HIST1H2BB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome organization (GO:0034723)8.26916779
2DNA replication-dependent nucleosome assembly (GO:0006335)8.26916779
3chromatin assembly (GO:0031497)7.89020350
4* nucleosome assembly (GO:0006334)7.30848730
5antibacterial humoral response (GO:0019731)7.25565234
6regulation of histone H3-K9 methylation (GO:0051570)6.89833271
7innate immune response in mucosa (GO:0002227)6.88324233
8antimicrobial humoral response (GO:0019730)6.79540907
9protoporphyrinogen IX metabolic process (GO:0046501)6.52565347
10mitotic chromosome condensation (GO:0007076)6.50370242
11* nucleosome organization (GO:0034728)6.34431110
12* protein-DNA complex assembly (GO:0065004)6.11257014
13sister chromatid segregation (GO:0000819)5.81982386
14protoporphyrinogen IX biosynthetic process (GO:0006782)5.78022742
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.75346907
16chromatin assembly or disassembly (GO:0006333)5.74599378
17DNA unwinding involved in DNA replication (GO:0006268)5.66255458
18nuclear pore complex assembly (GO:0051292)5.65912903
19protein localization to kinetochore (GO:0034501)5.51493095
20* protein-DNA complex subunit organization (GO:0071824)5.49620225
21nuclear pore organization (GO:0006999)5.48194658
22negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)5.46088229
23mucosal immune response (GO:0002385)5.33558037
24mitotic sister chromatid segregation (GO:0000070)5.20731914
25organ or tissue specific immune response (GO:0002251)5.04123732
26protein localization to chromosome, centromeric region (GO:0071459)4.91877520
27regulation of DNA endoreduplication (GO:0032875)4.85631327
28regulation of megakaryocyte differentiation (GO:0045652)4.77426789
29positive regulation of mitotic sister chromatid separation (GO:1901970)4.69389607
30positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.69389607
31positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.69389607
32erythrocyte maturation (GO:0043249)4.62111606
33kinetochore organization (GO:0051383)4.49960378
34regulation of centriole replication (GO:0046599)4.32208019
35pore complex assembly (GO:0046931)4.29997222
36meiotic chromosome segregation (GO:0045132)4.28207497
37positive regulation of chromosome segregation (GO:0051984)4.25957889
38chromosome condensation (GO:0030261)4.23731340
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.14489800
40microtubule depolymerization (GO:0007019)4.13676405
41porphyrin-containing compound biosynthetic process (GO:0006779)4.13090862
42defense response to Gram-positive bacterium (GO:0050830)4.01543982
43mitotic sister chromatid cohesion (GO:0007064)3.99232269
44negative regulation of histone methylation (GO:0031061)3.97226264
45CENP-A containing nucleosome assembly (GO:0034080)3.94953250
46chromatin remodeling at centromere (GO:0031055)3.94824645
47DNA geometric change (GO:0032392)3.92109467
48attachment of spindle microtubules to kinetochore (GO:0008608)3.91506502
49DNA duplex unwinding (GO:0032508)3.91046062
50regulation of sister chromatid cohesion (GO:0007063)3.88235669
51DNA replication initiation (GO:0006270)3.87450204
52DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.86920597
53protein K6-linked ubiquitination (GO:0085020)3.86548112
54DNA topological change (GO:0006265)3.79596833
55regulation of centrosome cycle (GO:0046605)3.78068020
56replicative senescence (GO:0090399)3.76895068
57folic acid-containing compound biosynthetic process (GO:0009396)3.75090136
58dosage compensation (GO:0007549)3.73536143
59mature B cell differentiation involved in immune response (GO:0002313)3.73514037
60hemoglobin metabolic process (GO:0020027)3.70407068
61DNA replication-independent nucleosome organization (GO:0034724)3.69192535
62DNA replication-independent nucleosome assembly (GO:0006336)3.69192535
63regulation of gene silencing (GO:0060968)3.68956915
64mitotic nuclear envelope disassembly (GO:0007077)3.67283713
65regulation of centrosome duplication (GO:0010824)3.61386151
66DNA packaging (GO:0006323)3.60455693
67somatic diversification of immune receptors via somatic mutation (GO:0002566)3.58863129
68somatic hypermutation of immunoglobulin genes (GO:0016446)3.58863129
69telomere maintenance (GO:0000723)3.57114447
70telomere organization (GO:0032200)3.55735141
71mitotic recombination (GO:0006312)3.55333511
72tetrapyrrole biosynthetic process (GO:0033014)3.54638091
73heme biosynthetic process (GO:0006783)3.53864195
74DNA strand elongation involved in DNA replication (GO:0006271)3.51920877
75translesion synthesis (GO:0019985)3.50863224
76membrane disassembly (GO:0030397)3.49161035
77nuclear envelope disassembly (GO:0051081)3.49161035
78positive regulation of systemic arterial blood pressure (GO:0003084)3.46519251
79DNA synthesis involved in DNA repair (GO:0000731)3.43118586
80chromosome segregation (GO:0007059)3.42868848
81DNA conformation change (GO:0071103)3.41486204
82regulation of response to osmotic stress (GO:0047484)3.40446649
83histone exchange (GO:0043486)3.39491305
84regulation of RNA export from nucleus (GO:0046831)3.39484838
85protein localization to chromosome (GO:0034502)3.39297667
86DNA damage response, signal transduction resulting in transcription (GO:0042772)3.36988873
87regulation of spindle organization (GO:0090224)3.34974591
88erythrocyte development (GO:0048821)3.34156001
89pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.33945605
90DNA strand elongation (GO:0022616)3.33895979
91postreplication repair (GO:0006301)3.31887467
92regulation of chromosome segregation (GO:0051983)3.30713302
93mitotic metaphase plate congression (GO:0007080)3.30344753
94regulation of mammary gland epithelial cell proliferation (GO:0033599)3.29668634
95metaphase plate congression (GO:0051310)3.29032794
96telomere maintenance via semi-conservative replication (GO:0032201)3.26925028
97positive regulation of histone methylation (GO:0031062)3.26788461
98telomere maintenance via telomere lengthening (GO:0010833)3.26082437
99definitive hemopoiesis (GO:0060216)3.25749679
100establishment of chromosome localization (GO:0051303)3.23571468
101histone lysine demethylation (GO:0070076)3.20592591
102regulation of mitotic spindle organization (GO:0060236)3.19062935
103mature B cell differentiation (GO:0002335)3.18085301
104regulation of hematopoietic progenitor cell differentiation (GO:1901532)3.17996024
105B cell receptor signaling pathway (GO:0050853)3.17987998
106mitotic DNA integrity checkpoint (GO:0044774)3.16949744
107regulation of mitotic metaphase/anaphase transition (GO:0030071)3.16573030
108histone demethylation (GO:0016577)3.14722291
109regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.13023415
110regulation of double-strand break repair via homologous recombination (GO:0010569)3.12362993
111peptidyl-lysine dimethylation (GO:0018027)3.09093852
112regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.07741541
113telomere maintenance via recombination (GO:0000722)3.07323537
114ATP-dependent chromatin remodeling (GO:0043044)3.04400194
115spindle checkpoint (GO:0031577)3.03917150
116porphyrin-containing compound metabolic process (GO:0006778)3.01950068
117resolution of meiotic recombination intermediates (GO:0000712)3.01330083
118DNA replication checkpoint (GO:0000076)2.99365614
119aggressive behavior (GO:0002118)2.98854053
120spindle assembly involved in mitosis (GO:0090307)2.98161120
121cellular hyperosmotic response (GO:0071474)2.98068783
122regulation of mitotic sister chromatid segregation (GO:0033047)2.97759851
123DNA ligation (GO:0006266)2.92101715
124negative regulation of DNA repair (GO:0045738)2.86818806
125replication fork processing (GO:0031297)2.86585927
126V(D)J recombination (GO:0033151)2.86030546
127maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.82035435
128immunoglobulin mediated immune response (GO:0016064)2.80005144
129regulation of double-strand break repair (GO:2000779)2.71863881
130pyrimidine nucleotide catabolic process (GO:0006244)2.70342940
131protein demethylation (GO:0006482)2.70324133
132protein dealkylation (GO:0008214)2.70324133
133hyperosmotic salinity response (GO:0042538)2.68280001
134microtubule severing (GO:0051013)2.67017273
135somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.66616960
136somatic cell DNA recombination (GO:0016444)2.66616960
137negative regulation of defense response to virus (GO:0050687)2.65991512
138hematopoietic stem cell differentiation (GO:0060218)2.56387836
139regulation of sister chromatid segregation (GO:0033045)2.54446585
140regulation of mitotic sister chromatid separation (GO:0010965)2.54446585
141regulation of RIG-I signaling pathway (GO:0039535)2.54384047
142maternal behavior (GO:0042711)2.54288173

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.05938356
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.32773196
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.43338335
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.72332891
5* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.78343166
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.75952316
7* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.39056905
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.34985721
9TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30630400
10* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.25755661
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.23005521
12* SOX2_16153702_ChIP-ChIP_HESCs_Human2.02591773
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse15.9376649
14* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.90663756
15* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.76158630
16* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.74619036
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71762065
18SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.69921481
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.62657553
20IRF1_19129219_ChIP-ChIP_H3396_Human1.61056331
21AR_21909140_ChIP-Seq_LNCAP_Human1.60014714
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57656509
23ESR1_15608294_ChIP-ChIP_MCF-7_Human1.56697037
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54995193
25HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.47948859
26* HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43240842
27* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43226726
28* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42001568
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.41110351
30GATA1_22025678_ChIP-Seq_K562_Human1.35278892
31* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34436263
32* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31316917
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30931064
34* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30687498
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30212451
36KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.30036525
37VDR_23849224_ChIP-Seq_CD4+_Human1.27922018
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18439279
39ELK1_19687146_ChIP-ChIP_HELA_Human1.15624692
40MYC_22102868_ChIP-Seq_BL_Human1.14866644
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13819810
42* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13065713
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07900684
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07583117
45* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04752716
46* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04559537
47NANOG_16153702_ChIP-ChIP_HESCs_Human1.04467034
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04269337
49GATA1_19941826_ChIP-Seq_K562_Human1.04137297
50* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03569274
51* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.00887262
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98861918
53RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94922810
54IRF8_22096565_ChIP-ChIP_GC-B_Human0.92332894
55SALL1_21062744_ChIP-ChIP_HESCs_Human0.92161317
56* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91185104
57* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89703980
58* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.88761604
59TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88264710
60VDR_21846776_ChIP-Seq_THP-1_Human0.87798334
61VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87482700
62THAP11_20581084_ChIP-Seq_MESCs_Mouse0.86580530
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.81859877
64* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81372573
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.80633969
66MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.78632830
67* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.76155411
68GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75652099
69FOXP3_21729870_ChIP-Seq_TREG_Human0.75579214
70* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.74713103
71RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.72705142
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.72696462
73NANOG_18555785_ChIP-Seq_MESCs_Mouse0.72546321
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.72397547
75* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.72017683
76PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71965149
77MYC_18358816_ChIP-ChIP_MESCs_Mouse0.71332098
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.70067000
79* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.69084562
80MYCN_18555785_ChIP-Seq_MESCs_Mouse0.68966101
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.68614239
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.68051068
83* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.65981339
84KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.64669426
85ZFX_18555785_ChIP-Seq_MESCs_Mouse0.63648821
86MYB_26560356_Chip-Seq_TH1_Human0.63644344
87XRN2_22483619_ChIP-Seq_HELA_Human0.63547621
88MAF_26560356_Chip-Seq_TH1_Human0.62746424
89SCL_19346495_ChIP-Seq_HPC-7_Human0.62606792
90UTX_26944678_Chip-Seq_JUKART_Human0.62302918
91KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.62024274
92MYB_26560356_Chip-Seq_TH2_Human0.61601230
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.61380210
94STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.60470851
95GATA1_19941827_ChIP-Seq_MEL_Mouse0.60214648
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.60105784
97CREB1_15753290_ChIP-ChIP_HEK293T_Human0.60045022
98PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.59816801
99NANOG_21062744_ChIP-ChIP_HESCs_Human0.59000759
100KDM5A_27292631_Chip-Seq_BREAST_Human0.58796316
101SALL4_22934838_ChIP-ChIP_CD34+_Human0.58302050
102CIITA_25753668_ChIP-Seq_RAJI_Human0.55600035
103RUNX1_22412390_ChIP-Seq_EML_Mouse0.55414443
104ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.55150232
105PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.54680643
106HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.54645672
107MYC_18940864_ChIP-ChIP_HL60_Human0.54574667
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.53708911
109TCF7_22412390_ChIP-Seq_EML_Mouse0.53394290
110E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.53190855
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.52238619
112GATA3_27048872_Chip-Seq_THYMUS_Human0.52206880
113* SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.49786185
114GATA2_19941826_ChIP-Seq_K562_Human0.44183203
115NOTCH1_21737748_ChIP-Seq_TLL_Human0.43707899
116SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.43379572
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.43314307
118CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.42701060
119MYB_21317192_ChIP-Seq_ERMYB_Mouse0.40543650
120NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.39265733
121ELF1_17652178_ChIP-ChIP_JURKAT_Human0.38564709
122VDR_24763502_ChIP-Seq_THP-1_Human0.37693339
123SOX9_26525672_Chip-Seq_HEART_Mouse0.37430447

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.04562356
2MP0003656_abnormal_erythrocyte_physiolo4.85041340
3MP0009697_abnormal_copulation4.35850616
4MP0003111_abnormal_nucleus_morphology4.24753045
5MP0004147_increased_porphyrin_level4.21400792
6MP0010307_abnormal_tumor_latency4.08723692
7MP0003077_abnormal_cell_cycle3.74366386
8MP0003693_abnormal_embryo_hatching3.45123796
9MP0008057_abnormal_DNA_replication3.18721685
10MP0004957_abnormal_blastocyst_morpholog2.87346705
11MP0010352_gastrointestinal_tract_polyps2.80521538
12MP0002138_abnormal_hepatobiliary_system2.79920857
13MP0003705_abnormal_hypodermis_morpholog2.64145751
14MP0006054_spinal_hemorrhage2.57824167
15MP0005645_abnormal_hypothalamus_physiol2.39542513
16MP0005076_abnormal_cell_differentiation2.35113280
17MP0001835_abnormal_antigen_presentation2.24796156
18MP0008877_abnormal_DNA_methylation2.22291656
19MP0008058_abnormal_DNA_repair2.20749657
20MP0010234_abnormal_vibrissa_follicle2.20575026
21MP0000350_abnormal_cell_proliferation2.15424275
22MP0002396_abnormal_hematopoietic_system2.00542894
23MP0001730_embryonic_growth_arrest1.99979480
24MP0003763_abnormal_thymus_physiology1.99402942
25MP0004808_abnormal_hematopoietic_stem1.96767650
26MP0008007_abnormal_cellular_replicative1.89402041
27MP0008932_abnormal_embryonic_tissue1.81279727
28MP0002877_abnormal_melanocyte_morpholog1.73001396
29MP0003121_genomic_imprinting1.66707713
30MP0002166_altered_tumor_susceptibility1.65620690
31MP0005083_abnormal_biliary_tract1.64440476
32MP0003123_paternal_imprinting1.63171677
33MP0004197_abnormal_fetal_growth/weight/1.60406027
34MP0000490_abnormal_crypts_of1.59949330
35MP0002019_abnormal_tumor_incidence1.56429576
36MP0009764_decreased_sensitivity_to1.52383627
37MP0002009_preneoplasia1.52302978
38MP0002086_abnormal_extraembryonic_tissu1.51846380
39MP0001697_abnormal_embryo_size1.46866152
40MP0005503_abnormal_tendon_morphology1.46828166
41MP0004134_abnormal_chest_morphology1.45568687
42MP0003300_gastrointestinal_ulcer1.44181188
43MP0003787_abnormal_imprinting1.42363995
44MP0002095_abnormal_skin_pigmentation1.41878914
45MP0002398_abnormal_bone_marrow1.40762522
46MP0005380_embryogenesis_phenotype1.40340536
47MP0001672_abnormal_embryogenesis/_devel1.40340536
48MP0002080_prenatal_lethality1.39192864
49MP0000703_abnormal_thymus_morphology1.38072081
50MP0005187_abnormal_penis_morphology1.36939438
51MP0002722_abnormal_immune_system1.31886380
52MP0002084_abnormal_developmental_patter1.31634976
53MP0005171_absent_coat_pigmentation1.31540529
54MP0000313_abnormal_cell_death1.27806067
55MP0000689_abnormal_spleen_morphology1.26405982
56MP0001661_extended_life_span1.25016930
57MP0002006_tumorigenesis1.23971972
58MP0002085_abnormal_embryonic_tissue1.22537797
59MP0003786_premature_aging1.21117320
60MP0003984_embryonic_growth_retardation1.20688629
61MP0008004_abnormal_stomach_pH1.19690120
62MP0002088_abnormal_embryonic_growth/wei1.18920347
63MP0003252_abnormal_bile_duct1.17693057
64MP0005220_abnormal_exocrine_pancreas1.17669976
65MP0003566_abnormal_cell_adhesion1.14120793
66MP0003950_abnormal_plasma_membrane1.14106577
67MP0002160_abnormal_reproductive_system1.13497242
68MP0001545_abnormal_hematopoietic_system1.11099562
69MP0005397_hematopoietic_system_phenotyp1.11099562
70MP0004381_abnormal_hair_follicle1.10570312
71MP0003718_maternal_effect1.08806963
72MP0001243_abnormal_dermal_layer1.06097785
73MP0000372_irregular_coat_pigmentation1.05939415
74MP0005464_abnormal_platelet_physiology1.05045912
75MP0008770_decreased_survivor_rate1.04214919
76MP0006035_abnormal_mitochondrial_morpho1.03646021
77MP0000733_abnormal_muscle_development1.01569993
78MP0002429_abnormal_blood_cell0.98767627
79MP0000569_abnormal_digit_pigmentation0.97574533
80MP0000685_abnormal_immune_system0.97073421
81MP0003303_peritoneal_inflammation0.95574534
82MP0005000_abnormal_immune_tolerance0.95115040
83MP0000013_abnormal_adipose_tissue0.94164068
84MP0005275_abnormal_skin_tensile0.93517372
85MP0001800_abnormal_humoral_immune0.92851178
86MP0009703_decreased_birth_body0.92346359
87MP0003890_abnormal_embryonic-extraembry0.91049374
88MP0010678_abnormal_skin_adnexa0.90577169
89MP0005621_abnormal_cell_physiology0.90108353
90MP0001915_intracranial_hemorrhage0.89542965
91MP0002092_abnormal_eye_morphology0.87335810
92MP0000537_abnormal_urethra_morphology0.85079897
93MP0005384_cellular_phenotype0.84965264
94MP0001293_anophthalmia0.84922451
95MP0003937_abnormal_limbs/digits/tail_de0.84668700
96MP0003567_abnormal_fetal_cardiomyocyte0.83949356
97MP0005075_abnormal_melanosome_morpholog0.83380451
98MP0005501_abnormal_skin_physiology0.82559337
99MP0002822_catalepsy0.80939663
100MP0002723_abnormal_immune_serum0.80732408
101MP0005387_immune_system_phenotype0.79510304
102MP0001790_abnormal_immune_system0.79510304
103MP0002075_abnormal_coat/hair_pigmentati0.79453601
104MP0002928_abnormal_bile_duct0.79381071
105MP0002060_abnormal_skin_morphology0.79376882
106MP0000465_gastrointestinal_hemorrhage0.78837733
107MP0002638_abnormal_pupillary_reflex0.78392172
108MP0000716_abnormal_immune_system0.77201249
109MP0003806_abnormal_nucleotide_metabolis0.76384529
110MP0000371_diluted_coat_color0.75316937
111MP0001216_abnormal_epidermal_layer0.75298703
112MP0010155_abnormal_intestine_physiology0.74991672
113MP0009672_abnormal_birth_weight0.74191451
114MP0002697_abnormal_eye_size0.73080725
115MP0002405_respiratory_system_inflammati0.72805837
116MP0006072_abnormal_retinal_apoptosis0.72459469
117MP0003868_abnormal_feces_composition0.72308729
118MP0001849_ear_inflammation0.71470886
119MP0002452_abnormal_antigen_presenting0.70955663
120MP0005310_abnormal_salivary_gland0.70511678
121MP0004947_skin_inflammation0.68141473
122MP0005023_abnormal_wound_healing0.67995789
123MP0002111_abnormal_tail_morphology0.66354782
124MP0001929_abnormal_gametogenesis0.64321757
125MP0002925_abnormal_cardiovascular_devel0.63886508
126MP0002420_abnormal_adaptive_immunity0.60820269
127MP0009278_abnormal_bone_marrow0.60660401
128MP0008438_abnormal_cutaneous_collagen0.60541403
129MP0003453_abnormal_keratinocyte_physiol0.60539849
130MP0003448_altered_tumor_morphology0.60262466
131MP0009931_abnormal_skin_appearance0.60138962
132MP0005408_hypopigmentation0.59184030
133MP0002210_abnormal_sex_determination0.58935690
134MP0001819_abnormal_immune_cell0.58552665
135MP0001186_pigmentation_phenotype0.57345226
136MP0000358_abnormal_cell_content/0.56627752
137MP0001191_abnormal_skin_condition0.56055044
138MP0001145_abnormal_male_reproductive0.56054811
139MP0000383_abnormal_hair_follicle0.55958859

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)7.38934522
2Hypochromic microcytic anemia (HP:0004840)6.35532547
3Colitis (HP:0002583)5.27319450
4Neoplasm of the heart (HP:0100544)5.00106264
5Abnormality of the heme biosynthetic pathway (HP:0010472)4.85841502
6Oral leukoplakia (HP:0002745)4.64022788
7IgA deficiency (HP:0002720)4.54421282
8Acanthocytosis (HP:0001927)4.50133150
9Abnormality of the 4th metacarpal (HP:0010012)4.13556709
10Chromsome breakage (HP:0040012)3.86126562
11Agammaglobulinemia (HP:0004432)3.83164911
12Cutaneous melanoma (HP:0012056)3.73004671
13Milia (HP:0001056)3.70675211
14Reticulocytosis (HP:0001923)3.58932045
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.58897825
16Volvulus (HP:0002580)3.56254905
17Abnormality of chromosome stability (HP:0003220)3.43846259
18Abnormality of the parietal bone (HP:0002696)3.41738512
19Down-sloping shoulders (HP:0200021)3.36294272
20Panhypogammaglobulinemia (HP:0003139)3.35201515
21Abnormality of reticulocytes (HP:0004312)3.32494590
22Cholelithiasis (HP:0001081)3.24751809
23Short phalanx of the thumb (HP:0009660)3.12040346
24Hypochromic anemia (HP:0001931)3.11857457
25Posterior subcapsular cataract (HP:0007787)3.05443377
26Impulsivity (HP:0100710)3.01564494
27Deformed sella turcica (HP:0002681)2.97869442
28Verrucae (HP:0200043)2.88053174
29Papilloma (HP:0012740)2.88053174
30Reticulocytopenia (HP:0001896)2.85494670
31High pitched voice (HP:0001620)2.84586876
32Inflammation of the large intestine (HP:0002037)2.84464160
33Autoimmune hemolytic anemia (HP:0001890)2.83527845
34Abnormal gallbladder morphology (HP:0012437)2.80517765
35Cortical dysplasia (HP:0002539)2.76607083
36Insomnia (HP:0100785)2.76191685
37Basal cell carcinoma (HP:0002671)2.75144880
38Recurrent viral infections (HP:0004429)2.73108959
39Cafe-au-lait spot (HP:0000957)2.64300642
40Birth length less than 3rd percentile (HP:0003561)2.63424146
41Prominent nose (HP:0000448)2.62165666
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.60717155
43Supernumerary bones of the axial skeleton (HP:0009144)2.59312709
44Hypopigmentation of the fundus (HP:0007894)2.58904239
45Chronic diarrhea (HP:0002028)2.58342337
46Ependymoma (HP:0002888)2.57563804
47Gastrointestinal inflammation (HP:0004386)2.53092189
48Rhabdomyosarcoma (HP:0002859)2.52323370
49Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.51110780
50Short 4th metacarpal (HP:0010044)2.51110780
51Thyroiditis (HP:0100646)2.50022600
52Supernumerary ribs (HP:0005815)2.47755154
53Clubbing of toes (HP:0100760)2.46859006
54Subacute progressive viral hepatitis (HP:0006572)2.46121661
55Sandal gap (HP:0001852)2.45383747
56Abnormality of the distal phalanx of the thumb (HP:0009617)2.43736899
57Thrombocytosis (HP:0001894)2.43020922
58Abnormality of the fingertips (HP:0001211)2.41302147
59Increased nuchal translucency (HP:0010880)2.40782747
60Selective tooth agenesis (HP:0001592)2.40292848
61Squamous cell carcinoma (HP:0002860)2.40065183
62Duodenal stenosis (HP:0100867)2.37048982
63Small intestinal stenosis (HP:0012848)2.37048982
64Orthostatic hypotension (HP:0001278)2.35165751
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.34925270
66Cerebellar dysplasia (HP:0007033)2.33378762
67Medulloblastoma (HP:0002885)2.33366333
68Cutaneous photosensitivity (HP:0000992)2.32779434
69Short thumb (HP:0009778)2.31362676
70Ulnar bowing (HP:0003031)2.31158883
71Agnosia (HP:0010524)2.30283203
72Viral hepatitis (HP:0006562)2.29517450
73Abnormality of the astrocytes (HP:0100707)2.29463498
74Astrocytoma (HP:0009592)2.29463498
75Central scotoma (HP:0000603)2.28573823
76Subcapsular cataract (HP:0000523)2.27035237
77Heterotopia (HP:0002282)2.25363892
78Abnormality of the prostate (HP:0008775)2.24771889
79Cellulitis (HP:0100658)2.23901077
80Meckel diverticulum (HP:0002245)2.23313099
81Abnormality of the preputium (HP:0100587)2.23115566
82Myelodysplasia (HP:0002863)2.22165312
83Freckling (HP:0001480)2.20629950
84Recurrent sinusitis (HP:0011108)2.20543222
85Abnormality of the sella turcica (HP:0002679)2.17378444
86Abnormality of the labia minora (HP:0012880)2.16044678
87Diaphragmatic weakness (HP:0009113)2.14914811
88Rough bone trabeculation (HP:0100670)2.14844197
89Abnormality of the ileum (HP:0001549)2.13539035
90Ridged nail (HP:0001807)2.12776314
91Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.12468007
92Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.09996816
93Papilledema (HP:0001085)2.09895582
94Abnormality of T cell physiology (HP:0011840)2.09680431
95Sloping forehead (HP:0000340)2.09527687
96Entropion (HP:0000621)2.08762221
97Spontaneous abortion (HP:0005268)2.08728512
98Prostate neoplasm (HP:0100787)2.08320755
99Biliary tract neoplasm (HP:0100574)2.07584111
100Hypoplasia of the capital femoral epiphysis (HP:0003090)2.05433884
101Proximal placement of thumb (HP:0009623)2.04378688
102Recurrent bronchitis (HP:0002837)2.04038088
103Bone marrow hypocellularity (HP:0005528)2.03840534
104Deviation of the thumb (HP:0009603)2.03749542
105Abnormality of B cell number (HP:0010975)1.99954049
106B lymphocytopenia (HP:0010976)1.99954049
107Hepatocellular carcinoma (HP:0001402)1.99246223
108Truncal obesity (HP:0001956)1.98809375
109Paralysis (HP:0003470)1.98099238
110Absent frontal sinuses (HP:0002688)1.95572906
111Spinal muscular atrophy (HP:0007269)1.94287237
112Gastrointestinal carcinoma (HP:0002672)1.94244022
113Malignant gastrointestinal tract tumors (HP:0006749)1.94244022
114Microcytic anemia (HP:0001935)1.93486282
115Glioma (HP:0009733)1.93299033
116Abnormality of cells of the erythroid lineage (HP:0012130)1.92225688
117Abnormality of the gallbladder (HP:0005264)1.90631174
118Abnormality of the carotid arteries (HP:0005344)1.90420118
119Poikiloderma (HP:0001029)1.90050914
120Small epiphyses (HP:0010585)1.88399069
121Ectopic kidney (HP:0000086)1.87768404
122Vertebral fusion (HP:0002948)1.87724173
123Abnormality of the duodenum (HP:0002246)1.87099693
124Neoplasm of the oral cavity (HP:0100649)1.87006284
125Spastic diplegia (HP:0001264)1.86869519
126Hemivertebrae (HP:0002937)1.86459725
127Abnormality of chromosome segregation (HP:0002916)1.86458829
128Abnormality of transition element cation homeostasis (HP:0011030)1.85922289
129Abnormality of the renal collecting system (HP:0004742)1.85379329
130Chronic hepatic failure (HP:0100626)1.84438801
131Chronic otitis media (HP:0000389)1.84197979
132Abnormal hand bone ossification (HP:0010660)1.83524960
133Colon cancer (HP:0003003)1.83050822
134Abnormal ossification of hand bones (HP:0005921)1.81522592
135Patellar aplasia (HP:0006443)1.81447309
136Chronic mucocutaneous candidiasis (HP:0002728)1.80717120
137Recurrent cutaneous fungal infections (HP:0011370)1.80717120
138Cutis marmorata (HP:0000965)1.80519391
13911 pairs of ribs (HP:0000878)1.80434634
140Neoplasm of striated muscle (HP:0009728)1.80413703
141Spontaneous hematomas (HP:0007420)1.80237597
142Broad ribs (HP:0000885)1.79705104
143T lymphocytopenia (HP:0005403)1.78591446
144Erythema (HP:0010783)1.77997878
145Abnormal number of erythroid precursors (HP:0012131)1.77997148
146Abnormality of pyrimidine metabolism (HP:0004353)1.76787362
147Amaurosis fugax (HP:0100576)1.76385829
148Abnormal auditory evoked potentials (HP:0006958)1.76329965
149Acute myeloid leukemia (HP:0004808)1.75418276
150Conjunctival telangiectasia (HP:0000524)1.74557661
151Ankyloglossia (HP:0010296)1.73736448
152Hypoplasia of the pons (HP:0012110)1.72597255
153Abnormality of DNA repair (HP:0003254)1.72455804
154Abnormal trabecular bone morphology (HP:0100671)1.72129316
155Global brain atrophy (HP:0002283)1.71996604
156Long eyelashes (HP:0000527)1.71823268
157Deep philtrum (HP:0002002)1.71534115
158Poor eye contact (HP:0000817)1.71221641
159IgM deficiency (HP:0002850)1.70394632
160Combined immunodeficiency (HP:0005387)1.69857204
161Hypoplasia of the thymus (HP:0000778)1.68903924
162Lymphoma (HP:0002665)1.68866297
163Premature graying of hair (HP:0002216)1.68528015
164Abnormality of iron homeostasis (HP:0011031)1.66996962
165Arteriovenous malformation (HP:0100026)1.66957395
166Carpal bone hypoplasia (HP:0001498)1.66116736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.75158287
2ZAK6.53955883
3VRK13.54616809
4CDC73.49860613
5RPS6KA53.01458474
6MAP3K102.37111669
7CDK122.33398928
8NEK22.20700625
9CDK91.97961185
10SCYL21.85847069
11PIM11.81622373
12EEF2K1.72236897
13WEE11.61105595
14GRK61.58075926
15* AURKB1.53487690
16* STK41.53110151
17PKN21.45853571
18CHEK21.45811459
19EIF2AK11.45123906
20DYRK31.32740580
21SRPK11.22762515
22PKN11.20246671
23TTK1.19722272
24NEK11.12352530
25STK101.09380912
26RPS6KB21.08921460
27DYRK1B1.06432600
28BUB11.05708849
29CAMK1D1.04431185
30MAP2K71.03285804
31PLK11.03111945
32ATR1.02129565
33CDK40.96755035
34MST40.96243425
35TTN0.96009085
36MAP3K40.94106896
37AURKA0.93014349
38CDK80.91809079
39DAPK30.88802533
40CDK60.87277203
41BMPR1B0.86109647
42BCKDK0.82937920
43PLK30.81874527
44BTK0.81056025
45CHEK10.79192570
46BLK0.78819006
47FRK0.77308482
48STK30.75674705
49PASK0.73362833
50MELK0.71387485
51TAOK30.70515799
52ATM0.70512814
53BRD40.69659055
54PIK3CG0.69634147
55TEC0.63290433
56CDK20.59766080
57FLT30.59618104
58MAP2K30.59063955
59ACVR1B0.56882153
60* MAP3K80.55771581
61AKT20.53295730
62MARK30.52701171
63TRPM70.51942371
64BRSK20.51285731
65CDK10.50186276
66LRRK20.49622108
67CSNK1D0.47319747
68BRSK10.46857221
69EIF2AK30.45109728
70FGFR20.44713313
71MAP2K40.44404748
72KDR0.43232674
73BMX0.40704661
74TAF10.40589388
75TRIB30.39819059
76NME20.38339228
77CDK70.37637948
78FGR0.36398449
79* PRKAA10.36280239
80PBK0.35502497
81MST1R0.33593870
82EIF2AK20.33216003
83SGK10.33127038
84TBK10.32738622
85PRKCQ0.32721423
86IKBKE0.32113478
87JAK20.31729193
88CAMK40.31610052
89NUAK10.31563602
90RPS6KA40.31445463
91NEK90.31003574
92CAMK1G0.30756780
93MET0.30042140
94PRKDC0.29681897
95EPHA20.29466091
96MAP3K10.28839988
97CSF1R0.27744855
98CAMKK20.26661790
99MAP3K140.26441287
100MAPK140.26097881
101MTOR0.25402162
102PRPF4B0.24280272
103PRKCI0.23767841
104IKBKB0.23058643
105TGFBR10.22865778
106PLK40.22601383
107KIT0.21695868
108EPHA30.21477738
109RET0.21376915
110MAP4K10.21182509
111SYK0.20294161
112ROCK10.20257739
113MAPK110.19853144
114KSR10.19625334
115PAK10.19592493
116PRKCD0.19439867
117SMG10.18893289
118SGK30.18587390
119MAP3K130.18187869
120CCNB10.18080033
121ALK0.17645422
122LYN0.17077797
123MAPKAPK30.16876954
124RPS6KB10.15395216
125FGFR30.15267191
126CSNK2A20.15189934
127CLK10.14680961
128LATS10.14468975
129SGK20.12837076
130BRAF0.12245338
131RPS6KC10.12216821
132RPS6KL10.12216821
133PTK60.11782750
134* RPS6KA30.11052592
135TSSK60.10956338
136MAPK90.10756620
137NLK0.10141916
138MAPK10.09969794
139PRKCB0.09836854

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.71880762
2* Viral carcinogenesis_Homo sapiens_hsa052033.43882584
3DNA replication_Homo sapiens_hsa030302.56332872
4Mismatch repair_Homo sapiens_hsa034302.17140404
5Cell cycle_Homo sapiens_hsa041102.02394253
6* Systemic lupus erythematosus_Homo sapiens_hsa0532211.8027725
7Transcriptional misregulation in cancer_Homo sapiens_hsa052021.77093766
8Non-homologous end-joining_Homo sapiens_hsa034501.75917981
9Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.70184688
10One carbon pool by folate_Homo sapiens_hsa006701.58719383
11Fanconi anemia pathway_Homo sapiens_hsa034601.53049166
12Base excision repair_Homo sapiens_hsa034101.40303099
13Nucleotide excision repair_Homo sapiens_hsa034201.34112953
14Homologous recombination_Homo sapiens_hsa034401.32984805
15RNA transport_Homo sapiens_hsa030131.26645797
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22174343
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16303804
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12824480
19p53 signaling pathway_Homo sapiens_hsa041151.04860769
20Spliceosome_Homo sapiens_hsa030401.02863597
21Allograft rejection_Homo sapiens_hsa053301.00560319
22Asthma_Homo sapiens_hsa053100.90991468
23MicroRNAs in cancer_Homo sapiens_hsa052060.86571928
24mRNA surveillance pathway_Homo sapiens_hsa030150.84226973
25Small cell lung cancer_Homo sapiens_hsa052220.81483952
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79423683
27Autoimmune thyroid disease_Homo sapiens_hsa053200.79182971
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77860296
29Graft-versus-host disease_Homo sapiens_hsa053320.73741771
30Non-small cell lung cancer_Homo sapiens_hsa052230.72943291
31Oocyte meiosis_Homo sapiens_hsa041140.70721369
32Ribosome_Homo sapiens_hsa030100.69591774
33Chronic myeloid leukemia_Homo sapiens_hsa052200.69095153
34Type I diabetes mellitus_Homo sapiens_hsa049400.68283208
35Antigen processing and presentation_Homo sapiens_hsa046120.64923708
36B cell receptor signaling pathway_Homo sapiens_hsa046620.60800661
37Selenocompound metabolism_Homo sapiens_hsa004500.60728890
38HTLV-I infection_Homo sapiens_hsa051660.59685095
39Herpes simplex infection_Homo sapiens_hsa051680.56945567
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56540660
41Epstein-Barr virus infection_Homo sapiens_hsa051690.52020056
42Pyrimidine metabolism_Homo sapiens_hsa002400.50496553
43Apoptosis_Homo sapiens_hsa042100.49867254
44Hematopoietic cell lineage_Homo sapiens_hsa046400.49405710
45Malaria_Homo sapiens_hsa051440.48351365
46RNA degradation_Homo sapiens_hsa030180.47998026
47Pancreatic cancer_Homo sapiens_hsa052120.47899786
48mTOR signaling pathway_Homo sapiens_hsa041500.46361100
49Hepatitis B_Homo sapiens_hsa051610.46178583
50Glioma_Homo sapiens_hsa052140.45940356
51Bladder cancer_Homo sapiens_hsa052190.44209605
52Prostate cancer_Homo sapiens_hsa052150.41111762
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.40151606
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39966154
55FoxO signaling pathway_Homo sapiens_hsa040680.37063575
56Measles_Homo sapiens_hsa051620.35881503
57Lysine degradation_Homo sapiens_hsa003100.35856164
58Fatty acid elongation_Homo sapiens_hsa000620.35543589
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34381084
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.34168877
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34112629
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34032654
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33341130
64Dorso-ventral axis formation_Homo sapiens_hsa043200.33321297
65Colorectal cancer_Homo sapiens_hsa052100.32510514
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30342059
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29760243
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28912152
69Primary immunodeficiency_Homo sapiens_hsa053400.28034515
70Melanoma_Homo sapiens_hsa052180.25349348
71Proteoglycans in cancer_Homo sapiens_hsa052050.24132218
72Pentose phosphate pathway_Homo sapiens_hsa000300.23433818
73Endometrial cancer_Homo sapiens_hsa052130.21646848
74Staphylococcus aureus infection_Homo sapiens_hsa051500.21316823
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20196126
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.20121617
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19535610
78Influenza A_Homo sapiens_hsa051640.19435111
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.19200067
80RNA polymerase_Homo sapiens_hsa030200.19160708
81Platelet activation_Homo sapiens_hsa046110.18976563
82AMPK signaling pathway_Homo sapiens_hsa041520.18853055
83TGF-beta signaling pathway_Homo sapiens_hsa043500.18377168
84Sulfur relay system_Homo sapiens_hsa041220.18158007
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.17956254
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17930100
87Thyroid cancer_Homo sapiens_hsa052160.17874747
88Inositol phosphate metabolism_Homo sapiens_hsa005620.17799055
89Legionellosis_Homo sapiens_hsa051340.17202149
90HIF-1 signaling pathway_Homo sapiens_hsa040660.17048161
91Osteoclast differentiation_Homo sapiens_hsa043800.15905447
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15791098
93Acute myeloid leukemia_Homo sapiens_hsa052210.15476367
94Basal transcription factors_Homo sapiens_hsa030220.14699889
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14362128
96Renin-angiotensin system_Homo sapiens_hsa046140.14091695
97Hedgehog signaling pathway_Homo sapiens_hsa043400.13290668
98Biosynthesis of amino acids_Homo sapiens_hsa012300.13248199
99Adherens junction_Homo sapiens_hsa045200.12955815
100Pathways in cancer_Homo sapiens_hsa052000.12885274
101Focal adhesion_Homo sapiens_hsa045100.12688356
102Toxoplasmosis_Homo sapiens_hsa051450.12641537
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.11821095
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.11614649
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.11512633
106Vitamin B6 metabolism_Homo sapiens_hsa007500.11016883
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.10922077
108Viral myocarditis_Homo sapiens_hsa054160.10124900
109Leishmaniasis_Homo sapiens_hsa051400.10122351
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.09792176
111ABC transporters_Homo sapiens_hsa020100.09058027
112Purine metabolism_Homo sapiens_hsa002300.08665075
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.08293594
114Glutathione metabolism_Homo sapiens_hsa004800.08054500
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.07565797
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07326715
117Basal cell carcinoma_Homo sapiens_hsa052170.07235405
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.06904711
119Notch signaling pathway_Homo sapiens_hsa043300.06034397
120Prolactin signaling pathway_Homo sapiens_hsa049170.05147456
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.04838514
122Shigellosis_Homo sapiens_hsa051310.04122162
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.03924871
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.03645543
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.03642680
126Sulfur metabolism_Homo sapiens_hsa009200.03625681
127Tuberculosis_Homo sapiens_hsa051520.03460012
128T cell receptor signaling pathway_Homo sapiens_hsa046600.02249456
129Regulation of autophagy_Homo sapiens_hsa041400.01653299

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