HIST1H3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin assembly (GO:0031497)7.42114774
2regulation of histone H3-K9 methylation (GO:0051570)6.88866201
3* DNA replication-dependent nucleosome assembly (GO:0006335)6.74032927
4* DNA replication-dependent nucleosome organization (GO:0034723)6.74032927
5* nucleosome assembly (GO:0006334)6.41605496
6nuclear pore complex assembly (GO:0051292)5.75328555
7DNA unwinding involved in DNA replication (GO:0006268)5.72404041
8nuclear pore organization (GO:0006999)5.63162955
9* nucleosome organization (GO:0034728)5.57087884
10mitotic chromosome condensation (GO:0007076)5.48097826
11protein localization to kinetochore (GO:0034501)5.43386847
12* protein-DNA complex assembly (GO:0065004)5.42037857
13antibacterial humoral response (GO:0019731)5.36696706
14* chromatin assembly or disassembly (GO:0006333)5.17355790
15innate immune response in mucosa (GO:0002227)5.03820540
16antimicrobial humoral response (GO:0019730)5.02570235
17* protein-DNA complex subunit organization (GO:0071824)4.87043327
18folic acid-containing compound biosynthetic process (GO:0009396)4.82285171
19sister chromatid segregation (GO:0000819)4.71967634
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.69909350
21protein localization to chromosome, centromeric region (GO:0071459)4.67775451
22chromatin remodeling at centromere (GO:0031055)4.56643179
23DNA replication initiation (GO:0006270)4.55689326
24CENP-A containing nucleosome assembly (GO:0034080)4.51333531
25pore complex assembly (GO:0046931)4.31211209
26mitotic sister chromatid segregation (GO:0000070)4.30339259
27regulation of posttranscriptional gene silencing (GO:0060147)4.27326396
28regulation of gene silencing by miRNA (GO:0060964)4.27326396
29regulation of gene silencing by RNA (GO:0060966)4.27326396
30negative regulation of histone methylation (GO:0031061)4.19258122
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.15335625
32protein K6-linked ubiquitination (GO:0085020)4.13148102
33negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.12387224
34DNA strand elongation involved in DNA replication (GO:0006271)4.11434550
35mitotic nuclear envelope disassembly (GO:0007077)4.10827033
36viral mRNA export from host cell nucleus (GO:0046784)4.09265661
37DNA replication-independent nucleosome organization (GO:0034724)4.06700137
38DNA replication-independent nucleosome assembly (GO:0006336)4.06700137
39IMP biosynthetic process (GO:0006188)4.02784137
40DNA duplex unwinding (GO:0032508)4.02426510
41DNA geometric change (GO:0032392)4.02426159
42DNA strand elongation (GO:0022616)3.90085203
43nuclear envelope disassembly (GO:0051081)3.89747754
44membrane disassembly (GO:0030397)3.89747754
45regulation of translational fidelity (GO:0006450)3.88427184
46regulation of megakaryocyte differentiation (GO:0045652)3.87758156
47defense response to Gram-positive bacterium (GO:0050830)3.87212450
48mucosal immune response (GO:0002385)3.83258820
49positive regulation of chromosome segregation (GO:0051984)3.82349142
50telomere maintenance via semi-conservative replication (GO:0032201)3.81294056
51dosage compensation (GO:0007549)3.80355093
52histone exchange (GO:0043486)3.74375218
53chromosome condensation (GO:0030261)3.73866331
54regulation of centriole replication (GO:0046599)3.73108904
55mitotic recombination (GO:0006312)3.70130478
56kinetochore organization (GO:0051383)3.65206510
57translesion synthesis (GO:0019985)3.63057893
58organ or tissue specific immune response (GO:0002251)3.61241996
59positive regulation of mitotic sister chromatid separation (GO:1901970)3.59783904
60positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.59783904
61positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.59783904
62regulation of centrosome cycle (GO:0046605)3.55343889
63IMP metabolic process (GO:0046040)3.52246097
64meiotic chromosome segregation (GO:0045132)3.50484263
65mitotic sister chromatid cohesion (GO:0007064)3.49397211
66regulation of sister chromatid cohesion (GO:0007063)3.46211007
67pre-miRNA processing (GO:0031054)3.45800193
68telomere maintenance via recombination (GO:0000722)3.43142951
69DNA conformation change (GO:0071103)3.37363025
70attachment of spindle microtubules to kinetochore (GO:0008608)3.34804379
71viral transcription (GO:0019083)3.33845004
72positive regulation of histone methylation (GO:0031062)3.31741842
73protoporphyrinogen IX metabolic process (GO:0046501)3.30883605
74microtubule depolymerization (GO:0007019)3.30881606
75translational termination (GO:0006415)3.28805913
76postreplication repair (GO:0006301)3.28204769
77telomere maintenance via telomere lengthening (GO:0010833)3.25503958
78peptidyl-lysine dimethylation (GO:0018027)3.25368401
79regulation of centrosome duplication (GO:0010824)3.24452435
80regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23871757
81nucleotide-excision repair, DNA gap filling (GO:0006297)3.23643149
82mitotic metaphase plate congression (GO:0007080)3.23622277
83DNA packaging (GO:0006323)3.23050290
84ribosomal small subunit assembly (GO:0000028)3.23040183
85rRNA transcription (GO:0009303)3.22325564
86telomere maintenance (GO:0000723)3.22307334
87histone lysine demethylation (GO:0070076)3.22113244
88regulation of spindle organization (GO:0090224)3.21629262
89ATP-dependent chromatin remodeling (GO:0043044)3.20279385
90telomere organization (GO:0032200)3.19071098
91regulation of chromosome segregation (GO:0051983)3.18981528
92DNA topological change (GO:0006265)3.18906096
93DNA synthesis involved in DNA repair (GO:0000731)3.17923663
94protein localization to chromosome (GO:0034502)3.16855181
95metaphase plate congression (GO:0051310)3.15907192
96negative regulation of chromosome segregation (GO:0051985)3.13176728
97regulation of helicase activity (GO:0051095)3.11521394
98histone demethylation (GO:0016577)3.11505895
99regulation of DNA endoreduplication (GO:0032875)3.11411011
100replicative senescence (GO:0090399)3.10832833
101protein complex localization (GO:0031503)3.07788272
102DNA replication checkpoint (GO:0000076)3.07567762
103nucleobase biosynthetic process (GO:0046112)3.07325344
104regulation of translational termination (GO:0006449)3.07245701
105regulation of mammary gland epithelial cell proliferation (GO:0033599)3.05324581
106regulation of spindle checkpoint (GO:0090231)3.04523368
107chromosome segregation (GO:0007059)3.03693480
108mitochondrial DNA metabolic process (GO:0032042)3.02762617
109regulation of RNA export from nucleus (GO:0046831)3.02409633
110regulation of mitotic spindle organization (GO:0060236)2.98889009
111spindle checkpoint (GO:0031577)2.98012864
112protoporphyrinogen IX biosynthetic process (GO:0006782)2.96756089
113regulation of sister chromatid segregation (GO:0033045)2.95128828
114regulation of mitotic sister chromatid separation (GO:0010965)2.95128828
115regulation of mitotic sister chromatid segregation (GO:0033047)2.95128828
116negative regulation of DNA repair (GO:0045738)2.91871340
117regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.91704533
118regulation of mitotic metaphase/anaphase transition (GO:0030071)2.91704533
119non-recombinational repair (GO:0000726)2.90029470
120double-strand break repair via nonhomologous end joining (GO:0006303)2.90029470
121mitotic spindle assembly checkpoint (GO:0007094)2.88330348
122nucleobase-containing small molecule interconversion (GO:0015949)2.88043923
123negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.87959488
124negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.87959488
125negative regulation of mitotic sister chromatid segregation (GO:0033048)2.87959488
126negative regulation of mitotic sister chromatid separation (GO:2000816)2.87959488
127negative regulation of sister chromatid segregation (GO:0033046)2.87959488
128mitotic spindle checkpoint (GO:0071174)2.87826663
129maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.86484875
130peptidyl-arginine omega-N-methylation (GO:0035247)2.86220800
131spindle assembly checkpoint (GO:0071173)2.83910252
132somatic hypermutation of immunoglobulin genes (GO:0016446)2.80032896
133somatic diversification of immune receptors via somatic mutation (GO:0002566)2.80032896
134replication fork processing (GO:0031297)2.79614318

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.41148115
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.83900333
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.36700175
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.23286573
5* SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.13784949
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.99158515
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63723024
8* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.35988223
9* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30069803
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.27377948
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.27334072
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.20829704
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11828234
14* FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse13.8042225
15MYC_19030024_ChIP-ChIP_MESCs_Mouse1.89232717
16* SOX2_16153702_ChIP-ChIP_HESCs_Human1.88557770
17* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.84697495
18* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.81770276
19MYC_19079543_ChIP-ChIP_MESCs_Mouse1.78686928
20EGR1_19374776_ChIP-ChIP_THP-1_Human1.78001499
21SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.68079493
22* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67310632
23IRF1_19129219_ChIP-ChIP_H3396_Human1.66925632
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.59792899
25AR_21909140_ChIP-Seq_LNCAP_Human1.52767914
26* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47597920
27* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.47047081
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.47036274
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46871509
30* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.46364069
31* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43293606
32HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.40299003
33POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38775728
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37327990
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37179479
36* VDR_23849224_ChIP-Seq_CD4+_Human1.35130039
37* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32285755
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31645815
39* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30912000
40* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30385661
41* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28850611
42MYC_22102868_ChIP-Seq_BL_Human1.26632538
43* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25508258
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25008703
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23255724
46DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21746020
47* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18782077
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17881407
49* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.16521869
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.16004311
51* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.15294402
52ELK1_19687146_ChIP-ChIP_HELA_Human1.14826516
53XRN2_22483619_ChIP-Seq_HELA_Human1.13241875
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12980667
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12092268
56* NANOG_16153702_ChIP-ChIP_HESCs_Human1.06136175
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05156521
58ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02266613
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.01730124
60FOXP3_21729870_ChIP-Seq_TREG_Human1.00747801
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00418452
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99126080
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98538782
64PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98430816
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.97022873
66* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96218213
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94964684
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94927818
69THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94327034
70CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92572937
71PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92283906
72BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91215083
73VDR_21846776_ChIP-Seq_THP-1_Human0.91039207
74KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.90012476
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89426012
76ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88433756
77* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.85444818
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84772765
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82947889
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.81660191
81CIITA_25753668_ChIP-Seq_RAJI_Human0.80901630
82EST1_17652178_ChIP-ChIP_JURKAT_Human0.80267900
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.79442474
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.78550792
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.78296798
86TTF2_22483619_ChIP-Seq_HELA_Human0.77984117
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.77937979
88GATA1_22025678_ChIP-Seq_K562_Human0.77900045
89NANOG_21062744_ChIP-ChIP_HESCs_Human0.77267568
90NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.76870684
91ETS1_20019798_ChIP-Seq_JURKAT_Human0.76506589
92ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.75501066
93SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.73975689
94* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.73729814
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.73134439
96KDM5A_27292631_Chip-Seq_BREAST_Human0.72798798
97RBPJ_22232070_ChIP-Seq_NCS_Mouse0.72420107
98PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.70955330
99GABP_17652178_ChIP-ChIP_JURKAT_Human0.70285173
100MAF_26560356_Chip-Seq_TH1_Human0.69372990
101KLF4_18555785_ChIP-Seq_MESCs_Mouse0.69350598
102* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.69210856
103DCP1A_22483619_ChIP-Seq_HELA_Human0.69132315
104GATA2_22383799_ChIP-Seq_G1ME_Mouse0.66420559
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.66197439
106ZNF263_19887448_ChIP-Seq_K562_Human0.65603817
107* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.64575328
108PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.64501136
109POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.64442117
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.64089106
111SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.63354481
112ELF1_17652178_ChIP-ChIP_JURKAT_Human0.63067574
113* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.62751829
114MYC_18940864_ChIP-ChIP_HL60_Human0.62621745
115TCF3_18692474_ChIP-Seq_MEFs_Mouse0.62600787
116GABP_19822575_ChIP-Seq_HepG2_Human0.61929785
117CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.59467969
118YY1_21170310_ChIP-Seq_MESCs_Mouse0.56696107
119SALL4_22934838_ChIP-ChIP_CD34+_Human0.56505097

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.16319412
2MP0003111_abnormal_nucleus_morphology4.56072042
3MP0010307_abnormal_tumor_latency3.91552025
4MP0003077_abnormal_cell_cycle3.84640068
5MP0003693_abnormal_embryo_hatching3.69755925
6MP0004957_abnormal_blastocyst_morpholog3.40530974
7MP0008057_abnormal_DNA_replication3.34578230
8MP0010352_gastrointestinal_tract_polyps3.13382776
9MP0003705_abnormal_hypodermis_morpholog2.62166056
10MP0005076_abnormal_cell_differentiation2.60942838
11MP0008058_abnormal_DNA_repair2.58740293
12MP0000350_abnormal_cell_proliferation2.46527231
13MP0001661_extended_life_span2.30660222
14MP0001730_embryonic_growth_arrest2.27212010
15MP0010234_abnormal_vibrissa_follicle2.26444084
16MP0003123_paternal_imprinting2.21793707
17MP0008007_abnormal_cellular_replicative2.20749624
18MP0008932_abnormal_embryonic_tissue2.18594902
19MP0003656_abnormal_erythrocyte_physiolo2.14139599
20MP0003763_abnormal_thymus_physiology1.97718373
21MP0003718_maternal_effect1.95577790
22MP0008877_abnormal_DNA_methylation1.93654528
23MP0004197_abnormal_fetal_growth/weight/1.92231393
24MP0003121_genomic_imprinting1.86109357
25MP0009697_abnormal_copulation1.84498993
26MP0004808_abnormal_hematopoietic_stem1.83361683
27MP0004147_increased_porphyrin_level1.79853544
28MP0002086_abnormal_extraembryonic_tissu1.78670057
29MP0001697_abnormal_embryo_size1.76848363
30MP0001672_abnormal_embryogenesis/_devel1.75403623
31MP0005380_embryogenesis_phenotype1.75403623
32MP0002084_abnormal_developmental_patter1.74822847
33MP0006054_spinal_hemorrhage1.71596170
34MP0002085_abnormal_embryonic_tissue1.71559819
35MP0000490_abnormal_crypts_of1.65087307
36MP0002080_prenatal_lethality1.64097281
37MP0002160_abnormal_reproductive_system1.63370513
38MP0002396_abnormal_hematopoietic_system1.55693467
39MP0003984_embryonic_growth_retardation1.53498604
40MP0003786_premature_aging1.52744428
41MP0002163_abnormal_gland_morphology1.52539794
42MP0002019_abnormal_tumor_incidence1.51622862
43MP0002088_abnormal_embryonic_growth/wei1.51316755
44MP0000013_abnormal_adipose_tissue1.45827853
45MP0006035_abnormal_mitochondrial_morpho1.43277671
46MP0000703_abnormal_thymus_morphology1.37541346
47MP0000313_abnormal_cell_death1.35793090
48MP0003315_abnormal_perineum_morphology1.35387344
49MP0002009_preneoplasia1.29918023
50MP0002877_abnormal_melanocyte_morpholog1.29463745
51MP0000537_abnormal_urethra_morphology1.20161729
52MP0005645_abnormal_hypothalamus_physiol1.19549213
53MP0002722_abnormal_immune_system1.16004056
54MP0000733_abnormal_muscle_development1.15878973
55MP0001293_anophthalmia1.14846316
56MP0002398_abnormal_bone_marrow1.14271603
57MP0001915_intracranial_hemorrhage1.13619804
58MP0003890_abnormal_embryonic-extraembry1.10823538
59MP0003806_abnormal_nucleotide_metabolis1.10575528
60MP0002638_abnormal_pupillary_reflex1.10565772
61MP0003937_abnormal_limbs/digits/tail_de1.10192680
62MP0001346_abnormal_lacrimal_gland1.08806212
63MP0002111_abnormal_tail_morphology1.07479973
64MP0003787_abnormal_imprinting1.06465342
65MP0003566_abnormal_cell_adhesion1.05150768
66MP0002697_abnormal_eye_size1.04052482
67MP0005410_abnormal_fertilization1.02601139
68MP0000689_abnormal_spleen_morphology1.02584825
69MP0000015_abnormal_ear_pigmentation1.02103777
70MP0008770_decreased_survivor_rate1.01812566
71MP0002166_altered_tumor_susceptibility1.01778248
72MP0001849_ear_inflammation1.01487762
73MP0005220_abnormal_exocrine_pancreas1.00912787
74MP0002092_abnormal_eye_morphology0.99177016
75MP0003567_abnormal_fetal_cardiomyocyte0.96284426
76MP0000003_abnormal_adipose_tissue0.95802866
77MP0005451_abnormal_body_composition0.95651298
78MP0001545_abnormal_hematopoietic_system0.94069857
79MP0005397_hematopoietic_system_phenotyp0.94069857
80MP0005621_abnormal_cell_physiology0.93272180
81MP0000685_abnormal_immune_system0.92587887
82MP0010030_abnormal_orbit_morphology0.91227943
83MP0006072_abnormal_retinal_apoptosis0.89506835
84MP0005384_cellular_phenotype0.89401296
85MP0009703_decreased_birth_body0.88836310
86MP0002006_tumorigenesis0.88731305
87MP0003699_abnormal_female_reproductive0.87680156
88MP0001119_abnormal_female_reproductive0.87597771
89MP0009278_abnormal_bone_marrow0.87231593
90MP0005389_reproductive_system_phenotype0.85160749
91MP0002210_abnormal_sex_determination0.84702737
92MP0005023_abnormal_wound_healing0.82731912
93MP0005187_abnormal_penis_morphology0.81034954
94MP0004381_abnormal_hair_follicle0.80573148
95MP0009053_abnormal_anal_canal0.80468306
96MP0005501_abnormal_skin_physiology0.79629402
97MP0002429_abnormal_blood_cell0.79596388
98MP0001145_abnormal_male_reproductive0.79349042
99MP0005083_abnormal_biliary_tract0.78772024
100MP0002925_abnormal_cardiovascular_devel0.78317778
101MP0003300_gastrointestinal_ulcer0.77340179
102MP0004233_abnormal_muscle_weight0.77317590
103MP0000538_abnormal_urinary_bladder0.77286444
104MP0009672_abnormal_birth_weight0.77059558
105MP0003941_abnormal_skin_development0.76704372
106MP0001929_abnormal_gametogenesis0.75267343
107MP0005671_abnormal_response_to0.75251089
108MP0005623_abnormal_meninges_morphology0.74704659
109MP0002075_abnormal_coat/hair_pigmentati0.74535522
110MP0000371_diluted_coat_color0.73271860
111MP0003861_abnormal_nervous_system0.72429109
112MP0002095_abnormal_skin_pigmentation0.71215590
113MP0008438_abnormal_cutaneous_collagen0.70612960
114MP0010678_abnormal_skin_adnexa0.70578673
115MP0002161_abnormal_fertility/fecundity0.70545299
116MP0003448_altered_tumor_morphology0.70539711
117MP0003119_abnormal_digestive_system0.69600177
118MP0004185_abnormal_adipocyte_glucose0.67607221
119MP0000358_abnormal_cell_content/0.67186970
120MP0003091_abnormal_cell_migration0.66501122
121MP0001216_abnormal_epidermal_layer0.66422493
122MP0001286_abnormal_eye_development0.66242355
123MP0003453_abnormal_keratinocyte_physiol0.65345966
124MP0001835_abnormal_antigen_presentation0.64226799
125MP0000477_abnormal_intestine_morphology0.64131254
126MP0000653_abnormal_sex_gland0.63808926
127MP0000432_abnormal_head_morphology0.63228761
128MP0001800_abnormal_humoral_immune0.63036576
129MP0003698_abnormal_male_reproductive0.62848959
130MP0008260_abnormal_autophagy0.61304441
131MP0000428_abnormal_craniofacial_morphol0.61130301
132MP0005647_abnormal_sex_gland0.60886612
133MP0000762_abnormal_tongue_morphology0.60634919
134MP0005391_vision/eye_phenotype0.59669794
135MP0001919_abnormal_reproductive_system0.58363999

Predicted human phenotypes

RankGene SetZ-score
1IgA deficiency (HP:0002720)4.62164780
2IgM deficiency (HP:0002850)4.53324159
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.01489645
4Chromsome breakage (HP:0040012)3.99898996
5Poikilocytosis (HP:0004447)3.94370547
6Reticulocytopenia (HP:0001896)3.89880156
7Colitis (HP:0002583)3.84416358
8Ependymoma (HP:0002888)3.68867078
9Hypochromic microcytic anemia (HP:0004840)3.54504842
10Abnormality of chromosome stability (HP:0003220)3.42484663
11Impulsivity (HP:0100710)3.29603692
12Oral leukoplakia (HP:0002745)3.22473301
13Medulloblastoma (HP:0002885)3.11148800
14Abnormality of the astrocytes (HP:0100707)3.10717615
15Astrocytoma (HP:0009592)3.10717615
16Birth length less than 3rd percentile (HP:0003561)3.02426520
17Cutaneous melanoma (HP:0012056)2.97357709
18Abnormality of the labia minora (HP:0012880)2.90019485
19Clubbing of toes (HP:0100760)2.89080138
20Abnormality of reticulocytes (HP:0004312)2.84890472
21Agnosia (HP:0010524)2.83108460
22Rhabdomyosarcoma (HP:0002859)2.78112491
23Basal cell carcinoma (HP:0002671)2.77713656
24Abnormality of the heme biosynthetic pathway (HP:0010472)2.76818403
25Colon cancer (HP:0003003)2.75595330
26Short 4th metacarpal (HP:0010044)2.74996703
27Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.74996703
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.71766311
29Selective tooth agenesis (HP:0001592)2.69197665
30Cafe-au-lait spot (HP:0000957)2.67174456
31Microvesicular hepatic steatosis (HP:0001414)2.66966696
32Acanthocytosis (HP:0001927)2.64822231
33Neoplasm of the oral cavity (HP:0100649)2.62703963
34Cortical dysplasia (HP:0002539)2.60956575
35Breast hypoplasia (HP:0003187)2.59293327
36Abnormality of cells of the erythroid lineage (HP:0012130)2.59069381
37Hypoplasia of the pons (HP:0012110)2.55735461
38Glioma (HP:0009733)2.54118386
39Meckel diverticulum (HP:0002245)2.53841777
40High pitched voice (HP:0001620)2.53795530
41Volvulus (HP:0002580)2.50275116
42Abnormality of the ileum (HP:0001549)2.44938795
43Prominent nose (HP:0000448)2.42900415
44Reduced antithrombin III activity (HP:0001976)2.40910490
45Small intestinal stenosis (HP:0012848)2.38604054
46Duodenal stenosis (HP:0100867)2.38604054
47Abnormality of the fingertips (HP:0001211)2.36997047
48Abnormality of the pons (HP:0007361)2.36918763
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.35833957
50Nephroblastoma (Wilms tumor) (HP:0002667)2.34599477
51Sandal gap (HP:0001852)2.34081941
52Abnormality of the preputium (HP:0100587)2.33425285
53Absent thumb (HP:0009777)2.31784047
54Increased nuchal translucency (HP:0010880)2.28683626
55Hypopigmentation of the fundus (HP:0007894)2.28132355
56Biliary tract neoplasm (HP:0100574)2.26887658
57Reticulocytosis (HP:0001923)2.25833776
58Progressive external ophthalmoplegia (HP:0000590)2.24593819
59Myelodysplasia (HP:0002863)2.24560850
60Neoplasm of striated muscle (HP:0009728)2.24133119
61Lipid accumulation in hepatocytes (HP:0006561)2.22990809
62Progressive muscle weakness (HP:0003323)2.21676718
63Patellar aplasia (HP:0006443)2.20639567
64Abnormality of the carotid arteries (HP:0005344)2.20068216
65Embryonal renal neoplasm (HP:0011794)2.19797580
66Ectopic kidney (HP:0000086)2.19579429
67Sloping forehead (HP:0000340)2.19540885
68Abnormal number of erythroid precursors (HP:0012131)2.18957344
69Cerebellar dysplasia (HP:0007033)2.17401196
70Hypergonadotropic hypogonadism (HP:0000815)2.16848165
71Inflammation of the large intestine (HP:0002037)2.16425805
72Macrocytic anemia (HP:0001972)2.16261010
73Duplicated collecting system (HP:0000081)2.14456240
74Bone marrow hypocellularity (HP:0005528)2.13867103
75Absent radius (HP:0003974)2.13574564
76Pallor (HP:0000980)2.12668591
77Ureteral duplication (HP:0000073)2.12257176
78Deviation of the thumb (HP:0009603)2.11775131
7911 pairs of ribs (HP:0000878)2.11520084
80Freckling (HP:0001480)2.11361395
81Heterotopia (HP:0002282)2.11351059
82Malignant gastrointestinal tract tumors (HP:0006749)2.11084003
83Gastrointestinal carcinoma (HP:0002672)2.11084003
84Insomnia (HP:0100785)2.10872027
85Abnormality of the parietal bone (HP:0002696)2.10821050
86Premature graying of hair (HP:0002216)2.09784854
87Squamous cell carcinoma (HP:0002860)2.09751182
88Missing ribs (HP:0000921)2.09661994
89Proximal placement of thumb (HP:0009623)2.08640253
90Dry hair (HP:0011359)2.07975040
91Abnormality of the duodenum (HP:0002246)2.05438570
92Asymmetry of the thorax (HP:0001555)2.04511987
93Erythema (HP:0010783)2.02999199
94Duplication of thumb phalanx (HP:0009942)2.00035216
95Arteriovenous malformation (HP:0100026)2.00032403
96Aplasia/Hypoplasia of the patella (HP:0006498)1.98105060
97Absent forearm bone (HP:0003953)1.97428864
98Aplasia involving forearm bones (HP:0009822)1.97428864
99Rough bone trabeculation (HP:0100670)1.96452157
100Ulnar bowing (HP:0003031)1.96397025
101Gastrointestinal inflammation (HP:0004386)1.95439340
102Neoplasm of the pancreas (HP:0002894)1.95019647
103Amaurosis fugax (HP:0100576)1.93603942
104Gastrointestinal stroma tumor (HP:0100723)1.93312104
105B lymphocytopenia (HP:0010976)1.92573060
106Cellulitis (HP:0100658)1.91954683
107Thyroiditis (HP:0100646)1.91031910
108Renovascular hypertension (HP:0100817)1.90821733
109Abnormal number of incisors (HP:0011064)1.87296999
110Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87127495
111Spastic diplegia (HP:0001264)1.85505680
112External ear malformation (HP:0008572)1.84013092
113Ankle contracture (HP:0006466)1.83979614
114High anterior hairline (HP:0009890)1.82910652
115Dyschromatopsia (HP:0007641)1.81929340
116Short thumb (HP:0009778)1.81816477
117Tracheoesophageal fistula (HP:0002575)1.81497335
118Capillary hemangiomas (HP:0005306)1.81134975
119Hypochromic anemia (HP:0001931)1.79046646
120Abnormality of the 4th metacarpal (HP:0010012)1.78966853
121Increased hepatocellular lipid droplets (HP:0006565)1.78955606
122Sensory axonal neuropathy (HP:0003390)1.78577975
123Abnormality of cochlea (HP:0000375)1.78443567
124Abnormality of the renal collecting system (HP:0004742)1.78311710
125Poikiloderma (HP:0001029)1.76317628
126Orthostatic hypotension (HP:0001278)1.76247618
127Skull defect (HP:0001362)1.76164183
128Rectal prolapse (HP:0002035)1.76133923
129Abnormality of cells of the lymphoid lineage (HP:0012140)1.75454595
130Atresia of the external auditory canal (HP:0000413)1.75188371
131Abnormality of nail color (HP:0100643)1.75119872
132Ridged nail (HP:0001807)1.74585582
133Prostate neoplasm (HP:0100787)1.74527184
134Aplasia cutis congenita (HP:0001057)1.73982893
135Subacute progressive viral hepatitis (HP:0006572)1.73934289
136Abnormality of abdominal situs (HP:0011620)1.73381513
137Abdominal situs inversus (HP:0003363)1.73381513
138Ovarian neoplasm (HP:0100615)1.73117381
139Lymphopenia (HP:0001888)1.73041923
140Lymphoma (HP:0002665)1.73000358
141Down-sloping shoulders (HP:0200021)1.72879526
142Verrucae (HP:0200043)1.72654620
143Papilloma (HP:0012740)1.72654620
144Truncal obesity (HP:0001956)1.72455339
145Autoimmune hemolytic anemia (HP:0001890)1.72445705
146Cellular immunodeficiency (HP:0005374)1.72300175
147Abnormality of pyrimidine metabolism (HP:0004353)1.72266957
148Aplasia/Hypoplasia of the sternum (HP:0006714)1.72075519
149Long eyelashes (HP:0000527)1.71709066
150Acute lymphatic leukemia (HP:0006721)1.71540231
151Abnormality of chromosome segregation (HP:0002916)1.71148510
152Pancytopenia (HP:0001876)1.70933730
153Abnormality of DNA repair (HP:0003254)1.70809881
154Bowel diverticulosis (HP:0005222)1.70219353
155Aplasia/Hypoplasia of the earlobes (HP:0009906)1.70195300
156Hepatitis (HP:0012115)1.67192521
157Abnormality of B cell number (HP:0010975)1.65387571
158Abnormal trabecular bone morphology (HP:0100671)1.65316512

Predicted kinase interactions (KEA)

RankGene SetZ-score
1* VRK15.12079057
2CDC74.58385307
3STK44.37759760
4CDK123.56075869
5EEF2K3.05878592
6NEK22.95486115
7MAP3K102.92720378
8CDK92.91105032
9SCYL22.81039976
10WEE12.73898510
11* RPS6KA52.62435611
12BUB12.39867533
13MAP3K82.37460580
14PKN22.37222495
15RPS6KB22.24619314
16SRPK12.23034699
17EPHA22.21739022
18CHEK22.16693199
19PBK2.08772689
20* AURKB2.02780506
21SMG11.95861340
22TTK1.80939058
23DYRK31.73483567
24NEK11.72080522
25DAPK31.69661976
26ATR1.63735361
27CCNB11.56779757
28PLK11.56488960
29EIF2AK11.55664075
30STK161.55137447
31FLT31.50363631
32CDK81.46356601
33BRD41.44358392
34GRK61.43947027
35CDK41.42616938
36PASK1.39150603
37STK101.29432847
38MAP2K71.26295890
39CHEK11.24067700
40TAF11.23170646
41KDR1.22061538
42CDK71.14830859
43BLK1.12144867
44MST41.10839278
45ACVR1B1.10252687
46MELK1.09933523
47TTN1.09546947
48PLK31.06663053
49ATM1.06266258
50CDK61.03543278
51* PIM11.03461140
52CAMK1D1.02375751
53CDK20.99460005
54BRAF0.98842204
55NME20.96344777
56PIM20.96102959
57CSNK1G10.90097383
58DYRK1B0.89603150
59CSNK1G30.88540142
60STK30.86056769
61CSNK1A1L0.83403623
62IRAK30.81184940
63BRSK20.81053975
64BTK0.79023461
65ALK0.78353686
66CDK10.77140092
67* ZAK0.76027093
68LRRK20.74449841
69PRKAA10.73909513
70MAP3K40.73640566
71CSNK1D0.70943478
72MTOR0.70784077
73TGFBR10.65925041
74* AURKA0.65845027
75EIF2AK30.64803292
76BRSK10.61543394
77PAK40.61067773
78FGFR20.60573113
79TSSK60.59617733
80MST1R0.59034946
81CAMK40.58904697
82TESK20.56809084
83FRK0.55879978
84KSR10.52986015
85PRKDC0.52850477
86MAPKAPK30.52371248
87ILK0.52074304
88MET0.50292848
89RPS6KA40.49979153
90TRIB30.49042758
91PAK20.48829547
92BMX0.48554247
93PDGFRA0.48436360
94MAPKAPK50.47857132
95EIF2AK20.46984906
96PRPF4B0.46536305
97PDK20.46080909
98RPS6KB10.45313950
99LATS10.42252639
100AKT10.41023386
101BCKDK0.40322724
102CLK10.39337860
103CSNK2A20.38597580
104RIPK10.37218018
105ICK0.35032475
106ARAF0.34877601
107* MAPK140.34871852
108PTK60.33674433
109CSNK1G20.33669605
110PLK40.33268186
111TRPM70.33074906
112SYK0.33033865
113CSF1R0.31596063
114NEK90.31043676
115MKNK10.30569812
116PRKCI0.30211308
117BMPR1B0.29757173
118NEK60.29116008
119MARK30.28972982
120MAP2K40.28708815
121FGR0.28536362
122RPS6KC10.27429407
123RPS6KL10.27429407
124RPS6KA10.25723891
125MAP4K10.25719416
126CAMKK20.25365962
127GSK3B0.24792404
128NLK0.24417565
129MAPK110.24396308
130MAP2K30.23972937
131RAF10.23735099
132MKNK20.23465674
133IRAK20.22452181
134MAP3K90.22214078
135CHUK0.21580194
136SGK10.20451413
137RET0.20047473
138* MAPK10.19623425
139FGFR10.19566540
140IRAK40.19085989
141MAPK90.16580729

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.10022662
2Viral carcinogenesis_Homo sapiens_hsa052033.32372178
3DNA replication_Homo sapiens_hsa030303.23327704
4Mismatch repair_Homo sapiens_hsa034302.86197929
5One carbon pool by folate_Homo sapiens_hsa006702.34659567
6Cell cycle_Homo sapiens_hsa041102.12119588
7* Systemic lupus erythematosus_Homo sapiens_hsa0532210.7770020
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91523055
9RNA transport_Homo sapiens_hsa030131.79361154
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.79094211
11Nucleotide excision repair_Homo sapiens_hsa034201.77109560
12Non-homologous end-joining_Homo sapiens_hsa034501.74767856
13Fanconi anemia pathway_Homo sapiens_hsa034601.71052137
14Base excision repair_Homo sapiens_hsa034101.68311024
15* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.68131144
16Homologous recombination_Homo sapiens_hsa034401.62493464
17Ribosome_Homo sapiens_hsa030101.56303299
18Spliceosome_Homo sapiens_hsa030401.55885613
19p53 signaling pathway_Homo sapiens_hsa041151.25311158
20mRNA surveillance pathway_Homo sapiens_hsa030151.15414421
21MicroRNAs in cancer_Homo sapiens_hsa052061.01676789
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93795451
23Pyrimidine metabolism_Homo sapiens_hsa002400.90741242
24Selenocompound metabolism_Homo sapiens_hsa004500.86510018
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84692889
26Small cell lung cancer_Homo sapiens_hsa052220.82323074
27RNA polymerase_Homo sapiens_hsa030200.80223820
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77303195
29RNA degradation_Homo sapiens_hsa030180.72784623
30Chronic myeloid leukemia_Homo sapiens_hsa052200.68922712
31HTLV-I infection_Homo sapiens_hsa051660.68773667
32Oocyte meiosis_Homo sapiens_hsa041140.68392035
33Epstein-Barr virus infection_Homo sapiens_hsa051690.63172822
34Herpes simplex infection_Homo sapiens_hsa051680.59954110
35Non-small cell lung cancer_Homo sapiens_hsa052230.55722027
36Apoptosis_Homo sapiens_hsa042100.54934175
37mTOR signaling pathway_Homo sapiens_hsa041500.53205841
38Bladder cancer_Homo sapiens_hsa052190.50808294
39Antigen processing and presentation_Homo sapiens_hsa046120.50472181
40Lysine degradation_Homo sapiens_hsa003100.50202711
41Intestinal immune network for IgA production_Homo sapiens_hsa046720.48884631
42Basal transcription factors_Homo sapiens_hsa030220.48632805
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46003790
44Central carbon metabolism in cancer_Homo sapiens_hsa052300.44962339
45Colorectal cancer_Homo sapiens_hsa052100.44589630
46Vitamin B6 metabolism_Homo sapiens_hsa007500.40743115
47Hepatitis B_Homo sapiens_hsa051610.40478424
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40182148
49Biosynthesis of amino acids_Homo sapiens_hsa012300.38877724
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.35292453
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.34357849
52N-Glycan biosynthesis_Homo sapiens_hsa005100.33471303
53Fructose and mannose metabolism_Homo sapiens_hsa000510.33414678
54Sulfur relay system_Homo sapiens_hsa041220.32897442
55Purine metabolism_Homo sapiens_hsa002300.31358930
56TGF-beta signaling pathway_Homo sapiens_hsa043500.31288275
57Allograft rejection_Homo sapiens_hsa053300.30833894
58Pancreatic cancer_Homo sapiens_hsa052120.30672937
59Prostate cancer_Homo sapiens_hsa052150.30614602
60B cell receptor signaling pathway_Homo sapiens_hsa046620.30470236
61Glioma_Homo sapiens_hsa052140.30090603
62FoxO signaling pathway_Homo sapiens_hsa040680.29882599
63Autoimmune thyroid disease_Homo sapiens_hsa053200.29389493
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28610034
65Asthma_Homo sapiens_hsa053100.27880741
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27546334
67Graft-versus-host disease_Homo sapiens_hsa053320.27029198
68Pentose phosphate pathway_Homo sapiens_hsa000300.26736416
69Notch signaling pathway_Homo sapiens_hsa043300.26660639
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26566687
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26269017
72Hematopoietic cell lineage_Homo sapiens_hsa046400.26224500
73Hippo signaling pathway_Homo sapiens_hsa043900.25982329
74Proteoglycans in cancer_Homo sapiens_hsa052050.25819813
75Basal cell carcinoma_Homo sapiens_hsa052170.25460925
76Measles_Homo sapiens_hsa051620.25359900
77Melanoma_Homo sapiens_hsa052180.25187960
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24743651
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23607314
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23407897
81Pathways in cancer_Homo sapiens_hsa052000.22140564
82Renin-angiotensin system_Homo sapiens_hsa046140.21648726
83Proteasome_Homo sapiens_hsa030500.21303340
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21226119
85Adherens junction_Homo sapiens_hsa045200.20723465
86HIF-1 signaling pathway_Homo sapiens_hsa040660.20669707
87Thyroid cancer_Homo sapiens_hsa052160.20629764
88Arginine biosynthesis_Homo sapiens_hsa002200.20569328
89Galactose metabolism_Homo sapiens_hsa000520.20124556
90Hedgehog signaling pathway_Homo sapiens_hsa043400.20099163
91Endometrial cancer_Homo sapiens_hsa052130.19430491
92Primary immunodeficiency_Homo sapiens_hsa053400.18850631
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.18390795
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17904609
95Carbon metabolism_Homo sapiens_hsa012000.17624089
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.17619754
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16760234
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.16480123
99Viral myocarditis_Homo sapiens_hsa054160.16350768
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.15465694
101Influenza A_Homo sapiens_hsa051640.15201675
102Pyruvate metabolism_Homo sapiens_hsa006200.15184752
103Legionellosis_Homo sapiens_hsa051340.14996539
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14749694
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14308911
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13618641
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13156504
108Focal adhesion_Homo sapiens_hsa045100.12457786
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.12138826
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.11268585
111AMPK signaling pathway_Homo sapiens_hsa041520.11070413
112Tight junction_Homo sapiens_hsa045300.10979833
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.10943409
114Inositol phosphate metabolism_Homo sapiens_hsa005620.09993171
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09310933
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.09216397
117Type I diabetes mellitus_Homo sapiens_hsa049400.08894837
118Folate biosynthesis_Homo sapiens_hsa007900.08251447
119Acute myeloid leukemia_Homo sapiens_hsa052210.08241508
120Huntingtons disease_Homo sapiens_hsa050160.07969020
121Toxoplasmosis_Homo sapiens_hsa051450.07815086
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.06813401
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.06373195
124Malaria_Homo sapiens_hsa051440.05886590
125Platelet activation_Homo sapiens_hsa046110.05541372
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.05366298
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.05245070
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.04425718

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