa052120.19137447
89Hematopoietic cell lineage_Homo sapiens_hsa046400.17917846
90Pathways in cancer_Homo sapiens_hsa052000.17681230
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.17501093
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17331944
93Adherens junction_Homo sapiens_hsa045200.16343149
94Prostate cancer_Homo sapiens_hsa052150.15751148
95ErbB signaling pathway_Homo sapiens_hsa040120.15626525
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.15436028
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.15092732
98T cell receptor signaling pathway_Homo sapiens_hsa046600.14465850
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14042380
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.13078765
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12855232
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.12591666
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.12398971
104Tight junction_Homo sapiens_hsa045300.11456727
105Melanoma_Homo sapiens_hsa052180.10937367
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.10570682
107Leishmaniasis_Homo sapiens_hsa051400.10538835
108Nitrogen metabolism_Homo sapiens_hsa009100.10365334
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.10244555
110HIF-1 signaling pathway_Homo sapiens_hsa040660.09725052
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.08719114
112Glutathione metabolism_Homo sapiens_hsa004800.07429480
113VEGF signaling pathway_Homo sapiens_hsa043700.07089572
114B cell receptor signaling pathway_Homo sapiens_hsa046620.06966524
115Influenza A_Homo sapiens_hsa051640.06698659
116Shigellosis_Homo sapiens_hsa051310.06454370
117Renin-angiotensin system_Homo sapiens_hsa046140.06242952
118Autoimmune thyroid disease_Homo sapiens_hsa053200.06197625
119Carbon metabolism_Homo sapiens_hsa012000.06005123
120Glioma_Homo sapiens_hsa052140.05811991
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.04632890
122Acute myeloid leukemia_Homo sapiens_hsa052210.04349711
123FoxO signaling pathway_Homo sapiens_hsa040680.04347087
124mTOR signaling pathway_Homo sapiens_hsa041500.04180445
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.03144198
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.02800758

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