HIST1H2BF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. The protein has antibacterial and antifungal antimicrobial activity. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome organization (GO:0034723)8.80005043
2DNA replication-dependent nucleosome assembly (GO:0006335)8.80005043
3chromatin assembly (GO:0031497)8.21774915
4regulation of histone H3-K9 methylation (GO:0051570)6.87656167
5nucleosome assembly (GO:0006334)6.82437134
6nuclear pore complex assembly (GO:0051292)6.24791592
7nuclear pore organization (GO:0006999)6.07127662
8antibacterial humoral response (GO:0019731)5.97087078
9nucleosome organization (GO:0034728)5.91021524
10protein-DNA complex assembly (GO:0065004)5.81339826
11chromatin assembly or disassembly (GO:0006333)5.79046644
12antimicrobial humoral response (GO:0019730)5.56274180
13DNA unwinding involved in DNA replication (GO:0006268)5.51757062
14protein localization to kinetochore (GO:0034501)5.51422880
15innate immune response in mucosa (GO:0002227)5.45118456
16protein-DNA complex subunit organization (GO:0071824)5.20393559
17mitotic chromosome condensation (GO:0007076)5.12648995
18sister chromatid segregation (GO:0000819)5.06880788
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.79211209
20folic acid-containing compound biosynthetic process (GO:0009396)4.75642842
21V(D)J recombination (GO:0033151)4.71641969
22pore complex assembly (GO:0046931)4.70323547
23protein localization to chromosome, centromeric region (GO:0071459)4.67276731
24mitotic sister chromatid segregation (GO:0000070)4.56011531
25chromatin remodeling at centromere (GO:0031055)4.48717903
26regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.44086197
27CENP-A containing nucleosome assembly (GO:0034080)4.25373174
28kinetochore organization (GO:0051383)4.24109957
29DNA replication initiation (GO:0006270)4.21829791
30mitotic nuclear envelope disassembly (GO:0007077)4.15181541
31mucosal immune response (GO:0002385)4.15157593
32defense response to Gram-positive bacterium (GO:0050830)4.10667512
33regulation of centriole replication (GO:0046599)4.08688866
34DNA duplex unwinding (GO:0032508)4.04215160
35positive regulation of chromosome segregation (GO:0051984)4.03978485
36positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.03648175
37positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.03648175
38positive regulation of mitotic sister chromatid separation (GO:1901970)4.03648175
39DNA geometric change (GO:0032392)4.02539900
40regulation of gene silencing (GO:0060968)3.96706898
41membrane disassembly (GO:0030397)3.94971163
42nuclear envelope disassembly (GO:0051081)3.94971163
43organ or tissue specific immune response (GO:0002251)3.91603051
44IMP biosynthetic process (GO:0006188)3.84336933
45protein K6-linked ubiquitination (GO:0085020)3.82828606
46regulation of megakaryocyte differentiation (GO:0045652)3.80869400
47negative regulation of histone methylation (GO:0031061)3.79731042
48DNA strand elongation involved in DNA replication (GO:0006271)3.78355657
49DNA replication-independent nucleosome assembly (GO:0006336)3.76092457
50DNA replication-independent nucleosome organization (GO:0034724)3.76092457
51mitotic sister chromatid cohesion (GO:0007064)3.74517504
52regulation of centrosome cycle (GO:0046605)3.72563508
53regulation of DNA endoreduplication (GO:0032875)3.70894116
54heterochromatin organization (GO:0070828)3.67842630
55regulation of translational fidelity (GO:0006450)3.67565415
56regulation of sister chromatid cohesion (GO:0007063)3.63803041
57regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.60632258
58mitotic recombination (GO:0006312)3.60415597
59viral transcription (GO:0019083)3.58085853
60histone exchange (GO:0043486)3.57116643
61DNA strand elongation (GO:0022616)3.56603049
62translational termination (GO:0006415)3.56269695
63regulation of gene silencing by miRNA (GO:0060964)3.55601464
64regulation of gene silencing by RNA (GO:0060966)3.55601464
65regulation of posttranscriptional gene silencing (GO:0060147)3.55601464
66telomere maintenance via semi-conservative replication (GO:0032201)3.53275421
67attachment of spindle microtubules to kinetochore (GO:0008608)3.52725515
68regulation of spindle organization (GO:0090224)3.51824363
69dosage compensation (GO:0007549)3.50045713
70regulation of centrosome duplication (GO:0010824)3.47338000
71chromosome condensation (GO:0030261)3.46246446
72meiotic chromosome segregation (GO:0045132)3.46181616
73negative regulation of thymocyte apoptotic process (GO:0070244)3.45683961
74regulation of mitotic spindle organization (GO:0060236)3.44963422
75IMP metabolic process (GO:0046040)3.44499776
76ribosomal large subunit biogenesis (GO:0042273)3.42457023
77negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.37235731
78protoporphyrinogen IX metabolic process (GO:0046501)3.35483934
79regulation of chromosome segregation (GO:0051983)3.33247154
80mitotic metaphase plate congression (GO:0007080)3.33056085
81translesion synthesis (GO:0019985)3.32193337
82DNA synthesis involved in DNA repair (GO:0000731)3.31632828
83positive regulation of histone methylation (GO:0031062)3.31516275
84microtubule depolymerization (GO:0007019)3.28960285
85telomere maintenance via recombination (GO:0000722)3.28564846
86DNA replication checkpoint (GO:0000076)3.27637640
87DNA conformation change (GO:0071103)3.26186465
88DNA topological change (GO:0006265)3.25732103
89somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.24873190
90somatic cell DNA recombination (GO:0016444)3.24873190
91regulation of RNA export from nucleus (GO:0046831)3.22262279
92translational elongation (GO:0006414)3.22212849
93protein localization to chromosome (GO:0034502)3.20838732
94telomere organization (GO:0032200)3.20532851
95regulation of mitotic metaphase/anaphase transition (GO:0030071)3.17491583
96metaphase plate congression (GO:0051310)3.16368192
97spindle checkpoint (GO:0031577)3.16345992
98negative regulation of DNA repair (GO:0045738)3.15911139
99ATP-dependent chromatin remodeling (GO:0043044)3.12944733
100ribosomal small subunit assembly (GO:0000028)3.10770909
101kinetochore assembly (GO:0051382)3.10391774
102regulation of helicase activity (GO:0051095)3.09604719
103non-recombinational repair (GO:0000726)3.09561111
104double-strand break repair via nonhomologous end joining (GO:0006303)3.09561111
105regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.08878817
106chromosome segregation (GO:0007059)3.06876399
107nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.06633013
108spindle assembly involved in mitosis (GO:0090307)3.05994939
109telomere maintenance (GO:0000723)3.05491073
110nucleotide-excision repair, DNA gap filling (GO:0006297)3.05052571
111positive regulation of granulocyte differentiation (GO:0030854)3.03976912
112postreplication repair (GO:0006301)3.03282584
113protoporphyrinogen IX biosynthetic process (GO:0006782)3.02768240
114viral mRNA export from host cell nucleus (GO:0046784)3.01530785
115regulation of mitotic sister chromatid separation (GO:0010965)2.96109342
116regulation of mitotic sister chromatid segregation (GO:0033047)2.96109342
117regulation of sister chromatid segregation (GO:0033045)2.96109342
118negative regulation of chromosome segregation (GO:0051985)2.91189094
119somatic diversification of immune receptors (GO:0002200)2.88871805
120telomere maintenance via telomere lengthening (GO:0010833)2.86423494
121maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.81634465
122replicative senescence (GO:0090399)2.77163008
123mitotic spindle assembly checkpoint (GO:0007094)2.75512427
124regulation of DNA damage checkpoint (GO:2000001)2.74416054
125histone lysine demethylation (GO:0070076)2.74219489
126negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.74087486
127negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.74087486
128negative regulation of mitotic sister chromatid segregation (GO:0033048)2.74087486
129negative regulation of mitotic sister chromatid separation (GO:2000816)2.74087486
130negative regulation of sister chromatid segregation (GO:0033046)2.74087486
131histone phosphorylation (GO:0016572)2.74076887
132centrosome duplication (GO:0051298)2.73636586
133spindle assembly checkpoint (GO:0071173)2.73468802

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.43272206
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.52335796
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.26686901
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.98341016
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.47732626
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.03878441
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.52961123
8* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.26880461
9* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18307647
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.10799779
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.08217055
12* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07576443
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse16.2785132
14* SOX2_16153702_ChIP-ChIP_HESCs_Human1.95330199
15* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.94381770
16NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94312480
17* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.77316859
18MYC_19030024_ChIP-ChIP_MESCs_Mouse1.69595828
19SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.69152327
20AR_21909140_ChIP-Seq_LNCAP_Human1.65319512
21IRF1_19129219_ChIP-ChIP_H3396_Human1.64462664
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.60574992
23GATA1_22025678_ChIP-Seq_K562_Human1.60186295
24MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59919058
25* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59532766
26ESR1_15608294_ChIP-ChIP_MCF-7_Human1.59454742
27ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52879701
28* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51570900
29SOX2_18555785_ChIP-Seq_MESCs_Mouse1.50746148
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44141110
31KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.43548787
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42027707
33* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33403158
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33061979
35POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28337529
36* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.27770511
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25839222
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.24423077
39* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24296987
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.22850713
41ELK1_19687146_ChIP-ChIP_HELA_Human1.21718987
42* VDR_23849224_ChIP-Seq_CD4+_Human1.20209365
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15870325
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14553159
45TCF3_18692474_ChIP-Seq_MESCs_Mouse1.14403294
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13343254
47* NANOG_16153702_ChIP-ChIP_HESCs_Human1.12163057
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10127566
49CIITA_25753668_ChIP-Seq_RAJI_Human1.06974091
50* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.06787833
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01567017
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00062599
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99430456
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98727689
55XRN2_22483619_ChIP-Seq_HELA_Human0.97983458
56NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97580638
57MYC_22102868_ChIP-Seq_BL_Human0.95525127
58PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95491217
59PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91992344
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91904301
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.90730215
62ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87920729
63RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87441238
64FOXP3_21729870_ChIP-Seq_TREG_Human0.87404130
65CREB1_15753290_ChIP-ChIP_HEK293T_Human0.85339617
66CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83951144
67KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.83589031
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82316071
69SCL_19346495_ChIP-Seq_HPC-7_Human0.81752781
70MYCN_18555785_ChIP-Seq_MESCs_Mouse0.81106805
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.80211264
72ZFX_18555785_ChIP-Seq_MESCs_Mouse0.79288545
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.79109335
74MAF_26560356_Chip-Seq_TH1_Human0.77988415
75NOTCH1_21737748_ChIP-Seq_TLL_Human0.77300502
76THAP11_20581084_ChIP-Seq_MESCs_Mouse0.77210876
77STAT4_19710469_ChIP-ChIP_TH1__Mouse0.77188186
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.75937235
79YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.74848447
80BRD4_27068464_Chip-Seq_AML-cells_Mouse0.74663954
81EST1_17652178_ChIP-ChIP_JURKAT_Human0.72205698
82PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71820520
83SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.70360956
84NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.70225535
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.69853542
86NANOG_21062744_ChIP-ChIP_HESCs_Human0.69770916
87MYB_26560356_Chip-Seq_TH1_Human0.69610903
88RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.68991692
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.68833953
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.67912296
91SALL4_22934838_ChIP-ChIP_CD34+_Human0.67700544
92ETS1_22383799_ChIP-Seq_G1ME_Mouse0.66090475
93TTF2_22483619_ChIP-Seq_HELA_Human0.63446264
94* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.63412169
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.62967210
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.62746603
97* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.61978257
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.61867723
99SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.60154231
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.60070189
101MYB_26560356_Chip-Seq_TH2_Human0.59796635
102ETS1_20019798_ChIP-Seq_JURKAT_Human0.59367222
103TCF3_18692474_ChIP-Seq_MEFs_Mouse0.58374351
104KDM5A_27292631_Chip-Seq_BREAST_Human0.58328143
105* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.58291464
106MYC_18940864_ChIP-ChIP_HL60_Human0.57814969
107VDR_21846776_ChIP-Seq_THP-1_Human0.57217246
108SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.56782765
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.56210610
110PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.56207593
111PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.56086501
112GATA2_22383799_ChIP-Seq_G1ME_Mouse0.54316754
113* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.54302594
114UTX_26944678_Chip-Seq_JUKART_Human0.54115899
115DCP1A_22483619_ChIP-Seq_HELA_Human0.54085893
116* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.53554336
117SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.53249151
118MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.53059880

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.95943240
2MP0003111_abnormal_nucleus_morphology4.21951743
3MP0010307_abnormal_tumor_latency4.07852356
4MP0003693_abnormal_embryo_hatching3.89101507
5MP0003077_abnormal_cell_cycle3.74221973
6MP0010352_gastrointestinal_tract_polyps3.65028156
7MP0004957_abnormal_blastocyst_morpholog3.62741800
8MP0003705_abnormal_hypodermis_morpholog3.17879732
9MP0008057_abnormal_DNA_replication3.17134001
10MP0003763_abnormal_thymus_physiology2.65912126
11MP0005076_abnormal_cell_differentiation2.60073312
12MP0009697_abnormal_copulation2.51668828
13MP0003123_paternal_imprinting2.41997692
14MP0008932_abnormal_embryonic_tissue2.41411679
15MP0000350_abnormal_cell_proliferation2.40323889
16MP0008058_abnormal_DNA_repair2.39859020
17MP0003656_abnormal_erythrocyte_physiolo2.37163502
18MP0008007_abnormal_cellular_replicative2.28199132
19MP0001730_embryonic_growth_arrest2.26894711
20MP0010234_abnormal_vibrissa_follicle2.21808038
21MP0004197_abnormal_fetal_growth/weight/1.90302707
22MP0004147_increased_porphyrin_level1.89263410
23MP0004381_abnormal_hair_follicle1.87095463
24MP0003121_genomic_imprinting1.86361529
25MP0002086_abnormal_extraembryonic_tissu1.82624004
26MP0004808_abnormal_hematopoietic_stem1.77683093
27MP0000537_abnormal_urethra_morphology1.75762215
28MP0001697_abnormal_embryo_size1.73494869
29MP0002084_abnormal_developmental_patter1.72692147
30MP0005380_embryogenesis_phenotype1.72424847
31MP0001672_abnormal_embryogenesis/_devel1.72424847
32MP0005464_abnormal_platelet_physiology1.71160051
33MP0001835_abnormal_antigen_presentation1.68037182
34MP0002085_abnormal_embryonic_tissue1.66121253
35MP0000490_abnormal_crypts_of1.63048971
36MP0002080_prenatal_lethality1.60007734
37MP0000685_abnormal_immune_system1.57379505
38MP0001661_extended_life_span1.56752853
39MP0002877_abnormal_melanocyte_morpholog1.53544971
40MP0002396_abnormal_hematopoietic_system1.52099875
41MP0003984_embryonic_growth_retardation1.49170056
42MP0002088_abnormal_embryonic_growth/wei1.47642886
43MP0008877_abnormal_DNA_methylation1.45109621
44MP0003937_abnormal_limbs/digits/tail_de1.44128636
45MP0006054_spinal_hemorrhage1.41820803
46MP0002019_abnormal_tumor_incidence1.40205991
47MP0005623_abnormal_meninges_morphology1.39145730
48MP0009053_abnormal_anal_canal1.39096703
49MP0003786_premature_aging1.37133352
50MP0001293_anophthalmia1.32565617
51MP0010030_abnormal_orbit_morphology1.30163052
52MP0003806_abnormal_nucleotide_metabolis1.23008360
53MP0000733_abnormal_muscle_development1.20947569
54MP0000313_abnormal_cell_death1.19765617
55MP0000703_abnormal_thymus_morphology1.19298852
56MP0005645_abnormal_hypothalamus_physiol1.17847278
57MP0000465_gastrointestinal_hemorrhage1.17544038
58MP0002697_abnormal_eye_size1.17110110
59MP0001800_abnormal_humoral_immune1.16080328
60MP0002092_abnormal_eye_morphology1.12370316
61MP0008438_abnormal_cutaneous_collagen1.11252488
62MP0000569_abnormal_digit_pigmentation1.11014470
63MP0003566_abnormal_cell_adhesion1.10750542
64MP0003890_abnormal_embryonic-extraembry1.08180038
65MP0002111_abnormal_tail_morphology1.06301436
66MP0002138_abnormal_hepatobiliary_system1.06243938
67MP0005671_abnormal_response_to1.05035867
68MP0006035_abnormal_mitochondrial_morpho1.04215330
69MP0000358_abnormal_cell_content/1.03938972
70MP0009703_decreased_birth_body1.02237439
71MP0000716_abnormal_immune_system0.99397467
72MP0002160_abnormal_reproductive_system0.98947201
73MP0005220_abnormal_exocrine_pancreas0.97482832
74MP0004185_abnormal_adipocyte_glucose0.96588991
75MP0003567_abnormal_fetal_cardiomyocyte0.96436003
76MP0002009_preneoplasia0.93932993
77MP0008770_decreased_survivor_rate0.92530628
78MP0004947_skin_inflammation0.92456740
79MP0002722_abnormal_immune_system0.91452423
80MP0001915_intracranial_hemorrhage0.90260186
81MP0002163_abnormal_gland_morphology0.89360009
82MP0002925_abnormal_cardiovascular_devel0.88347924
83MP0002166_altered_tumor_susceptibility0.87739465
84MP0002398_abnormal_bone_marrow0.87581894
85MP0009672_abnormal_birth_weight0.87093177
86MP0005023_abnormal_wound_healing0.87086687
87MP0000428_abnormal_craniofacial_morphol0.86324689
88MP0005621_abnormal_cell_physiology0.84936035
89MP0001286_abnormal_eye_development0.84780733
90MP0003119_abnormal_digestive_system0.84280767
91MP0010678_abnormal_skin_adnexa0.81803642
92MP0005075_abnormal_melanosome_morpholog0.81587941
93MP0003787_abnormal_imprinting0.79212561
94MP0000015_abnormal_ear_pigmentation0.79179271
95MP0001849_ear_inflammation0.78694606
96MP0005384_cellular_phenotype0.77896031
97MP0005000_abnormal_immune_tolerance0.77851365
98MP0005083_abnormal_biliary_tract0.77746345
99MP0004134_abnormal_chest_morphology0.77479641
100MP0005501_abnormal_skin_physiology0.76978136
101MP0000689_abnormal_spleen_morphology0.76420136
102MP0002420_abnormal_adaptive_immunity0.75909457
103MP0001929_abnormal_gametogenesis0.74932047
104MP0002006_tumorigenesis0.74680955
105MP0000477_abnormal_intestine_morphology0.72959474
106MP0003861_abnormal_nervous_system0.72821860
107MP0000432_abnormal_head_morphology0.72566314
108MP0003453_abnormal_keratinocyte_physiol0.72041288
109MP0001819_abnormal_immune_cell0.71716352
110MP0003300_gastrointestinal_ulcer0.71692870
111MP0005187_abnormal_penis_morphology0.71490500
112MP0009278_abnormal_bone_marrow0.70462585
113MP0001216_abnormal_epidermal_layer0.69676497
114MP0005647_abnormal_sex_gland0.68207895
115MP0001879_abnormal_lymphatic_vessel0.67353791
116MP0006072_abnormal_retinal_apoptosis0.66801412
117MP0001191_abnormal_skin_condition0.66345925
118MP0005397_hematopoietic_system_phenotyp0.65514209
119MP0001545_abnormal_hematopoietic_system0.65514209
120MP0003091_abnormal_cell_migration0.65444188
121MP0004233_abnormal_muscle_weight0.64294606
122MP0003699_abnormal_female_reproductive0.62564423
123MP0003115_abnormal_respiratory_system0.62451220
124MP0002452_abnormal_antigen_presenting0.62269870
125MP0001119_abnormal_female_reproductive0.61950341
126MP0003283_abnormal_digestive_organ0.61403743
127MP0003448_altered_tumor_morphology0.61346208
128MP0003718_maternal_effect0.60972373
129MP0000266_abnormal_heart_morphology0.60937307
130MP0000377_abnormal_hair_follicle0.60536053
131MP0002098_abnormal_vibrissa_morphology0.59857567
132MP0002405_respiratory_system_inflammati0.59842293
133MP0001243_abnormal_dermal_layer0.59568553
134MP0002210_abnormal_sex_determination0.58870246
135MP0005275_abnormal_skin_tensile0.57589155
136MP0003315_abnormal_perineum_morphology0.57525694
137MP0001145_abnormal_male_reproductive0.57346456
138MP0002429_abnormal_blood_cell0.57281589
139MP0003935_abnormal_craniofacial_develop0.56872897
140MP0009931_abnormal_skin_appearance0.55672455

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)4.55167626
2Poikilocytosis (HP:0004447)4.31745911
3IgA deficiency (HP:0002720)4.27955567
4Colitis (HP:0002583)3.95879507
5Reticulocytopenia (HP:0001896)3.92591194
6Hypochromic microcytic anemia (HP:0004840)3.69091475
7Thyroiditis (HP:0100646)3.68892174
8Chromsome breakage (HP:0040012)3.58438306
9Medulloblastoma (HP:0002885)3.55460134
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.40835346
11Abnormality of chromosome stability (HP:0003220)3.35468392
12Rhabdomyosarcoma (HP:0002859)3.32519062
13Astrocytoma (HP:0009592)3.26481381
14Abnormality of the astrocytes (HP:0100707)3.26481381
15Cutaneous melanoma (HP:0012056)3.24933807
16Short 4th metacarpal (HP:0010044)3.21348681
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.21348681
18Glioma (HP:0009733)3.20871570
19Nephroblastoma (Wilms tumor) (HP:0002667)3.17005840
20Ependymoma (HP:0002888)3.13771765
21Abnormality of reticulocytes (HP:0004312)3.08934862
22Abnormality of the labia minora (HP:0012880)3.08833163
23Panhypogammaglobulinemia (HP:0003139)3.06087741
24Volvulus (HP:0002580)3.03043882
25Clubbing of toes (HP:0100760)3.02991820
26Birth length less than 3rd percentile (HP:0003561)3.01971384
27Embryonal renal neoplasm (HP:0011794)2.93510248
28Combined immunodeficiency (HP:0005387)2.88965276
29Abnormality of the heme biosynthetic pathway (HP:0010472)2.88618903
30Acanthocytosis (HP:0001927)2.87581928
31Severe combined immunodeficiency (HP:0004430)2.87139326
32Colon cancer (HP:0003003)2.85204038
33Increased mean platelet volume (HP:0011877)2.80115996
34Impulsivity (HP:0100710)2.79849034
35Abnormality of cells of the erythroid lineage (HP:0012130)2.78891584
36Selective tooth agenesis (HP:0001592)2.76811310
37Autoimmune hemolytic anemia (HP:0001890)2.76061052
38Abnormal platelet volume (HP:0011876)2.68222645
39Basal cell carcinoma (HP:0002671)2.63032843
40Reticulocytosis (HP:0001923)2.61878176
41Abnormality of pyrimidine metabolism (HP:0004353)2.60451112
42Abnormality of the fingertips (HP:0001211)2.60129576
43Abnormality of the parietal bone (HP:0002696)2.58919820
44Recurrent viral infections (HP:0004429)2.56299486
45Cafe-au-lait spot (HP:0000957)2.50749153
46Lymphoma (HP:0002665)2.50530648
47Agnosia (HP:0010524)2.49956264
48Squamous cell carcinoma (HP:0002860)2.49468628
49Deviation of the thumb (HP:0009603)2.48657638
50Increased nuchal translucency (HP:0010880)2.44023307
51Neoplasm of striated muscle (HP:0009728)2.43147313
52Sandal gap (HP:0001852)2.42636521
53Biliary tract neoplasm (HP:0100574)2.41514351
54Prostate neoplasm (HP:0100787)2.40202208
55Proximal placement of thumb (HP:0009623)2.36928845
56Short thumb (HP:0009778)2.35797950
57High pitched voice (HP:0001620)2.35197572
58Neoplasm of the oral cavity (HP:0100649)2.33771196
59Ulnar bowing (HP:0003031)2.32874347
60Abnormality of DNA repair (HP:0003254)2.32811055
61Small intestinal stenosis (HP:0012848)2.32649096
62Duodenal stenosis (HP:0100867)2.32649096
63Neoplasm of the heart (HP:0100544)2.32191871
64Duplicated collecting system (HP:0000081)2.29692293
65Abnormality of the 4th metacarpal (HP:0010012)2.29354745
66Macrocytic anemia (HP:0001972)2.28976169
67Pallor (HP:0000980)2.26812313
68Patellar aplasia (HP:0006443)2.25087131
69Cellulitis (HP:0100658)2.24456723
70Inflammation of the large intestine (HP:0002037)2.24447661
71Missing ribs (HP:0000921)2.22778955
72Meckel diverticulum (HP:0002245)2.21494547
7311 pairs of ribs (HP:0000878)2.21351027
74Malignant gastrointestinal tract tumors (HP:0006749)2.19932819
75Gastrointestinal carcinoma (HP:0002672)2.19932819
76Aplasia/Hypoplasia of the uvula (HP:0010293)2.19814501
77Hypoplasia of the thymus (HP:0000778)2.19468833
78Cortical dysplasia (HP:0002539)2.19056090
79Heterotopia (HP:0002282)2.18553042
80Abnormal number of erythroid precursors (HP:0012131)2.18249325
81Prominent nose (HP:0000448)2.15960774
82Abnormality of the renal collecting system (HP:0004742)2.12935811
83Acute myeloid leukemia (HP:0004808)2.11571375
84Leiomyosarcoma (HP:0100243)2.11438203
85Uterine leiomyosarcoma (HP:0002891)2.11438203
86Abnormality of the preputium (HP:0100587)2.11204563
87Gastrointestinal inflammation (HP:0004386)2.10012670
88Myelodysplasia (HP:0002863)2.09513337
89Papillary thyroid carcinoma (HP:0002895)2.08499583
90Deep philtrum (HP:0002002)2.07834250
91Abnormality of the ileum (HP:0001549)2.07649823
92Arteriovenous malformation (HP:0100026)2.06349240
93Aplasia/Hypoplasia of the patella (HP:0006498)2.05997880
94Prolonged bleeding time (HP:0003010)2.05889329
95Atresia of the external auditory canal (HP:0000413)2.05683668
96Freckling (HP:0001480)2.05192185
97Sloping forehead (HP:0000340)2.04237949
98Petechiae (HP:0000967)2.03968598
99Hypopigmentation of the fundus (HP:0007894)2.03943301
100Ankyloglossia (HP:0010296)2.03649901
101Bone marrow hypocellularity (HP:0005528)2.02881301
102Ectopic kidney (HP:0000086)2.01649938
103Short phalanx of the thumb (HP:0009660)1.99726894
104Absent thumb (HP:0009777)1.98742184
105Bladder carcinoma (HP:0002862)1.97195552
106Bladder neoplasm (HP:0009725)1.97195552
107Abnormality of oral frenula (HP:0000190)1.97182574
108Wrist flexion contracture (HP:0001239)1.95799512
109Down-sloping shoulders (HP:0200021)1.94287471
110Ankle contracture (HP:0006466)1.93744356
111Aplasia/Hypoplasia of the sternum (HP:0006714)1.93213703
112Abnormality of chromosome segregation (HP:0002916)1.93095317
113Viral hepatitis (HP:0006562)1.92601626
114Transitional cell carcinoma of the bladder (HP:0006740)1.92389066
115Agammaglobulinemia (HP:0004432)1.91993799
116Neoplasm of the pancreas (HP:0002894)1.91913369
117Abnormality of the prostate (HP:0008775)1.90852591
118Intestinal polyposis (HP:0200008)1.90659890
119Short humerus (HP:0005792)1.88835759
120Ovarian neoplasm (HP:0100615)1.88411183
121Abnormality of the duodenum (HP:0002246)1.88053550
122Spastic diplegia (HP:0001264)1.87916480
123Abnormal number of incisors (HP:0011064)1.87865811
124Abnormality of the calcaneus (HP:0008364)1.87473028
125Abnormality of the carotid arteries (HP:0005344)1.87028656
126Absent radius (HP:0003974)1.86921442
127Embryonal neoplasm (HP:0002898)1.84951912
128Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.84481797
129Amaurosis fugax (HP:0100576)1.84289714
130Intestinal polyp (HP:0005266)1.83296303
131Absent frontal sinuses (HP:0002688)1.83269472
132Poikiloderma (HP:0001029)1.82622839
133Leukopenia (HP:0001882)1.81112297
134Hypergonadotropic hypogonadism (HP:0000815)1.80395648
135Abnormality of the distal phalanx of the thumb (HP:0009617)1.79906786
136Aplasia/hypoplasia of the humerus (HP:0006507)1.79609335
137Lymphopenia (HP:0001888)1.78933279
138Deformed sella turcica (HP:0002681)1.78566185
139Abnormal lung lobation (HP:0002101)1.78294646
140B lymphocytopenia (HP:0010976)1.77810337
141Abnormality of B cell number (HP:0010975)1.77810337
142Oral leukoplakia (HP:0002745)1.76494807
143Large earlobe (HP:0009748)1.74784737
144Cellular immunodeficiency (HP:0005374)1.73964336
145Gastrointestinal stroma tumor (HP:0100723)1.73016372
146Acute lymphatic leukemia (HP:0006721)1.72364900
147Neoplasm of the small intestine (HP:0100833)1.72306570
148Insomnia (HP:0100785)1.72039841
149Aplasia involving forearm bones (HP:0009822)1.71132805
150Absent forearm bone (HP:0003953)1.71132805
151Dyschromatopsia (HP:0007641)1.69415010
152Fibrous tissue neoplasm (HP:0012316)1.68524090
153Uterine neoplasm (HP:0010784)1.68338557
154Orthostatic hypotension (HP:0001278)1.67568183
155Sparse lateral eyebrow (HP:0005338)1.67337617
156Abnormality of cells of the lymphoid lineage (HP:0012140)1.67032103
157Cutis marmorata (HP:0000965)1.66877066
158Aplasia/Hypoplasia of the sacrum (HP:0008517)1.65655970
159Erythema (HP:0010783)1.65092427

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.33506785
2ZAK6.14009877
3CDC73.38815556
4VRK13.38457947
5STK42.95952736
6RPS6KA52.73863753
7NEK22.19364799
8EEF2K2.03150013
9CDK91.97034706
10AURKB1.79006519
11SCYL21.75932104
12WEE11.75379593
13MAP3K101.71727583
14BUB11.71061824
15PKN21.68263837
16CDK121.60926972
17SRPK11.60909265
18MAP3K81.59142202
19DAPK31.59018899
20CHEK21.52214383
21SMG11.49112716
22TAF11.44277646
23PIM11.43615261
24EPHA21.35522400
25NEK11.30164774
26TTK1.29930796
27RPS6KB21.29665027
28ACVR1B1.28695001
29EIF2AK11.28419957
30PASK1.21509098
31ATR1.20849620
32TTN1.17880875
33NME21.13818579
34PLK11.12112510
35DYRK30.95425381
36NLK0.94468994
37PKN10.94457526
38AURKA0.93140352
39PLK30.90776446
40BTK0.89098498
41GRK60.82920405
42STK100.82492454
43FLT30.82158151
44MELK0.81683864
45CDK40.77886376
46CDK80.76760504
47CHEK10.76697555
48TGFBR10.76276732
49TESK20.76151515
50ATM0.74632416
51MST40.74226238
52BRSK20.72662914
53CCNB10.72296513
54CDK60.70382835
55CDK20.65448111
56LATS10.65002487
57DYRK1B0.64645700
58PIK3CG0.62265732
59STK30.60570047
60FRK0.57500001
61LRRK20.55717362
62BRAF0.54698998
63SYK0.54227099
64CAMK1D0.53458478
65TSSK60.53454589
66ICK0.52717775
67AKT20.52233443
68CDK10.51568635
69ALK0.51492257
70CDK70.50716211
71BMPR1B0.49466155
72FGFR20.48345064
73CSNK1D0.47185797
74PRPF4B0.46598704
75EIF2AK30.44506735
76MAPK110.43422815
77CAMKK20.42781889
78MAP3K20.41623714
79KSR10.41028181
80PRKAA10.39298721
81CAMK40.38208634
82RPS6KA40.37443645
83BRSK10.37422260
84EIF2AK20.36599729
85PDGFRA0.36199294
86TEC0.35226473
87MTOR0.34507302
88PBK0.34163433
89PAK10.33653517
90MAP3K40.33621605
91PRKDC0.33342713
92MAP2K70.32092713
93ROCK10.31262162
94BLK0.30402760
95RAF10.29588938
96TESK10.29071496
97ERBB40.28276535
98PTK60.26590371
99NEK90.25843855
100TRIB30.25440072
101PAK20.24886556
102BRD40.24294998
103CSNK2A20.23979655
104MAPK140.23333418
105PAK40.23156344
106MKNK10.23090237
107JAK20.22861752
108RPS6KB10.22001223
109TRPM70.21627874
110BMPR20.20838832
111CSNK1A1L0.20757798
112PLK40.20710322
113MET0.20695667
114MAPKAPK50.20440881
115BMX0.19801854
116CSNK1G30.19761077
117AKT10.18991822
118CAMK1G0.18546928
119ILK0.18182728
120FGR0.17526238
121CSNK1G10.17440790
122LYN0.17352661
123PIM20.16278953
124ERBB20.15734712
125AKT30.14961123
126NUAK10.14694165
127HIPK20.14340121
128PRKCQ0.14318857
129FGFR10.14122226
130HCK0.13882671
131MARK30.13245043
132PDGFRB0.12818285
133RPS6KA30.12764354
134RIPK10.12631670
135MAP2K30.11888658
136NEK60.11678131
137PRKCI0.11413064
138RET0.10684841
139MKNK20.10334962
140GSK3B0.09906811
141SGK20.08536655

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.44096185
2* Viral carcinogenesis_Homo sapiens_hsa052033.34389863
3DNA replication_Homo sapiens_hsa030302.90895149
4Mismatch repair_Homo sapiens_hsa034302.60240834
5One carbon pool by folate_Homo sapiens_hsa006702.15577835
6Cell cycle_Homo sapiens_hsa041102.09371494
7* Systemic lupus erythematosus_Homo sapiens_hsa0532211.2543251
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.87207513
9Transcriptional misregulation in cancer_Homo sapiens_hsa052021.75728839
10Non-homologous end-joining_Homo sapiens_hsa034501.75235905
11RNA transport_Homo sapiens_hsa030131.69528223
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66236300
13Ribosome_Homo sapiens_hsa030101.66125900
14Nucleotide excision repair_Homo sapiens_hsa034201.62215451
15Homologous recombination_Homo sapiens_hsa034401.54897754
16Fanconi anemia pathway_Homo sapiens_hsa034601.48958861
17Spliceosome_Homo sapiens_hsa030401.41936099
18Base excision repair_Homo sapiens_hsa034101.32923910
19p53 signaling pathway_Homo sapiens_hsa041151.16350348
20Primary immunodeficiency_Homo sapiens_hsa053401.11864254
21mRNA surveillance pathway_Homo sapiens_hsa030151.10091685
22MicroRNAs in cancer_Homo sapiens_hsa052060.98619071
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88879316
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86394906
25Selenocompound metabolism_Homo sapiens_hsa004500.85621401
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77165590
27Intestinal immune network for IgA production_Homo sapiens_hsa046720.75191028
28Pyrimidine metabolism_Homo sapiens_hsa002400.75058295
29Small cell lung cancer_Homo sapiens_hsa052220.74373085
30RNA degradation_Homo sapiens_hsa030180.73563647
31Oocyte meiosis_Homo sapiens_hsa041140.72662918
32Chronic myeloid leukemia_Homo sapiens_hsa052200.70932473
33Bladder cancer_Homo sapiens_hsa052190.66409567
34HTLV-I infection_Homo sapiens_hsa051660.65307293
35RNA polymerase_Homo sapiens_hsa030200.62250073
36Non-small cell lung cancer_Homo sapiens_hsa052230.59801755
37Cyanoamino acid metabolism_Homo sapiens_hsa004600.59284337
38Colorectal cancer_Homo sapiens_hsa052100.47975057
39Antigen processing and presentation_Homo sapiens_hsa046120.47401394
40Asthma_Homo sapiens_hsa053100.46912661
41TGF-beta signaling pathway_Homo sapiens_hsa043500.45760177
42Epstein-Barr virus infection_Homo sapiens_hsa051690.45035875
43Thyroid cancer_Homo sapiens_hsa052160.44114705
44Acute myeloid leukemia_Homo sapiens_hsa052210.42610037
45Herpes simplex infection_Homo sapiens_hsa051680.41940707
46Apoptosis_Homo sapiens_hsa042100.40901133
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40455109
48Pancreatic cancer_Homo sapiens_hsa052120.40181720
49Glioma_Homo sapiens_hsa052140.39906568
50mTOR signaling pathway_Homo sapiens_hsa041500.39074778
51Hippo signaling pathway_Homo sapiens_hsa043900.38388912
52Autoimmune thyroid disease_Homo sapiens_hsa053200.38131319
53Biosynthesis of amino acids_Homo sapiens_hsa012300.37981120
54Allograft rejection_Homo sapiens_hsa053300.36896531
55Proteoglycans in cancer_Homo sapiens_hsa052050.36393872
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.36002573
57Prostate cancer_Homo sapiens_hsa052150.35575289
58Lysine degradation_Homo sapiens_hsa003100.34560367
59Hepatitis B_Homo sapiens_hsa051610.32867012
60FoxO signaling pathway_Homo sapiens_hsa040680.31946257
61Adherens junction_Homo sapiens_hsa045200.30313167
62Basal cell carcinoma_Homo sapiens_hsa052170.30181444
63Melanoma_Homo sapiens_hsa052180.30148436
64Graft-versus-host disease_Homo sapiens_hsa053320.29652199
65Tight junction_Homo sapiens_hsa045300.29546163
66Endometrial cancer_Homo sapiens_hsa052130.29041417
67Inositol phosphate metabolism_Homo sapiens_hsa005620.28814345
68Viral myocarditis_Homo sapiens_hsa054160.28718320
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.27433938
70T cell receptor signaling pathway_Homo sapiens_hsa046600.27404618
71Pentose phosphate pathway_Homo sapiens_hsa000300.26301925
72Purine metabolism_Homo sapiens_hsa002300.25984776
73Basal transcription factors_Homo sapiens_hsa030220.25675560
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25113182
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24810877
76Renin-angiotensin system_Homo sapiens_hsa046140.24727886
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24168313
78ErbB signaling pathway_Homo sapiens_hsa040120.23975804
79Focal adhesion_Homo sapiens_hsa045100.23015236
80Pathways in cancer_Homo sapiens_hsa052000.22746057
81Influenza A_Homo sapiens_hsa051640.22144955
82Vitamin B6 metabolism_Homo sapiens_hsa007500.21727638
83Sulfur relay system_Homo sapiens_hsa041220.21463344
84Legionellosis_Homo sapiens_hsa051340.20956165
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19920575
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.18729317
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.17075026
88Leishmaniasis_Homo sapiens_hsa051400.16689390
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.16242806
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16034320
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15367400
92N-Glycan biosynthesis_Homo sapiens_hsa005100.15112642
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.14972094
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.14206768
95B cell receptor signaling pathway_Homo sapiens_hsa046620.13592384
96Measles_Homo sapiens_hsa051620.13221779
97AMPK signaling pathway_Homo sapiens_hsa041520.12676983
98Hematopoietic cell lineage_Homo sapiens_hsa046400.12579250
99Type I diabetes mellitus_Homo sapiens_hsa049400.12371102
100Notch signaling pathway_Homo sapiens_hsa043300.12225587
101Renal cell carcinoma_Homo sapiens_hsa052110.12129589
102Proteasome_Homo sapiens_hsa030500.11485588
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.11178864
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.11006329
105HIF-1 signaling pathway_Homo sapiens_hsa040660.10739801
106ECM-receptor interaction_Homo sapiens_hsa045120.10495625
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.10395416
108Dorso-ventral axis formation_Homo sapiens_hsa043200.10213878
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09843207
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.09712578
111Prolactin signaling pathway_Homo sapiens_hsa049170.09214785
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08554090
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.08478730
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.08302848
115Platelet activation_Homo sapiens_hsa046110.07855074
116Nitrogen metabolism_Homo sapiens_hsa009100.07666475
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.06969838
118Carbon metabolism_Homo sapiens_hsa012000.06942807
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.06775905
120VEGF signaling pathway_Homo sapiens_hsa043700.06735038
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.05315133
122Hedgehog signaling pathway_Homo sapiens_hsa043400.04687764
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.04615992
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.04375498
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.04139864
126Wnt signaling pathway_Homo sapiens_hsa043100.03991872
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.03558959

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