HIST1H2BM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)9.84340055
2protoporphyrinogen IX biosynthetic process (GO:0006782)8.89238178
3DNA replication-dependent nucleosome organization (GO:0034723)7.65604653
4DNA replication-dependent nucleosome assembly (GO:0006335)7.65604653
5antibacterial humoral response (GO:0019731)7.53959233
6* nucleosome assembly (GO:0006334)7.34940905
7innate immune response in mucosa (GO:0002227)7.28194942
8chromatin assembly (GO:0031497)7.23875337
9antimicrobial humoral response (GO:0019730)7.01866216
10erythrocyte maturation (GO:0043249)6.43180700
11porphyrin-containing compound biosynthetic process (GO:0006779)6.40888934
12* nucleosome organization (GO:0034728)6.39486831
13* protein-DNA complex assembly (GO:0065004)6.17165043
14mitotic chromosome condensation (GO:0007076)5.91350199
15sister chromatid segregation (GO:0000819)5.83035742
16regulation of histone H3-K9 methylation (GO:0051570)5.80857197
17mucosal immune response (GO:0002385)5.68961784
18regulation of DNA endoreduplication (GO:0032875)5.63655953
19tetrapyrrole biosynthetic process (GO:0033014)5.62996722
20heme biosynthetic process (GO:0006783)5.62199146
21* protein-DNA complex subunit organization (GO:0071824)5.56030420
22hemoglobin metabolic process (GO:0020027)5.53944421
23protein localization to kinetochore (GO:0034501)5.50505376
24chromatin assembly or disassembly (GO:0006333)5.50046847
25mitotic sister chromatid segregation (GO:0000070)5.48820721
26organ or tissue specific immune response (GO:0002251)5.37629892
27microtubule depolymerization (GO:0007019)5.29342990
28DNA unwinding involved in DNA replication (GO:0006268)5.12875292
29protein localization to chromosome, centromeric region (GO:0071459)5.10985261
30regulation of response to osmotic stress (GO:0047484)4.98692824
31DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.96885353
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.93795725
33kinetochore organization (GO:0051383)4.85870993
34negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.80523297
35nuclear pore complex assembly (GO:0051292)4.76618148
36erythrocyte development (GO:0048821)4.75235045
37porphyrin-containing compound metabolic process (GO:0006778)4.72722081
38nuclear pore organization (GO:0006999)4.68260869
39positive regulation of mitotic sister chromatid separation (GO:1901970)4.67283782
40positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.67283782
41positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.67283782
42regulation of centriole replication (GO:0046599)4.61958203
43response to methylmercury (GO:0051597)4.47226679
44DNA damage response, signal transduction resulting in transcription (GO:0042772)4.41532377
45meiotic chromosome segregation (GO:0045132)4.37886792
46mitotic sister chromatid cohesion (GO:0007064)4.35290245
47attachment of spindle microtubules to kinetochore (GO:0008608)4.33105813
48positive regulation of chromosome segregation (GO:0051984)4.20139300
49regulation of sister chromatid cohesion (GO:0007063)4.07488688
50heme metabolic process (GO:0042168)4.06108414
51regulation of centrosome cycle (GO:0046605)3.99769419
52CENP-A containing nucleosome assembly (GO:0034080)3.98586999
53regulation of centrosome duplication (GO:0010824)3.94268215
54DNA replication initiation (GO:0006270)3.92440765
55regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.91474611
56response to insecticide (GO:0017085)3.89930225
57chromatin remodeling at centromere (GO:0031055)3.89389130
58chromosome condensation (GO:0030261)3.86979087
59protein K6-linked ubiquitination (GO:0085020)3.78396748
60regulation of megakaryocyte differentiation (GO:0045652)3.78053696
61viral mRNA export from host cell nucleus (GO:0046784)3.73034472
62regulation of sister chromatid segregation (GO:0033045)3.72613012
63regulation of mitotic sister chromatid separation (GO:0010965)3.72613012
64regulation of mitotic sister chromatid segregation (GO:0033047)3.72613012
65negative regulation of chromosome segregation (GO:0051985)3.72322579
66DNA replication-independent nucleosome assembly (GO:0006336)3.69071890
67DNA replication-independent nucleosome organization (GO:0034724)3.69071890
68ATP-dependent chromatin remodeling (GO:0043044)3.69061982
69regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.69016422
70response to lead ion (GO:0010288)3.68744391
71negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.64800664
72negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.64800664
73negative regulation of mitotic sister chromatid segregation (GO:0033048)3.64800664
74negative regulation of mitotic sister chromatid separation (GO:2000816)3.64800664
75negative regulation of sister chromatid segregation (GO:0033046)3.64800664
76telomere maintenance (GO:0000723)3.63601702
77telomere organization (GO:0032200)3.61924868
78mitotic nuclear envelope disassembly (GO:0007077)3.61133364
79mitotic metaphase plate congression (GO:0007080)3.58768304
80protein localization to chromosome (GO:0034502)3.58615553
81spindle checkpoint (GO:0031577)3.58151888
82DNA strand elongation involved in DNA replication (GO:0006271)3.56999984
83pore complex assembly (GO:0046931)3.55934303
84mitotic spindle assembly checkpoint (GO:0007094)3.55237206
85chromosome segregation (GO:0007059)3.54878539
86non-recombinational repair (GO:0000726)3.53965542
87double-strand break repair via nonhomologous end joining (GO:0006303)3.53965542
88metaphase plate congression (GO:0051310)3.53912725
89kinetochore assembly (GO:0051382)3.51821662
90spindle assembly checkpoint (GO:0071173)3.50031981
91erythrocyte differentiation (GO:0030218)3.47622346
92mitotic spindle checkpoint (GO:0071174)3.47175847
93mitotic recombination (GO:0006312)3.46564511
94V(D)J recombination (GO:0033151)3.46250616
95pre-miRNA processing (GO:0031054)3.46001456
96DNA strand elongation (GO:0022616)3.42356864
97membrane disassembly (GO:0030397)3.40418995
98nuclear envelope disassembly (GO:0051081)3.40418995
99establishment of chromosome localization (GO:0051303)3.39638954
100telomere maintenance via semi-conservative replication (GO:0032201)3.39590771
101DNA geometric change (GO:0032392)3.38981665
102DNA duplex unwinding (GO:0032508)3.37941082
103negative regulation of histone methylation (GO:0031061)3.36385905
104negative regulation of DNA repair (GO:0045738)3.36085372
105DNA topological change (GO:0006265)3.34820865
106histone exchange (GO:0043486)3.34255505
107regulation of spindle organization (GO:0090224)3.32191984
108folic acid-containing compound biosynthetic process (GO:0009396)3.32105366
109DNA packaging (GO:0006323)3.29588660
110translesion synthesis (GO:0019985)3.29325899
111DNA replication checkpoint (GO:0000076)3.28378158
112dosage compensation (GO:0007549)3.26424106
113DNA ligation (GO:0006266)3.25108833
114regulation of chromosome segregation (GO:0051983)3.23734260
115positive regulation of histone methylation (GO:0031062)3.21185405
116postreplication repair (GO:0006301)3.17695954
117microtubule polymerization or depolymerization (GO:0031109)3.17339125
118DNA synthesis involved in DNA repair (GO:0000731)3.16894911
119regulation of mitotic metaphase/anaphase transition (GO:0030071)3.15861441
120telomere maintenance via telomere lengthening (GO:0010833)3.13581497
121myeloid cell development (GO:0061515)3.12988166
122cytoskeletal anchoring at plasma membrane (GO:0007016)3.11772611
123telomere maintenance via recombination (GO:0000722)3.11657975
124response to arsenic-containing substance (GO:0046685)3.11313964
125regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.06965961
126DNA conformation change (GO:0071103)3.06794208
127regulation of gene silencing (GO:0060968)3.06392130
128establishment of integrated proviral latency (GO:0075713)3.03861837
129negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.98525639
130nucleotide-excision repair, DNA gap filling (GO:0006297)2.95555236
131deoxyribonucleotide biosynthetic process (GO:0009263)2.95496981
132somatic hypermutation of immunoglobulin genes (GO:0016446)2.92060134
133somatic diversification of immune receptors via somatic mutation (GO:0002566)2.92060134
134somatic cell DNA recombination (GO:0016444)2.91333046
135somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.91333046

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.69244681
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.02602607
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.05909351
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.55912474
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11798275
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.02472948
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.76946118
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.61478088
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.38998693
10* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.38927292
11* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.32667840
12* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.32339187
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20204163
14* SOX2_16153702_ChIP-ChIP_HESCs_Human2.19177135
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse14.0753836
16RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.94296745
17AR_21909140_ChIP-Seq_LNCAP_Human1.86562879
18GATA1_22025678_ChIP-Seq_K562_Human1.86055995
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.77157863
20NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72338911
21* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.71069503
22ESR1_15608294_ChIP-ChIP_MCF-7_Human1.69877927
23POU5F1_16153702_ChIP-ChIP_HESCs_Human1.65841970
24GATA1_19941826_ChIP-Seq_K562_Human1.59895139
25SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.57094568
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.49872709
27IRF1_19129219_ChIP-ChIP_H3396_Human1.46699441
28* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46352516
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41582866
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.39566897
31HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.39548995
32* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37319389
33ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35957865
34SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34319300
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33707858
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25969264
37* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24923553
38KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.20448568
39* VDR_23849224_ChIP-Seq_CD4+_Human1.17408922
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.16771574
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16653544
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15473283
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15273836
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15064833
45GATA1_19941827_ChIP-Seq_MEL_Mouse1.11353260
46SCL_19346495_ChIP-Seq_HPC-7_Human1.11022666
47MYC_22102868_ChIP-Seq_BL_Human1.10318314
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07514521
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07199246
50NANOG_16153702_ChIP-ChIP_HESCs_Human1.05712680
51ELK1_19687146_ChIP-ChIP_HELA_Human1.05322191
52* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04142789
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02548232
54* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00737387
55* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.00564790
56* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99006593
57GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97685113
58* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96531557
59STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91901202
60ETS1_22383799_ChIP-Seq_G1ME_Mouse0.90741887
61VDR_21846776_ChIP-Seq_THP-1_Human0.89435676
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.88843980
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87575821
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85910899
65RBPJ_22232070_ChIP-Seq_NCS_Mouse0.83972886
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.83339375
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.83323530
68GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82796409
69MYC_18940864_ChIP-ChIP_HL60_Human0.81818940
70EST1_17652178_ChIP-ChIP_JURKAT_Human0.79916219
71* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.79647647
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.79616060
73GATA2_19941826_ChIP-Seq_K562_Human0.77390177
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77287739
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76767241
76* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.75483446
77DCP1A_22483619_ChIP-Seq_HELA_Human0.75236977
78NANOG_18555785_ChIP-Seq_MESCs_Mouse0.74389325
79* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.73333594
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.73117808
81EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.72603298
82PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71936942
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.68893442
84RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.68764649
85SALL1_21062744_ChIP-ChIP_HESCs_Human0.67815245
86MYCN_18555785_ChIP-Seq_MESCs_Mouse0.67610842
87KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.66518197
88FOXP3_21729870_ChIP-Seq_TREG_Human0.64824934
89GABP_17652178_ChIP-ChIP_JURKAT_Human0.63880369
90MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.63861164
91ETS1_20019798_ChIP-Seq_JURKAT_Human0.63425166
92XRN2_22483619_ChIP-Seq_HELA_Human0.61987766
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.61762229
94NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.61561545
95PKCTHETA_26484144_Chip-Seq_BREAST_Human0.60216422
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.60139324
97SALL4_22934838_ChIP-ChIP_CD34+_Human0.60086552
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.59801591
99ZFX_18555785_ChIP-Seq_MESCs_Mouse0.59693416
100CREB1_15753290_ChIP-ChIP_HEK293T_Human0.59167460
101MAF_26560356_Chip-Seq_TH1_Human0.58922248
102UTX_26944678_Chip-Seq_JUKART_Human0.58895401
103ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.58542877
104JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.58411021
105ZNF263_19887448_ChIP-Seq_K562_Human0.58296303
106NOTCH1_21737748_ChIP-Seq_TLL_Human0.57039132
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.56911091
108* SOX17_20123909_ChIP-Seq_XEN_Mouse0.56600102
109YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.56354565
110CIITA_25753668_ChIP-Seq_RAJI_Human0.56155948
111TTF2_22483619_ChIP-Seq_HELA_Human0.55952836
112* NANOG_21062744_ChIP-ChIP_HESCs_Human0.55319302
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.55272398
114TCF7_22412390_ChIP-Seq_EML_Mouse0.54590602
115RUNX1_22412390_ChIP-Seq_EML_Mouse0.53298491
116KDM5A_27292631_Chip-Seq_BREAST_Human0.52775366
117ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.48682465
118POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.48648056
119MYB_26560356_Chip-Seq_TH1_Human0.48427553
120FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.47756023
121SOX9_26525672_Chip-Seq_HEART_Mouse0.47281138

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo6.79719077
2MP0004147_increased_porphyrin_level6.68018782
3MP0010094_abnormal_chromosome_stability4.71420609
4MP0003111_abnormal_nucleus_morphology4.35141715
5MP0003077_abnormal_cell_cycle3.71674531
6MP0010307_abnormal_tumor_latency3.42684911
7MP0003693_abnormal_embryo_hatching3.30047836
8MP0008057_abnormal_DNA_replication3.24017686
9MP0004957_abnormal_blastocyst_morpholog2.74273354
10MP0005083_abnormal_biliary_tract2.46451407
11MP0005076_abnormal_cell_differentiation2.32259345
12MP0010352_gastrointestinal_tract_polyps2.30714525
13MP0003941_abnormal_skin_development2.24524157
14MP0000350_abnormal_cell_proliferation2.13590662
15MP0003705_abnormal_hypodermis_morpholog2.11458599
16MP0008058_abnormal_DNA_repair2.08307852
17MP0008877_abnormal_DNA_methylation2.06025948
18MP0006054_spinal_hemorrhage1.94767454
19MP0004808_abnormal_hematopoietic_stem1.88557281
20MP0002396_abnormal_hematopoietic_system1.86273809
21MP0003121_genomic_imprinting1.84519834
22MP0001730_embryonic_growth_arrest1.84341628
23MP0002009_preneoplasia1.83636326
24MP0003123_paternal_imprinting1.80772386
25MP0009697_abnormal_copulation1.75879469
26MP0003763_abnormal_thymus_physiology1.75704644
27MP0008932_abnormal_embryonic_tissue1.72496784
28MP0000490_abnormal_crypts_of1.61244304
29MP0008007_abnormal_cellular_replicative1.56995534
30MP0002086_abnormal_extraembryonic_tissu1.56602541
31MP0002254_reproductive_system_inflammat1.52803053
32MP0004197_abnormal_fetal_growth/weight/1.51741395
33MP0003718_maternal_effect1.51349668
34MP0001697_abnormal_embryo_size1.48695598
35MP0002019_abnormal_tumor_incidence1.46531234
36MP0001661_extended_life_span1.46292247
37MP0001672_abnormal_embryogenesis/_devel1.46205023
38MP0005380_embryogenesis_phenotype1.46205023
39MP0003787_abnormal_imprinting1.46102885
40MP0001545_abnormal_hematopoietic_system1.44022920
41MP0005397_hematopoietic_system_phenotyp1.44022920
42MP0003300_gastrointestinal_ulcer1.42186274
43MP0006035_abnormal_mitochondrial_morpho1.40387287
44MP0000569_abnormal_digit_pigmentation1.40225263
45MP0002080_prenatal_lethality1.34698911
46MP0002166_altered_tumor_susceptibility1.32894500
47MP0003984_embryonic_growth_retardation1.32324925
48MP0002084_abnormal_developmental_patter1.31174032
49MP0002088_abnormal_embryonic_growth/wei1.30685441
50MP0000313_abnormal_cell_death1.27835002
51MP0002398_abnormal_bone_marrow1.26616804
52MP0000358_abnormal_cell_content/1.25373802
53MP0002085_abnormal_embryonic_tissue1.22311841
54MP0000703_abnormal_thymus_morphology1.19853774
55MP0009053_abnormal_anal_canal1.19430548
56MP0006072_abnormal_retinal_apoptosis1.18581901
57MP0010234_abnormal_vibrissa_follicle1.17437868
58MP0002722_abnormal_immune_system1.15427274
59MP0000428_abnormal_craniofacial_morphol1.14993302
60MP0002160_abnormal_reproductive_system1.14760218
61MP0004264_abnormal_extraembryonic_tissu1.12680344
62MP0000537_abnormal_urethra_morphology1.11692235
63MP0002822_catalepsy1.07670392
64MP0003937_abnormal_limbs/digits/tail_de1.06746470
65MP0008770_decreased_survivor_rate1.05483820
66MP0002877_abnormal_melanocyte_morpholog1.05471809
67MP0002006_tumorigenesis1.02408537
68MP0000689_abnormal_spleen_morphology1.02269428
69MP0009703_decreased_birth_body1.01374433
70MP0005501_abnormal_skin_physiology0.97670383
71MP0003950_abnormal_plasma_membrane0.97645301
72MP0002138_abnormal_hepatobiliary_system0.95438615
73MP0009672_abnormal_birth_weight0.93169816
74MP0004185_abnormal_adipocyte_glucose0.92893066
75MP0003786_premature_aging0.89516977
76MP0002429_abnormal_blood_cell0.87973056
77MP0002095_abnormal_skin_pigmentation0.87573333
78MP0001293_anophthalmia0.87449208
79MP0001800_abnormal_humoral_immune0.86308380
80MP0003567_abnormal_fetal_cardiomyocyte0.81419749
81MP0002092_abnormal_eye_morphology0.81076285
82MP0001346_abnormal_lacrimal_gland0.79932930
83MP0001727_abnormal_embryo_implantation0.76752615
84MP0005645_abnormal_hypothalamus_physiol0.76613610
85MP0000733_abnormal_muscle_development0.76469581
86MP0003890_abnormal_embryonic-extraembry0.76014363
87MP0010678_abnormal_skin_adnexa0.75648851
88MP0005621_abnormal_cell_physiology0.74588135
89MP0001348_abnormal_lacrimal_gland0.74422849
90MP0002163_abnormal_gland_morphology0.74334989
91MP0005671_abnormal_response_to0.73904445
92MP0001835_abnormal_antigen_presentation0.73833964
93MP0009931_abnormal_skin_appearance0.72683848
94MP0004233_abnormal_muscle_weight0.72665926
95MP0001216_abnormal_epidermal_layer0.72515282
96MP0005384_cellular_phenotype0.71855085
97MP0002925_abnormal_cardiovascular_devel0.71068245
98MP0004381_abnormal_hair_follicle0.70415259
99MP0002111_abnormal_tail_morphology0.69566694
100MP0000383_abnormal_hair_follicle0.67817764
101MP0002697_abnormal_eye_size0.67765258
102MP0005391_vision/eye_phenotype0.67643511
103MP0001915_intracranial_hemorrhage0.67497436
104MP0001849_ear_inflammation0.67485197
105MP0000685_abnormal_immune_system0.66924700
106MP0001119_abnormal_female_reproductive0.66856365
107MP0002060_abnormal_skin_morphology0.65299817
108MP0001191_abnormal_skin_condition0.65095255
109MP0003566_abnormal_cell_adhesion0.64672003
110MP0005389_reproductive_system_phenotype0.64581199
111MP0005075_abnormal_melanosome_morpholog0.64332590
112MP0000266_abnormal_heart_morphology0.64138429
113MP0005623_abnormal_meninges_morphology0.63444098
114MP0005187_abnormal_penis_morphology0.62489137
115MP0002233_abnormal_nose_morphology0.61619817
116MP0002736_abnormal_nociception_after0.58887457
117MP0010771_integument_phenotype0.57365992
118MP0001286_abnormal_eye_development0.57308630
119MP0009278_abnormal_bone_marrow0.57281308
120MP0000716_abnormal_immune_system0.57223732
121MP0001784_abnormal_fluid_regulation0.56357402
122MP0003303_peritoneal_inflammation0.54632857
123MP0001929_abnormal_gametogenesis0.53622208
124MP0010030_abnormal_orbit_morphology0.53557960
125MP0003448_altered_tumor_morphology0.52942827
126MP0005503_abnormal_tendon_morphology0.52387702
127MP0003315_abnormal_perineum_morphology0.52150271
128MP0000432_abnormal_head_morphology0.51815805
129MP0005023_abnormal_wound_healing0.50676231
130MP0003115_abnormal_respiratory_system0.50579288
131MP0002210_abnormal_sex_determination0.50573808
132MP0001145_abnormal_male_reproductive0.50436235
133MP0009765_abnormal_xenobiotic_induced0.50070365
134MP0000477_abnormal_intestine_morphology0.50026729

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)7.73208656
2Abnormality of the heme biosynthetic pathway (HP:0010472)7.11626799
3Acanthocytosis (HP:0001927)5.97182592
4IgM deficiency (HP:0002850)4.88339043
5Reticulocytosis (HP:0001923)4.78636314
6IgA deficiency (HP:0002720)4.50792514
7Cholelithiasis (HP:0001081)4.48565462
8Diaphragmatic weakness (HP:0009113)4.13059157
9Abnormality of reticulocytes (HP:0004312)4.01578408
10Abnormal gallbladder morphology (HP:0012437)3.93429487
11Insomnia (HP:0100785)3.92008445
12Chromsome breakage (HP:0040012)3.67165931
13Volvulus (HP:0002580)3.62052105
14Hypochromic anemia (HP:0001931)3.55775581
15Colitis (HP:0002583)3.47262862
16Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.42587318
17Short 4th metacarpal (HP:0010044)3.42587318
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.42525158
19Abnormality of chromosome stability (HP:0003220)3.24293413
20Birth length less than 3rd percentile (HP:0003561)3.20464983
21Impulsivity (HP:0100710)3.15294381
22Oral leukoplakia (HP:0002745)3.08181255
23Embryonal renal neoplasm (HP:0011794)3.02269468
24Osteomalacia (HP:0002749)2.93353007
25Abnormality of the fingertips (HP:0001211)2.89113807
26Cutaneous photosensitivity (HP:0000992)2.85337189
27Paralysis (HP:0003470)2.83566922
28Hyperbilirubinemia (HP:0002904)2.80946093
29High pitched voice (HP:0001620)2.79434091
30Abnormality of the gallbladder (HP:0005264)2.78719878
31Gastrointestinal stroma tumor (HP:0100723)2.70832441
32Reticulocytopenia (HP:0001896)2.64586576
33Increased nuchal translucency (HP:0010880)2.61349096
34Clubbing of toes (HP:0100760)2.60913132
35Duodenal stenosis (HP:0100867)2.60111855
36Small intestinal stenosis (HP:0012848)2.60111855
37Agammaglobulinemia (HP:0004432)2.59480841
38Microcytic anemia (HP:0001935)2.57530378
39Basal cell carcinoma (HP:0002671)2.56232439
40Prominent nose (HP:0000448)2.54764630
41Neoplasm of striated muscle (HP:0009728)2.53058929
42Meckel diverticulum (HP:0002245)2.52625541
43Cafe-au-lait spot (HP:0000957)2.45097117
44Abnormality of the labia minora (HP:0012880)2.43904876
45Abnormality of the ileum (HP:0001549)2.38543362
46Ridged nail (HP:0001807)2.37222905
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.34740865
48Abnormality of the 4th metacarpal (HP:0010012)2.33743650
49Renovascular hypertension (HP:0100817)2.33357939
50Lymphoma (HP:0002665)2.33322721
51Neoplasm of the oral cavity (HP:0100649)2.32961279
52Cutaneous melanoma (HP:0012056)2.31365666
53Abnormality of the parietal bone (HP:0002696)2.29403639
54B lymphocytopenia (HP:0010976)2.27874014
55Down-sloping shoulders (HP:0200021)2.25422494
56Lymphopenia (HP:0001888)2.23733779
57Cellulitis (HP:0100658)2.23615731
58Central scotoma (HP:0000603)2.23163555
59Cortical dysplasia (HP:0002539)2.22604345
60Posterior subcapsular cataract (HP:0007787)2.21749364
61Abnormality of the preputium (HP:0100587)2.18559197
62Ectopic kidney (HP:0000086)2.17796956
63Abnormality of the renal collecting system (HP:0004742)2.17644933
64Abnormality of cells of the lymphoid lineage (HP:0012140)2.17344614
65Stenosis of the external auditory canal (HP:0000402)2.13636265
66Long eyelashes (HP:0000527)2.11454810
67Thyroiditis (HP:0100646)2.10010173
68Carpal bone hypoplasia (HP:0001498)2.08754414
69Tracheoesophageal fistula (HP:0002575)2.08011272
70Squamous cell carcinoma (HP:0002860)2.07882993
71Abnormality of DNA repair (HP:0003254)2.06948298
72Hyperacusis (HP:0010780)2.06202174
73Papilledema (HP:0001085)2.06143915
74Deep philtrum (HP:0002002)2.05913913
75Aplasia/Hypoplasia of the sternum (HP:0006714)2.05490381
76Abnormality of the duodenum (HP:0002246)2.04949969
77Medulloblastoma (HP:0002885)2.04909450
78Horseshoe kidney (HP:0000085)2.04140378
79Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03669571
80Short thumb (HP:0009778)2.03658993
81Recurrent sinusitis (HP:0011108)2.02929155
82Abnormality of cochlea (HP:0000375)2.02274120
83Selective tooth agenesis (HP:0001592)2.02236892
84Dry hair (HP:0011359)2.02189603
85Sloping forehead (HP:0000340)2.01630252
86Arteriovenous malformation (HP:0100026)2.01071542
87Poikilocytosis (HP:0004447)10.4472176
88Heterotopia (HP:0002282)1.98155389
89Myelodysplasia (HP:0002863)1.97692122
90Short middle phalanx of the 5th finger (HP:0004220)1.97392560
91Microtia (HP:0008551)1.96356099
92Verrucae (HP:0200043)1.96312860
93Papilloma (HP:0012740)1.96312860
94Milia (HP:0001056)1.95936721
95Hepatocellular carcinoma (HP:0001402)1.95920658
96Progressive muscle weakness (HP:0003323)1.95809758
97Elfin facies (HP:0004428)1.94919121
98Colon cancer (HP:0003003)1.94651067
99Overriding aorta (HP:0002623)1.94638190
100Abnormality of chromosome segregation (HP:0002916)1.94447081
101Proximal placement of thumb (HP:0009623)1.92519797
102Atresia of the external auditory canal (HP:0000413)1.92501042
103Inflammation of the large intestine (HP:0002037)1.92250277
104Prostate neoplasm (HP:0100787)1.91993531
105Deviation of the thumb (HP:0009603)1.91052891
106Ependymoma (HP:0002888)1.91048791
107Macrocytic anemia (HP:0001972)1.90221558
108Hyponatremia (HP:0002902)1.89978489
109Multiple enchondromatosis (HP:0005701)1.89081366
110Rhabdomyosarcoma (HP:0002859)1.88736263
111Abnormal auditory evoked potentials (HP:0006958)1.87637687
112Truncal obesity (HP:0001956)1.86988652
113Progressive external ophthalmoplegia (HP:0000590)1.86827048
114Sandal gap (HP:0001852)1.86403416
115Abnormality of nail color (HP:0100643)1.85468234
116Abnormality of the carotid arteries (HP:0005344)1.82589657
117Missing ribs (HP:0000921)1.82399624
118Subcapsular cataract (HP:0000523)1.81237213
119High anterior hairline (HP:0009890)1.80977423
120Abnormality of cells of the erythroid lineage (HP:0012130)1.80670993
121Cellular immunodeficiency (HP:0005374)1.79886396
122Absent radius (HP:0003974)1.78874177
123Abnormal lung lobation (HP:0002101)1.78340878
12411 pairs of ribs (HP:0000878)1.78239112
125Leukopenia (HP:0001882)1.77493792
126Recurrent viral infections (HP:0004429)1.77426734
127Embryonal neoplasm (HP:0002898)1.77193469
128Cholecystitis (HP:0001082)1.77172949
129Abnormal gallbladder physiology (HP:0012438)1.77172949
130Combined immunodeficiency (HP:0005387)1.77009676
131Agnosia (HP:0010524)1.76535125
132Ovarian neoplasm (HP:0100615)1.76361625
133Patellar aplasia (HP:0006443)1.76335591
134Gastrointestinal inflammation (HP:0004386)1.76298593
135Abnormality of B cell number (HP:0010975)1.74971181
136Absent frontal sinuses (HP:0002688)1.73864731
137External ear malformation (HP:0008572)1.73796598
138Confusion (HP:0001289)1.73595990
139Absent thumb (HP:0009777)1.71595002
140Entropion (HP:0000621)1.71094808
141Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70923066
142Abnormal number of incisors (HP:0011064)1.70830725
143Aplasia involving forearm bones (HP:0009822)1.70722023
144Absent forearm bone (HP:0003953)1.70722023
145Malignant gastrointestinal tract tumors (HP:0006749)1.70605057
146Gastrointestinal carcinoma (HP:0002672)1.70605057
147Astrocytoma (HP:0009592)1.70450371
148Abnormality of the astrocytes (HP:0100707)1.70450371
149Abnormality of sodium homeostasis (HP:0010931)1.70400728
150Ankyloglossia (HP:0010296)1.69827824
151Poikiloderma (HP:0001029)1.68749980
152Nephroblastoma (Wilms tumor) (HP:0002667)1.66811764
153Macroorchidism (HP:0000053)1.66723291
154Abnormal number of erythroid precursors (HP:0012131)1.66346405
155Aplasia/Hypoplasia of the patella (HP:0006498)1.63226412
156Biliary tract neoplasm (HP:0100574)1.63142192
157Trigonocephaly (HP:0000243)1.59516502
158Ulnar bowing (HP:0003031)1.59248378
159Pancreatic islet-cell hyperplasia (HP:0004510)1.57757942
160Long clavicles (HP:0000890)1.57701774
161Glioma (HP:0009733)1.55490080

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.22676976
2ZAK6.30997779
3STK44.30032668
4VRK13.72883749
5CDC73.50274858
6CDK123.26184264
7RPS6KA52.83037148
8NEK22.14137198
9EIF2AK12.08174204
10AURKB1.92591136
11MAP3K81.89619951
12PIM11.77704180
13CDK91.72003618
14SCYL21.63606797
15EIF2AK31.55571934
16EEF2K1.48124353
17WEE11.47728321
18CHEK21.44066707
19MAP3K101.39008261
20CAMK1D1.29761930
21DYRK31.28175458
22BRD41.26014336
23TTK1.20593828
24TAF11.20055182
25NEK11.19625622
26CDK61.16224055
27SRPK11.10812030
28PLK11.08340658
29BUB11.06418490
30PRKAA11.04596875
31STK101.04533892
32GRK61.03827299
33PKN11.01097075
34ATR0.99818413
35MST40.98594256
36AURKA0.95112891
37CDK40.94438134
38TSSK60.86078440
39PLK30.85880973
40RPS6KB20.85724674
41STK30.81621311
42BRSK20.80082903
43PASK0.79208639
44CHEK10.79047411
45DYRK1B0.78644252
46SMG10.74899725
47MAP3K90.74401024
48PKN20.73441923
49NME20.72510537
50BRSK10.71075415
51ATM0.70132276
52MELK0.66700993
53STK240.65797328
54CDK20.60321798
55TRPM70.60046424
56CAMK1G0.59023511
57DAPK30.56979865
58CDK70.56357923
59PBK0.54740165
60CDK10.54338682
61AKT20.50082708
62ACVR1B0.50015827
63TTN0.49077758
64MAP2K70.46677854
65LATS10.41230787
66BRAF0.40694696
67CAMK40.40572684
68PRPF4B0.39138580
69BTK0.39093589
70PLK40.38997993
71CSNK1D0.38171676
72EIF2AK20.38115010
73FLT30.37952762
74ERBB20.37573914
75STK38L0.36383275
76STK160.35457715
77LRRK20.32974045
78CCNB10.30597112
79BLK0.30222214
80SGK30.29113565
81MAPK140.28274067
82MTOR0.27430688
83JAK20.27172753
84CDK80.27141838
85FRK0.26828993
86MKNK20.26465509
87PRKCQ0.26228522
88PRKDC0.25204274
89PRKCD0.24740376
90AKT10.23862031
91MAPK110.23611584
92MAP3K40.23068800
93BMPR1B0.22455066
94RPS6KA40.19398280
95NLK0.17616022
96MST1R0.17552462
97ROCK10.17369831
98FGFR20.17033409
99MET0.16987603
100TGFBR10.16901232
101TEC0.16519809
102MAPKAPK30.15856109
103CSNK1G10.15726579
104PAK10.14891697
105* RPS6KA30.13886087
106CDK150.12948848
107BMX0.12626645
108RPS6KB10.12317993
109CLK10.12015903
110SYK0.11875388
111VRK20.11577134
112MAP4K10.11532412
113GSK3B0.10677946
114FGR0.10436369
115NEK90.10392306
116SGK20.10261252
117HIPK20.09797625
118MAPK10.09659215
119CSNK2A20.09620898
120CDK180.09617363
121ICK0.08853262
122MARK30.08315387
123CSNK2A10.07363981
124EPHA20.07172272
125CDK11A0.06592618
126PDGFRA0.05976814
127LYN0.05792233
128CSNK1G30.05219172
129MAPK90.04914095
130CDK190.04422110
131PAK20.03944885

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.56704348
2* Viral carcinogenesis_Homo sapiens_hsa052033.33425219
3DNA replication_Homo sapiens_hsa030302.85977581
4Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.79234121
5Cell cycle_Homo sapiens_hsa041102.37848470
6Mismatch repair_Homo sapiens_hsa034302.27725871
7* Systemic lupus erythematosus_Homo sapiens_hsa0532211.5212788
8Transcriptional misregulation in cancer_Homo sapiens_hsa052021.65715336
9Fanconi anemia pathway_Homo sapiens_hsa034601.64624886
10One carbon pool by folate_Homo sapiens_hsa006701.61989070
11Base excision repair_Homo sapiens_hsa034101.56374149
12Non-homologous end-joining_Homo sapiens_hsa034501.46043163
13Nucleotide excision repair_Homo sapiens_hsa034201.45672605
14Homologous recombination_Homo sapiens_hsa034401.40727072
15RNA transport_Homo sapiens_hsa030131.26996877
16p53 signaling pathway_Homo sapiens_hsa041151.13934832
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00376865
18Spliceosome_Homo sapiens_hsa030400.98968168
19Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92749769
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90584360
21MicroRNAs in cancer_Homo sapiens_hsa052060.87882217
22mRNA surveillance pathway_Homo sapiens_hsa030150.86792758
23Oocyte meiosis_Homo sapiens_hsa041140.85370927
24Small cell lung cancer_Homo sapiens_hsa052220.84691919
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83583713
26Malaria_Homo sapiens_hsa051440.81367934
27Ribosome_Homo sapiens_hsa030100.80739891
28Non-small cell lung cancer_Homo sapiens_hsa052230.80672383
29Chronic myeloid leukemia_Homo sapiens_hsa052200.73210879
30Hematopoietic cell lineage_Homo sapiens_hsa046400.70388628
31Herpes simplex infection_Homo sapiens_hsa051680.66603880
32HTLV-I infection_Homo sapiens_hsa051660.63391970
33Bladder cancer_Homo sapiens_hsa052190.63243670
34Selenocompound metabolism_Homo sapiens_hsa004500.61349245
35Pyrimidine metabolism_Homo sapiens_hsa002400.61235619
36Dorso-ventral axis formation_Homo sapiens_hsa043200.58645206
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54196584
38Pancreatic cancer_Homo sapiens_hsa052120.52713951
39Hepatitis B_Homo sapiens_hsa051610.52317141
40Prostate cancer_Homo sapiens_hsa052150.51270782
41Lysine degradation_Homo sapiens_hsa003100.51133186
42RNA degradation_Homo sapiens_hsa030180.51042905
43Apoptosis_Homo sapiens_hsa042100.47527475
44Glioma_Homo sapiens_hsa052140.45779552
45Allograft rejection_Homo sapiens_hsa053300.44634003
46Epstein-Barr virus infection_Homo sapiens_hsa051690.43723296
47Autoimmune thyroid disease_Homo sapiens_hsa053200.42678599
48Antigen processing and presentation_Homo sapiens_hsa046120.40741302
49FoxO signaling pathway_Homo sapiens_hsa040680.38024141
50Proteasome_Homo sapiens_hsa030500.37696272
51Vitamin B6 metabolism_Homo sapiens_hsa007500.36933105
52Sulfur relay system_Homo sapiens_hsa041220.36219697
53Asthma_Homo sapiens_hsa053100.35859608
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33605840
55Graft-versus-host disease_Homo sapiens_hsa053320.31959581
56Measles_Homo sapiens_hsa051620.31925693
57mTOR signaling pathway_Homo sapiens_hsa041500.31181801
58Pentose phosphate pathway_Homo sapiens_hsa000300.30974456
59TGF-beta signaling pathway_Homo sapiens_hsa043500.30186786
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30060040
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30031587
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29847201
63Colorectal cancer_Homo sapiens_hsa052100.29692097
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28984408
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27990224
66Melanoma_Homo sapiens_hsa052180.27589145
67Thyroid cancer_Homo sapiens_hsa052160.26422597
68Proteoglycans in cancer_Homo sapiens_hsa052050.25270954
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.25218528
70Endometrial cancer_Homo sapiens_hsa052130.22915621
71Type I diabetes mellitus_Homo sapiens_hsa049400.22128021
72ABC transporters_Homo sapiens_hsa020100.21527635
73AMPK signaling pathway_Homo sapiens_hsa041520.21447984
74Hedgehog signaling pathway_Homo sapiens_hsa043400.21421497
75B cell receptor signaling pathway_Homo sapiens_hsa046620.19990889
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19397382
77RNA polymerase_Homo sapiens_hsa030200.18836372
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17928927
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.17903071
80Basal cell carcinoma_Homo sapiens_hsa052170.17613486
81Influenza A_Homo sapiens_hsa051640.17305487
82Pathways in cancer_Homo sapiens_hsa052000.16685198
83Hippo signaling pathway_Homo sapiens_hsa043900.16160222
84Folate biosynthesis_Homo sapiens_hsa007900.15855858
85Adherens junction_Homo sapiens_hsa045200.14880418
86Basal transcription factors_Homo sapiens_hsa030220.14776873
87Carbon metabolism_Homo sapiens_hsa012000.13745091
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12851182
89Purine metabolism_Homo sapiens_hsa002300.12792459
90Inositol phosphate metabolism_Homo sapiens_hsa005620.12665310
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12629690
92Platelet activation_Homo sapiens_hsa046110.12182088
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.11221144
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.10914847
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.10090525
96Primary immunodeficiency_Homo sapiens_hsa053400.09571411
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.09426967
98Renin-angiotensin system_Homo sapiens_hsa046140.09353853
99Notch signaling pathway_Homo sapiens_hsa043300.09076836
100Viral myocarditis_Homo sapiens_hsa054160.08975197
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.08787536
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.08564379
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.08255989
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07978430
105Wnt signaling pathway_Homo sapiens_hsa043100.06947012
106Pyruvate metabolism_Homo sapiens_hsa006200.06935485
107Biosynthesis of amino acids_Homo sapiens_hsa012300.06795710
108Focal adhesion_Homo sapiens_hsa045100.06788571
109HIF-1 signaling pathway_Homo sapiens_hsa040660.06525611
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.06395952
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.06164237
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.05657423
113ECM-receptor interaction_Homo sapiens_hsa045120.05466945
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.04851345
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.04804980
116Huntingtons disease_Homo sapiens_hsa050160.04596111
117Leishmaniasis_Homo sapiens_hsa051400.04285971
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.04130500
119N-Glycan biosynthesis_Homo sapiens_hsa005100.03906799
120Toxoplasmosis_Homo sapiens_hsa051450.03605765
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.03424511
122Glutathione metabolism_Homo sapiens_hsa004800.02517847
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.01670105
124ErbB signaling pathway_Homo sapiens_hsa040120.01612297
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.01391465
126Fructose and mannose metabolism_Homo sapiens_hsa000510.01128365

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