HIST1H2BJ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)8.79249497
2DNA replication-dependent nucleosome assembly (GO:0006335)8.08448773
3DNA replication-dependent nucleosome organization (GO:0034723)8.08448773
4protoporphyrinogen IX biosynthetic process (GO:0006782)7.82941664
5* mucosal immune response (GO:0002385)7.62907420
6chromatin assembly (GO:0031497)7.29535763
7* nucleosome assembly (GO:0006334)7.08508769
8* organ or tissue specific immune response (GO:0002251)6.86210918
9* nucleosome organization (GO:0034728)6.13670401
10regulation of histone H3-K9 methylation (GO:0051570)6.04839584
11* protein-DNA complex assembly (GO:0065004)5.99383284
12mitotic chromosome condensation (GO:0007076)5.86259121
13porphyrin-containing compound biosynthetic process (GO:0006779)5.71192248
14chromatin assembly or disassembly (GO:0006333)5.60583685
15erythrocyte maturation (GO:0043249)5.53023644
16protein localization to kinetochore (GO:0034501)5.51865338
17sister chromatid segregation (GO:0000819)5.44069766
18* protein-DNA complex subunit organization (GO:0071824)5.37196370
19DNA unwinding involved in DNA replication (GO:0006268)5.27844030
20heme biosynthetic process (GO:0006783)5.24223597
21mitotic sister chromatid segregation (GO:0000070)5.21799209
22nuclear pore complex assembly (GO:0051292)5.06185500
23protein localization to chromosome, centromeric region (GO:0071459)5.05655543
24negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)5.01071758
25nuclear pore organization (GO:0006999)5.01046822
26tetrapyrrole biosynthetic process (GO:0033014)4.99691074
27regulation of response to osmotic stress (GO:0047484)4.78164131
28hemoglobin metabolic process (GO:0020027)4.72529057
29regulation of DNA endoreduplication (GO:0032875)4.60743070
30microtubule depolymerization (GO:0007019)4.60532169
31kinetochore organization (GO:0051383)4.38558673
32positive regulation of mitotic sister chromatid separation (GO:1901970)4.37489366
33positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.37489366
34positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.37489366
35DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.32867501
36erythrocyte development (GO:0048821)4.30932528
37DNA replication initiation (GO:0006270)4.28739846
38* antibacterial humoral response (GO:0019731)4.24060499
39porphyrin-containing compound metabolic process (GO:0006778)4.21915768
40CENP-A containing nucleosome assembly (GO:0034080)4.21369878
41positive regulation of chromosome segregation (GO:0051984)4.18929293
42chromatin remodeling at centromere (GO:0031055)4.17861342
43regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.14675709
44meiotic chromosome segregation (GO:0045132)4.14547920
45attachment of spindle microtubules to kinetochore (GO:0008608)4.05763863
46regulation of centriole replication (GO:0046599)4.04488053
47regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.01474784
48DNA strand elongation involved in DNA replication (GO:0006271)3.98219625
49* innate immune response in mucosa (GO:0002227)3.95550926
50* antimicrobial humoral response (GO:0019730)3.92859797
51DNA replication-independent nucleosome assembly (GO:0006336)3.90128253
52DNA replication-independent nucleosome organization (GO:0034724)3.90128253
53DNA damage response, signal transduction resulting in transcription (GO:0042772)3.86963674
54pore complex assembly (GO:0046931)3.85916455
55folic acid-containing compound biosynthetic process (GO:0009396)3.85219325
56mitotic nuclear envelope disassembly (GO:0007077)3.84876870
57regulation of megakaryocyte differentiation (GO:0045652)3.82097602
58protein K6-linked ubiquitination (GO:0085020)3.81850183
59viral mRNA export from host cell nucleus (GO:0046784)3.80889572
60chromosome condensation (GO:0030261)3.80774334
61DNA strand elongation (GO:0022616)3.80617852
62heme metabolic process (GO:0042168)3.79960620
63telomere maintenance via semi-conservative replication (GO:0032201)3.79800805
64regulation of translational fidelity (GO:0006450)3.79635335
65regulation of centrosome cycle (GO:0046605)3.74873799
66regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.71764154
67mitotic recombination (GO:0006312)3.67427631
68DNA duplex unwinding (GO:0032508)3.65256500
69mitotic sister chromatid cohesion (GO:0007064)3.65190319
70DNA geometric change (GO:0032392)3.64705717
71regulation of gene silencing (GO:0060968)3.64019502
72nuclear envelope disassembly (GO:0051081)3.62539574
73membrane disassembly (GO:0030397)3.62539574
74regulation of sister chromatid cohesion (GO:0007063)3.59982648
75protein localization to chromosome (GO:0034502)3.57378644
76negative regulation of histone methylation (GO:0031061)3.54737069
77regulation of centrosome duplication (GO:0010824)3.52289170
78response to methylmercury (GO:0051597)3.50887990
79mitotic metaphase plate congression (GO:0007080)3.49182399
80DNA replication checkpoint (GO:0000076)3.46796781
81histone exchange (GO:0043486)3.45132007
82proline biosynthetic process (GO:0006561)3.43744091
83chromosome segregation (GO:0007059)3.42304534
84telomere maintenance via recombination (GO:0000722)3.42072041
85regulation of spindle organization (GO:0090224)3.41713444
86dosage compensation (GO:0007549)3.37233098
87DNA synthesis involved in DNA repair (GO:0000731)3.37120513
88DNA topological change (GO:0006265)3.36228477
89metaphase plate congression (GO:0051310)3.34881002
90response to insecticide (GO:0017085)3.31209872
91nucleobase-containing small molecule interconversion (GO:0015949)3.30659270
92IMP biosynthetic process (GO:0006188)3.27858409
93mitochondrial DNA metabolic process (GO:0032042)3.27330851
94DNA packaging (GO:0006323)3.25310312
95translesion synthesis (GO:0019985)3.25253834
96establishment of chromosome localization (GO:0051303)3.23823909
97DNA conformation change (GO:0071103)3.22690146
98regulation of chromosome segregation (GO:0051983)3.21063000
99kinetochore assembly (GO:0051382)3.19149669
100telomere organization (GO:0032200)3.18731089
101erythrocyte differentiation (GO:0030218)3.17172417
102postreplication repair (GO:0006301)3.15461389
103telomere maintenance via telomere lengthening (GO:0010833)3.15422641
104regulation of mitotic spindle organization (GO:0060236)3.12475787
105positive regulation of histone methylation (GO:0031062)3.10535595
106rRNA transcription (GO:0009303)3.09800241
107nucleotide-excision repair, DNA gap filling (GO:0006297)3.09320768
108regulation of mitotic metaphase/anaphase transition (GO:0030071)3.07612018
109response to lead ion (GO:0010288)3.06516695
110somatic hypermutation of immunoglobulin genes (GO:0016446)3.05719236
111somatic diversification of immune receptors via somatic mutation (GO:0002566)3.05719236
112spindle checkpoint (GO:0031577)3.01630774
113non-recombinational repair (GO:0000726)3.01394720
114double-strand break repair via nonhomologous end joining (GO:0006303)3.01394720
115protein complex localization (GO:0031503)2.99630727
116telomere maintenance (GO:0000723)2.99192110
117regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.99132461
118negative regulation of chromosome segregation (GO:0051985)2.97795108
119regulation of mammary gland epithelial cell proliferation (GO:0033599)2.97537694
120cellular protein complex localization (GO:0034629)2.95005079
121* defense response to Gram-positive bacterium (GO:0050830)2.87200147
122peptidyl-arginine omega-N-methylation (GO:0035247)2.86214128
123ribosomal small subunit biogenesis (GO:0042274)2.84407531
124maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.83523051
125histone phosphorylation (GO:0016572)2.82007167
126mitotic spindle assembly checkpoint (GO:0007094)2.78169186
127peptidyl-lysine dimethylation (GO:0018027)2.77675606
128regulation of mitotic sister chromatid separation (GO:0010965)2.76656331
129regulation of mitotic sister chromatid segregation (GO:0033047)2.76656331
130regulation of sister chromatid segregation (GO:0033045)2.76656331
131ATP-dependent chromatin remodeling (GO:0043044)2.76547995
132regulation of spindle checkpoint (GO:0090231)2.76088112
133deoxyribonucleotide biosynthetic process (GO:0009263)2.74041585
134spindle assembly checkpoint (GO:0071173)2.73682865
135negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.73253958
136negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.73253958
137negative regulation of mitotic sister chromatid segregation (GO:0033048)2.73253958
138negative regulation of mitotic sister chromatid separation (GO:2000816)2.73253958
139negative regulation of sister chromatid segregation (GO:0033046)2.73253958

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.38074923
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.49013537
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.37356767
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.95072085
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.97900763
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94428921
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.86273446
8* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.73766187
9* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.35501577
10* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.21756633
11* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18800042
12TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.17742465
13* E2F1_21310950_ChIP-Seq_MCF-7_Human2.17021149
14* SOX2_16153702_ChIP-ChIP_HESCs_Human2.01599495
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse14.1189214
16NELFA_20434984_ChIP-Seq_ESCs_Mouse1.88325828
17MYC_18555785_ChIP-Seq_MESCs_Mouse1.79302647
18* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.75758206
19MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70372460
20GATA1_22025678_ChIP-Seq_K562_Human1.68755569
21AR_21909140_ChIP-Seq_LNCAP_Human1.66951252
22ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56172482
23POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48601348
24* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48540849
25IRF1_19129219_ChIP-ChIP_H3396_Human1.48359768
26ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48350299
27HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.47542787
28* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46050420
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.44821648
30HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43678073
31* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.40403695
32SOX2_18555785_ChIP-Seq_MESCs_Mouse1.39332774
33* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39223643
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38441159
35* VDR_23849224_ChIP-Seq_CD4+_Human1.38213777
36* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.35414724
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33609692
38GATA1_19941826_ChIP-Seq_K562_Human1.32471976
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30350771
40* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26959919
41MYC_22102868_ChIP-Seq_BL_Human1.25687693
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24208109
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22005283
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21738106
45KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21129379
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16931746
47ELK1_19687146_ChIP-ChIP_HELA_Human1.11552019
48* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08996276
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07045971
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05969329
51* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04751637
52NANOG_16153702_ChIP-ChIP_HESCs_Human1.03889525
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03422653
54* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.02370094
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02211497
56DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01439023
57* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99583589
58ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98936834
59E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98746032
60CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98503519
61KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.98048070
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97658541
63MYC_18940864_ChIP-ChIP_HL60_Human0.97352537
64GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96632202
65NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96586630
66VDR_21846776_ChIP-Seq_THP-1_Human0.96556120
67SCL_19346495_ChIP-Seq_HPC-7_Human0.96087101
68KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.93579509
69GATA1_19941827_ChIP-Seq_MEL_Mouse0.92884637
70PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91163217
71FOXP3_21729870_ChIP-Seq_TREG_Human0.90958859
72XRN2_22483619_ChIP-Seq_HELA_Human0.90188861
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88525390
74GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86864189
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86393088
76* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.84575089
77CREB1_15753290_ChIP-ChIP_HEK293T_Human0.83856581
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.83781296
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.83457262
80* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82970921
81MYCN_18555785_ChIP-Seq_MESCs_Mouse0.82122782
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82075624
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82058947
84EST1_17652178_ChIP-ChIP_JURKAT_Human0.81785288
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.81557213
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.80209965
87TTF2_22483619_ChIP-Seq_HELA_Human0.78678517
88CIITA_25753668_ChIP-Seq_RAJI_Human0.77994108
89MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.77965393
90* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.77256439
91HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.76765861
92PKCTHETA_26484144_Chip-Seq_BREAST_Human0.76003452
93NOTCH1_21737748_ChIP-Seq_TLL_Human0.75804924
94CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75039344
95ZFX_18555785_ChIP-Seq_MESCs_Mouse0.73873307
96* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.73695151
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.69879891
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.69258458
99KDM5A_27292631_Chip-Seq_BREAST_Human0.68807332
100NANOG_21062744_ChIP-ChIP_HESCs_Human0.68595003
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.68104531
102GABP_19822575_ChIP-Seq_HepG2_Human0.67765001
103PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.67002003
104MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.66340755
105GABP_17652178_ChIP-ChIP_JURKAT_Human0.65523887
106UTX_26944678_Chip-Seq_JUKART_Human0.65386632
107SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.65191809
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.64897985
109ETS1_20019798_ChIP-Seq_JURKAT_Human0.64596255
110FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.64383872
111DCP1A_22483619_ChIP-Seq_HELA_Human0.62522422
112ZNF263_19887448_ChIP-Seq_K562_Human0.61762534
113HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.61631770
114RUNX1_22412390_ChIP-Seq_EML_Mouse0.61617907
115* MAF_26560356_Chip-Seq_TH1_Human0.61579434
116RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.61248753
117GATA2_19941826_ChIP-Seq_K562_Human0.61003113
118NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.59624216

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo6.26327093
2MP0004147_increased_porphyrin_level5.72510271
3MP0010094_abnormal_chromosome_stability4.97376659
4MP0003111_abnormal_nucleus_morphology4.68684147
5MP0003077_abnormal_cell_cycle3.96297371
6MP0003693_abnormal_embryo_hatching3.66579559
7MP0010307_abnormal_tumor_latency3.62715674
8MP0008057_abnormal_DNA_replication3.15570987
9MP0004957_abnormal_blastocyst_morpholog3.11574051
10MP0010352_gastrointestinal_tract_polyps2.63837319
11MP0008058_abnormal_DNA_repair2.48223704
12MP0005464_abnormal_platelet_physiology2.48195627
13MP0009697_abnormal_copulation2.44812792
14MP0000350_abnormal_cell_proliferation2.32954699
15MP0001661_extended_life_span2.28524027
16MP0005076_abnormal_cell_differentiation2.10612179
17MP0008007_abnormal_cellular_replicative2.00612869
18MP0001730_embryonic_growth_arrest1.99196614
19MP0008877_abnormal_DNA_methylation1.98704758
20MP0005083_abnormal_biliary_tract1.97843363
21MP0002396_abnormal_hematopoietic_system1.96663657
22MP0004808_abnormal_hematopoietic_stem1.91863743
23MP0008932_abnormal_embryonic_tissue1.87547035
24MP0003705_abnormal_hypodermis_morpholog1.87078670
25MP0000490_abnormal_crypts_of1.85541969
26MP0003763_abnormal_thymus_physiology1.84600656
27MP0006054_spinal_hemorrhage1.74779546
28MP0004185_abnormal_adipocyte_glucose1.73195088
29MP0006035_abnormal_mitochondrial_morpho1.66579700
30MP0002019_abnormal_tumor_incidence1.65976365
31MP0001697_abnormal_embryo_size1.55636661
32MP0002086_abnormal_extraembryonic_tissu1.55365494
33MP0002398_abnormal_bone_marrow1.52583078
34MP0004197_abnormal_fetal_growth/weight/1.50736595
35MP0005380_embryogenesis_phenotype1.49120509
36MP0001672_abnormal_embryogenesis/_devel1.49120509
37MP0001545_abnormal_hematopoietic_system1.46650304
38MP0005397_hematopoietic_system_phenotyp1.46650304
39MP0002080_prenatal_lethality1.45559282
40MP0003121_genomic_imprinting1.44721369
41MP0000313_abnormal_cell_death1.42901019
42MP0002166_altered_tumor_susceptibility1.42406320
43MP0003123_paternal_imprinting1.41474929
44MP0000703_abnormal_thymus_morphology1.41349922
45MP0002009_preneoplasia1.39088316
46MP0002722_abnormal_immune_system1.39027469
47MP0005645_abnormal_hypothalamus_physiol1.33987514
48MP0003718_maternal_effect1.33299990
49MP0000465_gastrointestinal_hemorrhage1.31833742
50MP0003984_embryonic_growth_retardation1.31624696
51MP0002084_abnormal_developmental_patter1.31590618
52MP0000689_abnormal_spleen_morphology1.30838444
53MP0002088_abnormal_embryonic_growth/wei1.29407814
54MP0003787_abnormal_imprinting1.29094906
55MP0002085_abnormal_embryonic_tissue1.27359332
56MP0002877_abnormal_melanocyte_morpholog1.20156697
57MP0003786_premature_aging1.17270749
58MP0001835_abnormal_antigen_presentation1.16723506
59MP0002006_tumorigenesis1.16406675
60MP0008770_decreased_survivor_rate1.13334704
61MP0000015_abnormal_ear_pigmentation1.13179885
62MP0010234_abnormal_vibrissa_follicle1.12733910
63MP0002429_abnormal_blood_cell1.10703779
64MP0003300_gastrointestinal_ulcer1.09578090
65MP0005623_abnormal_meninges_morphology1.06741340
66MP0002163_abnormal_gland_morphology1.05789082
67MP0005501_abnormal_skin_physiology1.00357803
68MP0002095_abnormal_skin_pigmentation0.98109027
69MP0005220_abnormal_exocrine_pancreas0.97743868
70MP0009672_abnormal_birth_weight0.96292703
71MP0005451_abnormal_body_composition0.94313494
72MP0000685_abnormal_immune_system0.93389823
73MP0009703_decreased_birth_body0.91879643
74MP0005621_abnormal_cell_physiology0.89596010
75MP0001727_abnormal_embryo_implantation0.89152169
76MP0004233_abnormal_muscle_weight0.88683447
77MP0005384_cellular_phenotype0.85298750
78MP0003567_abnormal_fetal_cardiomyocyte0.83544675
79MP0002160_abnormal_reproductive_system0.83537675
80MP0000716_abnormal_immune_system0.82322694
81MP0003890_abnormal_embryonic-extraembry0.78659586
82MP0001915_intracranial_hemorrhage0.78343119
83MP0009053_abnormal_anal_canal0.78004713
84MP0003937_abnormal_limbs/digits/tail_de0.77676031
85MP0002111_abnormal_tail_morphology0.76515837
86MP0003453_abnormal_keratinocyte_physiol0.76154489
87MP0003303_peritoneal_inflammation0.75426979
88MP0005171_absent_coat_pigmentation0.74593776
89MP0001800_abnormal_humoral_immune0.74322271
90MP0001346_abnormal_lacrimal_gland0.73833621
91MP0009931_abnormal_skin_appearance0.72947767
92MP0000733_abnormal_muscle_development0.70919512
93MP0008995_early_reproductive_senescence0.70683111
94MP0003806_abnormal_nucleotide_metabolis0.70642497
95MP0008260_abnormal_autophagy0.69989182
96MP0003566_abnormal_cell_adhesion0.69847141
97MP0002092_abnormal_eye_morphology0.69763962
98MP0001293_anophthalmia0.67885214
99MP0005187_abnormal_penis_morphology0.67280940
100MP0003699_abnormal_female_reproductive0.66507447
101MP0003448_altered_tumor_morphology0.65446156
102MP0000003_abnormal_adipose_tissue0.64272779
103MP0002925_abnormal_cardiovascular_devel0.63851385
104MP0009278_abnormal_bone_marrow0.62869622
105MP0001849_ear_inflammation0.62443885
106MP0005000_abnormal_immune_tolerance0.62158128
107MP0000537_abnormal_urethra_morphology0.61712210
108MP0001929_abnormal_gametogenesis0.61516933
109MP0005310_abnormal_salivary_gland0.60939279
110MP0001879_abnormal_lymphatic_vessel0.60532485
111MP0000858_altered_metastatic_potential0.60493691
112MP0002210_abnormal_sex_determination0.59366465
113MP0002697_abnormal_eye_size0.59252862
114MP0009765_abnormal_xenobiotic_induced0.59193127
115MP0000428_abnormal_craniofacial_morphol0.59110048
116MP0001191_abnormal_skin_condition0.58982218
117MP0009333_abnormal_splenocyte_physiolog0.58674773
118MP0000358_abnormal_cell_content/0.58425796
119MP0000266_abnormal_heart_morphology0.57984065
120MP0002420_abnormal_adaptive_immunity0.57614781
121MP0000013_abnormal_adipose_tissue0.57539575
122MP0000477_abnormal_intestine_morphology0.56816142
123MP0003221_abnormal_cardiomyocyte_apopto0.56567793
124MP0000372_irregular_coat_pigmentation0.56092532
125MP0001216_abnormal_epidermal_layer0.56003749
126MP0001145_abnormal_male_reproductive0.55687356
127MP0001819_abnormal_immune_cell0.55602460
128MP0002452_abnormal_antigen_presenting0.55070446
129MP0005023_abnormal_wound_healing0.54875761
130MP0004947_skin_inflammation0.54358158
131MP0004264_abnormal_extraembryonic_tissu0.53366000
132MP0005671_abnormal_response_to0.51604403
133MP0001243_abnormal_dermal_layer0.50766675
134MP0003186_abnormal_redox_activity0.49752417

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)9.27472367
2Hypochromic microcytic anemia (HP:0004840)7.47850396
3Abnormality of the heme biosynthetic pathway (HP:0010472)7.01987247
4Acanthocytosis (HP:0001927)5.51310034
5IgA deficiency (HP:0002720)4.77871975
6Reticulocytosis (HP:0001923)4.56414825
7IgM deficiency (HP:0002850)4.45193637
8Cholelithiasis (HP:0001081)4.26658778
9Abnormality of reticulocytes (HP:0004312)4.11597243
10Chromsome breakage (HP:0040012)4.01100650
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.86477100
12Abnormal gallbladder morphology (HP:0012437)3.72994650
13Colitis (HP:0002583)3.67802417
14Hypochromic anemia (HP:0001931)3.66000039
15Birth length less than 3rd percentile (HP:0003561)3.65810171
16Increased mean platelet volume (HP:0011877)3.63193190
17Abnormal platelet volume (HP:0011876)3.46237148
18Abnormality of chromosome stability (HP:0003220)3.43257171
19Insomnia (HP:0100785)3.42186254
20Diaphragmatic weakness (HP:0009113)3.33461778
21Reticulocytopenia (HP:0001896)3.31921542
22Petechiae (HP:0000967)3.18615871
23Volvulus (HP:0002580)3.09672418
24Impulsivity (HP:0100710)3.03836073
25Cutaneous photosensitivity (HP:0000992)2.86526340
26High pitched voice (HP:0001620)2.84031341
27Cutaneous melanoma (HP:0012056)2.80943827
28Paralysis (HP:0003470)2.73281721
29Basal cell carcinoma (HP:0002671)2.72409022
30Microvesicular hepatic steatosis (HP:0001414)2.70746776
31Prolonged bleeding time (HP:0003010)2.70175856
32Microcytic anemia (HP:0001935)2.66199645
33Cafe-au-lait spot (HP:0000957)2.63658751
34Abnormality of the fingertips (HP:0001211)2.60380245
35Prominent nose (HP:0000448)2.60157685
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.58399397
37Small intestinal stenosis (HP:0012848)2.57770603
38Duodenal stenosis (HP:0100867)2.57770603
39Osteomalacia (HP:0002749)2.55090422
40Gastrointestinal stroma tumor (HP:0100723)2.51571694
41Aplasia/Hypoplasia of the sacrum (HP:0008517)2.51229873
42Abnormality of cells of the erythroid lineage (HP:0012130)2.50313490
43Abnormality of the gallbladder (HP:0005264)2.50153167
44Menorrhagia (HP:0000132)2.48019540
45Medulloblastoma (HP:0002885)2.46719781
46Hyperbilirubinemia (HP:0002904)2.46506104
47Meckel diverticulum (HP:0002245)2.46159008
48Orthostatic hypotension (HP:0001278)2.44747544
49Abnormality of the labia minora (HP:0012880)2.41254220
50Abnormality of the preputium (HP:0100587)2.41093666
51Ependymoma (HP:0002888)2.38775328
52Abnormality of the ileum (HP:0001549)2.33929265
53Squamous cell carcinoma (HP:0002860)2.31648875
54Ankyloglossia (HP:0010296)2.31529845
55Short 4th metacarpal (HP:0010044)2.30356320
56Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.30356320
57Abnormality of pyrimidine metabolism (HP:0004353)2.30247706
58Progressive external ophthalmoplegia (HP:0000590)2.29675013
59Myelodysplasia (HP:0002863)2.28658835
60Dyschromatopsia (HP:0007641)2.28367494
61Papilloma (HP:0012740)2.25332875
62Verrucae (HP:0200043)2.25332875
63Abnormality of DNA repair (HP:0003254)2.24751503
64Patellar aplasia (HP:0006443)2.24340500
65Abnormal number of erythroid precursors (HP:0012131)2.23504856
66Selective tooth agenesis (HP:0001592)2.23433855
67Inflammation of the large intestine (HP:0002037)2.21603095
68Ureteral duplication (HP:0000073)2.21436193
69Increased nuchal translucency (HP:0010880)2.20735466
70Rhabdomyosarcoma (HP:0002859)2.18886600
71Sandal gap (HP:0001852)2.18692777
72Hypergonadotropic hypogonadism (HP:0000815)2.18493885
73Abnormal platelet function (HP:0011869)2.17938348
74Impaired platelet aggregation (HP:0003540)2.17938348
75Sloping forehead (HP:0000340)2.16567380
76Leiomyosarcoma (HP:0100243)2.16070012
77Uterine leiomyosarcoma (HP:0002891)2.16070012
78Macrocytic anemia (HP:0001972)2.15822988
79Abnormality of the astrocytes (HP:0100707)2.11772967
80Astrocytoma (HP:0009592)2.11772967
81Agnosia (HP:0010524)2.11730682
82Colon cancer (HP:0003003)2.11608861
83Abnormality of cochlea (HP:0000375)2.11547597
84Oral leukoplakia (HP:0002745)2.10373119
85Heterotopia (HP:0002282)2.09130237
86Gastrointestinal inflammation (HP:0004386)2.08381056
87Ectopic kidney (HP:0000086)2.08320336
88Nephroblastoma (Wilms tumor) (HP:0002667)2.06924679
89Short thumb (HP:0009778)2.04925355
90Abnormal gallbladder physiology (HP:0012438)2.04855373
91Cholecystitis (HP:0001082)2.04855373
92Purpura (HP:0000979)2.03753700
93Abnormality of the duodenum (HP:0002246)2.03644601
94Aplasia/Hypoplasia of the patella (HP:0006498)2.03409005
95Hypoplasia of the capital femoral epiphysis (HP:0003090)1.98832445
96Cortical dysplasia (HP:0002539)1.98415699
97Abnormality of the renal collecting system (HP:0004742)1.97038921
98Progressive muscle weakness (HP:0003323)1.96945483
99Erythema (HP:0010783)1.96511078
100Glioma (HP:0009733)1.96052403
10111 pairs of ribs (HP:0000878)1.95060547
102Hepatocellular carcinoma (HP:0001402)1.94846001
103Autoimmune hemolytic anemia (HP:0001890)1.94825341
104Deviation of the thumb (HP:0009603)1.94459603
105Abnormality of the carotid arteries (HP:0005344)1.93845245
106Absent thumb (HP:0009777)1.91278674
107Tinnitus (HP:0000360)1.89201458
108Aplasia/Hypoplasia of the sternum (HP:0006714)1.88334563
109Pallor (HP:0000980)1.87834062
110Embryonal renal neoplasm (HP:0011794)1.87257691
111Long eyelashes (HP:0000527)1.87165375
112Proximal placement of thumb (HP:0009623)1.85822832
113Acute lymphatic leukemia (HP:0006721)1.85264836
114Freckling (HP:0001480)1.85121102
115Septate vagina (HP:0001153)1.84888787
116Abnormality of oral frenula (HP:0000190)1.84335622
117Neoplasm of the oral cavity (HP:0100649)1.83753248
118Duplicated collecting system (HP:0000081)1.83712506
119Dysautonomia (HP:0002459)1.83317783
120Bone marrow hypocellularity (HP:0005528)1.82707615
121Lymphoma (HP:0002665)1.81491481
122Abnormality of chromosome segregation (HP:0002916)1.80989212
123Spastic diplegia (HP:0001264)1.78772460
124Hypoplasia of the pons (HP:0012110)1.78681556
125Ulnar bowing (HP:0003031)1.78525323
126Microtia (HP:0008551)1.75650050
127Abnormality of cells of the lymphoid lineage (HP:0012140)1.75649820
128Arteriovenous malformation (HP:0100026)1.74960084
129Absent frontal sinuses (HP:0002688)1.74811167
130Bladder carcinoma (HP:0002862)1.74270875
131Bladder neoplasm (HP:0009725)1.74270875
132Hyperacusis (HP:0010780)1.74209314
133Truncal obesity (HP:0001956)1.74209026
134Epistaxis (HP:0000421)1.73894834
135Malignant gastrointestinal tract tumors (HP:0006749)1.72367632
136Gastrointestinal carcinoma (HP:0002672)1.72367632
137Rough bone trabeculation (HP:0100670)1.71372555
138Breast hypoplasia (HP:0003187)1.71266725
139Clubbing of toes (HP:0100760)1.70875557
140Lymphopenia (HP:0001888)1.70497210
141Poikiloderma (HP:0001029)1.69864445
142Deep philtrum (HP:0002002)1.69842192
143Ridged nail (HP:0001807)1.69732323
144Short middle phalanx of the 5th finger (HP:0004220)1.68355107
145Hyponatremia (HP:0002902)1.68351534
146Cellulitis (HP:0100658)1.68328244
147Deep palmar crease (HP:0006191)1.67925031
148Entropion (HP:0000621)1.67462291
149T lymphocytopenia (HP:0005403)1.66986480
150Hypopigmentation of the fundus (HP:0007894)1.66770501
151Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.66445516
152Biliary tract neoplasm (HP:0100574)1.65585552
153Abnormal number of incisors (HP:0011064)1.63987048

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.42653928
2ZAK6.34762099
3STK43.99095932
4VRK13.66671907
5CDC73.34913473
6CDK122.87433362
7RPS6KA52.79127672
8NEK22.12162808
9EIF2AK11.97225499
10AURKB1.87302529
11MAP3K81.85993244
12PIM11.80624745
13WEE11.79163865
14MAP3K101.77138640
15EEF2K1.72632635
16CDK91.71141961
17SCYL21.66931034
18BUB11.44542152
19CHEK21.42637801
20GRK61.41066955
21TRIB31.32181884
22SMG11.29902192
23DYRK31.29435671
24TTK1.26100629
25SRPK11.15335438
26PLK11.10040548
27STK101.06640688
28AURKA1.03719859
29NEK11.03562725
30RPS6KB21.02785241
31BRD41.01904536
32PKN21.01768145
33PKN11.01746024
34ATR0.99909297
35IRAK30.94435169
36BRAF0.92974087
37CDK40.89631287
38NME20.88520589
39DAPK30.86291089
40CDK60.84973763
41PRKAA10.84420851
42CAMK1D0.82238769
43PLK30.80613727
44CDK80.79305736
45BRSK10.78045162
46CHEK10.77843949
47BRSK20.76851912
48TAF10.76808241
49BTK0.76357522
50STK160.75669362
51PASK0.72530152
52ICK0.70891994
53MELK0.70769492
54MAP2K30.68543661
55ATM0.66782050
56PIM20.65816193
57EPHA20.65213473
58DYRK1B0.63683343
59IRAK40.63568689
60TTN0.63552279
61MST40.63267180
62CDK70.62645410
63FLT30.61304653
64STK30.59824122
65BLK0.59004278
66CDK20.58965829
67ILK0.58366621
68RAF10.57752215
69ACVR1B0.56609719
70AKT20.54878849
71CDK10.49650921
72ARAF0.49570249
73TRPM70.46429031
74PRPF4B0.46281992
75PBK0.42464736
76CCNB10.40931774
77MAP2K70.40567717
78EIF2AK20.38766095
79CSNK1D0.38762824
80LRRK20.35601222
81NEK90.33428432
82BMPR20.33198865
83JAK20.32095569
84KDR0.31712982
85PIK3CG0.31026945
86PLK40.30800633
87TEC0.29265098
88SGK10.28674266
89KSR20.27329809
90MAP3K40.26502985
91CSNK1G30.25712210
92PAK10.25519566
93PRKDC0.25032557
94TSSK60.23966279
95MAPKAPK30.23511770
96EIF2AK30.23133162
97MAPK110.23049650
98AKT10.22665983
99MAPK140.22617677
100PRKCQ0.22574812
101MTOR0.22177463
102MAP4K10.21632247
103IRAK20.21058203
104CAMKK20.20933458
105PRKCI0.20481932
106FRK0.20410044
107PRKCD0.19979805
108MST1R0.19898605
109MAP2K40.19739456
110CSNK1G10.19653862
111CLK10.19525201
112SYK0.19459190
113MAP3K20.18918227
114MARK30.18223595
115CSNK1A1L0.18167842
116TGFBR10.17850613
117RIPK40.17360800
118ERBB20.17125726
119RPS6KA30.15776090
120ALK0.15009918
121SGK30.13855928
122ROCK10.13361598
123CAMK1G0.13204357
124TESK20.12860142
125RPS6KB10.12858646
126BMX0.12740957
127FGR0.12727072
128CSNK2A20.12317594
129CAMK40.12066704
130LYN0.11847461
131RPS6KA40.11760356
132RET0.11604755
133STK240.09493852
134HCK0.09374211
135CHUK0.08425081
136LATS10.08376258
137PRKCB0.08181687
138CDK150.08152966
139GSK3B0.08061428
140RPS6KC10.07603278
141MAPKAPK50.07506986

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.33488361
2* Viral carcinogenesis_Homo sapiens_hsa052033.26767416
3DNA replication_Homo sapiens_hsa030303.11221386
4Mismatch repair_Homo sapiens_hsa034302.55597103
5Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.46026721
6Cell cycle_Homo sapiens_hsa041102.25213552
7* Systemic lupus erythematosus_Homo sapiens_hsa0532211.1577198
8One carbon pool by folate_Homo sapiens_hsa006701.85166591
9Base excision repair_Homo sapiens_hsa034101.76307317
10Non-homologous end-joining_Homo sapiens_hsa034501.69919209
11Transcriptional misregulation in cancer_Homo sapiens_hsa052021.67996349
12Fanconi anemia pathway_Homo sapiens_hsa034601.66971902
13Nucleotide excision repair_Homo sapiens_hsa034201.63626237
14Homologous recombination_Homo sapiens_hsa034401.63216293
15RNA transport_Homo sapiens_hsa030131.47418499
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42739119
17Spliceosome_Homo sapiens_hsa030401.26096414
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25309942
19p53 signaling pathway_Homo sapiens_hsa041151.22750419
20Ribosome_Homo sapiens_hsa030101.19595528
21mRNA surveillance pathway_Homo sapiens_hsa030150.99336166
22Pyrimidine metabolism_Homo sapiens_hsa002400.86681708
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85247790
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83874366
25MicroRNAs in cancer_Homo sapiens_hsa052060.83172344
26Small cell lung cancer_Homo sapiens_hsa052220.79836029
27Oocyte meiosis_Homo sapiens_hsa041140.74135987
28Non-small cell lung cancer_Homo sapiens_hsa052230.73218545
29Malaria_Homo sapiens_hsa051440.70929599
30Hematopoietic cell lineage_Homo sapiens_hsa046400.70158796
31Chronic myeloid leukemia_Homo sapiens_hsa052200.69912688
32Herpes simplex infection_Homo sapiens_hsa051680.69516838
33RNA degradation_Homo sapiens_hsa030180.66074149
34Selenocompound metabolism_Homo sapiens_hsa004500.64283751
35HTLV-I infection_Homo sapiens_hsa051660.61904575
36RNA polymerase_Homo sapiens_hsa030200.61795954
37Apoptosis_Homo sapiens_hsa042100.58286880
38Epstein-Barr virus infection_Homo sapiens_hsa051690.55347721
39Bladder cancer_Homo sapiens_hsa052190.54577950
40Antigen processing and presentation_Homo sapiens_hsa046120.53170821
41Hepatitis B_Homo sapiens_hsa051610.46769667
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45617969
43Pancreatic cancer_Homo sapiens_hsa052120.43220227
44Measles_Homo sapiens_hsa051620.42464799
45Sulfur relay system_Homo sapiens_hsa041220.42033010
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40473109
47N-Glycan biosynthesis_Homo sapiens_hsa005100.39842202
48Galactose metabolism_Homo sapiens_hsa000520.39389453
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37829855
50Prostate cancer_Homo sapiens_hsa052150.37703310
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.37604202
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37568066
53FoxO signaling pathway_Homo sapiens_hsa040680.37386217
54Dorso-ventral axis formation_Homo sapiens_hsa043200.37024858
55Vitamin B6 metabolism_Homo sapiens_hsa007500.36872507
56Glioma_Homo sapiens_hsa052140.35545808
57Lysine degradation_Homo sapiens_hsa003100.34959638
58Fructose and mannose metabolism_Homo sapiens_hsa000510.34857173
59B cell receptor signaling pathway_Homo sapiens_hsa046620.34552024
60Proteasome_Homo sapiens_hsa030500.33567691
61Carbon metabolism_Homo sapiens_hsa012000.32349435
62Basal transcription factors_Homo sapiens_hsa030220.30546715
63Primary immunodeficiency_Homo sapiens_hsa053400.29175354
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29062013
65mTOR signaling pathway_Homo sapiens_hsa041500.29005013
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28526207
67Purine metabolism_Homo sapiens_hsa002300.28480903
68Colorectal cancer_Homo sapiens_hsa052100.26345311
69Asthma_Homo sapiens_hsa053100.26116581
70Allograft rejection_Homo sapiens_hsa053300.25799365
71Autoimmune thyroid disease_Homo sapiens_hsa053200.24057814
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.22819179
73Influenza A_Homo sapiens_hsa051640.22691618
74Endometrial cancer_Homo sapiens_hsa052130.22498991
75Sulfur metabolism_Homo sapiens_hsa009200.22341682
76Inositol phosphate metabolism_Homo sapiens_hsa005620.22120330
77TGF-beta signaling pathway_Homo sapiens_hsa043500.21982282
78Melanoma_Homo sapiens_hsa052180.21543801
79Viral myocarditis_Homo sapiens_hsa054160.21107853
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20938400
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19977602
82Thyroid cancer_Homo sapiens_hsa052160.19356400
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19204925
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18489313
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17456760
86Pentose phosphate pathway_Homo sapiens_hsa000300.17278170
87Biosynthesis of amino acids_Homo sapiens_hsa012300.17251851
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.16734709
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.16700686
90VEGF signaling pathway_Homo sapiens_hsa043700.14796475
91Folate biosynthesis_Homo sapiens_hsa007900.14668393
92Graft-versus-host disease_Homo sapiens_hsa053320.14585251
93Shigellosis_Homo sapiens_hsa051310.14247961
94Proteoglycans in cancer_Homo sapiens_hsa052050.13976940
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13711239
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13335483
97Pathways in cancer_Homo sapiens_hsa052000.13274231
98ErbB signaling pathway_Homo sapiens_hsa040120.13271857
99HIF-1 signaling pathway_Homo sapiens_hsa040660.13123722
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.12977126
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.12765309
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.12568102
103AMPK signaling pathway_Homo sapiens_hsa041520.12400080
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11384938
105Basal cell carcinoma_Homo sapiens_hsa052170.11249939
106Legionellosis_Homo sapiens_hsa051340.11167406
107Notch signaling pathway_Homo sapiens_hsa043300.10758514
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.10579758
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10490583
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.10011597
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.09817599
112ABC transporters_Homo sapiens_hsa020100.09625159
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.09462217
114Platelet activation_Homo sapiens_hsa046110.09271411
115Toxoplasmosis_Homo sapiens_hsa051450.09071653
116Renin-angiotensin system_Homo sapiens_hsa046140.08661042
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.08446437
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.08289514
119Acute myeloid leukemia_Homo sapiens_hsa052210.07102352
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.06847562
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.06620715
122Leishmaniasis_Homo sapiens_hsa051400.06538201
123Hippo signaling pathway_Homo sapiens_hsa043900.06376249
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.05726392
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.04179082
126Adherens junction_Homo sapiens_hsa045200.04120265

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