ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fatty acid elongation (GO:0030497)	7.35690704
2	negative regulation of mast cell activation (GO:0033004)	5.42975371
3	DNA deamination (GO:0045006)	5.04972560
4	innate immune response in mucosa (GO:0002227)	4.71689427
5	growth hormone receptor signaling pathway (GO:0060396)	4.68817296
6	negative regulation of leukocyte chemotaxis (GO:0002689)	4.63618452
7	xenobiotic catabolic process (GO:0042178)	4.57790078
8	erythrocyte maturation (GO:0043249)	4.41660035
9	protein neddylation (GO:0045116)	4.27458174
10	cellular response to growth hormone stimulus (GO:0071378)	4.25204368
11	response to misfolded protein (GO:0051788)	4.18027634
12	beta-amyloid metabolic process (GO:0050435)	4.15919921
13	negative regulation of B cell apoptotic process (GO:0002903)	4.14517551
14	immunoglobulin mediated immune response (GO:0016064)	4.00585291
15	regulation of memory T cell differentiation (GO:0043380)	4.00076418
16	interleukin-6-mediated signaling pathway (GO:0070102)	3.95981506
17	mucosal immune response (GO:0002385)	3.90261709
18	negative regulation of JAK-STAT cascade (GO:0046426)	3.88282748
19	regulation of macrophage chemotaxis (GO:0010758)	3.85788474
20	fusion of sperm to egg plasma membrane (GO:0007342)	3.80184952
21	granulocyte differentiation (GO:0030851)	3.79305777
22	response to nitrosative stress (GO:0051409)	3.69115294
23	mast cell activation involved in immune response (GO:0002279)	3.60696292
24	mast cell degranulation (GO:0043303)	3.60696292
25	multicellular organism reproduction (GO:0032504)	3.60397847
26	organ or tissue specific immune response (GO:0002251)	3.57300963
27	positive regulation of protein homodimerization activity (GO:0090073)	3.55469706
28	adenosine metabolic process (GO:0046085)	3.53087228
29	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)	3.50899547
30	B cell mediated immunity (GO:0019724)	3.49827164
31	purinergic nucleotide receptor signaling pathway (GO:0035590)	3.49266760
32	antibacterial humoral response (GO:0019731)	3.48249600
33	cell fate commitment involved in formation of primary germ layer (GO:0060795)	3.42214655
34	determination of adult lifespan (GO:0008340)	3.39911327
35	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.38395804
36	cullin deneddylation (GO:0010388)	3.38012837
37	platelet dense granule organization (GO:0060155)	3.31943910
38	fucose catabolic process (GO:0019317)	3.29706953
39	L-fucose metabolic process (GO:0042354)	3.29706953
40	L-fucose catabolic process (GO:0042355)	3.29706953
41	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.29540236
42	negative regulation of protein oligomerization (GO:0032460)	3.28722872
43	histone H2A acetylation (GO:0043968)	3.28323000
44	tyrosine phosphorylation of STAT protein (GO:0007260)	3.26827747
45	meiotic chromosome segregation (GO:0045132)	3.22431006
46	replication fork processing (GO:0031297)	3.22352421
47	regulation of B cell apoptotic process (GO:0002902)	3.14788170
48	mannosylation (GO:0097502)	3.12927198
49	negative regulation of histone acetylation (GO:0035067)	3.05421743
50	neuronal action potential propagation (GO:0019227)	3.05172914
51	antimicrobial humoral response (GO:0019730)	3.04874124
52	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.99520952
53	branched-chain amino acid catabolic process (GO:0009083)	2.98774916
54	peptide catabolic process (GO:0043171)	2.98682928
55	regulation of cellular amino acid metabolic process (GO:0006521)	2.95146318
56	negative regulation of viral entry into host cell (GO:0046597)	2.93743834
57	response to growth hormone (GO:0060416)	2.93329491
58	regulation of autophagic vacuole assembly (GO:2000785)	2.92419227
59	negative regulation of T-helper cell differentiation (GO:0045623)	2.84937339
60	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.84937339
61	protein deneddylation (GO:0000338)	2.83448615
62	dopamine transport (GO:0015872)	2.83440946
63	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.83317079
64	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.82728936
65	regulation of heat generation (GO:0031650)	2.82271373
66	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.81042717
67	negative regulation of alpha-beta T cell differentiation (GO:0046639)	2.80769311
68	regulation of thymocyte apoptotic process (GO:0070243)	2.79139412
69	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.77740524
70	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.77740524
71	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.77740524
72	nucleosome assembly (GO:0006334)	2.77362143
73	response to interferon-beta (GO:0035456)	2.76895137
74	plasma membrane fusion (GO:0045026)	2.75003753
75	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.72381970
76	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.72381970
77	negative regulation of actin filament bundle assembly (GO:0032232)	2.70878129
78	hormone catabolic process (GO:0042447)	2.70600886
79	ubiquinone biosynthetic process (GO:0006744)	2.70127603
80	regulation of antigen processing and presentation (GO:0002577)	2.69537514
81	fatty-acyl-CoA biosynthetic process (GO:0046949)	2.69351162
82	sulfation (GO:0051923)	2.68445267
83	male meiosis (GO:0007140)	2.68321178
84	mast cell activation (GO:0045576)	2.68297753
85	positive regulation of ligase activity (GO:0051351)	2.68234798
86	cytidine deamination (GO:0009972)	2.67810590
87	cytidine metabolic process (GO:0046087)	2.67810590
88	cytidine catabolic process (GO:0006216)	2.67810590
89	negative regulation of thymocyte apoptotic process (GO:0070244)	2.65881915
90	autophagic vacuole fusion (GO:0000046)	2.65849414
91	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	2.63855599
92	regulation of vacuole organization (GO:0044088)	2.63831319
93	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.63458145
94	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.62399505
95	histone H2B ubiquitination (GO:0033523)	2.62041010
96	regulation of protein homooligomerization (GO:0032462)	2.61824161
97	urate metabolic process (GO:0046415)	2.61355701
98	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.59761972
99	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	2.59512908
100	positive regulation of response to oxidative stress (GO:1902884)	2.59117117

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.57323258
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.76157654
3	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.39323401
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.09118140
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.03691761
6	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.87511980
7	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.87169878
8	IRF1_19129219_ChIP-ChIP_H3396_Human	2.82676294
9	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.82501529
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.75405674
11	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.67157921
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.62729118
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.45805632
14	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.21915212
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.07875119
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.06494161
17	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.00864825
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.00806832
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.99335033
20	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.96193617
21	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.95293202
22	VDR_22108803_ChIP-Seq_LS180_Human	1.89972995
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.84429615
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.78365212
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.78216568
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.76019532
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.75526826
28	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.75377726
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.69969062
30	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.69885978
31	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.68712934
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.65870868
33	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.65162357
34	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.63532738
35	E2F7_22180533_ChIP-Seq_HELA_Human	1.61648548
36	ELK1_19687146_ChIP-ChIP_HELA_Human	1.59771479
37	SPI1_23127762_ChIP-Seq_K562_Human	1.59614567
38	EZH2_22144423_ChIP-Seq_EOC_Human	1.58060326
39	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.57801353
40	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.54319586
41	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.50829629
42	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.49971616
43	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.47133573
44	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43878921
45	EWS_26573619_Chip-Seq_HEK293_Human	1.43640353
46	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.43549404
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.43366967
48	CIITA_25753668_ChIP-Seq_RAJI_Human	1.34461274
49	GATA3_26560356_Chip-Seq_TH2_Human	1.31749754
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30584819
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30584819
52	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.29110973
53	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.28304123
54	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.27914190
55	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26355981
56	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.26268936
57	GATA3_27048872_Chip-Seq_THYMUS_Human	1.25541244
58	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24424095
59	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.23898169
60	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.23623482
61	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.20467286
62	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.19845396
63	ETS1_22383799_ChIP-Seq_G1ME_Mouse	1.17930272
64	STAT1_20625510_ChIP-Seq_HELA_Human	1.17670848
65	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.15868095
66	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.13151561
67	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.13150294
68	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.12508887
69	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.11954327
70	ER_23166858_ChIP-Seq_MCF-7_Human	1.11768771
71	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.11268641
72	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.10849308
73	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.10677123
74	HTT_18923047_ChIP-ChIP_STHdh_Human	1.10488708
75	FUS_26573619_Chip-Seq_HEK293_Human	1.09080864
76	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.05768316
77	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.04736371
78	SCL_19346495_ChIP-Seq_HPC-7_Human	1.04334060
79	GATA1_19941826_ChIP-Seq_K562_Human	1.03439986
80	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.02979555
81	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.02408545
82	FOXP3_21729870_ChIP-Seq_TREG_Human	1.01749299
83	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.01634480
84	NANOG_20526341_ChIP-Seq_ESCs_Human	1.01315061
85	RBPJ_21746931_ChIP-Seq_IB4_Human	1.01236527
86	AR_20517297_ChIP-Seq_VCAP_Human	1.01087337
87	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.00261359
88	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.99275749
89	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.98599186
90	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.98333414
91	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.97544378
92	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.96175118
93	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.96062544
94	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.95913452
95	PHF8_20622853_ChIP-Seq_HELA_Human	0.95628218
96	HOXB7_26014856_ChIP-Seq_BT474_Human	0.95566927
97	AR_25329375_ChIP-Seq_VCAP_Human	0.93555148
98	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.92867148
99	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.92788083
100	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.92544040

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002138_abnormal_hepatobiliary_system	6.29405477
2	MP0005464_abnormal_platelet_physiology	3.90103147
3	MP0001835_abnormal_antigen_presentation	3.14484842
4	MP0006054_spinal_hemorrhage	2.97128670
5	MP0008875_abnormal_xenobiotic_pharmacok	2.91012856
6	MP0006292_abnormal_olfactory_placode	2.68256242
7	MP0008872_abnormal_physiological_respon	2.58236933
8	MP0000613_abnormal_salivary_gland	2.52859337
9	MP0002166_altered_tumor_susceptibility	2.52692447
10	MP0008995_early_reproductive_senescence	2.50350119
11	MP0000647_abnormal_sebaceous_gland	2.49734771
12	MP0005075_abnormal_melanosome_morpholog	2.40585256
13	MP0000383_abnormal_hair_follicle	2.30260088
14	MP0005167_abnormal_blood-brain_barrier	2.28011107
15	MP0008004_abnormal_stomach_pH	2.22323817
16	MP0005645_abnormal_hypothalamus_physiol	2.06310675
17	MP0000685_abnormal_immune_system	1.98762267
18	MP0005671_abnormal_response_to	1.89041497
19	MP0000465_gastrointestinal_hemorrhage	1.83891855
20	MP0003806_abnormal_nucleotide_metabolis	1.80413529
21	MP0003724_increased_susceptibility_to	1.73154541
22	MP0000427_abnormal_hair_cycle	1.66484424
23	MP0002006_tumorigenesis	1.65544179
24	MP0003011_delayed_dark_adaptation	1.62184076
25	MP0005646_abnormal_pituitary_gland	1.59730091
26	MP0003646_muscle_fatigue	1.58545129
27	MP0001853_heart_inflammation	1.54480578
28	MP0001873_stomach_inflammation	1.53418873
29	MP0004742_abnormal_vestibular_system	1.52723443
30	MP0009053_abnormal_anal_canal	1.51398819
31	MP0001727_abnormal_embryo_implantation	1.50943435
32	MP0005551_abnormal_eye_electrophysiolog	1.47252848
33	MP0002282_abnormal_trachea_morphology	1.42410751
34	MP0009697_abnormal_copulation	1.42179898
35	MP0010678_abnormal_skin_adnexa	1.39562723
36	MP0005410_abnormal_fertilization	1.38090795
37	MP0003786_premature_aging	1.36942445
38	MP0005360_urolithiasis	1.35092953
39	MP0008932_abnormal_embryonic_tissue	1.33418793
40	MP0004947_skin_inflammation	1.25816137
41	MP0004043_abnormal_pH_regulation	1.23678343
42	MP0008058_abnormal_DNA_repair	1.22425147
43	MP0001800_abnormal_humoral_immune	1.21715012
44	MP0005000_abnormal_immune_tolerance	1.19844741
45	MP0005310_abnormal_salivary_gland	1.18592550
46	MP0004381_abnormal_hair_follicle	1.17059447
47	MP0002398_abnormal_bone_marrow	1.15645778
48	MP0002638_abnormal_pupillary_reflex	1.13842367
49	MP0003879_abnormal_hair_cell	1.13611793
50	MP0004147_increased_porphyrin_level	1.12697802
51	MP0000689_abnormal_spleen_morphology	1.11867407
52	MP0002102_abnormal_ear_morphology	1.11136727
53	MP0003718_maternal_effect	1.05871951
54	MP0008775_abnormal_heart_ventricle	1.02437196
55	MP0005387_immune_system_phenotype	1.01468688
56	MP0001790_abnormal_immune_system	1.01468688
57	MP0006036_abnormal_mitochondrial_physio	0.99025630
58	MP0002148_abnormal_hypersensitivity_rea	0.97984945
59	MP0008789_abnormal_olfactory_epithelium	0.95244091
60	MP0002722_abnormal_immune_system	0.94367300
61	MP0002452_abnormal_antigen_presenting	0.93243729
62	MP0002723_abnormal_immune_serum	0.93050199
63	MP0005535_abnormal_body_temperature	0.92192530
64	MP0005220_abnormal_exocrine_pancreas	0.92175965
65	MP0001545_abnormal_hematopoietic_system	0.92128987
66	MP0005397_hematopoietic_system_phenotyp	0.92128987
67	MP0009764_decreased_sensitivity_to	0.91156904
68	MP0009785_altered_susceptibility_to	0.90502461
69	MP0004084_abnormal_cardiac_muscle	0.87897733
70	MP0005332_abnormal_amino_acid	0.87050858
71	MP0003186_abnormal_redox_activity	0.85292891
72	MP0002210_abnormal_sex_determination	0.85292533
73	MP0000343_altered_response_to	0.84887937
74	MP0003656_abnormal_erythrocyte_physiolo	0.84609204
75	MP0005379_endocrine/exocrine_gland_phen	0.84000214
76	MP0002429_abnormal_blood_cell	0.82291704
77	MP0004510_myositis	0.82154990
78	MP0002420_abnormal_adaptive_immunity	0.81718065
79	MP0001764_abnormal_homeostasis	0.81377910
80	MP0000230_abnormal_systemic_arterial	0.80500768
81	MP0005389_reproductive_system_phenotype	0.79645303
82	MP0001819_abnormal_immune_cell	0.78621405
83	MP0002751_abnormal_autonomic_nervous	0.78219645
84	MP0002733_abnormal_thermal_nociception	0.76887439
85	MP0002295_abnormal_pulmonary_circulatio	0.76206897
86	MP0001929_abnormal_gametogenesis	0.74393701
87	MP0001501_abnormal_sleep_pattern	0.73059780
88	MP0002736_abnormal_nociception_after	0.73029987
89	MP0001765_abnormal_ion_homeostasis	0.72849718
90	MP0004808_abnormal_hematopoietic_stem	0.72810764
91	MP0001845_abnormal_inflammatory_respons	0.72186733
92	MP0000653_abnormal_sex_gland	0.72033682
93	MP0001919_abnormal_reproductive_system	0.71156978
94	MP0002272_abnormal_nervous_system	0.71008137
95	MP0004142_abnormal_muscle_tone	0.70979522
96	MP0008057_abnormal_DNA_replication	0.70468501
97	MP0010155_abnormal_intestine_physiology	0.70131852
98	MP0009046_muscle_twitch	0.69793818
99	MP0001851_eye_inflammation	0.69024650
100	MP0000716_abnormal_immune_system	0.68252910

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.73261244
2	Petechiae (HP:0000967)	4.69880531
3	Prolonged bleeding time (HP:0003010)	4.56537699
4	Autoamputation (HP:0001218)	4.37860845
5	Elevated erythrocyte sedimentation rate (HP:0003565)	4.06750157
6	Prostate neoplasm (HP:0100787)	3.85575303
7	Acute necrotizing encephalopathy (HP:0006965)	3.56000836
8	Menorrhagia (HP:0000132)	3.18258650
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.17784961
10	Hypomagnesemia (HP:0002917)	3.14128873
11	Acute encephalopathy (HP:0006846)	3.07294427
12	Progressive macrocephaly (HP:0004481)	3.02552391
13	Abnormality of the prostate (HP:0008775)	3.00714319
14	Increased mean platelet volume (HP:0011877)	2.98887300
15	Increased hepatocellular lipid droplets (HP:0006565)	2.96597399
16	Epistaxis (HP:0000421)	2.93305636
17	Purpura (HP:0000979)	2.85694069
18	Abolished electroretinogram (ERG) (HP:0000550)	2.83828922
19	Abnormality of the parathyroid morphology (HP:0011766)	2.80837289
20	Lipid accumulation in hepatocytes (HP:0006561)	2.78833666
21	Type I transferrin isoform profile (HP:0003642)	2.74289756
22	Chronic sinusitis (HP:0011109)	2.72941050
23	Abnormal platelet volume (HP:0011876)	2.72686911
24	Poor speech (HP:0002465)	2.68800042
25	Cerebral edema (HP:0002181)	2.66570688
26	Renal Fanconi syndrome (HP:0001994)	2.62994393
27	Hypoplasia of the fovea (HP:0007750)	2.61866810
28	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.61866810
29	Mitochondrial inheritance (HP:0001427)	2.57376689
30	Dry hair (HP:0011359)	2.53598766
31	Abnormality of alanine metabolism (HP:0010916)	2.53394939
32	Hyperalaninemia (HP:0003348)	2.53394939
33	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.53394939
34	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.49023278
35	Exertional dyspnea (HP:0002875)	2.46241551
36	Congenital, generalized hypertrichosis (HP:0004540)	2.45510565
37	Abnormality of magnesium homeostasis (HP:0004921)	2.44107067
38	Increased CSF lactate (HP:0002490)	2.41205610
39	Increased intramyocellular lipid droplets (HP:0012240)	2.34821911
40	Increased serum lactate (HP:0002151)	2.33445991
41	Pancreatic fibrosis (HP:0100732)	2.33361633
42	Large eyes (HP:0001090)	2.30274467
43	Abnormal glycosylation (HP:0012345)	2.30065245
44	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.30065245
45	Abnormal protein N-linked glycosylation (HP:0012347)	2.30065245
46	Abnormal protein glycosylation (HP:0012346)	2.30065245
47	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.29471999
48	Abnormality of midbrain morphology (HP:0002418)	2.29187310
49	Molar tooth sign on MRI (HP:0002419)	2.29187310
50	Clubbing of toes (HP:0100760)	2.26896820
51	Chronic otitis media (HP:0000389)	2.18927378
52	Polyuria (HP:0000103)	2.15289844
53	Attenuation of retinal blood vessels (HP:0007843)	2.13971808
54	Poikilocytosis (HP:0004447)	2.12018149
55	True hermaphroditism (HP:0010459)	2.11922184
56	Medial flaring of the eyebrow (HP:0010747)	2.09043979
57	Abnormality of the fovea (HP:0000493)	2.06915041
58	Cerebellar dysplasia (HP:0007033)	2.05070630
59	Hypokalemic alkalosis (HP:0001949)	1.99442934
60	Osteomyelitis (HP:0002754)	1.99248822
61	Type II lissencephaly (HP:0007260)	1.99144881
62	Fair hair (HP:0002286)	1.96764577
63	Recurrent sinusitis (HP:0011108)	1.96177491
64	Hyperlipoproteinemia (HP:0010980)	1.94070982
65	Lethargy (HP:0001254)	1.93822591
66	Impaired platelet aggregation (HP:0003540)	1.92472084
67	Abnormal platelet function (HP:0011869)	1.92472084
68	Retinal dysplasia (HP:0007973)	1.92304385
69	Osteolytic defects of the hand bones (HP:0009699)	1.91982041
70	Osteolytic defects of the phalanges of the hand (HP:0009771)	1.91982041
71	Pancreatic cysts (HP:0001737)	1.88550277
72	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.87833572
73	Lactic acidosis (HP:0003128)	1.87773248
74	Increased muscle lipid content (HP:0009058)	1.87311787
75	Generalized aminoaciduria (HP:0002909)	1.87017485
76	Metabolic alkalosis (HP:0200114)	1.85184372
77	Amblyopia (HP:0000646)	1.84040101
78	Abnormality of the fingertips (HP:0001211)	1.83544630
79	Alkalosis (HP:0001948)	1.81505961
80	Hyperventilation (HP:0002883)	1.79658902
81	Gingival bleeding (HP:0000225)	1.79531006
82	Congenital stationary night blindness (HP:0007642)	1.78477583
83	Pachygyria (HP:0001302)	1.76090575
84	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.75394668
85	Poor head control (HP:0002421)	1.74785454
86	Abnormality of lateral ventricle (HP:0030047)	1.74272634
87	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.74068832
88	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.73545986
89	Methylmalonic acidemia (HP:0002912)	1.72583209
90	Abnormal urine output (HP:0012590)	1.71694998
91	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.70587077
92	Opisthotonus (HP:0002179)	1.70267235
93	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.70175185
94	Ridged nail (HP:0001807)	1.69214047
95	Erythema (HP:0010783)	1.68788587
96	Abnormality of B cell number (HP:0010975)	1.67514609
97	Squamous cell carcinoma (HP:0002860)	1.65190203
98	Optic disc pallor (HP:0000543)	1.65166842
99	Azoospermia (HP:0000027)	1.64322810
100	Autoimmune hemolytic anemia (HP:0001890)	1.64068595

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BRSK2	6.97100220
2	ZAK	4.31810733
3	WEE1	3.97137094
4	TLK1	3.88980298
5	MST4	3.44935943
6	VRK2	2.86690031
7	BRSK1	2.84696198
8	NUAK1	2.71191379
9	VRK1	2.57089243
10	EIF2AK1	2.38786636
11	FRK	2.19724979
12	FER	1.89089284
13	KIT	1.88608627
14	BMPR1B	1.82430223
15	TAF1	1.73711993
16	PDK2	1.72736827
17	MKNK2	1.66226131
18	ADRBK2	1.64812752
19	PBK	1.53336850
20	ACVR1B	1.53146443
21	PINK1	1.45239745
22	PNCK	1.44917523
23	GRK5	1.30098453
24	MAPKAPK3	1.29106093
25	RIPK4	1.26811735
26	SMG1	1.25211637
27	PKN1	1.15470047
28	SYK	1.11735251
29	CAMK1G	1.09580498
30	CDK8	1.04212632
31	PIK3CG	1.00197846
32	PLK2	0.99856453
33	DAPK3	0.98999459
34	RPS6KA5	0.88498607
35	MAPKAPK5	0.87996175
36	WNK4	0.85872671
37	STK4	0.83773139
38	CDK4	0.82867507
39	PLK4	0.82580014
40	IKBKB	0.81524423
41	MYLK	0.79864199
42	AURKA	0.78505015
43	PLK3	0.77333202
44	MARK3	0.76476201
45	MKNK1	0.75175841
46	EIF2AK2	0.72616700
47	WNK3	0.72393285
48	MAPK13	0.69776021
49	CHEK2	0.68895978
50	GRK1	0.67978520
51	ATR	0.66611249
52	CAMKK2	0.65293526
53	ERBB3	0.64209845
54	ADRBK1	0.63007566
55	BCKDK	0.59697653
56	MAP4K1	0.57633750
57	CSF1R	0.57326197
58	GRK7	0.55081213
59	LYN	0.53784480
60	PTK2B	0.52888335
61	IRAK1	0.51711720
62	KDR	0.50808341
63	CAMK1	0.50106328
64	PLK1	0.49676058
65	TEC	0.49208718
66	CDC7	0.49124873
67	PRKAA1	0.48754967
68	CSNK1G3	0.47389917
69	IKBKE	0.45741307
70	CSNK1G1	0.42410502
71	CDK9	0.42126235
72	MAP4K2	0.40793650
73	FLT3	0.39738542
74	BTK	0.38220197
75	PIM1	0.38037616
76	STK3	0.37739877
77	STK24	0.37719583
78	TYRO3	0.37633676
79	CDK3	0.36298812
80	DAPK1	0.34585722
81	BMPR2	0.33932060
82	JAK3	0.32681570
83	TRIM28	0.30428378
84	DYRK2	0.29801406
85	NME1	0.29659070
86	HIPK2	0.29083691
87	IRAK2	0.28123273
88	PRKCA	0.26830420
89	ILK	0.25740778
90	SIK3	0.25137723
91	BMX	0.24414097
92	EPHA3	0.23656816
93	PHKG2	0.23315453
94	PHKG1	0.23315453
95	EPHB2	0.22898474
96	PRKG1	0.22832416
97	AURKB	0.22475500
98	CSNK1G2	0.22399517
99	TAOK3	0.22367205
100	MAP3K10	0.22082140

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus_Homo sapiens_hsa05322	6.00112628
2	Asthma_Homo sapiens_hsa05310	3.51695347
3	Alcoholism_Homo sapiens_hsa05034	3.49189528
4	Allograft rejection_Homo sapiens_hsa05330	3.24831876
5	Proteasome_Homo sapiens_hsa03050	3.22856022
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.04562050
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.99967322
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.98549987
9	Fatty acid elongation_Homo sapiens_hsa00062	2.98117564
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.34536974
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.31381081
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.25607775
13	Antigen processing and presentation_Homo sapiens_hsa04612	1.91655286
14	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.84384988
15	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.73155694
16	Viral carcinogenesis_Homo sapiens_hsa05203	1.71294034
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.69953883
18	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.60459551
19	RNA polymerase_Homo sapiens_hsa03020	1.60285107
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.49735365
21	Viral myocarditis_Homo sapiens_hsa05416	1.45231017
22	Propanoate metabolism_Homo sapiens_hsa00640	1.37312900
23	Mismatch repair_Homo sapiens_hsa03430	1.33730555
24	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.33365694
25	Rheumatoid arthritis_Homo sapiens_hsa05323	1.28406868
26	Primary immunodeficiency_Homo sapiens_hsa05340	1.17772111
27	Oxidative phosphorylation_Homo sapiens_hsa00190	1.17668384
28	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.17621983
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.14915865
30	Regulation of autophagy_Homo sapiens_hsa04140	1.13968982
31	Olfactory transduction_Homo sapiens_hsa04740	1.13550791
32	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.11872181
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.11779505
34	Homologous recombination_Homo sapiens_hsa03440	1.10400395
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.07424294
36	Leishmaniasis_Homo sapiens_hsa05140	1.04629433
37	Collecting duct acid secretion_Homo sapiens_hsa04966	1.04098171
38	Parkinsons disease_Homo sapiens_hsa05012	0.97192913
39	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.95971427
40	Pyruvate metabolism_Homo sapiens_hsa00620	0.95724551
41	Base excision repair_Homo sapiens_hsa03410	0.90528557
42	Glutathione metabolism_Homo sapiens_hsa00480	0.88773894
43	DNA replication_Homo sapiens_hsa03030	0.85940040
44	beta-Alanine metabolism_Homo sapiens_hsa00410	0.84214917
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.81065013
46	Phagosome_Homo sapiens_hsa04145	0.80444239
47	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.78974091
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.78458319
49	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.76486951
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.76224706
51	Protein export_Homo sapiens_hsa03060	0.75848227
52	Butanoate metabolism_Homo sapiens_hsa00650	0.75698820
53	Fatty acid metabolism_Homo sapiens_hsa01212	0.75457020
54	Platelet activation_Homo sapiens_hsa04611	0.74110931
55	Purine metabolism_Homo sapiens_hsa00230	0.72330832
56	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.68847154
57	Herpes simplex infection_Homo sapiens_hsa05168	0.68707025
58	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.68546916
59	ABC transporters_Homo sapiens_hsa02010	0.68273212
60	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.65876083
61	Cell cycle_Homo sapiens_hsa04110	0.63574905
62	Huntingtons disease_Homo sapiens_hsa05016	0.63535289
63	Nucleotide excision repair_Homo sapiens_hsa03420	0.63412283
64	Ether lipid metabolism_Homo sapiens_hsa00565	0.63043599
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.63011969
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61605690
67	p53 signaling pathway_Homo sapiens_hsa04115	0.61015388
68	Sulfur metabolism_Homo sapiens_hsa00920	0.58202933
69	Fatty acid degradation_Homo sapiens_hsa00071	0.54983266
70	Pyrimidine metabolism_Homo sapiens_hsa00240	0.50964846
71	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.50537294
72	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.49410175
73	Selenocompound metabolism_Homo sapiens_hsa00450	0.48793442
74	RNA degradation_Homo sapiens_hsa03018	0.47549675
75	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.45063142
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.44726638
77	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.44296702
78	Phototransduction_Homo sapiens_hsa04744	0.42821408
79	Peroxisome_Homo sapiens_hsa04146	0.40995202
80	Alzheimers disease_Homo sapiens_hsa05010	0.38491531
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38327315
82	Tryptophan metabolism_Homo sapiens_hsa00380	0.38175712
83	RNA transport_Homo sapiens_hsa03013	0.38001971
84	Tuberculosis_Homo sapiens_hsa05152	0.37173053
85	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.36305277
86	Fat digestion and absorption_Homo sapiens_hsa04975	0.31994338
87	Glycerolipid metabolism_Homo sapiens_hsa00561	0.31305531
88	Retinol metabolism_Homo sapiens_hsa00830	0.31152202
89	Arginine and proline metabolism_Homo sapiens_hsa00330	0.30873278
90	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.29076919
91	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.28749398
92	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.27857909
93	Caffeine metabolism_Homo sapiens_hsa00232	0.27832367
94	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.25971724
95	Metabolic pathways_Homo sapiens_hsa01100	0.25579184
96	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.24642229
97	HTLV-I infection_Homo sapiens_hsa05166	0.22980399
98	Serotonergic synapse_Homo sapiens_hsa04726	0.18667737
99	Non-homologous end-joining_Homo sapiens_hsa03450	0.17340496
100	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.17122555

HIST1H2BPS2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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