HIST1H2AK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)8.98858213
2protoporphyrinogen IX biosynthetic process (GO:0006782)8.08286649
3DNA replication-dependent nucleosome organization (GO:0034723)7.73506555
4DNA replication-dependent nucleosome assembly (GO:0006335)7.73506555
5chromatin assembly (GO:0031497)7.53509615
6nucleosome assembly (GO:0006334)7.53141045
7nucleosome organization (GO:0034728)6.65112007
8antibacterial humoral response (GO:0019731)6.56318414
9protein-DNA complex assembly (GO:0065004)6.36938332
10innate immune response in mucosa (GO:0002227)6.29000384
11antimicrobial humoral response (GO:0019730)6.14499736
12regulation of histone H3-K9 methylation (GO:0051570)6.06595898
13porphyrin-containing compound biosynthetic process (GO:0006779)6.01839253
14protein-DNA complex subunit organization (GO:0071824)5.81677263
15erythrocyte maturation (GO:0043249)5.81322635
16mitotic chromosome condensation (GO:0007076)5.56689304
17chromatin assembly or disassembly (GO:0006333)5.54230131
18sister chromatid segregation (GO:0000819)5.34675470
19tetrapyrrole biosynthetic process (GO:0033014)5.26463183
20negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)5.23663144
21heme biosynthetic process (GO:0006783)5.17050625
22mitotic sister chromatid segregation (GO:0000070)5.07145027
23protein localization to kinetochore (GO:0034501)5.03199652
24regulation of DNA endoreduplication (GO:0032875)5.02337043
25DNA unwinding involved in DNA replication (GO:0006268)4.99218094
26DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.93294450
27hemoglobin metabolic process (GO:0020027)4.89816411
28regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.86697364
29mucosal immune response (GO:0002385)4.84994749
30kinetochore organization (GO:0051383)4.71274178
31microtubule depolymerization (GO:0007019)4.70646284
32protein localization to chromosome, centromeric region (GO:0071459)4.68363958
33defense response to Gram-positive bacterium (GO:0050830)4.68166085
34organ or tissue specific immune response (GO:0002251)4.58232523
35nuclear pore organization (GO:0006999)4.57505066
36nuclear pore complex assembly (GO:0051292)4.55186637
37erythrocyte development (GO:0048821)4.44166070
38porphyrin-containing compound metabolic process (GO:0006778)4.42485848
39DNA damage response, signal transduction resulting in transcription (GO:0042772)4.40309564
40positive regulation of mitotic sister chromatid separation (GO:1901970)4.31466714
41positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.31466714
42positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.31466714
43negative regulation of B cell apoptotic process (GO:0002903)4.16319508
44regulation of response to osmotic stress (GO:0047484)4.09796896
45regulation of centriole replication (GO:0046599)4.02726719
46attachment of spindle microtubules to kinetochore (GO:0008608)4.01590287
47positive regulation of chromosome segregation (GO:0051984)3.98255254
48B cell receptor signaling pathway (GO:0050853)3.98172500
49regulation of megakaryocyte differentiation (GO:0045652)3.96769981
50mitotic sister chromatid cohesion (GO:0007064)3.93958495
51regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.90471321
52meiotic chromosome segregation (GO:0045132)3.85899732
53CENP-A containing nucleosome assembly (GO:0034080)3.85250227
54DNA replication initiation (GO:0006270)3.82762556
55chromatin remodeling at centromere (GO:0031055)3.81260839
56response to methylmercury (GO:0051597)3.79450624
57regulation of sister chromatid cohesion (GO:0007063)3.74473594
58heme metabolic process (GO:0042168)3.71866007
59negative regulation of histone methylation (GO:0031061)3.71584084
60viral mRNA export from host cell nucleus (GO:0046784)3.69011446
61chromosome condensation (GO:0030261)3.68627297
62protein K6-linked ubiquitination (GO:0085020)3.68102232
63kinetochore assembly (GO:0051382)3.66303122
64DNA replication-independent nucleosome organization (GO:0034724)3.65166457
65DNA replication-independent nucleosome assembly (GO:0006336)3.65166457
66immunoglobulin mediated immune response (GO:0016064)3.58370271
67regulation of centrosome cycle (GO:0046605)3.55893173
68regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.53248424
69DNA strand elongation involved in DNA replication (GO:0006271)3.50407893
70dosage compensation (GO:0007549)3.48089803
71protein-DNA complex disassembly (GO:0032986)3.47073461
72nucleosome disassembly (GO:0006337)3.47073461
73mitotic nuclear envelope disassembly (GO:0007077)3.46722494
74protein localization to chromosome (GO:0034502)3.41395620
75pre-miRNA processing (GO:0031054)3.41128592
76response to insecticide (GO:0017085)3.39341358
77maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.38133464
78regulation of centrosome duplication (GO:0010824)3.37890946
79pore complex assembly (GO:0046931)3.37268457
80mitotic recombination (GO:0006312)3.35425597
81DNA strand elongation (GO:0022616)3.35010664
82regulation of B cell apoptotic process (GO:0002902)3.33809404
83chromosome segregation (GO:0007059)3.33801372
84telomere maintenance via semi-conservative replication (GO:0032201)3.33751438
85DNA geometric change (GO:0032392)3.30448753
86DNA duplex unwinding (GO:0032508)3.30432416
87translesion synthesis (GO:0019985)3.30091313
88erythrocyte differentiation (GO:0030218)3.29742798
89regulation of gene silencing (GO:0060968)3.28834261
90nucleotide-excision repair, DNA gap filling (GO:0006297)3.27538584
91nuclear envelope disassembly (GO:0051081)3.26911302
92membrane disassembly (GO:0030397)3.26911302
93rRNA transcription (GO:0009303)3.26837701
94DNA replication checkpoint (GO:0000076)3.26399942
95histone exchange (GO:0043486)3.25606884
96regulation of spindle organization (GO:0090224)3.24668682
97metaphase plate congression (GO:0051310)3.23530028
98response to lead ion (GO:0010288)3.20545647
99mitotic metaphase plate congression (GO:0007080)3.20230143
100DNA packaging (GO:0006323)3.19636608
101peptidyl-arginine omega-N-methylation (GO:0035247)3.18608092
102DNA synthesis involved in DNA repair (GO:0000731)3.17424011
103DNA topological change (GO:0006265)3.12676519
104regulation of chromosome segregation (GO:0051983)3.12191867
105postreplication repair (GO:0006301)3.11721409
106heterochromatin organization (GO:0070828)3.09680475
107B cell mediated immunity (GO:0019724)3.05594088
108replication fork processing (GO:0031297)3.05343640
109establishment of chromosome localization (GO:0051303)3.04748323
110telomere maintenance via recombination (GO:0000722)3.03133151
111proline biosynthetic process (GO:0006561)3.02918485
112positive regulation of histone methylation (GO:0031062)3.02910172
113regulation of mitotic metaphase/anaphase transition (GO:0030071)3.02708696
114ATP-dependent chromatin remodeling (GO:0043044)3.02229804
115regulation of translational fidelity (GO:0006450)3.01243137
116DNA conformation change (GO:0071103)3.00186990
117telomere organization (GO:0032200)2.87847832
118telomere maintenance (GO:0000723)2.84162254
119telomere maintenance via telomere lengthening (GO:0010833)2.82665707
120mitochondrial DNA metabolic process (GO:0032042)2.78668254
121deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.73434381
122replicative senescence (GO:0090399)2.71253291
123chaperone mediated protein folding requiring cofactor (GO:0051085)2.69252966
124mature B cell differentiation involved in immune response (GO:0002313)2.68311928
125regulation of mitochondrial translation (GO:0070129)2.66032522
126somatic hypermutation of immunoglobulin genes (GO:0016446)2.64730419
127somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64730419
128V(D)J recombination (GO:0033151)2.63218996
129regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.62291166
130mitochondrial RNA metabolic process (GO:0000959)2.60510883
131pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.59071814
132peptidyl-arginine methylation (GO:0018216)2.54921392
133peptidyl-arginine N-methylation (GO:0035246)2.54921392
134histone arginine methylation (GO:0034969)2.54429549
135humoral immune response (GO:0006959)2.51594606
136positive regulation of alpha-beta T cell proliferation (GO:0046641)2.50348004
137regulation of mammary gland epithelial cell proliferation (GO:0033599)2.50064202
138B cell proliferation (GO:0042100)2.47410215
139cellular response to UV (GO:0034644)2.46454489
140mitochondrial fusion (GO:0008053)2.43918948
141positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.40674440
142T-helper 1 type immune response (GO:0042088)2.37871160
143negative regulation of lymphocyte apoptotic process (GO:0070229)2.37522506
144DNA deamination (GO:0045006)2.35259901
145tongue development (GO:0043586)2.33644819
146somatic cell DNA recombination (GO:0016444)2.31686125
147somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.31686125
148peptidyl-lysine dimethylation (GO:0018027)2.30768688
149positive thymic T cell selection (GO:0045059)2.30186119
150regulation of spindle checkpoint (GO:0090231)2.29831529
151negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.29219950

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.74739496
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.91850520
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.67634428
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.41636946
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08617568
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.88143443
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.84536507
8* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.79118466
9TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.40867388
10SOX2_16153702_ChIP-ChIP_HESCs_Human2.40429659
11MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.38107032
12* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.30778505
13* E2F1_21310950_ChIP-Seq_MCF-7_Human2.25146986
14* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.16266869
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse13.9997149
16* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.87070788
17HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.83408229
18CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.83035916
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.74676596
20POU5F1_16153702_ChIP-ChIP_HESCs_Human1.72786566
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72511546
22AR_21909140_ChIP-Seq_LNCAP_Human1.70498144
23GATA1_22025678_ChIP-Seq_K562_Human1.68932327
24* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68069362
25IRF1_19129219_ChIP-ChIP_H3396_Human1.59745498
26SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.55503523
27SOX2_18555785_ChIP-Seq_MESCs_Mouse1.48023327
28* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46659949
29ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44674662
30* GATA1_19941826_ChIP-Seq_K562_Human1.44193726
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.42510331
32MYC_22102868_ChIP-Seq_BL_Human1.39967551
33HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.39102321
34ESR1_15608294_ChIP-ChIP_MCF-7_Human1.38861010
35* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.37081974
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.35707648
37* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30425847
38* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25071303
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24600577
40POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23831046
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22100730
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22046078
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20843798
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19260068
45NANOG_16153702_ChIP-ChIP_HESCs_Human1.15895604
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14572702
47DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14270224
48SCL_19346495_ChIP-Seq_HPC-7_Human1.12994875
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11466715
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11449484
51KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.10409830
52* VDR_23849224_ChIP-Seq_CD4+_Human1.09735477
53MYC_18940864_ChIP-ChIP_HL60_Human1.08518307
54VDR_21846776_ChIP-Seq_THP-1_Human1.07967304
55GATA1_19941827_ChIP-Seq_MEL_Mouse1.06882353
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.06649557
57* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.06457364
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06253164
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04491519
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.04402547
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.03349563
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02216284
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00350627
64* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99919607
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97133203
66ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97018666
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96084477
68* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95433082
69GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95353904
70EST1_17652178_ChIP-ChIP_JURKAT_Human0.95128093
71* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94377010
72* THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93628525
73CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92203382
74STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90902677
75* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90490320
76NANOG_18555785_ChIP-Seq_MESCs_Mouse0.89389478
77IRF8_22096565_ChIP-ChIP_GC-B_Human0.86261014
78* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.85870224
79* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.85727783
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85510273
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.85381307
82TP63_19390658_ChIP-ChIP_HaCaT_Human0.83929348
83GATA2_22383799_ChIP-Seq_G1ME_Mouse0.81181451
84DCP1A_22483619_ChIP-Seq_HELA_Human0.81017982
85EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.79782195
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79741832
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.79133974
88PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78978626
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78208963
90NANOG_21062744_ChIP-ChIP_HESCs_Human0.77122293
91MYC_18358816_ChIP-ChIP_MESCs_Mouse0.76062337
92PKCTHETA_26484144_Chip-Seq_BREAST_Human0.75572111
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.75416221
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.74264033
95TCF7_22412390_ChIP-Seq_EML_Mouse0.74229177
96XRN2_22483619_ChIP-Seq_HELA_Human0.74065840
97ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.74057795
98* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.73389189
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.72939810
100* ELK1_19687146_ChIP-ChIP_HELA_Human0.72746988
101MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.71906270
102MYB_26560356_Chip-Seq_TH1_Human0.70538168
103UTX_26944678_Chip-Seq_JUKART_Human0.70096151
104NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.70014116
105CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.69464694
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.69366308
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.69130796
108CIITA_25753668_ChIP-Seq_RAJI_Human0.68739318
109YY1_21170310_ChIP-Seq_MESCs_Mouse0.68563103
110SRF_21415370_ChIP-Seq_HL-1_Mouse0.68509332
111SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.68283691
112* GATA2_19941826_ChIP-Seq_K562_Human0.67386175
113FOXP3_21729870_ChIP-Seq_TREG_Human0.67118791
114MYCN_18555785_ChIP-Seq_MESCs_Mouse0.67008085
115RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.66898689
116GABP_19822575_ChIP-Seq_HepG2_Human0.66521937
117* MAF_26560356_Chip-Seq_TH1_Human0.64776887
118GABP_17652178_ChIP-ChIP_JURKAT_Human0.63324726
119TTF2_22483619_ChIP-Seq_HELA_Human0.62441842
120SALL1_21062744_ChIP-ChIP_HESCs_Human0.61889871
121KDM5A_27292631_Chip-Seq_BREAST_Human0.61357425
122YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.59964892
123POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.59356019
124E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.57790139
125* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.57413491
126FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.57242181
127KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.57084254
128NCOR1_26117541_ChIP-Seq_K562_Human0.57045454
129CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.56828277
130MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.55781421

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo6.23951717
2MP0004147_increased_porphyrin_level5.68798597
3MP0010094_abnormal_chromosome_stability4.48211613
4MP0003111_abnormal_nucleus_morphology4.33767736
5MP0005645_abnormal_hypothalamus_physiol4.00782513
6MP0003077_abnormal_cell_cycle3.65105836
7MP0010307_abnormal_tumor_latency3.28663752
8MP0003693_abnormal_embryo_hatching3.27704444
9MP0008057_abnormal_DNA_replication3.12558410
10MP0001835_abnormal_antigen_presentation2.96128557
11MP0002138_abnormal_hepatobiliary_system2.84967172
12MP0004957_abnormal_blastocyst_morpholog2.73833724
13MP0005076_abnormal_cell_differentiation2.63611459
14MP0010352_gastrointestinal_tract_polyps2.50878506
15MP0003763_abnormal_thymus_physiology2.44492189
16MP0000350_abnormal_cell_proliferation2.19022112
17MP0003123_paternal_imprinting2.18397951
18MP0008058_abnormal_DNA_repair2.15959371
19MP0005083_abnormal_biliary_tract2.13771727
20MP0003705_abnormal_hypodermis_morpholog2.12641164
21MP0001800_abnormal_humoral_immune2.10239686
22MP0001661_extended_life_span2.07811218
23MP0008877_abnormal_DNA_methylation1.98929449
24MP0010030_abnormal_orbit_morphology1.97596457
25MP0003121_genomic_imprinting1.96787349
26MP0001730_embryonic_growth_arrest1.96609742
27MP0005671_abnormal_response_to1.95496758
28MP0002822_catalepsy1.82960570
29MP0002396_abnormal_hematopoietic_system1.82596139
30MP0004808_abnormal_hematopoietic_stem1.81988682
31MP0005220_abnormal_exocrine_pancreas1.81381590
32MP0008932_abnormal_embryonic_tissue1.77029614
33MP0008007_abnormal_cellular_replicative1.69302479
34MP0005397_hematopoietic_system_phenotyp1.67973054
35MP0001545_abnormal_hematopoietic_system1.67973054
36MP0005000_abnormal_immune_tolerance1.66198744
37MP0004197_abnormal_fetal_growth/weight/1.65335175
38MP0002086_abnormal_extraembryonic_tissu1.61471886
39MP0005387_immune_system_phenotype1.60693279
40MP0001790_abnormal_immune_system1.60693279
41MP0001697_abnormal_embryo_size1.60337288
42MP0009697_abnormal_copulation1.59255857
43MP0004185_abnormal_adipocyte_glucose1.59028301
44MP0000490_abnormal_crypts_of1.57151784
45MP0001672_abnormal_embryogenesis/_devel1.56584864
46MP0005380_embryogenesis_phenotype1.56584864
47MP0006054_spinal_hemorrhage1.55502713
48MP0002084_abnormal_developmental_patter1.55160117
49MP0002009_preneoplasia1.49257644
50MP0005464_abnormal_platelet_physiology1.48293306
51MP0002085_abnormal_embryonic_tissue1.46069840
52MP0003984_embryonic_growth_retardation1.42337820
53MP0009053_abnormal_anal_canal1.40784217
54MP0002088_abnormal_embryonic_growth/wei1.39916169
55MP0002080_prenatal_lethality1.38373648
56MP0002019_abnormal_tumor_incidence1.37137173
57MP0008995_early_reproductive_senescence1.35508473
58MP0002452_abnormal_antigen_presenting1.34190302
59MP0002420_abnormal_adaptive_immunity1.34041747
60MP0001727_abnormal_embryo_implantation1.32318768
61MP0000313_abnormal_cell_death1.31850761
62MP0003890_abnormal_embryonic-extraembry1.29176228
63MP0000703_abnormal_thymus_morphology1.28898993
64MP0001819_abnormal_immune_cell1.27539212
65MP0003937_abnormal_limbs/digits/tail_de1.23722672
66MP0002398_abnormal_bone_marrow1.23295737
67MP0002723_abnormal_immune_serum1.23058281
68MP0010234_abnormal_vibrissa_follicle1.22589154
69MP0000465_gastrointestinal_hemorrhage1.22531266
70MP0009046_muscle_twitch1.21282145
71MP0002722_abnormal_immune_system1.19829387
72MP0000013_abnormal_adipose_tissue1.18255997
73MP0003787_abnormal_imprinting1.17944682
74MP0000358_abnormal_cell_content/1.16577776
75MP0002166_altered_tumor_susceptibility1.14176068
76MP0006035_abnormal_mitochondrial_morpho1.13401070
77MP0002163_abnormal_gland_morphology1.13338071
78MP0003300_gastrointestinal_ulcer1.09896368
79MP0009278_abnormal_bone_marrow1.09541104
80MP0009703_decreased_birth_body1.09230547
81MP0009672_abnormal_birth_weight1.08630711
82MP0000733_abnormal_muscle_development1.08537604
83MP0005623_abnormal_meninges_morphology1.06449147
84MP0008770_decreased_survivor_rate1.06338461
85MP0005310_abnormal_salivary_gland1.06046192
86MP0003183_abnormal_peptide_metabolism1.04637023
87MP0000689_abnormal_spleen_morphology1.00913977
88MP0001293_anophthalmia0.99155578
89MP0003567_abnormal_fetal_cardiomyocyte0.98846903
90MP0002092_abnormal_eye_morphology0.98639819
91MP0004381_abnormal_hair_follicle0.96770209
92MP0001915_intracranial_hemorrhage0.94380708
93MP0000003_abnormal_adipose_tissue0.93713464
94MP0003786_premature_aging0.93354900
95MP0004264_abnormal_extraembryonic_tissu0.91687747
96MP0002111_abnormal_tail_morphology0.91564765
97MP0003718_maternal_effect0.91157733
98MP0009333_abnormal_splenocyte_physiolog0.89836513
99MP0003221_abnormal_cardiomyocyte_apopto0.89821165
100MP0002925_abnormal_cardiovascular_devel0.88104078
101MP0000537_abnormal_urethra_morphology0.87582853
102MP0000015_abnormal_ear_pigmentation0.86830956
103MP0002429_abnormal_blood_cell0.84571870
104MP0005501_abnormal_skin_physiology0.84482111
105MP0002697_abnormal_eye_size0.83389537
106MP0002006_tumorigenesis0.82183429
107MP0006292_abnormal_olfactory_placode0.77692886
108MP0000049_abnormal_middle_ear0.77545582
109MP0005621_abnormal_cell_physiology0.76696641
110MP0001849_ear_inflammation0.75784181
111MP0000613_abnormal_salivary_gland0.74884397
112MP0005384_cellular_phenotype0.74055834
113MP0003115_abnormal_respiratory_system0.74006505
114MP0000266_abnormal_heart_morphology0.73364775
115MP0010155_abnormal_intestine_physiology0.73163877
116MP0000685_abnormal_immune_system0.72331508
117MP0003935_abnormal_craniofacial_develop0.71606144
118MP0001286_abnormal_eye_development0.71569691
119MP0002160_abnormal_reproductive_system0.70294588
120MP0001845_abnormal_inflammatory_respons0.69772631
121MP0004233_abnormal_muscle_weight0.69645910
122MP0009931_abnormal_skin_appearance0.68978517
123MP0003303_peritoneal_inflammation0.68590093
124MP0002083_premature_death0.68473265
125MP0000432_abnormal_head_morphology0.67003571
126MP0003861_abnormal_nervous_system0.66509246
127MP0008789_abnormal_olfactory_epithelium0.64470384
128MP0005025_abnormal_response_to0.64172779
129MP0001784_abnormal_fluid_regulation0.63762548
130MP0002928_abnormal_bile_duct0.62951582
131MP0003119_abnormal_digestive_system0.62808463
132MP0002210_abnormal_sex_determination0.60961412
133MP0002932_abnormal_joint_morphology0.60798985
134MP0002249_abnormal_larynx_morphology0.59982281
135MP0002877_abnormal_melanocyte_morpholog0.59096929
136MP0005075_abnormal_melanosome_morpholog0.58674486
137MP0001191_abnormal_skin_condition0.57115455
138MP0000428_abnormal_craniofacial_morphol0.56929746
139MP0004947_skin_inflammation0.56600407
140MP0001929_abnormal_gametogenesis0.56590264
141MP0003566_abnormal_cell_adhesion0.55836769
142MP0000383_abnormal_hair_follicle0.55729243
143MP0000716_abnormal_immune_system0.55270018
144MP0002095_abnormal_skin_pigmentation0.55004856
145MP0001145_abnormal_male_reproductive0.54969686
146MP0003315_abnormal_perineum_morphology0.53915573
147MP0003448_altered_tumor_morphology0.52119966
148MP0000477_abnormal_intestine_morphology0.50700129
149MP0005647_abnormal_sex_gland0.50235553
150MP0001764_abnormal_homeostasis0.49706254
151MP0000653_abnormal_sex_gland0.49096803

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)9.46694825
2Abnormality of the heme biosynthetic pathway (HP:0010472)6.77114785
3Hypochromic microcytic anemia (HP:0004840)6.72128865
4IgM deficiency (HP:0002850)6.01916684
5IgA deficiency (HP:0002720)5.77317859
6Acanthocytosis (HP:0001927)5.60305004
7Colitis (HP:0002583)5.34330489
8Agammaglobulinemia (HP:0004432)5.04513031
9Reticulocytosis (HP:0001923)4.73071750
10Gastrointestinal stroma tumor (HP:0100723)4.67452031
11Cholelithiasis (HP:0001081)4.00869434
12Recurrent sinusitis (HP:0011108)3.93900163
13Abnormality of reticulocytes (HP:0004312)3.93373988
14Cellulitis (HP:0100658)3.92301669
15Dry hair (HP:0011359)3.90792963
16Panhypogammaglobulinemia (HP:0003139)3.87219403
17Insomnia (HP:0100785)3.63682363
18Recurrent bronchitis (HP:0002837)3.60805495
19Diaphragmatic weakness (HP:0009113)3.54743823
20Abnormality of the fingertips (HP:0001211)3.53496827
21Abnormal gallbladder morphology (HP:0012437)3.47832201
22Microvesicular hepatic steatosis (HP:0001414)3.41427918
23Hypochromic anemia (HP:0001931)3.37319324
24B lymphocytopenia (HP:0010976)3.36302148
25Short 4th metacarpal (HP:0010044)3.34869644
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.34869644
27Chromsome breakage (HP:0040012)3.34252415
28Inflammation of the large intestine (HP:0002037)3.17256451
29Chromosomal breakage induced by crosslinking agents (HP:0003221)3.13365837
30Volvulus (HP:0002580)3.09285724
31Impulsivity (HP:0100710)3.07433848
32Abnormality of chromosome stability (HP:0003220)3.07393594
33Abnormality of B cell number (HP:0010975)3.05300650
34Viral hepatitis (HP:0006562)2.98717908
35Meningitis (HP:0001287)2.98500081
36Abnormality of T cell physiology (HP:0011840)2.95779738
37Gastrointestinal inflammation (HP:0004386)2.95258660
38Lymphopenia (HP:0001888)2.94735591
393-Methylglutaconic aciduria (HP:0003535)2.90505784
40Recurrent viral infections (HP:0004429)2.90501280
41Osteomalacia (HP:0002749)2.86232355
42Abnormality of cells of the lymphoid lineage (HP:0012140)2.85943443
43Birth length less than 3rd percentile (HP:0003561)2.81574514
44Thyroiditis (HP:0100646)2.80482234
45Erythema (HP:0010783)2.73121513
46High pitched voice (HP:0001620)2.72950807
47Paralysis (HP:0003470)2.68120123
48Increased nuchal translucency (HP:0010880)2.57337243
49Cutaneous photosensitivity (HP:0000992)2.55196722
50Prominent nose (HP:0000448)2.55174677
51Long eyelashes (HP:0000527)2.54179571
52Reticulocytopenia (HP:0001896)2.51689077
53Aplasia/Hypoplasia of the sacrum (HP:0008517)2.51084030
54Hyperbilirubinemia (HP:0002904)2.49609567
55Abnormality of the gallbladder (HP:0005264)2.48586575
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.47810268
57Spastic diplegia (HP:0001264)2.47304862
58Lymphoma (HP:0002665)2.46757902
59Hepatitis (HP:0012115)2.45086988
60Recurrent lower respiratory tract infections (HP:0002783)2.44299923
61Meckel diverticulum (HP:0002245)2.43074762
62Microcytic anemia (HP:0001935)2.43054745
63Duodenal stenosis (HP:0100867)2.41683300
64Small intestinal stenosis (HP:0012848)2.41683300
65Cafe-au-lait spot (HP:0000957)2.40166806
66Lipid accumulation in hepatocytes (HP:0006561)2.38783912
67Medulloblastoma (HP:0002885)2.34777796
68Emphysema (HP:0002097)2.34661356
69Recurrent pneumonia (HP:0006532)2.32784362
70Increased intramyocellular lipid droplets (HP:0012240)2.32646329
71IgG deficiency (HP:0004315)2.32412511
72Basal cell carcinoma (HP:0002671)2.30678257
73Clubbing of toes (HP:0100760)2.30620271
74Ridged nail (HP:0001807)2.30251483
75Abnormality of the ileum (HP:0001549)2.29347515
76Ependymoma (HP:0002888)2.27537077
77Ectopic kidney (HP:0000086)2.27249371
78Aplasia/Hypoplasia of the uvula (HP:0010293)2.25892414
79Increased muscle lipid content (HP:0009058)2.24472633
80Mediastinal lymphadenopathy (HP:0100721)2.23625645
81Patellar aplasia (HP:0006443)2.21702530
82Large eyes (HP:0001090)2.21076740
83Abnormality of the 4th metacarpal (HP:0010012)2.20751341
84Broad distal phalanx of finger (HP:0009836)2.19051648
85Abnormality of the labia minora (HP:0012880)2.18717186
86Leukopenia (HP:0001882)2.18310038
87Onycholysis (HP:0001806)2.17929010
8811 pairs of ribs (HP:0000878)2.16249120
89Heterotopia (HP:0002282)2.15229410
90Selective tooth agenesis (HP:0001592)2.14598162
91Abnormality of chromosome segregation (HP:0002916)2.14472455
92Osteomyelitis (HP:0002754)2.11419036
93Abnormal number of incisors (HP:0011064)2.10963801
94Chronic diarrhea (HP:0002028)2.10874445
95Abnormality of cells of the erythroid lineage (HP:0012130)2.08844855
96Renal duplication (HP:0000075)2.07650818
97Truncal obesity (HP:0001956)2.06192946
98Abnormality of the duodenum (HP:0002246)2.06174920
99Microtia (HP:0008551)2.06064083
100Proximal placement of thumb (HP:0009623)2.05116358
101Aplasia/Hypoplasia of the patella (HP:0006498)2.04768882
102Abnormality of the prostate (HP:0008775)2.03969112
103Sandal gap (HP:0001852)2.01794497
104Colon cancer (HP:0003003)2.00680648
105Deviation of the thumb (HP:0009603)2.00583777
106Abnormality of small intestinal villus morphology (HP:0011472)1.99148724
107Villous atrophy (HP:0011473)1.99148724
108Abnormality of the preputium (HP:0100587)1.98923505
109Prostate neoplasm (HP:0100787)1.98135805
110Cortical dysplasia (HP:0002539)1.96555363
111Acute lymphatic leukemia (HP:0006721)1.96462796
112Rib fusion (HP:0000902)1.96442026
113Abnormal number of erythroid precursors (HP:0012131)1.95372979
114Short middle phalanx of the 5th finger (HP:0004220)1.94375242
115Increased hepatocellular lipid droplets (HP:0006565)1.93894037
116Increased serum lactate (HP:0002151)1.92427911
117Abnormality of the astrocytes (HP:0100707)1.90693554
118Astrocytoma (HP:0009592)1.90693554
119Atresia of the external auditory canal (HP:0000413)1.89568592
120Petechiae (HP:0000967)1.88629283
121Bronchitis (HP:0012387)1.87320774
122Recurrent fungal infections (HP:0002841)1.85243845
123Macrocytic anemia (HP:0001972)1.84899658
124Orthostatic hypotension (HP:0001278)1.84493636
125Sparse scalp hair (HP:0002209)1.84214591
126Abnormality of T cells (HP:0002843)1.84125451
127Aplasia/Hypoplasia of the sternum (HP:0006714)1.84080616
128Deep palmar crease (HP:0006191)1.83543051
129Skin rash (HP:0000988)1.82246006
130Urticaria (HP:0001025)1.82233861
131Broad thumb (HP:0011304)1.81622535
132Combined immunodeficiency (HP:0005387)1.80793957
133Neutropenia (HP:0001875)1.80549594
134Autoimmune hemolytic anemia (HP:0001890)1.80303017
135Myelodysplasia (HP:0002863)1.79270576
136Obsessive-compulsive behavior (HP:0000722)1.78883847
137Dyschromatopsia (HP:0007641)1.78646356
138Rhabdomyosarcoma (HP:0002859)1.76690375
139Squamous cell carcinoma (HP:0002860)1.75772885
140Trigonocephaly (HP:0000243)1.75585359
141Abnormality of the carotid arteries (HP:0005344)1.74880186
142Sloping forehead (HP:0000340)1.74844596
143Gastrointestinal carcinoma (HP:0002672)1.74549847
144Malignant gastrointestinal tract tumors (HP:0006749)1.74549847
145Cerebral edema (HP:0002181)1.73307559
146Deep philtrum (HP:0002002)1.73194585
147Abnormal mitochondria in muscle tissue (HP:0008316)1.72883396
148Macroorchidism (HP:0000053)1.72158924
149Severe combined immunodeficiency (HP:0004430)1.70960102
150Glioma (HP:0009733)1.70799342
151Anal stenosis (HP:0002025)1.70445995
152Abnormality of abdominal situs (HP:0011620)1.70422304
153Abdominal situs inversus (HP:0003363)1.70422304
154Chronic mucocutaneous candidiasis (HP:0002728)1.70354224
155Recurrent cutaneous fungal infections (HP:0011370)1.70354224
156Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69534106
157Vasculitis (HP:0002633)1.69457969
158Recurrent bacterial skin infections (HP:0005406)1.69419000
159Recurrent otitis media (HP:0000403)1.68764079
160Verrucae (HP:0200043)1.67941939
161Papilloma (HP:0012740)1.67941939
162Abnormal lung lobation (HP:0002101)1.67401511
163Abnormal gallbladder physiology (HP:0012438)1.67288979
164Cholecystitis (HP:0001082)1.67288979
165Increased CSF lactate (HP:0002490)1.66847077
166Aplasia/Hypoplasia of the earlobes (HP:0009906)1.66562554
167Neoplasm of the oral cavity (HP:0100649)1.64000946
168Broad palm (HP:0001169)1.63796359
169Nephroblastoma (Wilms tumor) (HP:0002667)1.62043982
170Short 5th finger (HP:0009237)1.59740739
171Skin tags (HP:0010609)1.59595195
172Cutis marmorata (HP:0000965)1.59274970
173Ulnar bowing (HP:0003031)1.57246402
174Hyponatremia (HP:0002902)1.55599980
175Biliary tract neoplasm (HP:0100574)1.55167579
176Agnosia (HP:0010524)1.54480282
177Cutaneous melanoma (HP:0012056)1.53907211

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK18.88022326
2ZAK5.85648491
3STK44.04377083
4CDK123.99053398
5CDC73.57769228
6VRK13.42130500
7RPS6KA53.01197844
8MAP3K102.23710525
9NEK22.21861432
10EIF2AK12.05779873
11CDK91.99061362
12SMG11.85295605
13AURKB1.81231238
14MAP3K81.79905335
15BRD41.75982476
16PIM11.75190519
17BCKDK1.73617789
18EEF2K1.63915239
19CDK81.55052800
20CHEK21.49536799
21WEE11.40379580
22SCYL21.39360273
23DYRK31.38140637
24CAMK1D1.35609894
25TTK1.26249679
26BUB11.23204444
27GRK61.16251121
28CDK41.11718648
29STK101.10417134
30SRPK11.06579806
31PLK11.05481995
32ATR1.02982239
33CDK61.02612487
34TAF11.01787219
35RPS6KB20.95267046
36AURKA0.95069680
37BMPR1B0.93900945
38NEK10.89737429
39PKN10.87956422
40CHEK10.85585925
41PRKAA10.85159402
42MELK0.80141658
43STK30.78511214
44BTK0.77330557
45BLK0.76448983
46BRSK10.76190246
47ATM0.75466825
48IRAK40.74943797
49TRIB30.74649094
50MAPKAPK50.74134214
51CDK70.73777594
52DYRK1B0.71584278
53PKN20.70794702
54CDK20.68324169
55CAMK1G0.66720259
56ACVR1B0.65698330
57DAPK30.65626014
58PLK30.62621345
59NME20.62590980
60AKT20.57246119
61CDK10.57233827
62BRAF0.55227434
63KDR0.53538786
64MAP2K70.53376306
65BRSK20.53132859
66VRK20.49225500
67MTOR0.47827255
68ERBB20.47152758
69CSNK1G30.46525421
70PBK0.45539078
71TRPM70.44987192
72TTN0.44722258
73MAP2K30.44036890
74PASK0.42725025
75MAP3K40.41814272
76LYN0.40337583
77PIK3CG0.39126191
78CSNK1D0.38815596
79SGK10.38465923
80CSNK1A1L0.38351414
81PLK40.37760143
82CSNK1G10.36119970
83PIM20.36063205
84ICK0.33732851
85RPS6KA40.33288343
86MAPK140.33004001
87LATS10.32990203
88FLT30.31936113
89STK160.31815786
90EIF2AK20.31660607
91LRRK20.31024672
92MAPK110.30227253
93AKT10.27868286
94JAK20.27068550
95PRKDC0.26514585
96EPHA20.25390238
97CCNB10.25317067
98CLK10.25182135
99BMX0.25138479
100MAP4K10.24990467
101MAPKAPK30.23844744
102MAP4K20.23803357
103PAK10.23715119
104RAF10.22309713
105SGK30.21908533
106PRKCQ0.21466044
107RPS6KA30.21436172
108PRKCI0.21293025
109ARAF0.20951084
110MAP2K40.19789080
111IRAK30.19479264
112CHUK0.18836375
113CAMK40.18636247
114IKBKB0.18498910
115EIF2AK30.16715537
116ROCK10.16360011
117GSK3B0.16317492
118PRKCD0.15950598
119MAPK10.15809250
120RPS6KL10.15404569
121RPS6KC10.15404569
122CDK190.14962630
123TGFBR10.14718390
124TEC0.13447985
125KIT0.13335146
126PRPF4B0.13120721
127CSNK1G20.12808280
128RPS6KA10.12228566
129NEK90.12118514
130PRKCB0.11528382
131KSR10.11311627
132CSNK2A20.10757308
133MKNK10.10669463
134SYK0.10540208
135MKNK20.10054039
136ILK0.09693904
137IRAK20.09599323
138TBK10.08992142
139MAPK80.08688212
140EPHA30.08635654
141RPS6KA60.08421668
142HCK0.08341396
143MARK30.07210750
144CAMKK20.05395592
145DAPK10.04716968

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.40086059
2Viral carcinogenesis_Homo sapiens_hsa052033.38562271
3DNA replication_Homo sapiens_hsa030302.88736470
4Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.54256562
5Cell cycle_Homo sapiens_hsa041102.36918258
6Mismatch repair_Homo sapiens_hsa034302.26178449
7* Systemic lupus erythematosus_Homo sapiens_hsa0532211.2681898
8Transcriptional misregulation in cancer_Homo sapiens_hsa052021.84442078
9Asthma_Homo sapiens_hsa053101.67903604
10Fanconi anemia pathway_Homo sapiens_hsa034601.65260118
11Base excision repair_Homo sapiens_hsa034101.55561213
12Homologous recombination_Homo sapiens_hsa034401.53263967
13Nucleotide excision repair_Homo sapiens_hsa034201.48070158
14One carbon pool by folate_Homo sapiens_hsa006701.41202698
15Allograft rejection_Homo sapiens_hsa053301.40181413
16Non-homologous end-joining_Homo sapiens_hsa034501.39976965
17Autoimmune thyroid disease_Homo sapiens_hsa053201.32838773
18RNA transport_Homo sapiens_hsa030131.29889925
19Spliceosome_Homo sapiens_hsa030401.27031966
20Graft-versus-host disease_Homo sapiens_hsa053321.16757070
21p53 signaling pathway_Homo sapiens_hsa041151.14841348
22mRNA surveillance pathway_Homo sapiens_hsa030151.02477374
23MicroRNAs in cancer_Homo sapiens_hsa052060.99627904
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97976189
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95464396
26Type I diabetes mellitus_Homo sapiens_hsa049400.95306411
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92189984
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91690867
29Ribosome_Homo sapiens_hsa030100.91494730
30Chronic myeloid leukemia_Homo sapiens_hsa052200.84712771
31Small cell lung cancer_Homo sapiens_hsa052220.82711611
32Oocyte meiosis_Homo sapiens_hsa041140.80256881
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79011657
34Non-small cell lung cancer_Homo sapiens_hsa052230.78874975
35Herpes simplex infection_Homo sapiens_hsa051680.73759510
36Lysine degradation_Homo sapiens_hsa003100.73317351
37HTLV-I infection_Homo sapiens_hsa051660.71750043
38Bladder cancer_Homo sapiens_hsa052190.70770847
39Malaria_Homo sapiens_hsa051440.69683107
40Hematopoietic cell lineage_Homo sapiens_hsa046400.67491921
41Pyrimidine metabolism_Homo sapiens_hsa002400.64849260
42Dorso-ventral axis formation_Homo sapiens_hsa043200.58328952
43RNA degradation_Homo sapiens_hsa030180.56117947
44Pancreatic cancer_Homo sapiens_hsa052120.55915160
45Biosynthesis of amino acids_Homo sapiens_hsa012300.53274222
46Apoptosis_Homo sapiens_hsa042100.52507569
47Prostate cancer_Homo sapiens_hsa052150.52005992
48Hepatitis B_Homo sapiens_hsa051610.51936741
49Epstein-Barr virus infection_Homo sapiens_hsa051690.49654554
50Basal cell carcinoma_Homo sapiens_hsa052170.46919968
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45865475
52TGF-beta signaling pathway_Homo sapiens_hsa043500.45737201
53Notch signaling pathway_Homo sapiens_hsa043300.45530089
54Antigen processing and presentation_Homo sapiens_hsa046120.44607749
55Glioma_Homo sapiens_hsa052140.44238870
56Selenocompound metabolism_Homo sapiens_hsa004500.43588811
57Colorectal cancer_Homo sapiens_hsa052100.42594367
58FoxO signaling pathway_Homo sapiens_hsa040680.42044192
59mTOR signaling pathway_Homo sapiens_hsa041500.41922675
60Proteasome_Homo sapiens_hsa030500.37822399
61Measles_Homo sapiens_hsa051620.34538872
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34088584
63Thyroid cancer_Homo sapiens_hsa052160.33188851
64Adherens junction_Homo sapiens_hsa045200.32961805
65Hippo signaling pathway_Homo sapiens_hsa043900.32591227
66Endometrial cancer_Homo sapiens_hsa052130.31606210
67RNA polymerase_Homo sapiens_hsa030200.31599841
68Proteoglycans in cancer_Homo sapiens_hsa052050.31372041
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30701894
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.29933634
71N-Glycan biosynthesis_Homo sapiens_hsa005100.29551312
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29242093
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28553292
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28489476
75Fructose and mannose metabolism_Homo sapiens_hsa000510.27018427
76Carbon metabolism_Homo sapiens_hsa012000.26354227
77AMPK signaling pathway_Homo sapiens_hsa041520.26312023
78Sulfur relay system_Homo sapiens_hsa041220.26310625
79Basal transcription factors_Homo sapiens_hsa030220.25983905
80Pathways in cancer_Homo sapiens_hsa052000.25973889
81Staphylococcus aureus infection_Homo sapiens_hsa051500.25541227
82B cell receptor signaling pathway_Homo sapiens_hsa046620.25494854
83Melanoma_Homo sapiens_hsa052180.25474741
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24455372
85Galactose metabolism_Homo sapiens_hsa000520.23614819
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.23412094
87ABC transporters_Homo sapiens_hsa020100.23143495
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22714627
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22706483
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22649777
91Influenza A_Homo sapiens_hsa051640.21661496
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21407199
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21230102
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.19879998
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19765556
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.19687523
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.19371478
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19329856
99Vitamin B6 metabolism_Homo sapiens_hsa007500.18189629
100Renin-angiotensin system_Homo sapiens_hsa046140.16715038
101Huntingtons disease_Homo sapiens_hsa050160.16693059
102Purine metabolism_Homo sapiens_hsa002300.14578999
103Hedgehog signaling pathway_Homo sapiens_hsa043400.14509836
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.14334360
105Platelet activation_Homo sapiens_hsa046110.14279604
106Wnt signaling pathway_Homo sapiens_hsa043100.13920775
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13540518
108Acute myeloid leukemia_Homo sapiens_hsa052210.12567805
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.12265106
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12033210
111Primary immunodeficiency_Homo sapiens_hsa053400.11519561
112HIF-1 signaling pathway_Homo sapiens_hsa040660.11259623
113Tuberculosis_Homo sapiens_hsa051520.10972983
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.10965317
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.10746829
116Parkinsons disease_Homo sapiens_hsa050120.10640211
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.09790711
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.09729779
119Viral myocarditis_Homo sapiens_hsa054160.08218779
120Leishmaniasis_Homo sapiens_hsa051400.08169869
121Tight junction_Homo sapiens_hsa045300.07744850
122Oxidative phosphorylation_Homo sapiens_hsa001900.07402817
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.07394061
124Inositol phosphate metabolism_Homo sapiens_hsa005620.07156587
125Focal adhesion_Homo sapiens_hsa045100.07094629
126Toxoplasmosis_Homo sapiens_hsa051450.06953364
127Pentose phosphate pathway_Homo sapiens_hsa000300.06565566
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.05816192
129Phenylalanine metabolism_Homo sapiens_hsa003600.05422197
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.05395413
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.05357647
132Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.04379322
133Rheumatoid arthritis_Homo sapiens_hsa053230.03954180
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.03533422
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.02880011

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