HIST1H2BH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome organization (GO:0034723)8.41742370
2DNA replication-dependent nucleosome assembly (GO:0006335)8.41742370
3chromatin assembly (GO:0031497)7.68128194
4regulation of histone H3-K9 methylation (GO:0051570)7.31975882
5* nucleosome assembly (GO:0006334)6.79983460
6antibacterial humoral response (GO:0019731)6.22108892
7innate immune response in mucosa (GO:0002227)5.88964731
8* nucleosome organization (GO:0034728)5.87573202
9nuclear pore complex assembly (GO:0051292)5.85930450
10antimicrobial humoral response (GO:0019730)5.79115700
11DNA unwinding involved in DNA replication (GO:0006268)5.75786810
12mitotic chromosome condensation (GO:0007076)5.71271151
13* protein-DNA complex assembly (GO:0065004)5.70113663
14nuclear pore organization (GO:0006999)5.69700622
15protein localization to kinetochore (GO:0034501)5.69256519
16chromatin assembly or disassembly (GO:0006333)5.61423007
17negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)5.44354488
18sister chromatid segregation (GO:0000819)5.26136691
19protoporphyrinogen IX metabolic process (GO:0046501)5.10728113
20* protein-DNA complex subunit organization (GO:0071824)5.10167570
21protein localization to chromosome, centromeric region (GO:0071459)4.89969729
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.88583395
23mitotic sister chromatid segregation (GO:0000070)4.73400446
24folic acid-containing compound biosynthetic process (GO:0009396)4.69884955
25protoporphyrinogen IX biosynthetic process (GO:0006782)4.53365874
26mucosal immune response (GO:0002385)4.53009611
27pore complex assembly (GO:0046931)4.47144507
28regulation of megakaryocyte differentiation (GO:0045652)4.32426414
29organ or tissue specific immune response (GO:0002251)4.28225401
30DNA replication initiation (GO:0006270)4.25521191
31negative regulation of histone methylation (GO:0031061)4.16371538
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.14980557
33mitotic nuclear envelope disassembly (GO:0007077)4.06335778
34positive regulation of chromosome segregation (GO:0051984)4.04556913
35DNA duplex unwinding (GO:0032508)4.01514912
36DNA geometric change (GO:0032392)4.01034655
37CENP-A containing nucleosome assembly (GO:0034080)4.00954343
38positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.99816362
39positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.99816362
40positive regulation of mitotic sister chromatid separation (GO:1901970)3.99816362
41chromatin remodeling at centromere (GO:0031055)3.99191853
42erythrocyte maturation (GO:0043249)3.96843866
43regulation of centriole replication (GO:0046599)3.96445344
44protein K6-linked ubiquitination (GO:0085020)3.94519880
45DNA strand elongation involved in DNA replication (GO:0006271)3.90589003
46regulation of DNA endoreduplication (GO:0032875)3.89202141
47nuclear envelope disassembly (GO:0051081)3.85582088
48membrane disassembly (GO:0030397)3.85582088
49IMP biosynthetic process (GO:0006188)3.82573148
50kinetochore organization (GO:0051383)3.80775461
51dosage compensation (GO:0007549)3.80771892
52mitotic sister chromatid cohesion (GO:0007064)3.79384017
53chromosome condensation (GO:0030261)3.78325878
54defense response to Gram-positive bacterium (GO:0050830)3.71691065
55DNA strand elongation (GO:0022616)3.70326358
56DNA replication-independent nucleosome organization (GO:0034724)3.68062883
57DNA replication-independent nucleosome assembly (GO:0006336)3.68062883
58regulation of gene silencing (GO:0060968)3.63290490
59regulation of sister chromatid cohesion (GO:0007063)3.62716465
60mitotic recombination (GO:0006312)3.60081336
61telomere maintenance via semi-conservative replication (GO:0032201)3.59739944
62regulation of centrosome cycle (GO:0046605)3.53881999
63microtubule depolymerization (GO:0007019)3.53037244
64DNA topological change (GO:0006265)3.51803821
65positive regulation of histone methylation (GO:0031062)3.51381527
66meiotic chromosome segregation (GO:0045132)3.49336752
67translesion synthesis (GO:0019985)3.48393427
68attachment of spindle microtubules to kinetochore (GO:0008608)3.45646630
69porphyrin-containing compound biosynthetic process (GO:0006779)3.41446666
70IMP metabolic process (GO:0046040)3.40369393
71regulation of spindle organization (GO:0090224)3.40139739
72negative regulation of thymocyte apoptotic process (GO:0070244)3.37463237
73DNA conformation change (GO:0071103)3.36083688
74regulation of translational fidelity (GO:0006450)3.34491997
75regulation of centrosome duplication (GO:0010824)3.30919849
76histone exchange (GO:0043486)3.27705280
77DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.27096678
78telomere maintenance via recombination (GO:0000722)3.26577577
79protein localization to chromosome (GO:0034502)3.24836424
80B cell mediated immunity (GO:0019724)3.24303208
81DNA packaging (GO:0006323)3.21503775
82postreplication repair (GO:0006301)3.21487056
83mitotic metaphase plate congression (GO:0007080)3.20153994
84regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19453525
85regulation of chromosome segregation (GO:0051983)3.19011956
86DNA synthesis involved in DNA repair (GO:0000731)3.16280487
87non-recombinational repair (GO:0000726)3.16256362
88double-strand break repair via nonhomologous end joining (GO:0006303)3.16256362
89regulation of RNA export from nucleus (GO:0046831)3.14507384
90protein neddylation (GO:0045116)3.12307976
91metaphase plate congression (GO:0051310)3.11816891
92chromosome segregation (GO:0007059)3.11699794
93ribosomal small subunit assembly (GO:0000028)3.10287740
94telomere organization (GO:0032200)3.08587580
95positive regulation of histone H3-K4 methylation (GO:0051571)3.06635071
96somatic diversification of immune receptors via somatic mutation (GO:0002566)3.05906163
97somatic hypermutation of immunoglobulin genes (GO:0016446)3.05906163
98regulation of mitotic spindle organization (GO:0060236)3.04676254
99regulation of mitotic metaphase/anaphase transition (GO:0030071)3.00293533
100spindle checkpoint (GO:0031577)3.00216750
101negative regulation of chromosome segregation (GO:0051985)2.98784143
102nucleotide-excision repair, DNA gap filling (GO:0006297)2.98535523
103establishment of chromosome localization (GO:0051303)2.98200160
104pre-miRNA processing (GO:0031054)2.96416670
105V(D)J recombination (GO:0033151)2.94705030
106ATP-dependent chromatin remodeling (GO:0043044)2.94111395
107mitotic G1 DNA damage checkpoint (GO:0031571)2.93569454
108telomere maintenance (GO:0000723)2.93422587
109regulation of histone methylation (GO:0031060)2.92921509
110nuclear envelope organization (GO:0006998)2.92357404
111regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.91912514
112telomere maintenance via telomere lengthening (GO:0010833)2.90139713
113DNA replication checkpoint (GO:0000076)2.89850057
114mitotic DNA integrity checkpoint (GO:0044774)2.89460477
115negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.87247131
116negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.87247131
117negative regulation of mitotic sister chromatid segregation (GO:0033048)2.87247131
118negative regulation of mitotic sister chromatid separation (GO:2000816)2.87247131
119negative regulation of sister chromatid segregation (GO:0033046)2.87247131
120regulation of sister chromatid segregation (GO:0033045)2.83161550
121regulation of mitotic sister chromatid separation (GO:0010965)2.83161550
122regulation of mitotic sister chromatid segregation (GO:0033047)2.83161550
123regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.74845218
124somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.70389335
125somatic cell DNA recombination (GO:0016444)2.70389335
126mitotic spindle assembly checkpoint (GO:0007094)2.69920896
127maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.69119792
128immunoglobulin mediated immune response (GO:0016064)2.68590536
129polyamine biosynthetic process (GO:0006596)2.67353927
130spindle assembly checkpoint (GO:0071173)2.65513634
131negative regulation of DNA repair (GO:0045738)2.65127357
132mitotic spindle checkpoint (GO:0071174)2.64710535
133DNA double-strand break processing (GO:0000729)2.59002107
134rRNA transcription (GO:0009303)2.57305002
135DNA ligation (GO:0006266)2.57255686

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.12622834
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.80587271
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.32424037
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.84845627
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.61449615
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.85404790
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.62306567
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.40647877
9* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.22480687
10* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21651098
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.20361331
12* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.16481375
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse15.1539940
14* SOX2_16153702_ChIP-ChIP_HESCs_Human1.90553389
15IRF1_19129219_ChIP-ChIP_H3396_Human1.90551966
16NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89389550
17MYC_18555785_ChIP-Seq_MESCs_Mouse1.85444208
18EGR1_19374776_ChIP-ChIP_THP-1_Human1.80546647
19* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.79262348
20TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.73424697
21MYC_19030024_ChIP-ChIP_MESCs_Mouse1.66304622
22AR_21909140_ChIP-Seq_LNCAP_Human1.61290678
23* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.51069862
24* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48192766
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47194940
26* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44346324
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.41518126
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39865514
29HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.39422994
30HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39079077
31GATA1_22025678_ChIP-Seq_K562_Human1.37682938
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.36522586
33HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.36455747
34* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34061336
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32634613
36SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31952340
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31394639
38KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.31009639
39* VDR_23849224_ChIP-Seq_CD4+_Human1.26618478
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23623445
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22838666
42MYC_22102868_ChIP-Seq_BL_Human1.19938066
43ELK1_19687146_ChIP-ChIP_HELA_Human1.19136848
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15955122
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11538218
46KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10369428
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10159941
48DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07840171
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03558429
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03270727
51* NANOG_16153702_ChIP-ChIP_HESCs_Human1.01189924
52MYC_18358816_ChIP-ChIP_MESCs_Mouse0.99207675
53SOX2_18692474_ChIP-Seq_MESCs_Mouse0.99108052
54PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99008488
55STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94713492
56CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93694362
57E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92217541
58TCF3_18692474_ChIP-Seq_MESCs_Mouse0.91135782
59VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90946689
60NANOG_18555785_ChIP-Seq_MESCs_Mouse0.90828864
61VDR_21846776_ChIP-Seq_THP-1_Human0.90720333
62FOXP3_21729870_ChIP-Seq_TREG_Human0.90086661
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90029928
64SALL4_22934838_ChIP-ChIP_CD34+_Human0.89560822
65RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88570326
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88342684
67THAP11_20581084_ChIP-Seq_MESCs_Mouse0.87538377
68ETS1_22383799_ChIP-Seq_G1ME_Mouse0.85826927
69SALL1_21062744_ChIP-ChIP_HESCs_Human0.85016453
70GATA1_19941826_ChIP-Seq_K562_Human0.85004502
71XRN2_22483619_ChIP-Seq_HELA_Human0.84607323
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84364805
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.82907965
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.81728964
75SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.81343674
76MYCN_18555785_ChIP-Seq_MESCs_Mouse0.80724477
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80207306
78KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.78492409
79CREB1_15753290_ChIP-ChIP_HEK293T_Human0.78473856
80* MAF_26560356_Chip-Seq_TH1_Human0.76516303
81* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.75414957
82GATA2_22383799_ChIP-Seq_G1ME_Mouse0.75351233
83GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71030753
84PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.70800360
85SCL_19346495_ChIP-Seq_HPC-7_Human0.70710501
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.70042400
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.69778921
88EST1_17652178_ChIP-ChIP_JURKAT_Human0.69350039
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.69082182
90CIITA_25753668_ChIP-Seq_RAJI_Human0.68784544
91ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.68051411
92HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.66124165
93ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.65914823
94KDM5A_27292631_Chip-Seq_BREAST_Human0.65197448
95MYB_26560356_Chip-Seq_TH1_Human0.65143804
96NOTCH1_21737748_ChIP-Seq_TLL_Human0.64272306
97MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.63987315
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.63074105
99NANOG_21062744_ChIP-ChIP_HESCs_Human0.62554986
100MYC_18940864_ChIP-ChIP_HL60_Human0.62263633
101DCP1A_22483619_ChIP-Seq_HELA_Human0.61826698
102UTX_26944678_Chip-Seq_JUKART_Human0.61658875
103PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.61129570
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.60189702
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.58421731
106SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.57130568
107HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.56875913
108ELF1_17652178_ChIP-ChIP_JURKAT_Human0.56781094
109E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.56553143
110ZNF263_19887448_ChIP-Seq_K562_Human0.56483651
111MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.55840768
112TCF7_22412390_ChIP-Seq_EML_Mouse0.55767053
113MYB_26560356_Chip-Seq_TH2_Human0.55573133
114TDRD3_21172665_ChIP-Seq_MCF-7_Human0.53773784
115SOX17_20123909_ChIP-Seq_XEN_Mouse0.51658285
116PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.48794077

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.87765876
2MP0003111_abnormal_nucleus_morphology4.19147975
3MP0003656_abnormal_erythrocyte_physiolo4.02531266
4MP0010307_abnormal_tumor_latency3.91673874
5MP0005464_abnormal_platelet_physiology3.65073173
6MP0003693_abnormal_embryo_hatching3.63677187
7MP0003077_abnormal_cell_cycle3.55828158
8MP0004147_increased_porphyrin_level3.38523577
9MP0010352_gastrointestinal_tract_polyps3.07609220
10MP0008057_abnormal_DNA_replication2.98283030
11MP0004957_abnormal_blastocyst_morpholog2.92931436
12MP0003705_abnormal_hypodermis_morpholog2.57486995
13MP0003941_abnormal_skin_development2.56289613
14MP0009697_abnormal_copulation2.49787775
15MP0005645_abnormal_hypothalamus_physiol2.40743612
16MP0001835_abnormal_antigen_presentation2.37430920
17MP0006054_spinal_hemorrhage2.18685998
18MP0000350_abnormal_cell_proliferation2.14650353
19MP0000372_irregular_coat_pigmentation2.10501629
20MP0008058_abnormal_DNA_repair2.07952133
21MP0010234_abnormal_vibrissa_follicle2.05884979
22MP0005171_absent_coat_pigmentation2.02106466
23MP0001730_embryonic_growth_arrest2.01088729
24MP0004808_abnormal_hematopoietic_stem1.98296413
25MP0005076_abnormal_cell_differentiation1.97229499
26MP0002877_abnormal_melanocyte_morpholog1.96100877
27MP0008007_abnormal_cellular_replicative1.95379641
28MP0002396_abnormal_hematopoietic_system1.92300428
29MP0005671_abnormal_response_to1.91935118
30MP0003718_maternal_effect1.88336967
31MP0008932_abnormal_embryonic_tissue1.86249596
32MP0003763_abnormal_thymus_physiology1.83120464
33MP0003123_paternal_imprinting1.70951053
34MP0008877_abnormal_DNA_methylation1.70267740
35MP0002095_abnormal_skin_pigmentation1.61341301
36MP0002086_abnormal_extraembryonic_tissu1.60376716
37MP0000490_abnormal_crypts_of1.59760149
38MP0004197_abnormal_fetal_growth/weight/1.59336650
39MP0003121_genomic_imprinting1.57945563
40MP0001697_abnormal_embryo_size1.54517173
41MP0001672_abnormal_embryogenesis/_devel1.51212821
42MP0005380_embryogenesis_phenotype1.51212821
43MP0002019_abnormal_tumor_incidence1.46480302
44MP0005408_hypopigmentation1.45342453
45MP0002080_prenatal_lethality1.44191303
46MP0002084_abnormal_developmental_patter1.41097098
47MP0001661_extended_life_span1.37990343
48MP0003183_abnormal_peptide_metabolism1.35165925
49MP0003984_embryonic_growth_retardation1.34323465
50MP0002088_abnormal_embryonic_growth/wei1.32387131
51MP0005083_abnormal_biliary_tract1.31350447
52MP0002085_abnormal_embryonic_tissue1.30561462
53MP0008004_abnormal_stomach_pH1.29942481
54MP0000703_abnormal_thymus_morphology1.29742607
55MP0003300_gastrointestinal_ulcer1.29181957
56MP0002398_abnormal_bone_marrow1.28792144
57MP0000371_diluted_coat_color1.27385876
58MP0000313_abnormal_cell_death1.26922165
59MP0000358_abnormal_cell_content/1.24702414
60MP0006035_abnormal_mitochondrial_morpho1.23200155
61MP0002722_abnormal_immune_system1.22520169
62MP0001545_abnormal_hematopoietic_system1.22035149
63MP0005397_hematopoietic_system_phenotyp1.22035149
64MP0004381_abnormal_hair_follicle1.21990580
65MP0000689_abnormal_spleen_morphology1.15908623
66MP0002166_altered_tumor_susceptibility1.12913499
67MP0002138_abnormal_hepatobiliary_system1.11776361
68MP0000569_abnormal_digit_pigmentation1.10889950
69MP0005000_abnormal_immune_tolerance1.09350339
70MP0003786_premature_aging1.07105200
71MP0001293_anophthalmia1.06665746
72MP0002075_abnormal_coat/hair_pigmentati1.06405398
73MP0002009_preneoplasia1.04567444
74MP0003566_abnormal_cell_adhesion1.04357715
75MP0001915_intracranial_hemorrhage1.02451731
76MP0008770_decreased_survivor_rate1.02154921
77MP0001790_abnormal_immune_system1.01838694
78MP0005387_immune_system_phenotype1.01838694
79MP0000733_abnormal_muscle_development1.00499051
80MP0005647_abnormal_sex_gland0.98335239
81MP0002254_reproductive_system_inflammat0.97924870
82MP0003890_abnormal_embryonic-extraembry0.97094504
83MP0000537_abnormal_urethra_morphology0.94929142
84MP0002092_abnormal_eye_morphology0.93893930
85MP0002429_abnormal_blood_cell0.92314130
86MP0010155_abnormal_intestine_physiology0.90224756
87MP0003567_abnormal_fetal_cardiomyocyte0.90219149
88MP0002006_tumorigenesis0.89257586
89MP0003937_abnormal_limbs/digits/tail_de0.88723283
90MP0009703_decreased_birth_body0.87986281
91MP0001819_abnormal_immune_cell0.87675589
92MP0005023_abnormal_wound_healing0.87594370
93MP0002723_abnormal_immune_serum0.87223272
94MP0000015_abnormal_ear_pigmentation0.84769875
95MP0003787_abnormal_imprinting0.83940739
96MP0005621_abnormal_cell_physiology0.82047255
97MP0002111_abnormal_tail_morphology0.81783894
98MP0008438_abnormal_cutaneous_collagen0.80661207
99MP0000685_abnormal_immune_system0.79418279
100MP0002697_abnormal_eye_size0.78960155
101MP0005384_cellular_phenotype0.78125059
102MP0009672_abnormal_birth_weight0.77686035
103MP0001186_pigmentation_phenotype0.77201414
104MP0005220_abnormal_exocrine_pancreas0.76199314
105MP0003303_peritoneal_inflammation0.76165432
106MP0009278_abnormal_bone_marrow0.74822462
107MP0003136_yellow_coat_color0.74079529
108MP0010678_abnormal_skin_adnexa0.73023752
109MP0001800_abnormal_humoral_immune0.72965545
110MP0005084_abnormal_gallbladder_morpholo0.71555775
111MP0000716_abnormal_immune_system0.70860795
112MP0009333_abnormal_splenocyte_physiolog0.67426681
113MP0002925_abnormal_cardiovascular_devel0.67339536
114MP0001849_ear_inflammation0.67277055
115MP0009053_abnormal_anal_canal0.66828666
116MP0005075_abnormal_melanosome_morpholog0.64464916
117MP0001191_abnormal_skin_condition0.63408447
118MP0003448_altered_tumor_morphology0.63007652
119MP0005310_abnormal_salivary_gland0.62678579
120MP0001929_abnormal_gametogenesis0.62541548
121MP0001727_abnormal_embryo_implantation0.62115990
122MP0005501_abnormal_skin_physiology0.61640416
123MP0000428_abnormal_craniofacial_morphol0.61606362
124MP0009931_abnormal_skin_appearance0.59748096
125MP0002452_abnormal_antigen_presenting0.59727489
126MP0002210_abnormal_sex_determination0.59539326
127MP0003699_abnormal_female_reproductive0.59127557
128MP0000465_gastrointestinal_hemorrhage0.57907165
129MP0003453_abnormal_keratinocyte_physiol0.57600141
130MP0004185_abnormal_adipocyte_glucose0.57384549
131MP0002938_white_spotting0.56711848
132MP0004947_skin_inflammation0.56621154
133MP0002420_abnormal_adaptive_immunity0.56045278
134MP0005623_abnormal_meninges_morphology0.55486210
135MP0004084_abnormal_cardiac_muscle0.54809774

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)6.36918521
2IgA deficiency (HP:0002720)5.97632967
3IgM deficiency (HP:0002850)5.87757452
4Increased mean platelet volume (HP:0011877)4.87106616
5Hypochromic microcytic anemia (HP:0004840)4.78026916
6Gastrointestinal stroma tumor (HP:0100723)4.31631836
7Abnormality of the heme biosynthetic pathway (HP:0010472)4.29367299
8Acanthocytosis (HP:0001927)4.24644811
9Petechiae (HP:0000967)4.24164714
10Prolonged bleeding time (HP:0003010)4.13032147
11Cutaneous melanoma (HP:0012056)3.89520615
12Chromsome breakage (HP:0040012)3.69370943
13Reticulocytosis (HP:0001923)3.68442064
14Abnormality of reticulocytes (HP:0004312)3.61925865
15Menorrhagia (HP:0000132)3.53010642
16Reticulocytopenia (HP:0001896)3.50341513
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.46360831
18Colitis (HP:0002583)3.36418172
19Abnormality of chromosome stability (HP:0003220)3.30219461
20Recurrent sinusitis (HP:0011108)3.29326166
21Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.09593038
22Short 4th metacarpal (HP:0010044)3.09593038
23Lymphopenia (HP:0001888)3.04723407
24Dyschromatopsia (HP:0007641)3.01792862
25Impulsivity (HP:0100710)2.97230231
26Hypopigmentation of the fundus (HP:0007894)2.95619312
27Abnormality of cells of the lymphoid lineage (HP:0012140)2.92214097
28Volvulus (HP:0002580)2.89887455
29Purpura (HP:0000979)2.87944056
30Spontaneous hematomas (HP:0007420)2.78973529
31Agammaglobulinemia (HP:0004432)2.74905370
32Recurrent bronchitis (HP:0002837)2.74286605
33Subacute progressive viral hepatitis (HP:0006572)2.70638521
34Epistaxis (HP:0000421)2.70529241
35Nephroblastoma (Wilms tumor) (HP:0002667)2.69952607
36Basal cell carcinoma (HP:0002671)2.67181298
37Uterine leiomyosarcoma (HP:0002891)2.65531534
38Leiomyosarcoma (HP:0100243)2.65531534
39Ependymoma (HP:0002888)2.65386879
40High pitched voice (HP:0001620)2.65324393
41Dry hair (HP:0011359)2.65091527
42Lymphoma (HP:0002665)2.64837385
43Birth length less than 3rd percentile (HP:0003561)2.61898861
44Cafe-au-lait spot (HP:0000957)2.59932460
45Agnosia (HP:0010524)2.56208895
46IgG deficiency (HP:0004315)2.56140444
47Medulloblastoma (HP:0002885)2.54747794
48Rhabdomyosarcoma (HP:0002859)2.52935685
49Embryonal renal neoplasm (HP:0011794)2.52265699
50Impaired platelet aggregation (HP:0003540)2.48868650
51Abnormal platelet function (HP:0011869)2.48868650
52Prominent nose (HP:0000448)2.48418669
53Abnormality of cells of the erythroid lineage (HP:0012130)2.46810875
54Clubbing of toes (HP:0100760)2.46372082
55Freckling (HP:0001480)2.45671506
56Hypochromic anemia (HP:0001931)2.43185441
57Inflammation of the large intestine (HP:0002037)2.42003766
58Cholelithiasis (HP:0001081)2.40816632
59Sandal gap (HP:0001852)2.36953056
60Selective tooth agenesis (HP:0001592)2.36639875
61Autoimmune hemolytic anemia (HP:0001890)2.34292580
62Ulnar bowing (HP:0003031)2.31632506
63Insomnia (HP:0100785)2.30137572
64Duodenal stenosis (HP:0100867)2.28018999
65Small intestinal stenosis (HP:0012848)2.28018999
66Myelodysplasia (HP:0002863)2.27829285
67Astrocytoma (HP:0009592)2.24728228
68Abnormality of the astrocytes (HP:0100707)2.24728228
69Increased nuchal translucency (HP:0010880)2.23758502
70Chronic diarrhea (HP:0002028)2.23118837
71Aplasia/Hypoplasia of the uvula (HP:0010293)2.21553144
72Meckel diverticulum (HP:0002245)2.21045149
73Colon cancer (HP:0003003)2.20392519
74Gastrointestinal inflammation (HP:0004386)2.19135141
75Papilloma (HP:0012740)2.18851287
76Verrucae (HP:0200043)2.18851287
77Squamous cell carcinoma (HP:0002860)2.18302556
78Abnormality of the labia minora (HP:0012880)2.16450108
79Absent frontal sinuses (HP:0002688)2.15716315
80Bladder carcinoma (HP:0002862)2.14478413
81Bladder neoplasm (HP:0009725)2.14478413
82Erythema (HP:0010783)2.14444344
83Abnormal number of erythroid precursors (HP:0012131)2.13490441
84Cortical dysplasia (HP:0002539)2.13376998
85Abnormality of the fingertips (HP:0001211)2.12556920
86Abnormality of the ileum (HP:0001549)2.12044467
87Transitional cell carcinoma of the bladder (HP:0006740)2.11893899
88B lymphocytopenia (HP:0010976)2.11870775
89Ridged nail (HP:0001807)2.11179628
90Abnormality of the prostate (HP:0008775)2.10677889
91Sloping forehead (HP:0000340)2.10227170
92Deviation of the thumb (HP:0009603)2.08923354
93Abnormality of the 4th metacarpal (HP:0010012)2.07200772
94Leukopenia (HP:0001882)2.07138548
95Abnormality of the preputium (HP:0100587)2.06363423
96Abnormal gallbladder morphology (HP:0012437)2.05984571
9711 pairs of ribs (HP:0000878)2.03968912
98Entropion (HP:0000621)2.03382115
99Gastrointestinal carcinoma (HP:0002672)2.02527258
100Malignant gastrointestinal tract tumors (HP:0006749)2.02527258
101Spastic diplegia (HP:0001264)2.02068255
102Ectopic kidney (HP:0000086)2.01878435
103Neoplasm of the oral cavity (HP:0100649)2.01362373
104Meningitis (HP:0001287)2.00557238
105Increased density of long bones (HP:0006392)2.00047982
106Glioma (HP:0009733)1.99267024
107Conjunctival telangiectasia (HP:0000524)1.99037392
108Emphysema (HP:0002097)1.98003604
109Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.97995696
110Hepatocellular carcinoma (HP:0001402)1.97947246
111Recurrent viral infections (HP:0004429)1.97359825
112Proximal placement of thumb (HP:0009623)1.97176355
113Onycholysis (HP:0001806)1.96146131
114Carpal bone hypoplasia (HP:0001498)1.94548380
115Papillary thyroid carcinoma (HP:0002895)1.94488863
116Cutaneous photosensitivity (HP:0000992)1.94190839
117Poikiloderma (HP:0001029)1.93831295
118Biliary tract neoplasm (HP:0100574)1.93606803
119Panhypogammaglobulinemia (HP:0003139)1.93536443
120Central scotoma (HP:0000603)1.93062307
121Osteomyelitis (HP:0002754)1.92581450
122Hypoplasia of the capital femoral epiphysis (HP:0003090)1.91141969
123Abnormality of the carotid arteries (HP:0005344)1.90459937
124Macrocytic anemia (HP:0001972)1.90065725
125Orthostatic hypotension (HP:0001278)1.89561143
126Pallor (HP:0000980)1.89512286
127Neoplasm of striated muscle (HP:0009728)1.89167128
128Pancreatic islet-cell hyperplasia (HP:0004510)1.88905546
129Heterotopia (HP:0002282)1.87815826
130Abnormality of B cell number (HP:0010975)1.87586020
131Cellulitis (HP:0100658)1.85667267
132Prostate neoplasm (HP:0100787)1.84665704
133Abnormality of the duodenum (HP:0002246)1.81838382
134Abnormality of T cell physiology (HP:0011840)1.80982237
135Abnormality of pyrimidine metabolism (HP:0004353)1.80283440
136Paralysis (HP:0003470)1.79912597
137Abnormality of the calcaneus (HP:0008364)1.79866929
138Osteomalacia (HP:0002749)1.79550721
139Absent thumb (HP:0009777)1.79061673
140Abnormal number of incisors (HP:0011064)1.77884984
141Bronchitis (HP:0012387)1.77776651
142Neoplasm of the colon (HP:0100273)1.74971696
143Gingival bleeding (HP:0000225)1.74459920
144Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.74402872
145Recurrent pneumonia (HP:0006532)1.74327044
146Acute lymphatic leukemia (HP:0006721)1.74285680
147Abnormality of the vasculature of the conjunctiva (HP:0008054)1.73895757
148Missing ribs (HP:0000921)1.73452449
149Long eyelashes (HP:0000527)1.72823855
150Ovarian neoplasm (HP:0100615)1.72455608
151Truncal obesity (HP:0001956)1.71287159
152Abnormal auditory evoked potentials (HP:0006958)1.70868599
153T lymphocytopenia (HP:0005403)1.69123272
154Atresia of the external auditory canal (HP:0000413)1.68939181
155Short thumb (HP:0009778)1.68414395
156Hyperalaninemia (HP:0003348)1.68378920
157Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68378920
158Abnormality of alanine metabolism (HP:0010916)1.68378920
159Breast hypoplasia (HP:0003187)1.68367916
160Abnormal platelet volume (HP:0011876)1.68237224
161Recurrent lower respiratory tract infections (HP:0002783)1.67673803
162Thrombocytosis (HP:0001894)1.66717194
163Amaurosis fugax (HP:0100576)1.66381760
164Deep philtrum (HP:0002002)1.66332929
165Patellar aplasia (HP:0006443)1.65802447
166Abnormality of the peritoneum (HP:0002585)1.65462752
167Cutis marmorata (HP:0000965)1.65422006
168Duplicated collecting system (HP:0000081)1.65125309

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.05383451
2ZAK6.15112308
3STK43.51306841
4CDC73.39313254
5VRK13.36835237
6RPS6KA52.82792728
7EEF2K2.36505930
8MAP3K102.11570581
9NEK22.00123047
10SCYL21.98943008
11PKN21.97547395
12CDK121.92551093
13CDK91.91611875
14WEE11.91531145
15TAF11.78232649
16MAP3K81.77651481
17MST41.77476266
18AURKB1.72543964
19PIM11.65666915
20SMG11.59213875
21CHEK21.50256693
22EIF2AK11.47384868
23BUB11.46365891
24RPS6KB21.45981851
25SRPK11.32983769
26TTK1.26743342
27GRK61.14446577
28PBK1.11284820
29BTK1.09163161
30ATR1.08366686
31TTN1.02681272
32DYRK31.00645380
33STK101.00435520
34FLT30.97972411
35PLK10.97694567
36CDK40.94082053
37DAPK30.92697489
38AURKA0.92569712
39NEK10.91772990
40PKN10.87215667
41MST1R0.84193088
42PASK0.83222547
43CAMK1D0.83084267
44CHEK10.76272766
45CDK60.76183849
46PLK30.75000676
47ATM0.74534437
48TEC0.71575301
49NME20.70506208
50MELK0.70253651
51BRAF0.67772881
52NUAK10.67575641
53STK30.67083658
54VRK20.66293840
55CDK70.61671879
56PIM20.61420650
57CDK20.61185929
58RIPK40.59571070
59CDK190.57904231
60TRIB30.57869715
61LRRK20.57221786
62FRK0.57155156
63NLK0.57140281
64PRKAA10.55840118
65BRSK20.55381597
66MET0.55119345
67DYRK1B0.54497668
68AKT20.54147576
69ACVR1B0.53098186
70BMX0.52177139
71TRPM70.50783708
72LATS10.50503031
73CDK10.48672571
74MARK30.48574409
75CCNB10.47442904
76PIK3CG0.47361267
77CSNK1D0.46261947
78EIF2AK30.45625137
79STK240.44567836
80EPHA20.43975271
81NEK90.41992858
82BRSK10.41394507
83TGFBR10.41105025
84BMPR20.40293364
85MKNK20.38927351
86FGFR20.38655449
87JAK20.37627893
88BRD40.37189911
89RAF10.33958560
90ALK0.33498053
91TSSK60.33034693
92BLK0.32257998
93PRKDC0.31192829
94MTOR0.29597332
95EIF2AK20.28949196
96PDGFRA0.28885351
97PAK40.28697345
98IRAK40.28428177
99PTK60.28395493
100RPS6KB10.26799431
101MAP4K10.26494858
102CSNK1G10.25963736
103PLK40.25633237
104MAPKAPK50.25512013
105TESK20.24817914
106CLK10.24386154
107MAPK140.24369157
108PAK10.24326384
109EPHA30.24273432
110PRKCQ0.23409032
111ARAF0.22500036
112IKBKB0.22430181
113FGR0.22175492
114MAPKAPK30.22083986
115CSNK1G30.22081009
116AKT10.21537152
117MAPK110.21458884
118BMPR1B0.21313207
119RPS6KA40.21215746
120MKNK10.20561478
121PRKCD0.19999338
122PAK20.19598608
123KSR10.19247327
124CSNK2A20.18919264
125FGFR30.16091586
126LYN0.15804914
127GRK50.15577733
128SGK10.14946804
129CSF1R0.14578187
130CAMK1G0.13307011
131SYK0.13209153
132CSNK1A1L0.12808031
133RPS6KA30.12301873
134RPS6KC10.12266900
135PRKCB0.12237425
136HCK0.08544988
137ILK0.08293564
138DYRK20.07861749
139STK160.06944087
140FGFR40.04292674

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.40779160
2* Viral carcinogenesis_Homo sapiens_hsa052033.30157251
3DNA replication_Homo sapiens_hsa030302.91334001
4Mismatch repair_Homo sapiens_hsa034302.41675300
5Cell cycle_Homo sapiens_hsa041102.08513601
6One carbon pool by folate_Homo sapiens_hsa006702.04098631
7* Systemic lupus erythematosus_Homo sapiens_hsa0532211.3456525
8Transcriptional misregulation in cancer_Homo sapiens_hsa052021.87675120
9Non-homologous end-joining_Homo sapiens_hsa034501.66557022
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56951179
11Base excision repair_Homo sapiens_hsa034101.54720750
12RNA transport_Homo sapiens_hsa030131.49487608
13Fanconi anemia pathway_Homo sapiens_hsa034601.47762859
14Nucleotide excision repair_Homo sapiens_hsa034201.47323739
15Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.41912009
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38520823
17Homologous recombination_Homo sapiens_hsa034401.38149565
18Spliceosome_Homo sapiens_hsa030401.22553908
19Ribosome_Homo sapiens_hsa030101.16535718
20Allograft rejection_Homo sapiens_hsa053301.12989483
21p53 signaling pathway_Homo sapiens_hsa041151.10802224
22Autoimmune thyroid disease_Homo sapiens_hsa053201.05981413
23Asthma_Homo sapiens_hsa053101.03618681
24MicroRNAs in cancer_Homo sapiens_hsa052060.95936265
25Graft-versus-host disease_Homo sapiens_hsa053320.94444601
26mRNA surveillance pathway_Homo sapiens_hsa030150.90816561
27Small cell lung cancer_Homo sapiens_hsa052220.89514593
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78218211
29Chronic myeloid leukemia_Homo sapiens_hsa052200.76430844
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73549755
31Selenocompound metabolism_Homo sapiens_hsa004500.71850639
32Type I diabetes mellitus_Homo sapiens_hsa049400.70743366
33Pyrimidine metabolism_Homo sapiens_hsa002400.70666140
34Non-small cell lung cancer_Homo sapiens_hsa052230.69900371
35RNA degradation_Homo sapiens_hsa030180.65642684
36HTLV-I infection_Homo sapiens_hsa051660.63382015
37Herpes simplex infection_Homo sapiens_hsa051680.61999514
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61771032
39Oocyte meiosis_Homo sapiens_hsa041140.60786670
40Apoptosis_Homo sapiens_hsa042100.53135916
41Antigen processing and presentation_Homo sapiens_hsa046120.52694846
42Epstein-Barr virus infection_Homo sapiens_hsa051690.51211695
43Hepatitis B_Homo sapiens_hsa051610.50856464
44Bladder cancer_Homo sapiens_hsa052190.47966004
45Central carbon metabolism in cancer_Homo sapiens_hsa052300.47456348
46Hematopoietic cell lineage_Homo sapiens_hsa046400.45688135
47mTOR signaling pathway_Homo sapiens_hsa041500.44906254
48Pancreatic cancer_Homo sapiens_hsa052120.43732088
49Vitamin B6 metabolism_Homo sapiens_hsa007500.41401813
50Glioma_Homo sapiens_hsa052140.41163806
51Measles_Homo sapiens_hsa051620.40737256
52NF-kappa B signaling pathway_Homo sapiens_hsa040640.39820160
53B cell receptor signaling pathway_Homo sapiens_hsa046620.39800405
54Malaria_Homo sapiens_hsa051440.38991470
55Prostate cancer_Homo sapiens_hsa052150.38436480
56Lysine degradation_Homo sapiens_hsa003100.37202945
57RNA polymerase_Homo sapiens_hsa030200.36952296
58Colorectal cancer_Homo sapiens_hsa052100.36321495
59Melanoma_Homo sapiens_hsa052180.33314949
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33195862
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33158435
62Biosynthesis of amino acids_Homo sapiens_hsa012300.32377463
63Proteoglycans in cancer_Homo sapiens_hsa052050.32149026
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31731744
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31303208
66Renin-angiotensin system_Homo sapiens_hsa046140.30211989
67FoxO signaling pathway_Homo sapiens_hsa040680.30047583
68Thyroid cancer_Homo sapiens_hsa052160.28507497
69Legionellosis_Homo sapiens_hsa051340.28216257
70Pentose phosphate pathway_Homo sapiens_hsa000300.27254108
71Proteasome_Homo sapiens_hsa030500.27221086
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26629347
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25124878
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24370515
75HIF-1 signaling pathway_Homo sapiens_hsa040660.23125817
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.22521457
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21862170
78Adherens junction_Homo sapiens_hsa045200.21659933
79Viral myocarditis_Homo sapiens_hsa054160.21587955
80Influenza A_Homo sapiens_hsa051640.20744638
81Basal transcription factors_Homo sapiens_hsa030220.20515246
82Endometrial cancer_Homo sapiens_hsa052130.20240448
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20212688
84Carbon metabolism_Homo sapiens_hsa012000.19581027
85TGF-beta signaling pathway_Homo sapiens_hsa043500.19497055
86Purine metabolism_Homo sapiens_hsa002300.19398508
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19018578
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18474536
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.18193809
90Leishmaniasis_Homo sapiens_hsa051400.17814152
91Pathways in cancer_Homo sapiens_hsa052000.17773871
92Sulfur relay system_Homo sapiens_hsa041220.17345363
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.16341342
94Focal adhesion_Homo sapiens_hsa045100.16018514
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15542553
96Glutathione metabolism_Homo sapiens_hsa004800.15444028
97Toxoplasmosis_Homo sapiens_hsa051450.15440582
98Galactose metabolism_Homo sapiens_hsa000520.15279429
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.15014817
100Platelet activation_Homo sapiens_hsa046110.15006712
101Notch signaling pathway_Homo sapiens_hsa043300.14564960
102Inositol phosphate metabolism_Homo sapiens_hsa005620.14455500
103Primary immunodeficiency_Homo sapiens_hsa053400.14358524
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.13150834
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.12441849
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.12249324
107Osteoclast differentiation_Homo sapiens_hsa043800.12109397
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.10392106
109AMPK signaling pathway_Homo sapiens_hsa041520.10339564
110Shigellosis_Homo sapiens_hsa051310.10186992
111Nitrogen metabolism_Homo sapiens_hsa009100.09969964
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09481250
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09438631
114Fructose and mannose metabolism_Homo sapiens_hsa000510.09188198
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.08798928
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.08231951
117Steroid biosynthesis_Homo sapiens_hsa001000.07250759
118Staphylococcus aureus infection_Homo sapiens_hsa051500.06225359
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.05626857
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.05580175
121Hippo signaling pathway_Homo sapiens_hsa043900.05138489
122Pyruvate metabolism_Homo sapiens_hsa006200.05046865
123Chemokine signaling pathway_Homo sapiens_hsa040620.04941712
124Basal cell carcinoma_Homo sapiens_hsa052170.04793637
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.04364700
126Acute myeloid leukemia_Homo sapiens_hsa052210.04113941
127ECM-receptor interaction_Homo sapiens_hsa045120.04065327
128Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.03685889

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