HIST1H2AG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1organ or tissue specific immune response (GO:0002251)8.42287298
2DNA replication-dependent nucleosome assembly (GO:0006335)7.70056210
3DNA replication-dependent nucleosome organization (GO:0034723)7.70056210
4chromatin assembly (GO:0031497)6.13664470
5nucleosome assembly (GO:0006334)6.00049885
6DNA unwinding involved in DNA replication (GO:0006268)5.87590747
7regulation of histone H3-K9 methylation (GO:0051570)5.76787424
8mitotic chromosome condensation (GO:0007076)5.64189108
9protein localization to kinetochore (GO:0034501)5.57634128
10nucleosome organization (GO:0034728)5.27669240
11chromatin assembly or disassembly (GO:0006333)5.26796813
12protein-DNA complex assembly (GO:0065004)5.14975989
13sister chromatid segregation (GO:0000819)5.11793383
14nuclear pore organization (GO:0006999)5.05670107
15nuclear pore complex assembly (GO:0051292)5.05221042
16protein localization to chromosome, centromeric region (GO:0071459)4.95304405
17mitotic sister chromatid segregation (GO:0000070)4.88654394
18kinetochore organization (GO:0051383)4.85275241
19DNA replication initiation (GO:0006270)4.73298679
20negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.72314872
21protein-DNA complex subunit organization (GO:0071824)4.67634320
22DNA strand elongation involved in DNA replication (GO:0006271)4.64835087
23chromatin remodeling at centromere (GO:0031055)4.61383670
24CENP-A containing nucleosome assembly (GO:0034080)4.60815255
25regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.56506266
26telomere maintenance via semi-conservative replication (GO:0032201)4.44198758
27DNA strand elongation (GO:0022616)4.41976802
28antibacterial humoral response (GO:0019731)4.39959525
29mitotic recombination (GO:0006312)4.26598299
30DNA replication-independent nucleosome organization (GO:0034724)4.18524302
31DNA replication-independent nucleosome assembly (GO:0006336)4.18524302
32attachment of spindle microtubules to kinetochore (GO:0008608)4.18086334
33meiotic chromosome segregation (GO:0045132)4.14744188
34innate immune response in mucosa (GO:0002227)4.14464064
35regulation of DNA endoreduplication (GO:0032875)4.13961744
36antimicrobial humoral response (GO:0019730)4.11086509
37telomere maintenance via recombination (GO:0000722)4.04691939
38mitotic metaphase plate congression (GO:0007080)4.00730068
39DNA topological change (GO:0006265)3.98010854
40positive regulation of mitotic sister chromatid separation (GO:1901970)3.96440229
41positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.96440229
42positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.96440229
43mitotic nuclear envelope disassembly (GO:0007077)3.93497783
44viral mRNA export from host cell nucleus (GO:0046784)3.91550452
45DNA geometric change (GO:0032392)3.90167551
46DNA duplex unwinding (GO:0032508)3.88885683
47DNA replication checkpoint (GO:0000076)3.88715099
48pore complex assembly (GO:0046931)3.88392944
49histone exchange (GO:0043486)3.87816583
50positive regulation of chromosome segregation (GO:0051984)3.87761509
51protoporphyrinogen IX metabolic process (GO:0046501)3.87711131
52regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.86982787
53regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.86489809
54folic acid-containing compound biosynthetic process (GO:0009396)3.82689947
55metaphase plate congression (GO:0051310)3.78499769
56chromosome condensation (GO:0030261)3.77636173
57mitotic sister chromatid cohesion (GO:0007064)3.75327554
58kinetochore assembly (GO:0051382)3.68935842
59nuclear envelope disassembly (GO:0051081)3.68450208
60membrane disassembly (GO:0030397)3.68450208
61translesion synthesis (GO:0019985)3.66822571
62establishment of chromosome localization (GO:0051303)3.66142219
63regulation of centrosome cycle (GO:0046605)3.64901194
64regulation of centriole replication (GO:0046599)3.64553668
65replicative senescence (GO:0090399)3.63286476
66defense response to Gram-positive bacterium (GO:0050830)3.62180729
67regulation of spindle organization (GO:0090224)3.61611716
68IMP biosynthetic process (GO:0006188)3.59030725
69protoporphyrinogen IX biosynthetic process (GO:0006782)3.52768688
70protein K6-linked ubiquitination (GO:0085020)3.52562977
71nucleotide-excision repair, DNA gap filling (GO:0006297)3.52096705
72regulation of megakaryocyte differentiation (GO:0045652)3.49251998
73V(D)J recombination (GO:0033151)3.48860605
74telomere maintenance via telomere lengthening (GO:0010833)3.47440387
75DNA conformation change (GO:0071103)3.45733593
76chromosome segregation (GO:0007059)3.39797285
77regulation of gene silencing (GO:0060968)3.38371755
78protein localization to chromosome (GO:0034502)3.36850171
79regulation of sister chromatid cohesion (GO:0007063)3.36453732
80DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.36145731
81microtubule depolymerization (GO:0007019)3.36097436
82regulation of chromosome segregation (GO:0051983)3.34383703
83ATP-dependent chromatin remodeling (GO:0043044)3.33156997
84somatic hypermutation of immunoglobulin genes (GO:0016446)3.31718805
85somatic diversification of immune receptors via somatic mutation (GO:0002566)3.31718805
86DNA packaging (GO:0006323)3.31110357
87IMP metabolic process (GO:0046040)3.30018490
88telomere maintenance (GO:0000723)3.29733922
89postreplication repair (GO:0006301)3.29469957
90spindle checkpoint (GO:0031577)3.28281881
91maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.27747510
92regulation of mitotic spindle organization (GO:0060236)3.27166294
93regulation of mitotic metaphase/anaphase transition (GO:0030071)3.26471547
94telomere organization (GO:0032200)3.25981898
95dosage compensation (GO:0007549)3.24904240
96negative regulation of histone methylation (GO:0031061)3.24703678
97double-strand break repair via nonhomologous end joining (GO:0006303)3.24216380
98non-recombinational repair (GO:0000726)3.24216380
99regulation of centrosome duplication (GO:0010824)3.21754454
100regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.17644096
101spindle assembly checkpoint (GO:0071173)3.14445816
102replication fork processing (GO:0031297)3.14320564
103DNA synthesis involved in DNA repair (GO:0000731)3.13793964
104mucosal immune response (GO:0002385)3.12378311
105mitochondrial DNA metabolic process (GO:0032042)3.11971738
106regulation of translational fidelity (GO:0006450)3.10906500
107regulation of mitotic sister chromatid separation (GO:0010965)3.08531509
108regulation of mitotic sister chromatid segregation (GO:0033047)3.08531509
109regulation of sister chromatid segregation (GO:0033045)3.08531509
110viral transcription (GO:0019083)3.04227194
111negative regulation of chromosome segregation (GO:0051985)3.04079549
112translational termination (GO:0006415)3.01600878
113mitotic DNA integrity checkpoint (GO:0044774)2.99871521
114DNA damage response, signal transduction resulting in transcription (GO:0042772)2.99594239
115histone phosphorylation (GO:0016572)2.95615014
116peptidyl-lysine dimethylation (GO:0018027)2.91924251
117somatic cell DNA recombination (GO:0016444)2.89549244
118somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.89549244
119rRNA transcription (GO:0009303)2.80998746
120regulation of spindle checkpoint (GO:0090231)2.78643556
121proline biosynthetic process (GO:0006561)2.78456533
122spindle assembly (GO:0051225)2.75773132
123mitotic spindle assembly checkpoint (GO:0007094)2.74121914
124somatic diversification of immune receptors (GO:0002200)2.73710317
125nucleobase-containing small molecule interconversion (GO:0015949)2.72300844
126negative regulation of mitotic sister chromatid segregation (GO:0033048)2.70877985

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.40780106
2* FOXM1_23109430_ChIP-Seq_U2OS_Human5.28255768
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.66586642
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.24856506
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.15391393
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.89741089
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.78309947
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.54099126
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.52586009
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.39073089
11* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.32788954
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.06078202
13* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03908887
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse12.1628400
15* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97453380
16AR_21909140_ChIP-Seq_LNCAP_Human1.97124015
17EGR1_19374776_ChIP-ChIP_THP-1_Human1.94527403
18MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79655771
19SOX2_16153702_ChIP-ChIP_HESCs_Human1.76336232
20CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.71341477
21VDR_23849224_ChIP-Seq_CD4+_Human1.68716622
22IRF1_19129219_ChIP-ChIP_H3396_Human1.67156232
23ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62992536
24* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.61518216
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56027154
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53458363
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49805659
28* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49718727
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49699969
30* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.48771600
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48455173
32ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45864124
33* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41221626
34MYC_22102868_ChIP-Seq_BL_Human1.40147026
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36004183
36* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.33810060
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33227979
38SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32309679
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.31161254
40XRN2_22483619_ChIP-Seq_HELA_Human1.31041683
41KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.30565960
42* ELK1_19687146_ChIP-ChIP_HELA_Human1.27886130
43FOXP3_21729870_ChIP-Seq_TREG_Human1.27386537
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26140199
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.23008352
46* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21740566
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20409144
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20156299
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19614139
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18769385
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18353487
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16941546
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15646408
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.14029260
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13624114
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12679921
57* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11868891
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11430163
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09026387
60* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08983409
61VDR_21846776_ChIP-Seq_THP-1_Human1.07204580
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05981806
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05628975
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04245614
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04147101
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00382840
67* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00205200
68CIITA_25753668_ChIP-Seq_RAJI_Human0.98651873
69ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97485332
70NANOG_16153702_ChIP-ChIP_HESCs_Human0.96577775
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95975024
72GABP_17652178_ChIP-ChIP_JURKAT_Human0.94885756
73DCP1A_22483619_ChIP-Seq_HELA_Human0.93328432
74TTF2_22483619_ChIP-Seq_HELA_Human0.92715412
75* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92546747
76NOTCH1_21737748_ChIP-Seq_TLL_Human0.92046004
77HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91601641
78* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.90692186
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90683538
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90482387
81KDM5A_27292631_Chip-Seq_BREAST_Human0.89605539
82* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89347073
83PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88557271
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.86895891
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85963702
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85825268
87JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.85658215
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82766706
89PKCTHETA_26484144_Chip-Seq_BREAST_Human0.79837815
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79507493
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79226479
92MYC_18940864_ChIP-ChIP_HL60_Human0.78796740
93* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.78651055
94ELF1_17652178_ChIP-ChIP_JURKAT_Human0.78635882
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.78179348
96GATA2_22383799_ChIP-Seq_G1ME_Mouse0.77112381
97ETS1_22383799_ChIP-Seq_G1ME_Mouse0.76916144
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.76851426
99RBPJ_22232070_ChIP-Seq_NCS_Mouse0.76639574
100GATA1_22383799_ChIP-Seq_G1ME_Mouse0.73155116
101GABP_19822575_ChIP-Seq_HepG2_Human0.73046996
102MAF_26560356_Chip-Seq_TH1_Human0.72557720
103VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.72024314
104GATA1_22025678_ChIP-Seq_K562_Human0.71733398
105MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.69358894
106UTX_26944678_Chip-Seq_JUKART_Human0.69089821
107SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.68007179
108NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.67044192
109* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.63169286
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.62710859
111MYB_26560356_Chip-Seq_TH1_Human0.56553449

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.26739629
2MP0003111_abnormal_nucleus_morphology4.82536076
3MP0003693_abnormal_embryo_hatching4.71253608
4MP0003077_abnormal_cell_cycle4.15925981
5MP0004957_abnormal_blastocyst_morpholog3.72139127
6MP0008057_abnormal_DNA_replication3.60281847
7MP0010307_abnormal_tumor_latency3.49572035
8MP0008058_abnormal_DNA_repair2.87603797
9MP0003656_abnormal_erythrocyte_physiolo2.82773022
10MP0010352_gastrointestinal_tract_polyps2.63055409
11MP0005076_abnormal_cell_differentiation2.51556412
12MP0004147_increased_porphyrin_level2.47590217
13MP0002396_abnormal_hematopoietic_system2.37594670
14MP0000350_abnormal_cell_proliferation2.33986685
15MP0003123_paternal_imprinting2.29725678
16MP0008007_abnormal_cellular_replicative2.27498115
17MP0001730_embryonic_growth_arrest2.26283263
18MP0008932_abnormal_embryonic_tissue2.25654878
19MP0001661_extended_life_span2.20167421
20MP0009697_abnormal_copulation2.07982776
21MP0004808_abnormal_hematopoietic_stem2.07410899
22MP0000490_abnormal_crypts_of1.97067633
23MP0008877_abnormal_DNA_methylation1.95562328
24MP0005464_abnormal_platelet_physiology1.81247953
25MP0003121_genomic_imprinting1.73239962
26MP0002019_abnormal_tumor_incidence1.69116837
27MP0001672_abnormal_embryogenesis/_devel1.64361036
28MP0005380_embryogenesis_phenotype1.64361036
29MP0001697_abnormal_embryo_size1.64136051
30MP0006054_spinal_hemorrhage1.61771835
31MP0002086_abnormal_extraembryonic_tissu1.61015994
32MP0004197_abnormal_fetal_growth/weight/1.56719600
33MP0002080_prenatal_lethality1.54447765
34MP0003705_abnormal_hypodermis_morpholog1.54132454
35MP0003718_maternal_effect1.51796128
36MP0000313_abnormal_cell_death1.50084976
37MP0001986_abnormal_taste_sensitivity1.47513716
38MP0005645_abnormal_hypothalamus_physiol1.47196019
39MP0002085_abnormal_embryonic_tissue1.46648464
40MP0000703_abnormal_thymus_morphology1.46210870
41MP0002084_abnormal_developmental_patter1.46122844
42MP0003984_embryonic_growth_retardation1.45325949
43MP0002398_abnormal_bone_marrow1.43525399
44MP0002088_abnormal_embryonic_growth/wei1.42459834
45MP0005397_hematopoietic_system_phenotyp1.40049793
46MP0001545_abnormal_hematopoietic_system1.40049793
47MP0003786_premature_aging1.37686756
48MP0002722_abnormal_immune_system1.35004823
49MP0000358_abnormal_cell_content/1.34733724
50MP0000465_gastrointestinal_hemorrhage1.34632196
51MP0006035_abnormal_mitochondrial_morpho1.27284669
52MP0000015_abnormal_ear_pigmentation1.27206737
53MP0000689_abnormal_spleen_morphology1.22333351
54MP0003448_altered_tumor_morphology1.21543682
55MP0002163_abnormal_gland_morphology1.21114286
56MP0003890_abnormal_embryonic-extraembry1.18077933
57MP0010234_abnormal_vibrissa_follicle1.13706164
58MP0001835_abnormal_antigen_presentation1.12648373
59MP0002166_altered_tumor_susceptibility1.12423478
60MP0005220_abnormal_exocrine_pancreas1.12313804
61MP0002429_abnormal_blood_cell1.06771011
62MP0003300_gastrointestinal_ulcer1.03996477
63MP0005083_abnormal_biliary_tract1.02815538
64MP0003787_abnormal_imprinting1.02167367
65MP0001293_anophthalmia1.00913728
66MP0003566_abnormal_cell_adhesion0.99835407
67MP0003453_abnormal_keratinocyte_physiol0.99142755
68MP0009672_abnormal_birth_weight0.98946648
69MP0003567_abnormal_fetal_cardiomyocyte0.98127843
70MP0002006_tumorigenesis0.97351632
71MP0002160_abnormal_reproductive_system0.93783227
72MP0009703_decreased_birth_body0.91101633
73MP0008995_early_reproductive_senescence0.89766207
74MP0000716_abnormal_immune_system0.89325008
75MP0003303_peritoneal_inflammation0.89229262
76MP0001800_abnormal_humoral_immune0.88124419
77MP0002877_abnormal_melanocyte_morpholog0.87647149
78MP0001915_intracranial_hemorrhage0.86433767
79MP0005621_abnormal_cell_physiology0.86424770
80MP0008770_decreased_survivor_rate0.86298949
81MP0005384_cellular_phenotype0.84901163
82MP0002009_preneoplasia0.84787524
83MP0003436_decreased_susceptibility_to0.81918207
84MP0009278_abnormal_bone_marrow0.81073999
85MP0003806_abnormal_nucleotide_metabolis0.80067350
86MP0004233_abnormal_muscle_weight0.79409937
87MP0002452_abnormal_antigen_presenting0.79179574
88MP0002095_abnormal_skin_pigmentation0.76419036
89MP0009333_abnormal_splenocyte_physiolog0.76319298
90MP0005501_abnormal_skin_physiology0.76255012
91MP0003763_abnormal_thymus_physiology0.76159225
92MP0001727_abnormal_embryo_implantation0.75838623
93MP0002111_abnormal_tail_morphology0.75334550
94MP0002420_abnormal_adaptive_immunity0.74833123
95MP0000858_altered_metastatic_potential0.74322110
96MP0005310_abnormal_salivary_gland0.73777489
97MP0001191_abnormal_skin_condition0.73049199
98MP0001819_abnormal_immune_cell0.72942770
99MP0002210_abnormal_sex_determination0.72861970
100MP0000685_abnormal_immune_system0.71539610
101MP0001145_abnormal_male_reproductive0.71375987
102MP0002092_abnormal_eye_morphology0.70990370
103MP0000013_abnormal_adipose_tissue0.70705822
104MP0005023_abnormal_wound_healing0.69910769
105MP0003937_abnormal_limbs/digits/tail_de0.69650439
106MP0004185_abnormal_adipocyte_glucose0.69531629
107MP0003699_abnormal_female_reproductive0.69039767
108MP0000537_abnormal_urethra_morphology0.68879886
109MP0000733_abnormal_muscle_development0.68431850
110MP0000477_abnormal_intestine_morphology0.65662671
111MP0010030_abnormal_orbit_morphology0.64518007
112MP0001929_abnormal_gametogenesis0.64458865
113MP0002925_abnormal_cardiovascular_devel0.64154988
114MP0001849_ear_inflammation0.64117577
115MP0009053_abnormal_anal_canal0.63773336
116MP0008873_increased_physiological_sensi0.62643821
117MP0002697_abnormal_eye_size0.62245456
118MP0005623_abnormal_meninges_morphology0.60819978
119MP0000003_abnormal_adipose_tissue0.60531535
120MP0001119_abnormal_female_reproductive0.60025720
121MP0001873_stomach_inflammation0.59868451
122MP0004381_abnormal_hair_follicle0.59390256
123MP0000428_abnormal_craniofacial_morphol0.58032670
124MP0003252_abnormal_bile_duct0.57795308
125MP0004264_abnormal_extraembryonic_tissu0.57753364
126MP0010678_abnormal_skin_adnexa0.57634928
127MP0003221_abnormal_cardiomyocyte_apopto0.56993411
128MP0005000_abnormal_immune_tolerance0.56178878
129MP0000653_abnormal_sex_gland0.55863323
130MP0005647_abnormal_sex_gland0.55464643
131MP0005171_absent_coat_pigmentation0.54345208
132MP0005451_abnormal_body_composition0.54120070
133MP0002161_abnormal_fertility/fecundity0.53681329
134MP0002083_premature_death0.53658416

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)4.96313756
2Chromsome breakage (HP:0040012)4.73375150
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.42111066
4IgA deficiency (HP:0002720)4.38072847
5Reticulocytopenia (HP:0001896)4.02333255
6Abnormality of chromosome stability (HP:0003220)3.99876692
7Hypochromic microcytic anemia (HP:0004840)3.93794100
8Colitis (HP:0002583)3.85222334
9Abnormality of the heme biosynthetic pathway (HP:0010472)3.78612190
10Birth length less than 3rd percentile (HP:0003561)3.69013851
11Impulsivity (HP:0100710)3.37987265
12Agnosia (HP:0010524)3.21102422
13Volvulus (HP:0002580)3.10270111
14Acanthocytosis (HP:0001927)3.06029061
15Ependymoma (HP:0002888)3.05869131
16Meckel diverticulum (HP:0002245)3.05615676
17Abnormality of reticulocytes (HP:0004312)3.03671566
18Abnormality of the preputium (HP:0100587)3.03662599
19Prominent nose (HP:0000448)3.02726373
20Increased mean platelet volume (HP:0011877)3.02008033
21Medulloblastoma (HP:0002885)3.00917941
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.96359817
23High pitched voice (HP:0001620)2.93583653
24Abnormality of the ileum (HP:0001549)2.91751635
25Basal cell carcinoma (HP:0002671)2.86203389
26Cutaneous melanoma (HP:0012056)2.85107226
27Abnormal platelet volume (HP:0011876)2.83283189
28Selective tooth agenesis (HP:0001592)2.82121745
29Abnormality of cells of the erythroid lineage (HP:0012130)2.79875008
30Duodenal stenosis (HP:0100867)2.79007304
31Small intestinal stenosis (HP:0012848)2.79007304
32Colon cancer (HP:0003003)2.76347415
33Myelodysplasia (HP:0002863)2.75864686
34Increased nuchal translucency (HP:0010880)2.74422140
35Cafe-au-lait spot (HP:0000957)2.64685349
36B lymphocytopenia (HP:0010976)2.63163677
37Rhabdomyosarcoma (HP:0002859)2.62168847
38Hypochromic anemia (HP:0001931)2.60230107
39Short 4th metacarpal (HP:0010044)2.57701160
40Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.57701160
41Patellar aplasia (HP:0006443)2.56048912
42Ectopic kidney (HP:0000086)2.54782306
43Abnormality of pyrimidine metabolism (HP:0004353)2.52649069
44Macrocytic anemia (HP:0001972)2.51884623
45Abnormality of the fingertips (HP:0001211)2.50151559
46Reticulocytosis (HP:0001923)2.48174366
47Microvesicular hepatic steatosis (HP:0001414)2.45100346
48Abnormal number of erythroid precursors (HP:0012131)2.45048621
49Abnormality of the labia minora (HP:0012880)2.44424447
50Petechiae (HP:0000967)2.40975472
51Abnormality of the carotid arteries (HP:0005344)2.39558966
52Abnormality of the renal collecting system (HP:0004742)2.39010312
53Abnormality of B cell number (HP:0010975)2.38839073
54Pallor (HP:0000980)2.37717557
55Inflammation of the large intestine (HP:0002037)2.36655985
56Sloping forehead (HP:0000340)2.36061762
57Biliary tract neoplasm (HP:0100574)2.35124448
58Gastrointestinal stroma tumor (HP:0100723)2.34977098
59Abnormality of the astrocytes (HP:0100707)2.34656614
60Astrocytoma (HP:0009592)2.34656614
61Aplasia/Hypoplasia of the patella (HP:0006498)2.33232450
62Absent thumb (HP:0009777)2.31995139
63Aplasia/Hypoplasia of the sacrum (HP:0008517)2.31867701
64Abnormality of the duodenum (HP:0002246)2.29411814
65Amaurosis fugax (HP:0100576)2.28761764
66Squamous cell carcinoma (HP:0002860)2.27604181
67Embryonal renal neoplasm (HP:0011794)2.24598869
68Poikiloderma (HP:0001029)2.23770856
69IgM deficiency (HP:0002850)2.19656957
70Gastrointestinal inflammation (HP:0004386)2.19103516
7111 pairs of ribs (HP:0000878)2.18306644
72Hypergonadotropic hypogonadism (HP:0000815)2.18281959
73Progressive external ophthalmoplegia (HP:0000590)2.17890971
74Acute lymphatic leukemia (HP:0006721)2.17672231
75Ureteral duplication (HP:0000073)2.17273324
76Deviation of the thumb (HP:0009603)2.16689410
77Proximal placement of thumb (HP:0009623)2.16604265
78Long eyelashes (HP:0000527)2.14907923
79Leiomyosarcoma (HP:0100243)2.14278176
80Uterine leiomyosarcoma (HP:0002891)2.14278176
81Insomnia (HP:0100785)2.13924383
82Breast hypoplasia (HP:0003187)2.13864562
83Hypoplasia of the pons (HP:0012110)2.13639751
84Agammaglobulinemia (HP:0004432)2.12222194
85Duplicated collecting system (HP:0000081)2.10872998
86Sandal gap (HP:0001852)2.10689354
87Abnormal number of incisors (HP:0011064)2.10518375
88Papilledema (HP:0001085)2.09127573
89Thrombocytosis (HP:0001894)2.08778379
90Bone marrow hypocellularity (HP:0005528)2.08391600
91Neoplasm of the pancreas (HP:0002894)2.07788430
92Cortical dysplasia (HP:0002539)2.06380266
93Glioma (HP:0009733)2.06117341
94Neoplasm of the oral cavity (HP:0100649)2.05879207
95Arteriovenous malformation (HP:0100026)2.03454592
96Lymphoma (HP:0002665)2.02557861
97Clubbing of toes (HP:0100760)2.02344296
98Abnormality of the pons (HP:0007361)2.00283915
99Abnormal lung lobation (HP:0002101)1.99579289
100Absent radius (HP:0003974)1.97827074
101Gastrointestinal carcinoma (HP:0002672)1.95944544
102Malignant gastrointestinal tract tumors (HP:0006749)1.95944544
103Prostate neoplasm (HP:0100787)1.95295270
104Dyschromatopsia (HP:0007641)1.94812715
105Prolonged bleeding time (HP:0003010)1.94616590
106Hypoplasia of the capital femoral epiphysis (HP:0003090)1.93686707
107Tracheoesophageal fistula (HP:0002575)1.91309161
108Neoplasm of striated muscle (HP:0009728)1.89207049
109Cutaneous photosensitivity (HP:0000992)1.89120051
110Oral leukoplakia (HP:0002745)1.89077186
111Hyperacusis (HP:0010780)1.88231661
112Recurrent viral infections (HP:0004429)1.87310992
113Recurrent sinusitis (HP:0011108)1.87310397
114Autoimmune hemolytic anemia (HP:0001890)1.86954528
115Abnormality of DNA repair (HP:0003254)1.86816641
116Short thumb (HP:0009778)1.86068447
117Cutis marmorata (HP:0000965)1.84493578
118Nephroblastoma (Wilms tumor) (HP:0002667)1.82958989
119Entropion (HP:0000621)1.82951374
120Atresia of the external auditory canal (HP:0000413)1.81631565
121Abnormality of cells of the lymphoid lineage (HP:0012140)1.81482477
122Aplasia involving forearm bones (HP:0009822)1.80027168
123Absent forearm bone (HP:0003953)1.80027168
124Microtia (HP:0008551)1.79575198
125Thyroiditis (HP:0100646)1.79318314
126Leukopenia (HP:0001882)1.79040043
127Long clavicles (HP:0000890)1.78714274
128Orthostatic hypotension (HP:0001278)1.78408728
129Renovascular hypertension (HP:0100817)1.77945374
130Ankyloglossia (HP:0010296)1.77884354
131Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.76944745
132Ovarian neoplasm (HP:0100615)1.76503662
133Cellulitis (HP:0100658)1.76275043
134Rough bone trabeculation (HP:0100670)1.75322944
135Duplication of thumb phalanx (HP:0009942)1.75193392
136Freckling (HP:0001480)1.74390292
137Lymphopenia (HP:0001888)1.74109126
138Deep philtrum (HP:0002002)1.73783823
139Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.73282465
140Cellular immunodeficiency (HP:0005374)1.72910757
141Abnormality of cochlea (HP:0000375)1.72460532
142Bladder neoplasm (HP:0009725)1.72335220
143Bladder carcinoma (HP:0002862)1.72335220
144Dysautonomia (HP:0002459)1.71323699
145Panhypogammaglobulinemia (HP:0003139)1.69709767

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK18.45854571
2ZAK5.57492954
3CDC74.21793281
4VRK13.44030999
5STK43.36028160
6CDK122.65775977
7NEK22.63269946
8RPS6KA52.53410771
9WEE12.26870650
10BUB12.01243784
11AURKB1.91162717
12EIF2AK11.79707870
13SCYL21.78625760
14SRPK11.78265498
15MAP3K81.69649089
16PIM11.64546939
17MAP3K101.63275170
18CHEK21.62839506
19NEK11.54497322
20EEF2K1.52176628
21CDK91.49849085
22TTK1.47657726
23ATR1.37013079
24PLK11.35899553
25SMG11.26959162
26RPS6KB21.24082586
27DYRK31.23273885
28STK101.21242260
29CDK41.17580704
30AURKA1.12456132
31BRD41.11269401
32BRSK21.07237054
33TRIB31.06672705
34CDK71.00769824
35GRK60.99346847
36ACVR1B0.98661858
37CCNB10.96671604
38PKN20.93228497
39BLK0.93051208
40CHEK10.92895332
41NME20.90851993
42TESK20.88979085
43PLK30.87494825
44PLK40.85401331
45CAMK1D0.84217953
46BRSK10.84138835
47ATM0.80351364
48MELK0.73420450
49TAF10.73102137
50CDK20.71785527
51MKNK10.71337611
52DAPK30.70375663
53CDK60.69903599
54BRAF0.68895269
55MAP2K70.68719046
56PKN10.68268867
57PASK0.68222968
58MAP4K10.67228832
59PIM20.65174951
60EIF2AK30.64591379
61MAP3K40.63242307
62FLT30.62708558
63CDK80.62642767
64EPHA20.62127015
65MST40.60915626
66TSSK60.59227040
67IRAK30.59132861
68ICK0.58347979
69TTN0.56598482
70CDK10.55749198
71STK30.51560428
72AKT20.50286110
73RPS6KA40.49907616
74MKNK20.49010960
75RAF10.45422735
76MAP2K30.44423166
77PIK3CG0.44031161
78STK160.43931858
79DYRK1B0.43802175
80TESK10.40756109
81EIF2AK20.40563235
82ALK0.40240293
83PRKAA10.38567319
84CLK10.38456751
85MAPK110.38118123
86MAP2K40.37183442
87PBK0.36898498
88LRRK20.36589088
89CSNK1D0.35459712
90PAK40.34890870
91IRAK40.34663745
92CSNK2A20.34488137
93TRPM70.34289909
94NEK90.33554432
95CAMKK20.33267669
96TEC0.32019566
97PRKDC0.31914892
98CSF1R0.31149421
99PAK10.30488360
100MARK30.29485259
101MAPK140.27824944
102FRK0.24247367
103BTK0.23781386
104ILK0.23708784
105PRPF4B0.23289962
106CSNK2A10.22855142
107LYN0.21833040
108JAK20.21727631
109MTOR0.21215773
110MST1R0.20836695
111BMPR1B0.19887580
112AKT10.19268456
113BMPR20.18948247
114IRAK20.18833946
115CSNK1G30.18280601
116PRKCI0.17220162
117CSNK1G10.16976633
118PRKCQ0.15360837
119RPS6KL10.14909833
120RPS6KC10.14909833
121BMX0.14557504
122SYK0.14514065
123TGFBR10.14486397
124CSNK1A1L0.12681400
125RPS6KB10.12331613
126FGR0.11192882
127MAPKAPK50.10841943
128CAMK1G0.10826762
129GSK3B0.10413389
130MAPK10.10184090
131MAP2K20.10139563
132RET0.09963985
133CAMK40.09893746
134MAP3K20.07834606
135ARAF0.07112827
136MAP2K10.05923271

Predicted pathways (KEGG)

RankGene SetZ-score
1* Systemic lupus erythematosus_Homo sapiens_hsa053229.64788745
2* Alcoholism_Homo sapiens_hsa050345.33707308
3DNA replication_Homo sapiens_hsa030304.10018346
4Mismatch repair_Homo sapiens_hsa034303.33687537
5Viral carcinogenesis_Homo sapiens_hsa052032.96964314
6Cell cycle_Homo sapiens_hsa041102.50422830
7Homologous recombination_Homo sapiens_hsa034402.25787358
8Base excision repair_Homo sapiens_hsa034102.24717019
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.16404156
10Spliceosome_Homo sapiens_hsa030402.15382353
11One carbon pool by folate_Homo sapiens_hsa006702.13006074
12Nucleotide excision repair_Homo sapiens_hsa034202.06999060
13RNA transport_Homo sapiens_hsa030132.00411179
14Fanconi anemia pathway_Homo sapiens_hsa034601.99755278
15Non-homologous end-joining_Homo sapiens_hsa034501.96639270
16Ribosome_Homo sapiens_hsa030101.88084158
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.71436294
18Transcriptional misregulation in cancer_Homo sapiens_hsa052021.64728484
19Pyrimidine metabolism_Homo sapiens_hsa002401.39849867
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30740011
21p53 signaling pathway_Homo sapiens_hsa041151.29967197
22RNA polymerase_Homo sapiens_hsa030201.27421655
23mRNA surveillance pathway_Homo sapiens_hsa030151.26918030
24RNA degradation_Homo sapiens_hsa030181.04225272
25Proteasome_Homo sapiens_hsa030500.88354138
26Basal transcription factors_Homo sapiens_hsa030220.86953885
27MicroRNAs in cancer_Homo sapiens_hsa052060.86746474
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84322514
29Antigen processing and presentation_Homo sapiens_hsa046120.81661879
30Herpes simplex infection_Homo sapiens_hsa051680.79092430
31Oocyte meiosis_Homo sapiens_hsa041140.79079996
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78672951
33Small cell lung cancer_Homo sapiens_hsa052220.76712923
34Epstein-Barr virus infection_Homo sapiens_hsa051690.75854767
35HTLV-I infection_Homo sapiens_hsa051660.72605551
36Chronic myeloid leukemia_Homo sapiens_hsa052200.64795605
37Non-small cell lung cancer_Homo sapiens_hsa052230.62513722
38Selenocompound metabolism_Homo sapiens_hsa004500.61712862
39Apoptosis_Homo sapiens_hsa042100.58710499
40Purine metabolism_Homo sapiens_hsa002300.57403150
41Vitamin B6 metabolism_Homo sapiens_hsa007500.54185087
42Hematopoietic cell lineage_Homo sapiens_hsa046400.50827553
43Bladder cancer_Homo sapiens_hsa052190.50675979
44Hepatitis B_Homo sapiens_hsa051610.50238643
45NF-kappa B signaling pathway_Homo sapiens_hsa040640.45449760
46Lysine degradation_Homo sapiens_hsa003100.45064791
47Pentose phosphate pathway_Homo sapiens_hsa000300.44701404
48Measles_Homo sapiens_hsa051620.41734969
49Pancreatic cancer_Homo sapiens_hsa052120.38358157
50Primary immunodeficiency_Homo sapiens_hsa053400.38293311
51B cell receptor signaling pathway_Homo sapiens_hsa046620.35840377
52Prostate cancer_Homo sapiens_hsa052150.35296400
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34348595
54Legionellosis_Homo sapiens_hsa051340.34294801
55Sulfur relay system_Homo sapiens_hsa041220.33950106
56Asthma_Homo sapiens_hsa053100.33367173
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32832818
58Colorectal cancer_Homo sapiens_hsa052100.32615857
59N-Glycan biosynthesis_Homo sapiens_hsa005100.30263422
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.29950170
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29679867
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29446966
63Endometrial cancer_Homo sapiens_hsa052130.28628367
64mTOR signaling pathway_Homo sapiens_hsa041500.27970183
65Notch signaling pathway_Homo sapiens_hsa043300.27541921
66Thyroid cancer_Homo sapiens_hsa052160.27409262
67Biosynthesis of amino acids_Homo sapiens_hsa012300.27339404
68Glioma_Homo sapiens_hsa052140.26479944
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.26228239
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26099177
71Fructose and mannose metabolism_Homo sapiens_hsa000510.25104921
72Leishmaniasis_Homo sapiens_hsa051400.24945944
73Influenza A_Homo sapiens_hsa051640.24885826
74Renin-angiotensin system_Homo sapiens_hsa046140.24058113
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22458488
76Inositol phosphate metabolism_Homo sapiens_hsa005620.22182916
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.22158281
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22042392
79FoxO signaling pathway_Homo sapiens_hsa040680.21727349
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20623539
81Autoimmune thyroid disease_Homo sapiens_hsa053200.20433805
82Allograft rejection_Homo sapiens_hsa053300.20241746
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19743442
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19680595
85TGF-beta signaling pathway_Homo sapiens_hsa043500.19429317
86Carbon metabolism_Homo sapiens_hsa012000.18869427
87Folate biosynthesis_Homo sapiens_hsa007900.18381326
88Galactose metabolism_Homo sapiens_hsa000520.18373748
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.18231497
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18227977
91Melanoma_Homo sapiens_hsa052180.18042077
92Sulfur metabolism_Homo sapiens_hsa009200.17947696
93Viral myocarditis_Homo sapiens_hsa054160.17727518
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17464713
95Malaria_Homo sapiens_hsa051440.17366440
96Pathways in cancer_Homo sapiens_hsa052000.17122467
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16132103
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.15652738
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15312470
100HIF-1 signaling pathway_Homo sapiens_hsa040660.15250991
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15187006
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14755962
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.14530458
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13924168
105Acute myeloid leukemia_Homo sapiens_hsa052210.13200763
106Proteoglycans in cancer_Homo sapiens_hsa052050.12864034
107Platelet activation_Homo sapiens_hsa046110.11082635
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10971251
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.10655529
110Osteoclast differentiation_Homo sapiens_hsa043800.09244333
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.08556035
112Graft-versus-host disease_Homo sapiens_hsa053320.08348769
113Toxoplasmosis_Homo sapiens_hsa051450.08162221
114ErbB signaling pathway_Homo sapiens_hsa040120.08108592
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.07313989
116Adherens junction_Homo sapiens_hsa045200.07252921
117Shigellosis_Homo sapiens_hsa051310.06877304
118Basal cell carcinoma_Homo sapiens_hsa052170.06574246
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.06388750
120Arginine biosynthesis_Homo sapiens_hsa002200.06218253
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.06144959
122Glutathione metabolism_Homo sapiens_hsa004800.06046335
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.05237439
124Pyruvate metabolism_Homo sapiens_hsa006200.05184125
125Hippo signaling pathway_Homo sapiens_hsa043900.05178032
126Fatty acid biosynthesis_Homo sapiens_hsa000610.04265191

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