HIST1H2BA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.75396009
2acrosome assembly (GO:0001675)9.71441452
3motile cilium assembly (GO:0044458)9.52968815
4positive regulation of synaptic transmission, dopaminergic (GO:0032226)9.13529733
5cell-cell recognition (GO:0009988)9.08517277
6DNA methylation involved in gamete generation (GO:0043046)9.07326251
7spermatid development (GO:0007286)8.94350471
8positive regulation of catecholamine secretion (GO:0033605)8.61737003
9cell wall macromolecule metabolic process (GO:0044036)8.50483787
10cell wall macromolecule catabolic process (GO:0016998)8.50483787
11epithelial cilium movement (GO:0003351)8.02697942
12multicellular organism reproduction (GO:0032504)7.84284824
13plasma membrane fusion (GO:0045026)7.72400252
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.65444794
15male meiosis I (GO:0007141)7.51957979
16cilium movement (GO:0003341)7.03388348
17chromosome organization involved in meiosis (GO:0070192)7.01291309
18negative regulation of inclusion body assembly (GO:0090084)6.82921520
19regulation of oxidative stress-induced neuron death (GO:1903203)6.62422757
20meiotic nuclear division (GO:0007126)6.57355107
21regulation of cilium movement (GO:0003352)6.55830308
22reproduction (GO:0000003)6.47362491
23meiosis I (GO:0007127)6.14526649
24spermatogenesis (GO:0007283)6.06705909
25male gamete generation (GO:0048232)6.04469370
26relaxation of smooth muscle (GO:0044557)6.03727411
27polyamine biosynthetic process (GO:0006596)5.87039665
28fertilization (GO:0009566)5.60828963
29organic cation transport (GO:0015695)5.58316642
30potassium ion export (GO:0071435)5.58117165
31gamete generation (GO:0007276)5.55418534
32regulation of oxidative phosphorylation (GO:0002082)5.53543817
33single fertilization (GO:0007338)5.51582992
34meiotic cell cycle (GO:0051321)5.49639167
35seminiferous tubule development (GO:0072520)5.48925707
36germ cell development (GO:0007281)5.48101712
37regulation of inclusion body assembly (GO:0090083)5.33462235
38cGMP-mediated signaling (GO:0019934)5.30267263
39Leydig cell differentiation (GO:0033327)5.29637596
40* cellular process involved in reproduction in multicellular organism (GO:0022412)5.21982044
41protein localization to cilium (GO:0061512)5.19060416
42gene silencing by RNA (GO:0031047)5.09251387
43male sex determination (GO:0030238)5.01033443
44phosphatidylethanolamine biosynthetic process (GO:0006646)4.98101294
45genitalia morphogenesis (GO:0035112)4.95840733
46regulation of meiosis I (GO:0060631)4.86809865
47ventricular system development (GO:0021591)4.83011994
48sperm capacitation (GO:0048240)4.77260925
49activation of protein kinase B activity (GO:0032148)4.74614095
50positive regulation of glycolytic process (GO:0045821)4.70489654
51negative regulation of hydrogen peroxide-induced cell death (GO:1903206)4.68804492
52TOR signaling (GO:0031929)4.62304080
53phosphatidylethanolamine metabolic process (GO:0046337)4.55266701
54microtubule severing (GO:0051013)4.54701591
55response to acidic pH (GO:0010447)4.48271611
56DNA packaging (GO:0006323)4.44148419
57cell recognition (GO:0008037)4.35993754
58left/right pattern formation (GO:0060972)4.34987697
59regulation of hydrogen peroxide-induced cell death (GO:1903205)4.30899072
60histone H3-K9 demethylation (GO:0033169)4.30777051
61multicellular organismal reproductive process (GO:0048609)4.30428170
62microtubule depolymerization (GO:0007019)4.29083252
63negative regulation of response to reactive oxygen species (GO:1901032)4.25776620
64meiotic cell cycle process (GO:1903046)4.24174158
65calcium ion-dependent exocytosis (GO:0017156)4.17683070
66chromosome condensation (GO:0030261)4.16387067
67tongue development (GO:0043586)4.07911323
68regulation of dopamine secretion (GO:0014059)4.07707496
69protein polymerization (GO:0051258)4.06521175
70coenzyme catabolic process (GO:0009109)4.05345338
71mitochondrion degradation (GO:0000422)4.00370120
72oogenesis (GO:0048477)3.99785465
73glutamine family amino acid catabolic process (GO:0009065)3.99439045
74synapsis (GO:0007129)3.98871524
75nuclear pore complex assembly (GO:0051292)3.97386214
76intraciliary transport (GO:0042073)3.94799531
77cellular biogenic amine biosynthetic process (GO:0042401)3.94232821
78regulation of microtubule-based movement (GO:0060632)3.91330517
79amine biosynthetic process (GO:0009309)3.86308437
80negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.85851365
81glycogen metabolic process (GO:0005977)3.84106083
82androgen biosynthetic process (GO:0006702)3.83172673
83carnitine transmembrane transport (GO:1902603)3.80723517
84glucan metabolic process (GO:0044042)3.80425126
85cellular glucan metabolic process (GO:0006073)3.80425126
86regulation of phosphatase activity (GO:0010921)3.79778195
87carnitine transport (GO:0015879)3.75750161
88amino-acid betaine transport (GO:0015838)3.75750161
89protein polyglutamylation (GO:0018095)3.73313834
90regulation of autophagic vacuole assembly (GO:2000785)3.66222380
91DNA alkylation (GO:0006305)3.58975959
92DNA methylation (GO:0006306)3.58975959
93translesion synthesis (GO:0019985)3.56730563
94multicellular organismal development (GO:0007275)3.54731207
95regulation of spindle checkpoint (GO:0090231)3.53481681
96gene silencing (GO:0016458)3.50766299
97sequestering of actin monomers (GO:0042989)3.47473441
98regulation of synaptic transmission, dopaminergic (GO:0032225)3.44314956
99regulation of cellular respiration (GO:0043457)3.42639256
100monoubiquitinated protein deubiquitination (GO:0035520)3.40800349
101interferon-gamma secretion (GO:0072643)3.36215988
102DNA double-strand break processing (GO:0000729)3.34316123
103chaperone-mediated protein complex assembly (GO:0051131)3.33107159
104axoneme assembly (GO:0035082)3.32487847
105negative regulation of organelle assembly (GO:1902116)3.26314954
106regulation of protein polyubiquitination (GO:1902914)3.24443146
107polyamine metabolic process (GO:0006595)3.23725263
108detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.21361695
109negative regulation of JNK cascade (GO:0046329)3.20683751
110membrane repolarization during action potential (GO:0086011)3.20327853
111dicarboxylic acid biosynthetic process (GO:0043650)3.18004242
112protein refolding (GO:0042026)3.17460392
113positive regulation of amine transport (GO:0051954)3.16778028
114mitotic sister chromatid cohesion (GO:0007064)3.15061414
115nuclear pore organization (GO:0006999)3.14931200
116diacylglycerol metabolic process (GO:0046339)3.14065805
117cellular response to pH (GO:0071467)3.11705421
118pore complex assembly (GO:0046931)3.11586144
119regulation of chromatin binding (GO:0035561)3.10638204
120RNA localization (GO:0006403)3.06991089
121nucleus organization (GO:0006997)3.05834124
122microtubule-based movement (GO:0007018)3.05021243
123negative regulation of DNA repair (GO:0045738)3.04000562
124regulation of histone H3-K9 methylation (GO:0051570)3.01660348
125aspartate family amino acid catabolic process (GO:0009068)2.98724675
126cellular response to toxic substance (GO:0097237)2.97017361
127regulation of vacuole organization (GO:0044088)2.96903707
128histone H3-K36 demethylation (GO:0070544)2.96169722
129regulation of dephosphorylation (GO:0035303)2.93676121
130negative regulation of smooth muscle contraction (GO:0045986)2.93223225
131peptidyl-glutamic acid modification (GO:0018200)2.91682800
132cilium organization (GO:0044782)2.89968615
133peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.88635604
134spermatid nucleus differentiation (GO:0007289)2.86952157
135RNA destabilization (GO:0050779)2.78435313
136cilium morphogenesis (GO:0060271)2.76342408
137sex differentiation (GO:0007548)2.74541627
138regulation of centriole replication (GO:0046599)2.74314980
139sister chromatid cohesion (GO:0007062)2.73145381
140lactate metabolic process (GO:0006089)2.72713329
141cilium assembly (GO:0042384)2.70033354
142polyol catabolic process (GO:0046174)2.69603812
143DNA methylation or demethylation (GO:0044728)2.67923889
144regulation of acrosome reaction (GO:0060046)2.64724127
145piRNA metabolic process (GO:0034587)13.2607118
146cilium or flagellum-dependent cell motility (GO:0001539)12.8350309
147synaptonemal complex organization (GO:0070193)10.6770918
148male meiosis (GO:0007140)10.6757260
149sperm motility (GO:0030317)10.5483960
150axonemal dynein complex assembly (GO:0070286)10.5195956
151regulation of phosphoprotein phosphatase activity (GO:0043666)10.3301739
152fusion of sperm to egg plasma membrane (GO:0007342)10.1952192
153sperm-egg recognition (GO:0035036)10.1709363
154synaptonemal complex assembly (GO:0007130)10.0422253
155binding of sperm to zona pellucida (GO:0007339)10.0356284

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.42442345
2EZH2_22144423_ChIP-Seq_EOC_Human6.22553371
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.48547652
4IGF1R_20145208_ChIP-Seq_DFB_Human4.22850124
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.52216474
6ESR1_20079471_ChIP-ChIP_T-47D_Human3.32341283
7VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human3.13896224
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.77181787
9* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.56379204
10GATA1_26923725_Chip-Seq_HPCs_Mouse2.54100254
11FUS_26573619_Chip-Seq_HEK293_Human2.47525022
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.40404518
13GBX2_23144817_ChIP-Seq_PC3_Human2.36881107
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.30754165
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.17864619
16ZNF274_21170338_ChIP-Seq_K562_Hela2.17597413
17ELK4_26923725_Chip-Seq_MESODERM_Mouse2.15610451
18AR_21572438_ChIP-Seq_LNCaP_Human2.01270775
19ARNT_22903824_ChIP-Seq_MCF-7_Human2.00064682
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse12.9497115
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse11.3834812
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.97975898
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.89499127
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87434362
25ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.84847847
26AHR_22903824_ChIP-Seq_MCF-7_Human1.82321631
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73719960
28SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.70844924
29ER_23166858_ChIP-Seq_MCF-7_Human1.68928742
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66029808
31FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63804895
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.61746396
33NANOG_20526341_ChIP-Seq_ESCs_Human1.58640852
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54220069
35GATA1_22025678_ChIP-Seq_K562_Human1.51461253
36WDR5_24793694_ChIP-Seq_LNCAP_Human1.49352877
37RAC3_21632823_ChIP-Seq_H3396_Human1.46497484
38OCT1_27270436_Chip-Seq_PROSTATE_Human1.45784463
39SMAD4_21799915_ChIP-Seq_A2780_Human1.43284658
40GATA3_21867929_ChIP-Seq_CD8_Mouse1.42280511
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.42156728
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41668140
43SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40185523
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39875272
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38536665
46PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37288467
47TBL1_22424771_ChIP-Seq_293T_Human1.35592412
48P300_19829295_ChIP-Seq_ESCs_Human1.35088046
49STAT1_17558387_ChIP-Seq_HELA_Human1.34656634
50CTCF_27219007_Chip-Seq_Bcells_Human1.33327591
51ERA_21632823_ChIP-Seq_H3396_Human1.31775758
52TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.31290719
53KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31007817
54SOX2_22085726_ChIP-Seq_NPCs_Mouse1.29523094
55TP53_18474530_ChIP-ChIP_U2OS_Human1.29144011
56FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.28219588
57RUNX2_22187159_ChIP-Seq_PCA_Human1.27067101
58AR_25329375_ChIP-Seq_VCAP_Human1.26293477
59KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.24675246
60CBP_20019798_ChIP-Seq_JUKART_Human1.22843742
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22843742
62SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.22088295
63SMAD4_21741376_ChIP-Seq_EPCs_Human1.21633559
64GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.21452618
65AR_21909140_ChIP-Seq_LNCAP_Human1.18711491
66RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18256564
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17124311
68SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16232052
69SMC4_20622854_ChIP-Seq_HELA_Human1.15578758
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15488558
71KAP1_22055183_ChIP-Seq_ESCs_Mouse1.13346417
72MYC_19829295_ChIP-Seq_ESCs_Human1.13155960
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.12904810
74RUNX1_26923725_Chip-Seq_HPCs_Mouse1.12795931
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12497448
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10450150
77REST_21632747_ChIP-Seq_MESCs_Mouse1.10285043
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.09330583
79P53_21459846_ChIP-Seq_SAOS-2_Human1.08450851
80LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.07621701
81PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07512066
82BCAT_22108803_ChIP-Seq_LS180_Human1.05927386
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.04642279
84STAT3_23295773_ChIP-Seq_U87_Human1.03317198
85VDR_22108803_ChIP-Seq_LS180_Human1.02287602
86SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02116884
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01802356
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01456072
89PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.01378528
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00739466
91CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00691364
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00561717
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00512323
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00512323
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99684900
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99346222
97KDM2B_26808549_Chip-Seq_REH_Human0.99095054
98ERG_20517297_ChIP-Seq_VCAP_Human0.98988407
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97541217
100RXRA_24833708_ChIP-Seq_LIVER_Mouse0.96706854
101RXR_22108803_ChIP-Seq_LS180_Human0.96543453
102YY1_22570637_ChIP-Seq_MALME-3M_Human0.96010692
103MYC_27129775_Chip-Seq_CORNEA_Mouse0.95796217
104FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94862077
105PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94223301
106TET1_21451524_ChIP-Seq_MESCs_Mouse0.92993956
107RARA_24833708_ChIP-Seq_LIVER_Mouse0.92341370
108FLI1_21867929_ChIP-Seq_TH2_Mouse0.91949824
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91750243
110ELF1_20517297_ChIP-Seq_JURKAT_Human0.91647232
111HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91572164
112RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91492426
113GF1_26923725_Chip-Seq_HPCs_Mouse0.91455220
114SOX2_21211035_ChIP-Seq_LN229_Human0.91144540
115ESET_19884257_ChIP-Seq_ESCs_Mouse0.91104348
116* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90842642
117RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90803189
118IRF1_19129219_ChIP-ChIP_H3396_Human0.89961306
119VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89702351
120LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89590132
121NFYB_21822215_ChIP-Seq_K562_Human0.89097246
122PKCTHETA_26484144_Chip-Seq_BREAST_Human0.88791779
123CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87938971
124OCT4_19829295_ChIP-Seq_ESCs_Human0.86698648
125CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.86169705
126EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85997438
127GF1B_26923725_Chip-Seq_HPCs_Mouse0.85658966
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85384514
129MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.85168662
130CJUN_26792858_Chip-Seq_BT549_Human0.84150851
131KLF4_19829295_ChIP-Seq_ESCs_Human0.84041663
132GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83767825
133* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.83664712
134CTCF_20526341_ChIP-Seq_ESCs_Human0.83577486
135SUZ12_27294783_Chip-Seq_NPCs_Mouse0.83560537
136PHF8_20622854_ChIP-Seq_HELA_Human0.83233260
137PHF8_20622853_ChIP-Seq_HELA_Human0.83147786
138NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.82702590
139FLI1_21867929_ChIP-Seq_CD8_Mouse0.82518929
140CRX_20693478_ChIP-Seq_RETINA_Mouse0.81892821
141PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81769963
142P300_27268052_Chip-Seq_Bcells_Human0.81700120
143TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.81697063
144HOXB7_26014856_ChIP-Seq_BT474_Human0.81362888
145CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.81317544
146P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.80960185
147TP63_23658742_ChIP-Seq_EP156T_Human0.80473399
148HNFA_21074721_ChIP-Seq_CACO-2_Human0.80400652
149SPI1_26923725_Chip-Seq_HPCs_Mouse0.80301979
150CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78419303
151CBX2_22325352_ChIP-Seq_293T-Rex_Human0.78332744
152E2F1_17053090_ChIP-ChIP_MCF-7_Human0.78103769
153CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.78064618
154* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.77650549
155PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77563867
156GATA3_21867929_ChIP-Seq_TH1_Mouse0.77140048
157OCT4_18555785_Chip-Seq_ESCs_Mouse0.77129238
158SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77043146
159* NANOG_19829295_ChIP-Seq_ESCs_Human0.76700580
160* SOX2_19829295_ChIP-Seq_ESCs_Human0.76700580
161CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.76242886
162OCT4_21477851_ChIP-Seq_ESCs_Mouse0.75249559
163NANOG_18555785_Chip-Seq_ESCs_Mouse0.75077172
164NFYA_21822215_ChIP-Seq_K562_Human0.74798645
165SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74556567
166SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.74484156
167TCF4_23295773_ChIP-Seq_U87_Human0.74068653
168OCT4_20526341_ChIP-Seq_ESCs_Human0.73975263
169TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.73647474
170ETV1_20927104_ChIP-Seq_GIST48_Human0.73170680
171CDX2_22108803_ChIP-Seq_LS180_Human0.72818663
172RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.72758993
173AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.72635932
174ZFP57_27257070_Chip-Seq_ESCs_Mouse0.72081938
175BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.72054110
176SMAD3_21741376_ChIP-Seq_ESCs_Human0.71950038
177* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.71584894
178ETS1_22383799_ChIP-Seq_G1ME_Mouse0.70970316

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.35226156
2MP0003315_abnormal_perineum_morphology5.81054864
3MP0003698_abnormal_male_reproductive5.67917669
4MP0001929_abnormal_gametogenesis5.46775890
5MP0008004_abnormal_stomach_pH5.45581773
6MP0002210_abnormal_sex_determination4.00829412
7MP0008057_abnormal_DNA_replication3.54224502
8MP0001145_abnormal_male_reproductive3.39179696
9MP0002161_abnormal_fertility/fecundity3.07849721
10MP0005360_urolithiasis2.97736321
11MP0000653_abnormal_sex_gland2.93554198
12MP0008438_abnormal_cutaneous_collagen2.75107968
13MP0003646_muscle_fatigue2.48892964
14MP0002160_abnormal_reproductive_system2.48287796
15MP0002653_abnormal_ependyma_morphology2.46431128
16MP0010386_abnormal_urinary_bladder2.39293767
17MP0005275_abnormal_skin_tensile2.17414705
18MP0010368_abnormal_lymphatic_system2.15412058
19MP0005410_abnormal_fertilization14.4855110
20MP0002132_abnormal_respiratory_system1.92605574
21MP0005058_abnormal_lysosome_morphology1.87439508
22MP0000538_abnormal_urinary_bladder1.82428637
23MP0004272_abnormal_basement_membrane1.74508877
24MP0003136_yellow_coat_color1.70256087
25MP0001664_abnormal_digestion1.66282813
26MP0010094_abnormal_chromosome_stability1.65908337
27MP0003718_maternal_effect1.61485970
28MP0005670_abnormal_white_adipose1.56302238
29MP0004233_abnormal_muscle_weight1.54276448
30MP0005187_abnormal_penis_morphology1.51294828
31MP0009697_abnormal_copulation1.50265905
32MP0008007_abnormal_cellular_replicative1.49742520
33MP0005503_abnormal_tendon_morphology1.48429805
34MP0005499_abnormal_olfactory_system1.48179316
35MP0005394_taste/olfaction_phenotype1.48179316
36MP0005395_other_phenotype1.31391943
37MP0005623_abnormal_meninges_morphology1.26289216
38MP0006072_abnormal_retinal_apoptosis1.21379894
39MP0005389_reproductive_system_phenotype1.19242215
40MP0003786_premature_aging1.16111574
41MP0003632_abnormal_nervous_system1.12313580
42MP0001905_abnormal_dopamine_level1.11502163
43MP0004134_abnormal_chest_morphology1.10782735
44MP0002168_other_aberrant_phenotype1.09760159
45MP0001849_ear_inflammation1.08867040
46MP0005646_abnormal_pituitary_gland1.04202042
47MP0003011_delayed_dark_adaptation1.04037535
48MP0001188_hyperpigmentation1.03961000
49MP0000465_gastrointestinal_hemorrhage1.03218607
50MP0001984_abnormal_olfaction0.99202117
51MP0008058_abnormal_DNA_repair0.96826457
52MP0004808_abnormal_hematopoietic_stem0.96696997
53MP0002127_abnormal_cardiovascular_syste0.90600001
54MP0005248_abnormal_Harderian_gland0.90578912
55MP0010234_abnormal_vibrissa_follicle0.88751654
56MP0001919_abnormal_reproductive_system0.86432160
57MP0004084_abnormal_cardiac_muscle0.86406697
58MP0002249_abnormal_larynx_morphology0.86345578
59MP0000678_abnormal_parathyroid_gland0.86213744
60MP0009046_muscle_twitch0.85648726
61MP0002282_abnormal_trachea_morphology0.84765476
62MP0000470_abnormal_stomach_morphology0.82982842
63MP0005409_darkened_coat_color0.82154601
64MP0005647_abnormal_sex_gland0.81259617
65MP0004085_abnormal_heartbeat0.81046753
66MP0003115_abnormal_respiratory_system0.78048828
67MP0003385_abnormal_body_wall0.76256922
68MP0005595_abnormal_vascular_smooth0.74666355
69MP0002233_abnormal_nose_morphology0.74342286
70MP0001661_extended_life_span0.74188150
71MP0010307_abnormal_tumor_latency0.73491190
72MP0003111_abnormal_nucleus_morphology0.73311357
73MP0009278_abnormal_bone_marrow0.72219458
74MP0000358_abnormal_cell_content/0.72184358
75MP0000343_altered_response_to0.69898347
76MP0005397_hematopoietic_system_phenotyp0.69063637
77MP0001545_abnormal_hematopoietic_system0.69063637
78MP0001501_abnormal_sleep_pattern0.68785120
79MP0000631_abnormal_neuroendocrine_gland0.67974272
80MP0008995_early_reproductive_senescence0.62699399
81MP0003077_abnormal_cell_cycle0.61150787
82MP0006276_abnormal_autonomic_nervous0.60839624
83MP0001730_embryonic_growth_arrest0.57898852
84MP0000427_abnormal_hair_cycle0.57384418
85MP0003699_abnormal_female_reproductive0.56181958
86MP0001270_distended_abdomen0.56059284
87MP0002102_abnormal_ear_morphology0.54807869
88MP0003941_abnormal_skin_development0.53601591
89MP0003935_abnormal_craniofacial_develop0.53028620
90MP0001765_abnormal_ion_homeostasis0.52524394
91MP0004484_altered_response_of0.52521266
92MP0000230_abnormal_systemic_arterial0.50352535
93MP0006036_abnormal_mitochondrial_physio0.49390989
94MP0003938_abnormal_ear_development0.49082225
95MP0000733_abnormal_muscle_development0.48660802
96MP0000049_abnormal_middle_ear0.48136211
97MP0003091_abnormal_cell_migration0.48103088
98MP0000569_abnormal_digit_pigmentation0.47596357
99MP0005666_abnormal_adipose_tissue0.47362119
100MP0003329_amyloid_beta_deposits0.46213931
101MP0005620_abnormal_muscle_contractility0.45987669
102MP0001119_abnormal_female_reproductive0.44932798
103MP0005171_absent_coat_pigmentation0.44272583
104MP0002234_abnormal_pharynx_morphology0.44032963
105MP0001486_abnormal_startle_reflex0.43943140
106MP0003868_abnormal_feces_composition0.43352858
107MP0002115_abnormal_skeleton_extremities0.42943082
108MP0003045_fibrosis0.42133564
109MP0002269_muscular_atrophy0.41503987
110MP0000026_abnormal_inner_ear0.41081504
111MP0004036_abnormal_muscle_relaxation0.40865242
112MP0001756_abnormal_urination0.40334803
113MP0000313_abnormal_cell_death0.40173309
114MP0003878_abnormal_ear_physiology0.40100203
115MP0005377_hearing/vestibular/ear_phenot0.40100203
116MP0002084_abnormal_developmental_patter0.39543809
117MP0001485_abnormal_pinna_reflex0.39308830
118MP0004811_abnormal_neuron_physiology0.38869754
119MP0006035_abnormal_mitochondrial_morpho0.38675944
120MP0000462_abnormal_digestive_system0.38256974
121MP0003861_abnormal_nervous_system0.37133283
122MP0005174_abnormal_tail_pigmentation0.37038172
123MP0001293_anophthalmia0.36747844
124MP0001963_abnormal_hearing_physiology0.36176103
125MP0003950_abnormal_plasma_membrane0.34928442
126MP0005423_abnormal_somatic_nervous0.34540923
127MP0002928_abnormal_bile_duct0.34216544
128MP0000647_abnormal_sebaceous_gland0.33642930
129MP0008961_abnormal_basal_metabolism0.32833008
130MP0003936_abnormal_reproductive_system0.32760661
131MP0002152_abnormal_brain_morphology0.32699075
132MP0005266_abnormal_metabolism0.32648859
133MP0002971_abnormal_brown_adipose0.31300959
134MP0000015_abnormal_ear_pigmentation0.30937246
135MP0003787_abnormal_imprinting0.30023399
136MP0001727_abnormal_embryo_implantation0.29177663
137MP0001697_abnormal_embryo_size0.29106407
138MP0001672_abnormal_embryogenesis/_devel0.28255729
139MP0005380_embryogenesis_phenotype0.28255729
140MP0005391_vision/eye_phenotype0.27934330
141MP0000751_myopathy0.27918957
142MP0000749_muscle_degeneration0.26905646
143MP0001324_abnormal_eye_pigmentation0.26768952
144MP0005253_abnormal_eye_physiology0.26264485
145MP0001986_abnormal_taste_sensitivity0.26023890
146MP0000604_amyloidosis0.25170429
147MP0002139_abnormal_hepatobiliary_system0.25043893
148MP0009115_abnormal_fat_cell0.24970823
149MP0005551_abnormal_eye_electrophysiolog0.23703026
150MP0002092_abnormal_eye_morphology0.23581080
151MP0000537_abnormal_urethra_morphology0.23454048
152MP0003631_nervous_system_phenotype0.22904284
153MP0000534_abnormal_ureter_morphology0.22875147
154MP0002970_abnormal_white_adipose0.21884656
155MP0003879_abnormal_hair_cell0.21503323
156MP0002085_abnormal_embryonic_tissue0.21409573
157MP0002108_abnormal_muscle_morphology0.20907116
158MP0002080_prenatal_lethality0.20899109
159MP0003633_abnormal_nervous_system0.20638299
160MP0005365_abnormal_bile_salt0.20587381
161MP0003634_abnormal_glial_cell0.20527613
162MP0002169_no_abnormal_phenotype0.19302448
163MP0002873_normal_phenotype0.19079883
164MP0002697_abnormal_eye_size0.19007603
165MP0003984_embryonic_growth_retardation0.17515416
166MP0003959_abnormal_lean_body0.17487264

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.52264257
2Rhinitis (HP:0012384)7.73730851
3Abnormal respiratory motile cilium morphology (HP:0005938)7.63482424
4Abnormal respiratory epithelium morphology (HP:0012253)7.63482424
5Chronic bronchitis (HP:0004469)7.36475493
6Abnormal sex determination (HP:0012244)7.25964130
7Sex reversal (HP:0012245)7.25964130
8Resting tremor (HP:0002322)7.19225816
9Nasal polyposis (HP:0100582)6.32750443
10Hypoplasia of the uterus (HP:0000013)6.19010556
11Infertility (HP:0000789)6.11577131
12Abnormal ciliary motility (HP:0012262)5.88913906
13Abnormality of the lower motor neuron (HP:0002366)5.87987199
14Gonadal dysgenesis (HP:0000133)5.21088295
15Abnormality of the nasal mucosa (HP:0000433)5.18289643
16Nephronophthisis (HP:0000090)4.91435191
17Abnormality of the columella (HP:0009929)4.62697761
18Aplasia/hypoplasia of the uterus (HP:0008684)4.56595540
19Germ cell neoplasia (HP:0100728)4.55337493
20Colitis (HP:0002583)4.54228624
21Amyotrophic lateral sclerosis (HP:0007354)4.49224461
22Bronchiectasis (HP:0002110)4.41913235
23Postural instability (HP:0002172)4.38778989
24Bronchitis (HP:0012387)4.25403482
25Gonadotropin excess (HP:0000837)4.17755250
26Reduced antithrombin III activity (HP:0001976)4.14371232
27Male pseudohermaphroditism (HP:0000037)4.00937383
28Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.88580082
29Fibular hypoplasia (HP:0003038)3.83192823
30Facial hemangioma (HP:0000329)3.82384729
31Abnormality of the renal medulla (HP:0100957)3.65655468
32Upper motor neuron abnormality (HP:0002127)3.52975826
33Impaired proprioception (HP:0010831)3.45582577
34Ventricular fibrillation (HP:0001663)3.42207606
35Degeneration of anterior horn cells (HP:0002398)3.30902308
36Abnormality of the anterior horn cell (HP:0006802)3.30902308
37Thoracolumbar scoliosis (HP:0002944)3.27637189
3811 pairs of ribs (HP:0000878)3.19667531
39Aortic dissection (HP:0002647)3.18328141
40Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.11747956
41Recurrent otitis media (HP:0000403)3.10186147
42Abnormality of the frontal sinuses (HP:0002687)3.06839854
43Abnormal spermatogenesis (HP:0008669)3.06423354
44Urinary urgency (HP:0000012)3.03313535
45Tubular atrophy (HP:0000092)2.97904180
46Self-mutilation (HP:0000742)2.92520221
47Tubulointerstitial nephritis (HP:0001970)2.89541669
48Thoracic kyphosis (HP:0002942)2.85822387
49Selective tooth agenesis (HP:0001592)2.85483867
50Azoospermia (HP:0000027)2.85228968
51Type II lissencephaly (HP:0007260)2.85025953
52Capillary hemangiomas (HP:0005306)2.77656743
53Abnormality of the intrinsic pathway (HP:0010989)2.77327813
54Inflammation of the large intestine (HP:0002037)2.75075177
55Abnormality of midbrain morphology (HP:0002418)2.71781786
56Molar tooth sign on MRI (HP:0002419)2.71781786
57Tubulointerstitial abnormality (HP:0001969)2.71601998
58Occipital encephalocele (HP:0002085)2.61185109
59Retinal atrophy (HP:0001105)2.60515409
60Hypoplasia of the capital femoral epiphysis (HP:0003090)2.59627820
61Aortic aneurysm (HP:0004942)2.56214651
62Male infertility (HP:0003251)2.55365589
63Medial flaring of the eyebrow (HP:0010747)2.53673179
64Sensory axonal neuropathy (HP:0003390)2.52455472
65Atonic seizures (HP:0010819)2.49942825
66Large eyes (HP:0001090)2.48720621
67Protruding tongue (HP:0010808)2.47793988
68Gastrointestinal inflammation (HP:0004386)2.47618556
69Impulsivity (HP:0100710)2.43503167
70Conjunctival telangiectasia (HP:0000524)2.42661210
71Aplasia/Hypoplasia of the fibula (HP:0006492)2.41056258
72Anterior segment dysgenesis (HP:0007700)2.38686450
73Tubulointerstitial fibrosis (HP:0005576)2.35808317
74Retinal dysplasia (HP:0007973)2.33978916
75Atrophic scars (HP:0001075)2.33637245
76Postaxial foot polydactyly (HP:0001830)2.33499515
77Short 4th metacarpal (HP:0010044)2.33393600
78Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.33393600
79Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.32210440
80Chronic hepatic failure (HP:0100626)2.31715270
81Cerebral aneurysm (HP:0004944)2.27866315
82Stage 5 chronic kidney disease (HP:0003774)2.25271098
83Abnormality of the lumbar spine (HP:0100712)2.20044992
84Recurrent sinusitis (HP:0011108)2.19947043
85Recurrent bronchitis (HP:0002837)2.18022142
86Buphthalmos (HP:0000557)2.17977902
87Oculomotor apraxia (HP:0000657)2.16561312
88Renal dysplasia (HP:0000110)2.14829863
89Short nail (HP:0001799)2.12718025
90Congenital sensorineural hearing impairment (HP:0008527)2.12528961
91Polydipsia (HP:0001959)2.10909692
92Abnormal drinking behavior (HP:0030082)2.10909692
93Short ribs (HP:0000773)2.06312367
94Congenital hepatic fibrosis (HP:0002612)2.06134611
95Spinal rigidity (HP:0003306)2.05258659
96Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.03267603
97Absent epiphyses (HP:0010577)2.03267603
98Abnormality of male internal genitalia (HP:0000022)2.02126722
99Osteolytic defects of the hand bones (HP:0009699)2.00771498
100Osteolytic defects of the phalanges of the hand (HP:0009771)2.00771498
101Abnormality of the thoracic spine (HP:0100711)2.00567986
102Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.7330319
103Dynein arm defect of respiratory motile cilia (HP:0012255)10.4493784
104Absent/shortened dynein arms (HP:0200106)10.4493784
105Mitral stenosis (HP:0001718)1.98799075
106Facial cleft (HP:0002006)1.98451787
107Gastrointestinal infarctions (HP:0005244)1.93784413
108Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93019602
109Abnormality of the vasculature of the conjunctiva (HP:0008054)1.91505469
110Abnormality of the renal cortex (HP:0011035)1.90839006
111Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.90046568
112Atrophy/Degeneration involving motor neurons (HP:0007373)1.85549069
113Median cleft lip (HP:0000161)1.84218570
114Decreased motor nerve conduction velocity (HP:0003431)1.83647238
115Short thorax (HP:0010306)1.83061333
116Abnormality of dentin (HP:0010299)1.81586768
117Chronic sinusitis (HP:0011109)1.81324718
118Supernumerary spleens (HP:0009799)1.80574455
119Abnormality of the ileum (HP:0001549)1.79065642
120Bony spicule pigmentary retinopathy (HP:0007737)1.78575514
121Missing ribs (HP:0000921)1.78381338
122Bell-shaped thorax (HP:0001591)1.77041443
123Breast carcinoma (HP:0003002)1.76156882
124Heterotopia (HP:0002282)1.75550319
125Abnormality of ocular smooth pursuit (HP:0000617)1.75355752
126Aplasia/Hypoplasia of the uvula (HP:0010293)1.74744287
127Clubbing of toes (HP:0100760)1.74654716
128Postaxial hand polydactyly (HP:0001162)1.73895828
129Long eyelashes (HP:0000527)1.72563747
130Aplasia/Hypoplasia of the earlobes (HP:0009906)1.72542129
131Absent thumb (HP:0009777)1.72166527
132Unsteady gait (HP:0002317)1.71365837
133High anterior hairline (HP:0009890)1.70389444
134Enlarged kidneys (HP:0000105)1.70223801
135Abnormality of macular pigmentation (HP:0008002)1.69870795
136Vitreoretinal degeneration (HP:0000655)1.69784036
137Inability to walk (HP:0002540)1.69527129
138Gaze-evoked nystagmus (HP:0000640)1.67334969
139Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.66666249
140Coxa valga (HP:0002673)1.65076416
141Cholecystitis (HP:0001082)1.64498524
142Abnormal gallbladder physiology (HP:0012438)1.64498524
143Abnormality of the 4th metacarpal (HP:0010012)1.64133690
144Spinal cord lesions (HP:0100561)1.63571970
145Syringomyelia (HP:0003396)1.63571970
146Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.63138395
147Optic nerve hypoplasia (HP:0000609)1.62726636
148Spastic tetraparesis (HP:0001285)1.62650549
149Broad distal phalanx of finger (HP:0009836)1.62477122
150Syncope (HP:0001279)1.61774275
151Abnormal rod and cone electroretinograms (HP:0008323)1.61519787
152Prolonged QT interval (HP:0001657)1.61385085
153Hypothermia (HP:0002045)1.59435086
154Absent speech (HP:0001344)1.57708505
155Renovascular hypertension (HP:0100817)1.55402886
156Flattened epiphyses (HP:0003071)1.55248240
157Pachygyria (HP:0001302)1.55190557
158Impaired vibratory sensation (HP:0002495)1.53837454
159Meckel diverticulum (HP:0002245)1.53754016
160Abnormal finger flexion creases (HP:0006143)1.53049354
161Absent frontal sinuses (HP:0002688)1.52949554
162Attenuation of retinal blood vessels (HP:0007843)1.52436155
163Absent rod-and cone-mediated responses on ERG (HP:0007688)1.52249228
164Arteriovenous malformation (HP:0100026)1.51314958
165Difficulty walking (HP:0002355)1.50752519
166Nephropathy (HP:0000112)1.48809105
167Choroideremia (HP:0001139)1.47263289
168Abnormality of renal excretion (HP:0011036)1.47115537
169Abnormality of permanent molar morphology (HP:0011071)1.46868989
170Abnormality of the dental root (HP:0006486)1.46868989
171Taurodontia (HP:0000679)1.46868989
172Short femoral neck (HP:0100864)1.46384349
173Abnormality of the epiphyses of the hand (HP:0005924)1.45750714
174Cerebellar dysplasia (HP:0007033)1.44265140
175Hypoplasia of dental enamel (HP:0006297)1.39970372
176Ridged nail (HP:0001807)1.37684442
177Difficulty climbing stairs (HP:0003551)1.37428081
178Abnormality of molar (HP:0011077)1.36715896
179Abnormality of molar morphology (HP:0011070)1.36715896
180Clonus (HP:0002169)1.36339643
181Dyschromatopsia (HP:0007641)1.35546822
182Aplasia/Hypoplasia of the lens (HP:0008063)1.32780214

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.39397775
2PDK48.39397775
3TESK16.42769232
4MARK35.65030717
5PDK25.39670039
6PRKD34.88347076
7ZAK4.87113722
8ICK3.68642061
9MYLK3.09418669
10RPS6KA53.00124877
11PTK2B2.51481453
12NEK22.50382013
13STK382.00891343
14STK391.82445580
15WNK41.78191370
16PNCK1.44135909
17MST1R1.25525986
18PASK1.20652276
19MAP2K71.18953223
20FRK1.18946388
21CDC71.18654664
22STK31.15959748
23LATS21.15451358
24VRK11.10051335
25CDK31.07576507
26SGK4941.06947824
27SGK2231.06947824
28DYRK1B0.94865983
29PDK10.94147563
30FGFR20.91655640
31CSNK1A1L0.87130722
32TYRO30.87023163
33CCNB10.81665361
34WNK10.80284577
35MAP3K90.80048650
36MAPK150.78933349
37TIE10.76620382
38PINK10.73221863
39TTK0.71151870
40MAP3K10.70054877
41DYRK30.69410987
42ATR0.69287444
43ARAF0.66333525
44CSNK1G10.64701779
45MELK0.63643404
46PKN10.61181843
47CSNK1G30.59705604
48TESK20.58224309
49EEF2K0.58164109
50CDK140.57956400
51RET0.55533220
52CHEK20.55294522
53ROCK10.54580512
54MAP3K130.54437382
55OBSCN0.54221475
56AKT30.53133323
57CDC42BPA0.51804679
58DDR20.49806262
59PDGFRA0.48385141
60WEE10.47499044
61MET0.46989701
62PDPK10.45770922
63EIF2AK30.45770247
64BRD40.43129687
65CHEK10.43079707
66CSNK1G20.42417480
67IRAK10.42188872
68TGFBR10.41848091
69KSR20.41462686
70PRKG20.41245052
71FGR0.39849578
72NTRK20.38843310
73SGK20.38649248
74CAMKK10.38242337
75MUSK0.37250766
76MTOR0.35441795
77ATM0.34165565
78PRKAA10.32342613
79CAMK10.32157057
80CDK50.31173683
81MAP3K50.30012335
82WNK30.29659156
83STK38L0.27248808
84NLK0.26721115
85PLK10.26018000
86DAPK30.25594260
87RPS6KB10.24771628
88AKT20.24692578
89STK40.24661901
90LMTK20.22687272
91NEK60.22670085
92TTN0.22542777
93PAK10.22534721
94PAK20.22464698
95MAPK10.22224982
96RIPK40.22205424
97MARK20.21643484
98MAP3K20.21179081
99DYRK20.20788423
100MOS0.20255621
101BMPR1B0.20072442
102BUB10.20054351
103IRAK20.19622085
104MAP4K20.19056709
105CDK80.17856277
106RPS6KA20.17722563
107TAOK10.17715678
108TRIB30.17326401
109PAK60.17125965
110TLK10.16701366
111PRKCG0.16563204
112CAMK1G0.16038203
113CSNK1A10.14941448
114ILK0.13361663
115CSF1R0.13050594
116MAP3K40.11779576
117SGK30.11644789
118MINK10.11116051
119CDK120.10236909
120MAPKAPK50.08873447
121PAK40.08492239
122PLK40.07816204
123PDGFRB0.06747078
124RPS6KA10.06389334
125SRPK10.05190975
126CDK20.04879352
127CDK90.04679537
128CDK10.04347393
129MAPK80.02987057
130MAPK100.02910295
131CSNK1D0.02448631
132BRAF0.02254659
133EGFR0.01836635
134GSK3B0.01433215
135YES10.01325166
136AURKB0.01236567
137PRKCZ0.01077018
138PRKCQ0.00805281
139STK110.00796708
140RPS6KA30.00478884
141CLK10.00435268
142MAP3K100.00400648
143LATS10.00302053
144PRKACG0.00290815
145CSNK2A10.00118643
146PRKCA-0.0633588
147CAMK2A-0.0628473
148ABL1-0.0605062
149CDK4-0.0569944
150PIM1-0.0442233
151PRKD2-0.0436170
152PRKG1-0.0205670
153PRKCB-0.0198493
154STK10-0.0181138
155AURKA-0.0127179
156PRKDC-0.0104751
157PRKACB-0.0079275
158PTK6-0.0051953
159ZAP70-0.0004397

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051307.32291781
2Gap junction_Homo sapiens_hsa045405.29749244
3Vitamin B6 metabolism_Homo sapiens_hsa007504.84238298
4Pyruvate metabolism_Homo sapiens_hsa006204.14793677
5Selenocompound metabolism_Homo sapiens_hsa004503.41144533
6Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.35707997
7Fatty acid biosynthesis_Homo sapiens_hsa000613.07534126
8Dorso-ventral axis formation_Homo sapiens_hsa043203.01275004
9Fanconi anemia pathway_Homo sapiens_hsa034602.96495676
10Propanoate metabolism_Homo sapiens_hsa006402.94627850
11Nitrogen metabolism_Homo sapiens_hsa009102.94179561
12Apoptosis_Homo sapiens_hsa042102.82909166
13Glucagon signaling pathway_Homo sapiens_hsa049222.82556240
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.69071404
15Olfactory transduction_Homo sapiens_hsa047402.64585132
16Pentose phosphate pathway_Homo sapiens_hsa000302.64536804
17Linoleic acid metabolism_Homo sapiens_hsa005912.55089879
18Phagosome_Homo sapiens_hsa041452.54395192
19Basal transcription factors_Homo sapiens_hsa030222.52538661
20Arginine biosynthesis_Homo sapiens_hsa002202.46334645
21Oocyte meiosis_Homo sapiens_hsa041142.20686373
22Glycerolipid metabolism_Homo sapiens_hsa005612.12518258
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92514442
24Amphetamine addiction_Homo sapiens_hsa050311.90141753
25* Systemic lupus erythematosus_Homo sapiens_hsa053221.80227166
26Butanoate metabolism_Homo sapiens_hsa006501.77783774
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.67009286
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.64772231
29PPAR signaling pathway_Homo sapiens_hsa033201.59026667
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.55523594
31Carbohydrate digestion and absorption_Homo sapiens_hsa049731.55375629
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.51627293
33Fat digestion and absorption_Homo sapiens_hsa049751.42818549
34Huntingtons disease_Homo sapiens_hsa050161.41760249
35RNA transport_Homo sapiens_hsa030131.41058103
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.32288479
37Carbon metabolism_Homo sapiens_hsa012001.32259417
38Renin secretion_Homo sapiens_hsa049241.31812287
39Antigen processing and presentation_Homo sapiens_hsa046121.25653432
40Long-term potentiation_Homo sapiens_hsa047201.18667602
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16529989
42Ether lipid metabolism_Homo sapiens_hsa005651.15121404
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.14503711
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14502330
45* Alcoholism_Homo sapiens_hsa050341.12986183
46Protein digestion and absorption_Homo sapiens_hsa049741.11331909
47ABC transporters_Homo sapiens_hsa020101.10167346
48mRNA surveillance pathway_Homo sapiens_hsa030151.08999043
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08765909
50Fatty acid metabolism_Homo sapiens_hsa012121.07058751
51ECM-receptor interaction_Homo sapiens_hsa045121.05145516
52Homologous recombination_Homo sapiens_hsa034401.01010535
53Fructose and mannose metabolism_Homo sapiens_hsa000511.00749203
54Cardiac muscle contraction_Homo sapiens_hsa042601.00678527
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00389863
56Fatty acid degradation_Homo sapiens_hsa000710.98050890
57Glutathione metabolism_Homo sapiens_hsa004800.95276024
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94349751
59Estrogen signaling pathway_Homo sapiens_hsa049150.91928612
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.90460154
61Taste transduction_Homo sapiens_hsa047420.90266507
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79792120
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79520182
64TGF-beta signaling pathway_Homo sapiens_hsa043500.77260519
65Biosynthesis of amino acids_Homo sapiens_hsa012300.74562850
66Oxytocin signaling pathway_Homo sapiens_hsa049210.73393153
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73256990
68VEGF signaling pathway_Homo sapiens_hsa043700.70710124
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70160466
70Phenylalanine metabolism_Homo sapiens_hsa003600.67821328
71Circadian rhythm_Homo sapiens_hsa047100.65512742
72Focal adhesion_Homo sapiens_hsa045100.65406490
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63729640
74AMPK signaling pathway_Homo sapiens_hsa041520.61398436
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.60377170
76Sphingolipid metabolism_Homo sapiens_hsa006000.59844435
77Endometrial cancer_Homo sapiens_hsa052130.59569066
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58052847
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57802843
80Purine metabolism_Homo sapiens_hsa002300.57377503
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56757215
82Choline metabolism in cancer_Homo sapiens_hsa052310.55032019
83Legionellosis_Homo sapiens_hsa051340.53578656
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53466913
85Gastric acid secretion_Homo sapiens_hsa049710.53241420
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52561963
87Cell cycle_Homo sapiens_hsa041100.51247462
88Prostate cancer_Homo sapiens_hsa052150.50839015
89Endocytosis_Homo sapiens_hsa041440.45442880
90N-Glycan biosynthesis_Homo sapiens_hsa005100.45234268
91Chemical carcinogenesis_Homo sapiens_hsa052040.45214572
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44277089
93mTOR signaling pathway_Homo sapiens_hsa041500.44249847
94Arachidonic acid metabolism_Homo sapiens_hsa005900.42608018
95Hedgehog signaling pathway_Homo sapiens_hsa043400.41397778
96Calcium signaling pathway_Homo sapiens_hsa040200.40765745
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.40385543
98* Viral carcinogenesis_Homo sapiens_hsa052030.39573034
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37357729
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37341371
101Inositol phosphate metabolism_Homo sapiens_hsa005620.36825804
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35728988
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.34182633
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34015662
105Tryptophan metabolism_Homo sapiens_hsa003800.33083970
106B cell receptor signaling pathway_Homo sapiens_hsa046620.32213784
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30998343
108MAPK signaling pathway_Homo sapiens_hsa040100.30669910
109Melanoma_Homo sapiens_hsa052180.30598796
110Circadian entrainment_Homo sapiens_hsa047130.30459388
111Tight junction_Homo sapiens_hsa045300.29831054
112RNA degradation_Homo sapiens_hsa030180.29786204
113Salmonella infection_Homo sapiens_hsa051320.29631704
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28876881
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28286584
116Mineral absorption_Homo sapiens_hsa049780.28133775
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28014021
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25839836
119p53 signaling pathway_Homo sapiens_hsa041150.25531252
120Platelet activation_Homo sapiens_hsa046110.24914176
121Tyrosine metabolism_Homo sapiens_hsa003500.24356124
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24017609
123FoxO signaling pathway_Homo sapiens_hsa040680.23560482
124Insulin secretion_Homo sapiens_hsa049110.23464625
125Thyroid hormone synthesis_Homo sapiens_hsa049180.23395162
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22743873
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21924077
128Bile secretion_Homo sapiens_hsa049760.21346764
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.20992791
130Wnt signaling pathway_Homo sapiens_hsa043100.20710691
131Metabolic pathways_Homo sapiens_hsa011000.20440002
132Cocaine addiction_Homo sapiens_hsa050300.20064105
133Type II diabetes mellitus_Homo sapiens_hsa049300.19877096
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.18913031
135HTLV-I infection_Homo sapiens_hsa051660.18676501
136Dilated cardiomyopathy_Homo sapiens_hsa054140.18420953
137Insulin resistance_Homo sapiens_hsa049310.18303345
138HIF-1 signaling pathway_Homo sapiens_hsa040660.17859948
139Glutamatergic synapse_Homo sapiens_hsa047240.17138506
140Salivary secretion_Homo sapiens_hsa049700.16259234
141beta-Alanine metabolism_Homo sapiens_hsa004100.16077580
142cAMP signaling pathway_Homo sapiens_hsa040240.15986059
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15890363
144Retinol metabolism_Homo sapiens_hsa008300.15598923
145Basal cell carcinoma_Homo sapiens_hsa052170.15296387
146Synaptic vesicle cycle_Homo sapiens_hsa047210.15296315
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14988850
148DNA replication_Homo sapiens_hsa030300.14517904
149Renin-angiotensin system_Homo sapiens_hsa046140.14452515
150T cell receptor signaling pathway_Homo sapiens_hsa046600.14243540

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