

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CENP-A containing nucleosome assembly (GO:0034080) | 5.28485205 |
| 2 | chromatin remodeling at centromere (GO:0031055) | 5.21482106 |
| 3 | DNA replication-dependent nucleosome organization (GO:0034723) | 5.10708897 |
| 4 | DNA replication-dependent nucleosome assembly (GO:0006335) | 5.10708897 |
| 5 | DNA ligation (GO:0006266) | 4.89568514 |
| 6 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.46405901 |
| 7 | histone exchange (GO:0043486) | 4.38473127 |
| 8 | phenylpropanoid metabolic process (GO:0009698) | 4.33950822 |
| 9 | proteasome assembly (GO:0043248) | 4.16564484 |
| 10 | DNA replication checkpoint (GO:0000076) | 4.15431055 |
| 11 | kinetochore organization (GO:0051383) | 4.14148656 |
| 12 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 4.12457016 |
| 13 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.10673284 |
| 14 | regulation of DNA endoreduplication (GO:0032875) | 4.10076257 |
| 15 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.07293679 |
| 16 | NADH dehydrogenase complex assembly (GO:0010257) | 4.07293679 |
| 17 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.07293679 |
| 18 | DNA replication-independent nucleosome assembly (GO:0006336) | 4.03255603 |
| 19 | DNA replication-independent nucleosome organization (GO:0034724) | 4.03255603 |
| 20 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 4.03006413 |
| 21 | mitotic metaphase plate congression (GO:0007080) | 4.02282839 |
| 22 | xenobiotic catabolic process (GO:0042178) | 3.98923476 |
| 23 | protein localization to chromosome, centromeric region (GO:0071459) | 3.96394890 |
| 24 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.91454722 |
| 25 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.91209324 |
| 26 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.89993512 |
| 27 | protein complex biogenesis (GO:0070271) | 3.86256622 |
| 28 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.83814997 |
| 29 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.83331741 |
| 30 | negative regulation of ligase activity (GO:0051352) | 3.74008232 |
| 31 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.74008232 |
| 32 | ATP synthesis coupled proton transport (GO:0015986) | 3.73385742 |
| 33 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.73385742 |
| 34 | kinetochore assembly (GO:0051382) | 3.70705875 |
| 35 | DNA deamination (GO:0045006) | 3.66577305 |
| 36 | pseudouridine synthesis (GO:0001522) | 3.60940387 |
| 37 | mitotic sister chromatid cohesion (GO:0007064) | 3.60608600 |
| 38 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.59905124 |
| 39 | mitotic sister chromatid segregation (GO:0000070) | 3.50512079 |
| 40 | establishment of integrated proviral latency (GO:0075713) | 3.49268538 |
| 41 | spindle checkpoint (GO:0031577) | 3.48078383 |
| 42 | chaperone-mediated protein transport (GO:0072321) | 3.44758042 |
| 43 | metaphase plate congression (GO:0051310) | 3.44261554 |
| 44 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.40308490 |
| 45 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.40120469 |
| 46 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.39883171 |
| 47 | protein localization to kinetochore (GO:0034501) | 3.38856686 |
| 48 | ribosome biogenesis (GO:0042254) | 3.35882999 |
| 49 | viral mRNA export from host cell nucleus (GO:0046784) | 3.32239329 |
| 50 | sister chromatid segregation (GO:0000819) | 3.30816045 |
| 51 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.27255810 |
| 52 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.25577859 |
| 53 | regulation of centrosome cycle (GO:0046605) | 3.24864824 |
| 54 | positive regulation of ligase activity (GO:0051351) | 3.23727751 |
| 55 | respiratory chain complex IV assembly (GO:0008535) | 3.23623557 |
| 56 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.21025799 |
| 57 | DNA topological change (GO:0006265) | 3.20423207 |
| 58 | histone-serine phosphorylation (GO:0035404) | 3.19886740 |
| 59 | chromatin assembly or disassembly (GO:0006333) | 3.18359141 |
| 60 | mitotic spindle checkpoint (GO:0071174) | 3.17238405 |
| 61 | DNA strand elongation (GO:0022616) | 3.16353427 |
| 62 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.15459864 |
| 63 | ATP-dependent chromatin remodeling (GO:0043044) | 3.14188490 |
| 64 | mitotic chromosome condensation (GO:0007076) | 3.13635975 |
| 65 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.12938657 |
| 66 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.12101488 |
| 67 | establishment of chromosome localization (GO:0051303) | 3.12051285 |
| 68 | rRNA catabolic process (GO:0016075) | 3.11431205 |
| 69 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.09438834 |
| 70 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.09438834 |
| 71 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.09438834 |
| 72 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.09438834 |
| 73 | negative regulation of sister chromatid segregation (GO:0033046) | 3.09438834 |
| 74 | mitotic G2/M transition checkpoint (GO:0044818) | 3.09033599 |
| 75 | protein localization to chromosome (GO:0034502) | 3.08554982 |
| 76 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.08508555 |
| 77 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.08508555 |
| 78 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.07968811 |
| 79 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.07968811 |
| 80 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.07968811 |
| 81 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.07683114 |
| 82 | replication fork processing (GO:0031297) | 3.07318580 |
| 83 | synapsis (GO:0007129) | 3.06431057 |
| 84 | negative regulation of chromosome segregation (GO:0051985) | 3.04517726 |
| 85 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.03873353 |
| 86 | regulation of ligase activity (GO:0051340) | 3.02861483 |
| 87 | DNA damage response, detection of DNA damage (GO:0042769) | 3.02593047 |
| 88 | cellular component biogenesis (GO:0044085) | 3.01680405 |
| 89 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.01477701 |
| 90 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.01477701 |
| 91 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.00257681 |
| 92 | regulation of chromosome segregation (GO:0051983) | 3.00054308 |
| 93 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.99221911 |
| 94 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.97128796 |
| 95 | protein deneddylation (GO:0000338) | 2.97046205 |
| 96 | V(D)J recombination (GO:0033151) | 2.94528058 |
| 97 | mitotic spindle assembly checkpoint (GO:0007094) | 2.91777155 |
| 98 | postreplication repair (GO:0006301) | 2.91200322 |
| 99 | spindle assembly checkpoint (GO:0071173) | 2.90902490 |
| 100 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 2.90603005 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.84756211 |
| 2 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 5.55155045 |
| 3 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 5.08856464 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.67506387 |
| 5 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.63603799 |
| 6 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.34026481 |
| 7 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.90441431 |
| 8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.65536302 |
| 9 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.49397396 |
| 10 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 3.37105210 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.22790647 |
| 12 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.20951932 |
| 13 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.08898430 |
| 14 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.84480139 |
| 15 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.76675578 |
| 16 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.70862225 |
| 17 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.66035181 |
| 18 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.63890915 |
| 19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.53074426 |
| 20 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.46082206 |
| 21 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.41870179 |
| 22 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.41038752 |
| 23 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.38286114 |
| 24 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.37979265 |
| 25 | VDR_22108803_ChIP-Seq_LS180_Human | 2.36299417 |
| 26 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.32876707 |
| 27 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.22952262 |
| 28 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.22327009 |
| 29 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.21693225 |
| 30 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.20829057 |
| 31 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.18536678 |
| 32 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.17823033 |
| 33 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.16422089 |
| 34 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.05147131 |
| 35 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.01859653 |
| 36 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.99424517 |
| 37 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.93979487 |
| 38 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.85981678 |
| 39 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.82568205 |
| 40 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.80268245 |
| 41 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.79301803 |
| 42 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.77066580 |
| 43 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.74149043 |
| 44 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.72465683 |
| 45 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.69391273 |
| 46 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.65915092 |
| 47 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.62306347 |
| 48 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.62100213 |
| 49 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.61991720 |
| 50 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.59032674 |
| 51 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.57163947 |
| 52 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.56233221 |
| 53 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.55654380 |
| 54 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.44566985 |
| 55 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.43610490 |
| 56 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.38464700 |
| 57 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.32675944 |
| 58 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.29034669 |
| 59 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.23747018 |
| 60 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.20694093 |
| 61 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.20270353 |
| 62 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.17420635 |
| 63 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.14285205 |
| 64 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.13875997 |
| 65 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.13416296 |
| 66 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.12475275 |
| 67 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.11054655 |
| 68 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.10612278 |
| 69 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.09229313 |
| 70 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.08495870 |
| 71 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.08268980 |
| 72 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.07142923 |
| 73 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.05631915 |
| 74 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.05207864 |
| 75 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.02997968 |
| 76 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.00519133 |
| 77 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.96120875 |
| 78 | EWS_26573619_Chip-Seq_HEK293_Human | 0.95098407 |
| 79 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.93822836 |
| 80 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.91844743 |
| 81 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.90560867 |
| 82 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.89719179 |
| 83 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.89105537 |
| 84 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.88398096 |
| 85 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.87294219 |
| 86 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.84890432 |
| 87 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.82260653 |
| 88 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.80660085 |
| 89 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.79244255 |
| 90 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.76338591 |
| 91 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.74159441 |
| 92 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.72860476 |
| 93 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.72302215 |
| 94 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.69390870 |
| 95 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.69242225 |
| 96 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.66622335 |
| 97 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.64717435 |
| 98 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.58323026 |
| 99 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.57051936 |
| 100 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.56734958 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.43605927 |
| 2 | MP0010094_abnormal_chromosome_stability | 5.21842385 |
| 3 | MP0008058_abnormal_DNA_repair | 4.34977821 |
| 4 | MP0003111_abnormal_nucleus_morphology | 4.32518754 |
| 5 | MP0004957_abnormal_blastocyst_morpholog | 4.13492263 |
| 6 | MP0003077_abnormal_cell_cycle | 3.38299525 |
| 7 | MP0003718_maternal_effect | 2.98155338 |
| 8 | MP0008007_abnormal_cellular_replicative | 2.77533404 |
| 9 | MP0009697_abnormal_copulation | 2.76825996 |
| 10 | MP0008789_abnormal_olfactory_epithelium | 2.70394370 |
| 11 | MP0008932_abnormal_embryonic_tissue | 2.69156865 |
| 12 | MP0002938_white_spotting | 2.65101969 |
| 13 | MP0003806_abnormal_nucleotide_metabolis | 2.48791740 |
| 14 | MP0003786_premature_aging | 2.44452565 |
| 15 | MP0008877_abnormal_DNA_methylation | 2.41841562 |
| 16 | MP0006035_abnormal_mitochondrial_morpho | 2.31714719 |
| 17 | MP0006292_abnormal_olfactory_placode | 2.16210226 |
| 18 | MP0001529_abnormal_vocalization | 2.05724184 |
| 19 | MP0008057_abnormal_DNA_replication | 2.04327198 |
| 20 | MP0010307_abnormal_tumor_latency | 1.83406764 |
| 21 | MP0006036_abnormal_mitochondrial_physio | 1.81557733 |
| 22 | MP0005171_absent_coat_pigmentation | 1.77568240 |
| 23 | MP0001293_anophthalmia | 1.76572111 |
| 24 | MP0001661_extended_life_span | 1.71032224 |
| 25 | MP0003186_abnormal_redox_activity | 1.69892136 |
| 26 | MP0003941_abnormal_skin_development | 1.62503180 |
| 27 | MP0009384_cardiac_valve_regurgitation | 1.54507735 |
| 28 | MP0000049_abnormal_middle_ear | 1.53746095 |
| 29 | MP0005083_abnormal_biliary_tract | 1.52304140 |
| 30 | MP0006072_abnormal_retinal_apoptosis | 1.51639819 |
| 31 | MP0005394_taste/olfaction_phenotype | 1.46359179 |
| 32 | MP0005499_abnormal_olfactory_system | 1.46359179 |
| 33 | MP0000313_abnormal_cell_death | 1.41105535 |
| 34 | MP0005503_abnormal_tendon_morphology | 1.39280992 |
| 35 | MP0001929_abnormal_gametogenesis | 1.36989357 |
| 36 | MP0000350_abnormal_cell_proliferation | 1.36531309 |
| 37 | MP0001485_abnormal_pinna_reflex | 1.32194723 |
| 38 | MP0004134_abnormal_chest_morphology | 1.30256620 |
| 39 | MP0001697_abnormal_embryo_size | 1.28920298 |
| 40 | MP0009379_abnormal_foot_pigmentation | 1.27179950 |
| 41 | MP0000358_abnormal_cell_content/ | 1.26357602 |
| 42 | MP0003937_abnormal_limbs/digits/tail_de | 1.24720626 |
| 43 | MP0005075_abnormal_melanosome_morpholog | 1.23947583 |
| 44 | MP0000516_abnormal_urinary_system | 1.23434484 |
| 45 | MP0005367_renal/urinary_system_phenotyp | 1.23434484 |
| 46 | MP0010030_abnormal_orbit_morphology | 1.22768846 |
| 47 | MP0002210_abnormal_sex_determination | 1.20015192 |
| 48 | MP0002160_abnormal_reproductive_system | 1.19456635 |
| 49 | MP0001119_abnormal_female_reproductive | 1.19115232 |
| 50 | MP0001145_abnormal_male_reproductive | 1.12599590 |
| 51 | MP0005084_abnormal_gallbladder_morpholo | 1.10509444 |
| 52 | MP0000653_abnormal_sex_gland | 1.07140297 |
| 53 | MP0002019_abnormal_tumor_incidence | 1.03265799 |
| 54 | MP0004147_increased_porphyrin_level | 1.03234043 |
| 55 | MP0002080_prenatal_lethality | 1.00450838 |
| 56 | MP0005395_other_phenotype | 0.94352704 |
| 57 | MP0002085_abnormal_embryonic_tissue | 0.93337221 |
| 58 | MP0001177_atelectasis | 0.92318119 |
| 59 | MP0005380_embryogenesis_phenotype | 0.92126450 |
| 60 | MP0001672_abnormal_embryogenesis/_devel | 0.92126450 |
| 61 | MP0002111_abnormal_tail_morphology | 0.91643842 |
| 62 | MP0005253_abnormal_eye_physiology | 0.88492038 |
| 63 | MP0009053_abnormal_anal_canal | 0.84391522 |
| 64 | MP0001730_embryonic_growth_arrest | 0.83497845 |
| 65 | MP0001853_heart_inflammation | 0.83143820 |
| 66 | MP0004197_abnormal_fetal_growth/weight/ | 0.82828232 |
| 67 | MP0003699_abnormal_female_reproductive | 0.82822424 |
| 68 | MP0000372_irregular_coat_pigmentation | 0.80548712 |
| 69 | MP0003011_delayed_dark_adaptation | 0.78295051 |
| 70 | MP0002396_abnormal_hematopoietic_system | 0.77477036 |
| 71 | MP0005389_reproductive_system_phenotype | 0.74895366 |
| 72 | MP0002006_tumorigenesis | 0.73350407 |
| 73 | MP0002095_abnormal_skin_pigmentation | 0.73323954 |
| 74 | MP0003984_embryonic_growth_retardation | 0.72974499 |
| 75 | MP0003119_abnormal_digestive_system | 0.72317493 |
| 76 | MP0004215_abnormal_myocardial_fiber | 0.71812209 |
| 77 | MP0003890_abnormal_embryonic-extraembry | 0.71463348 |
| 78 | MP0001286_abnormal_eye_development | 0.71333237 |
| 79 | MP0002088_abnormal_embryonic_growth/wei | 0.69892201 |
| 80 | MP0009672_abnormal_birth_weight | 0.69239572 |
| 81 | MP0000631_abnormal_neuroendocrine_gland | 0.67412546 |
| 82 | MP0002161_abnormal_fertility/fecundity | 0.66092390 |
| 83 | MP0000703_abnormal_thymus_morphology | 0.65873452 |
| 84 | MP0002089_abnormal_postnatal_growth/wei | 0.65051210 |
| 85 | MP0005379_endocrine/exocrine_gland_phen | 0.63549051 |
| 86 | MP0002233_abnormal_nose_morphology | 0.62828473 |
| 87 | MP0002084_abnormal_developmental_patter | 0.61427843 |
| 88 | MP0003698_abnormal_male_reproductive | 0.61336544 |
| 89 | MP0002086_abnormal_extraembryonic_tissu | 0.60705105 |
| 90 | MP0003936_abnormal_reproductive_system | 0.60389133 |
| 91 | MP0002796_impaired_skin_barrier | 0.56704279 |
| 92 | MP0002102_abnormal_ear_morphology | 0.56452956 |
| 93 | MP0005391_vision/eye_phenotype | 0.56194937 |
| 94 | MP0008872_abnormal_physiological_respon | 0.55568150 |
| 95 | MP0005501_abnormal_skin_physiology | 0.53365568 |
| 96 | MP0002722_abnormal_immune_system | 0.52359064 |
| 97 | MP0002751_abnormal_autonomic_nervous | 0.51110188 |
| 98 | MP0009333_abnormal_splenocyte_physiolog | 0.50850951 |
| 99 | MP0000428_abnormal_craniofacial_morphol | 0.50522676 |
| 100 | MP0005671_abnormal_response_to | 0.49095391 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 3.98599137 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.68413120 |
| 3 | Acute encephalopathy (HP:0006846) | 3.59814080 |
| 4 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.55283421 |
| 5 | Increased CSF lactate (HP:0002490) | 3.54239783 |
| 6 | Abnormality of the labia minora (HP:0012880) | 3.52882534 |
| 7 | Mitochondrial inheritance (HP:0001427) | 3.51270441 |
| 8 | Chromsome breakage (HP:0040012) | 3.17439450 |
| 9 | Progressive macrocephaly (HP:0004481) | 3.17267409 |
| 10 | Hepatocellular necrosis (HP:0001404) | 3.12634039 |
| 11 | Abnormal number of erythroid precursors (HP:0012131) | 3.10387293 |
| 12 | Increased serum pyruvate (HP:0003542) | 3.06522061 |
| 13 | Aplastic anemia (HP:0001915) | 3.02613167 |
| 14 | Medulloblastoma (HP:0002885) | 3.01589728 |
| 15 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.01145778 |
| 16 | Abnormality of the ileum (HP:0001549) | 2.97722285 |
| 17 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.95784037 |
| 18 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.95784037 |
| 19 | Birth length less than 3rd percentile (HP:0003561) | 2.93536979 |
| 20 | Abnormality of the carotid arteries (HP:0005344) | 2.92486303 |
| 21 | Abnormality of chromosome stability (HP:0003220) | 2.89540963 |
| 22 | Abnormality of alanine metabolism (HP:0010916) | 2.87116448 |
| 23 | Hyperalaninemia (HP:0003348) | 2.87116448 |
| 24 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.87116448 |
| 25 | Cerebral edema (HP:0002181) | 2.86352799 |
| 26 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.83379933 |
| 27 | Hepatic necrosis (HP:0002605) | 2.83115250 |
| 28 | Meckel diverticulum (HP:0002245) | 2.77533958 |
| 29 | Abnormality of the preputium (HP:0100587) | 2.70174695 |
| 30 | Absent radius (HP:0003974) | 2.63633567 |
| 31 | Increased serum lactate (HP:0002151) | 2.57682295 |
| 32 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.57362410 |
| 33 | Short thumb (HP:0009778) | 2.55964877 |
| 34 | Bilateral microphthalmos (HP:0007633) | 2.54615342 |
| 35 | Short phalanx of the thumb (HP:0009660) | 2.52300887 |
| 36 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.51222396 |
| 37 | Short 4th metacarpal (HP:0010044) | 2.51222396 |
| 38 | Abnormality of glycolysis (HP:0004366) | 2.49199463 |
| 39 | Abnormal lung lobation (HP:0002101) | 2.48487649 |
| 40 | Absent forearm bone (HP:0003953) | 2.48263783 |
| 41 | Aplasia involving forearm bones (HP:0009822) | 2.48263783 |
| 42 | Median cleft lip (HP:0000161) | 2.45999816 |
| 43 | Abnormal number of incisors (HP:0011064) | 2.45121974 |
| 44 | Stenosis of the external auditory canal (HP:0000402) | 2.44468775 |
| 45 | Embryonal renal neoplasm (HP:0011794) | 2.43577726 |
| 46 | Increased hepatocellular lipid droplets (HP:0006565) | 2.41886959 |
| 47 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.41687103 |
| 48 | Volvulus (HP:0002580) | 2.34542589 |
| 49 | Absent thumb (HP:0009777) | 2.33437061 |
| 50 | Abnormality of the nasal septum (HP:0000419) | 2.31440570 |
| 51 | Optic nerve coloboma (HP:0000588) | 2.30729700 |
| 52 | Small intestinal stenosis (HP:0012848) | 2.29432467 |
| 53 | Duodenal stenosis (HP:0100867) | 2.29432467 |
| 54 | Neoplasm of the oral cavity (HP:0100649) | 2.29134954 |
| 55 | Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658) | 2.28137846 |
| 56 | Patellar aplasia (HP:0006443) | 2.25318761 |
| 57 | Oligodactyly (HP:0012165) | 2.23956166 |
| 58 | Oligodactyly (hands) (HP:0001180) | 2.23406131 |
| 59 | Spinal muscular atrophy (HP:0007269) | 2.23131675 |
| 60 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.19987905 |
| 61 | Horseshoe kidney (HP:0000085) | 2.19134574 |
| 62 | Lipid accumulation in hepatocytes (HP:0006561) | 2.18291486 |
| 63 | Cleft eyelid (HP:0000625) | 2.15561144 |
| 64 | Congenital, generalized hypertrichosis (HP:0004540) | 2.14896690 |
| 65 | Oral leukoplakia (HP:0002745) | 2.14244150 |
| 66 | Triphalangeal thumb (HP:0001199) | 2.14090337 |
| 67 | Lactic acidosis (HP:0003128) | 2.13578632 |
| 68 | Myelodysplasia (HP:0002863) | 2.13493588 |
| 69 | Abnormality of serum amino acid levels (HP:0003112) | 2.11310623 |
| 70 | Clubbing of toes (HP:0100760) | 2.09161404 |
| 71 | Abnormality of the duodenum (HP:0002246) | 2.09021165 |
| 72 | Colon cancer (HP:0003003) | 2.08391787 |
| 73 | Respiratory failure (HP:0002878) | 2.05942304 |
| 74 | Depressed nasal tip (HP:0000437) | 2.04577455 |
| 75 | Leukodystrophy (HP:0002415) | 2.04431225 |
| 76 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.99260715 |
| 77 | Intestinal atresia (HP:0011100) | 1.98997961 |
| 78 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.98947566 |
| 79 | 3-Methylglutaconic aciduria (HP:0003535) | 1.97133097 |
| 80 | Multiple enchondromatosis (HP:0005701) | 1.96916150 |
| 81 | Facial hemangioma (HP:0000329) | 1.95775051 |
| 82 | Abnormal protein glycosylation (HP:0012346) | 1.92519692 |
| 83 | Abnormal glycosylation (HP:0012345) | 1.92519692 |
| 84 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.92519692 |
| 85 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.92519692 |
| 86 | Aplasia/hypoplasia of the humerus (HP:0006507) | 1.91408499 |
| 87 | B lymphocytopenia (HP:0010976) | 1.90426063 |
| 88 | Rectal fistula (HP:0100590) | 1.89805546 |
| 89 | Rectovaginal fistula (HP:0000143) | 1.89805546 |
| 90 | Carpal bone hypoplasia (HP:0001498) | 1.89231857 |
| 91 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.87748130 |
| 92 | Abnormality of the anterior horn cell (HP:0006802) | 1.86411328 |
| 93 | Degeneration of anterior horn cells (HP:0002398) | 1.86411328 |
| 94 | Meningioma (HP:0002858) | 1.85974039 |
| 95 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.82700407 |
| 96 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.82700407 |
| 97 | Hypoplasia of the pons (HP:0012110) | 1.82296862 |
| 98 | CNS demyelination (HP:0007305) | 1.81853346 |
| 99 | Abnormality of B cell number (HP:0010975) | 1.81550147 |
| 100 | Optic disc pallor (HP:0000543) | 1.80064927 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ZAK | 4.98930706 |
| 2 | TLK1 | 4.78978191 |
| 3 | BUB1 | 4.43422682 |
| 4 | VRK1 | 4.15255978 |
| 5 | CDC7 | 3.00375000 |
| 6 | VRK2 | 3.00063943 |
| 7 | PBK | 2.98149586 |
| 8 | MST4 | 2.53463691 |
| 9 | EIF2AK1 | 2.50138179 |
| 10 | NEK1 | 2.46481496 |
| 11 | TSSK6 | 2.44555709 |
| 12 | NUAK1 | 2.36212141 |
| 13 | BCKDK | 2.27958945 |
| 14 | MKNK2 | 2.25854350 |
| 15 | PLK3 | 2.06478336 |
| 16 | CCNB1 | 2.03287498 |
| 17 | BRSK2 | 1.92618687 |
| 18 | TTK | 1.85810533 |
| 19 | WEE1 | 1.85039898 |
| 20 | PLK4 | 1.83287363 |
| 21 | AURKA | 1.75509333 |
| 22 | BRSK1 | 1.72169769 |
| 23 | EIF2AK3 | 1.71244306 |
| 24 | SRPK1 | 1.71227849 |
| 25 | TAF1 | 1.69126694 |
| 26 | PLK1 | 1.64801078 |
| 27 | NME2 | 1.63561323 |
| 28 | EPHA3 | 1.55441584 |
| 29 | AURKB | 1.49702523 |
| 30 | ADRBK2 | 1.40030350 |
| 31 | PDK2 | 1.38279991 |
| 32 | ATR | 1.36078779 |
| 33 | MKNK1 | 1.35858042 |
| 34 | STK16 | 1.13888044 |
| 35 | RPS6KA5 | 1.13777572 |
| 36 | TAOK3 | 1.00396328 |
| 37 | NME1 | 0.99281801 |
| 38 | PIM2 | 0.94899494 |
| 39 | PIK3CA | 0.91519634 |
| 40 | CHEK2 | 0.90711226 |
| 41 | STK4 | 0.90469658 |
| 42 | MAP4K2 | 0.88325210 |
| 43 | CHEK1 | 0.83045426 |
| 44 | EIF2AK2 | 0.78974593 |
| 45 | TESK2 | 0.76746439 |
| 46 | DAPK3 | 0.67792387 |
| 47 | RAF1 | 0.67025240 |
| 48 | LATS1 | 0.65979295 |
| 49 | ACVR1B | 0.65973119 |
| 50 | MAP3K8 | 0.65152128 |
| 51 | TRIM28 | 0.65032421 |
| 52 | PRKCI | 0.62302498 |
| 53 | CSNK2A1 | 0.62104096 |
| 54 | PIM1 | 0.61831200 |
| 55 | MAP3K9 | 0.60020140 |
| 56 | STK10 | 0.59575551 |
| 57 | ATM | 0.56523447 |
| 58 | NEK6 | 0.55778462 |
| 59 | PLK2 | 0.55086859 |
| 60 | GRK1 | 0.55040972 |
| 61 | CDK9 | 0.53310000 |
| 62 | BMPR1B | 0.53058632 |
| 63 | CLK1 | 0.50819707 |
| 64 | CSNK2A2 | 0.46232225 |
| 65 | NEK2 | 0.44165149 |
| 66 | CDK7 | 0.43247180 |
| 67 | TIE1 | 0.42561082 |
| 68 | KDR | 0.41394129 |
| 69 | CDK1 | 0.38960756 |
| 70 | WNK3 | 0.38140133 |
| 71 | CDK2 | 0.37128974 |
| 72 | DYRK2 | 0.34693277 |
| 73 | ABL2 | 0.34224464 |
| 74 | PKN1 | 0.33791882 |
| 75 | MARK3 | 0.31939670 |
| 76 | MELK | 0.31874150 |
| 77 | CSNK1G1 | 0.30835180 |
| 78 | RPS6KB1 | 0.28247654 |
| 79 | PAK1 | 0.25914677 |
| 80 | IKBKB | 0.25007754 |
| 81 | ERBB3 | 0.24035023 |
| 82 | CSNK1G3 | 0.23602385 |
| 83 | ALK | 0.21656050 |
| 84 | CDK4 | 0.21282949 |
| 85 | DAPK1 | 0.19481896 |
| 86 | PRKDC | 0.19034804 |
| 87 | CDK18 | 0.18154783 |
| 88 | FGFR1 | 0.16643145 |
| 89 | CDK15 | 0.15983822 |
| 90 | CSNK1G2 | 0.14488307 |
| 91 | RPS6KB2 | 0.13912927 |
| 92 | CSNK1A1L | 0.12950500 |
| 93 | ADRBK1 | 0.12065824 |
| 94 | GSK3A | 0.11835542 |
| 95 | RPS6KA4 | 0.11726125 |
| 96 | CSNK1E | 0.11451252 |
| 97 | DYRK3 | 0.11442604 |
| 98 | CDK14 | 0.10872416 |
| 99 | CSNK1A1 | 0.10739240 |
| 100 | PNCK | 0.10415505 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.85778271 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 4.01887960 |
| 3 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 3.57267221 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 3.35165575 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.30884635 |
| 6 | Homologous recombination_Homo sapiens_hsa03440 | 3.06273522 |
| 7 | Mismatch repair_Homo sapiens_hsa03430 | 2.98006741 |
| 8 | Base excision repair_Homo sapiens_hsa03410 | 2.79780255 |
| 9 | RNA polymerase_Homo sapiens_hsa03020 | 2.75605579 |
| 10 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.74706213 |
| 11 | Parkinsons disease_Homo sapiens_hsa05012 | 2.70535263 |
| 12 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.49942024 |
| 13 | Spliceosome_Homo sapiens_hsa03040 | 2.34566851 |
| 14 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.29610500 |
| 15 | Cell cycle_Homo sapiens_hsa04110 | 2.16769334 |
| 16 | Protein export_Homo sapiens_hsa03060 | 2.11859331 |
| 17 | Alcoholism_Homo sapiens_hsa05034 | 2.09415351 |
| 18 | Huntingtons disease_Homo sapiens_hsa05016 | 2.01425740 |
| 19 | RNA degradation_Homo sapiens_hsa03018 | 1.95339067 |
| 20 | RNA transport_Homo sapiens_hsa03013 | 1.90670370 |
| 21 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.86066226 |
| 22 | Basal transcription factors_Homo sapiens_hsa03022 | 1.79055430 |
| 23 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.65379421 |
| 24 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.56489266 |
| 25 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.53480034 |
| 26 | Alzheimers disease_Homo sapiens_hsa05010 | 1.50338777 |
| 27 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.44953014 |
| 28 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.32420557 |
| 29 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.25566080 |
| 30 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.22542321 |
| 31 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.22507891 |
| 32 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.18063013 |
| 33 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.17993395 |
| 34 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.14183151 |
| 35 | Purine metabolism_Homo sapiens_hsa00230 | 1.13964706 |
| 36 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.09148122 |
| 37 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.04925992 |
| 38 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.03935921 |
| 39 | Sulfur relay system_Homo sapiens_hsa04122 | 1.02416947 |
| 40 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.02261874 |
| 41 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.99374218 |
| 42 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.97462922 |
| 43 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.97263328 |
| 44 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.90690573 |
| 45 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.86740046 |
| 46 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.78757307 |
| 47 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.75389842 |
| 48 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.72544904 |
| 49 | Peroxisome_Homo sapiens_hsa04146 | 0.69180596 |
| 50 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.67708797 |
| 51 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.67279260 |
| 52 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.66686439 |
| 53 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.59897032 |
| 54 | Asthma_Homo sapiens_hsa05310 | 0.56183549 |
| 55 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.55825719 |
| 56 | Carbon metabolism_Homo sapiens_hsa01200 | 0.54496369 |
| 57 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.54455150 |
| 58 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.52398365 |
| 59 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.52109611 |
| 60 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.51927145 |
| 61 | Metabolic pathways_Homo sapiens_hsa01100 | 0.50804228 |
| 62 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.48029955 |
| 63 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.46455497 |
| 64 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.46409126 |
| 65 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.46099714 |
| 66 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.45025443 |
| 67 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.43070414 |
| 68 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.41955999 |
| 69 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.38931926 |
| 70 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.37947277 |
| 71 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.37369295 |
| 72 | HTLV-I infection_Homo sapiens_hsa05166 | 0.33766137 |
| 73 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.31389333 |
| 74 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.30159473 |
| 75 | Mineral absorption_Homo sapiens_hsa04978 | 0.29051677 |
| 76 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.25821613 |
| 77 | Legionellosis_Homo sapiens_hsa05134 | 0.23228559 |
| 78 | Retinol metabolism_Homo sapiens_hsa00830 | 0.22673657 |
| 79 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.22390153 |
| 80 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.21631654 |
| 81 | Histidine metabolism_Homo sapiens_hsa00340 | 0.21403764 |
| 82 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.20887459 |
| 83 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.19353823 |
| 84 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.19213176 |
| 85 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.18076142 |
| 86 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.17120061 |
| 87 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.15845290 |
| 88 | Bladder cancer_Homo sapiens_hsa05219 | 0.15442689 |
| 89 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.15064593 |
| 90 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.14779387 |
| 91 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.13918050 |
| 92 | Phototransduction_Homo sapiens_hsa04744 | 0.12876051 |
| 93 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.12532528 |
| 94 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.10796958 |
| 95 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.09672444 |
| 96 | Allograft rejection_Homo sapiens_hsa05330 | 0.08364269 |
| 97 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.07899829 |
| 98 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.07327094 |
| 99 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.06370722 |
| 100 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.05394311 |

