HIST1H2AM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1innate immune response in mucosa (GO:0002227)8.97930603
2DNA replication-dependent nucleosome assembly (GO:0006335)8.77736760
3DNA replication-dependent nucleosome organization (GO:0034723)8.77736760
4nucleosome assembly (GO:0006334)7.61679552
5mucosal immune response (GO:0002385)7.39476947
6antibacterial humoral response (GO:0019731)7.24607238
7regulation of histone H3-K9 methylation (GO:0051570)6.74855098
8chromatin assembly (GO:0031497)6.74462974
9organ or tissue specific immune response (GO:0002251)6.65969642
10protein-DNA complex assembly (GO:0065004)6.60046722
11nuclear pore complex assembly (GO:0051292)6.59016807
12antimicrobial humoral response (GO:0019730)6.57150892
13nucleosome organization (GO:0034728)6.40626029
14nuclear pore organization (GO:0006999)5.83984586
15protein-DNA complex subunit organization (GO:0071824)5.71375104
16chromatin assembly or disassembly (GO:0006333)5.53087436
17DNA unwinding involved in DNA replication (GO:0006268)5.50688899
18DNA strand elongation involved in DNA replication (GO:0006271)5.36350775
19mitotic chromosome condensation (GO:0007076)5.26480263
20DNA strand elongation (GO:0022616)5.22636789
21pore complex assembly (GO:0046931)5.05093557
22telomere maintenance via semi-conservative replication (GO:0032201)4.99341572
23CENP-A containing nucleosome assembly (GO:0034080)4.87496354
24chromatin remodeling at centromere (GO:0031055)4.79190178
25protein localization to chromosome, centromeric region (GO:0071459)4.76741645
26DNA replication initiation (GO:0006270)4.60554785
27mitotic sister chromatid segregation (GO:0000070)4.51740648
28telomere maintenance via recombination (GO:0000722)4.46630031
29sister chromatid segregation (GO:0000819)4.40131017
30mitotic recombination (GO:0006312)4.35124191
31negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.17565020
32V(D)J recombination (GO:0033151)3.98878901
33regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.94036288
34regulation of sister chromatid cohesion (GO:0007063)3.88871962
35kinetochore organization (GO:0051383)3.87895586
36meiotic chromosome segregation (GO:0045132)3.86715289
37protein localization to kinetochore (GO:0034501)3.80666876
38DNA duplex unwinding (GO:0032508)3.76778716
39nucleotide-excision repair, DNA gap filling (GO:0006297)3.73286679
40double-strand break repair via nonhomologous end joining (GO:0006303)3.72110947
41non-recombinational repair (GO:0000726)3.72110947
42DNA geometric change (GO:0032392)3.65987431
43DNA replication-independent nucleosome organization (GO:0034724)3.64080716
44DNA replication-independent nucleosome assembly (GO:0006336)3.64080716
45regulation of megakaryocyte differentiation (GO:0045652)3.63811778
46mitotic sister chromatid cohesion (GO:0007064)3.62677030
47telomere maintenance via telomere lengthening (GO:0010833)3.62413149
48histone exchange (GO:0043486)3.61914587
49DNA ligation (GO:0006266)3.61509378
50DNA synthesis involved in DNA repair (GO:0000731)3.60089170
51viral mRNA export from host cell nucleus (GO:0046784)3.58598408
52telomere organization (GO:0032200)3.56171315
53telomere maintenance (GO:0000723)3.55505453
54regulation of centrosome cycle (GO:0046605)3.54869552
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.54818467
56mitotic nuclear envelope disassembly (GO:0007077)3.51842821
57DNA replication checkpoint (GO:0000076)3.48318198
58regulation of chromosome segregation (GO:0051983)3.48015019
59DNA topological change (GO:0006265)3.40210122
60negative regulation of chromosome segregation (GO:0051985)3.40086608
61translesion synthesis (GO:0019985)3.36887019
62regulation of centriole replication (GO:0046599)3.33983569
63mitotic metaphase plate congression (GO:0007080)3.33077215
64DNA conformation change (GO:0071103)3.29362003
65regulation of sister chromatid segregation (GO:0033045)3.27100292
66regulation of mitotic sister chromatid separation (GO:0010965)3.27100292
67regulation of mitotic sister chromatid segregation (GO:0033047)3.27100292
68regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.25807189
69regulation of mitotic metaphase/anaphase transition (GO:0030071)3.25807189
70negative regulation of mitotic sister chromatid separation (GO:2000816)3.24234731
71negative regulation of sister chromatid segregation (GO:0033046)3.24234731
72negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.24234731
73negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.24234731
74negative regulation of mitotic sister chromatid segregation (GO:0033048)3.24234731
75chromosome condensation (GO:0030261)3.22889757
76membrane disassembly (GO:0030397)3.21491709
77nuclear envelope disassembly (GO:0051081)3.21491709
78regulation of translational fidelity (GO:0006450)3.21162503
79positive regulation of histone methylation (GO:0031062)3.19291314
80maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.17128733
81mitotic spindle assembly checkpoint (GO:0007094)3.17085610
82spindle checkpoint (GO:0031577)3.16327196
83positive regulation of chromosome segregation (GO:0051984)3.15530335
84somatic hypermutation of immunoglobulin genes (GO:0016446)3.14133014
85somatic diversification of immune receptors via somatic mutation (GO:0002566)3.14133014
86spindle assembly checkpoint (GO:0071173)3.13964910
87somatic cell DNA recombination (GO:0016444)3.13267039
88somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.13267039
89regulation of centrosome duplication (GO:0010824)3.11816474
90kinetochore assembly (GO:0051382)3.10115923
91metaphase plate congression (GO:0051310)3.10038880
92ATP-dependent chromatin remodeling (GO:0043044)3.08122937
93replicative senescence (GO:0090399)3.05457582
94chromosome segregation (GO:0007059)3.05438926
95ribosomal small subunit biogenesis (GO:0042274)3.05059624
96mitotic spindle checkpoint (GO:0071174)3.05056943
97positive regulation of mitotic sister chromatid separation (GO:1901970)3.03838277
98positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.03838277
99positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.03838277
100replication fork processing (GO:0031297)2.98742720

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.60140556
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.10371655
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.74036209
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.88095716
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.53471840
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92303442
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.58663451
8* E2F1_21310950_ChIP-Seq_MCF-7_Human2.34550413
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.25761649
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20659839
11MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.16549866
12* SOX2_16153702_ChIP-ChIP_HESCs_Human2.10361059
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.07279502
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse15.3212807
15* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.85201702
16NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78963681
17CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.78196832
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78190440
19MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76176655
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74332889
21GATA1_22025678_ChIP-Seq_K562_Human1.71613032
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70584042
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68768780
24HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.60904766
25AR_21909140_ChIP-Seq_LNCAP_Human1.58622484
26HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57611921
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56429460
28ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53348518
29IRF1_19129219_ChIP-ChIP_H3396_Human1.49850938
30ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48911785
31VDR_23849224_ChIP-Seq_CD4+_Human1.46820013
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38360264
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38254321
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38023259
35SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.35707023
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27356203
37POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23403339
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23311835
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22239303
40MYC_22102868_ChIP-Seq_BL_Human1.21755163
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20092033
42* ELK1_19687146_ChIP-ChIP_HELA_Human1.19411295
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.19273796
44FOXP3_21729870_ChIP-Seq_TREG_Human1.18060323
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16899817
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16195245
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16025930
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13211109
49* NANOG_16153702_ChIP-ChIP_HESCs_Human1.12147691
50SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10115200
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08943572
52* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07736537
53ETS1_20019798_ChIP-Seq_JURKAT_Human1.06177804
54XRN2_22483619_ChIP-Seq_HELA_Human1.05356546
55EST1_17652178_ChIP-ChIP_JURKAT_Human1.03501688
56DCP1A_22483619_ChIP-Seq_HELA_Human1.03122569
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03040544
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01248450
59MYC_18940864_ChIP-ChIP_HL60_Human1.01210649
60KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00853923
61VDR_21846776_ChIP-Seq_THP-1_Human0.97296999
62ETS1_22383799_ChIP-Seq_G1ME_Mouse0.95875331
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94276818
64ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93378874
65ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92310680
66CIITA_25753668_ChIP-Seq_RAJI_Human0.92225965
67DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89550974
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88793375
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.88616018
70GABP_17652178_ChIP-ChIP_JURKAT_Human0.87700306
71MYCN_18555785_ChIP-Seq_MESCs_Mouse0.87603478
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87283636
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87182403
74SOX2_18692474_ChIP-Seq_MESCs_Mouse0.86386122
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.84997539
76ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84874051
77NANOG_18555785_ChIP-Seq_MESCs_Mouse0.84732175
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.82472782
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82411920
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.79631512
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79325131
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78195958
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.77531676
84TTF2_22483619_ChIP-Seq_HELA_Human0.77090207
85KDM5A_27292631_Chip-Seq_BREAST_Human0.75793424
86BRD4_27068464_Chip-Seq_AML-cells_Mouse0.75498924
87GABP_19822575_ChIP-Seq_HepG2_Human0.72581496
88NOTCH1_21737748_ChIP-Seq_TLL_Human0.72439765
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.70383696
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.69926897
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.69039589
92NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.68630861
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.68068562
94ZNF263_19887448_ChIP-Seq_K562_Human0.67372233
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.65706587
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.65591105
97STAT3_1855785_ChIP-Seq_MESCs_Mouse0.65295798
98SRF_21415370_ChIP-Seq_HL-1_Mouse0.64754764
99PKCTHETA_26484144_Chip-Seq_BREAST_Human0.63885192
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.61436985

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.84509180
2MP0010094_abnormal_chromosome_stability5.72179124
3MP0003111_abnormal_nucleus_morphology4.73574294
4MP0003693_abnormal_embryo_hatching4.41139802
5MP0003077_abnormal_cell_cycle4.25340668
6MP0004957_abnormal_blastocyst_morpholog3.63590767
7MP0008058_abnormal_DNA_repair3.03253671
8MP0002396_abnormal_hematopoietic_system2.83892265
9MP0009697_abnormal_copulation2.78980474
10MP0010352_gastrointestinal_tract_polyps2.78463366
11MP0004147_increased_porphyrin_level2.55000885
12MP0002009_preneoplasia2.51764186
13MP0008932_abnormal_embryonic_tissue2.43447086
14MP0010307_abnormal_tumor_latency2.36028114
15MP0008007_abnormal_cellular_replicative2.29602657
16MP0003786_premature_aging2.17243489
17MP0003763_abnormal_thymus_physiology2.15678975
18MP0000350_abnormal_cell_proliferation2.02768316
19MP0004808_abnormal_hematopoietic_stem1.96947566
20MP0005083_abnormal_biliary_tract1.78722099
21MP0001661_extended_life_span1.69337147
22MP0003656_abnormal_erythrocyte_physiolo1.68807777
23MP0003718_maternal_effect1.66747905
24MP0002019_abnormal_tumor_incidence1.59097214
25MP0002166_altered_tumor_susceptibility1.58951261
26MP0000313_abnormal_cell_death1.57800528
27MP0000490_abnormal_crypts_of1.46435409
28MP0001730_embryonic_growth_arrest1.45514510
29MP0004185_abnormal_adipocyte_glucose1.44530806
30MP0009278_abnormal_bone_marrow1.40563941
31MP0002398_abnormal_bone_marrow1.37215572
32MP0002006_tumorigenesis1.35543958
33MP0005380_embryogenesis_phenotype1.35475265
34MP0001672_abnormal_embryogenesis/_devel1.35475265
35MP0005076_abnormal_cell_differentiation1.30124464
36MP0001697_abnormal_embryo_size1.26191637
37MP0001545_abnormal_hematopoietic_system1.25856700
38MP0005397_hematopoietic_system_phenotyp1.25856700
39MP0000703_abnormal_thymus_morphology1.25727968
40MP0003984_embryonic_growth_retardation1.25373625
41MP0002722_abnormal_immune_system1.24714883
42MP0002080_prenatal_lethality1.23817080
43MP0002086_abnormal_extraembryonic_tissu1.21557155
44MP0010234_abnormal_vibrissa_follicle1.20817991
45MP0002088_abnormal_embryonic_growth/wei1.19154733
46MP0000537_abnormal_urethra_morphology1.15895362
47MP0000685_abnormal_immune_system1.13885066
48MP0005220_abnormal_exocrine_pancreas1.13274705
49MP0000689_abnormal_spleen_morphology1.10898498
50MP0005645_abnormal_hypothalamus_physiol1.10595893
51MP0006035_abnormal_mitochondrial_morpho1.09818027
52MP0000358_abnormal_cell_content/1.09056988
53MP0008995_early_reproductive_senescence1.06734948
54MP0002084_abnormal_developmental_patter0.99271362
55MP0001835_abnormal_antigen_presentation0.98047247
56MP0002085_abnormal_embryonic_tissue0.94103660
57MP0001929_abnormal_gametogenesis0.92424164
58MP0002429_abnormal_blood_cell0.91162759
59MP0002877_abnormal_melanocyte_morpholog0.88319680
60MP0002160_abnormal_reproductive_system0.87629185
61MP0002210_abnormal_sex_determination0.85438062
62MP0004233_abnormal_muscle_weight0.83358423
63MP0005384_cellular_phenotype0.82803890
64MP0005621_abnormal_cell_physiology0.80759828
65MP0002163_abnormal_gland_morphology0.79342935
66MP0005501_abnormal_skin_physiology0.79132513
67MP0000015_abnormal_ear_pigmentation0.78361397
68MP0001800_abnormal_humoral_immune0.77208348
69MP0002697_abnormal_eye_size0.75745009
70MP0000465_gastrointestinal_hemorrhage0.74788809
71MP0001145_abnormal_male_reproductive0.74649460
72MP0003699_abnormal_female_reproductive0.74632079
73MP0002111_abnormal_tail_morphology0.73834415
74MP0000013_abnormal_adipose_tissue0.73189275
75MP0003941_abnormal_skin_development0.72961614
76MP0001119_abnormal_female_reproductive0.72283798
77MP0000716_abnormal_immune_system0.71773776
78MP0001293_anophthalmia0.70653575
79MP0004197_abnormal_fetal_growth/weight/0.68781679
80MP0001191_abnormal_skin_condition0.68698705
81MP0001727_abnormal_embryo_implantation0.66228537
82MP0000653_abnormal_sex_gland0.65311303
83MP0009931_abnormal_skin_appearance0.64209977
84MP0005310_abnormal_salivary_gland0.63215402
85MP0000569_abnormal_digit_pigmentation0.62327650
86MP0001986_abnormal_taste_sensitivity0.62151076
87MP0002092_abnormal_eye_morphology0.61776115
88MP0002095_abnormal_skin_pigmentation0.60898591
89MP0005647_abnormal_sex_gland0.60639378
90MP0009379_abnormal_foot_pigmentation0.59363874
91MP0004381_abnormal_hair_follicle0.58533839
92MP0005075_abnormal_melanosome_morpholog0.57737805
93MP0005266_abnormal_metabolism0.57208284
94MP0003937_abnormal_limbs/digits/tail_de0.54315971
95MP0010678_abnormal_skin_adnexa0.51713623
96MP0006292_abnormal_olfactory_placode0.50901445
97MP0001286_abnormal_eye_development0.50226092
98MP0000371_diluted_coat_color0.50183235
99MP0008770_decreased_survivor_rate0.50164898
100MP0002083_premature_death0.48672491

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.73034557
2Chromsome breakage (HP:0040012)6.17737779
3IgM deficiency (HP:0002850)4.46490618
4Abnormality of chromosome stability (HP:0003220)4.28849010
5Abnormality of the preputium (HP:0100587)4.07437040
6Aplasia/Hypoplasia of the uvula (HP:0010293)3.97861236
7Colitis (HP:0002583)3.92462888
8IgA deficiency (HP:0002720)3.87092612
9Meckel diverticulum (HP:0002245)3.57963567
10Abnormality of the ileum (HP:0001549)3.48769966
11Microvesicular hepatic steatosis (HP:0001414)3.45022040
12B lymphocytopenia (HP:0010976)3.43995016
13Medulloblastoma (HP:0002885)3.43024954
14Reticulocytopenia (HP:0001896)3.37050137
15Abnormality of the carotid arteries (HP:0005344)3.17272700
16Abnormality of B cell number (HP:0010975)3.15323597
17Small intestinal stenosis (HP:0012848)3.09308986
18Duodenal stenosis (HP:0100867)3.09308986
19Clubbing of toes (HP:0100760)3.05850805
20Abnormality of cells of the erythroid lineage (HP:0012130)3.04909032
21Myelodysplasia (HP:0002863)2.95078500
22Agammaglobulinemia (HP:0004432)2.89001935
23Nephroblastoma (Wilms tumor) (HP:0002667)2.84855293
24Squamous cell carcinoma (HP:0002860)2.77105252
25Birth length less than 3rd percentile (HP:0003561)2.73913847
26Poikilocytosis (HP:0004447)2.69409603
27Oral leukoplakia (HP:0002745)2.68007826
28Abnormal number of erythroid precursors (HP:0012131)2.65226784
29Cellulitis (HP:0100658)2.63770259
30Embryonal renal neoplasm (HP:0011794)2.62963542
31Aplasia/Hypoplasia of the sacrum (HP:0008517)2.56758797
3211 pairs of ribs (HP:0000878)2.47294181
33Abnormality of the duodenum (HP:0002246)2.46134672
34Thyroiditis (HP:0100646)2.43980596
35Colon cancer (HP:0003003)2.38948215
36Abnormality of DNA repair (HP:0003254)2.38711626
37Autoimmune hemolytic anemia (HP:0001890)2.33469985
38Lymphoma (HP:0002665)2.33006893
39Sloping forehead (HP:0000340)2.29653139
40Duplicated collecting system (HP:0000081)2.27516500
41Panhypogammaglobulinemia (HP:0003139)2.24287779
42Abnormality of pyrimidine metabolism (HP:0004353)2.23291566
43Progressive muscle weakness (HP:0003323)2.23203220
44Cafe-au-lait spot (HP:0000957)2.22817158
45Short thumb (HP:0009778)2.21640153
46Prominent nose (HP:0000448)2.21474730
47Recurrent viral infections (HP:0004429)2.20849181
48Abnormality of the renal collecting system (HP:0004742)2.20638306
49Basal cell carcinoma (HP:0002671)2.20102164
50Ectopic kidney (HP:0000086)2.19924654
51Inflammation of the large intestine (HP:0002037)2.19104189
52Bone marrow hypocellularity (HP:0005528)2.18577197
53Acanthocytosis (HP:0001927)2.17024142
54Prostate neoplasm (HP:0100787)2.15131110
55Arteriovenous malformation (HP:0100026)2.13302722
56Absent thumb (HP:0009777)2.12016707
57Hypergonadotropic hypogonadism (HP:0000815)2.11741178
58Progressive external ophthalmoplegia (HP:0000590)2.10277131
59Gastrointestinal inflammation (HP:0004386)2.04731614
60Combined immunodeficiency (HP:0005387)2.04610955
61Rhabdomyosarcoma (HP:0002859)2.02860034
62Abnormality of reticulocytes (HP:0004312)2.00837430
63Abnormality of the fingertips (HP:0001211)2.00270746
64Acute lymphatic leukemia (HP:0006721)1.98964714
65High anterior hairline (HP:0009890)1.96777202
66Viral hepatitis (HP:0006562)1.96119499
67Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.94077691
68Sandal gap (HP:0001852)1.94031955
69Recurrent sinusitis (HP:0011108)1.92326208
70Cellular immunodeficiency (HP:0005374)1.91737499
71Pallor (HP:0000980)1.91014526
72Insomnia (HP:0100785)1.87541735
73Neoplasm of striated muscle (HP:0009728)1.86687312
74Gastrointestinal stroma tumor (HP:0100723)1.85381443
75Tracheoesophageal fistula (HP:0002575)1.84980449
76Abnormality of the prostate (HP:0008775)1.83079413
77Ependymoma (HP:0002888)1.82409126
78Selective tooth agenesis (HP:0001592)1.82089081
79Abnormality of cells of the lymphoid lineage (HP:0012140)1.81930662
80Lymphopenia (HP:0001888)1.81632249
81Abnormality of the heme biosynthetic pathway (HP:0010472)1.81415378
82Poikiloderma (HP:0001029)1.81026928
83Neoplasm of the pancreas (HP:0002894)1.80314135
84Hypoplasia of the pons (HP:0012110)1.80013133
85Leukopenia (HP:0001882)1.79122932
86Multiple enchondromatosis (HP:0005701)1.78796300
87Missing ribs (HP:0000921)1.78071257
88Rough bone trabeculation (HP:0100670)1.77441849
89Neoplasm of the colon (HP:0100273)1.76552137
90Deep philtrum (HP:0002002)1.75646043
91Pancytopenia (HP:0001876)1.71913784
92Severe combined immunodeficiency (HP:0004430)1.70992243
93Abnormality of cochlea (HP:0000375)1.70681982
94External ear malformation (HP:0008572)1.70679277
95Absent radius (HP:0003974)1.70605606
96Carpal bone hypoplasia (HP:0001498)1.69499992
97Abnormality of the pons (HP:0007361)1.67788741
98Embryonal neoplasm (HP:0002898)1.64652428
99Duplication of thumb phalanx (HP:0009942)1.63956535
100Triphalangeal thumb (HP:0001199)1.63948549

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK9.44314141
2TLK18.75742704
3VRK15.14668277
4CDC72.50890667
5STK42.40253797
6DAPK32.35880143
7* RPS6KA52.33985386
8SCYL22.07128966
9BUB11.88090178
10AURKA1.76165986
11AURKB1.57643521
12CHEK21.56508292
13PBK1.46129095
14TTK1.45302478
15PIM11.44806939
16MAP3K101.37341392
17PLK41.31151373
18SRPK11.29962360
19EEF2K1.21220313
20SMG11.17099667
21PKN11.13945191
22BRSK21.08330763
23NEK11.06517184
24TAF11.03929490
25MAP3K81.02675833
26NME20.97158848
27CCNB10.97058268
28ATR0.96997188
29EIF2AK30.93029831
30PLK10.85867018
31RPS6KB20.84649009
32CDK80.83366245
33MST40.83135524
34WEE10.78107586
35BTK0.66256445
36BLK0.63397024
37NEK20.62477106
38MELK0.61076072
39CDK70.60026158
40CDK40.56769750
41CHEK10.54243503
42PRKAA10.53821774
43STK160.53725075
44PLK30.53297515
45VRK20.53091799
46AKT20.52891853
47ATM0.52394567
48MAPK110.51716076
49CDK120.50616296
50TSSK60.48682613
51BRAF0.47502666
52ICK0.42510133
53PIM20.42224666
54BRSK10.40423732
55CDK20.38722757
56TEC0.34422828
57KDR0.33896183
58CDK60.32996711
59PRKCQ0.31269266
60PIK3CG0.31177019
61MAP2K70.30511598
62BCKDK0.30379873
63CDK10.29714737
64PRPF4B0.29571803
65MST1R0.28783341
66SYK0.28516157
67EIF2AK20.27308009
68JAK20.26957687
69NUAK10.26390949
70EIF2AK10.25599119
71PAK10.24830506
72RAF10.23819921
73NLK0.21540800
74CSNK1G10.20909994
75MAP3K40.20479974
76STK30.19854994
77CSNK1G30.19616755
78CSNK2A20.18641416
79NEK90.17572696
80TESK20.16230545
81CSNK1A1L0.15665046
82BMPR1B0.15625216
83CAMK40.14927375
84RPS6KB10.14685116
85RPS6KA40.13816959
86TRIB30.13693232
87MAP2K30.13597965
88LYN0.13369518
89MAPKAPK50.12066028
90PRKDC0.10871032
91MAPK140.10733072
92PRKCI0.10340751
93CDK90.10220121
94BRD40.09461275
95STK100.08505603
96AKT10.08337792
97CSNK2A10.08019977
98PKN20.07863844
99CAMK1D0.07438107
100RPS6KA10.07309404

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050347.64989277
2DNA replication_Homo sapiens_hsa030303.49861557
3Viral carcinogenesis_Homo sapiens_hsa052033.44897349
4Mismatch repair_Homo sapiens_hsa034302.72726230
5* Systemic lupus erythematosus_Homo sapiens_hsa0532210.7515688
6Base excision repair_Homo sapiens_hsa034101.96678291
7Fanconi anemia pathway_Homo sapiens_hsa034601.95598299
8Homologous recombination_Homo sapiens_hsa034401.95296074
9Non-homologous end-joining_Homo sapiens_hsa034501.86724426
10Cell cycle_Homo sapiens_hsa041101.83942781
11Transcriptional misregulation in cancer_Homo sapiens_hsa052021.83602778
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.82736388
13Nucleotide excision repair_Homo sapiens_hsa034201.61184962
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54975006
15Ribosome_Homo sapiens_hsa030101.35965765
16Pyrimidine metabolism_Homo sapiens_hsa002401.16589663
17RNA transport_Homo sapiens_hsa030131.06305593
18RNA polymerase_Homo sapiens_hsa030201.03052813
19Spliceosome_Homo sapiens_hsa030401.01820236
20Primary immunodeficiency_Homo sapiens_hsa053401.00399556
21One carbon pool by folate_Homo sapiens_hsa006700.96176192
22p53 signaling pathway_Homo sapiens_hsa041150.79486598
23Biosynthesis of amino acids_Homo sapiens_hsa012300.65233646
24Pentose phosphate pathway_Homo sapiens_hsa000300.65231149
25Purine metabolism_Homo sapiens_hsa002300.64967602
26Sulfur relay system_Homo sapiens_hsa041220.64233338
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61829824
28Selenocompound metabolism_Homo sapiens_hsa004500.59527288
29Non-small cell lung cancer_Homo sapiens_hsa052230.54884207
30RNA degradation_Homo sapiens_hsa030180.53531640
31mRNA surveillance pathway_Homo sapiens_hsa030150.52990677
32B cell receptor signaling pathway_Homo sapiens_hsa046620.52881802
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50110481
34HTLV-I infection_Homo sapiens_hsa051660.48720059
35Epstein-Barr virus infection_Homo sapiens_hsa051690.45729277
36Intestinal immune network for IgA production_Homo sapiens_hsa046720.45254018
37Pancreatic cancer_Homo sapiens_hsa052120.42885110
38Small cell lung cancer_Homo sapiens_hsa052220.42832089
39Basal transcription factors_Homo sapiens_hsa030220.42816173
40Proteasome_Homo sapiens_hsa030500.42240552
41Thyroid cancer_Homo sapiens_hsa052160.41916533
42Oocyte meiosis_Homo sapiens_hsa041140.40348610
43Herpes simplex infection_Homo sapiens_hsa051680.39980167
44MicroRNAs in cancer_Homo sapiens_hsa052060.39281446
45Chronic myeloid leukemia_Homo sapiens_hsa052200.38237037
46Asthma_Homo sapiens_hsa053100.37664356
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.37618020
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35956735
49Carbon metabolism_Homo sapiens_hsa012000.35340267
50Bladder cancer_Homo sapiens_hsa052190.34034131
51Lysine degradation_Homo sapiens_hsa003100.33486801
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33155401
53Colorectal cancer_Homo sapiens_hsa052100.32268263
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31104339
55Apoptosis_Homo sapiens_hsa042100.29293065
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28080551
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.26909137
58Fructose and mannose metabolism_Homo sapiens_hsa000510.25714957
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25654891
60Glioma_Homo sapiens_hsa052140.25415316
61N-Glycan biosynthesis_Homo sapiens_hsa005100.25265303
62Inositol phosphate metabolism_Homo sapiens_hsa005620.25189676
63Vitamin B6 metabolism_Homo sapiens_hsa007500.24800963
64Hepatitis B_Homo sapiens_hsa051610.22544525
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.21008528
66Huntingtons disease_Homo sapiens_hsa050160.19541933
67Prostate cancer_Homo sapiens_hsa052150.19286567
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.18712608
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.18544131
70Allograft rejection_Homo sapiens_hsa053300.18449529
71Hematopoietic cell lineage_Homo sapiens_hsa046400.17839579
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17279230
73Autoimmune thyroid disease_Homo sapiens_hsa053200.16965703
74TGF-beta signaling pathway_Homo sapiens_hsa043500.16445787
75Melanoma_Homo sapiens_hsa052180.15802034
76Pyruvate metabolism_Homo sapiens_hsa006200.15509264
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15372974
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14786672
79Basal cell carcinoma_Homo sapiens_hsa052170.14517700
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13608716
81Endometrial cancer_Homo sapiens_hsa052130.12938871
82Glutathione metabolism_Homo sapiens_hsa004800.12850715
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12834215
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.10484279
85Galactose metabolism_Homo sapiens_hsa000520.09540120
86Antigen processing and presentation_Homo sapiens_hsa046120.08972430
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.08138812
88Graft-versus-host disease_Homo sapiens_hsa053320.08082429
89Acute myeloid leukemia_Homo sapiens_hsa052210.07921876
90Parkinsons disease_Homo sapiens_hsa050120.07103321
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.06560509
92Measles_Homo sapiens_hsa051620.06513121
93Metabolic pathways_Homo sapiens_hsa011000.05825945
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.04860022
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.04598037
96Arginine biosynthesis_Homo sapiens_hsa002200.04327699
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.04195994
98Influenza A_Homo sapiens_hsa051640.03940258
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.03876218
100HIF-1 signaling pathway_Homo sapiens_hsa040660.03682990

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