HIST1H2BL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome organization (GO:0034723)8.56952131
2DNA replication-dependent nucleosome assembly (GO:0006335)8.56952131
3chromatin assembly (GO:0031497)6.79457888
4regulation of histone H3-K9 methylation (GO:0051570)6.26778309
5nuclear pore complex assembly (GO:0051292)6.09296094
6* nucleosome assembly (GO:0006334)6.03007917
7nuclear pore organization (GO:0006999)5.89788338
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.50841217
9mitotic sister chromatid cohesion (GO:0007064)5.40910891
10DNA unwinding involved in DNA replication (GO:0006268)5.40857639
11* nucleosome organization (GO:0034728)5.27571999
12chromatin assembly or disassembly (GO:0006333)5.13483361
13protein localization to kinetochore (GO:0034501)5.04757418
14* protein-DNA complex assembly (GO:0065004)5.04577037
15sister chromatid segregation (GO:0000819)4.86348522
16mitotic chromosome condensation (GO:0007076)4.65404501
17antimicrobial humoral response (GO:0019730)4.63019128
18* protein-DNA complex subunit organization (GO:0071824)4.57244903
19pore complex assembly (GO:0046931)4.56152362
20antibacterial humoral response (GO:0019731)4.48577476
21negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.35621736
22protein localization to chromosome, centromeric region (GO:0071459)4.35013555
23innate immune response in mucosa (GO:0002227)4.27728127
24mitotic sister chromatid segregation (GO:0000070)4.18998262
25mitotic nuclear envelope disassembly (GO:0007077)4.16634744
26kinetochore organization (GO:0051383)4.09697100
27regulation of sister chromatid cohesion (GO:0007063)4.05145022
28folic acid-containing compound biosynthetic process (GO:0009396)4.03962220
29DNA replication initiation (GO:0006270)4.02352325
30regulation of DNA endoreduplication (GO:0032875)3.97717430
31nuclear envelope disassembly (GO:0051081)3.91002020
32membrane disassembly (GO:0030397)3.91002020
33IMP biosynthetic process (GO:0006188)3.90271541
34regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.89347261
35V(D)J recombination (GO:0033151)3.84496184
36CENP-A containing nucleosome assembly (GO:0034080)3.78556855
37negative regulation of histone methylation (GO:0031061)3.78308802
38DNA duplex unwinding (GO:0032508)3.75575025
39chromatin remodeling at centromere (GO:0031055)3.75485894
40DNA geometric change (GO:0032392)3.74677818
41positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.74363440
42positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.74363440
43positive regulation of mitotic sister chromatid separation (GO:1901970)3.74363440
44positive regulation of chromosome segregation (GO:0051984)3.72143616
45pre-miRNA processing (GO:0031054)3.70755441
46microtubule depolymerization (GO:0007019)3.65187108
47DNA replication checkpoint (GO:0000076)3.64543609
48DNA strand elongation involved in DNA replication (GO:0006271)3.62583833
49DNA synthesis involved in DNA repair (GO:0000731)3.60775152
50regulation of translational fidelity (GO:0006450)3.60124770
51defense response to Gram-positive bacterium (GO:0050830)3.59563586
52viral mRNA export from host cell nucleus (GO:0046784)3.58653121
53regulation of gene silencing (GO:0060968)3.57111218
54DNA replication-independent nucleosome organization (GO:0034724)3.56212673
55DNA replication-independent nucleosome assembly (GO:0006336)3.56212673
56regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.54272641
57regulation of centriole replication (GO:0046599)3.53490602
58response to UV-C (GO:0010225)3.52945811
59regulation of spindle organization (GO:0090224)3.46385264
60nucleotide-excision repair, DNA gap filling (GO:0006297)3.43816942
61DNA strand elongation (GO:0022616)3.43598755
62protoporphyrinogen IX metabolic process (GO:0046501)3.43529587
63dosage compensation (GO:0007549)3.40328686
64IMP metabolic process (GO:0046040)3.35843550
65non-recombinational repair (GO:0000726)3.35835597
66double-strand break repair via nonhomologous end joining (GO:0006303)3.35835597
67regulation of RNA export from nucleus (GO:0046831)3.35720361
68mitotic recombination (GO:0006312)3.34707018
69telomere maintenance via semi-conservative replication (GO:0032201)3.34353234
70regulation of chromosome segregation (GO:0051983)3.29708458
71attachment of spindle microtubules to kinetochore (GO:0008608)3.28292291
72regulation of mitotic metaphase/anaphase transition (GO:0030071)3.27741652
73telomere maintenance (GO:0000723)3.25620581
74telomere organization (GO:0032200)3.25522114
75mucosal immune response (GO:0002385)3.24795790
76regulation of posttranscriptional gene silencing (GO:0060147)3.24332486
77regulation of gene silencing by miRNA (GO:0060964)3.24332486
78regulation of gene silencing by RNA (GO:0060966)3.24332486
79chromosome condensation (GO:0030261)3.24032036
80DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.23794002
81meiotic chromosome segregation (GO:0045132)3.23316002
82protein K6-linked ubiquitination (GO:0085020)3.23286259
83spindle assembly checkpoint (GO:0071173)3.22551895
84regulation of centrosome cycle (GO:0046605)3.22418431
85histone exchange (GO:0043486)3.22085319
86spindle checkpoint (GO:0031577)3.21418792
87mitotic metaphase plate congression (GO:0007080)3.20380701
88regulation of megakaryocyte differentiation (GO:0045652)3.20139955
89regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.18622584
90translesion synthesis (GO:0019985)3.18306825
91maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.15331512
92kinetochore assembly (GO:0051382)3.12918287
93telomere maintenance via telomere lengthening (GO:0010833)3.12350966
94metaphase plate congression (GO:0051310)3.12343049
95DNA topological change (GO:0006265)3.10036929
96regulation of helicase activity (GO:0051095)3.09791450
97ATP-dependent chromatin remodeling (GO:0043044)3.09553758
98DNA conformation change (GO:0071103)3.06301301
99negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.06022772
100regulation of mitotic sister chromatid separation (GO:0010965)3.05904448
101regulation of mitotic sister chromatid segregation (GO:0033047)3.05904448
102regulation of sister chromatid segregation (GO:0033045)3.05904448
103negative regulation of chromosome segregation (GO:0051985)3.05564633
104protein localization to chromosome (GO:0034502)3.05530305
105regulation of mitotic spindle organization (GO:0060236)3.04650538
106organ or tissue specific immune response (GO:0002251)3.03905565
107regulation of centrosome duplication (GO:0010824)3.03045190
108ribosomal small subunit biogenesis (GO:0042274)3.03040014
109telomere maintenance via recombination (GO:0000722)3.02653502
110positive regulation of histone methylation (GO:0031062)3.01178170
111protein complex localization (GO:0031503)3.01101667
112positive regulation of cell cycle checkpoint (GO:1901978)3.00379543
113somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00208626
114somatic hypermutation of immunoglobulin genes (GO:0016446)3.00208626
115negative regulation of DNA repair (GO:0045738)3.00141095
116mitotic spindle assembly checkpoint (GO:0007094)2.99680615
117negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.99567021
118negative regulation of sister chromatid segregation (GO:0033046)2.99567021
119negative regulation of mitotic sister chromatid separation (GO:2000816)2.99567021
120negative regulation of mitotic sister chromatid segregation (GO:0033048)2.99567021
121DNA ligation (GO:0006266)2.98655255
122regulation of spindle checkpoint (GO:0090231)2.97660220
123mitotic spindle checkpoint (GO:0071174)2.96435314
124chromosome segregation (GO:0007059)2.91217443
125cellular protein complex localization (GO:0034629)2.90835406
126DNA packaging (GO:0006323)2.88117257
127rRNA transcription (GO:0009303)2.86982099

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.88767057
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.05725291
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.60369183
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.49983656
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.55186925
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.94788050
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.73240600
8* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.34273451
9* E2F1_21310950_ChIP-Seq_MCF-7_Human2.28570091
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.23364304
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.17539156
12* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09607421
13* SOX2_16153702_ChIP-ChIP_HESCs_Human2.03825468
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse14.2205425
15EGR1_19374776_ChIP-ChIP_THP-1_Human1.98632097
16MYC_18555785_ChIP-Seq_MESCs_Mouse1.97081484
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89419418
18AR_21909140_ChIP-Seq_LNCAP_Human1.85998094
19* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.85936836
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81336887
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.76970040
22ESR1_15608294_ChIP-ChIP_MCF-7_Human1.72826724
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71692440
24* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.70966890
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70458799
26SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.69585421
27HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.56739506
28* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56064173
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.55557751
30KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.52462353
31SOX2_18555785_ChIP-Seq_MESCs_Mouse1.51364727
32IRF1_19129219_ChIP-ChIP_H3396_Human1.50574822
33* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49387509
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47465842
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43538674
36* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41857218
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27076309
38NANOG_16153702_ChIP-ChIP_HESCs_Human1.23009093
39* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21072705
40* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20816444
41TCF3_18692474_ChIP-Seq_MESCs_Mouse1.20041067
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19004619
43* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17297630
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17266107
45* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17050228
46MYC_22102868_ChIP-Seq_BL_Human1.16732478
47* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12841991
48ELK1_19687146_ChIP-ChIP_HELA_Human1.11364362
49VDR_23849224_ChIP-Seq_CD4+_Human1.10437443
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10344017
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08556188
52* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06212230
53* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.05036527
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.00400271
55DCP1A_22483619_ChIP-Seq_HELA_Human1.00176169
56STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97999271
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97289392
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97062114
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95674166
60* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.95376215
61TP63_19390658_ChIP-ChIP_HaCaT_Human0.95355806
62PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94654796
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94133763
64* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90923145
65* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.89582706
66MYCN_18555785_ChIP-Seq_MESCs_Mouse0.88954225
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88259840
68* MYC_18940864_ChIP-ChIP_HL60_Human0.86532543
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.86430596
70CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85944851
71XRN2_22483619_ChIP-Seq_HELA_Human0.84153995
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83955022
73ZFX_18555785_ChIP-Seq_MESCs_Mouse0.81738730
74NANOG_21062744_ChIP-ChIP_HESCs_Human0.81055191
75* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.80257141
76FOXP3_21729870_ChIP-Seq_TREG_Human0.80118567
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79108384
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.79107259
79ELF1_17652178_ChIP-ChIP_JURKAT_Human0.78310376
80* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77831250
81NOTCH1_21737748_ChIP-Seq_TLL_Human0.77252717
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.77128503
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.76570444
84GATA1_22025678_ChIP-Seq_K562_Human0.76012019
85NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.75570798
86VDR_21846776_ChIP-Seq_THP-1_Human0.75332278
87ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.74865856
88IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.74348035
89SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.74029866
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.73724800
91PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.73437617
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.72969101
93MAF_26560356_Chip-Seq_TH1_Human0.72450262
94POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.72312020
95THAP11_20581084_ChIP-Seq_MESCs_Mouse0.71694365
96ZNF263_19887448_ChIP-Seq_K562_Human0.71010248
97CIITA_25753668_ChIP-Seq_RAJI_Human0.70375242
98GABP_17652178_ChIP-ChIP_JURKAT_Human0.70251323
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.68415498
100STAT4_19710469_ChIP-ChIP_TH1__Mouse0.68243707
101CREB1_15753290_ChIP-ChIP_HEK293T_Human0.66204030
102GATA1_19941826_ChIP-Seq_K562_Human0.65617411
103GABP_19822575_ChIP-Seq_HepG2_Human0.64408062
104TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.64291187
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.63699203
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.63614066
107* PKCTHETA_26484144_Chip-Seq_BREAST_Human0.63155649
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.63085526
109* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.63061424
110KDM5A_27292631_Chip-Seq_BREAST_Human0.62209170
111* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.61224362
112SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.61092619
113* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.60040866
114EST1_17652178_ChIP-ChIP_JURKAT_Human0.59931448
115TTF2_22483619_ChIP-Seq_HELA_Human0.59559236
116STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.57432879
117TCF3_18692474_ChIP-Seq_MEFs_Mouse0.57163248
118GATA2_22383799_ChIP-Seq_G1ME_Mouse0.56053777
119E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.55591507
120SCL_19346495_ChIP-Seq_HPC-7_Human0.55391965
121KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.54343836
122TCF7_22412390_ChIP-Seq_EML_Mouse0.53778552

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.04508133
2MP0003111_abnormal_nucleus_morphology3.55238135
3MP0010307_abnormal_tumor_latency3.07247586
4MP0003077_abnormal_cell_cycle3.06578933
5MP0008057_abnormal_DNA_replication3.03604153
6MP0010352_gastrointestinal_tract_polyps2.90654662
7MP0003693_abnormal_embryo_hatching2.70649760
8MP0003705_abnormal_hypodermis_morpholog2.59297657
9MP0004957_abnormal_blastocyst_morpholog2.57022604
10MP0003123_paternal_imprinting2.49569923
11MP0003121_genomic_imprinting2.47326606
12MP0005076_abnormal_cell_differentiation2.39177807
13MP0010030_abnormal_orbit_morphology2.29350253
14MP0002396_abnormal_hematopoietic_system2.23082270
15MP0003656_abnormal_erythrocyte_physiolo2.22905512
16MP0003763_abnormal_thymus_physiology2.15039798
17MP0004147_increased_porphyrin_level2.11010502
18MP0009053_abnormal_anal_canal2.00055546
19MP0009697_abnormal_copulation1.98906247
20MP0003937_abnormal_limbs/digits/tail_de1.96155561
21MP0006054_spinal_hemorrhage1.95364686
22MP0000350_abnormal_cell_proliferation1.94298628
23MP0001730_embryonic_growth_arrest1.93154058
24MP0010234_abnormal_vibrissa_follicle1.91436655
25MP0003890_abnormal_embryonic-extraembry1.90470222
26MP0001293_anophthalmia1.88163576
27MP0008877_abnormal_DNA_methylation1.84709208
28MP0008058_abnormal_DNA_repair1.84118728
29MP0000537_abnormal_urethra_morphology1.83681155
30MP0004197_abnormal_fetal_growth/weight/1.83555370
31MP0002877_abnormal_melanocyte_morpholog1.80485848
32MP0002086_abnormal_extraembryonic_tissu1.78628287
33MP0001661_extended_life_span1.78427142
34MP0002084_abnormal_developmental_patter1.77761302
35MP0004185_abnormal_adipocyte_glucose1.76163923
36MP0008932_abnormal_embryonic_tissue1.73453167
37MP0001697_abnormal_embryo_size1.72573453
38MP0005380_embryogenesis_phenotype1.70440905
39MP0001672_abnormal_embryogenesis/_devel1.70440905
40MP0008007_abnormal_cellular_replicative1.67860918
41MP0002085_abnormal_embryonic_tissue1.65015302
42MP0004808_abnormal_hematopoietic_stem1.58992136
43MP0003984_embryonic_growth_retardation1.57615733
44MP0005503_abnormal_tendon_morphology1.55731373
45MP0002088_abnormal_embryonic_growth/wei1.55006562
46MP0002080_prenatal_lethality1.42792613
47MP0003941_abnormal_skin_development1.41330261
48MP0009703_decreased_birth_body1.40618573
49MP0000428_abnormal_craniofacial_morphol1.29858072
50MP0002163_abnormal_gland_morphology1.26404972
51MP0010678_abnormal_skin_adnexa1.25171246
52MP0002092_abnormal_eye_morphology1.24400924
53MP0003935_abnormal_craniofacial_develop1.20327568
54MP0004264_abnormal_extraembryonic_tissu1.19959797
55MP0009672_abnormal_birth_weight1.19416082
56MP0005645_abnormal_hypothalamus_physiol1.17553143
57MP0003718_maternal_effect1.16890610
58MP0000049_abnormal_middle_ear1.16875438
59MP0002398_abnormal_bone_marrow1.16074671
60MP0000383_abnormal_hair_follicle1.16011838
61MP0006035_abnormal_mitochondrial_morpho1.14570575
62MP0003567_abnormal_fetal_cardiomyocyte1.13510837
63MP0000358_abnormal_cell_content/1.12903829
64MP0002111_abnormal_tail_morphology1.12379363
65MP0000432_abnormal_head_morphology1.09516019
66MP0000685_abnormal_immune_system1.09021723
67MP0002722_abnormal_immune_system1.08863279
68MP0002249_abnormal_larynx_morphology1.07138137
69MP0002697_abnormal_eye_size1.07076914
70MP0005083_abnormal_biliary_tract1.07032028
71MP0004233_abnormal_muscle_weight1.06241618
72MP0003122_maternal_imprinting1.05927567
73MP0000490_abnormal_crypts_of1.05925460
74MP0004381_abnormal_hair_follicle1.05583982
75MP0003787_abnormal_imprinting1.04614459
76MP0002166_altered_tumor_susceptibility1.04075090
77MP0002019_abnormal_tumor_incidence1.04060384
78MP0002938_white_spotting1.03546766
79MP0003755_abnormal_palate_morphology1.01666500
80MP0000313_abnormal_cell_death1.01612233
81MP0002925_abnormal_cardiovascular_devel1.01448477
82MP0000733_abnormal_muscle_development1.00975072
83MP0003385_abnormal_body_wall1.00592753
84MP0005397_hematopoietic_system_phenotyp1.00414788
85MP0001545_abnormal_hematopoietic_system1.00414788
86MP0001915_intracranial_hemorrhage1.00055705
87MP0001286_abnormal_eye_development0.96829573
88MP0005220_abnormal_exocrine_pancreas0.96460550
89MP0005623_abnormal_meninges_morphology0.95509841
90MP0003115_abnormal_respiratory_system0.95117977
91MP0000703_abnormal_thymus_morphology0.94698933
92MP0002009_preneoplasia0.91339658
93MP0003119_abnormal_digestive_system0.91329525
94MP0001346_abnormal_lacrimal_gland0.90822041
95MP0005248_abnormal_Harderian_gland0.89860742
96MP0005187_abnormal_penis_morphology0.89722827
97MP0003566_abnormal_cell_adhesion0.89488354
98MP0002932_abnormal_joint_morphology0.88145811
99MP0005023_abnormal_wound_healing0.87937743
100MP0008770_decreased_survivor_rate0.86154678
101MP0003942_abnormal_urinary_system0.85790804
102MP0000689_abnormal_spleen_morphology0.85635713
103MP0001727_abnormal_embryo_implantation0.85432574
104MP0005384_cellular_phenotype0.84637841
105MP0003315_abnormal_perineum_morphology0.83606490
106MP0005621_abnormal_cell_physiology0.83148327
107MP0002160_abnormal_reproductive_system0.82222703
108MP0000566_synostosis0.82041734
109MP0002006_tumorigenesis0.82010292
110MP0008438_abnormal_cutaneous_collagen0.80152108
111MP0000015_abnormal_ear_pigmentation0.80017661
112MP0002095_abnormal_skin_pigmentation0.79635368
113MP0002210_abnormal_sex_determination0.78389040
114MP0001929_abnormal_gametogenesis0.77904162
115MP0002098_abnormal_vibrissa_morphology0.77213136
116MP0000266_abnormal_heart_morphology0.76799584
117MP0004272_abnormal_basement_membrane0.76689936
118MP0000427_abnormal_hair_cycle0.76363479
119MP0002429_abnormal_blood_cell0.76102826
120MP0005501_abnormal_skin_physiology0.75595487
121MP0003806_abnormal_nucleotide_metabolis0.75284548
122MP0002109_abnormal_limb_morphology0.74516510
123MP0000569_abnormal_digit_pigmentation0.74347888
124MP0000377_abnormal_hair_follicle0.74040268
125MP0005451_abnormal_body_composition0.72702271
126MP0009250_abnormal_appendicular_skeleto0.72690195
127MP0001849_ear_inflammation0.71483898
128MP0003786_premature_aging0.70497078
129MP0003861_abnormal_nervous_system0.70200234
130MP0002282_abnormal_trachea_morphology0.69462200
131MP0001145_abnormal_male_reproductive0.65485242
132MP0002060_abnormal_skin_morphology0.64822736
133MP0003699_abnormal_female_reproductive0.63776942
134MP0001216_abnormal_epidermal_layer0.60110479
135MP0000477_abnormal_intestine_morphology0.59776741
136MP0009931_abnormal_skin_appearance0.59666834
137MP0009379_abnormal_foot_pigmentation0.58145646
138MP0000716_abnormal_immune_system0.57030923
139MP0001191_abnormal_skin_condition0.56686982
140MP0005391_vision/eye_phenotype0.55716268
141MP0001119_abnormal_female_reproductive0.55193813
142MP0003453_abnormal_keratinocyte_physiol0.54111885
143MP0009278_abnormal_bone_marrow0.53321270
144MP0001835_abnormal_antigen_presentation0.52975159

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.76190703
2Short 4th metacarpal (HP:0010044)5.76190703
3IgM deficiency (HP:0002850)5.04524794
4IgA deficiency (HP:0002720)4.60016401
5Abnormality of the 4th metacarpal (HP:0010012)3.99222386
6Poikilocytosis (HP:0004447)3.91639998
7Chromsome breakage (HP:0040012)3.83562177
8Colitis (HP:0002583)3.82448617
9Hypochromic microcytic anemia (HP:0004840)3.73445553
10Medulloblastoma (HP:0002885)3.70375339
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.58060096
12Volvulus (HP:0002580)3.56190516
13Increased nuchal translucency (HP:0010880)3.10757170
14Colon cancer (HP:0003003)3.06553901
15B lymphocytopenia (HP:0010976)3.04059365
16Abnormality of chromosome stability (HP:0003220)3.00760179
17Abnormality of the heme biosynthetic pathway (HP:0010472)2.91435701
18Aplasia/Hypoplasia of the sacrum (HP:0008517)2.88875409
19Microvesicular hepatic steatosis (HP:0001414)2.87226098
20Meckel diverticulum (HP:0002245)2.86616008
21Abnormal lung lobation (HP:0002101)2.82207078
22Thyroiditis (HP:0100646)2.77290129
23Clubbing of toes (HP:0100760)2.76931657
24Abnormality of the ileum (HP:0001549)2.75386509
25Acanthocytosis (HP:0001927)2.67974347
26Ependymoma (HP:0002888)2.64257622
27Selective tooth agenesis (HP:0001592)2.63714641
28Impulsivity (HP:0100710)2.63565772
29Small intestinal stenosis (HP:0012848)2.63200039
30Duodenal stenosis (HP:0100867)2.63200039
31Asymmetry of the thorax (HP:0001555)2.60179214
3211 pairs of ribs (HP:0000878)2.58055353
33Cellulitis (HP:0100658)2.55516429
34Abnormality of cells of the erythroid lineage (HP:0012130)2.54911110
35Abnormality of the labia minora (HP:0012880)2.51206753
36Atresia of the external auditory canal (HP:0000413)2.50486622
37Acute lymphatic leukemia (HP:0006721)2.39035032
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.38872795
39Neoplasm of the oral cavity (HP:0100649)2.38300770
40Long eyelashes (HP:0000527)2.37806923
41Astrocytoma (HP:0009592)2.37683686
42Abnormality of the astrocytes (HP:0100707)2.37683686
43Abnormality of B cell number (HP:0010975)2.37629419
44Microglossia (HP:0000171)2.36541067
45Trigonocephaly (HP:0000243)2.35701975
46Ectopic kidney (HP:0000086)2.32098911
47Nephroblastoma (Wilms tumor) (HP:0002667)2.31104166
48Abnormality of pyrimidine metabolism (HP:0004353)2.30263705
49Deviation of the thumb (HP:0009603)2.29548317
50Abnormal number of incisors (HP:0011064)2.29531210
51Hyperacusis (HP:0010780)2.27040170
52Deep philtrum (HP:0002002)2.26459482
53Rhabdomyosarcoma (HP:0002859)2.25904380
54Absent frontal sinuses (HP:0002688)2.25687137
55Duplicated collecting system (HP:0000081)2.24048391
56Abnormality of the fingertips (HP:0001211)2.23647300
57Insomnia (HP:0100785)2.22561174
58Abnormality of DNA repair (HP:0003254)2.22226722
59Microtia (HP:0008551)2.20580932
60Short thumb (HP:0009778)2.20516008
61Proximal placement of thumb (HP:0009623)2.20146485
62Embryonal renal neoplasm (HP:0011794)2.17693027
63Prominent nose (HP:0000448)2.17260006
64Glioma (HP:0009733)2.16885630
65Midline defect of the nose (HP:0004122)2.14942837
66Gastrointestinal stroma tumor (HP:0100723)2.14064371
67Agnosia (HP:0010524)2.13350324
68Abnormality of the duodenum (HP:0002246)2.13033696
69Arteriovenous malformation (HP:0100026)2.12962383
70Abnormality of the preputium (HP:0100587)2.12073219
71Aplasia/Hypoplasia of the sternum (HP:0006714)2.09570910
72Broad thumb (HP:0011304)2.09527389
73Abnormal number of erythroid precursors (HP:0012131)2.09304645
74Reticulocytopenia (HP:0001896)2.09172234
75Inflammation of the large intestine (HP:0002037)2.08717486
76Spastic diplegia (HP:0001264)2.07947491
77Abnormality of reticulocytes (HP:0004312)2.07131593
78Cafe-au-lait spot (HP:0000957)2.06754503
79Breast hypoplasia (HP:0003187)2.06312539
80Reticulocytosis (HP:0001923)2.05983733
81Abnormality of the carotid arteries (HP:0005344)2.03773905
82Abnormality of abdominal situs (HP:0011620)2.03505130
83Abdominal situs inversus (HP:0003363)2.03505130
84Basal cell carcinoma (HP:0002671)2.03126609
85Missing ribs (HP:0000921)2.02605704
86Ureteral duplication (HP:0000073)1.99162492
87Gastrointestinal inflammation (HP:0004386)1.99051451
88Lymphoma (HP:0002665)1.98838894
89Embryonal neoplasm (HP:0002898)1.98729737
90Gastrointestinal carcinoma (HP:0002672)1.98365935
91Malignant gastrointestinal tract tumors (HP:0006749)1.98365935
92Abnormality of cochlea (HP:0000375)1.97719375
93High pitched voice (HP:0001620)1.97596989
94Orthostatic hypotension (HP:0001278)1.97199867
95Combined immunodeficiency (HP:0005387)1.95992595
96High anterior hairline (HP:0009890)1.94042004
97Myelodysplasia (HP:0002863)1.93864764
98Absent thumb (HP:0009777)1.93216169
99Hypergonadotropic hypogonadism (HP:0000815)1.93104402
100Birth length less than 3rd percentile (HP:0003561)1.92582049
101Fibular hypoplasia (HP:0003038)1.90466289
102Abnormality of the renal collecting system (HP:0004742)1.89932240
103Neoplasm of striated muscle (HP:0009728)1.89783254
104Biliary tract neoplasm (HP:0100574)1.87802807
105Cortical dysplasia (HP:0002539)1.86728380
106Renal duplication (HP:0000075)1.86491133
107Recurrent viral infections (HP:0004429)1.86067026
108Erythema (HP:0010783)1.85260707
109Limited elbow extension (HP:0001377)1.84908275
110Leiomyosarcoma (HP:0100243)1.84691305
111Uterine leiomyosarcoma (HP:0002891)1.84691305
112Bone marrow hypocellularity (HP:0005528)1.83933485
113Ankyloglossia (HP:0010296)1.82922724
114Facial hemangioma (HP:0000329)1.82636508
115Short middle phalanx of the 5th finger (HP:0004220)1.82497922
116Anal stenosis (HP:0002025)1.81184866
117Elfin facies (HP:0004428)1.81026369
118Absent radius (HP:0003974)1.80336621
119Progressive muscle weakness (HP:0003323)1.79609235
120Prostate neoplasm (HP:0100787)1.78858285
121Broad distal phalanx of finger (HP:0009836)1.78780072
122Skin tags (HP:0010609)1.78511957
123Abnormality of chromosome segregation (HP:0002916)1.78511659
124Cutaneous melanoma (HP:0012056)1.77989927
125Abnormality of the parietal bone (HP:0002696)1.77680225
126Progressive external ophthalmoplegia (HP:0000590)1.77128860
127Sloping forehead (HP:0000340)1.75602050
128Poikiloderma (HP:0001029)1.75323102
129Leukopenia (HP:0001882)1.74838661
130Hypoplasia of the maxilla (HP:0000327)1.74539984
131Tracheoesophageal fistula (HP:0002575)1.74496902
132Dry hair (HP:0011359)1.74430372
133Shallow orbits (HP:0000586)1.74207643
134Skull defect (HP:0001362)1.71688186
135Duplication of thumb phalanx (HP:0009942)1.71654512
136Broad phalanges of the hand (HP:0009768)1.70567732
137Supernumerary ribs (HP:0005815)1.70252665
138Hypochromic anemia (HP:0001931)1.70019190
139Sandal gap (HP:0001852)1.69454599
140Septate vagina (HP:0001153)1.68876390
141Increased number of teeth (HP:0011069)1.68872228
142Hypoplastic labia majora (HP:0000059)1.68076101
143Ankle contracture (HP:0006466)1.67990824
144Renovascular hypertension (HP:0100817)1.65953472
145Squamous cell carcinoma (HP:0002860)1.65037854
146Anteriorly placed anus (HP:0001545)1.64829195
147Abnormality of the distal phalanx of the thumb (HP:0009617)1.63774321
148Short humerus (HP:0005792)1.63605754
149Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.63064040
150Truncal obesity (HP:0001956)1.62573906
151Narrow palate (HP:0000189)1.61123865
152Intestinal polyposis (HP:0200008)1.60818546
153Large earlobe (HP:0009748)1.60384354
154Intestinal polyp (HP:0005266)1.59592316
155Supernumerary bones of the axial skeleton (HP:0009144)1.59491153
156Delayed closure of the anterior fontanelle (HP:0001476)1.58463351

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK18.72084440
2ZAK6.23242731
3CDC73.56413085
4VRK13.54837951
5STK43.21009365
6RPS6KA52.53359428
7CDK122.43162767
8NEK22.17311875
9MAP3K101.94319704
10CDK91.92257717
11LATS11.75627697
12EEF2K1.69022689
13AURKB1.68850423
14SMG11.67109062
15EPHA31.64755930
16SCYL21.64460147
17WEE11.59246880
18MAP3K81.57092545
19PBK1.55045833
20PIM11.54270786
21CHEK21.51263881
22CAMK1D1.33539600
23TTK1.32634699
24ATR1.29887455
25BUB11.28232984
26TAF11.22698521
27NEK11.20570979
28SRPK11.20059659
29RPS6KB21.14903603
30TRIB31.13973977
31EIF2AK11.09403745
32NME21.08627811
33PLK11.08596182
34PKN21.06572290
35STK31.04393883
36PLK31.02289086
37CDK70.98433952
38STK100.93162435
39CDK60.91509343
40CDK40.88852137
41CHEK10.88349357
42TTN0.88014165
43SIK10.87325153
44FGFR20.86237476
45ATM0.86165357
46DYRK30.85079687
47AURKA0.84042137
48EPHA20.83595378
49BRD40.81213335
50FLT30.78385487
51CCNB10.77116105
52BRAF0.74686622
53PKN10.73592583
54CDK20.72808748
55MTOR0.72359411
56BRSK20.70210297
57PASK0.67750733
58CDK80.66017436
59MELK0.65412526
60CDK10.60684958
61CAMK1G0.60617501
62DAPK30.60380251
63STK160.60039000
64PRPF4B0.59995557
65FRK0.58802606
66ACVR1B0.57161799
67AKT20.55863304
68GRK60.54267182
69FGFR10.54063992
70ICK0.53685628
71RPS6KA40.52614122
72PDGFRA0.51284228
73BTK0.50845368
74LRRK20.50071190
75CSNK1D0.49009935
76MAPK110.49007286
77NUAK10.46610610
78PAK40.44448664
79PRKAA10.44282790
80EIF2AK20.43686385
81PLK40.43276071
82DYRK1B0.42432072
83MKNK10.40993388
84MET0.39229845
85TGFBR10.38487889
86RPS6KB10.37592102
87MAPK140.35635332
88PRKDC0.32673034
89NLK0.31774318
90AKT10.31622527
91CSNK1G30.30571995
92ROCK10.30013487
93BRSK10.29689966
94ERBB20.29122114
95ALK0.27456078
96MAP2K30.27376649
97CSNK1A1L0.26871901
98TSSK60.26770385
99PIM20.26434086
100IRAK30.25818649
101FGFR30.24959365
102CSF1R0.24940923
103EIF2AK30.24798415
104RAF10.24730984
105PAK10.24629450
106PTK60.24463263
107MAPK10.23545171
108KSR10.22837505
109PDGFRB0.22569801
110SGK30.21351824
111DMPK0.21283215
112BMX0.20951335
113CSNK2A20.19888114
114NEK90.18709265
115CAMK40.18539997
116VRK20.18382459
117MAPKAPK50.18323738
118GSK3B0.18169725
119PAK20.17436794
120MST1R0.17016326
121KDR0.16512187
122CAMKK20.16066263
123MAP2K70.15951073
124JAK20.15762967
125PRKCQ0.15342688
126CSNK1G10.15318623
127PIK3CG0.14748905
128IRAK40.12938574
129SYK0.11749045
130MST40.10814180
131MAP2K20.10350780
132BCKDK0.09454485
133CLK10.09196884
134ILK0.08491236
135RPS6KA10.07631270
136RPS6KL10.06830035
137RPS6KC10.06830035
138MAP3K20.06440531

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050345.91686156
2DNA replication_Homo sapiens_hsa030303.19073912
3* Viral carcinogenesis_Homo sapiens_hsa052033.11486961
4Mismatch repair_Homo sapiens_hsa034302.82270329
5Cell cycle_Homo sapiens_hsa041102.45034638
6One carbon pool by folate_Homo sapiens_hsa006702.31037992
7* Systemic lupus erythematosus_Homo sapiens_hsa0532210.3878694
8Transcriptional misregulation in cancer_Homo sapiens_hsa052021.90042443
9RNA transport_Homo sapiens_hsa030131.85669717
10Fanconi anemia pathway_Homo sapiens_hsa034601.83019087
11Non-homologous end-joining_Homo sapiens_hsa034501.69688124
12Base excision repair_Homo sapiens_hsa034101.65484440
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56641793
14Homologous recombination_Homo sapiens_hsa034401.53014952
15Nucleotide excision repair_Homo sapiens_hsa034201.52705876
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.51930402
17Spliceosome_Homo sapiens_hsa030401.34667982
18MicroRNAs in cancer_Homo sapiens_hsa052061.31110802
19p53 signaling pathway_Homo sapiens_hsa041151.24930193
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11946282
21Basal cell carcinoma_Homo sapiens_hsa052171.09730193
22mRNA surveillance pathway_Homo sapiens_hsa030151.09669115
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04730986
24Ribosome_Homo sapiens_hsa030100.99713643
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88128256
26Small cell lung cancer_Homo sapiens_hsa052220.87864795
27RNA degradation_Homo sapiens_hsa030180.85774452
28Selenocompound metabolism_Homo sapiens_hsa004500.85688241
29Lysine degradation_Homo sapiens_hsa003100.84687710
30HTLV-I infection_Homo sapiens_hsa051660.83783483
31Chronic myeloid leukemia_Homo sapiens_hsa052200.79655856
32Oocyte meiosis_Homo sapiens_hsa041140.79365713
33Primary immunodeficiency_Homo sapiens_hsa053400.76559311
34Pyrimidine metabolism_Homo sapiens_hsa002400.73683209
35Sulfur relay system_Homo sapiens_hsa041220.72949894
36Non-small cell lung cancer_Homo sapiens_hsa052230.72552069
37TGF-beta signaling pathway_Homo sapiens_hsa043500.69518020
38Hippo signaling pathway_Homo sapiens_hsa043900.67517202
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67146572
40Colorectal cancer_Homo sapiens_hsa052100.64823116
41Adherens junction_Homo sapiens_hsa045200.62503597
42Prostate cancer_Homo sapiens_hsa052150.60697168
43Bladder cancer_Homo sapiens_hsa052190.60203750
44Proteoglycans in cancer_Homo sapiens_hsa052050.59213334
45Hedgehog signaling pathway_Homo sapiens_hsa043400.58914736
46Herpes simplex infection_Homo sapiens_hsa051680.53967048
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52637356
48Thyroid cancer_Homo sapiens_hsa052160.50191642
49Renin-angiotensin system_Homo sapiens_hsa046140.49125337
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48653676
51Endometrial cancer_Homo sapiens_hsa052130.47548302
52Epstein-Barr virus infection_Homo sapiens_hsa051690.47298113
53mTOR signaling pathway_Homo sapiens_hsa041500.47200898
54Pathways in cancer_Homo sapiens_hsa052000.46746123
55Hepatitis B_Homo sapiens_hsa051610.45848790
56Melanoma_Homo sapiens_hsa052180.44129091
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.43824882
58Glioma_Homo sapiens_hsa052140.43179557
59Wnt signaling pathway_Homo sapiens_hsa043100.43021537
60Pancreatic cancer_Homo sapiens_hsa052120.40786428
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40475123
62Carbon metabolism_Homo sapiens_hsa012000.39605268
63FoxO signaling pathway_Homo sapiens_hsa040680.39176520
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36415497
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.36161214
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36008229
67Antigen processing and presentation_Homo sapiens_hsa046120.35912940
68Biosynthesis of amino acids_Homo sapiens_hsa012300.35387213
69N-Glycan biosynthesis_Homo sapiens_hsa005100.33058687
70Apoptosis_Homo sapiens_hsa042100.31797050
71Fructose and mannose metabolism_Homo sapiens_hsa000510.31441951
72Focal adhesion_Homo sapiens_hsa045100.31101990
73RNA polymerase_Homo sapiens_hsa030200.30809565
74Basal transcription factors_Homo sapiens_hsa030220.29332871
75Notch signaling pathway_Homo sapiens_hsa043300.29325767
76Hematopoietic cell lineage_Homo sapiens_hsa046400.28957419
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27994014
78Viral myocarditis_Homo sapiens_hsa054160.27758591
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27310781
80Proteasome_Homo sapiens_hsa030500.26901716
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.26675385
82Nitrogen metabolism_Homo sapiens_hsa009100.26329468
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24579404
84Inositol phosphate metabolism_Homo sapiens_hsa005620.23496571
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23386504
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23199077
87Galactose metabolism_Homo sapiens_hsa000520.22827963
88ECM-receptor interaction_Homo sapiens_hsa045120.22280376
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22043144
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.21533174
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21275221
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.20656960
93Asthma_Homo sapiens_hsa053100.20517230
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19886500
95Dorso-ventral axis formation_Homo sapiens_hsa043200.19309605
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.18650970
97Renal cell carcinoma_Homo sapiens_hsa052110.18220532
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17762449
99Vitamin B6 metabolism_Homo sapiens_hsa007500.17118420
100Purine metabolism_Homo sapiens_hsa002300.16910507
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16836747
102Tight junction_Homo sapiens_hsa045300.16822008
103Platelet activation_Homo sapiens_hsa046110.16801290
104AMPK signaling pathway_Homo sapiens_hsa041520.16668933
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.16401488
106B cell receptor signaling pathway_Homo sapiens_hsa046620.15978394
107Pyruvate metabolism_Homo sapiens_hsa006200.15509090
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15449272
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.15024263
110Arginine biosynthesis_Homo sapiens_hsa002200.14149381
111Pentose phosphate pathway_Homo sapiens_hsa000300.14022772
112HIF-1 signaling pathway_Homo sapiens_hsa040660.13847022
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13749024
114Autoimmune thyroid disease_Homo sapiens_hsa053200.13694909
115Allograft rejection_Homo sapiens_hsa053300.13362803
116Glucagon signaling pathway_Homo sapiens_hsa049220.13133417
117Measles_Homo sapiens_hsa051620.12796917
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.12725214
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12128470
120Acute myeloid leukemia_Homo sapiens_hsa052210.11911765
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.11549942
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11044272
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.09622177
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.07605869
125Huntingtons disease_Homo sapiens_hsa050160.07448822
126Influenza A_Homo sapiens_hsa051640.07405727
127ErbB signaling pathway_Homo sapiens_hsa040120.07236398
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.06103182

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