HIST1H2BE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. The protein has antibacterial and antifungal antimicrobial activity. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome assembly (GO:0006335)9.15233199
2DNA replication-dependent nucleosome organization (GO:0034723)9.15233199
3chromatin assembly (GO:0031497)8.21789435
4nucleosome assembly (GO:0006334)7.40439069
5regulation of histone H3-K9 methylation (GO:0051570)7.07366422
6antibacterial humoral response (GO:0019731)6.75180987
7innate immune response in mucosa (GO:0002227)6.50937141
8nucleosome organization (GO:0034728)6.33400735
9antimicrobial humoral response (GO:0019730)6.24996411
10protein-DNA complex assembly (GO:0065004)6.23256497
11nuclear pore complex assembly (GO:0051292)5.79042312
12chromatin assembly or disassembly (GO:0006333)5.73593618
13nuclear pore organization (GO:0006999)5.63548317
14protein-DNA complex subunit organization (GO:0071824)5.51677915
15protein localization to kinetochore (GO:0034501)5.31207388
16mucosal immune response (GO:0002385)5.19829175
17DNA unwinding involved in DNA replication (GO:0006268)5.19669962
18mitotic chromosome condensation (GO:0007076)5.16446291
19organ or tissue specific immune response (GO:0002251)4.90908920
20sister chromatid segregation (GO:0000819)4.78024066
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.76991647
22folic acid-containing compound biosynthetic process (GO:0009396)4.68190071
23protein localization to chromosome, centromeric region (GO:0071459)4.59745583
24pore complex assembly (GO:0046931)4.48013657
25protoporphyrinogen IX metabolic process (GO:0046501)4.42237941
26positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.28277209
27positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.28277209
28positive regulation of mitotic sister chromatid separation (GO:1901970)4.28277209
29regulation of centriole replication (GO:0046599)4.26473287
30chromatin remodeling at centromere (GO:0031055)4.20537347
31CENP-A containing nucleosome assembly (GO:0034080)4.19320388
32mitotic sister chromatid segregation (GO:0000070)4.17428280
33DNA double-strand break processing (GO:0000729)4.10526623
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.08633509
35DNA replication initiation (GO:0006270)4.04952040
36positive regulation of chromosome segregation (GO:0051984)4.04691678
37regulation of DNA endoreduplication (GO:0032875)4.03381095
38protoporphyrinogen IX biosynthetic process (GO:0006782)3.97482698
39dosage compensation (GO:0007549)3.93724469
40regulation of gene silencing (GO:0060968)3.84243361
41mitotic nuclear envelope disassembly (GO:0007077)3.80390614
42negative regulation of histone methylation (GO:0031061)3.77570429
43protein K6-linked ubiquitination (GO:0085020)3.74684052
44DNA duplex unwinding (GO:0032508)3.74551955
45IMP biosynthetic process (GO:0006188)3.72932840
46DNA geometric change (GO:0032392)3.72614013
47regulation of centrosome cycle (GO:0046605)3.65937425
48regulation of sister chromatid cohesion (GO:0007063)3.65077807
49DNA replication-independent nucleosome organization (GO:0034724)3.63064004
50DNA replication-independent nucleosome assembly (GO:0006336)3.63064004
51nuclear envelope disassembly (GO:0051081)3.62178425
52membrane disassembly (GO:0030397)3.62178425
53somatic diversification of immune receptors via somatic mutation (GO:0002566)3.61421963
54somatic hypermutation of immunoglobulin genes (GO:0016446)3.61421963
55pre-miRNA processing (GO:0031054)3.60178415
56DNA strand elongation involved in DNA replication (GO:0006271)3.57839559
57replication fork processing (GO:0031297)3.50219674
58regulation of centrosome duplication (GO:0010824)3.49408581
59double-strand break repair via nonhomologous end joining (GO:0006303)3.48131959
60non-recombinational repair (GO:0000726)3.48131959
61mitotic sister chromatid cohesion (GO:0007064)3.46730810
62positive regulation of histone methylation (GO:0031062)3.45338910
63negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.44608064
64mitotic recombination (GO:0006312)3.44277063
65kinetochore organization (GO:0051383)3.44272091
66DNA strand elongation (GO:0022616)3.39658981
67viral mRNA export from host cell nucleus (GO:0046784)3.38450737
68microtubule depolymerization (GO:0007019)3.38382574
69chromosome condensation (GO:0030261)3.37939034
70histone exchange (GO:0043486)3.37012269
71meiotic chromosome segregation (GO:0045132)3.36769212
72regulation of megakaryocyte differentiation (GO:0045652)3.36129776
73attachment of spindle microtubules to kinetochore (GO:0008608)3.35339593
74regulation of RNA export from nucleus (GO:0046831)3.34423372
75telomere maintenance via semi-conservative replication (GO:0032201)3.34357871
76regulation of helicase activity (GO:0051095)3.31164114
77IMP metabolic process (GO:0046040)3.29046134
78translesion synthesis (GO:0019985)3.28514470
79maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.28224464
80spindle assembly involved in mitosis (GO:0090307)3.27085968
81regulation of spindle organization (GO:0090224)3.23271096
82DNA replication checkpoint (GO:0000076)3.22098978
83DNA topological change (GO:0006265)3.17619502
84protein localization to chromosome (GO:0034502)3.15232240
85regulation of translational fidelity (GO:0006450)3.14079363
86telomere maintenance via recombination (GO:0000722)3.13710984
87regulation of chromosome segregation (GO:0051983)3.12543000
88regulation of posttranscriptional gene silencing (GO:0060147)3.12266619
89regulation of gene silencing by miRNA (GO:0060964)3.12266619
90regulation of gene silencing by RNA (GO:0060966)3.12266619
91defense response to Gram-positive bacterium (GO:0050830)3.11601562
92regulation of mitotic spindle organization (GO:0060236)3.10197699
93V(D)J recombination (GO:0033151)3.09960258
94establishment of integrated proviral latency (GO:0075713)3.07973004
95DNA synthesis involved in DNA repair (GO:0000731)3.07169563
96microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.05805096
97mitotic metaphase plate congression (GO:0007080)3.05373274
98DNA conformation change (GO:0071103)3.05135853
99negative regulation of chromosome segregation (GO:0051985)3.03351051
100regulation of mitotic metaphase/anaphase transition (GO:0030071)3.03134909
101telomere maintenance (GO:0000723)3.02782276
102positive regulation of histone H3-K4 methylation (GO:0051571)3.02392698
103erythrocyte maturation (GO:0043249)3.02386024
104metaphase plate congression (GO:0051310)3.01138996
105somatic cell DNA recombination (GO:0016444)3.00752181
106somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.00752181
107negative regulation of mitotic sister chromatid separation (GO:2000816)3.00170648
108negative regulation of sister chromatid segregation (GO:0033046)3.00170648
109negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00170648
110negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.00170648
111negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00170648
112postreplication repair (GO:0006301)2.99607736
113telomere organization (GO:0032200)2.99022281
114ATP-dependent chromatin remodeling (GO:0043044)2.97516711
115spindle checkpoint (GO:0031577)2.96430671
116regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94161848
117regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.93210457
118regulation of mitotic spindle checkpoint (GO:1903504)2.93210457
119histone lysine demethylation (GO:0070076)2.93126468
120regulation of sister chromatid segregation (GO:0033045)2.91676145
121regulation of mitotic sister chromatid separation (GO:0010965)2.91676145
122regulation of mitotic sister chromatid segregation (GO:0033047)2.91676145
123DNA strand renaturation (GO:0000733)2.91585824
124nucleotide-excision repair, DNA gap filling (GO:0006297)2.91531620
125regulation of histone methylation (GO:0031060)2.91265911
126somatic recombination of immunoglobulin gene segments (GO:0016447)2.90831715
127chromosome segregation (GO:0007059)2.90648002
128establishment of chromosome localization (GO:0051303)2.90176235
129histone demethylation (GO:0016577)2.89868119
130kinetochore assembly (GO:0051382)2.88985476
131DNA packaging (GO:0006323)2.88653855
132somatic diversification of immune receptors (GO:0002200)2.86853478
133DNA ligation (GO:0006266)2.85670188
134mitotic spindle checkpoint (GO:0071174)2.83348636
135mitotic spindle assembly checkpoint (GO:0007094)2.82381435
136replicative senescence (GO:0090399)2.81188843
137ncRNA catabolic process (GO:0034661)2.80805314
138protein prenylation (GO:0018342)2.78508899
139prenylation (GO:0097354)2.78508899
140spindle assembly checkpoint (GO:0071173)2.78228503
141establishment of viral latency (GO:0019043)2.77702075
142negative regulation of translation, ncRNA-mediated (GO:0040033)2.74523676
143regulation of translation, ncRNA-mediated (GO:0045974)2.74523676
144negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.74523676
145somatic diversification of immunoglobulins (GO:0016445)2.72732026

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.76525109
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.24525516
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.22750963
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.03987330
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.56656578
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.71530831
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41427977
8IRF1_19129219_ChIP-ChIP_H3396_Human2.32421110
9* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.19945473
10* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12435617
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.02456870
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.00731023
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse16.9510147
14* SOX2_16153702_ChIP-ChIP_HESCs_Human1.90530753
15CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.88209548
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86982111
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86364408
18SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.70288887
19* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67635458
20MYC_18555785_ChIP-Seq_MESCs_Mouse1.65112844
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55126099
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.53854888
23MYC_19030024_ChIP-ChIP_MESCs_Mouse1.50978423
24ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47504448
25* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44549459
26AR_21909140_ChIP-Seq_LNCAP_Human1.41946629
27* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39388396
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.38083924
29ELK1_19687146_ChIP-ChIP_HELA_Human1.36993758
30ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35580181
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35304127
32HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34611801
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33853285
34SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33801605
35KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.32825188
36VDR_23849224_ChIP-Seq_CD4+_Human1.32139481
37* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31378399
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30471849
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26073471
40EWS_26573619_Chip-Seq_HEK293_Human1.25111052
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24991363
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.23501212
43ZNF274_21170338_ChIP-Seq_K562_Hela1.22019505
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20314428
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18379643
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.17722126
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12288033
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07606398
49* NANOG_16153702_ChIP-ChIP_HESCs_Human1.07562133
50GATA1_22025678_ChIP-Seq_K562_Human1.07539222
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06594300
52KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05282293
53IGF1R_20145208_ChIP-Seq_DFB_Human1.05159423
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03819881
55VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01619956
56STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97351057
57* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.96237749
58SALL4_22934838_ChIP-ChIP_CD34+_Human0.95500889
59POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93973320
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93640644
61TP63_19390658_ChIP-ChIP_HaCaT_Human0.93496439
62* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.91964887
63* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.89617038
64FOXP3_21729870_ChIP-Seq_TREG_Human0.89251204
65FUS_26573619_Chip-Seq_HEK293_Human0.87044079
66KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.84847366
67XRN2_22483619_ChIP-Seq_HELA_Human0.82981332
68TAF15_26573619_Chip-Seq_HEK293_Human0.82693089
69MYC_18358816_ChIP-ChIP_MESCs_Mouse0.82535939
70BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82335339
71ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81965015
72CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81027655
73SOX9_26525672_Chip-Seq_HEART_Mouse0.80268548
74CREB1_15753290_ChIP-ChIP_HEK293T_Human0.80265031
75STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80167234
76* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.78578099
77MYC_22102868_ChIP-Seq_BL_Human0.77826152
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.77403907
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.75703479
80ETS1_22383799_ChIP-Seq_G1ME_Mouse0.75520499
81PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75168804
82THAP11_20581084_ChIP-Seq_MESCs_Mouse0.74898801
83ZFX_18555785_ChIP-Seq_MESCs_Mouse0.74898457
84RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.74131207
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.74097200
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.73272549
87NANOG_18555785_ChIP-Seq_MESCs_Mouse0.72806869
88* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.72504187
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.70995156
90ETS1_20019798_ChIP-Seq_JURKAT_Human0.70446428
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70044296
92SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.69744045
93TDRD3_21172665_ChIP-Seq_MCF-7_Human0.69066053
94PKCTHETA_26484144_Chip-Seq_BREAST_Human0.68267685
95AR_21572438_ChIP-Seq_LNCaP_Human0.67292432
96ELF1_17652178_ChIP-ChIP_JURKAT_Human0.66597832
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.65673690
98HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.65648659
99MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.64846054
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.64415422
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.63703021
102EST1_17652178_ChIP-ChIP_JURKAT_Human0.63295994
103ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.61816605
104GATA1_19941826_ChIP-Seq_K562_Human0.61269715
105GBX2_23144817_ChIP-Seq_PC3_Human0.60104949
106* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.58229319
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.56801285
108PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.56143756
109TTF2_22483619_ChIP-Seq_HELA_Human0.56069101
110VDR_21846776_ChIP-Seq_THP-1_Human0.55981855
111NANOG_21062744_ChIP-ChIP_HESCs_Human0.54984235
112P300_19829295_ChIP-Seq_ESCs_Human0.54743539
113CIITA_25753668_ChIP-Seq_RAJI_Human0.54557769
114MYC_18940864_ChIP-ChIP_HL60_Human0.54317906
115PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.54275305
116* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.54154249
117GABP_17652178_ChIP-ChIP_JURKAT_Human0.53867551
118TFEB_21752829_ChIP-Seq_HELA_Human0.53445363
119SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.53003752
120DCP1A_22483619_ChIP-Seq_HELA_Human0.52800570
121FLI1_27457419_Chip-Seq_LIVER_Mouse0.51343433
122JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.51218778
123EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.51020729
124E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.49521848
125STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.49024594
126VDR_22108803_ChIP-Seq_LS180_Human0.48990855

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.43165665
2MP0010307_abnormal_tumor_latency4.08142112
3MP0003111_abnormal_nucleus_morphology3.79330622
4MP0003077_abnormal_cell_cycle3.45887084
5MP0003693_abnormal_embryo_hatching3.23036359
6MP0002877_abnormal_melanocyte_morpholog3.20461588
7MP0010352_gastrointestinal_tract_polyps3.09401236
8MP0000569_abnormal_digit_pigmentation2.96943099
9MP0004957_abnormal_blastocyst_morpholog2.76064079
10MP0003656_abnormal_erythrocyte_physiolo2.72006364
11MP0008057_abnormal_DNA_replication2.59658521
12MP0004147_increased_porphyrin_level2.54305088
13MP0002254_reproductive_system_inflammat2.52380937
14MP0010234_abnormal_vibrissa_follicle2.41602299
15MP0008007_abnormal_cellular_replicative2.40398894
16MP0003705_abnormal_hypodermis_morpholog2.39748303
17MP0008058_abnormal_DNA_repair2.37009740
18MP0003941_abnormal_skin_development2.25686170
19MP0005645_abnormal_hypothalamus_physiol2.13867523
20MP0000350_abnormal_cell_proliferation2.12915142
21MP0008932_abnormal_embryonic_tissue2.10998666
22MP0005076_abnormal_cell_differentiation2.05077142
23MP0001730_embryonic_growth_arrest1.95319729
24MP0002009_preneoplasia1.92722640
25MP0003718_maternal_effect1.89287168
26MP0004808_abnormal_hematopoietic_stem1.87332181
27MP0006054_spinal_hemorrhage1.82789983
28MP0003123_paternal_imprinting1.82281737
29MP0003136_yellow_coat_color1.81788237
30MP0003121_genomic_imprinting1.81022449
31MP0008877_abnormal_DNA_methylation1.76744818
32MP0001986_abnormal_taste_sensitivity1.76048871
33MP0004197_abnormal_fetal_growth/weight/1.75203542
34MP0006292_abnormal_olfactory_placode1.73598785
35MP0002938_white_spotting1.70873282
36MP0005253_abnormal_eye_physiology1.70199190
37MP0009697_abnormal_copulation1.65690893
38MP0001697_abnormal_embryo_size1.54425455
39MP0002638_abnormal_pupillary_reflex1.53919524
40MP0002166_altered_tumor_susceptibility1.51815496
41MP0002086_abnormal_extraembryonic_tissu1.50245022
42MP0002084_abnormal_developmental_patter1.50128807
43MP0003937_abnormal_limbs/digits/tail_de1.45807126
44MP0005623_abnormal_meninges_morphology1.44359789
45MP0002751_abnormal_autonomic_nervous1.43701074
46MP0005380_embryogenesis_phenotype1.43616350
47MP0001672_abnormal_embryogenesis/_devel1.43616350
48MP0002080_prenatal_lethality1.40412224
49MP0002085_abnormal_embryonic_tissue1.39212728
50MP0003890_abnormal_embryonic-extraembry1.38736102
51MP0001293_anophthalmia1.38064090
52MP0002019_abnormal_tumor_incidence1.38012668
53MP0001529_abnormal_vocalization1.37033323
54MP0000490_abnormal_crypts_of1.35698520
55MP0003300_gastrointestinal_ulcer1.35462383
56MP0006072_abnormal_retinal_apoptosis1.35377297
57MP0008438_abnormal_cutaneous_collagen1.34675609
58MP0002160_abnormal_reproductive_system1.33351941
59MP0002102_abnormal_ear_morphology1.32419937
60MP0006035_abnormal_mitochondrial_morpho1.31687169
61MP0002006_tumorigenesis1.30975442
62MP0003786_premature_aging1.25681731
63MP0005171_absent_coat_pigmentation1.25122380
64MP0000631_abnormal_neuroendocrine_gland1.24871461
65MP0003984_embryonic_growth_retardation1.24323195
66MP0002396_abnormal_hematopoietic_system1.23106420
67MP0002088_abnormal_embryonic_growth/wei1.22699023
68MP0002095_abnormal_skin_pigmentation1.21023649
69MP0000372_irregular_coat_pigmentation1.20812401
70MP0002092_abnormal_eye_morphology1.20412395
71MP0000733_abnormal_muscle_development1.20104100
72MP0000703_abnormal_thymus_morphology1.19100391
73MP0003787_abnormal_imprinting1.18672524
74MP0002163_abnormal_gland_morphology1.18485654
75MP0000313_abnormal_cell_death1.18234502
76MP0002697_abnormal_eye_size1.13513708
77MP0000647_abnormal_sebaceous_gland1.09572200
78MP0000537_abnormal_urethra_morphology1.09149404
79MP0009703_decreased_birth_body1.06295055
80MP0002111_abnormal_tail_morphology1.05426190
81MP0001929_abnormal_gametogenesis1.04501027
82MP0002210_abnormal_sex_determination1.04178805
83MP0001919_abnormal_reproductive_system1.03825478
84MP0005671_abnormal_response_to1.02892155
85MP0001661_extended_life_span1.02584309
86MP0002398_abnormal_bone_marrow0.99543522
87MP0002233_abnormal_nose_morphology0.98761717
88MP0005408_hypopigmentation0.98327482
89MP0000358_abnormal_cell_content/0.97178825
90MP0009046_muscle_twitch0.96995695
91MP0005551_abnormal_eye_electrophysiolog0.96581418
92MP0009053_abnormal_anal_canal0.96425832
93MP0008770_decreased_survivor_rate0.95728540
94MP0000383_abnormal_hair_follicle0.95382975
95MP0010030_abnormal_orbit_morphology0.94779611
96MP0002722_abnormal_immune_system0.94267044
97MP0003763_abnormal_thymus_physiology0.94073161
98MP0002736_abnormal_nociception_after0.93797109
99MP0005389_reproductive_system_phenotype0.93437721
100MP0005075_abnormal_melanosome_morpholog0.93273445
101MP0003806_abnormal_nucleotide_metabolis0.91773130
102MP0010678_abnormal_skin_adnexa0.90892574
103MP0000371_diluted_coat_color0.90628563
104MP0001145_abnormal_male_reproductive0.90362939
105MP0002075_abnormal_coat/hair_pigmentati0.89505346
106MP0003119_abnormal_digestive_system0.88941557
107MP0004742_abnormal_vestibular_system0.88317435
108MP0001186_pigmentation_phenotype0.86078396
109MP0001915_intracranial_hemorrhage0.85912734
110MP0000428_abnormal_craniofacial_morphol0.85800121
111MP0005187_abnormal_penis_morphology0.83818708
112MP0003567_abnormal_fetal_cardiomyocyte0.83775518
113MP0003315_abnormal_perineum_morphology0.82961499
114MP0001286_abnormal_eye_development0.82296370
115MP0005621_abnormal_cell_physiology0.82086326
116MP0000653_abnormal_sex_gland0.82034390
117MP0009672_abnormal_birth_weight0.81175734
118MP0002138_abnormal_hepatobiliary_system0.80978422
119MP0000685_abnormal_immune_system0.80328373
120MP0005384_cellular_phenotype0.79196602
121MP0004381_abnormal_hair_follicle0.78409341
122MP0003453_abnormal_keratinocyte_physiol0.78237268
123MP0000689_abnormal_spleen_morphology0.78194393
124MP0002925_abnormal_cardiovascular_devel0.78018558
125MP0005220_abnormal_exocrine_pancreas0.77496290
126MP0008995_early_reproductive_senescence0.75718567
127MP0005391_vision/eye_phenotype0.75664988
128MP0005083_abnormal_biliary_tract0.75535035
129MP0005174_abnormal_tail_pigmentation0.74824647
130MP0003566_abnormal_cell_adhesion0.74623195
131MP0003698_abnormal_male_reproductive0.72842137
132MP0000432_abnormal_head_morphology0.72546486
133MP0001299_abnormal_eye_distance/0.70227594
134MP0002429_abnormal_blood_cell0.67306484
135MP0005501_abnormal_skin_physiology0.66684802
136MP0000858_altered_metastatic_potential0.66070605
137MP0004233_abnormal_muscle_weight0.65362439
138MP0005023_abnormal_wound_healing0.64644619
139MP0004185_abnormal_adipocyte_glucose0.63522021
140MP0000015_abnormal_ear_pigmentation0.63334700
141MP0000427_abnormal_hair_cycle0.61499209
142MP0001849_ear_inflammation0.61426788
143MP0003091_abnormal_cell_migration0.61392715
144MP0004947_skin_inflammation0.58664000
145MP0004264_abnormal_extraembryonic_tissu0.58659009
146MP0003861_abnormal_nervous_system0.57867728
147MP0001191_abnormal_skin_condition0.57107449
148MP0003935_abnormal_craniofacial_develop0.56050549

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)5.06784498
2Poikilocytosis (HP:0004447)4.74377318
3Cutaneous melanoma (HP:0012056)4.67245959
4IgM deficiency (HP:0002850)3.95238689
5IgA deficiency (HP:0002720)3.65479783
6Chromsome breakage (HP:0040012)3.46317514
7Abnormality of the heme biosynthetic pathway (HP:0010472)3.36402051
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.29313921
9Abnormality of chromosome stability (HP:0003220)3.22590483
10Acanthocytosis (HP:0001927)3.06497429
11Volvulus (HP:0002580)3.02093991
12Short 4th metacarpal (HP:0010044)2.94216253
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.94216253
14Birth length less than 3rd percentile (HP:0003561)2.92691549
15Reticulocytopenia (HP:0001896)2.84551110
16Nephroblastoma (Wilms tumor) (HP:0002667)2.79880623
17Clubbing of toes (HP:0100760)2.78932713
18Lipid accumulation in hepatocytes (HP:0006561)2.75100673
19Hypopigmentation of the fundus (HP:0007894)2.74668293
20Carpal bone hypoplasia (HP:0001498)2.70630058
21Increased hepatocellular lipid droplets (HP:0006565)2.68258439
22Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.67860039
2311 pairs of ribs (HP:0000878)2.66220899
24Embryonal renal neoplasm (HP:0011794)2.65800974
25Abnormality of the astrocytes (HP:0100707)2.64825606
26Astrocytoma (HP:0009592)2.64825606
27Abnormality of reticulocytes (HP:0004312)2.56162789
28Impulsivity (HP:0100710)2.52365403
29Colon cancer (HP:0003003)2.49008017
30Glioma (HP:0009733)2.48668664
31Selective tooth agenesis (HP:0001592)2.48141301
32Freckling (HP:0001480)2.47639417
33Biliary tract neoplasm (HP:0100574)2.45815454
34Squamous cell carcinoma (HP:0002860)2.43769248
35Rhabdomyosarcoma (HP:0002859)2.40231691
36Reticulocytosis (HP:0001923)2.40194358
37Abnormal lung lobation (HP:0002101)2.39933477
38Abnormality of the labia minora (HP:0012880)2.37468621
39Cafe-au-lait spot (HP:0000957)2.35075252
40Missing ribs (HP:0000921)2.34450100
41Medulloblastoma (HP:0002885)2.34094968
42Sandal gap (HP:0001852)2.32386790
43High pitched voice (HP:0001620)2.31237749
44Deviation of the thumb (HP:0009603)2.29891539
45Prominent nose (HP:0000448)2.28019612
46Subacute progressive viral hepatitis (HP:0006572)2.27885050
47Intestinal atresia (HP:0011100)2.27697865
48Ependymoma (HP:0002888)2.27365196
49Basal cell carcinoma (HP:0002671)2.24134523
50Abnormality of DNA repair (HP:0003254)2.23784797
51Absent radius (HP:0003974)2.22854948
52Triphalangeal thumb (HP:0001199)2.21358150
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.21102780
54Absent thumb (HP:0009777)2.18946952
55Abnormality of the calcaneus (HP:0008364)2.17123633
56Increased nuchal translucency (HP:0010880)2.16366752
57Sloping forehead (HP:0000340)2.15599170
58Prostate neoplasm (HP:0100787)2.15263350
59Duodenal stenosis (HP:0100867)2.15074906
60Small intestinal stenosis (HP:0012848)2.15074906
61Septo-optic dysplasia (HP:0100842)2.14892618
62Entropion (HP:0000621)2.13287692
63Ulnar bowing (HP:0003031)2.13145050
64Absent frontal sinuses (HP:0002688)2.12351000
65Dry hair (HP:0011359)2.10890848
66Aplasia involving forearm bones (HP:0009822)2.09598738
67Absent forearm bone (HP:0003953)2.09598738
68Bilateral microphthalmos (HP:0007633)2.09349498
69Abnormality of oral frenula (HP:0000190)2.09031608
70Hypochromic anemia (HP:0001931)2.08890841
71Gastrointestinal carcinoma (HP:0002672)2.08162447
72Malignant gastrointestinal tract tumors (HP:0006749)2.08162447
73Cortical dysplasia (HP:0002539)2.07822944
74Esophageal atresia (HP:0002032)2.07112363
75Myelodysplasia (HP:0002863)2.06496982
76Abnormal number of erythroid precursors (HP:0012131)2.05811873
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04826120
78Abnormality of alanine metabolism (HP:0010916)2.04826120
79Hyperalaninemia (HP:0003348)2.04826120
80Recurrent sinusitis (HP:0011108)2.03777561
81Short thumb (HP:0009778)2.03291082
82Proximal placement of thumb (HP:0009623)2.01275708
83Abnormality of the 4th metacarpal (HP:0010012)1.99507618
84Chronic hepatic failure (HP:0100626)1.99380728
85Abnormality of cells of the erythroid lineage (HP:0012130)1.98756591
86Neoplasm of the oral cavity (HP:0100649)1.97953914
87Dyschromatopsia (HP:0007641)1.97924927
88Thyroiditis (HP:0100646)1.97511828
89Heterotopia (HP:0002282)1.97382779
90T lymphocytopenia (HP:0005403)1.97192953
91Neoplasm of the adrenal cortex (HP:0100641)1.97187254
92Hypoplasia of the pons (HP:0012110)1.96575945
93Deep philtrum (HP:0002002)1.96512030
94Hematochezia (HP:0002573)1.96042035
95Abnormality of the pons (HP:0007361)1.95269628
96Meckel diverticulum (HP:0002245)1.94238372
97Agnosia (HP:0010524)1.92792522
98Neoplasm of the pancreas (HP:0002894)1.92322894
99Neoplasm of the colon (HP:0100273)1.91913366
100Horseshoe kidney (HP:0000085)1.91560251
101IgG deficiency (HP:0004315)1.91343624
102Atresia of the external auditory canal (HP:0000413)1.90818383
103Aplasia/Hypoplasia of the sternum (HP:0006714)1.90234300
104Increased density of long bones (HP:0006392)1.90071239
105Bicornuate uterus (HP:0000813)1.89415503
106Patellar aplasia (HP:0006443)1.89087286
107Truncal obesity (HP:0001956)1.88966299
108Stenosis of the external auditory canal (HP:0000402)1.88768799
109Radial bowing (HP:0002986)1.87166135
110Mesomelia (HP:0003027)1.86042094
111Spastic diplegia (HP:0001264)1.85527735
112Leiomyosarcoma (HP:0100243)1.84802337
113Uterine leiomyosarcoma (HP:0002891)1.84802337
114Attenuation of retinal blood vessels (HP:0007843)1.84261572
115Colitis (HP:0002583)1.82427706
116Abnormality of the ileum (HP:0001549)1.81928006
117Abnormality of the parietal bone (HP:0002696)1.81777047
118Abnormality of the duodenum (HP:0002246)1.81431930
119Cleft eyelid (HP:0000625)1.79769753
120Lymphopenia (HP:0001888)1.79420027
121Abnormality of the phalanges of the 2nd finger (HP:0009541)1.79384448
122Insomnia (HP:0100785)1.78989009
123Breast carcinoma (HP:0003002)1.78465317
124Arteriovenous malformation (HP:0100026)1.78112951
125Ovarian neoplasm (HP:0100615)1.78085372
126Verrucae (HP:0200043)1.77438048
127Papilloma (HP:0012740)1.77438048
128Ankyloglossia (HP:0010296)1.77420930
129Pelvic girdle muscle weakness (HP:0003749)1.76725834
130Broad face (HP:0000283)1.76647417
131Intestinal polyposis (HP:0200008)1.76519506
132Abnormality of T cell number (HP:0011839)1.76124643
133Duplicated collecting system (HP:0000081)1.74186421
134Partial agenesis of the corpus callosum (HP:0001338)1.74039240
135Aplasia/Hypoplasia of the patella (HP:0006498)1.73619602
136Ankle contracture (HP:0006466)1.73514313
137Abnormality of cells of the lymphoid lineage (HP:0012140)1.73442200
138Transitional cell carcinoma of the bladder (HP:0006740)1.73347844
139Stillbirth (HP:0003826)1.73233134
140Ectopic kidney (HP:0000086)1.73147285
141Neoplasm of striated muscle (HP:0009728)1.72782341
142Microtia (HP:0008551)1.71769647
143Cutis marmorata (HP:0000965)1.71237715
144Abnormality of the fingertips (HP:0001211)1.71065049
145Abnormality of the preputium (HP:0100587)1.70736919
146Wrist flexion contracture (HP:0001239)1.69921229
147Cholelithiasis (HP:0001081)1.69693240
148Cerebellar dysplasia (HP:0007033)1.69675574
149Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.69410274
150Long eyelashes (HP:0000527)1.68657829
151Bladder neoplasm (HP:0009725)1.68277012
152Bladder carcinoma (HP:0002862)1.68277012
153Abnormality of the carotid arteries (HP:0005344)1.68232426
154Lissencephaly (HP:0001339)1.67601497
155Abnormality of the septum pellucidum (HP:0007375)1.67564827
156Tracheoesophageal fistula (HP:0002575)1.65373276
157Optic nerve hypoplasia (HP:0000609)1.64617800
158Thyroid carcinoma (HP:0002890)1.64320269
159Abnormality of the renal collecting system (HP:0004742)1.64267283
160Cellular immunodeficiency (HP:0005374)1.63197705
161Chorioretinal atrophy (HP:0000533)1.61466922
162Clitoromegaly (HP:0000057)1.57589437
163Gastrointestinal atresia (HP:0002589)1.56158233
164Congenital stationary night blindness (HP:0007642)1.56122391

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.62403748
2ZAK6.71363728
3VRK13.63445790
4STK43.08164079
5CDC72.95200010
6RPS6KA52.85433176
7CDK91.94160376
8EEF2K1.92677658
9SCYL21.91301043
10TAF11.88484356
11WEE11.69128723
12NEK21.66682432
13AURKB1.64067596
14PIM11.63858663
15SRPK11.60745105
16MAP3K81.54635652
17CHEK21.49565962
18MAP3K101.49229348
19DAPK31.49175562
20CDK121.44552032
21BUB11.42589673
22PKN21.38855629
23TTN1.38079077
24PASK1.35587536
25EIF2AK11.25313833
26EPHA21.23736678
27FRK1.23106278
28NUAK11.18029662
29VRK21.17791462
30RPS6KB21.17246975
31TSSK61.16258616
32MAP3K41.13998018
33DYRK31.12932783
34TTK1.08122719
35PKN11.06379021
36FLT31.00530044
37ATR0.97869364
38MAP2K70.93466203
39PLK10.88778888
40AURKA0.86736876
41PLK30.86546465
42WNK30.86268078
43STK100.84254172
44NEK10.83945034
45MELK0.82816806
46BMPR1B0.78067306
47BRSK20.77326533
48EIF2AK30.77301401
49ACVR1B0.77055177
50CDK60.75824719
51LATS10.73817407
52DYRK20.72116842
53NME20.69452522
54STK30.68530921
55MKNK20.67120563
56GRK60.66052295
57CHEK10.64656157
58CSNK1G10.63533563
59DYRK1B0.63445575
60ATM0.62696495
61ADRBK20.61920571
62CAMK1D0.60575181
63CDK40.60257869
64FGFR20.58297611
65TGFBR10.57638395
66CSNK1G30.57632669
67MST40.55556712
68SMG10.54331143
69CSNK1A1L0.54026121
70EIF2AK20.52600624
71PRKAA10.50714634
72CDK20.49749137
73MET0.49716882
74NLK0.49450697
75BTK0.45105681
76PBK0.44744825
77AKT20.44525660
78RPS6KA40.43972064
79LRRK20.43035548
80CCNB10.40606894
81CDK10.40468508
82CSNK1G20.38869961
83BRD40.36135579
84CDK70.35354131
85OXSR10.35084774
86TRPM70.34431786
87CSNK1D0.33623658
88BRSK10.32728970
89IRAK40.32711225
90ROCK10.31237423
91CASK0.30750268
92STK38L0.30448500
93CDK190.29783024
94PAK20.28442915
95MTOR0.28325613
96KSR10.28047728
97MUSK0.26748746
98RPS6KB10.26631986
99PRKDC0.26471227
100GRK10.26138756
101MARK30.25871386
102MAP4K20.25537343
103PRKCQ0.24331219
104PDGFRA0.23910388
105BMX0.23177644
106JAK20.22771200
107STK160.22515369
108STK240.21931378
109PAK10.21784528
110PLK40.21354598
111ERBB30.20832482
112CAMK40.20283391
113NEK90.20044174
114SYK0.20044025
115TEC0.19851117
116MKNK10.19704089
117MAP2K40.19643683
118MAPKAPK50.19542044
119TESK20.18999219
120INSRR0.18584976
121AKT10.17816886
122MAPK140.17401850
123FGFR30.17230442
124ALK0.15575315
125HIPK20.15341987
126ILK0.15188696
127PTK60.14441304
128RPS6KC10.14381397
129RPS6KL10.14381397
130LYN0.14143311
131RAF10.13804788
132IKBKE0.13187262
133PIK3CG0.12958420
134SGK10.11742843
135BCR0.11575367
136CHUK0.11090917
137BRAF0.10902223
138EPHA40.10411208
139PRKCB0.10243318
140MAP2K20.09514261
141DYRK1A0.09500950
142IKBKB0.09397019
143TRIB30.09331856
144SGK30.08331705
145CSNK2A20.07906397

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.58163474
2* Viral carcinogenesis_Homo sapiens_hsa052033.51388511
3DNA replication_Homo sapiens_hsa030302.53554441
4Mismatch repair_Homo sapiens_hsa034302.31835303
5Cell cycle_Homo sapiens_hsa041102.03271468
6* Systemic lupus erythematosus_Homo sapiens_hsa0532211.4261736
7One carbon pool by folate_Homo sapiens_hsa006701.93572326
8Transcriptional misregulation in cancer_Homo sapiens_hsa052021.81540843
9Non-homologous end-joining_Homo sapiens_hsa034501.80014444
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58283204
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54480153
12Nucleotide excision repair_Homo sapiens_hsa034201.49609237
13RNA transport_Homo sapiens_hsa030131.45682905
14Fanconi anemia pathway_Homo sapiens_hsa034601.36738678
15Base excision repair_Homo sapiens_hsa034101.29493517
16p53 signaling pathway_Homo sapiens_hsa041151.27530351
17Homologous recombination_Homo sapiens_hsa034401.20807529
18Spliceosome_Homo sapiens_hsa030401.17345983
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.08465088
20Ribosome_Homo sapiens_hsa030101.02605944
21MicroRNAs in cancer_Homo sapiens_hsa052061.01399978
22mRNA surveillance pathway_Homo sapiens_hsa030151.00390812
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.00165807
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84631156
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84125015
26Small cell lung cancer_Homo sapiens_hsa052220.81936005
27Chronic myeloid leukemia_Homo sapiens_hsa052200.81688703
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81357283
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76668728
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74288856
31Asthma_Homo sapiens_hsa053100.72071257
32RNA degradation_Homo sapiens_hsa030180.69054179
33Selenocompound metabolism_Homo sapiens_hsa004500.66982899
34HTLV-I infection_Homo sapiens_hsa051660.65345688
35Non-small cell lung cancer_Homo sapiens_hsa052230.64275336
36Bladder cancer_Homo sapiens_hsa052190.64064454
37Apoptosis_Homo sapiens_hsa042100.61376554
38Pyrimidine metabolism_Homo sapiens_hsa002400.61194483
39Steroid biosynthesis_Homo sapiens_hsa001000.59707133
40Allograft rejection_Homo sapiens_hsa053300.58697808
41Herpes simplex infection_Homo sapiens_hsa051680.57185832
42Autoimmune thyroid disease_Homo sapiens_hsa053200.54884846
43Oocyte meiosis_Homo sapiens_hsa041140.53720654
44Oxidative phosphorylation_Homo sapiens_hsa001900.53018680
45Epstein-Barr virus infection_Homo sapiens_hsa051690.52322806
46Pancreatic cancer_Homo sapiens_hsa052120.51798512
47Parkinsons disease_Homo sapiens_hsa050120.51113566
48Antigen processing and presentation_Homo sapiens_hsa046120.50067151
49Hepatitis B_Homo sapiens_hsa051610.49510613
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48606186
51Colorectal cancer_Homo sapiens_hsa052100.47661432
52mTOR signaling pathway_Homo sapiens_hsa041500.46366973
53RNA polymerase_Homo sapiens_hsa030200.46131409
54Prostate cancer_Homo sapiens_hsa052150.45950516
55FoxO signaling pathway_Homo sapiens_hsa040680.45573891
56Melanoma_Homo sapiens_hsa052180.43051135
57TGF-beta signaling pathway_Homo sapiens_hsa043500.42311819
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41999431
59Glioma_Homo sapiens_hsa052140.41122658
60Huntingtons disease_Homo sapiens_hsa050160.41048061
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.40103880
62Butanoate metabolism_Homo sapiens_hsa006500.39886513
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.39344052
64Graft-versus-host disease_Homo sapiens_hsa053320.38714998
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36765404
66Phototransduction_Homo sapiens_hsa047440.36740533
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36529917
68Hedgehog signaling pathway_Homo sapiens_hsa043400.35988915
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.35700489
70Taste transduction_Homo sapiens_hsa047420.34777139
71Basal transcription factors_Homo sapiens_hsa030220.34354503
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34339536
73Proteoglycans in cancer_Homo sapiens_hsa052050.34148800
74Type I diabetes mellitus_Homo sapiens_hsa049400.33860746
75Measles_Homo sapiens_hsa051620.32997852
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32278591
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.32176560
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31074659
79Endometrial cancer_Homo sapiens_hsa052130.30819472
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30493662
81Hippo signaling pathway_Homo sapiens_hsa043900.29997934
82B cell receptor signaling pathway_Homo sapiens_hsa046620.29338435
83Legionellosis_Homo sapiens_hsa051340.28908580
84Thyroid cancer_Homo sapiens_hsa052160.28254845
85Adherens junction_Homo sapiens_hsa045200.28238906
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27669200
87Focal adhesion_Homo sapiens_hsa045100.25231625
88Tight junction_Homo sapiens_hsa045300.24895890
89Hematopoietic cell lineage_Homo sapiens_hsa046400.24503788
90Nitrogen metabolism_Homo sapiens_hsa009100.24227480
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23328080
92Tryptophan metabolism_Homo sapiens_hsa003800.22880237
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.22607661
94Purine metabolism_Homo sapiens_hsa002300.22505434
95Pathways in cancer_Homo sapiens_hsa052000.21702461
96Lysine degradation_Homo sapiens_hsa003100.21553051
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20019105
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.19253266
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.19228067
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19055302
101Malaria_Homo sapiens_hsa051440.18876851
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17901590
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16483257
104Alzheimers disease_Homo sapiens_hsa050100.16480077
105Viral myocarditis_Homo sapiens_hsa054160.16318050
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.16241551
107Caffeine metabolism_Homo sapiens_hsa002320.16139137
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.15846905
109TNF signaling pathway_Homo sapiens_hsa046680.15572931
110Toxoplasmosis_Homo sapiens_hsa051450.15463620
111Influenza A_Homo sapiens_hsa051640.15281650
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15243240
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15102993
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14859911
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14821190
116Inositol phosphate metabolism_Homo sapiens_hsa005620.14390562
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.14282387
118HIF-1 signaling pathway_Homo sapiens_hsa040660.14086964
119Wnt signaling pathway_Homo sapiens_hsa043100.13656202
120AMPK signaling pathway_Homo sapiens_hsa041520.13608993
121Renin-angiotensin system_Homo sapiens_hsa046140.13072413
122Propanoate metabolism_Homo sapiens_hsa006400.13052182
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12831081
124Vitamin B6 metabolism_Homo sapiens_hsa007500.12286822
125Platelet activation_Homo sapiens_hsa046110.11654954
126Proteasome_Homo sapiens_hsa030500.11565884
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.10604303
128Sulfur relay system_Homo sapiens_hsa041220.10320383
129Renal cell carcinoma_Homo sapiens_hsa052110.09925951
130Type II diabetes mellitus_Homo sapiens_hsa049300.09224029
131Biosynthesis of amino acids_Homo sapiens_hsa012300.09098364
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09050969
133Basal cell carcinoma_Homo sapiens_hsa052170.08183079
134Metabolic pathways_Homo sapiens_hsa011000.08025254
135ECM-receptor interaction_Homo sapiens_hsa045120.07853952
136Pyruvate metabolism_Homo sapiens_hsa006200.07445726
137RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.07008151
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06694889
139Osteoclast differentiation_Homo sapiens_hsa043800.06574962
140Primary immunodeficiency_Homo sapiens_hsa053400.06418220
141Nicotine addiction_Homo sapiens_hsa050330.05997776
142Neurotrophin signaling pathway_Homo sapiens_hsa047220.05877060
143Sulfur metabolism_Homo sapiens_hsa009200.05864346
144Regulation of actin cytoskeleton_Homo sapiens_hsa048100.05724809
145Prolactin signaling pathway_Homo sapiens_hsa049170.05534000
146Olfactory transduction_Homo sapiens_hsa047400.04262624
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.03466412
148Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040-0.0125424
149Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0103471
150N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0053386
151Steroid hormone biosynthesis_Homo sapiens_hsa00140-0.0009679

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