HIST1H2BC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. The protein has antibacterial and antifungal antimicrobial activity. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome assembly (GO:0006335)8.83754021
2DNA replication-dependent nucleosome organization (GO:0034723)8.83754021
3* nucleosome assembly (GO:0006334)8.01633666
4chromatin assembly (GO:0031497)7.61717966
5* antimicrobial humoral response (GO:0019730)7.54336232
6nuclear pore complex assembly (GO:0051292)7.02399522
7* protein-DNA complex assembly (GO:0065004)6.78159919
8* nucleosome organization (GO:0034728)6.66794566
9regulation of histone H3-K9 methylation (GO:0051570)6.42048505
10axon ensheathment in central nervous system (GO:0032291)6.41371910
11central nervous system myelination (GO:0022010)6.41371910
12nuclear pore organization (GO:0006999)6.24270364
13* protein-DNA complex subunit organization (GO:0071824)5.81468313
14fatty acid elongation (GO:0030497)5.73594280
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.65056457
16L-phenylalanine catabolic process (GO:0006559)5.65056457
17pore complex assembly (GO:0046931)5.52105012
18chromatin assembly or disassembly (GO:0006333)5.48040337
19negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)5.26857550
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.19070682
21L-phenylalanine metabolic process (GO:0006558)5.19070682
22cholesterol biosynthetic process (GO:0006695)4.68242350
23DNA unwinding involved in DNA replication (GO:0006268)4.61495629
24DNA strand elongation involved in DNA replication (GO:0006271)4.43913908
25DNA strand elongation (GO:0022616)4.27468047
26protein localization to chromosome, centromeric region (GO:0071459)4.17200989
27DNA replication initiation (GO:0006270)4.15628154
28nucleotide transmembrane transport (GO:1901679)4.10658823
29cysteine metabolic process (GO:0006534)4.08782233
30sterol biosynthetic process (GO:0016126)4.06821595
31aromatic amino acid family catabolic process (GO:0009074)4.04484599
32creatine metabolic process (GO:0006600)4.01100667
33mitotic chromosome condensation (GO:0007076)4.00422835
34very long-chain fatty acid metabolic process (GO:0000038)3.93581102
35telomere maintenance via semi-conservative replication (GO:0032201)3.84044047
36response to methylmercury (GO:0051597)3.83778807
37CENP-A containing nucleosome assembly (GO:0034080)3.82914325
38signal peptide processing (GO:0006465)3.82089765
39amyloid precursor protein catabolic process (GO:0042987)3.81647869
40mitotic sister chromatid segregation (GO:0000070)3.76781527
41regulation of megakaryocyte differentiation (GO:0045652)3.73769017
42ensheathment of neurons (GO:0007272)3.72004568
43axon ensheathment (GO:0008366)3.72004568
44myelin maintenance (GO:0043217)3.70106680
45sister chromatid segregation (GO:0000819)3.69599066
46myelination (GO:0042552)3.68748321
47aldehyde catabolic process (GO:0046185)3.66688215
48V(D)J recombination (GO:0033151)3.63460440
49viral mRNA export from host cell nucleus (GO:0046784)3.62353633
50heme transport (GO:0015886)3.59879226
51chromatin remodeling at centromere (GO:0031055)3.59114288
52long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.58690786
53* defense response to Gram-positive bacterium (GO:0050830)3.58128172
54negative regulation of thymocyte apoptotic process (GO:0070244)3.57030737
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.55077116
56amyloid precursor protein metabolic process (GO:0042982)3.54200994
57telomere maintenance via recombination (GO:0000722)3.50901838
58B cell receptor signaling pathway (GO:0050853)3.48328671
59glyoxylate metabolic process (GO:0046487)3.47699206
60pyrimidine-containing compound transmembrane transport (GO:0072531)3.46233681
61fatty-acyl-CoA biosynthetic process (GO:0046949)3.46037656
62isoprenoid biosynthetic process (GO:0008299)3.45930183
63protoporphyrinogen IX metabolic process (GO:0046501)3.44656689
64bile acid biosynthetic process (GO:0006699)3.41567530
65mature B cell differentiation involved in immune response (GO:0002313)3.36599431
66positive regulation of cellular amine metabolic process (GO:0033240)3.34144583
67mitotic recombination (GO:0006312)3.32130800
68adhesion of symbiont to host cell (GO:0044650)3.30594643
69virion attachment to host cell (GO:0019062)3.30594643
70DNA duplex unwinding (GO:0032508)3.30246650
71alpha-linolenic acid metabolic process (GO:0036109)3.29013418
72regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.27980010
73tyrosine metabolic process (GO:0006570)3.27419827
74glutathione derivative biosynthetic process (GO:1901687)3.26827561
75glutathione derivative metabolic process (GO:1901685)3.26827561
76response to lead ion (GO:0010288)3.25578597
77regulation of sister chromatid cohesion (GO:0007063)3.24476062
78fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.23358549
79response to nitrosative stress (GO:0051409)3.20833593
80fatty-acyl-CoA metabolic process (GO:0035337)3.19553015
81mitotic nuclear envelope disassembly (GO:0007077)3.19480296
82protoporphyrinogen IX biosynthetic process (GO:0006782)3.18676868
83DNA synthesis involved in DNA repair (GO:0000731)3.18053665
84DNA geometric change (GO:0032392)3.17709354
85cellular glucuronidation (GO:0052695)3.14043231
86regulation of cholesterol metabolic process (GO:0090181)3.13846944
87sulfur amino acid catabolic process (GO:0000098)3.12818969
88regulation of lipoprotein metabolic process (GO:0050746)3.12605850
89cofactor catabolic process (GO:0051187)3.11320509
90uronic acid metabolic process (GO:0006063)3.11208332
91glucuronate metabolic process (GO:0019585)3.11208332
92embryonic process involved in female pregnancy (GO:0060136)3.08258173
93short-chain fatty acid metabolic process (GO:0046459)3.07415994
94very-low-density lipoprotein particle assembly (GO:0034379)3.06723853
95peptidyl-lysine dimethylation (GO:0018027)3.03054349
96response to redox state (GO:0051775)3.01622948
97acyl-CoA biosynthetic process (GO:0071616)2.98257334
98thioester biosynthetic process (GO:0035384)2.98257334
99double-strand break repair via nonhomologous end joining (GO:0006303)2.97987255
100non-recombinational repair (GO:0000726)2.97987255
101long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.97559918
102negative regulation of DNA repair (GO:0045738)2.95472318
103aromatic amino acid family metabolic process (GO:0009072)2.94288873
104regulation of centrosome cycle (GO:0046605)2.93828038
105mitotic sister chromatid cohesion (GO:0007064)2.93714358
106regulation of cholesterol biosynthetic process (GO:0045540)2.93531340
107membrane disassembly (GO:0030397)2.93026953
108nuclear envelope disassembly (GO:0051081)2.93026953
109* mucosal immune response (GO:0002385)2.92919291
110heme metabolic process (GO:0042168)2.91544558
111import into cell (GO:0098657)2.91450283
112cholesterol metabolic process (GO:0008203)2.89004566
113positive regulation of mitotic sister chromatid separation (GO:1901970)2.88356928
114positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.88356928
115positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.88356928
116GPI anchor biosynthetic process (GO:0006506)2.87638539
117telomere maintenance (GO:0000723)2.87462628
118glutathione biosynthetic process (GO:0006750)2.87374655
119positive regulation of chromosome segregation (GO:0051984)2.87010594
120cellular ketone body metabolic process (GO:0046950)2.85667827
121telomere organization (GO:0032200)2.85400523
122triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.84630042
123positive regulation of lipoprotein lipase activity (GO:0051006)2.84193572
124positive regulation of triglyceride lipase activity (GO:0061365)2.84193572
125replicative senescence (GO:0090399)2.84145606
126* organ or tissue specific immune response (GO:0002251)2.83719475
127nucleotide transport (GO:0006862)2.83667233
128thioester metabolic process (GO:0035383)2.83211869
129acyl-CoA metabolic process (GO:0006637)2.83211869
130* antibacterial humoral response (GO:0019731)2.82929448
131drug transmembrane transport (GO:0006855)2.82912725
132mature B cell differentiation (GO:0002335)2.82865276
133glutathione metabolic process (GO:0006749)2.81880391
134oligodendrocyte differentiation (GO:0048709)2.80923634
135nonribosomal peptide biosynthetic process (GO:0019184)2.80276216
136proline biosynthetic process (GO:0006561)2.79998524
137plasma lipoprotein particle clearance (GO:0034381)2.79427001
138protein localization to kinetochore (GO:0034501)2.78980124
139B cell proliferation (GO:0042100)2.78381544
140regulation of chromosome segregation (GO:0051983)2.76762863
141positive regulation of histone methylation (GO:0031062)2.76529649
142B cell mediated immunity (GO:0019724)2.76189000
143response to lipoprotein particle (GO:0055094)2.75682258
144adhesion of symbiont to host (GO:0044406)2.75616639
145immunoglobulin mediated immune response (GO:0016064)2.75608533
146bile acid metabolic process (GO:0008206)2.75478456
147acetyl-CoA metabolic process (GO:0006084)2.75192594
148regulation of translational fidelity (GO:0006450)2.74660799
149heme biosynthetic process (GO:0006783)2.74538882
150ketone body metabolic process (GO:1902224)2.74331957
151positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.74294761
152fatty acid beta-oxidation (GO:0006635)2.73962885
153DNA replication-independent nucleosome assembly (GO:0006336)2.73481992
154DNA replication-independent nucleosome organization (GO:0034724)2.73481992
155regulation of cholesterol esterification (GO:0010872)2.73419628
156opsonization (GO:0008228)2.73138885
157hemoglobin metabolic process (GO:0020027)2.72696953
158fatty acid catabolic process (GO:0009062)2.71738458
159positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.71566157
160regulation of centriole replication (GO:0046599)2.71503554
161nucleotide-excision repair, DNA gap filling (GO:0006297)2.70840080
162histone exchange (GO:0043486)2.69551832
163coenzyme catabolic process (GO:0009109)2.69551281
164somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.69547413
165somatic cell DNA recombination (GO:0016444)2.69547413
166steroid biosynthetic process (GO:0006694)2.69234912
167regulation of gene silencing (GO:0060968)2.67838534
168fatty acid oxidation (GO:0019395)2.67433682
169sterol metabolic process (GO:0016125)2.66350879
170glycerophospholipid catabolic process (GO:0046475)2.66153250
171regulation of B cell receptor signaling pathway (GO:0050855)2.65920354
172GPI anchor metabolic process (GO:0006505)2.65846432
173protein carboxylation (GO:0018214)2.65749155
174peptidyl-glutamic acid carboxylation (GO:0017187)2.65749155
175mitochondrial DNA metabolic process (GO:0032042)2.65700258
176lipid oxidation (GO:0034440)2.65089050
177photoreceptor cell differentiation (GO:0046530)2.64604124
178DNA conformation change (GO:0071103)2.63912311
179regulation of centrosome duplication (GO:0010824)2.62118926
180positive regulation of alpha-beta T cell proliferation (GO:0046641)2.56939972
181T cell lineage commitment (GO:0002360)2.56856317
182telomere maintenance via telomere lengthening (GO:0010833)2.56638434
183meiotic chromosome segregation (GO:0045132)2.56127232
184negative regulation of B cell apoptotic process (GO:0002903)2.54881457
185definitive hemopoiesis (GO:0060216)2.54752386
186kinetochore organization (GO:0051383)2.51216846
187T-helper 1 type immune response (GO:0042088)2.50934909
188histone phosphorylation (GO:0016572)2.49688062
189maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.48936437
190negative regulation of chromosome segregation (GO:0051985)2.48564198
191ATP-dependent chromatin remodeling (GO:0043044)2.48419700
192regulation of mitotic sister chromatid separation (GO:0010965)2.47785516
193regulation of mitotic sister chromatid segregation (GO:0033047)2.47785516
194regulation of sister chromatid segregation (GO:0033045)2.47785516
195regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.47668284
196regulation of mitotic metaphase/anaphase transition (GO:0030071)2.47668284
197* innate immune response in mucosa (GO:0002227)10.5984556

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.13977272
2EGR1_23403033_ChIP-Seq_LIVER_Mouse5.47582374
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.02105680
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.43397258
5* RXR_22158963_ChIP-Seq_LIVER_Mouse3.47605360
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.13344688
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.12276426
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.89933663
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.83130230
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.51856781
11* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34860549
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.30635682
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24637640
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.09853894
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.09505116
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse14.5161083
17* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.97445605
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.92833139
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.90451420
20GATA1_22025678_ChIP-Seq_K562_Human1.81072657
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.80643000
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.76736342
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74482839
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.73606933
25GATA1_19941826_ChIP-Seq_K562_Human1.63962239
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63930689
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54492683
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50268643
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.48693395
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43820712
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.41333942
32ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39581358
33SOX2_16153702_ChIP-ChIP_HESCs_Human1.34504005
34* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34235354
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29892045
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27809560
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.26424349
38VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26200724
39VDR_23849224_ChIP-Seq_CD4+_Human1.25109844
40AR_21909140_ChIP-Seq_LNCAP_Human1.24835757
41HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24042672
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22144590
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22144590
44HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21833003
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21637829
46* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16382167
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16273545
48* ETS1_22383799_ChIP-Seq_G1ME_Mouse1.16064940
49MYC_22102868_ChIP-Seq_BL_Human1.14957635
50* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13487243
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13366784
52* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13297198
53* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12064537
54NANOG_16153702_ChIP-ChIP_HESCs_Human1.10325235
55TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10254058
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09876265
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09254678
58SOX2_20726797_ChIP-Seq_SW620_Human1.08871065
59ELK1_19687146_ChIP-ChIP_HELA_Human1.08383694
60* CLOCK_20551151_ChIP-Seq_293T_Human1.08172394
61VDR_21846776_ChIP-Seq_THP-1_Human1.06783556
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.05709774
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03889247
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02303239
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02136877
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01970937
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01310903
68FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99521803
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99379701
70* IRF1_19129219_ChIP-ChIP_H3396_Human0.98752573
71IRF8_22096565_ChIP-ChIP_GC-B_Human0.98383400
72GATA4_25053715_ChIP-Seq_YYC3_Human0.96395103
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94032186
74ESR1_21235772_ChIP-Seq_MCF-7_Human0.93672759
75FOXA1_25552417_ChIP-Seq_VCAP_Human0.93349867
76SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92940017
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92621824
78MAF_26560356_Chip-Seq_TH1_Human0.91992020
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91911879
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91154403
81* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91059047
82KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.90531594
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90232294
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90097535
85* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89923368
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87349475
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87262758
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85748011
89GATA2_19941826_ChIP-Seq_K562_Human0.84940450
90HTT_18923047_ChIP-ChIP_STHdh_Human0.84524826
91POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84391544
92* CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.84385090
93RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83991340
94MYC_18358816_ChIP-ChIP_MESCs_Mouse0.83426018
95* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.83371038
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.81464029
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.81452071
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.80782505
99* MYB_26560356_Chip-Seq_TH1_Human0.80212488
100* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80063864
101E2F1_18555785_ChIP-Seq_MESCs_Mouse0.79489422
102FOXP3_21729870_ChIP-Seq_TREG_Human0.79321812
103ESR2_21235772_ChIP-Seq_MCF-7_Human0.78209271
104* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.77908204
105LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.77836576
106WT1_19549856_ChIP-ChIP_CCG9911_Human0.77752476
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.76695163
108MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.76316905
109AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76168371
110SCL_19346495_ChIP-Seq_HPC-7_Human0.75848947
111PKCTHETA_26484144_Chip-Seq_BREAST_Human0.75416039
112GATA1_22383799_ChIP-Seq_G1ME_Mouse0.73803148
113FOXA2_19822575_ChIP-Seq_HepG2_Human0.73712415
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73496022
115TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.73257920
116NOTCH1_21737748_ChIP-Seq_TLL_Human0.72319098
117POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.72133148
118CREB1_15753290_ChIP-ChIP_HEK293T_Human0.71986690
119STAT1_20625510_ChIP-Seq_HELA_Human0.71925990
120MYB_26560356_Chip-Seq_TH2_Human0.71203292
121* CIITA_25753668_ChIP-Seq_RAJI_Human0.71168849
122CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.71044786
123* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70810265
124SRF_21415370_ChIP-Seq_HL-1_Mouse0.70308374
125DCP1A_22483619_ChIP-Seq_HELA_Human0.68321881
126* SALL4_22934838_ChIP-ChIP_CD34+_Human0.68235917
127P63_26484246_Chip-Seq_KERATINOCYTES_Human0.68028710
128KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.67331570
129ZFX_18555785_ChIP-Seq_MESCs_Mouse0.66334166
130NANOG_18555785_ChIP-Seq_MESCs_Mouse0.66243591
131* MYC_18940864_ChIP-ChIP_HL60_Human0.65692470
132GATA2_22383799_ChIP-Seq_G1ME_Mouse0.64358476
133ELF1_17652178_ChIP-ChIP_JURKAT_Human0.63242906
134GATA2_21666600_ChIP-Seq_HMVEC_Human0.62533320
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.62531348
136ESR1_15608294_ChIP-ChIP_MCF-7_Human0.61953318
137SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.61546514
138ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.60996085
139ERG_20517297_ChIP-Seq_VCAP_Human0.60650597
140ZNF263_19887448_ChIP-Seq_K562_Human0.60549789
141CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.60130957
142GATA3_24758297_ChIP-Seq_MCF-7_Human0.59969858
143PPAR_26484153_Chip-Seq_NCI-H1993_Human0.59679767
144XRN2_22483619_ChIP-Seq_HELA_Human0.59435556
145CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.59374414
146GATA1_19941827_ChIP-Seq_MEL_Mouse0.58994201
147UTX_26944678_Chip-Seq_JUKART_Human0.58957873
148AR_20517297_ChIP-Seq_VCAP_Human0.58744884
149E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.58561183
150TP63_17297297_ChIP-ChIP_HaCaT_Human0.58524094
151CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.58493600
152MYB_21317192_ChIP-Seq_ERMYB_Mouse0.58382832
153EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.58167404
154MYC_19079543_ChIP-ChIP_MESCs_Mouse0.58024098
155HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.57667286
156GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.57411833
157* RUNX1_22412390_ChIP-Seq_EML_Mouse0.57218406
158EOMES_21245162_ChIP-Seq_HESCs_Human0.57037372
159SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.56523999
160ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.55486436
161PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.55224650
162EST1_17652178_ChIP-ChIP_JURKAT_Human0.55029279
163* MYC_19915707_ChIP-ChIP_AK7_Human0.54445610
164NANOG_20526341_ChIP-Seq_ESCs_Human0.53672416
165OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.53225026
166* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.52916396
167CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.52732305
168* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.52270231
169* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.52233103
170GABP_17652178_ChIP-ChIP_JURKAT_Human0.51672752

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.23852006
2MP0003806_abnormal_nucleotide_metabolis5.12291383
3MP0008057_abnormal_DNA_replication4.37814859
4MP0010094_abnormal_chromosome_stability4.30896774
5MP0005360_urolithiasis4.13147600
6MP0005365_abnormal_bile_salt3.52976160
7MP0003111_abnormal_nucleus_morphology3.52726251
8MP0000920_abnormal_myelination3.44599132
9MP0005085_abnormal_gallbladder_physiolo3.41597911
10MP0003656_abnormal_erythrocyte_physiolo3.37845293
11MP0003077_abnormal_cell_cycle3.36157235
12MP0003195_calcinosis3.23393283
13MP0010352_gastrointestinal_tract_polyps3.12257210
14MP0008875_abnormal_xenobiotic_pharmacok3.09762728
15MP0003186_abnormal_redox_activity2.91592613
16MP0002009_preneoplasia2.91532677
17MP0003693_abnormal_embryo_hatching2.86725490
18MP0004957_abnormal_blastocyst_morpholog2.83806074
19MP0003763_abnormal_thymus_physiology2.69814647
20MP0005464_abnormal_platelet_physiology2.67473932
21MP0000685_abnormal_immune_system2.59708325
22MP0002396_abnormal_hematopoietic_system2.59625472
23MP0009840_abnormal_foam_cell2.58589261
24MP0004147_increased_porphyrin_level2.52518610
25MP0005083_abnormal_biliary_tract2.46565724
26MP0002166_altered_tumor_susceptibility2.40963762
27MP0001666_abnormal_nutrient_absorption2.31152917
28MP0004808_abnormal_hematopoietic_stem2.30998800
29MP0004043_abnormal_pH_regulation2.25771766
30MP0001835_abnormal_antigen_presentation2.25039379
31MP0008007_abnormal_cellular_replicative2.24431172
32MP0005058_abnormal_lysosome_morphology2.23791384
33MP0005332_abnormal_amino_acid2.21400245
34MP0003690_abnormal_glial_cell2.11558710
35MP0003950_abnormal_plasma_membrane2.10722084
36MP0010307_abnormal_tumor_latency2.07851843
37MP0005451_abnormal_body_composition2.07221123
38MP0003136_yellow_coat_color1.97140299
39MP0002398_abnormal_bone_marrow1.93676234
40MP0008058_abnormal_DNA_repair1.89915680
41MP0005408_hypopigmentation1.88293195
42MP0010234_abnormal_vibrissa_follicle1.82551126
43MP0008932_abnormal_embryonic_tissue1.82388010
44MP0005671_abnormal_response_to1.77616198
45MP0002006_tumorigenesis1.76405477
46MP0005645_abnormal_hypothalamus_physiol1.75405250
47MP0001800_abnormal_humoral_immune1.74318243
48MP0000350_abnormal_cell_proliferation1.72330953
49MP0002118_abnormal_lipid_homeostasis1.71244327
50MP0000703_abnormal_thymus_morphology1.70154508
51MP0002722_abnormal_immune_system1.67249483
52MP0010329_abnormal_lipoprotein_level1.66152155
53MP0003252_abnormal_bile_duct1.65795457
54MP0009643_abnormal_urine_homeostasis1.64844353
55MP0003191_abnormal_cellular_cholesterol1.60521378
56MP0008438_abnormal_cutaneous_collagen1.57835275
57MP0003786_premature_aging1.56474768
58MP0000372_irregular_coat_pigmentation1.55107197
59MP0002019_abnormal_tumor_incidence1.54065415
60MP0000465_gastrointestinal_hemorrhage1.51842838
61MP0005636_abnormal_mineral_homeostasis1.51589054
62MP0000689_abnormal_spleen_morphology1.50321831
63MP0000490_abnormal_crypts_of1.49640577
64MP0003868_abnormal_feces_composition1.46058205
65MP0005584_abnormal_enzyme/coenzyme_acti1.37582230
66MP0000015_abnormal_ear_pigmentation1.37414592
67MP0005000_abnormal_immune_tolerance1.37043068
68MP0002429_abnormal_blood_cell1.33415115
69MP0005171_absent_coat_pigmentation1.31721367
70MP0000462_abnormal_digestive_system1.31133306
71MP0000313_abnormal_cell_death1.29365594
72MP0000716_abnormal_immune_system1.26110019
73MP0002295_abnormal_pulmonary_circulatio1.25367746
74MP0004185_abnormal_adipocyte_glucose1.25318852
75MP0002086_abnormal_extraembryonic_tissu1.25228423
76MP0004019_abnormal_vitamin_homeostasis1.25109685
77MP0002452_abnormal_antigen_presenting1.23219418
78MP0004947_skin_inflammation1.22619275
79MP0002420_abnormal_adaptive_immunity1.21939466
80MP0002933_joint_inflammation1.21120433
81MP0004134_abnormal_chest_morphology1.20845595
82MP0003634_abnormal_glial_cell1.18936474
83MP0001730_embryonic_growth_arrest1.18037295
84MP0001764_abnormal_homeostasis1.17914654
85MP0000358_abnormal_cell_content/1.17336378
86MP0001819_abnormal_immune_cell1.17136489
87MP0003011_delayed_dark_adaptation1.17111335
88MP0000609_abnormal_liver_physiology1.16864177
89MP0004381_abnormal_hair_follicle1.16669272
90MP0000569_abnormal_digit_pigmentation1.15607784
91MP0002723_abnormal_immune_serum1.15229951
92MP0001661_extended_life_span1.14624883
93MP0006035_abnormal_mitochondrial_morpho1.12234536
94MP0005387_immune_system_phenotype1.08973442
95MP0001790_abnormal_immune_system1.08973442
96MP0005076_abnormal_cell_differentiation1.08569014
97MP0005319_abnormal_enzyme/_coenzyme1.08353300
98MP0003724_increased_susceptibility_to1.07305116
99MP0005220_abnormal_exocrine_pancreas1.04997805
100MP0001697_abnormal_embryo_size1.04532549
101MP0005380_embryogenesis_phenotype1.02826639
102MP0001672_abnormal_embryogenesis/_devel1.02826639
103MP0004885_abnormal_endolymph1.02629700
104MP0002080_prenatal_lethality1.01579093
105MP0003984_embryonic_growth_retardation1.01161097
106MP0002138_abnormal_hepatobiliary_system0.97630574
107MP0003300_gastrointestinal_ulcer0.97449162
108MP0002088_abnormal_embryonic_growth/wei0.97166366
109MP0001542_abnormal_bone_strength0.96937738
110MP0010155_abnormal_intestine_physiology0.96601764
111MP0009697_abnormal_copulation0.96310526
112MP0000604_amyloidosis0.95953653
113MP0003303_peritoneal_inflammation0.95157597
114MP0002090_abnormal_vision0.93772415
115MP0005310_abnormal_salivary_gland0.92850838
116MP0009765_abnormal_xenobiotic_induced0.92842456
117MP0003718_maternal_effect0.89828854
118MP0001485_abnormal_pinna_reflex0.89363675
119MP0005397_hematopoietic_system_phenotyp0.89349393
120MP0001545_abnormal_hematopoietic_system0.89349393
121MP0003329_amyloid_beta_deposits0.88305842
122MP0006036_abnormal_mitochondrial_physio0.87947561
123MP0002229_neurodegeneration0.87462594
124MP0001727_abnormal_embryo_implantation0.87017704
125MP0006082_CNS_inflammation0.86060117
126MP0005084_abnormal_gallbladder_morpholo0.85823068
127MP0002877_abnormal_melanocyte_morpholog0.85635569
128MP0009763_increased_sensitivity_to0.85403866
129MP0001915_intracranial_hemorrhage0.83965790
130MP0005621_abnormal_cell_physiology0.82497174
131MP0003566_abnormal_cell_adhesion0.82228757
132MP0001905_abnormal_dopamine_level0.82038100
133MP0005384_cellular_phenotype0.81481733
134MP0001765_abnormal_ion_homeostasis0.77939228
135MP0003453_abnormal_keratinocyte_physiol0.77328901
136MP0003183_abnormal_peptide_metabolism0.77304344
137MP0008469_abnormal_protein_level0.76139811
138MP0010678_abnormal_skin_adnexa0.76089436
139MP0003075_altered_response_to0.75521835
140MP0005551_abnormal_eye_electrophysiolog0.75501575
141MP0002084_abnormal_developmental_patter0.74778493
142MP0008260_abnormal_autophagy0.73641299
143MP0001533_abnormal_skeleton_physiology0.73189452
144MP0006072_abnormal_retinal_apoptosis0.72506423
145MP0009384_cardiac_valve_regurgitation0.71920362
146MP0001851_eye_inflammation0.71400088
147MP0006054_spinal_hemorrhage0.70762364
148MP0005381_digestive/alimentary_phenotyp0.70640600
149MP0005164_abnormal_response_to0.70430738
150MP0005501_abnormal_skin_physiology0.69416193
151MP0001879_abnormal_lymphatic_vessel0.69044014
152MP0001191_abnormal_skin_condition0.68615007
153MP0001845_abnormal_inflammatory_respons0.68594865
154MP0005623_abnormal_meninges_morphology0.67999479
155MP0009764_decreased_sensitivity_to0.67546125
156MP0002419_abnormal_innate_immunity0.67122053
157MP0001216_abnormal_epidermal_layer0.66956967
158MP0009931_abnormal_skin_appearance0.66749505
159MP0002148_abnormal_hypersensitivity_rea0.66301571
160MP0008004_abnormal_stomach_pH0.65945492
161MP0009278_abnormal_bone_marrow0.65689508
162MP0001944_abnormal_pancreas_morphology0.65037833
163MP0001986_abnormal_taste_sensitivity0.64779636
164MP0001958_emphysema0.63434284
165MP0000230_abnormal_systemic_arterial0.63345676
166MP0009333_abnormal_splenocyte_physiolog0.63334419
167MP0002405_respiratory_system_inflammati0.62660306
168MP0002078_abnormal_glucose_homeostasis0.62455386
169MP0005025_abnormal_response_to0.61370678
170MP0005410_abnormal_fertilization0.61130006
171MP0004142_abnormal_muscle_tone0.61062306
172MP0005187_abnormal_penis_morphology0.60906973
173MP0002095_abnormal_skin_pigmentation0.60853073
174MP0005379_endocrine/exocrine_gland_phen0.60758239
175MP0005253_abnormal_eye_physiology0.59917988
176MP0002693_abnormal_pancreas_physiology0.59735123
177MP0000762_abnormal_tongue_morphology0.59468510
178MP0005376_homeostasis/metabolism_phenot0.59267120
179MP0005647_abnormal_sex_gland0.58934380
180MP0003795_abnormal_bone_structure0.58880851
181MP0009642_abnormal_blood_homeostasis0.57549861
182MP0002136_abnormal_kidney_physiology0.57545834
183MP0002896_abnormal_bone_mineralization0.57411309
184MP0001756_abnormal_urination0.56740278
185MP0000598_abnormal_liver_morphology0.56734376
186MP0000467_abnormal_esophagus_morphology0.55384480
187MP0000647_abnormal_sebaceous_gland0.55151948

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)6.33583419
2IgA deficiency (HP:0002720)6.06135374
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.25082111
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.70296247
5Colitis (HP:0002583)4.60641295
6Intrahepatic cholestasis (HP:0001406)4.60562896
7Chromsome breakage (HP:0040012)4.32192356
8Gastrointestinal stroma tumor (HP:0100723)3.72664367
9Xanthomatosis (HP:0000991)3.59336355
10B lymphocytopenia (HP:0010976)3.52533872
11Cellulitis (HP:0100658)3.47312931
12Autoimmune hemolytic anemia (HP:0001890)3.33970915
13Thyroiditis (HP:0100646)3.24262365
14Neurofibrillary tangles (HP:0002185)3.22936686
15Prolonged partial thromboplastin time (HP:0003645)3.22523169
16Parakeratosis (HP:0001036)3.19391119
17Abnormal platelet volume (HP:0011876)3.18594247
18Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.18375806
19Increased mean platelet volume (HP:0011877)3.16806295
20Degeneration of the lateral corticospinal tracts (HP:0002314)3.12572889
21Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.12572889
22Abnormality of B cell number (HP:0010975)3.11543697
23Hypoglycemic coma (HP:0001325)3.00806671
24Abnormality of chromosome stability (HP:0003220)2.97268383
25Deep venous thrombosis (HP:0002625)2.94417733
26Inflammation of the large intestine (HP:0002037)2.92433356
27Renal Fanconi syndrome (HP:0001994)2.91637997
28Nephroblastoma (Wilms tumor) (HP:0002667)2.90774572
29Hyperlipoproteinemia (HP:0010980)2.89121708
30Abnormal tarsal ossification (HP:0008369)2.85512340
31Recurrent bronchitis (HP:0002837)2.85168608
32Recurrent sinusitis (HP:0011108)2.85085130
33Hyperbilirubinemia (HP:0002904)2.84469915
34Fat malabsorption (HP:0002630)2.84328976
35Petechiae (HP:0000967)2.82496069
36Squamous cell carcinoma (HP:0002860)2.79597267
37Acanthocytosis (HP:0001927)2.75510443
38Agammaglobulinemia (HP:0004432)2.75492086
39Hypoglycemic seizures (HP:0002173)2.73910929
40Recurrent viral infections (HP:0004429)2.71614614
41Lymphopenia (HP:0001888)2.70900514
42Abnormality of the preputium (HP:0100587)2.70690277
43Vacuolated lymphocytes (HP:0001922)2.70674903
44Gastrointestinal inflammation (HP:0004386)2.68708046
45Embryonal renal neoplasm (HP:0011794)2.66649886
46Spastic paraparesis (HP:0002313)2.66595787
47Abnormality of cells of the lymphoid lineage (HP:0012140)2.63560624
48Abnormality of monocarboxylic acid metabolism (HP:0010996)2.63333622
49Lipid accumulation in hepatocytes (HP:0006561)2.62734389
50Prolonged bleeding time (HP:0003010)2.62723107
51Medulloblastoma (HP:0002885)2.60576403
52Lymphoma (HP:0002665)2.60176091
53Steatorrhea (HP:0002570)2.59433633
54Axonal loss (HP:0003447)2.57838035
55Chronic diarrhea (HP:0002028)2.56393599
56Acute encephalopathy (HP:0006846)2.54878504
57Abnormality of urine glucose concentration (HP:0011016)2.53822647
58Glycosuria (HP:0003076)2.53822647
59Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.53264501
60Hepatic necrosis (HP:0002605)2.50596317
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.50488082
62Myelodysplasia (HP:0002863)2.49631351
63Increased hepatocellular lipid droplets (HP:0006565)2.49335795
64Acute lymphatic leukemia (HP:0006721)2.48925426
65Erythema (HP:0010783)2.48361627
66Abnormality of fatty-acid metabolism (HP:0004359)2.47100030
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.46387585
68Abnormality of the fingertips (HP:0001211)2.44984742
69Cerebral edema (HP:0002181)2.44303728
70Viral hepatitis (HP:0006562)2.43984660
71Poikilocytosis (HP:0004447)2.43892625
72Dry hair (HP:0011359)2.43493353
73Generalized aminoaciduria (HP:0002909)2.43396843
74Abnormality of the heme biosynthetic pathway (HP:0010472)2.42754985
75Abnormality of methionine metabolism (HP:0010901)2.40258941
76Eczematoid dermatitis (HP:0000976)2.39840520
77Sensory axonal neuropathy (HP:0003390)2.39676368
78Stridor (HP:0010307)2.39103721
79Abnormality of the prostate (HP:0008775)2.36088729
80Osteomyelitis (HP:0002754)2.35425851
81Prostate neoplasm (HP:0100787)2.33703780
82Abnormal gallbladder morphology (HP:0012437)2.32544087
83Hypobetalipoproteinemia (HP:0003563)2.32025466
84Symptomatic seizures (HP:0011145)2.31999960
85Hepatocellular necrosis (HP:0001404)2.31214404
86Epiphyseal dysplasia (HP:0002656)2.30532206
87Conjugated hyperbilirubinemia (HP:0002908)2.30330001
88Ketosis (HP:0001946)2.29829120
89Abnormality of renal resorption (HP:0011038)2.29596026
90Basal cell carcinoma (HP:0002671)2.29088327
91Panhypogammaglobulinemia (HP:0003139)2.27957912
92Subacute progressive viral hepatitis (HP:0006572)2.27917759
93Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.27742489
94IgG deficiency (HP:0004315)2.27728644
95Mitochondrial inheritance (HP:0001427)2.27480018
96Acute necrotizing encephalopathy (HP:0006965)2.26503161
97Meningitis (HP:0001287)2.26231405
98Abnormality of the ileum (HP:0001549)2.25568514
99Menorrhagia (HP:0000132)2.25023090
100Dyschromatopsia (HP:0007641)2.24276957
101Hypokalemic alkalosis (HP:0001949)2.23453869
102Abnormality of glutamine family amino acid metabolism (HP:0010902)2.22216502
103Joint hemorrhage (HP:0005261)2.22015935
104Increased intramyocellular lipid droplets (HP:0012240)2.20186326
105Protuberant abdomen (HP:0001538)2.19981639
106Abnormality of serine family amino acid metabolism (HP:0010894)2.19235824
107Abnormality of glycine metabolism (HP:0010895)2.19235824
108Epistaxis (HP:0000421)2.18864365
109Increased muscle lipid content (HP:0009058)2.17786984
110Orthostatic hypotension (HP:0001278)2.16897934
111Clubbing of toes (HP:0100760)2.15114121
112Amyloidosis (HP:0011034)2.15071938
113Prominent nose (HP:0000448)2.14939396
114Abnormality of T cell physiology (HP:0011840)2.14926123
115Hyperinsulinemic hypoglycemia (HP:0000825)2.13819045
116Abnormality of glycolysis (HP:0004366)2.13784008
117Increased serum pyruvate (HP:0003542)2.13784008
118Papillary thyroid carcinoma (HP:0002895)2.13581343
119Abnormality of the carotid arteries (HP:0005344)2.13434041
120Combined immunodeficiency (HP:0005387)2.13327033
121Vascular calcification (HP:0004934)2.12564189
122Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.12192525
123Congenital ichthyosiform erythroderma (HP:0007431)2.11995601
124Leiomyosarcoma (HP:0100243)2.11959210
125Uterine leiomyosarcoma (HP:0002891)2.11959210
126Leukodystrophy (HP:0002415)2.11459346
127Increased neuronal autofluorescent lipopigment (HP:0002074)2.07858385
128Deep philtrum (HP:0002002)2.06758185
129Onycholysis (HP:0001806)2.06615785
130Hepatosplenomegaly (HP:0001433)2.06003471
131Hepatitis (HP:0012115)2.05705583
132Paraparesis (HP:0002385)2.04552194
133Abnormal platelet function (HP:0011869)2.03404061
134Impaired platelet aggregation (HP:0003540)2.03404061
135Spontaneous hematomas (HP:0007420)2.03341671
136Severe combined immunodeficiency (HP:0004430)2.03253175
137Abnormal foot bone ossification (HP:0010675)2.02946591
138Abnormality of the intrinsic pathway (HP:0010989)2.00375335
139Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.00115831
140Abnormality of the common coagulation pathway (HP:0010990)1.99777673
141Abnormality of sulfur amino acid metabolism (HP:0004339)1.98279715
142Purpura (HP:0000979)1.98056242
143Hyperphosphaturia (HP:0003109)1.97952294
144Beaking of vertebral bodies (HP:0004568)1.97862525
145Interstitial pulmonary disease (HP:0006530)1.97703009
146Leukopenia (HP:0001882)1.97297929
147Patchy hypopigmentation of hair (HP:0011365)1.97079423
148Abnormal mitochondria in muscle tissue (HP:0008316)1.96482428
149Ketoacidosis (HP:0001993)1.95925509
150Dicarboxylic aciduria (HP:0003215)1.95915637
151Abnormality of dicarboxylic acid metabolism (HP:0010995)1.95915637
152Cerebral inclusion bodies (HP:0100314)1.95832559
153Ileus (HP:0002595)1.94248904
154Hypolipoproteinemia (HP:0010981)1.94133023
155Meckel diverticulum (HP:0002245)1.93810398
156Irregular epiphyses (HP:0010582)1.93161551
157Small intestinal stenosis (HP:0012848)1.92486552
158Duodenal stenosis (HP:0100867)1.92486552
159Cholelithiasis (HP:0001081)1.92369930
160Short 4th metacarpal (HP:0010044)1.91940149
161Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.91940149
162Septate vagina (HP:0001153)1.90397030
163Cardiovascular calcification (HP:0011915)1.90206887
164Progressive macrocephaly (HP:0004481)1.89985085
165Ridged nail (HP:0001807)1.89928761
166Episodic fever (HP:0001954)1.89913829
167Small epiphyses (HP:0010585)1.89613620
168Hypochromic microcytic anemia (HP:0004840)1.89251030
169Bladder carcinoma (HP:0002862)1.88727855
170Bladder neoplasm (HP:0009725)1.88727855
171Abnormal hemoglobin (HP:0011902)1.88500946
172Hypomagnesemia (HP:0002917)1.88066581
173Alkalosis (HP:0001948)1.87742067
174Cupped ribs (HP:0000887)1.86995499
175Metabolic alkalosis (HP:0200114)1.84820425
176Hyperglycinuria (HP:0003108)1.84566196
177Epidermoid cyst (HP:0200040)1.84025747
178Abnormality of magnesium homeostasis (HP:0004921)1.83900358
179Oral leukoplakia (HP:0002745)1.83637390
180Rickets (HP:0002748)1.83595003
181Micronodular cirrhosis (HP:0001413)1.83394557
182Abnormality of pyrimidine metabolism (HP:0004353)1.82983620
183Transitional cell carcinoma of the bladder (HP:0006740)1.82480722
184Recurrent bacterial skin infections (HP:0005406)1.81957693
185Birth length less than 3rd percentile (HP:0003561)1.81532178
186Progressive external ophthalmoplegia (HP:0000590)1.81049429
187Conjunctival telangiectasia (HP:0000524)1.80770504
188Dysautonomia (HP:0002459)1.79798338
189Hypergonadotropic hypogonadism (HP:0000815)1.77946322
190Cafe-au-lait spot (HP:0000957)1.77629973
191Gastrointestinal carcinoma (HP:0002672)1.73312766
192Malignant gastrointestinal tract tumors (HP:0006749)1.73312766
193Spastic diplegia (HP:0001264)1.71045029
194Acute myeloid leukemia (HP:0004808)1.70713156
195Entropion (HP:0000621)1.70703019
196Ankyloglossia (HP:0010296)1.70576399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.62129143
2ZAK4.23244246
3STK393.90251775
4PBK3.52909665
5OXSR12.97966388
6EPHB12.73534425
7MET2.50851419
8MAPK152.46530326
9RPS6KA52.41954626
10VRK12.23178413
11WNK42.22530584
12PKN12.22488817
13MST42.19712899
14BCKDK2.09579318
15MAP2K22.00497353
16MAPKAPK51.94429995
17BCR1.93272861
18AURKA1.87305909
19BUB11.83097768
20STK41.80329322
21CDC71.72101940
22BMPR1B1.68742693
23STK161.65635789
24SMG11.59445223
25TNIK1.52740117
26CSNK1G31.38648289
27MST1R1.36695818
28CHEK21.32487092
29CSNK1A1L1.31343720
30AURKB1.29339120
31TAF11.16519540
32CSNK1G11.15580403
33EEF2K1.15208202
34BRSK21.12346564
35TAOK31.10712833
36CDK191.08788515
37INSRR1.07239324
38DAPK31.00424577
39ERBB41.00004200
40WNK10.98995576
41MAP3K100.97781611
42TRPM70.96008035
43LIMK10.95847565
44PIM20.91057200
45DYRK30.89827746
46EPHA20.88157059
47NEK60.87003364
48BMPR20.86828705
49FGFR20.85174940
50PRKCQ0.85145785
51PIM10.84884750
52PIK3CA0.84440761
53CDK90.83430299
54TTK0.81579158
55CAMK2D0.80885610
56NEK10.79660813
57RPS6KB20.79365089
58PIK3CG0.79066677
59CSNK1G20.77863170
60BRAF0.77066195
61CDK120.76902211
62ABL20.73426453
63BLK0.73347899
64SCYL20.72055209
65SYK0.71817003
66MAP3K140.71625350
67MUSK0.71011651
68CCNB10.70859083
69SGK4940.70673032
70SGK2230.70673032
71NME20.68924817
72PRKG20.68878276
73CAMK2B0.68473733
74ERN10.68414273
75MAP3K20.68291034
76TESK20.65768611
77IKBKB0.65292699
78ARAF0.63664326
79SRPK10.63414589
80DYRK1B0.61353956
81CAMK2G0.60913991
82CDK80.60632590
83WNK30.59942188
84ATR0.58791298
85TRIB30.58677865
86GSK3A0.58047268
87NTRK10.57252992
88ROCK20.55520047
89IRAK40.51860761
90AKT20.49076039
91IRAK10.48735332
92MAP2K30.47842353
93CDK70.47312963
94NLK0.46716998
95PRKAA10.46593609
96DYRK20.46567534
97HIPK20.45855440
98MAPK110.45851544
99MELK0.45625589
100IKBKE0.44715058
101PLK40.44388663
102EPHA30.43362869
103FLT30.42909046
104EIF2AK30.42688717
105PLK10.41370646
106WEE10.41262123
107RAF10.40643084
108MAP2K10.39604752
109MAP2K70.39322696
110FGR0.39032426
111TEC0.38987458
112JAK20.38892765
113CDK60.38738865
114MAP3K80.38319173
115CLK10.37808568
116PAK30.37236840
117GRK10.37149514
118LYN0.36026348
119ICK0.35211656
120NEK90.35174910
121PRKD10.34827678
122PRPF4B0.34755806
123CHEK10.34432943
124ROCK10.33866324
125MAPK70.33256335
126TBK10.32918551
127MAP3K30.32766569
128CAMKK20.31413394
129PAK10.31364491
130PKN20.31126737
131CDK40.30929981
132MAPK40.30887331
133MAP3K40.30804559
134RIPK40.30144648
135ITK0.29940206
136FRK0.28416410
137PRKCD0.28337994
138EIF2AK10.28140847
139ATM0.27743399
140CSNK1D0.26474064
141HCK0.26066914
142BTK0.25185324
143NUAK10.25163935
144PLK30.24799264
145PDPK10.24665784
146RET0.24522120
147IRAK30.24254634
148ERBB30.23331979
149PRKCE0.23310400
150CSF1R0.23079118
151MAP4K10.22629741
152NEK20.22269157
153STK30.21587868
154CDK20.21041694
155STK240.20618824
156ILK0.18915498
157BRSK10.17669508
158TTN0.15977024
159CAMK40.14809850
160EIF2AK20.14478539
161CDK10.12436852
162TSSK60.11022569
163MAP2K40.10614419

Predicted pathways (KEGG)

RankGene SetZ-score
1* Systemic lupus erythematosus_Homo sapiens_hsa053224.69791651
2Sulfur metabolism_Homo sapiens_hsa009203.32115284
3Steroid biosynthesis_Homo sapiens_hsa001003.18648810
4Fatty acid elongation_Homo sapiens_hsa000622.77484904
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.71897419
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.64536908
7Protein export_Homo sapiens_hsa030602.56083030
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.43982595
9* Alcoholism_Homo sapiens_hsa050342.42159260
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.37289818
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.32983104
12DNA replication_Homo sapiens_hsa030302.25497614
13Histidine metabolism_Homo sapiens_hsa003402.19626964
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05667664
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03276052
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.01066242
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.98764165
18Folate biosynthesis_Homo sapiens_hsa007901.94032798
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.89759548
20Peroxisome_Homo sapiens_hsa041461.86796525
21Nitrogen metabolism_Homo sapiens_hsa009101.86331944
22Butanoate metabolism_Homo sapiens_hsa006501.85195179
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81788098
24Mismatch repair_Homo sapiens_hsa034301.71425527
25Fatty acid degradation_Homo sapiens_hsa000711.61444400
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58410443
27Oxidative phosphorylation_Homo sapiens_hsa001901.58239828
28Tryptophan metabolism_Homo sapiens_hsa003801.56690759
29Chemical carcinogenesis_Homo sapiens_hsa052041.56348629
30Sulfur relay system_Homo sapiens_hsa041221.53232662
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51615166
32Fatty acid metabolism_Homo sapiens_hsa012121.45521336
33Propanoate metabolism_Homo sapiens_hsa006401.41063006
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.40895951
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38766760
36Arginine and proline metabolism_Homo sapiens_hsa003301.34626824
37Ether lipid metabolism_Homo sapiens_hsa005651.33828691
38Complement and coagulation cascades_Homo sapiens_hsa046101.33751806
39Glutathione metabolism_Homo sapiens_hsa004801.31743930
40Primary immunodeficiency_Homo sapiens_hsa053401.30275175
41Cell cycle_Homo sapiens_hsa041101.29995070
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28641575
43Vitamin B6 metabolism_Homo sapiens_hsa007501.28088388
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.21843172
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15013256
46Retinol metabolism_Homo sapiens_hsa008301.13405555
47Tyrosine metabolism_Homo sapiens_hsa003501.11182368
48PPAR signaling pathway_Homo sapiens_hsa033201.10288038
49Linoleic acid metabolism_Homo sapiens_hsa005911.08622660
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06442484
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05561508
52Parkinsons disease_Homo sapiens_hsa050121.04889950
53Sphingolipid metabolism_Homo sapiens_hsa006001.04791512
54B cell receptor signaling pathway_Homo sapiens_hsa046621.04497467
55Asthma_Homo sapiens_hsa053101.04377871
56beta-Alanine metabolism_Homo sapiens_hsa004101.03465333
57Allograft rejection_Homo sapiens_hsa053301.02129098
58Selenocompound metabolism_Homo sapiens_hsa004501.01639773
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01160850
60Nucleotide excision repair_Homo sapiens_hsa034200.99984180
61Homologous recombination_Homo sapiens_hsa034400.99817902
62Autoimmune thyroid disease_Homo sapiens_hsa053200.98698022
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.97500995
64Starch and sucrose metabolism_Homo sapiens_hsa005000.97031308
65ABC transporters_Homo sapiens_hsa020100.96097604
66Caffeine metabolism_Homo sapiens_hsa002320.94643714
67Arginine biosynthesis_Homo sapiens_hsa002200.91826822
68Fanconi anemia pathway_Homo sapiens_hsa034600.90805050
69Fat digestion and absorption_Homo sapiens_hsa049750.89411455
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89309893
71Graft-versus-host disease_Homo sapiens_hsa053320.87159412
72p53 signaling pathway_Homo sapiens_hsa041150.84926975
73One carbon pool by folate_Homo sapiens_hsa006700.83664753
74Pyruvate metabolism_Homo sapiens_hsa006200.83292413
75Phenylalanine metabolism_Homo sapiens_hsa003600.81631452
76Non-small cell lung cancer_Homo sapiens_hsa052230.80768212
77Alzheimers disease_Homo sapiens_hsa050100.80632833
78Base excision repair_Homo sapiens_hsa034100.80380252
79Arachidonic acid metabolism_Homo sapiens_hsa005900.79351213
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79345540
81Vitamin digestion and absorption_Homo sapiens_hsa049770.76930934
82Metabolic pathways_Homo sapiens_hsa011000.72062760
83Malaria_Homo sapiens_hsa051440.71267662
84Other glycan degradation_Homo sapiens_hsa005110.70760096
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70554266
86Pancreatic cancer_Homo sapiens_hsa052120.69253354
87Lysosome_Homo sapiens_hsa041420.67456340
88Type I diabetes mellitus_Homo sapiens_hsa049400.66049303
89* Viral carcinogenesis_Homo sapiens_hsa052030.66021178
90Viral myocarditis_Homo sapiens_hsa054160.62829098
91Bile secretion_Homo sapiens_hsa049760.61671882
92Staphylococcus aureus infection_Homo sapiens_hsa051500.60851662
93Herpes simplex infection_Homo sapiens_hsa051680.59311728
94Thyroid cancer_Homo sapiens_hsa052160.58971617
95Leishmaniasis_Homo sapiens_hsa051400.58896037
96Chronic myeloid leukemia_Homo sapiens_hsa052200.58309556
97Pyrimidine metabolism_Homo sapiens_hsa002400.55387142
98Platelet activation_Homo sapiens_hsa046110.55298386
99Epstein-Barr virus infection_Homo sapiens_hsa051690.55031084
100Small cell lung cancer_Homo sapiens_hsa052220.51800586
101Hematopoietic cell lineage_Homo sapiens_hsa046400.51018925
102HTLV-I infection_Homo sapiens_hsa051660.50089642
103Huntingtons disease_Homo sapiens_hsa050160.50059091
104Antigen processing and presentation_Homo sapiens_hsa046120.49304192
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49163439
106RNA transport_Homo sapiens_hsa030130.48598706
107Glycerolipid metabolism_Homo sapiens_hsa005610.48111501
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47441202
109Glioma_Homo sapiens_hsa052140.45412696
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.45380198
111Colorectal cancer_Homo sapiens_hsa052100.44312247
112Apoptosis_Homo sapiens_hsa042100.44097489
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42541699
114Hepatitis B_Homo sapiens_hsa051610.40215081
115Measles_Homo sapiens_hsa051620.39657545
116Mineral absorption_Homo sapiens_hsa049780.39436455
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39188902
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38516407
119Influenza A_Homo sapiens_hsa051640.37622094
120Endometrial cancer_Homo sapiens_hsa052130.37274623
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36061763
122Spliceosome_Homo sapiens_hsa030400.35657280
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.35495193
124Rheumatoid arthritis_Homo sapiens_hsa053230.34982548
125Vibrio cholerae infection_Homo sapiens_hsa051100.34569644
126Acute myeloid leukemia_Homo sapiens_hsa052210.33878634
127Bladder cancer_Homo sapiens_hsa052190.33343814
128Protein digestion and absorption_Homo sapiens_hsa049740.33094923
129MicroRNAs in cancer_Homo sapiens_hsa052060.31963226
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30520694
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30335696
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29932896
133RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29743379
134Prostate cancer_Homo sapiens_hsa052150.29487841
135Regulation of autophagy_Homo sapiens_hsa041400.29437007
136Inositol phosphate metabolism_Homo sapiens_hsa005620.29326486
137Toxoplasmosis_Homo sapiens_hsa051450.28069064
138Pentose phosphate pathway_Homo sapiens_hsa000300.27745156
139Purine metabolism_Homo sapiens_hsa002300.27413858
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.26261796
141Carbon metabolism_Homo sapiens_hsa012000.26249788
142Non-homologous end-joining_Homo sapiens_hsa034500.26225253
143Phagosome_Homo sapiens_hsa041450.26096038
144Fatty acid biosynthesis_Homo sapiens_hsa000610.24092927
145Melanoma_Homo sapiens_hsa052180.23270286
146Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23145633
147Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21287533
148Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20471747
149Ribosome_Homo sapiens_hsa030100.20411123
150Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20186844
151T cell receptor signaling pathway_Homo sapiens_hsa046600.19368841
152HIF-1 signaling pathway_Homo sapiens_hsa040660.18407856
153Collecting duct acid secretion_Homo sapiens_hsa049660.18091306
154Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.17978466
155N-Glycan biosynthesis_Homo sapiens_hsa005100.17717475
156Toll-like receptor signaling pathway_Homo sapiens_hsa046200.17271992
157ECM-receptor interaction_Homo sapiens_hsa045120.17097795
158Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15391907
159Transcriptional misregulation in cancer_Homo sapiens_hsa052020.13865209
160Galactose metabolism_Homo sapiens_hsa000520.13536061
161Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13405630
162Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13174209
163Shigellosis_Homo sapiens_hsa051310.13098211
164Glycerophospholipid metabolism_Homo sapiens_hsa005640.12686212
165RNA polymerase_Homo sapiens_hsa030200.12543563
166Renin-angiotensin system_Homo sapiens_hsa046140.11645112
167ErbB signaling pathway_Homo sapiens_hsa040120.11408861
168Tuberculosis_Homo sapiens_hsa051520.10915027
169Osteoclast differentiation_Homo sapiens_hsa043800.10325197
170Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10220477
171Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.10142743
172FoxO signaling pathway_Homo sapiens_hsa040680.09851644
173Prion diseases_Homo sapiens_hsa050200.09698733
174mRNA surveillance pathway_Homo sapiens_hsa030150.08462010
175RNA degradation_Homo sapiens_hsa030180.07940408
176Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.07292137
177Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.06824032
178Biosynthesis of amino acids_Homo sapiens_hsa012300.06312165
179Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.05804498
180Neurotrophin signaling pathway_Homo sapiens_hsa047220.05758212
181Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.05646944
182Pancreatic secretion_Homo sapiens_hsa049720.03582688

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