HIST1H2AJ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1innate immune response in mucosa (GO:0002227)9.91639012
2nucleosome assembly (GO:0006334)8.55606885
3mucosal immune response (GO:0002385)8.20663138
4antibacterial humoral response (GO:0019731)8.16915895
5chromatin assembly (GO:0031497)8.02480783
6regulation of histone H3-K9 methylation (GO:0051570)7.55642229
7antimicrobial humoral response (GO:0019730)7.46632724
8organ or tissue specific immune response (GO:0002251)7.41316238
9protein-DNA complex assembly (GO:0065004)7.36434544
10nucleosome organization (GO:0034728)7.11378148
11ribosomal small subunit biogenesis (GO:0042274)7.06513813
12nuclear pore complex assembly (GO:0051292)6.61544954
13DNA deamination (GO:0045006)6.39685892
14protein-DNA complex subunit organization (GO:0071824)6.30452956
15DNA strand elongation involved in DNA replication (GO:0006271)5.97822032
16chromatin assembly or disassembly (GO:0006333)5.95355020
17telomere maintenance via semi-conservative replication (GO:0032201)5.85706099
18nuclear pore organization (GO:0006999)5.76952807
19DNA strand elongation (GO:0022616)5.64759084
20viral transcription (GO:0019083)5.43629757
21DNA replication initiation (GO:0006270)5.42480582
22translational termination (GO:0006415)5.31119041
23mitotic chromosome condensation (GO:0007076)5.01151844
24pore complex assembly (GO:0046931)4.95903774
25telomere maintenance via recombination (GO:0000722)4.93975968
26mitotic recombination (GO:0006312)4.75861791
27translational elongation (GO:0006414)4.68414408
28DNA unwinding involved in DNA replication (GO:0006268)4.63652141
29ribosomal small subunit assembly (GO:0000028)4.61984839
30kinetochore assembly (GO:0051382)4.54438023
31SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.53645882
32sister chromatid segregation (GO:0000819)4.53016853
33ribonucleoprotein complex biogenesis (GO:0022613)4.48752003
34telomere maintenance via telomere lengthening (GO:0010833)4.48747304
35nucleotide-excision repair, DNA gap filling (GO:0006297)4.48379820
36kinetochore organization (GO:0051383)4.47583366
37cotranslational protein targeting to membrane (GO:0006613)4.42621095
38protein targeting to ER (GO:0045047)4.42514177
39maturation of SSU-rRNA (GO:0030490)4.37522608
40DNA replication checkpoint (GO:0000076)4.34926304
41translational initiation (GO:0006413)4.26246804
42establishment of protein localization to endoplasmic reticulum (GO:0072599)4.19328570
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.18808730
44cellular protein complex disassembly (GO:0043624)4.16219240
45protein localization to endoplasmic reticulum (GO:0070972)4.13706096
46regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.12996866
47chromatin remodeling at centromere (GO:0031055)4.10350600
48viral life cycle (GO:0019058)4.08388986
49CENP-A containing nucleosome assembly (GO:0034080)4.08164242
50negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.05071214
51formation of translation preinitiation complex (GO:0001731)4.03944099
52establishment of integrated proviral latency (GO:0075713)4.01200604
53deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.00479185
54DNA ligation (GO:0006266)3.89606751
55IMP biosynthetic process (GO:0006188)3.86294439
56DNA duplex unwinding (GO:0032508)3.85651318
57mitochondrial DNA replication (GO:0006264)3.84133923
58ribosome biogenesis (GO:0042254)3.83154554
59protein complex disassembly (GO:0043241)3.79903447
60non-recombinational repair (GO:0000726)3.77837960
61double-strand break repair via nonhomologous end joining (GO:0006303)3.77837960
62rRNA processing (GO:0006364)3.77564625
63nucleobase biosynthetic process (GO:0046112)3.76713979
64ribosomal large subunit biogenesis (GO:0042273)3.76416453
65regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.75996574
66deoxyribonucleotide biosynthetic process (GO:0009263)3.73886044
67DNA geometric change (GO:0032392)3.73814167
68DNA replication-dependent nucleosome assembly (GO:0006335)3.73733524
69DNA replication-dependent nucleosome organization (GO:0034723)3.73733524
70regulation of nuclear cell cycle DNA replication (GO:0033262)3.73597192
71pseudouridine synthesis (GO:0001522)3.71231522
72V(D)J recombination (GO:0033151)3.69086460
73translation (GO:0006412)3.64543505
74DNA replication-independent nucleosome assembly (GO:0006336)3.63327616
75DNA replication-independent nucleosome organization (GO:0034724)3.63327616
76spliceosomal snRNP assembly (GO:0000387)3.61180176
77macromolecular complex disassembly (GO:0032984)3.60263964
78rRNA metabolic process (GO:0016072)3.59011770
79transcription-coupled nucleotide-excision repair (GO:0006283)3.55148748
80regulation of centrosome cycle (GO:0046605)3.53147420
81positive regulation of histone methylation (GO:0031062)3.53046872
82proteasome assembly (GO:0043248)3.48682098
83mitotic sister chromatid cohesion (GO:0007064)3.48206015
84pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.47393966
85pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.46076508
86regulation of centriole replication (GO:0046599)3.44833823
87regulation of megakaryocyte differentiation (GO:0045652)3.43140429
88cellular component biogenesis (GO:0044085)3.42730700
89regulation of sister chromatid cohesion (GO:0007063)3.42492749
90sequestering of actin monomers (GO:0042989)3.42386418
91regulation of chromosome segregation (GO:0051983)3.38766641
92protein localization to kinetochore (GO:0034501)3.38503310
93viral mRNA export from host cell nucleus (GO:0046784)3.36629712
94regulation of double-strand break repair via homologous recombination (GO:0010569)3.35647148
95rRNA modification (GO:0000154)3.31164409
96exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.31062863
97mitochondrial DNA metabolic process (GO:0032042)3.30004825
98ATP-dependent chromatin remodeling (GO:0043044)3.29781397
99defense response to Gram-positive bacterium (GO:0050830)3.29485736
100deoxyribose phosphate biosynthetic process (GO:0046385)3.29151810
1012-deoxyribonucleotide biosynthetic process (GO:0009265)3.29151810
102DNA synthesis involved in DNA repair (GO:0000731)3.28534277
103purine nucleobase biosynthetic process (GO:0009113)3.28058265
104negative regulation of chromosome segregation (GO:0051985)3.27925841
105nucleobase-containing small molecule interconversion (GO:0015949)3.27871103
106mitotic metaphase plate congression (GO:0007080)3.27161339
107negative regulation of DNA repair (GO:0045738)3.26604803
108IMP metabolic process (GO:0046040)3.26596084
109somatic hypermutation of immunoglobulin genes (GO:0016446)3.26255840
110somatic diversification of immune receptors via somatic mutation (GO:0002566)3.26255840
111DNA topological change (GO:0006265)3.26047021
112nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.24904031
113nuclear-transcribed mRNA catabolic process (GO:0000956)3.24801579
114DNA conformation change (GO:0071103)3.23551253
115establishment of viral latency (GO:0019043)3.22790157
116DNA-dependent DNA replication (GO:0006261)3.22637776
117regulation of mitotic sister chromatid separation (GO:0010965)3.19987942
118regulation of mitotic sister chromatid segregation (GO:0033047)3.19987942
119regulation of sister chromatid segregation (GO:0033045)3.19987942
120regulation of mitotic metaphase/anaphase transition (GO:0030071)3.19115061
121regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.19115061
122regulation of centrosome duplication (GO:0010824)3.18519396
123regulation of gene silencing (GO:0060968)3.17407634
124metaphase plate congression (GO:0051310)3.16249573
125pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.14476896
126chromosome condensation (GO:0030261)3.13962191
127histone exchange (GO:0043486)3.13957024
128negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.13702606
129negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.13702606
130negative regulation of mitotic sister chromatid segregation (GO:0033048)3.13702606
131negative regulation of mitotic sister chromatid separation (GO:2000816)3.13702606
132negative regulation of sister chromatid segregation (GO:0033046)3.13702606
133meiotic chromosome segregation (GO:0045132)3.13530870
134mitotic sister chromatid segregation (GO:0000070)3.12899006
135maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.11120899
136termination of RNA polymerase II transcription (GO:0006369)3.11006025
137mitotic nuclear envelope disassembly (GO:0007077)3.10220726
138spliceosomal complex assembly (GO:0000245)3.10172431
139nuclear envelope disassembly (GO:0051081)3.09800967
140membrane disassembly (GO:0030397)3.09800967
141protoporphyrinogen IX metabolic process (GO:0046501)3.08651252
142protoporphyrinogen IX biosynthetic process (GO:0006782)3.07038288
143spindle checkpoint (GO:0031577)3.07024141
144protein localization to chromosome, centromeric region (GO:0071459)3.05913922
145mRNA catabolic process (GO:0006402)3.05751579
146mitotic spindle assembly checkpoint (GO:0007094)3.05699469
147positive regulation of chromosome segregation (GO:0051984)3.05331881
148inner cell mass cell proliferation (GO:0001833)3.04750106
149somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.03784109
150somatic cell DNA recombination (GO:0016444)3.03784109
151cell cycle G1/S phase transition (GO:0044843)3.02918709
152G1/S transition of mitotic cell cycle (GO:0000082)3.02918709
153spindle assembly checkpoint (GO:0071173)3.02739505
154positive regulation of mitotic sister chromatid separation (GO:1901970)3.01945741
155positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.01945741
156positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.01945741
157B cell receptor signaling pathway (GO:0050853)3.00015450
158telomere maintenance (GO:0000723)2.99900989
159UTP biosynthetic process (GO:0006228)2.99686676
160telomere organization (GO:0032200)2.99445159
161DNA replication (GO:0006260)2.98810383
162pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.97760275
163RNA catabolic process (GO:0006401)2.96945497
164regulation of mesoderm development (GO:2000380)2.95906628
165transcription elongation from RNA polymerase III promoter (GO:0006385)2.94803872
166termination of RNA polymerase III transcription (GO:0006386)2.94803872
167mitotic spindle checkpoint (GO:0071174)2.94349255
168translesion synthesis (GO:0019985)2.94037009
169folic acid metabolic process (GO:0046655)2.93187576
170pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.92865193

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.18735167
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.36942638
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.94697734
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.69128261
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.58496166
6* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.40108247
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.20544646
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.14423911
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.10010000
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.05546667
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.94824312
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88490881
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.87021475
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.80695163
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80020509
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.67263876
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.66048232
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58603169
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.50363110
20* SOX2_16153702_ChIP-ChIP_HESCs_Human2.50284766
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48038290
22POU5F1_16153702_ChIP-ChIP_HESCs_Human2.46435852
23XRN2_22483619_ChIP-Seq_HELA_Human2.44506231
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29655660
25GATA1_22025678_ChIP-Seq_K562_Human2.28959257
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27660420
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24720503
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17175586
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13108414
30DCP1A_22483619_ChIP-Seq_HELA_Human2.01352195
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse16.2985780
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.98918438
33VDR_23849224_ChIP-Seq_CD4+_Human1.98652011
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.93641240
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93329837
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91548093
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.88041058
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.83672546
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.81792013
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.79072057
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78933968
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.77875671
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.77875671
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.77875671
45TTF2_22483619_ChIP-Seq_HELA_Human1.76776706
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76729510
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.76426987
48HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.76202346
49FOXP3_21729870_ChIP-Seq_TREG_Human1.75583321
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75326309
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.75258879
52AR_21909140_ChIP-Seq_LNCAP_Human1.72702974
53GABP_19822575_ChIP-Seq_HepG2_Human1.67232575
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66175754
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64051109
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55343446
57SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.52146816
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51866535
59IRF1_19129219_ChIP-ChIP_H3396_Human1.51230174
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48065495
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44599405
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44331525
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42567799
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42488715
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42286369
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39796861
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.39568517
68TCF3_18692474_ChIP-Seq_MEFs_Mouse1.39132758
69MYC_22102868_ChIP-Seq_BL_Human1.38320881
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.37159496
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.36215455
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29403850
73ELK1_19687146_ChIP-ChIP_HELA_Human1.25241884
74SOX2_18692474_ChIP-Seq_MEFs_Mouse1.24919934
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24849298
76NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.24543652
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23678297
78FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21508822
79OCT4_18692474_ChIP-Seq_MEFs_Mouse1.20675684
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19507628
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17857823
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17718413
83MYC_18940864_ChIP-ChIP_HL60_Human1.16109301
84STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16033814
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13316965
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13085762
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12892678
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12685382
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12633530
90VDR_21846776_ChIP-Seq_THP-1_Human1.12296229
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.11474289
92PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09225356
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09144301
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08290304
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08243090
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07336373
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07089656
98SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04765159
99CIITA_25753668_ChIP-Seq_RAJI_Human1.02258077
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00742775
101VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99331175
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98930305
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98244072
104CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98089421
105SOX2_18692474_ChIP-Seq_MESCs_Mouse0.97996706
106KDM5A_27292631_Chip-Seq_BREAST_Human0.95902539
107NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.95608509
108EGR1_19374776_ChIP-ChIP_THP-1_Human0.94742679
109ETS1_22383799_ChIP-Seq_G1ME_Mouse0.93494533
110SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93113344
111NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92891757
112TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92731983
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91940099
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89913018
115POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.89884658
116RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89346335
117KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89275041
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88482634
119BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87648786
120TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86904379
121TP63_19390658_ChIP-ChIP_HaCaT_Human0.86423415
122SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84990961
123MAF_26560356_Chip-Seq_TH1_Human0.75033340
124PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.72387750
125RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.72119803
126CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70250781
127MYB_26560356_Chip-Seq_TH1_Human0.63418623
128* SALL4_22934838_ChIP-ChIP_CD34+_Human0.58330804
129ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.55706259
130PKCTHETA_26484144_Chip-Seq_BREAST_Human0.54713704
131ZNF263_19887448_ChIP-Seq_K562_Human0.54607538
132HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.54172299
133ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.52984813
134SOX17_20123909_ChIP-Seq_XEN_Mouse0.52044799
135GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.52037719

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.36471486
2MP0008057_abnormal_DNA_replication4.50805406
3MP0009379_abnormal_foot_pigmentation4.26462904
4MP0004957_abnormal_blastocyst_morpholog4.24812256
5MP0010094_abnormal_chromosome_stability4.04643649
6MP0003111_abnormal_nucleus_morphology3.44661113
7MP0003123_paternal_imprinting3.36819168
8MP0004133_heterotaxia3.33279548
9MP0003077_abnormal_cell_cycle3.29031385
10MP0008058_abnormal_DNA_repair3.04997689
11MP0003806_abnormal_nucleotide_metabolis2.92988193
12MP0002009_preneoplasia2.91381394
13MP0008932_abnormal_embryonic_tissue2.75880776
14MP0005645_abnormal_hypothalamus_physiol2.58837076
15MP0000685_abnormal_immune_system2.53201445
16MP0008007_abnormal_cellular_replicative2.37747907
17MP0010234_abnormal_vibrissa_follicle2.13421949
18MP0003890_abnormal_embryonic-extraembry2.11050696
19MP0002166_altered_tumor_susceptibility2.10063010
20MP0003119_abnormal_digestive_system2.04753460
21MP0005083_abnormal_biliary_tract2.03199028
22MP0001730_embryonic_growth_arrest1.93591135
23MP0010352_gastrointestinal_tract_polyps1.92671095
24MP0006292_abnormal_olfactory_placode1.92546063
25MP0009697_abnormal_copulation1.91385548
26MP0000350_abnormal_cell_proliferation1.90260300
27MP0003763_abnormal_thymus_physiology1.90207932
28MP0000490_abnormal_crypts_of1.81986834
29MP0003786_premature_aging1.80523835
30MP0003656_abnormal_erythrocyte_physiolo1.75004850
31MP0003941_abnormal_skin_development1.73792936
32MP0002396_abnormal_hematopoietic_system1.67062789
33MP0002277_abnormal_respiratory_mucosa1.63834010
34MP0010030_abnormal_orbit_morphology1.61978302
35MP0001835_abnormal_antigen_presentation1.61292170
36MP0003186_abnormal_redox_activity1.55860112
37MP0002653_abnormal_ependyma_morphology1.52354502
38MP0009333_abnormal_splenocyte_physiolog1.50656686
39MP0000313_abnormal_cell_death1.49268032
40MP0001661_extended_life_span1.46758694
41MP0005380_embryogenesis_phenotype1.44296059
42MP0001672_abnormal_embryogenesis/_devel1.44296059
43MP0001293_anophthalmia1.42054281
44MP0005394_taste/olfaction_phenotype1.40462291
45MP0005499_abnormal_olfactory_system1.40462291
46MP0001697_abnormal_embryo_size1.39151743
47MP0002085_abnormal_embryonic_tissue1.35946721
48MP0003136_yellow_coat_color1.34763660
49MP0003718_maternal_effect1.32972525
50MP0005075_abnormal_melanosome_morpholog1.31824398
51MP0002080_prenatal_lethality1.30974880
52MP0003315_abnormal_perineum_morphology1.28565834
53MP0002019_abnormal_tumor_incidence1.28014353
54MP0005076_abnormal_cell_differentiation1.24833300
55MP0005266_abnormal_metabolism1.24444234
56MP0001727_abnormal_embryo_implantation1.22172683
57MP0000703_abnormal_thymus_morphology1.20545503
58MP0008789_abnormal_olfactory_epithelium1.19645440
59MP0003984_embryonic_growth_retardation1.16410849
60MP0008877_abnormal_DNA_methylation1.15456880
61MP0002088_abnormal_embryonic_growth/wei1.13192147
62MP0002084_abnormal_developmental_patter1.11464681
63MP0002210_abnormal_sex_determination1.10814575
64MP0005174_abnormal_tail_pigmentation1.09054478
65MP0002111_abnormal_tail_morphology1.08371500
66MP0002398_abnormal_bone_marrow1.07557496
67MP0000689_abnormal_spleen_morphology1.07203560
68MP0001790_abnormal_immune_system1.03610566
69MP0005387_immune_system_phenotype1.03610566
70MP0002877_abnormal_melanocyte_morpholog1.02999896
71MP0003283_abnormal_digestive_organ1.02223605
72MP0002722_abnormal_immune_system1.01278328
73MP0002086_abnormal_extraembryonic_tissu0.99897125
74MP0004808_abnormal_hematopoietic_stem0.98613693
75MP0003121_genomic_imprinting0.97087677
76MP0001145_abnormal_male_reproductive0.95666221
77MP0002138_abnormal_hepatobiliary_system0.95484015
78MP0005220_abnormal_exocrine_pancreas0.95143914
79MP0000049_abnormal_middle_ear0.94672217
80MP0002160_abnormal_reproductive_system0.93630967
81MP0006036_abnormal_mitochondrial_physio0.93357634
82MP0003705_abnormal_hypodermis_morpholog0.93343930
83MP0001188_hyperpigmentation0.92782191
84MP0004197_abnormal_fetal_growth/weight/0.89874533
85MP0004185_abnormal_adipocyte_glucose0.87153811
86MP0002249_abnormal_larynx_morphology0.86642423
87MP0002429_abnormal_blood_cell0.86398237
88MP0010307_abnormal_tumor_latency0.86277025
89MP0002132_abnormal_respiratory_system0.85557682
90MP0002697_abnormal_eye_size0.84572987
91MP0002452_abnormal_antigen_presenting0.83126704
92MP0003567_abnormal_fetal_cardiomyocyte0.83112278
93MP0005000_abnormal_immune_tolerance0.82878785
94MP0006035_abnormal_mitochondrial_morpho0.82854773
95MP0005621_abnormal_cell_physiology0.81935047
96MP0001119_abnormal_female_reproductive0.81619012
97MP0001819_abnormal_immune_cell0.79830240
98MP0005367_renal/urinary_system_phenotyp0.79054246
99MP0000516_abnormal_urinary_system0.79054246
100MP0005384_cellular_phenotype0.78523828
101MP0000569_abnormal_digit_pigmentation0.77871013
102MP0005310_abnormal_salivary_gland0.77599556
103MP0002751_abnormal_autonomic_nervous0.77292213
104MP0000653_abnormal_sex_gland0.75096309
105MP0005623_abnormal_meninges_morphology0.74341741
106MP0000358_abnormal_cell_content/0.74333635
107MP0000716_abnormal_immune_system0.71304115
108MP0001849_ear_inflammation0.70994254
109MP0002254_reproductive_system_inflammat0.69684029
110MP0005389_reproductive_system_phenotype0.69650842
111MP0001929_abnormal_gametogenesis0.69340146
112MP0001191_abnormal_skin_condition0.68983984
113MP0000477_abnormal_intestine_morphology0.68446106
114MP0005647_abnormal_sex_gland0.68116507
115MP0002006_tumorigenesis0.67680065
116MP0001545_abnormal_hematopoietic_system0.66930353
117MP0005397_hematopoietic_system_phenotyp0.66930353
118MP0009931_abnormal_skin_appearance0.65511629
119MP0003936_abnormal_reproductive_system0.65477930
120MP0000858_altered_metastatic_potential0.65393215
121MP0005671_abnormal_response_to0.65305111
122MP0002723_abnormal_immune_serum0.63751255
123MP0005501_abnormal_skin_physiology0.63742374
124MP0003950_abnormal_plasma_membrane0.63324998
125MP0002092_abnormal_eye_morphology0.63006575
126MP0000428_abnormal_craniofacial_morphol0.62884488
127MP0001286_abnormal_eye_development0.62432789
128MP0009046_muscle_twitch0.62390137
129MP0002060_abnormal_skin_morphology0.62239995
130MP0006072_abnormal_retinal_apoptosis0.61985359
131MP0010678_abnormal_skin_adnexa0.61889698
132MP0000537_abnormal_urethra_morphology0.61339456
133MP0000372_irregular_coat_pigmentation0.60696561
134MP0001529_abnormal_vocalization0.60195511
135MP0009053_abnormal_anal_canal0.59624824
136MP0002932_abnormal_joint_morphology0.59476985
137MP0004147_increased_porphyrin_level0.59310872
138MP0001915_intracranial_hemorrhage0.58797454
139MP0003453_abnormal_keratinocyte_physiol0.58565979
140MP0002638_abnormal_pupillary_reflex0.57691412
141MP0004381_abnormal_hair_follicle0.56977494
142MP0003699_abnormal_female_reproductive0.56855462
143MP0000470_abnormal_stomach_morphology0.56541252
144MP0004947_skin_inflammation0.55671386
145MP0002405_respiratory_system_inflammati0.55159044
146MP0001800_abnormal_humoral_immune0.54356014
147MP0001348_abnormal_lacrimal_gland0.53264349
148MP0002420_abnormal_adaptive_immunity0.52571309
149MP0001919_abnormal_reproductive_system0.52534408

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.24857344
2Chromsome breakage (HP:0040012)5.61192738
3IgA deficiency (HP:0002720)5.58281096
4Birth length less than 3rd percentile (HP:0003561)5.36998281
5Colitis (HP:0002583)4.45347500
6Breast hypoplasia (HP:0003187)4.14083748
7Degeneration of anterior horn cells (HP:0002398)4.11855887
8Abnormality of the anterior horn cell (HP:0006802)4.11855887
9Gastrointestinal stroma tumor (HP:0100723)4.10029161
10Abnormality of chromosome stability (HP:0003220)3.95389131
11Reticulocytopenia (HP:0001896)3.94769371
12Carpal bone hypoplasia (HP:0001498)3.87853157
13Abnormality of cells of the erythroid lineage (HP:0012130)3.85521755
14Agammaglobulinemia (HP:0004432)3.76587851
15Rectal fistula (HP:0100590)3.71259270
16Rectovaginal fistula (HP:0000143)3.71259270
17Stenosis of the external auditory canal (HP:0000402)3.71215870
18Aplasia/Hypoplasia of the sacrum (HP:0008517)3.50687492
19Selective tooth agenesis (HP:0001592)3.50200593
20Cellulitis (HP:0100658)3.48993992
21Absent thumb (HP:0009777)3.47482607
22Colon cancer (HP:0003003)3.46305159
23Recurrent sinusitis (HP:0011108)3.45883893
24Multiple enchondromatosis (HP:0005701)3.43455173
25Abnormality of abdominal situs (HP:0011620)3.41350365
26Abdominal situs inversus (HP:0003363)3.41350365
27Macrocytic anemia (HP:0001972)3.34459950
28Abnormal number of erythroid precursors (HP:0012131)3.32506967
29Oral leukoplakia (HP:0002745)3.27477156
30Vaginal fistula (HP:0004320)3.27452381
31Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.27012563
32Patellar aplasia (HP:0006443)3.24313279
33Squamous cell carcinoma (HP:0002860)3.22852523
34Intestinal fistula (HP:0100819)3.19188373
35B lymphocytopenia (HP:0010976)3.15157518
36Absent radius (HP:0003974)3.13679147
37Aplasia/Hypoplasia of the patella (HP:0006498)3.02369046
38Microretrognathia (HP:0000308)3.00610028
39Nephroblastoma (Wilms tumor) (HP:0002667)3.00420540
40Impulsivity (HP:0100710)2.99952525
41Lymphopenia (HP:0001888)2.95600247
42Abnormal number of incisors (HP:0011064)2.95382212
43Abnormality of cells of the lymphoid lineage (HP:0012140)2.93364335
44Abnormality of the carotid arteries (HP:0005344)2.91385091
45Absent forearm bone (HP:0003953)2.90971769
46Aplasia involving forearm bones (HP:0009822)2.90971769
47Poikilocytosis (HP:0004447)2.89920497
48Ependymoma (HP:0002888)2.82345687
49Embryonal renal neoplasm (HP:0011794)2.80164808
50Clubbing of toes (HP:0100760)2.77424515
51Abnormal hemoglobin (HP:0011902)2.75582148
52Small intestinal stenosis (HP:0012848)2.75210914
53Duodenal stenosis (HP:0100867)2.75210914
54Pallor (HP:0000980)2.74931757
55Aplasia/hypoplasia of the humerus (HP:0006507)2.73101399
56Rib fusion (HP:0000902)2.72565369
57Recurrent bronchitis (HP:0002837)2.67267803
58Trismus (HP:0000211)2.65266696
59Prostate neoplasm (HP:0100787)2.62377643
60Abnormality of B cell number (HP:0010975)2.61765912
61Septo-optic dysplasia (HP:0100842)2.58783413
62Medulloblastoma (HP:0002885)2.58643976
63Atrophy/Degeneration involving motor neurons (HP:0007373)2.58209591
64Inflammation of the large intestine (HP:0002037)2.57213191
65Progressive external ophthalmoplegia (HP:0000590)2.52812878
66Asplenia (HP:0001746)2.52426635
67Myelodysplasia (HP:0002863)2.51342277
68Rough bone trabeculation (HP:0100670)2.51104813
69Microvesicular hepatic steatosis (HP:0001414)2.49690100
70Aplastic anemia (HP:0001915)2.49081359
71Hypoplasia of the radius (HP:0002984)2.48956360
72Premature graying of hair (HP:0002216)2.46524895
73Dry hair (HP:0011359)2.45603972
74Cleft eyelid (HP:0000625)2.42709198
75Gastrointestinal inflammation (HP:0004386)2.38096432
76Basal cell carcinoma (HP:0002671)2.35430688
77Agnosia (HP:0010524)2.34171107
78Glossoptosis (HP:0000162)2.34170587
79Abnormality of the duodenum (HP:0002246)2.32602059
80Leukopenia (HP:0001882)2.31242828
81Missing ribs (HP:0000921)2.30954563
82Cafe-au-lait spot (HP:0000957)2.29417418
83Recurrent viral infections (HP:0004429)2.28626185
84Thyroiditis (HP:0100646)2.27996623
85Triphalangeal thumb (HP:0001199)2.27641454
86Short humerus (HP:0005792)2.27176605
87Insomnia (HP:0100785)2.26891887
88Aplasia/Hypoplasia of the spleen (HP:0010451)2.25494325
89Horseshoe kidney (HP:0000085)2.25304845
90Onycholysis (HP:0001806)2.22422627
91Atresia of the external auditory canal (HP:0000413)2.20618316
92Type I transferrin isoform profile (HP:0003642)2.20136817
93Acute necrotizing encephalopathy (HP:0006965)2.19612165
94Abnormality of the prostate (HP:0008775)2.19093364
95Osteomyelitis (HP:0002754)2.18345825
96Autoimmune hemolytic anemia (HP:0001890)2.16652541
97Supernumerary spleens (HP:0009799)2.14061596
98Abnormality of DNA repair (HP:0003254)2.11861939
99Abnormality of the fingertips (HP:0001211)2.10976092
100Sex reversal (HP:0012245)2.10732682
101Abnormal sex determination (HP:0012244)2.10732682
102Chronic diarrhea (HP:0002028)2.10700912
103Abnormality of the ileum (HP:0001549)2.09327508
104Megaloblastic anemia (HP:0001889)2.07656371
105Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07270732
106Meckel diverticulum (HP:0002245)2.07193065
107Meningitis (HP:0001287)2.07186218
108Dysphonia (HP:0001618)2.06777013
109Tracheoesophageal fistula (HP:0002575)2.06638147
110Acanthocytosis (HP:0001927)2.03595364
111Lymphoma (HP:0002665)2.02729588
112Short 4th metacarpal (HP:0010044)2.02597357
113Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.02597357
114Combined immunodeficiency (HP:0005387)2.01997191
115Erythema (HP:0010783)2.01613570
116Arteriovenous malformation (HP:0100026)2.00956936
117Congenital malformation of the right heart (HP:0011723)2.00451862
118Double outlet right ventricle (HP:0001719)2.00451862
119Prominent nose (HP:0000448)1.99929122
120Testicular atrophy (HP:0000029)1.99064429
121Severe combined immunodeficiency (HP:0004430)1.97426587
122Abnormal mitochondria in muscle tissue (HP:0008316)1.96870703
123Recurrent pneumonia (HP:0006532)1.96435556
124Optic nerve coloboma (HP:0000588)1.96343199
125Viral hepatitis (HP:0006562)1.96020016
126Sandal gap (HP:0001852)1.95296646
1273-Methylglutaconic aciduria (HP:0003535)1.95118979
128Ridged nail (HP:0001807)1.94109412
129Increased serum lactate (HP:0002151)1.93795351
130Abnormality of reticulocytes (HP:0004312)1.93374432
131Abnormality of the preputium (HP:0100587)1.92862951
132Poikiloderma (HP:0001029)1.92624929
133External ophthalmoplegia (HP:0000544)1.92283819
134Neoplasm of the pancreas (HP:0002894)1.91893635
135Abnormality of pyrimidine metabolism (HP:0004353)1.90925418
136Cellular immunodeficiency (HP:0005374)1.90666633
137Aplasia/Hypoplasia of the uvula (HP:0010293)1.89888274
138Acute lymphatic leukemia (HP:0006721)1.89824373
139Sloping forehead (HP:0000340)1.89558825
140Hepatitis (HP:0012115)1.88300349
141Skull defect (HP:0001362)1.87483679
14211 pairs of ribs (HP:0000878)1.86073395
143Spinal muscular atrophy (HP:0007269)1.85626291
144Progressive muscle weakness (HP:0003323)1.85576174
145Asymmetry of the thorax (HP:0001555)1.85369958
146Orthostatic hypotension (HP:0001278)1.84978606
147Renovascular hypertension (HP:0100817)1.84863036
148Recurrent lower respiratory tract infections (HP:0002783)1.84386206
149Neoplasm of striated muscle (HP:0009728)1.83776270
150IgM deficiency (HP:0002850)1.83564178
151IgG deficiency (HP:0004315)1.83110570
152Severe visual impairment (HP:0001141)1.82287806
153Deep philtrum (HP:0002002)1.82213263
154Pancytopenia (HP:0001876)1.82056131
155Bone marrow hypocellularity (HP:0005528)1.81004499
156Entropion (HP:0000621)1.80031843
157Intestinal atresia (HP:0011100)1.79997106
158Facial cleft (HP:0002006)1.79791051
159Aplasia/Hypoplasia involving the musculature (HP:0001460)1.79486836
160Short thumb (HP:0009778)1.79342618
161Hepatocellular necrosis (HP:0001404)1.78922247
162Acute encephalopathy (HP:0006846)1.78462542
163Rhabdomyosarcoma (HP:0002859)1.78420339
164Panhypogammaglobulinemia (HP:0003139)1.75722383
165Optic nerve hypoplasia (HP:0000609)1.75527776
166Partial duplication of thumb phalanx (HP:0009944)1.74688737
167Fused cervical vertebrae (HP:0002949)1.74150849
168Maternal diabetes (HP:0009800)1.73925137
169Hyperacusis (HP:0010780)1.72445682
170Embryonal neoplasm (HP:0002898)1.72092024
171Abnormality of the renal collecting system (HP:0004742)1.69920380
172Spastic diplegia (HP:0001264)1.69038596
173Ovarian neoplasm (HP:0100615)1.68028227
174Abnormality of the heme biosynthetic pathway (HP:0010472)1.67779493
175Duplicated collecting system (HP:0000081)1.67709507
176Hypergonadotropic hypogonadism (HP:0000815)1.67015010
177Malignant gastrointestinal tract tumors (HP:0006749)1.66907826
178Gastrointestinal carcinoma (HP:0002672)1.66907826

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.33494889
2WEE14.23306640
3BUB13.62689899
4NME23.48263536
5VRK13.11941443
6TESK22.85234472
7DAPK32.76887321
8PLK42.74757788
9SRPK12.57599724
10EIF2AK12.50568719
11DYRK32.28028895
12ACVR1B2.24966861
13NEK22.14745724
14MAP4K12.14478848
15MKNK12.06292751
16CDK72.03358508
17MAP3K111.90913600
18EIF2AK31.88261027
19PLK11.81655661
20TLK11.75756228
21BRSK21.68782505
22TTK1.54520021
23KDR1.51774977
24DYRK21.51376813
25SMG11.43292210
26WNK41.41025790
27MAP3K81.39207592
28AURKA1.37729298
29AURKB1.36880236
30STK101.36068660
31STK391.32062717
32PASK1.30913960
33ATR1.26655079
34TAF11.26568161
35STK161.25561226
36CHEK21.24019383
37PLK31.23416821
38GRK61.22685711
39BRSK11.18391217
40EIF2AK21.17888219
41STK41.17621523
42PKN11.15127815
43EEF2K1.12658335
44RPS6KB21.09760314
45MKNK21.03573115
46TGFBR11.03554416
47TESK11.03471956
48UHMK11.03397579
49PIM21.01596682
50CDK81.00832814
51BCKDK0.98657070
52LRRK20.97913998
53NEK10.93466086
54MAPKAPK30.89593246
55PINK10.81320462
56DAPK10.81077623
57CHEK10.80274422
58BLK0.78646829
59LATS20.78258668
60PIM10.78116471
61BRAF0.77788216
62SCYL20.76828592
63CSNK2A10.76766603
64TAOK20.76221348
65MAP2K60.72476770
66ICK0.68281292
67MST40.67866643
68CDK190.67567494
69DYRK1B0.67043385
70PAK10.66444407
71CDK120.66028484
72CSNK2A20.62580510
73CDK40.62459923
74PRKCI0.61678009
75PRPF4B0.61042169
76CDK20.59792457
77YES10.56842142
78ABL20.54035999
79PAK40.53706506
80MELK0.53074638
81AKT20.52807329
82LIMK10.51561078
83PRKAA10.50526528
84RPS6KA40.50452412
85TSSK60.49619301
86ATM0.49482607
87CCNB10.47535797
88ARAF0.44924745
89FLT30.44299098
90NEK90.43490705
91SYK0.43383605
92NME10.43060643
93LYN0.42445391
94ZAK0.41894394
95TYK20.39638938
96MAP3K100.39270409
97ADRBK20.39208289
98PRKCQ0.37442891
99ZAP700.36784254
100IRAK40.34952297
101CDK10.34661806
102EPHA20.33384045
103MAPK110.33275562
104LCK0.32962012
105RPS6KA50.32142960
106JAK20.31040131
107IKBKB0.30414087
108CDK60.30309504
109PBK0.29945155
110CHUK0.29844975
111BTK0.28258412
112TNIK0.25414369
113TEC0.25066345
114MATK0.24493213
115VRK20.18880222
116CAMK40.18487569
117TTN0.17359080
118IKBKE0.17114707
119BRD40.16795414
120RAF10.16443208
121PIK3CG0.14317441
122STK30.14176073
123CDK90.13599662
124MAP3K140.12639195
125TRPM70.11223489
126CLK10.10206494
127CSNK1G10.09955923
128CSF1R0.09816517
129TBK10.09464829
130MAP3K40.09428003
131PRKCD0.09137047
132PRKDC0.08678420
133RPS6KB10.08659243
134NLK0.08539137
135RPS6KA30.07986370
136SGK10.07723314
137AKT10.06823687
138MAP2K70.06470733
139MAPK140.06334550

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.72659028
2Ribosome_Homo sapiens_hsa030105.20176076
3Mismatch repair_Homo sapiens_hsa034304.89479797
4RNA polymerase_Homo sapiens_hsa030203.53549906
5Spliceosome_Homo sapiens_hsa030403.38791658
6Base excision repair_Homo sapiens_hsa034103.27294441
7Homologous recombination_Homo sapiens_hsa034403.12100788
8Proteasome_Homo sapiens_hsa030503.02154406
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.93180879
10Pyrimidine metabolism_Homo sapiens_hsa002402.92928733
11Nucleotide excision repair_Homo sapiens_hsa034202.83073080
12One carbon pool by folate_Homo sapiens_hsa006702.52654922
13RNA transport_Homo sapiens_hsa030132.43360708
14Cell cycle_Homo sapiens_hsa041102.18698287
15Fanconi anemia pathway_Homo sapiens_hsa034602.02385635
16Non-homologous end-joining_Homo sapiens_hsa034501.83979178
17p53 signaling pathway_Homo sapiens_hsa041151.61048309
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60965764
19RNA degradation_Homo sapiens_hsa030181.46965915
20Sulfur relay system_Homo sapiens_hsa041221.45887404
21Purine metabolism_Homo sapiens_hsa002301.45517822
22Folate biosynthesis_Homo sapiens_hsa007901.37126013
23Basal transcription factors_Homo sapiens_hsa030221.28768279
24mRNA surveillance pathway_Homo sapiens_hsa030151.25441888
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25438505
26Parkinsons disease_Homo sapiens_hsa050121.19297710
27Oxidative phosphorylation_Homo sapiens_hsa001901.17038064
28Huntingtons disease_Homo sapiens_hsa050161.16476560
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.07834200
30Protein export_Homo sapiens_hsa030601.05200476
31Asthma_Homo sapiens_hsa053101.00693083
32Primary immunodeficiency_Homo sapiens_hsa053401.00571194
33Autoimmune thyroid disease_Homo sapiens_hsa053200.99613847
34* Systemic lupus erythematosus_Homo sapiens_hsa053220.98573738
35Cyanoamino acid metabolism_Homo sapiens_hsa004600.96758869
36Biosynthesis of amino acids_Homo sapiens_hsa012300.95177280
37Pentose phosphate pathway_Homo sapiens_hsa000300.92534043
38Epstein-Barr virus infection_Homo sapiens_hsa051690.86351169
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81174463
40Oocyte meiosis_Homo sapiens_hsa041140.79023184
41B cell receptor signaling pathway_Homo sapiens_hsa046620.78543508
42Thyroid cancer_Homo sapiens_hsa052160.76972446
43Herpes simplex infection_Homo sapiens_hsa051680.76534828
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.74321663
45Glutathione metabolism_Homo sapiens_hsa004800.74313743
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72293270
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70940408
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70252382
49Type I diabetes mellitus_Homo sapiens_hsa049400.69922752
50Selenocompound metabolism_Homo sapiens_hsa004500.68531591
51Alzheimers disease_Homo sapiens_hsa050100.58494394
52Viral carcinogenesis_Homo sapiens_hsa052030.57001844
53Carbon metabolism_Homo sapiens_hsa012000.56904794
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55049662
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53821676
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52718836
57Vitamin B6 metabolism_Homo sapiens_hsa007500.50702905
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50441903
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48939562
60Non-small cell lung cancer_Homo sapiens_hsa052230.46032219
61HTLV-I infection_Homo sapiens_hsa051660.43781884
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43497778
63Antigen processing and presentation_Homo sapiens_hsa046120.42728754
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40672837
65Shigellosis_Homo sapiens_hsa051310.40274267
66Chronic myeloid leukemia_Homo sapiens_hsa052200.39615285
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39114219
68Metabolic pathways_Homo sapiens_hsa011000.38776201
69Pancreatic cancer_Homo sapiens_hsa052120.36405189
70Bladder cancer_Homo sapiens_hsa052190.35442280
71N-Glycan biosynthesis_Homo sapiens_hsa005100.35312008
72TGF-beta signaling pathway_Homo sapiens_hsa043500.34564576
73* Alcoholism_Homo sapiens_hsa050340.34266647
74Leishmaniasis_Homo sapiens_hsa051400.34088998
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.33065861
76Hippo signaling pathway_Homo sapiens_hsa043900.32813325
77Basal cell carcinoma_Homo sapiens_hsa052170.31428712
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31385427
79Arginine and proline metabolism_Homo sapiens_hsa003300.30708441
80Influenza A_Homo sapiens_hsa051640.30525633
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30383876
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30316333
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29682521
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29614204
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.29515615
86Measles_Homo sapiens_hsa051620.28745524
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28412897
88Glioma_Homo sapiens_hsa052140.27080647
89Lysine degradation_Homo sapiens_hsa003100.24384338
90Fructose and mannose metabolism_Homo sapiens_hsa000510.23806130
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23616205
92Arachidonic acid metabolism_Homo sapiens_hsa005900.23389946
93Hedgehog signaling pathway_Homo sapiens_hsa043400.20638245
94Cardiac muscle contraction_Homo sapiens_hsa042600.20470207
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19224407
96Prostate cancer_Homo sapiens_hsa052150.18161466
97Galactose metabolism_Homo sapiens_hsa000520.17763565
98Inositol phosphate metabolism_Homo sapiens_hsa005620.16343286
99Viral myocarditis_Homo sapiens_hsa054160.15859254
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.15777260
101Legionellosis_Homo sapiens_hsa051340.13652376
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.13378654
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.12806483
104MicroRNAs in cancer_Homo sapiens_hsa052060.12283074
105Toxoplasmosis_Homo sapiens_hsa051450.11833850
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.11829117
107Wnt signaling pathway_Homo sapiens_hsa043100.11534309
108Hepatitis B_Homo sapiens_hsa051610.11139974
109HIF-1 signaling pathway_Homo sapiens_hsa040660.11057376
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.09868859
111Allograft rejection_Homo sapiens_hsa053300.09227644
112Small cell lung cancer_Homo sapiens_hsa052220.09046403
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.08468385
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.08401883
115Acute myeloid leukemia_Homo sapiens_hsa052210.08277542
116Renin-angiotensin system_Homo sapiens_hsa046140.07963576
117Endometrial cancer_Homo sapiens_hsa052130.07362043
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.06616516
119Pyruvate metabolism_Homo sapiens_hsa006200.06401401
120Apoptosis_Homo sapiens_hsa042100.06098263
121Hematopoietic cell lineage_Homo sapiens_hsa046400.05749840
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.04928952
123Colorectal cancer_Homo sapiens_hsa052100.04656203
124Pathways in cancer_Homo sapiens_hsa052000.04618981
125Melanoma_Homo sapiens_hsa052180.04529174
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.03738904
127Graft-versus-host disease_Homo sapiens_hsa053320.03592279
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.02574075
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.01712420
130Proteoglycans in cancer_Homo sapiens_hsa052050.01214289
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.01046413

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