HIST1H2BK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family. The protein encoded is an antimicrobial protein with antibacterial and antifungal activity. Two transcripts that encode the same protein have been identified for this gene, which is found in the histone microcluster on chromosome 6p21.33. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome assembly (GO:0006335)9.42076657
2DNA replication-dependent nucleosome organization (GO:0034723)9.42076657
3chromatin assembly (GO:0031497)7.81783666
4nucleosome assembly (GO:0006334)7.43639374
5regulation of histone H3-K9 methylation (GO:0051570)7.08113489
6* mucosal immune response (GO:0002385)6.60501597
7nucleosome organization (GO:0034728)6.41281584
8protein-DNA complex assembly (GO:0065004)6.26940060
9nuclear pore complex assembly (GO:0051292)6.06997535
10mitotic chromosome condensation (GO:0007076)6.01279014
11* organ or tissue specific immune response (GO:0002251)5.96316059
12nuclear pore organization (GO:0006999)5.95667098
13chromatin assembly or disassembly (GO:0006333)5.90728086
14protein localization to kinetochore (GO:0034501)5.69759210
15DNA unwinding involved in DNA replication (GO:0006268)5.68868658
16protein-DNA complex subunit organization (GO:0071824)5.59335242
17sister chromatid segregation (GO:0000819)5.37862616
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.36514685
19protein localization to chromosome, centromeric region (GO:0071459)4.94337696
20mitotic sister chromatid segregation (GO:0000070)4.82992150
21protoporphyrinogen IX metabolic process (GO:0046501)4.79453636
22pore complex assembly (GO:0046931)4.59544470
23chromatin remodeling at centromere (GO:0031055)4.43198292
24CENP-A containing nucleosome assembly (GO:0034080)4.42589600
25regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.36346488
26protoporphyrinogen IX biosynthetic process (GO:0006782)4.33852563
27DNA replication initiation (GO:0006270)4.30796091
28folic acid-containing compound biosynthetic process (GO:0009396)4.29010059
29regulation of centriole replication (GO:0046599)4.19862342
30positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.18863645
31positive regulation of mitotic sister chromatid separation (GO:1901970)4.18863645
32positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.18863645
33negative regulation of histone methylation (GO:0031061)4.16490478
34regulation of gene silencing (GO:0060968)4.13490387
35positive regulation of chromosome segregation (GO:0051984)4.12629077
36protein K6-linked ubiquitination (GO:0085020)4.11170264
37mitotic nuclear envelope disassembly (GO:0007077)4.08248375
38chromosome condensation (GO:0030261)4.08135840
39kinetochore organization (GO:0051383)4.06921527
40DNA duplex unwinding (GO:0032508)4.03370634
41DNA geometric change (GO:0032392)4.03201574
42DNA replication-independent nucleosome assembly (GO:0006336)4.01622623
43DNA replication-independent nucleosome organization (GO:0034724)4.01622623
44regulation of DNA endoreduplication (GO:0032875)4.01268292
45mitotic sister chromatid cohesion (GO:0007064)3.98420714
46regulation of sister chromatid cohesion (GO:0007063)3.94211150
47proline biosynthetic process (GO:0006561)3.93002682
48membrane disassembly (GO:0030397)3.88676687
49nuclear envelope disassembly (GO:0051081)3.88676687
50regulation of centrosome cycle (GO:0046605)3.85856501
51DNA strand elongation involved in DNA replication (GO:0006271)3.83309512
52microtubule depolymerization (GO:0007019)3.77743926
53dosage compensation (GO:0007549)3.76643458
54IMP biosynthetic process (GO:0006188)3.74320528
55histone exchange (GO:0043486)3.71699480
56meiotic chromosome segregation (GO:0045132)3.71610552
57* antibacterial humoral response (GO:0019731)3.66990055
58mitotic recombination (GO:0006312)3.66358317
59attachment of spindle microtubules to kinetochore (GO:0008608)3.65125671
60immunoglobulin mediated immune response (GO:0016064)3.64236949
61DNA strand elongation (GO:0022616)3.63543044
62regulation of posttranscriptional gene silencing (GO:0060147)3.61104552
63regulation of gene silencing by miRNA (GO:0060964)3.61104552
64regulation of gene silencing by RNA (GO:0060966)3.61104552
65regulation of centrosome duplication (GO:0010824)3.59791462
66DNA topological change (GO:0006265)3.58628966
67telomere maintenance via semi-conservative replication (GO:0032201)3.56327745
68translesion synthesis (GO:0019985)3.51668435
69DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.50836986
70erythrocyte maturation (GO:0043249)3.49746003
71B cell receptor signaling pathway (GO:0050853)3.48652019
72DNA packaging (GO:0006323)3.48471510
73B cell mediated immunity (GO:0019724)3.48179223
74mitotic metaphase plate congression (GO:0007080)3.46912522
75DNA conformation change (GO:0071103)3.45278890
76protein localization to chromosome (GO:0034502)3.44053054
77metaphase plate congression (GO:0051310)3.39976570
78regulation of chromosome segregation (GO:0051983)3.39337119
79positive regulation of histone methylation (GO:0031062)3.39054402
80viral mRNA export from host cell nucleus (GO:0046784)3.37968759
81* antimicrobial humoral response (GO:0019730)3.37342348
82* innate immune response in mucosa (GO:0002227)3.36015535
83regulation of translational fidelity (GO:0006450)3.34741612
84regulation of spindle organization (GO:0090224)3.34558520
85IMP metabolic process (GO:0046040)3.34025535
86chromosome segregation (GO:0007059)3.32175346
87negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.31914699
88negative regulation of B cell apoptotic process (GO:0002903)3.30520537
89postreplication repair (GO:0006301)3.30026234
90telomere maintenance via recombination (GO:0000722)3.28014175
91regulation of RNA export from nucleus (GO:0046831)3.26357110
92regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.25412185
93pre-miRNA processing (GO:0031054)3.24293052
94DNA synthesis involved in DNA repair (GO:0000731)3.24108842
95ATP-dependent chromatin remodeling (GO:0043044)3.21312178
96regulation of mitotic metaphase/anaphase transition (GO:0030071)3.19876303
97spindle checkpoint (GO:0031577)3.18299566
98establishment of chromosome localization (GO:0051303)3.15094578
99DNA replication checkpoint (GO:0000076)3.13930682
100porphyrin-containing compound biosynthetic process (GO:0006779)3.12871227
101regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.11375586
102DNA damage response, signal transduction resulting in transcription (GO:0042772)3.07970777
103telomere maintenance (GO:0000723)3.06422682
104mitotic DNA integrity checkpoint (GO:0044774)3.04152256
105regulation of mitotic spindle organization (GO:0060236)3.03299406
106spindle assembly checkpoint (GO:0071173)3.03235200
107nucleotide-excision repair, DNA gap filling (GO:0006297)3.02783680
108telomere organization (GO:0032200)3.02503727
109regulation of megakaryocyte differentiation (GO:0045652)2.94873102
110peptidyl-arginine omega-N-methylation (GO:0035247)2.91089913
111formation of translation preinitiation complex (GO:0001731)2.84881155
112* defense response to Gram-positive bacterium (GO:0050830)2.84456343
113deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.82625173
114regulation of B cell apoptotic process (GO:0002902)2.80487910
115B cell proliferation (GO:0042100)2.69382946
116antigen processing and presentation of endogenous antigen (GO:0019883)2.66107375
117positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.63811545
118regulation of B cell receptor signaling pathway (GO:0050855)2.62754648
119positive regulation of B cell differentiation (GO:0045579)2.61149319
120telomere maintenance via telomere lengthening (GO:0010833)2.57697441
121deoxyribonucleotide biosynthetic process (GO:0009263)2.53341371
122mitochondrial DNA metabolic process (GO:0032042)2.53145408
123Golgi transport vesicle coating (GO:0048200)2.51667622
124COPI coating of Golgi vesicle (GO:0048205)2.51667622
125T-helper 1 type immune response (GO:0042088)2.49892624
126nucleobase-containing small molecule interconversion (GO:0015949)2.47105375
127positive regulation of alpha-beta T cell proliferation (GO:0046641)2.46805136
128antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.46592291
129rRNA transcription (GO:0009303)2.45000979
130mature B cell differentiation involved in immune response (GO:0002313)2.42234762
131proline metabolic process (GO:0006560)2.42029966
132regulation of mammary gland epithelial cell proliferation (GO:0033599)2.40843927
133regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.38894323
134antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.37929677
135protein maturation by protein folding (GO:0022417)2.37120752
136positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.36460322
137T cell migration (GO:0072678)2.35951810
138nuclear envelope organization (GO:0006998)2.35166542
139positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.33010938
140tRNA aminoacylation for protein translation (GO:0006418)2.28732447
141spliceosomal tri-snRNP complex assembly (GO:0000244)2.27286418
142negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.26349062
143B cell homeostasis (GO:0001782)2.24723724
144pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.24522225
145ribosomal small subunit biogenesis (GO:0042274)2.22680762
146amino acid activation (GO:0043038)2.21512106
147tRNA aminoacylation (GO:0043039)2.21512106

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.97816333
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.93359088
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.24369532
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.93679134
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.61049739
6* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.95752599
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66055226
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.33792507
9* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.28970649
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.20393132
11* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18873415
12SOX2_16153702_ChIP-ChIP_HESCs_Human2.10874314
13* E2F1_21310950_ChIP-Seq_MCF-7_Human2.10096868
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse15.5802144
15NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92697370
16MYC_18555785_ChIP-Seq_MESCs_Mouse1.81695413
17* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.76798791
18SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.69742001
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65691778
20AR_21909140_ChIP-Seq_LNCAP_Human1.60476528
21ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58371282
22* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56960394
23* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.55369322
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54739071
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.54517681
26SOX2_18555785_ChIP-Seq_MESCs_Mouse1.53739942
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.49923642
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48464734
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45963810
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41769591
31KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.40472790
32MAF_26560356_Chip-Seq_TH1_Human1.40303743
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.39626896
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35866253
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32488022
36IRF1_19129219_ChIP-ChIP_H3396_Human1.32389994
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32353239
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.31847955
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31386834
40* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30407404
41* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.28961600
42ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28352933
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27633166
44VDR_23849224_ChIP-Seq_CD4+_Human1.26072391
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22449073
46KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20513763
47DCP1A_22483619_ChIP-Seq_HELA_Human1.18455197
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.17466040
49NANOG_16153702_ChIP-ChIP_HESCs_Human1.17322141
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15214073
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10361030
52TCF3_18692474_ChIP-Seq_MESCs_Mouse1.10149978
53* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.08948722
54DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08889057
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06952477
56MYC_22102868_ChIP-Seq_BL_Human1.04321589
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03810298
58* ELK1_19687146_ChIP-ChIP_HELA_Human1.02400864
59MYB_26560356_Chip-Seq_TH1_Human1.02302451
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01655788
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01140282
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00465170
63NCOR1_26117541_ChIP-Seq_K562_Human1.00342232
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98928785
65GATA1_22025678_ChIP-Seq_K562_Human0.98017311
66MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96300682
67* UTX_26944678_Chip-Seq_JUKART_Human0.93832389
68* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93363791
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92056206
70CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90180652
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89188803
72THAP11_20581084_ChIP-Seq_MESCs_Mouse0.88946809
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88556197
74MYB_26560356_Chip-Seq_TH2_Human0.88248190
75NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.88122072
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87812852
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87293229
78RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87153997
79MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.86465189
80MYCN_18555785_ChIP-Seq_MESCs_Mouse0.85842541
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85444443
82SPI1_23547873_ChIP-Seq_NB4_Human0.85267127
83FOXP3_21729870_ChIP-Seq_TREG_Human0.85130830
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85107551
85RUNX1_22412390_ChIP-Seq_EML_Mouse0.85053820
86ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84677344
87SCL_19346495_ChIP-Seq_HPC-7_Human0.83937076
88ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.83885719
89VDR_24763502_ChIP-Seq_THP-1_Human0.83585062
90* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83095967
91XRN2_22483619_ChIP-Seq_HELA_Human0.82611138
92* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.81822755
93KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.79629309
94* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.79086895
95* POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.77463214
96ZFX_18555785_ChIP-Seq_MESCs_Mouse0.77023750
97* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.76325666
98CREB1_15753290_ChIP-ChIP_HEK293T_Human0.76257231
99* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74174094
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.73077032
101HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.72474187
102NANOG_21062744_ChIP-ChIP_HESCs_Human0.72341471
103ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.72031170
104GATA1_19941826_ChIP-Seq_K562_Human0.69466195
105VDR_21846776_ChIP-Seq_THP-1_Human0.69344991
106NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.69179792
107PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.67736990
108SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.64909748
109MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.63861514
110KDM5A_27292631_Chip-Seq_BREAST_Human0.63849518
111GATA2_22383799_ChIP-Seq_G1ME_Mouse0.63569160
112EST1_17652178_ChIP-ChIP_JURKAT_Human0.63339424
113SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.63219495
114PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.62434498
115RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.61909008
116POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.61874318
117CIITA_25753668_ChIP-Seq_RAJI_Human0.60449184
118MYC_18940864_ChIP-ChIP_HL60_Human0.59116820
119TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.57191020
120HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.56922048
121POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.54570035
122GATA1_22383799_ChIP-Seq_G1ME_Mouse0.54432023
123KLF4_18555785_ChIP-Seq_MESCs_Mouse0.53898416
124TTF2_22483619_ChIP-Seq_HELA_Human0.53844454
125ZNF263_19887448_ChIP-Seq_K562_Human0.53381853
126ETS1_20019798_ChIP-Seq_JURKAT_Human0.52963028

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.92099154
2MP0003111_abnormal_nucleus_morphology4.38493303
3MP0010307_abnormal_tumor_latency3.93169458
4MP0003077_abnormal_cell_cycle3.80239373
5MP0003693_abnormal_embryo_hatching3.63408998
6MP0003656_abnormal_erythrocyte_physiolo3.32326215
7MP0008057_abnormal_DNA_replication3.22927615
8MP0004957_abnormal_blastocyst_morpholog3.21406572
9MP0004147_increased_porphyrin_level3.20862398
10MP0000685_abnormal_immune_system3.12942547
11MP0010352_gastrointestinal_tract_polyps2.99114251
12MP0003705_abnormal_hypodermis_morpholog2.93036836
13MP0005464_abnormal_platelet_physiology2.80114642
14MP0001835_abnormal_antigen_presentation2.79618571
15MP0005645_abnormal_hypothalamus_physiol2.55709884
16MP0003763_abnormal_thymus_physiology2.48534388
17MP0005671_abnormal_response_to2.47794583
18MP0003123_paternal_imprinting2.44422886
19MP0005076_abnormal_cell_differentiation2.40077234
20MP0008058_abnormal_DNA_repair2.38878364
21MP0010234_abnormal_vibrissa_follicle2.34413232
22MP0000350_abnormal_cell_proliferation2.31529410
23MP0001730_embryonic_growth_arrest2.27057628
24MP0003121_genomic_imprinting2.21341901
25MP0006054_spinal_hemorrhage2.15904522
26MP0001800_abnormal_humoral_immune2.12651044
27MP0008932_abnormal_embryonic_tissue2.11255970
28MP0008007_abnormal_cellular_replicative2.05629798
29MP0005451_abnormal_body_composition1.94887452
30MP0005000_abnormal_immune_tolerance1.91446313
31MP0005387_immune_system_phenotype1.89988298
32MP0001790_abnormal_immune_system1.89988298
33MP0004197_abnormal_fetal_growth/weight/1.87467193
34MP0009697_abnormal_copulation1.86655369
35MP0008877_abnormal_DNA_methylation1.84198992
36MP0002086_abnormal_extraembryonic_tissu1.82473316
37MP0004808_abnormal_hematopoietic_stem1.78604777
38MP0001697_abnormal_embryo_size1.77256966
39MP0002084_abnormal_developmental_patter1.74091411
40MP0001672_abnormal_embryogenesis/_devel1.73750838
41MP0005380_embryogenesis_phenotype1.73750838
42MP0001661_extended_life_span1.71171136
43MP0000537_abnormal_urethra_morphology1.67949536
44MP0002396_abnormal_hematopoietic_system1.62655371
45MP0002085_abnormal_embryonic_tissue1.61907497
46MP0009333_abnormal_splenocyte_physiolog1.60210221
47MP0002080_prenatal_lethality1.58934724
48MP0002723_abnormal_immune_serum1.57263488
49MP0002452_abnormal_antigen_presenting1.57000008
50MP0000490_abnormal_crypts_of1.55188178
51MP0002420_abnormal_adaptive_immunity1.53959876
52MP0003984_embryonic_growth_retardation1.51966426
53MP0000716_abnormal_immune_system1.50330050
54MP0002088_abnormal_embryonic_growth/wei1.49978646
55MP0001819_abnormal_immune_cell1.49364234
56MP0001727_abnormal_embryo_implantation1.45951096
57MP0002019_abnormal_tumor_incidence1.43972514
58MP0003937_abnormal_limbs/digits/tail_de1.37486942
59MP0006035_abnormal_mitochondrial_morpho1.35637466
60MP0003787_abnormal_imprinting1.31719080
61MP0009053_abnormal_anal_canal1.30255392
62MP0002009_preneoplasia1.28611692
63MP0000313_abnormal_cell_death1.28169619
64MP0003303_peritoneal_inflammation1.26729575
65MP0003786_premature_aging1.26275461
66MP0004947_skin_inflammation1.25472936
67MP0000358_abnormal_cell_content/1.24087221
68MP0005083_abnormal_biliary_tract1.23995898
69MP0004264_abnormal_extraembryonic_tissu1.23794862
70MP0001293_anophthalmia1.23667477
71MP0000465_gastrointestinal_hemorrhage1.21988964
72MP0005025_abnormal_response_to1.21791048
73MP0000703_abnormal_thymus_morphology1.15327582
74MP0002877_abnormal_melanocyte_morpholog1.11814795
75MP0010155_abnormal_intestine_physiology1.11255356
76MP0003890_abnormal_embryonic-extraembry1.10249993
77MP0002138_abnormal_hepatobiliary_system1.09452822
78MP0002697_abnormal_eye_size1.07529309
79MP0005310_abnormal_salivary_gland1.07343460
80MP0002092_abnormal_eye_morphology1.06418346
81MP0000733_abnormal_muscle_development1.05875774
82MP0003436_decreased_susceptibility_to1.04986460
83MP0009703_decreased_birth_body1.04937933
84MP0002166_altered_tumor_susceptibility1.03622423
85MP0008770_decreased_survivor_rate1.03577676
86MP0003806_abnormal_nucleotide_metabolis1.02889629
87MP0002111_abnormal_tail_morphology1.02761056
88MP0001915_intracranial_hemorrhage1.02739039
89MP0003183_abnormal_peptide_metabolism1.02475816
90MP0003567_abnormal_fetal_cardiomyocyte1.02329693
91MP0001845_abnormal_inflammatory_respons1.02134875
92MP0002722_abnormal_immune_system0.99645159
93MP0002398_abnormal_bone_marrow0.98097012
94MP0009785_altered_susceptibility_to0.96600250
95MP0000858_altered_metastatic_potential0.96119707
96MP0009672_abnormal_birth_weight0.94953858
97MP0002132_abnormal_respiratory_system0.94496574
98MP0003566_abnormal_cell_adhesion0.91929014
99MP0002148_abnormal_hypersensitivity_rea0.90709930
100MP0010678_abnormal_skin_adnexa0.89822841
101MP0000689_abnormal_spleen_morphology0.88995869
102MP0001849_ear_inflammation0.88852274
103MP0001873_stomach_inflammation0.87207528
104MP0003300_gastrointestinal_ulcer0.86829842
105MP0002006_tumorigenesis0.86135339
106MP0001545_abnormal_hematopoietic_system0.85566815
107MP0005397_hematopoietic_system_phenotyp0.85566815
108MP0008260_abnormal_autophagy0.85241114
109MP0010030_abnormal_orbit_morphology0.85220791
110MP0005501_abnormal_skin_physiology0.83082126
111MP0005621_abnormal_cell_physiology0.82786420
112MP0005384_cellular_phenotype0.81791916
113MP0002925_abnormal_cardiovascular_devel0.81558102
114MP0005023_abnormal_wound_healing0.81389367
115MP0002419_abnormal_innate_immunity0.80990955
116MP0008995_early_reproductive_senescence0.80899360
117MP0000015_abnormal_ear_pigmentation0.79910564
118MP0005220_abnormal_exocrine_pancreas0.79808797
119MP0004185_abnormal_adipocyte_glucose0.78730129
120MP0004233_abnormal_muscle_weight0.72229768
121MP0005058_abnormal_lysosome_morphology0.72147449
122MP0005187_abnormal_penis_morphology0.71869489
123MP0001286_abnormal_eye_development0.71768564
124MP0000609_abnormal_liver_physiology0.70924852
125MP0001853_heart_inflammation0.69274445
126MP0000598_abnormal_liver_morphology0.68899580
127MP0008438_abnormal_cutaneous_collagen0.68483031
128MP0003861_abnormal_nervous_system0.68186878
129MP0002429_abnormal_blood_cell0.67540762
130MP0000428_abnormal_craniofacial_morphol0.67096233
131MP0002210_abnormal_sex_determination0.66854300
132MP0002095_abnormal_skin_pigmentation0.66459061
133MP0000432_abnormal_head_morphology0.66312338
134MP0009763_increased_sensitivity_to0.65977860
135MP0001145_abnormal_male_reproductive0.65638218
136MP0001929_abnormal_gametogenesis0.63838708
137MP0003119_abnormal_digestive_system0.63634013
138MP0000266_abnormal_heart_morphology0.62905961
139MP0003718_maternal_effect0.62121218
140MP0003115_abnormal_respiratory_system0.60790569
141MP0000477_abnormal_intestine_morphology0.60686056
142MP0003453_abnormal_keratinocyte_physiol0.60039748
143MP0009931_abnormal_skin_appearance0.57045196
144MP0009278_abnormal_bone_marrow0.56745750
145MP0005623_abnormal_meninges_morphology0.56332938
146MP0000653_abnormal_sex_gland0.56197903
147MP0000569_abnormal_digit_pigmentation0.54546842
148MP0006072_abnormal_retinal_apoptosis0.54377534

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)5.97903231
2IgM deficiency (HP:0002850)5.44209395
3IgA deficiency (HP:0002720)5.42497135
4Gastrointestinal stroma tumor (HP:0100723)5.34116557
5Hypochromic microcytic anemia (HP:0004840)4.93399205
6Abnormal gallbladder physiology (HP:0012438)4.65383605
7Cholecystitis (HP:0001082)4.65383605
8Petechiae (HP:0000967)4.32557891
9Acanthocytosis (HP:0001927)4.01761429
10Abnormality of the heme biosynthetic pathway (HP:0010472)3.82124528
11Chromsome breakage (HP:0040012)3.76776928
12Agammaglobulinemia (HP:0004432)3.71789121
13Recurrent sinusitis (HP:0011108)3.69373658
14Colitis (HP:0002583)3.66519342
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.63613707
16Cellulitis (HP:0100658)3.60026589
17Impulsivity (HP:0100710)3.50540198
18Lymphopenia (HP:0001888)3.39046887
19Abnormality of chromosome stability (HP:0003220)3.38206712
20Abnormality of cells of the lymphoid lineage (HP:0012140)3.29887855
21Recurrent bronchitis (HP:0002837)3.29417711
22Ependymoma (HP:0002888)3.23366135
23Volvulus (HP:0002580)3.18497918
24Reticulocytosis (HP:0001923)3.11968696
25Cutaneous melanoma (HP:0012056)3.11546990
26Abnormality of reticulocytes (HP:0004312)3.06210112
27Birth length less than 3rd percentile (HP:0003561)3.01489265
28Meningitis (HP:0001287)2.96629713
29Reticulocytopenia (HP:0001896)2.95972628
30Purpura (HP:0000979)2.94484303
31Abnormality of the astrocytes (HP:0100707)2.93386780
32Astrocytoma (HP:0009592)2.93386780
33Abnormal platelet volume (HP:0011876)2.92294144
34Medulloblastoma (HP:0002885)2.86846897
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.83473021
36Short 4th metacarpal (HP:0010044)2.83473021
37Prolonged bleeding time (HP:0003010)2.80317636
38Abnormality of T cell physiology (HP:0011840)2.78198015
39Dry hair (HP:0011359)2.76145945
40Abnormality of the labia minora (HP:0012880)2.76074785
41Rhabdomyosarcoma (HP:0002859)2.75168666
42Increased mean platelet volume (HP:0011877)2.69661457
43Colon cancer (HP:0003003)2.69420625
44Emphysema (HP:0002097)2.65940786
45Cortical dysplasia (HP:0002539)2.65049964
46Cafe-au-lait spot (HP:0000957)2.63464718
47High pitched voice (HP:0001620)2.63101306
48Inflammation of the large intestine (HP:0002037)2.62173539
49Basal cell carcinoma (HP:0002671)2.61547694
50Agnosia (HP:0010524)2.58550579
51Gastrointestinal inflammation (HP:0004386)2.57540614
52Lymphoma (HP:0002665)2.55814735
53Onycholysis (HP:0001806)2.55774669
54Chronic diarrhea (HP:0002028)2.55761412
55Recurrent viral infections (HP:0004429)2.54071038
56Eczematoid dermatitis (HP:0000976)2.52254718
57Hypertensive crisis (HP:0100735)2.51548338
58Urticaria (HP:0001025)2.50944065
59Osteomyelitis (HP:0002754)2.50943361
60Erythema (HP:0010783)2.49585216
61Selective tooth agenesis (HP:0001592)2.49455344
62Prominent nose (HP:0000448)2.48376821
63Autoimmune hemolytic anemia (HP:0001890)2.48067616
64Sandal gap (HP:0001852)2.43599739
65Glioma (HP:0009733)2.43071039
66Small intestinal stenosis (HP:0012848)2.41129954
67Duodenal stenosis (HP:0100867)2.41129954
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.40440833
69Increased nuchal translucency (HP:0010880)2.40025842
70Vasculitis (HP:0002633)2.39436482
71Biliary tract neoplasm (HP:0100574)2.38834152
72Chronic obstructive pulmonary disease (HP:0006510)2.38276084
73Obstructive lung disease (HP:0006536)2.38276084
74IgG deficiency (HP:0004315)2.37395180
75Meckel diverticulum (HP:0002245)2.35598010
76Menorrhagia (HP:0000132)2.35480042
77Recurrent bacterial skin infections (HP:0005406)2.33583600
78Hypochromic anemia (HP:0001931)2.31860906
79Abnormal platelet function (HP:0011869)2.31305579
80Impaired platelet aggregation (HP:0003540)2.31305579
81Microvesicular hepatic steatosis (HP:0001414)2.30975373
82Insomnia (HP:0100785)2.30246840
83Abnormality of the fingertips (HP:0001211)2.28800034
84Neoplasm of the oral cavity (HP:0100649)2.26974212
85Leukopenia (HP:0001882)2.26321693
86Deviation of the thumb (HP:0009603)2.26276081
87Abnormality of the ileum (HP:0001549)2.23750805
88Recurrent pneumonia (HP:0006532)2.22577811
89Orthostatic hypotension (HP:0001278)2.22434218
90Ulnar bowing (HP:0003031)2.21934141
91Gastrointestinal carcinoma (HP:0002672)2.19502748
92Malignant gastrointestinal tract tumors (HP:0006749)2.19502748
93Squamous cell carcinoma (HP:0002860)2.19184643
94Proximal placement of thumb (HP:0009623)2.18386963
95Abnormality of macrophages (HP:0004311)2.17966217
96Cholelithiasis (HP:0001081)2.17628295
97Mediastinal lymphadenopathy (HP:0100721)2.17078133
98Hypopigmentation of the fundus (HP:0007894)2.16900630
99Epistaxis (HP:0000421)2.16228046
100Abnormality of glycolysis (HP:0004366)2.15996259
101Sloping forehead (HP:0000340)2.15326733
102Abnormality of the preputium (HP:0100587)2.14503392
103Heterotopia (HP:0002282)2.13647024
104Ectopic kidney (HP:0000086)2.13560949
105Myelodysplasia (HP:0002863)2.11590252
106Ridged nail (HP:0001807)2.10873875
107Recurrent lower respiratory tract infections (HP:0002783)2.10458763
108Abnormality of the prostate (HP:0008775)2.08535660
109Septate vagina (HP:0001153)2.07334451
110Skin rash (HP:0000988)2.06625890
111Spastic diplegia (HP:0001264)2.05872325
112Patellar aplasia (HP:0006443)2.05321789
113Subacute progressive viral hepatitis (HP:0006572)2.04380252
114Recurrent abscess formation (HP:0002722)2.03640805
115Abnormality of pyrimidine metabolism (HP:0004353)2.02993463
116Abnormality of the duodenum (HP:0002246)2.02917948
117Neoplasm of striated muscle (HP:0009728)2.02084900
118Hepatitis (HP:0012115)2.00326147
119Freckling (HP:0001480)1.98183328
120Aplasia/Hypoplasia of the sacrum (HP:0008517)1.98015800
121Abnormality of the 4th metacarpal (HP:0010012)1.96023509
122Aplasia/Hypoplasia of the sternum (HP:0006714)1.95903364
123Macrocytic anemia (HP:0001972)1.95241980
124Hypergonadotropic hypogonadism (HP:0000815)1.95109467
125Papilloma (HP:0012740)1.94996066
126Verrucae (HP:0200043)1.94996066
127Absent frontal sinuses (HP:0002688)1.93854992
128Aplasia/Hypoplasia of the thymus (HP:0010515)1.93145074
129Abnormality of the carotid arteries (HP:0005344)1.92643698
130Increased IgM level (HP:0003496)1.91940205
131Atresia of the external auditory canal (HP:0000413)1.89931019
132Truncal obesity (HP:0001956)1.89134668
133B lymphocytopenia (HP:0010976)1.89013970
134Panhypogammaglobulinemia (HP:0003139)1.87652965
135Thyroiditis (HP:0100646)1.87531128
136Aplasia/Hypoplasia of the patella (HP:0006498)1.86417486
137Abnormality of T cells (HP:0002843)1.85958601
138Ovarian neoplasm (HP:0100615)1.85351647
139Absent thumb (HP:0009777)1.85246160
140Abnormality of cells of the erythroid lineage (HP:0012130)1.84734084
141Missing ribs (HP:0000921)1.84004644
142Abnormality of chromosome segregation (HP:0002916)1.83493699
14311 pairs of ribs (HP:0000878)1.82664803
144Abnormal gallbladder morphology (HP:0012437)1.81558221
145Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.80446673
146Microtia (HP:0008551)1.79935821
147Abnormality of DNA repair (HP:0003254)1.79577434
148Intestinal polyposis (HP:0200008)1.79205593
149Neoplasm of the pancreas (HP:0002894)1.78353771
150Acute hepatic failure (HP:0006554)1.78059408
151Progressive muscle weakness (HP:0003323)1.77872642
152Absent radius (HP:0003974)1.76425661
153Abnormal lung lobation (HP:0002101)1.75326049
154Pancreatic islet-cell hyperplasia (HP:0004510)1.74975094
155Nephroblastoma (Wilms tumor) (HP:0002667)1.74387687
156Entropion (HP:0000621)1.73826319
157Viral hepatitis (HP:0006562)1.73659458
158Long eyelashes (HP:0000527)1.73641908
159Intestinal polyp (HP:0005266)1.72982115
160Abnormality of the gallbladder (HP:0005264)1.72040158
161Long clavicles (HP:0000890)1.71489459
162Recurrent otitis media (HP:0000403)1.71263190
163Amaurosis fugax (HP:0100576)1.71163747
164Progressive external ophthalmoplegia (HP:0000590)1.71053270
165Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70524758
166Tinnitus (HP:0000360)1.69009473
167Prostate neoplasm (HP:0100787)1.68541434
168Renovascular hypertension (HP:0100817)1.68443236
169Restrictive lung disease (HP:0002091)1.67491419
170Breast hypoplasia (HP:0003187)1.67434472
171Neoplasm of the small intestine (HP:0100833)1.67267049
172Poikiloderma (HP:0001029)1.66911326
173Abnormal delayed hypersensitivity skin test (HP:0002963)1.66473930
174Abnormality of the calcaneus (HP:0008364)1.66402392
175Cutaneous photosensitivity (HP:0000992)1.66260659
176Deep philtrum (HP:0002002)1.65902559
177Hepatocellular carcinoma (HP:0001402)1.65576931
178Ankyloglossia (HP:0010296)1.64730771
179Ureteral duplication (HP:0000073)1.63601629

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.70562612
2ZAK6.39581324
3VRK13.54419226
4STK43.30758780
5CDC73.25081594
6RPS6KA52.75460729
7SMG12.25230337
8NEK22.10024600
9CDK122.07209140
10MAP3K102.03338420
11SCYL21.93179731
12CDK91.92633520
13EEF2K1.85998040
14AURKB1.71846921
15MAP3K81.71451908
16PIM11.70902177
17WEE11.64739698
18SRPK11.57226866
19PKN21.53006857
20CHEK21.49572727
21RIPK41.45625637
22BUB11.42639682
23EIF2AK11.28534976
24TTK1.28366442
25IRAK41.27586938
26RPS6KB21.27371439
27NEK11.15829037
28BTK1.14612169
29DYRK31.10184909
30PKN11.07798209
31GRK61.06994710
32PLK11.05945872
33BCKDK1.03324395
34ATR1.03102501
35EPHA21.00319753
36MST40.98107471
37IRAK30.96845810
38AURKA0.96398493
39DAPK30.95749235
40BRAF0.92821916
41STK100.90503964
42CDK40.90196688
43ICK0.88218162
44SYK0.86199448
45BLK0.86129731
46PASK0.84713893
47MAP4K10.83961334
48ACVR1B0.82573587
49ARAF0.82241214
50CCNB10.81686882
51PLK30.81047266
52FLT30.78927130
53TAF10.78810418
54TTN0.78733613
55CHEK10.77896125
56CAMK1D0.77722097
57MELK0.77247008
58VRK20.76162929
59CDK60.76086971
60PIM20.71841321
61ATM0.70105587
62KSR20.69567927
63PRPF4B0.69186059
64TESK20.68684746
65RAF10.67625358
66DYRK1B0.67296088
67STK30.63781932
68BRSK20.62501683
69BMPR20.61629247
70BRD40.61524027
71CDK20.61122690
72PRKAA10.60844245
73AKT20.60353440
74KDR0.57996111
75FRK0.57879187
76LATS10.56861175
77MAP2K30.54977575
78CDK70.54944626
79NME20.54435424
80CDK80.49851566
81CDK10.49020891
82NEK90.45588786
83LYN0.45456225
84CSNK1D0.45297961
85FGFR20.44120923
86EIF2AK30.43204754
87TBK10.42560305
88LRRK20.42052343
89TGFBR10.41902324
90BRSK10.40476240
91STK160.40334631
92IKBKB0.40058421
93KSR10.36109391
94PIK3CG0.35157903
95MTOR0.34310522
96ILK0.33583305
97MAP3K140.33381340
98CSF1R0.32105019
99TRIB30.32094503
100TEC0.30771390
101JAK30.30527902
102MAP3K130.29889213
103EIF2AK20.28720382
104JAK20.28177530
105PLK40.28025430
106PRKDC0.27627342
107ALK0.26080193
108ROCK10.26011106
109PAK10.25556729
110PAK40.25097582
111MAPKAPK50.24792347
112TRPM70.24747936
113PDGFRA0.24407022
114HCK0.23985161
115CSNK1G30.23864738
116MAPK140.23326627
117PTK60.22291000
118RPS6KA40.22275664
119PBK0.20650941
120AKT10.20484872
121MET0.20353619
122ERN10.20334986
123PRKCD0.19305870
124PRKCQ0.19050670
125CSNK1A1L0.18562516
126FGR0.18331561
127MAP3K20.18180133
128FGFR40.18045235
129RPS6KB10.17436576
130TSSK60.16975532
131SGK10.16649633
132IKBKE0.16273750
133BMX0.16156589
134CSNK2A20.15869357
135RPS6KA30.14119141
136PAK20.13215307
137CLK10.13075366
138MKNK10.12405805
139FGFR10.11258161
140MARK30.10996125
141CAMK1G0.10279178
142ERBB20.10188505
143MAPK110.09945276
144MAPKAPK30.09802130
145MAPK10.08691812
146RIPK10.08287918

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.54671102
2* Viral carcinogenesis_Homo sapiens_hsa052033.31959899
3DNA replication_Homo sapiens_hsa030302.85489820
4Mismatch repair_Homo sapiens_hsa034302.47593440
5Cell cycle_Homo sapiens_hsa041102.08245163
6One carbon pool by folate_Homo sapiens_hsa006702.05850249
7* Systemic lupus erythematosus_Homo sapiens_hsa0532211.5177320
8Primary immunodeficiency_Homo sapiens_hsa053401.84998481
9Transcriptional misregulation in cancer_Homo sapiens_hsa052021.81919331
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.74454405
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64448061
12Non-homologous end-joining_Homo sapiens_hsa034501.63842234
13Allograft rejection_Homo sapiens_hsa053301.63192104
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60616682
15RNA transport_Homo sapiens_hsa030131.57094340
16Nucleotide excision repair_Homo sapiens_hsa034201.55323521
17Fanconi anemia pathway_Homo sapiens_hsa034601.55112546
18Autoimmune thyroid disease_Homo sapiens_hsa053201.50320915
19Base excision repair_Homo sapiens_hsa034101.48811349
20Asthma_Homo sapiens_hsa053101.41005554
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40977405
22Homologous recombination_Homo sapiens_hsa034401.39168851
23Graft-versus-host disease_Homo sapiens_hsa053321.33165828
24Spliceosome_Homo sapiens_hsa030401.25760990
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.24234126
26p53 signaling pathway_Homo sapiens_hsa041151.06920853
27Type I diabetes mellitus_Homo sapiens_hsa049401.04692074
28mRNA surveillance pathway_Homo sapiens_hsa030151.02669489
29MicroRNAs in cancer_Homo sapiens_hsa052060.93143064
30Ribosome_Homo sapiens_hsa030100.92515212
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91907002
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89240473
33Selenocompound metabolism_Homo sapiens_hsa004500.86069049
34Leishmaniasis_Homo sapiens_hsa051400.84262161
35Fructose and mannose metabolism_Homo sapiens_hsa000510.80705858
36Small cell lung cancer_Homo sapiens_hsa052220.79544538
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79127274
38Pyrimidine metabolism_Homo sapiens_hsa002400.70443990
39Oocyte meiosis_Homo sapiens_hsa041140.68395359
40Chronic myeloid leukemia_Homo sapiens_hsa052200.67699986
41Non-small cell lung cancer_Homo sapiens_hsa052230.65802944
42RNA degradation_Homo sapiens_hsa030180.63014198
43HTLV-I infection_Homo sapiens_hsa051660.61791209
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60231862
45Bladder cancer_Homo sapiens_hsa052190.57436416
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56986395
47Galactose metabolism_Homo sapiens_hsa000520.51921839
48Lysine degradation_Homo sapiens_hsa003100.51453497
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51188597
50Herpes simplex infection_Homo sapiens_hsa051680.49719422
51Epstein-Barr virus infection_Homo sapiens_hsa051690.49356855
52RNA polymerase_Homo sapiens_hsa030200.48710155
53Acute myeloid leukemia_Homo sapiens_hsa052210.46227512
54mTOR signaling pathway_Homo sapiens_hsa041500.45945786
55Apoptosis_Homo sapiens_hsa042100.42600108
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.41420803
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40664167
58Antigen processing and presentation_Homo sapiens_hsa046120.39774943
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39344712
60Colorectal cancer_Homo sapiens_hsa052100.38685889
61Biosynthesis of amino acids_Homo sapiens_hsa012300.38352540
62Glioma_Homo sapiens_hsa052140.37806672
63Pancreatic cancer_Homo sapiens_hsa052120.36902678
64Prostate cancer_Homo sapiens_hsa052150.36299297
65Hepatitis B_Homo sapiens_hsa051610.36057490
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35883391
67TGF-beta signaling pathway_Homo sapiens_hsa043500.34520968
68N-Glycan biosynthesis_Homo sapiens_hsa005100.34171210
69Staphylococcus aureus infection_Homo sapiens_hsa051500.32385228
70FoxO signaling pathway_Homo sapiens_hsa040680.32175095
71Vitamin B6 metabolism_Homo sapiens_hsa007500.31965643
72Shigellosis_Homo sapiens_hsa051310.29990233
73Hippo signaling pathway_Homo sapiens_hsa043900.28179617
74Basal transcription factors_Homo sapiens_hsa030220.28128705
75Proteoglycans in cancer_Homo sapiens_hsa052050.27851114
76Phenylalanine metabolism_Homo sapiens_hsa003600.27446908
77Toxoplasmosis_Homo sapiens_hsa051450.27374821
78Endometrial cancer_Homo sapiens_hsa052130.27284796
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25995338
80Thyroid cancer_Homo sapiens_hsa052160.25385284
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25276058
82Hematopoietic cell lineage_Homo sapiens_hsa046400.25128217
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25102259
84Pyruvate metabolism_Homo sapiens_hsa006200.24445281
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23841070
86Sulfur relay system_Homo sapiens_hsa041220.23766126
87Basal cell carcinoma_Homo sapiens_hsa052170.23268717
88Melanoma_Homo sapiens_hsa052180.23177663
89Nitrogen metabolism_Homo sapiens_hsa009100.22319604
90B cell receptor signaling pathway_Homo sapiens_hsa046620.22078998
91Adherens junction_Homo sapiens_hsa045200.21961958
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21915274
93Sulfur metabolism_Homo sapiens_hsa009200.21745602
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.21358744
95Purine metabolism_Homo sapiens_hsa002300.21160803
96Renin-angiotensin system_Homo sapiens_hsa046140.20939517
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.20478164
98Pentose phosphate pathway_Homo sapiens_hsa000300.19860365
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19410587
100Tuberculosis_Homo sapiens_hsa051520.18582117
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18558945
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.17928636
103Pathways in cancer_Homo sapiens_hsa052000.16809457
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16786282
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15562956
106HIF-1 signaling pathway_Homo sapiens_hsa040660.15492167
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15144753
108AMPK signaling pathway_Homo sapiens_hsa041520.14725437
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.14621492
110Measles_Homo sapiens_hsa051620.14614519
111Proteasome_Homo sapiens_hsa030500.14486929
112Arginine biosynthesis_Homo sapiens_hsa002200.14323747
113Tight junction_Homo sapiens_hsa045300.14186897
114Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.13811374
115Malaria_Homo sapiens_hsa051440.13664507
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12766068
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.12349828
118Phagosome_Homo sapiens_hsa041450.12299994
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.11941319
120Focal adhesion_Homo sapiens_hsa045100.11927292
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.11537632
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.10518154
123Viral myocarditis_Homo sapiens_hsa054160.10361825
124Legionellosis_Homo sapiens_hsa051340.09836940
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.09368115
126Dorso-ventral axis formation_Homo sapiens_hsa043200.09070841
127Notch signaling pathway_Homo sapiens_hsa043300.08892047
128Carbon metabolism_Homo sapiens_hsa012000.08397727
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.07808944
130Inositol phosphate metabolism_Homo sapiens_hsa005620.07251176
131Influenza A_Homo sapiens_hsa051640.07129704
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.05675656
133Platelet activation_Homo sapiens_hsa046110.05591673
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.05122704

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