HIST1H2BPS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)8.47971507
2cytidine metabolic process (GO:0046087)8.47971507
3cytidine catabolic process (GO:0006216)8.47971507
4pyrimidine ribonucleoside catabolic process (GO:0046133)7.20891937
5DNA deamination (GO:0045006)6.87589573
6innate immune response in mucosa (GO:0002227)6.61064508
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.31920980
8mucosal immune response (GO:0002385)5.47759239
9purine-containing compound salvage (GO:0043101)5.40142876
10DNA replication-dependent nucleosome assembly (GO:0006335)5.32224960
11DNA replication-dependent nucleosome organization (GO:0034723)5.32224960
12antibacterial humoral response (GO:0019731)5.19230649
13urate metabolic process (GO:0046415)4.97716395
14organ or tissue specific immune response (GO:0002251)4.94639176
15antimicrobial humoral response (GO:0019730)4.69151729
16activated T cell proliferation (GO:0050798)4.64921471
17production of molecular mediator involved in inflammatory response (GO:0002532)4.63742744
18response to interferon-beta (GO:0035456)4.52523197
19cytolysis (GO:0019835)4.49375565
20inner mitochondrial membrane organization (GO:0007007)4.25171807
21purine nucleotide salvage (GO:0032261)3.97566041
22dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.95195380
23nucleosome assembly (GO:0006334)3.85418958
24GDP-mannose metabolic process (GO:0019673)3.82583904
25regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.74646831
26regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.67869915
27UDP-N-acetylglucosamine metabolic process (GO:0006047)3.63626027
28positive regulation of defense response to virus by host (GO:0002230)3.63366735
29NAD biosynthetic process (GO:0009435)3.60138053
30protein-DNA complex assembly (GO:0065004)3.58475994
31negative regulation of viral genome replication (GO:0045071)3.58005932
32ATP synthesis coupled proton transport (GO:0015986)3.51460696
33energy coupled proton transport, down electrochemical gradient (GO:0015985)3.51460696
34nucleotide-sugar biosynthetic process (GO:0009226)3.47731015
35IMP biosynthetic process (GO:0006188)3.36457623
36mannosylation (GO:0097502)3.34668401
37lipoxygenase pathway (GO:0019372)3.33822416
38viral mRNA export from host cell nucleus (GO:0046784)3.30819330
39defense response to Gram-positive bacterium (GO:0050830)3.26118832
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.23191163
41DNA demethylation (GO:0080111)3.21643670
42GMP metabolic process (GO:0046037)3.18933425
43pyrimidine nucleoside catabolic process (GO:0046135)3.16930501
44cell fate commitment involved in formation of primary germ layer (GO:0060795)3.16648342
45immunoglobulin mediated immune response (GO:0016064)3.16332118
46guanosine-containing compound biosynthetic process (GO:1901070)3.13396465
47protein homotrimerization (GO:0070207)3.12006038
48positive regulation of T cell mediated cytotoxicity (GO:0001916)3.10777704
49nucleosome organization (GO:0034728)3.06971032
50mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04303738
51mitochondrial respiratory chain complex I assembly (GO:0032981)3.04303738
52NADH dehydrogenase complex assembly (GO:0010257)3.04303738
53N-acetylglucosamine metabolic process (GO:0006044)2.99940247
54positive regulation of interferon-alpha production (GO:0032727)2.97812865
55protein complex biogenesis (GO:0070271)2.97066759
56DNA dealkylation (GO:0035510)2.96390644
57negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.95084132
58protein-DNA complex subunit organization (GO:0071824)2.94231514
59protein neddylation (GO:0045116)2.91724134
60protein maturation by protein folding (GO:0022417)2.91297892
61negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.86810122
62mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.85694570
63antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.85551256
64GTP biosynthetic process (GO:0006183)2.84937548
65positive regulation of B cell differentiation (GO:0045579)2.84601537
66regulation of cellular amino acid metabolic process (GO:0006521)2.83960085
67cornea development in camera-type eye (GO:0061303)2.83404589
68positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83028451
69leukotriene biosynthetic process (GO:0019370)2.82913351
70pyrimidine ribonucleoside metabolic process (GO:0046131)2.82381519
71DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.82293067
72negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.82190153
73establishment of protein localization to mitochondrial membrane (GO:0090151)2.82125558
74chromatin assembly (GO:0031497)2.81552810
75positive regulation of alpha-beta T cell differentiation (GO:0046638)2.81276870
76cell wall macromolecule catabolic process (GO:0016998)2.79716887
77negative regulation of ligase activity (GO:0051352)2.77818908
78negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.77818908
79intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.77082085
80signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.77082085
81nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.76718585
82regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.76648778
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.75755600
84signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.75359342
85signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.75359342
86signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.75359342
87regulation of interferon-alpha production (GO:0032647)2.74264948
88ncRNA 3-end processing (GO:0043628)2.73690141
89signal transduction involved in DNA integrity checkpoint (GO:0072401)2.73673937
90signal transduction involved in DNA damage checkpoint (GO:0072422)2.73673937
91purine nucleobase biosynthetic process (GO:0009113)2.72650767
92lysine metabolic process (GO:0006553)2.71837170
93lysine catabolic process (GO:0006554)2.71837170
94purine nucleobase metabolic process (GO:0006144)2.69834532
95signal transduction involved in cell cycle checkpoint (GO:0072395)2.67608177
96histone mRNA metabolic process (GO:0008334)2.66102284
97RNA destabilization (GO:0050779)2.65617094
98antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.64155190
99pyridine nucleotide biosynthetic process (GO:0019363)2.63619635
100nicotinamide nucleotide biosynthetic process (GO:0019359)2.63619635

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.17946957
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.42700022
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.17840749
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.86432261
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.38759546
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.16084645
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.91027835
8STAT4_19710469_ChIP-ChIP_TH1__Mouse2.78135534
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.75112973
10HOXB4_20404135_ChIP-ChIP_EML_Mouse2.54607585
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.48787046
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.33662300
13E2F7_22180533_ChIP-Seq_HELA_Human2.31970911
14SOX2_16153702_ChIP-ChIP_HESCs_Human2.30689171
15POU5F1_16153702_ChIP-ChIP_HESCs_Human2.29403839
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.24738392
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.24060792
18PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse2.22854504
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.21507035
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21068826
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.19866811
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.18357354
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17505210
24VDR_23849224_ChIP-Seq_CD4+_Human2.12565473
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08844395
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.07457721
27SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.02290695
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00162030
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.00023320
30ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.91991259
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.91029926
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.90578823
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.89180436
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85191677
35HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.81258905
36FOXP3_21729870_ChIP-Seq_TREG_Human1.80571195
37CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.80347092
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79135940
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.70905250
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.65981435
41MYC_18940864_ChIP-ChIP_HL60_Human1.61400375
42CIITA_25753668_ChIP-Seq_RAJI_Human1.58984255
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53180162
44ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52413701
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48290361
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48169452
47NANOG_16153702_ChIP-ChIP_HESCs_Human1.47321008
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.44885874
49EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.44725521
50MYC_18555785_ChIP-Seq_MESCs_Mouse1.43873546
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42659256
52VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.40444157
53ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.37154076
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36525649
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34630902
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33847995
57KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.33477279
58PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.33436950
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32821118
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32654097
61DCP1A_22483619_ChIP-Seq_HELA_Human1.30440741
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30190639
63IRF1_19129219_ChIP-ChIP_H3396_Human1.29101109
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29029318
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28136546
66BCL6_27268052_Chip-Seq_Bcells_Human1.23229822
67MYB_26560356_Chip-Seq_TH2_Human1.23202297
68RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.21434778
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.20912020
70TDRD3_21172665_ChIP-Seq_MCF-7_Human1.20732340
71SPI1_20517297_ChIP-Seq_HL60_Human1.18653896
72YY1_22570637_ChIP-Seq_MALME-3M_Human1.18601666
73IRF8_21731497_ChIP-ChIP_J774_Mouse1.18296114
74TAF2_19829295_ChIP-Seq_ESCs_Human1.17542306
75BCOR_27268052_Chip-Seq_Bcells_Human1.16239389
76ELK1_19687146_ChIP-ChIP_HELA_Human1.15053131
77P300_27268052_Chip-Seq_Bcells_Human1.10496218
78XRN2_22483619_ChIP-Seq_HELA_Human1.09291127
79PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09004244
80SOX2_18692474_ChIP-Seq_MESCs_Mouse1.06851471
81GATA3_27048872_Chip-Seq_THYMUS_Human1.03608983
82ETS1_22383799_ChIP-Seq_G1ME_Mouse1.02069620
83E2F1_20622854_ChIP-Seq_HELA_Human1.02013994
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99766088
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99378757
86NOTCH1_21737748_ChIP-Seq_TLL_Human0.96623314
87GABP_19822575_ChIP-Seq_HepG2_Human0.96381628
88RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95522793
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94413493
90AR_20517297_ChIP-Seq_VCAP_Human0.90812872
91FOXA1_25329375_ChIP-Seq_VCAP_Human0.90266399
92FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90266399
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88799376
94YY1_21170310_ChIP-Seq_MESCs_Mouse0.86028889
95GATA3_26560356_Chip-Seq_TH2_Human0.85528345
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84954498
97GATA3_21878914_ChIP-Seq_MCF-7_Human0.83428976
98THAP11_20581084_ChIP-Seq_MESCs_Mouse0.83191337
99E2F1_21310950_ChIP-Seq_MCF-7_Human0.82776484
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82734488

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.81727127
2MP0005360_urolithiasis3.83566290
3MP0003950_abnormal_plasma_membrane3.45012589
4MP0003763_abnormal_thymus_physiology3.40432228
5MP0008057_abnormal_DNA_replication3.20837028
6MP0001835_abnormal_antigen_presentation3.19666611
7MP0008058_abnormal_DNA_repair3.15493459
8MP0009780_abnormal_chondrocyte_physiolo3.03110816
9MP0002138_abnormal_hepatobiliary_system2.65394133
10MP0003436_decreased_susceptibility_to2.58092446
11MP0002090_abnormal_vision2.36298989
12MP0002254_reproductive_system_inflammat2.27714278
13MP0002876_abnormal_thyroid_physiology2.19078404
14MP0005000_abnormal_immune_tolerance2.17783513
15MP0009333_abnormal_splenocyte_physiolog2.16347691
16MP0002736_abnormal_nociception_after2.06888178
17MP0010094_abnormal_chromosome_stability2.03918966
18MP0005167_abnormal_blood-brain_barrier2.03271011
19MP0003111_abnormal_nucleus_morphology1.97099580
20MP0008877_abnormal_DNA_methylation1.94197668
21MP0002166_altered_tumor_susceptibility1.93796850
22MP0002420_abnormal_adaptive_immunity1.93762821
23MP0003724_increased_susceptibility_to1.92746754
24MP0001800_abnormal_humoral_immune1.91025464
25MP0002148_abnormal_hypersensitivity_rea1.90237775
26MP0005646_abnormal_pituitary_gland1.85643149
27MP0001819_abnormal_immune_cell1.84186644
28MP0000372_irregular_coat_pigmentation1.80856367
29MP0001529_abnormal_vocalization1.71485813
30MP0009785_altered_susceptibility_to1.67101056
31MP0005645_abnormal_hypothalamus_physiol1.64184585
32MP0002723_abnormal_immune_serum1.60443320
33MP0005410_abnormal_fertilization1.57868201
34MP0001533_abnormal_skeleton_physiology1.56119770
35MP0005387_immune_system_phenotype1.55082037
36MP0001790_abnormal_immune_system1.55082037
37MP0002419_abnormal_innate_immunity1.53756280
38MP0003866_abnormal_defecation1.51529909
39MP0008875_abnormal_xenobiotic_pharmacok1.47685862
40MP0006082_CNS_inflammation1.47672066
41MP0002452_abnormal_antigen_presenting1.46937219
42MP0002006_tumorigenesis1.46599474
43MP0002722_abnormal_immune_system1.45535047
44MP0005025_abnormal_response_to1.44734773
45MP0001968_abnormal_touch/_nociception1.44397806
46MP0000716_abnormal_immune_system1.39147442
47MP0001919_abnormal_reproductive_system1.37739344
48MP0000703_abnormal_thymus_morphology1.35870851
49MP0000685_abnormal_immune_system1.35708864
50MP0001346_abnormal_lacrimal_gland1.33880492
51MP0010155_abnormal_intestine_physiology1.33155279
52MP0001502_abnormal_circadian_rhythm1.32176191
53MP0001348_abnormal_lacrimal_gland1.31175652
54MP0002398_abnormal_bone_marrow1.30501923
55MP0004233_abnormal_muscle_weight1.26052633
56MP0002938_white_spotting1.24341788
57MP0000689_abnormal_spleen_morphology1.21268515
58MP0002429_abnormal_blood_cell1.16596721
59MP0000613_abnormal_salivary_gland1.15607164
60MP0006292_abnormal_olfactory_placode1.14804105
61MP0002277_abnormal_respiratory_mucosa1.06171174
62MP0003195_calcinosis1.05093315
63MP0000490_abnormal_crypts_of1.03683158
64MP0000747_muscle_weakness1.02121284
65MP0003786_premature_aging0.99443993
66MP0001764_abnormal_homeostasis0.98831975
67MP0009643_abnormal_urine_homeostasis0.95786497
68MP0002160_abnormal_reproductive_system0.95451494
69MP0001845_abnormal_inflammatory_respons0.94869329
70MP0005389_reproductive_system_phenotype0.92725265
71MP0008469_abnormal_protein_level0.92162796
72MP0006072_abnormal_retinal_apoptosis0.90822953
73MP0006035_abnormal_mitochondrial_morpho0.89916084
74MP0000358_abnormal_cell_content/0.89002208
75MP0001853_heart_inflammation0.88471746
76MP0003693_abnormal_embryo_hatching0.88434398
77MP0005165_increased_susceptibility_to0.86273169
78MP0002210_abnormal_sex_determination0.84786768
79MP0000566_synostosis0.84615517
80MP0003806_abnormal_nucleotide_metabolis0.83787116
81MP0001873_stomach_inflammation0.83690730
82MP0009763_increased_sensitivity_to0.82602514
83MP0001145_abnormal_male_reproductive0.82266497
84MP0005390_skeleton_phenotype0.81777602
85MP0002909_abnormal_adrenal_gland0.80543736
86MP0005253_abnormal_eye_physiology0.79862784
87MP0005551_abnormal_eye_electrophysiolog0.78954696
88MP0004957_abnormal_blastocyst_morpholog0.78092332
89MP0000639_abnormal_adrenal_gland0.77319904
90MP0001501_abnormal_sleep_pattern0.76951814
91MP0005266_abnormal_metabolism0.75826430
92MP0001929_abnormal_gametogenesis0.74567932
93MP0008872_abnormal_physiological_respon0.74544640
94MP0000653_abnormal_sex_gland0.71625835
95MP0001905_abnormal_dopamine_level0.71025412
96MP0009764_decreased_sensitivity_to0.69725584
97MP0005464_abnormal_platelet_physiology0.69152657
98MP0009765_abnormal_xenobiotic_induced0.68988244
99MP0004147_increased_porphyrin_level0.68806852
100MP0005332_abnormal_amino_acid0.68424180

Predicted human phenotypes

RankGene SetZ-score
1Visual hallucinations (HP:0002367)7.41108263
2Increased neuronal autofluorescent lipopigment (HP:0002074)7.36885372
3Spastic diplegia (HP:0001264)6.71343211
4Autoimmune hemolytic anemia (HP:0001890)6.57614536
5Autoimmune thrombocytopenia (HP:0001973)6.51843185
6Increased cerebral lipofuscin (HP:0011813)6.31949784
7Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)6.17793007
8Tetraparesis (HP:0002273)5.90246158
9Testicular atrophy (HP:0000029)5.65999350
10Abnormality of T cell physiology (HP:0011840)4.64300878
11Recurrent viral infections (HP:0004429)4.45422047
12Prostate neoplasm (HP:0100787)4.42200844
13Abnormality of T cells (HP:0002843)4.13926885
14Abnormality of the prostate (HP:0008775)4.09981325
15Recurrent cutaneous fungal infections (HP:0011370)3.96389263
16Chronic mucocutaneous candidiasis (HP:0002728)3.96389263
17Panhypogammaglobulinemia (HP:0003139)3.87061173
18Dyschromatopsia (HP:0007641)3.72684934
193-Methylglutaconic aciduria (HP:0003535)3.29184563
20Opisthotonus (HP:0002179)3.21401772
21Abnormality of purine metabolism (HP:0004352)3.17118351
22Aplastic anemia (HP:0001915)2.86725849
23Central scotoma (HP:0000603)2.83820100
24Abnormal delayed hypersensitivity skin test (HP:0002963)2.83444672
25Agammaglobulinemia (HP:0004432)2.79329515
26Acute necrotizing encephalopathy (HP:0006965)2.75043757
27Abnormal mitochondria in muscle tissue (HP:0008316)2.71849185
28T lymphocytopenia (HP:0005403)2.70211971
29Abnormality of male internal genitalia (HP:0000022)2.63446406
30Type I transferrin isoform profile (HP:0003642)2.63034429
31Recurrent fungal infections (HP:0002841)2.53938327
32Congenital, generalized hypertrichosis (HP:0004540)2.52475846
33Gout (HP:0001997)2.49088014
34Abnormality of lateral ventricle (HP:0030047)2.45605861
35Oral leukoplakia (HP:0002745)2.43975291
36Hypoproteinemia (HP:0003075)2.43851566
37Mitochondrial inheritance (HP:0001427)2.38737070
38Hypobetalipoproteinemia (HP:0003563)2.37708665
39Rimmed vacuoles (HP:0003805)2.34006668
40Parakeratosis (HP:0001036)2.32594838
41Increased CSF lactate (HP:0002490)2.31726278
42Abnormality of T cell number (HP:0011839)2.31312463
43Lymphopenia (HP:0001888)2.29043762
44Acute encephalopathy (HP:0006846)2.28843316
45Progressive sensorineural hearing impairment (HP:0000408)2.28713284
46Dysautonomia (HP:0002459)2.21682688
47Lymphoma (HP:0002665)2.21024492
48Encephalitis (HP:0002383)2.20628615
49Recurrent lower respiratory tract infections (HP:0002783)2.19673390
50Cerebral hypomyelination (HP:0006808)2.19289680
51Cerebral edema (HP:0002181)2.09231748
52Progressive macrocephaly (HP:0004481)2.05881834
53Hepatocellular necrosis (HP:0001404)2.05870997
54Abnormality of nucleobase metabolism (HP:0010932)2.00596444
55Abnormal protein glycosylation (HP:0012346)2.00201897
56Abnormal glycosylation (HP:0012345)2.00201897
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00201897
58Abnormal protein N-linked glycosylation (HP:0012347)2.00201897
59Abnormality of cells of the lymphoid lineage (HP:0012140)1.96624562
60Abnormality of the nasal septum (HP:0000419)1.92962614
61IgG deficiency (HP:0004315)1.92090645
62Hypoplasia of the uterus (HP:0000013)1.91112641
63Sparse eyelashes (HP:0000653)1.87897087
64Dry hair (HP:0011359)1.87433087
65Skin rash (HP:0000988)1.86980620
66Amniotic constriction ring (HP:0009775)1.86892729
67Abnormality of placental membranes (HP:0011409)1.86892729
68Recurrent skin infections (HP:0001581)1.86246062
69Vasculitis (HP:0002633)1.84473286
70Nausea (HP:0002018)1.82601691
71Cerebral palsy (HP:0100021)1.81918201
72Rough bone trabeculation (HP:0100670)1.81173840
73Neutropenia (HP:0001875)1.76350572
74Severe combined immunodeficiency (HP:0004430)1.76336249
75Short clavicles (HP:0000894)1.76219198
76Decreased activity of mitochondrial respiratory chain (HP:0008972)1.74712817
77Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.74712817
78Hepatic necrosis (HP:0002605)1.74462250
79Pancytopenia (HP:0001876)1.73742710
80B lymphocytopenia (HP:0010976)1.71898483
81Steatorrhea (HP:0002570)1.71202660
82Congenital stationary night blindness (HP:0007642)1.71144059
83Lethargy (HP:0001254)1.64362808
84Pulmonary fibrosis (HP:0002206)1.63541587
85Meningitis (HP:0001287)1.63438816
86Combined immunodeficiency (HP:0005387)1.62454100
87Lactic acidosis (HP:0003128)1.62075469
88Aplasia/hypoplasia of the uterus (HP:0008684)1.61763220
89Increased serum lactate (HP:0002151)1.59615124
90Aplasia/Hypoplasia of the clavicles (HP:0006710)1.59043082
91Reduced antithrombin III activity (HP:0001976)1.56559265
92Humeroradial synostosis (HP:0003041)1.56024901
93Synostosis involving the elbow (HP:0003938)1.56024901
94Dicarboxylic aciduria (HP:0003215)1.55757241
95Abnormality of dicarboxylic acid metabolism (HP:0010995)1.55757241
96Ridged nail (HP:0001807)1.52530235
97Hepatosplenomegaly (HP:0001433)1.50008829
98Attenuation of retinal blood vessels (HP:0007843)1.49973937
99Decreased central vision (HP:0007663)1.49531527
100Hypoalbuminemia (HP:0003073)1.49376266

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK16.91172070
2ZAK6.18624054
3VRK14.21623093
4BMPR1B4.16705925
5BCKDK3.78380818
6TXK3.20415162
7MAP4K13.15770433
8BUB12.85275766
9CDK82.77161463
10NEK12.54828470
11VRK22.03078598
12RPS6KA51.76575082
13TESK21.74542804
14AURKA1.64709479
15DAPK31.63471982
16KDR1.59056164
17TGFBR11.56464111
18KIT1.52613603
19GRK11.48879045
20SMG11.35358635
21MAP4K21.25774338
22MAPKAPK31.13744301
23ADRBK21.11867335
24CDK91.08574672
25TAOK31.06086731
26MAP2K71.04267956
27CHEK21.02319501
28STK41.00738725
29MST1R0.96500870
30MET0.91415891
31BMPR20.89943404
32MAP3K110.87196849
33NME20.86952520
34LYN0.86768907
35GRK70.86489016
36RPS6KB20.86017526
37AURKB0.85511073
38SYK0.84661794
39ITK0.79531121
40WEE10.79159268
41EIF2AK30.73495306
42TAF10.73475644
43FES0.72785600
44TBK10.69157560
45BTK0.68391551
46IKBKB0.64051949
47RIPK40.63830983
48PLK20.60691505
49CAMK2D0.58575111
50MAPKAPK50.58388936
51PKN10.58087875
52PRKCD0.56900488
53JAK30.53374824
54TYRO30.50642918
55ABL20.50301869
56RPS6KB10.49479283
57GSK3A0.48393309
58CDC70.42969699
59TNK20.42323188
60ZAP700.41920693
61CSNK1A1L0.38870527
62CAMK2G0.37898593
63PRKCQ0.37442424
64CSNK1A10.35734512
65GRK50.34763394
66CSNK1G30.33855338
67TESK10.33723272
68EPHA40.33515084
69IKBKE0.33399133
70FLT30.33140815
71CSNK2A20.32494530
72PIM10.32283776
73EIF2AK20.31444571
74PNCK0.31216940
75PAK10.30856383
76CSK0.30468599
77LCK0.30372986
78PLK30.29443894
79PRKCB0.29199496
80CSNK2A10.28725440
81CSF1R0.27863607
82PLK10.27760964
83LRRK20.27604310
84IGF1R0.27530060
85CDK70.27513363
86AKT20.27053668
87ATR0.24353505
88PLK40.23191357
89ADRBK10.22878176
90FYN0.21551034
91DAPK10.19998007
92MAP2K20.19964116
93MYLK0.19931166
94EEF2K0.19162049
95PDK20.18290437
96MAPK90.18051670
97PRKCI0.17662554
98GRK60.17130582
99ATM0.17032098
100MAPK70.16194468

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053228.51952069
2Alcoholism_Homo sapiens_hsa050345.42244320
3Proteasome_Homo sapiens_hsa030503.30330140
4Antigen processing and presentation_Homo sapiens_hsa046122.62857330
5Viral carcinogenesis_Homo sapiens_hsa052032.54256260
6Allograft rejection_Homo sapiens_hsa053302.30030174
7Primary immunodeficiency_Homo sapiens_hsa053402.17108441
8Graft-versus-host disease_Homo sapiens_hsa053322.07390000
9Autoimmune thyroid disease_Homo sapiens_hsa053202.00022233
10Asthma_Homo sapiens_hsa053101.92628020
11Type I diabetes mellitus_Homo sapiens_hsa049401.81571433
12Oxidative phosphorylation_Homo sapiens_hsa001901.79738196
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.77498610
14DNA replication_Homo sapiens_hsa030301.75157525
15Parkinsons disease_Homo sapiens_hsa050121.71812414
16Spliceosome_Homo sapiens_hsa030401.63746892
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.55515557
18Transcriptional misregulation in cancer_Homo sapiens_hsa052021.53086548
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.48130247
20Mismatch repair_Homo sapiens_hsa034301.42935139
21Ribosome_Homo sapiens_hsa030101.39709368
22RNA polymerase_Homo sapiens_hsa030201.38105886
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30328530
24Huntingtons disease_Homo sapiens_hsa050161.27034853
25Alzheimers disease_Homo sapiens_hsa050101.08909313
26Pyrimidine metabolism_Homo sapiens_hsa002401.07380324
27N-Glycan biosynthesis_Homo sapiens_hsa005101.03113984
28Homologous recombination_Homo sapiens_hsa034400.99328328
29Fatty acid elongation_Homo sapiens_hsa000620.98389693
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98363091
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95252802
32Nitrogen metabolism_Homo sapiens_hsa009100.92718333
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90655115
34Cardiac muscle contraction_Homo sapiens_hsa042600.88921565
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88829862
36Rheumatoid arthritis_Homo sapiens_hsa053230.88161176
37Viral myocarditis_Homo sapiens_hsa054160.85044768
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84830111
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82014799
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80801262
41Nucleotide excision repair_Homo sapiens_hsa034200.80223189
42Sulfur metabolism_Homo sapiens_hsa009200.78003280
43Base excision repair_Homo sapiens_hsa034100.76074861
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74915557
45Hematopoietic cell lineage_Homo sapiens_hsa046400.72887156
46RNA transport_Homo sapiens_hsa030130.72593469
47Staphylococcus aureus infection_Homo sapiens_hsa051500.71578499
48Steroid biosynthesis_Homo sapiens_hsa001000.71061058
49Renin-angiotensin system_Homo sapiens_hsa046140.69444570
50Herpes simplex infection_Homo sapiens_hsa051680.68254992
51Protein export_Homo sapiens_hsa030600.66710872
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66082072
53Non-homologous end-joining_Homo sapiens_hsa034500.61399024
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60105727
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59263009
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58961500
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58729382
58Purine metabolism_Homo sapiens_hsa002300.57675966
59Basal transcription factors_Homo sapiens_hsa030220.56265225
60RNA degradation_Homo sapiens_hsa030180.56182587
61Glutathione metabolism_Homo sapiens_hsa004800.51967283
62Selenocompound metabolism_Homo sapiens_hsa004500.51828192
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51709325
64Legionellosis_Homo sapiens_hsa051340.50199555
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50144915
66mRNA surveillance pathway_Homo sapiens_hsa030150.49564339
67Fanconi anemia pathway_Homo sapiens_hsa034600.49255705
68Caffeine metabolism_Homo sapiens_hsa002320.48172621
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47069945
70Linoleic acid metabolism_Homo sapiens_hsa005910.46524997
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44995078
72Leishmaniasis_Homo sapiens_hsa051400.43485023
73Tryptophan metabolism_Homo sapiens_hsa003800.42971434
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41356282
75Fat digestion and absorption_Homo sapiens_hsa049750.40745102
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38204845
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37374480
78Ether lipid metabolism_Homo sapiens_hsa005650.36400113
79Metabolic pathways_Homo sapiens_hsa011000.35845665
80HTLV-I infection_Homo sapiens_hsa051660.34120742
81Regulation of autophagy_Homo sapiens_hsa041400.34036848
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33453581
83Mineral absorption_Homo sapiens_hsa049780.32518844
84Pentose phosphate pathway_Homo sapiens_hsa000300.31973639
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30911581
86Phototransduction_Homo sapiens_hsa047440.30905667
87Propanoate metabolism_Homo sapiens_hsa006400.30686175
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.30443154
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.29273445
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27281424
91Butanoate metabolism_Homo sapiens_hsa006500.27133689
92Chemical carcinogenesis_Homo sapiens_hsa052040.26985029
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26834642
94Fatty acid degradation_Homo sapiens_hsa000710.25352236
95One carbon pool by folate_Homo sapiens_hsa006700.24065502
96Epstein-Barr virus infection_Homo sapiens_hsa051690.22868932
97Fructose and mannose metabolism_Homo sapiens_hsa000510.21288495
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.20953524
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20143419
100Arachidonic acid metabolism_Homo sapiens_hsa005900.18862712

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