HIST1H2APS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1CENP-A containing nucleosome assembly (GO:0034080)5.28485205
2chromatin remodeling at centromere (GO:0031055)5.21482106
3DNA replication-dependent nucleosome organization (GO:0034723)5.10708897
4DNA replication-dependent nucleosome assembly (GO:0006335)5.10708897
5DNA ligation (GO:0006266)4.89568514
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.46405901
7histone exchange (GO:0043486)4.38473127
8phenylpropanoid metabolic process (GO:0009698)4.33950822
9proteasome assembly (GO:0043248)4.16564484
10DNA replication checkpoint (GO:0000076)4.15431055
11kinetochore organization (GO:0051383)4.14148656
12nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.12457016
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.10673284
14regulation of DNA endoreduplication (GO:0032875)4.10076257
15mitochondrial respiratory chain complex I assembly (GO:0032981)4.07293679
16NADH dehydrogenase complex assembly (GO:0010257)4.07293679
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.07293679
18DNA replication-independent nucleosome assembly (GO:0006336)4.03255603
19DNA replication-independent nucleosome organization (GO:0034724)4.03255603
20exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.03006413
21mitotic metaphase plate congression (GO:0007080)4.02282839
22xenobiotic catabolic process (GO:0042178)3.98923476
23protein localization to chromosome, centromeric region (GO:0071459)3.96394890
24mitochondrial respiratory chain complex assembly (GO:0033108)3.91454722
25anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.91209324
26regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.89993512
27protein complex biogenesis (GO:0070271)3.86256622
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.83814997
29establishment of protein localization to mitochondrial membrane (GO:0090151)3.83331741
30negative regulation of ligase activity (GO:0051352)3.74008232
31negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.74008232
32ATP synthesis coupled proton transport (GO:0015986)3.73385742
33energy coupled proton transport, down electrochemical gradient (GO:0015985)3.73385742
34kinetochore assembly (GO:0051382)3.70705875
35DNA deamination (GO:0045006)3.66577305
36pseudouridine synthesis (GO:0001522)3.60940387
37mitotic sister chromatid cohesion (GO:0007064)3.60608600
38regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.59905124
39mitotic sister chromatid segregation (GO:0000070)3.50512079
40establishment of integrated proviral latency (GO:0075713)3.49268538
41spindle checkpoint (GO:0031577)3.48078383
42chaperone-mediated protein transport (GO:0072321)3.44758042
43metaphase plate congression (GO:0051310)3.44261554
44negative regulation of DNA-dependent DNA replication (GO:2000104)3.40308490
45telomere maintenance via semi-conservative replication (GO:0032201)3.40120469
46positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.39883171
47protein localization to kinetochore (GO:0034501)3.38856686
48ribosome biogenesis (GO:0042254)3.35882999
49viral mRNA export from host cell nucleus (GO:0046784)3.32239329
50sister chromatid segregation (GO:0000819)3.30816045
51regulation of cellular amino acid metabolic process (GO:0006521)3.27255810
52DNA strand elongation involved in DNA replication (GO:0006271)3.25577859
53regulation of centrosome cycle (GO:0046605)3.24864824
54positive regulation of ligase activity (GO:0051351)3.23727751
55respiratory chain complex IV assembly (GO:0008535)3.23623557
56regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.21025799
57DNA topological change (GO:0006265)3.20423207
58histone-serine phosphorylation (GO:0035404)3.19886740
59chromatin assembly or disassembly (GO:0006333)3.18359141
60mitotic spindle checkpoint (GO:0071174)3.17238405
61DNA strand elongation (GO:0022616)3.16353427
62regulation of ubiquitin-protein transferase activity (GO:0051438)3.15459864
63ATP-dependent chromatin remodeling (GO:0043044)3.14188490
64mitotic chromosome condensation (GO:0007076)3.13635975
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.12938657
66attachment of spindle microtubules to kinetochore (GO:0008608)3.12101488
67establishment of chromosome localization (GO:0051303)3.12051285
68rRNA catabolic process (GO:0016075)3.11431205
69negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.09438834
70negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.09438834
71negative regulation of mitotic sister chromatid segregation (GO:0033048)3.09438834
72negative regulation of mitotic sister chromatid separation (GO:2000816)3.09438834
73negative regulation of sister chromatid segregation (GO:0033046)3.09438834
74mitotic G2/M transition checkpoint (GO:0044818)3.09033599
75protein localization to chromosome (GO:0034502)3.08554982
76signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.08508555
77intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.08508555
78signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.07968811
79signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.07968811
80signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.07968811
81mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.07683114
82replication fork processing (GO:0031297)3.07318580
83synapsis (GO:0007129)3.06431057
84negative regulation of chromosome segregation (GO:0051985)3.04517726
85deoxyribonucleotide biosynthetic process (GO:0009263)3.03873353
86regulation of ligase activity (GO:0051340)3.02861483
87DNA damage response, detection of DNA damage (GO:0042769)3.02593047
88cellular component biogenesis (GO:0044085)3.01680405
89signal transduction involved in DNA damage checkpoint (GO:0072422)3.01477701
90signal transduction involved in DNA integrity checkpoint (GO:0072401)3.01477701
91maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.00257681
92regulation of chromosome segregation (GO:0051983)3.00054308
93RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.99221911
94signal transduction involved in cell cycle checkpoint (GO:0072395)2.97128796
95protein deneddylation (GO:0000338)2.97046205
96V(D)J recombination (GO:0033151)2.94528058
97mitotic spindle assembly checkpoint (GO:0007094)2.91777155
98postreplication repair (GO:0006301)2.91200322
99spindle assembly checkpoint (GO:0071173)2.90902490
100regulation of double-strand break repair via homologous recombination (GO:0010569)2.90603005

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.84756211
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.55155045
3E2F4_17652178_ChIP-ChIP_JURKAT_Human5.08856464
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.67506387
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.63603799
6FOXM1_23109430_ChIP-Seq_U2OS_Human4.34026481
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.90441431
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.65536302
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.49397396
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.37105210
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.22790647
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.20951932
13MYC_18555785_ChIP-Seq_MESCs_Mouse3.08898430
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.84480139
15ELK1_19687146_ChIP-ChIP_HELA_Human2.76675578
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.70862225
17VDR_23849224_ChIP-Seq_CD4+_Human2.66035181
18AR_21909140_ChIP-Seq_LNCAP_Human2.63890915
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53074426
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46082206
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.41870179
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.41038752
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38286114
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.37979265
25VDR_22108803_ChIP-Seq_LS180_Human2.36299417
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32876707
27FOXP3_21729870_ChIP-Seq_TREG_Human2.22952262
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.22327009
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.21693225
30E2F1_21310950_ChIP-Seq_MCF-7_Human2.20829057
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.18536678
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17823033
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.16422089
34NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05147131
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01859653
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.99424517
37XRN2_22483619_ChIP-Seq_HELA_Human1.93979487
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.85981678
39TTF2_22483619_ChIP-Seq_HELA_Human1.82568205
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.80268245
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.79301803
42DCP1A_22483619_ChIP-Seq_HELA_Human1.77066580
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74149043
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72465683
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.69391273
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.65915092
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.62306347
48GABP_19822575_ChIP-Seq_HepG2_Human1.62100213
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61991720
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59032674
51MYC_18940864_ChIP-ChIP_HL60_Human1.57163947
52SOX2_16153702_ChIP-ChIP_HESCs_Human1.56233221
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55654380
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.44566985
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43610490
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.38464700
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32675944
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29034669
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.23747018
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20694093
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20270353
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17420635
63BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14285205
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13875997
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13416296
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12475275
67IRF1_19129219_ChIP-ChIP_H3396_Human1.11054655
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10612278
69KDM5A_27292631_Chip-Seq_BREAST_Human1.09229313
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08495870
71IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08268980
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07142923
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05631915
74CIITA_25753668_ChIP-Seq_RAJI_Human1.05207864
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02997968
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00519133
77EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96120875
78EWS_26573619_Chip-Seq_HEK293_Human0.95098407
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93822836
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91844743
81ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90560867
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89719179
83ZNF274_21170338_ChIP-Seq_K562_Hela0.89105537
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88398096
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87294219
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84890432
87CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82260653
88SOX17_20123909_ChIP-Seq_XEN_Mouse0.80660085
89ELK1_22589737_ChIP-Seq_MCF10A_Human0.79244255
90PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.76338591
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74159441
92IGF1R_20145208_ChIP-Seq_DFB_Human0.72860476
93NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.72302215
94STAT3_1855785_ChIP-Seq_MESCs_Mouse0.69390870
95ERG_20517297_ChIP-Seq_VCAP_Human0.69242225
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.66622335
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.64717435
98CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.58323026
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.57051936
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.56734958

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.43605927
2MP0010094_abnormal_chromosome_stability5.21842385
3MP0008058_abnormal_DNA_repair4.34977821
4MP0003111_abnormal_nucleus_morphology4.32518754
5MP0004957_abnormal_blastocyst_morpholog4.13492263
6MP0003077_abnormal_cell_cycle3.38299525
7MP0003718_maternal_effect2.98155338
8MP0008007_abnormal_cellular_replicative2.77533404
9MP0009697_abnormal_copulation2.76825996
10MP0008789_abnormal_olfactory_epithelium2.70394370
11MP0008932_abnormal_embryonic_tissue2.69156865
12MP0002938_white_spotting2.65101969
13MP0003806_abnormal_nucleotide_metabolis2.48791740
14MP0003786_premature_aging2.44452565
15MP0008877_abnormal_DNA_methylation2.41841562
16MP0006035_abnormal_mitochondrial_morpho2.31714719
17MP0006292_abnormal_olfactory_placode2.16210226
18MP0001529_abnormal_vocalization2.05724184
19MP0008057_abnormal_DNA_replication2.04327198
20MP0010307_abnormal_tumor_latency1.83406764
21MP0006036_abnormal_mitochondrial_physio1.81557733
22MP0005171_absent_coat_pigmentation1.77568240
23MP0001293_anophthalmia1.76572111
24MP0001661_extended_life_span1.71032224
25MP0003186_abnormal_redox_activity1.69892136
26MP0003941_abnormal_skin_development1.62503180
27MP0009384_cardiac_valve_regurgitation1.54507735
28MP0000049_abnormal_middle_ear1.53746095
29MP0005083_abnormal_biliary_tract1.52304140
30MP0006072_abnormal_retinal_apoptosis1.51639819
31MP0005394_taste/olfaction_phenotype1.46359179
32MP0005499_abnormal_olfactory_system1.46359179
33MP0000313_abnormal_cell_death1.41105535
34MP0005503_abnormal_tendon_morphology1.39280992
35MP0001929_abnormal_gametogenesis1.36989357
36MP0000350_abnormal_cell_proliferation1.36531309
37MP0001485_abnormal_pinna_reflex1.32194723
38MP0004134_abnormal_chest_morphology1.30256620
39MP0001697_abnormal_embryo_size1.28920298
40MP0009379_abnormal_foot_pigmentation1.27179950
41MP0000358_abnormal_cell_content/1.26357602
42MP0003937_abnormal_limbs/digits/tail_de1.24720626
43MP0005075_abnormal_melanosome_morpholog1.23947583
44MP0000516_abnormal_urinary_system1.23434484
45MP0005367_renal/urinary_system_phenotyp1.23434484
46MP0010030_abnormal_orbit_morphology1.22768846
47MP0002210_abnormal_sex_determination1.20015192
48MP0002160_abnormal_reproductive_system1.19456635
49MP0001119_abnormal_female_reproductive1.19115232
50MP0001145_abnormal_male_reproductive1.12599590
51MP0005084_abnormal_gallbladder_morpholo1.10509444
52MP0000653_abnormal_sex_gland1.07140297
53MP0002019_abnormal_tumor_incidence1.03265799
54MP0004147_increased_porphyrin_level1.03234043
55MP0002080_prenatal_lethality1.00450838
56MP0005395_other_phenotype0.94352704
57MP0002085_abnormal_embryonic_tissue0.93337221
58MP0001177_atelectasis0.92318119
59MP0005380_embryogenesis_phenotype0.92126450
60MP0001672_abnormal_embryogenesis/_devel0.92126450
61MP0002111_abnormal_tail_morphology0.91643842
62MP0005253_abnormal_eye_physiology0.88492038
63MP0009053_abnormal_anal_canal0.84391522
64MP0001730_embryonic_growth_arrest0.83497845
65MP0001853_heart_inflammation0.83143820
66MP0004197_abnormal_fetal_growth/weight/0.82828232
67MP0003699_abnormal_female_reproductive0.82822424
68MP0000372_irregular_coat_pigmentation0.80548712
69MP0003011_delayed_dark_adaptation0.78295051
70MP0002396_abnormal_hematopoietic_system0.77477036
71MP0005389_reproductive_system_phenotype0.74895366
72MP0002006_tumorigenesis0.73350407
73MP0002095_abnormal_skin_pigmentation0.73323954
74MP0003984_embryonic_growth_retardation0.72974499
75MP0003119_abnormal_digestive_system0.72317493
76MP0004215_abnormal_myocardial_fiber0.71812209
77MP0003890_abnormal_embryonic-extraembry0.71463348
78MP0001286_abnormal_eye_development0.71333237
79MP0002088_abnormal_embryonic_growth/wei0.69892201
80MP0009672_abnormal_birth_weight0.69239572
81MP0000631_abnormal_neuroendocrine_gland0.67412546
82MP0002161_abnormal_fertility/fecundity0.66092390
83MP0000703_abnormal_thymus_morphology0.65873452
84MP0002089_abnormal_postnatal_growth/wei0.65051210
85MP0005379_endocrine/exocrine_gland_phen0.63549051
86MP0002233_abnormal_nose_morphology0.62828473
87MP0002084_abnormal_developmental_patter0.61427843
88MP0003698_abnormal_male_reproductive0.61336544
89MP0002086_abnormal_extraembryonic_tissu0.60705105
90MP0003936_abnormal_reproductive_system0.60389133
91MP0002796_impaired_skin_barrier0.56704279
92MP0002102_abnormal_ear_morphology0.56452956
93MP0005391_vision/eye_phenotype0.56194937
94MP0008872_abnormal_physiological_respon0.55568150
95MP0005501_abnormal_skin_physiology0.53365568
96MP0002722_abnormal_immune_system0.52359064
97MP0002751_abnormal_autonomic_nervous0.51110188
98MP0009333_abnormal_splenocyte_physiolog0.50850951
99MP0000428_abnormal_craniofacial_morphol0.50522676
100MP0005671_abnormal_response_to0.49095391

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.98599137
2Abnormal mitochondria in muscle tissue (HP:0008316)3.68413120
3Acute encephalopathy (HP:0006846)3.59814080
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.55283421
5Increased CSF lactate (HP:0002490)3.54239783
6Abnormality of the labia minora (HP:0012880)3.52882534
7Mitochondrial inheritance (HP:0001427)3.51270441
8Chromsome breakage (HP:0040012)3.17439450
9Progressive macrocephaly (HP:0004481)3.17267409
10Hepatocellular necrosis (HP:0001404)3.12634039
11Abnormal number of erythroid precursors (HP:0012131)3.10387293
12Increased serum pyruvate (HP:0003542)3.06522061
13Aplastic anemia (HP:0001915)3.02613167
14Medulloblastoma (HP:0002885)3.01589728
15Abnormality of cells of the erythroid lineage (HP:0012130)3.01145778
16Abnormality of the ileum (HP:0001549)2.97722285
17Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.95784037
18Degeneration of the lateral corticospinal tracts (HP:0002314)2.95784037
19Birth length less than 3rd percentile (HP:0003561)2.93536979
20Abnormality of the carotid arteries (HP:0005344)2.92486303
21Abnormality of chromosome stability (HP:0003220)2.89540963
22Abnormality of alanine metabolism (HP:0010916)2.87116448
23Hyperalaninemia (HP:0003348)2.87116448
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.87116448
25Cerebral edema (HP:0002181)2.86352799
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.83379933
27Hepatic necrosis (HP:0002605)2.83115250
28Meckel diverticulum (HP:0002245)2.77533958
29Abnormality of the preputium (HP:0100587)2.70174695
30Absent radius (HP:0003974)2.63633567
31Increased serum lactate (HP:0002151)2.57682295
32Nephroblastoma (Wilms tumor) (HP:0002667)2.57362410
33Short thumb (HP:0009778)2.55964877
34Bilateral microphthalmos (HP:0007633)2.54615342
35Short phalanx of the thumb (HP:0009660)2.52300887
36Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.51222396
37Short 4th metacarpal (HP:0010044)2.51222396
38Abnormality of glycolysis (HP:0004366)2.49199463
39Abnormal lung lobation (HP:0002101)2.48487649
40Absent forearm bone (HP:0003953)2.48263783
41Aplasia involving forearm bones (HP:0009822)2.48263783
42Median cleft lip (HP:0000161)2.45999816
43Abnormal number of incisors (HP:0011064)2.45121974
44Stenosis of the external auditory canal (HP:0000402)2.44468775
45Embryonal renal neoplasm (HP:0011794)2.43577726
46Increased hepatocellular lipid droplets (HP:0006565)2.41886959
47Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41687103
48Volvulus (HP:0002580)2.34542589
49Absent thumb (HP:0009777)2.33437061
50Abnormality of the nasal septum (HP:0000419)2.31440570
51Optic nerve coloboma (HP:0000588)2.30729700
52Small intestinal stenosis (HP:0012848)2.29432467
53Duodenal stenosis (HP:0100867)2.29432467
54Neoplasm of the oral cavity (HP:0100649)2.29134954
55Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.28137846
56Patellar aplasia (HP:0006443)2.25318761
57Oligodactyly (HP:0012165)2.23956166
58Oligodactyly (hands) (HP:0001180)2.23406131
59Spinal muscular atrophy (HP:0007269)2.23131675
60Aplasia/Hypoplasia of the patella (HP:0006498)2.19987905
61Horseshoe kidney (HP:0000085)2.19134574
62Lipid accumulation in hepatocytes (HP:0006561)2.18291486
63Cleft eyelid (HP:0000625)2.15561144
64Congenital, generalized hypertrichosis (HP:0004540)2.14896690
65Oral leukoplakia (HP:0002745)2.14244150
66Triphalangeal thumb (HP:0001199)2.14090337
67Lactic acidosis (HP:0003128)2.13578632
68Myelodysplasia (HP:0002863)2.13493588
69Abnormality of serum amino acid levels (HP:0003112)2.11310623
70Clubbing of toes (HP:0100760)2.09161404
71Abnormality of the duodenum (HP:0002246)2.09021165
72Colon cancer (HP:0003003)2.08391787
73Respiratory failure (HP:0002878)2.05942304
74Depressed nasal tip (HP:0000437)2.04577455
75Leukodystrophy (HP:0002415)2.04431225
76Aplasia/Hypoplasia of the sternum (HP:0006714)1.99260715
77Intestinal atresia (HP:0011100)1.98997961
78Aplasia/Hypoplasia involving the musculature (HP:0001460)1.98947566
793-Methylglutaconic aciduria (HP:0003535)1.97133097
80Multiple enchondromatosis (HP:0005701)1.96916150
81Facial hemangioma (HP:0000329)1.95775051
82Abnormal protein glycosylation (HP:0012346)1.92519692
83Abnormal glycosylation (HP:0012345)1.92519692
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92519692
85Abnormal protein N-linked glycosylation (HP:0012347)1.92519692
86Aplasia/hypoplasia of the humerus (HP:0006507)1.91408499
87B lymphocytopenia (HP:0010976)1.90426063
88Rectal fistula (HP:0100590)1.89805546
89Rectovaginal fistula (HP:0000143)1.89805546
90Carpal bone hypoplasia (HP:0001498)1.89231857
91Pancreatic islet-cell hyperplasia (HP:0004510)1.87748130
92Abnormality of the anterior horn cell (HP:0006802)1.86411328
93Degeneration of anterior horn cells (HP:0002398)1.86411328
94Meningioma (HP:0002858)1.85974039
95Decreased activity of mitochondrial respiratory chain (HP:0008972)1.82700407
96Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.82700407
97Hypoplasia of the pons (HP:0012110)1.82296862
98CNS demyelination (HP:0007305)1.81853346
99Abnormality of B cell number (HP:0010975)1.81550147
100Optic disc pallor (HP:0000543)1.80064927

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.98930706
2TLK14.78978191
3BUB14.43422682
4VRK14.15255978
5CDC73.00375000
6VRK23.00063943
7PBK2.98149586
8MST42.53463691
9EIF2AK12.50138179
10NEK12.46481496
11TSSK62.44555709
12NUAK12.36212141
13BCKDK2.27958945
14MKNK22.25854350
15PLK32.06478336
16CCNB12.03287498
17BRSK21.92618687
18TTK1.85810533
19WEE11.85039898
20PLK41.83287363
21AURKA1.75509333
22BRSK11.72169769
23EIF2AK31.71244306
24SRPK11.71227849
25TAF11.69126694
26PLK11.64801078
27NME21.63561323
28EPHA31.55441584
29AURKB1.49702523
30ADRBK21.40030350
31PDK21.38279991
32ATR1.36078779
33MKNK11.35858042
34STK161.13888044
35RPS6KA51.13777572
36TAOK31.00396328
37NME10.99281801
38PIM20.94899494
39PIK3CA0.91519634
40CHEK20.90711226
41STK40.90469658
42MAP4K20.88325210
43CHEK10.83045426
44EIF2AK20.78974593
45TESK20.76746439
46DAPK30.67792387
47RAF10.67025240
48LATS10.65979295
49ACVR1B0.65973119
50MAP3K80.65152128
51TRIM280.65032421
52PRKCI0.62302498
53CSNK2A10.62104096
54PIM10.61831200
55MAP3K90.60020140
56STK100.59575551
57ATM0.56523447
58NEK60.55778462
59PLK20.55086859
60GRK10.55040972
61CDK90.53310000
62BMPR1B0.53058632
63CLK10.50819707
64CSNK2A20.46232225
65NEK20.44165149
66CDK70.43247180
67TIE10.42561082
68KDR0.41394129
69CDK10.38960756
70WNK30.38140133
71CDK20.37128974
72DYRK20.34693277
73ABL20.34224464
74PKN10.33791882
75MARK30.31939670
76MELK0.31874150
77CSNK1G10.30835180
78RPS6KB10.28247654
79PAK10.25914677
80IKBKB0.25007754
81ERBB30.24035023
82CSNK1G30.23602385
83ALK0.21656050
84CDK40.21282949
85DAPK10.19481896
86PRKDC0.19034804
87CDK180.18154783
88FGFR10.16643145
89CDK150.15983822
90CSNK1G20.14488307
91RPS6KB20.13912927
92CSNK1A1L0.12950500
93ADRBK10.12065824
94GSK3A0.11835542
95RPS6KA40.11726125
96CSNK1E0.11451252
97DYRK30.11442604
98CDK140.10872416
99CSNK1A10.10739240
100PNCK0.10415505

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.85778271
2DNA replication_Homo sapiens_hsa030304.01887960
3Systemic lupus erythematosus_Homo sapiens_hsa053223.57267221
4Ribosome_Homo sapiens_hsa030103.35165575
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.30884635
6Homologous recombination_Homo sapiens_hsa034403.06273522
7Mismatch repair_Homo sapiens_hsa034302.98006741
8Base excision repair_Homo sapiens_hsa034102.79780255
9RNA polymerase_Homo sapiens_hsa030202.75605579
10Oxidative phosphorylation_Homo sapiens_hsa001902.74706213
11Parkinsons disease_Homo sapiens_hsa050122.70535263
12Non-homologous end-joining_Homo sapiens_hsa034502.49942024
13Spliceosome_Homo sapiens_hsa030402.34566851
14Fanconi anemia pathway_Homo sapiens_hsa034602.29610500
15Cell cycle_Homo sapiens_hsa041102.16769334
16Protein export_Homo sapiens_hsa030602.11859331
17Alcoholism_Homo sapiens_hsa050342.09415351
18Huntingtons disease_Homo sapiens_hsa050162.01425740
19RNA degradation_Homo sapiens_hsa030181.95339067
20RNA transport_Homo sapiens_hsa030131.90670370
21Nucleotide excision repair_Homo sapiens_hsa034201.86066226
22Basal transcription factors_Homo sapiens_hsa030221.79055430
23Pyrimidine metabolism_Homo sapiens_hsa002401.65379421
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56489266
25One carbon pool by folate_Homo sapiens_hsa006701.53480034
26Alzheimers disease_Homo sapiens_hsa050101.50338777
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44953014
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32420557
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25566080
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22542321
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22507891
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.18063013
33Pyruvate metabolism_Homo sapiens_hsa006201.17993395
34Propanoate metabolism_Homo sapiens_hsa006401.14183151
35Purine metabolism_Homo sapiens_hsa002301.13964706
36Oocyte meiosis_Homo sapiens_hsa041141.09148122
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04925992
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03935921
39Sulfur relay system_Homo sapiens_hsa041221.02416947
40Folate biosynthesis_Homo sapiens_hsa007901.02261874
41Viral carcinogenesis_Homo sapiens_hsa052030.99374218
42p53 signaling pathway_Homo sapiens_hsa041150.97462922
43mRNA surveillance pathway_Homo sapiens_hsa030150.97263328
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90690573
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86740046
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.78757307
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75389842
48Cardiac muscle contraction_Homo sapiens_hsa042600.72544904
49Peroxisome_Homo sapiens_hsa041460.69180596
50Epstein-Barr virus infection_Homo sapiens_hsa051690.67708797
51Primary immunodeficiency_Homo sapiens_hsa053400.67279260
52Glutathione metabolism_Homo sapiens_hsa004800.66686439
53Basal cell carcinoma_Homo sapiens_hsa052170.59897032
54Asthma_Homo sapiens_hsa053100.56183549
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55825719
56Carbon metabolism_Homo sapiens_hsa012000.54496369
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54455150
58Fatty acid elongation_Homo sapiens_hsa000620.52398365
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52109611
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51927145
61Metabolic pathways_Homo sapiens_hsa011000.50804228
62Biosynthesis of amino acids_Homo sapiens_hsa012300.48029955
63Vitamin B6 metabolism_Homo sapiens_hsa007500.46455497
64Tryptophan metabolism_Homo sapiens_hsa003800.46409126
65N-Glycan biosynthesis_Homo sapiens_hsa005100.46099714
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45025443
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.43070414
68Antigen processing and presentation_Homo sapiens_hsa046120.41955999
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38931926
70Chemical carcinogenesis_Homo sapiens_hsa052040.37947277
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37369295
72HTLV-I infection_Homo sapiens_hsa051660.33766137
73Herpes simplex infection_Homo sapiens_hsa051680.31389333
74Vitamin digestion and absorption_Homo sapiens_hsa049770.30159473
75Mineral absorption_Homo sapiens_hsa049780.29051677
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25821613
77Legionellosis_Homo sapiens_hsa051340.23228559
78Retinol metabolism_Homo sapiens_hsa008300.22673657
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22390153
80Sulfur metabolism_Homo sapiens_hsa009200.21631654
81Histidine metabolism_Homo sapiens_hsa003400.21403764
82Nitrogen metabolism_Homo sapiens_hsa009100.20887459
83Caffeine metabolism_Homo sapiens_hsa002320.19353823
84Selenocompound metabolism_Homo sapiens_hsa004500.19213176
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18076142
86Hippo signaling pathway_Homo sapiens_hsa043900.17120061
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15845290
88Bladder cancer_Homo sapiens_hsa052190.15442689
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.15064593
90Butanoate metabolism_Homo sapiens_hsa006500.14779387
91TGF-beta signaling pathway_Homo sapiens_hsa043500.13918050
92Phototransduction_Homo sapiens_hsa047440.12876051
93Hedgehog signaling pathway_Homo sapiens_hsa043400.12532528
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.10796958
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.09672444
96Allograft rejection_Homo sapiens_hsa053300.08364269
97Wnt signaling pathway_Homo sapiens_hsa043100.07899829
98beta-Alanine metabolism_Homo sapiens_hsa004100.07327094
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.06370722
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.05394311

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